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Maud Gratuze, Ph.D. - Publications

Affiliations: 
2018-2022 Neurology Washington University, Saint Louis, St. Louis, MO 
 2022- Institute of Neurophysiopathology (INP) CNRS & Aix-Marseille University 
Area:
Alzheimer's disease - Tau pathology - glia - TREM2 - ApoE
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Drieu A, Du S, Kipnis M, Bosch ME, Herz J, Lee C, Jiang H, Manis M, Ulrich JD, Kipnis J, Holtzman DM, Gratuze M. Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration. Life Science Alliance. 6. PMID 37562846 DOI: 10.26508/lsa.202302087  0.785
2023 Parhizkar S, Gent G, Chen Y, Rensing N, Gratuze M, Strout G, Sviben S, Tycksen E, Zhang Q, Gilmore PE, Sprung R, Malone J, Chen W, Remolina Serrano J, Bao X, et al. Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a -dependent manner in mice. Science Translational Medicine. 15: eade6285. PMID 37099634 DOI: 10.1126/scitranslmed.ade6285  0.598
2023 Xiong M, Wang C, Gratuze M, Saadi F, Bao X, Bosch ME, Lee C, Jiang H, Serrano JR, Gonzales ER, Kipnis M, Holtzman DM. Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy. Molecular Neurodegeneration. 18: 17. PMID 36922879 DOI: 10.1186/s13024-023-00610-x  0.783
2022 Gratuze M, Schlachetzki JCM, D'Oliveira Albanus R, Jain N, Novotny B, Brase L, Rodriguez L, Mansel C, Kipnis M, O'Brien S, Pasillas MP, Lee C, Manis M, Colonna M, Harari O, et al. TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4. Neuron. PMID 36368315 DOI: 10.1016/j.neuron.2022.10.022  0.795
2022 Gratuze M, Jiang H, Wang C, Xiong M, Bao X, Holtzman DM. APOE Antibody Inhibits Aβ-Associated Tau Seeding and Spreading in a Mouse Model. Annals of Neurology. PMID 35285073 DOI: 10.1002/ana.26351  0.791
2021 Gratuze M, Chen Y, Parhizkar S, Jain N, Strickland MR, Serrano JR, Colonna M, Ulrich JD, Holtzman DM. Activated microglia mitigate Aβ-associated tau seeding and spreading. The Journal of Experimental Medicine. 218. PMID 34100905 DOI: 10.1084/jem.20210542  0.797
2021 Wang C, Xiong M, Gratuze M, Bao X, Shi Y, Andhey PS, Manis M, Schroeder C, Yin Z, Madore C, Butovsky O, Artyomov M, Ulrich JD, Holtzman DM. Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia. Neuron. PMID 33831349 DOI: 10.1016/j.neuron.2021.03.024  0.712
2021 Gratuze M, Holtzman DM. Targeting pre-synaptic tau accumulation: a new strategy to counteract tau-mediated synaptic loss and memory deficits. Neuron. 109: 741-743. PMID 33662267 DOI: 10.1016/j.neuron.2021.02.014  0.547
2021 Xiong M, Jiang H, Serrano JR, Gonzales ER, Wang C, Gratuze M, Hoyle R, Bien-Ly N, Silverman AP, Sullivan PM, Watts RJ, Ulrich JD, Zipfel GJ, Holtzman DM. APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function. Science Translational Medicine. 13. PMID 33597265 DOI: 10.1126/scitranslmed.abd7522  0.735
2021 Guisle I, Gratuze M, Petry S, Morin F, Keraudren R, Whittington RA, Hébert SS, Mongrain V, Planel E. Circadian and sleep/wake-dependent variations in tau phosphorylation are driven by temperature. Sleep. 43. PMID 31702011 DOI: 10.1093/sleep/zsz266  0.468
2020 Gratuze M, Leyns CE, Sauerbeck AD, St-Pierre MK, Xiong M, Kim N, Remolina Serrano J, Tremblay MÈ, Kummer TT, Colonna M, Ulrich JD, Holtzman DM. Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration. The Journal of Clinical Investigation. PMID 32544086 DOI: 10.1172/Jci138179  0.609
2020 Sauerbeck AD, Gangolli M, Reitz SJ, Salyards MH, Kim SH, Hemingway C, Gratuze M, Makkapati T, Kerschensteiner M, Holtzman DM, Brody DL, Kummer TT. SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain Injury. Neuron. PMID 32392471 DOI: 10.1016/J.Neuron.2020.04.012  0.49
2019 Gratuze M, Joly-Amado A, Buee L, Vieau D, Blum D. Tau, Diabetes and Insulin. Advances in Experimental Medicine and Biology. 1184: 259-287. PMID 32096044 DOI: 10.1007/978-981-32-9358-8_21  0.608
2019 Leyns CEG, Gratuze M, Narasimhan S, Jain N, Koscal LJ, Jiang H, Manis M, Colonna M, Lee VMY, Ulrich JD, Holtzman DM. TREM2 function impedes tau seeding in neuritic plaques. Nature Neuroscience. PMID 31235932 DOI: 10.1038/S41593-019-0433-0  0.74
2019 Gratuze M, Josset N, Petry FR, Pflieger M, Jong LE, Truchetti G, Poitras I, Julien J, Bezeau F, Morin F, Samadi P, Cicchetti F, Bretzner F, Planel E. The toxin MPTP generates similar cognitive and locomotor deficits in hTau and Tau Knock-Out mice. Brain Research. PMID 30641037 DOI: 10.1016/J.Brainres.2019.01.016  0.594
2018 Gratuze M, Leyns CEG, Holtzman DM. New insights into the role of TREM2 in Alzheimer's disease. Molecular Neurodegeneration. 13: 66. PMID 30572908 DOI: 10.1186/S13024-018-0298-9  0.765
2018 Joly-Amado A, Gratuze M, Benderradji H, Vieau D, Buée L, Blum D. [Brain insulin signaling and Tau: impact for Alzheimer's disease and Tauopathies]. Medecine Sciences : M/S. 34: 929-935. PMID 30526837 DOI: 10.1051/Medsci/2018238  0.567
2018 Whittington RA, Virág L, Gratuze M, Lewkowitz-Shpuntoff H, Cheheltanan M, Petry F, Poitras I, Morin F, Planel E. Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain. Neurobiology of Aging. 75: 11-24. PMID 30508732 DOI: 10.1016/j.neurobiolaging.2018.10.027  0.68
2018 Gratuze M, Joly-Amado A, Vieau D, Buée L, Blum D. Mutual relationship between Tau and central insulin signalling: consequences for AD and Tauopathies ? Neuroendocrinology. PMID 29439247 DOI: 10.1159/000487641  0.522
2017 Gratuze M, Julien J, Morin F, Marette A, Planel E. Differential effects of voluntary treadmill exercise and caloric restriction on tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology fed with Western diet. Progress in Neuro-Psychopharmacology & Biological Psychiatry. PMID 28779908 DOI: 10.1016/j.pnpbp.2017.08.001  0.619
2017 Gratuze M, Planel E. Regulation of brain insulin signaling: A new function for tau. The Journal of Experimental Medicine. 214: 2171-2173. PMID 28652305 DOI: 10.1084/jem.20170979  0.444
2017 Gratuze M, Julien J, Petry FR, Morin F, Planel E. Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer's disease-like tau pathology. Scientific Reports. 7: 46359. PMID 28402338 DOI: 10.1038/srep46359  0.619
2017 Gratuze M, El Khoury NB, Turgeon A, Julien C, Marcouiller F, Morin F, Whittington RA, Marette A, Calon F, Planel E. Tau hyperphosphorylation in the brain of ob/ob mice is due to hypothermia: Importance of thermoregulation in linking diabetes and Alzheimer's disease. Neurobiology of Disease. 98: 1-8. PMID 27793638 DOI: 10.1016/j.nbd.2016.10.004  0.656
2016 Gratuze M, Julien J, Morin F, Calon F, Hébert SS, Marette A, Planel E. High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology. Neurobiology of Aging. 47: 71-73. PMID 27565300 DOI: 10.1016/j.neurobiolaging.2016.07.016  0.692
2016 Gratuze M, Cisbani G, Cicchetti F, Planel E. Is Huntington's disease a tauopathy? Brain : a Journal of Neurology. 139: 1014-25. PMID 26969684 DOI: 10.1093/brain/aww021  0.509
2016 El Khoury NB, Gratuze M, Petry F, Papon MA, Julien C, Marcouiller F, Morin F, Nicholls SB, Calon F, Hébert SS, Marette A, Planel E. Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice. Neurobiology of Disease. 88: 55-65. PMID 26777665 DOI: 10.1016/j.nbd.2016.01.005  0.525
2015 Whittington RA, Virág L, Gratuze M, Petry FR, Noël A, Poitras I, Truchetti G, Marcouiller F, Papon MA, El Khoury N, Wong K, Bretteville A, Morin F, Planel E. Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro. Neurobiology of Aging. 36: 2414-28. PMID 26058840 DOI: 10.1016/j.neurobiolaging.2015.05.002  0.442
2015 Gratuze M, Noël A, Julien C, Cisbani G, Milot-Rousseau P, Morin F, Dickler M, Goupil C, Bezeau F, Poitras I, Bissonnette S, Whittington RA, Hébert SS, Cicchetti F, Parker JA, et al. Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease. Human Molecular Genetics. 24: 86-99. PMID 25205109 DOI: 10.1093/hmg/ddu456  0.488
2014 El Khoury NB, Gratuze M, Papon MA, Bretteville A, Planel E. Insulin dysfunction and Tau pathology. Frontiers in Cellular Neuroscience. 8: 22. PMID 24574966 DOI: 10.3389/fncel.2014.00022  0.315
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