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Rafael Franco - Publications

Affiliations: 
Universitat de Barcelona, Barcelona, Cataluña, Spain 
Area:
Membrane Receptors and Intercellular Communication
Website:
https://www.bq.ub.edu/recep/franco.html
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Year Citation  Score
2020 Navarro G, Gonzalez A, Campanacci S, Rivas-Santisteban R, Reyes-Resina I, Casajuana-Martin N, Cordomí A, Pardo L, Franco R. Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A receptor. Computational and Structural Biotechnology Journal. 18: 2723-2732. PMID 33101610 DOI: 10.1016/j.csbj.2020.09.028  0.315
2019 De Filippo E, Hinz S, Pellizzari V, Deganutti G, El-Tayeb A, Navarro G, Franco R, Moro S, Schiedel AC, Müller CE. A and A adenosine receptors: the extracellular loop 2 determines high (A) or low affinity (A) for adenosine. Biochemical Pharmacology. 113718. PMID 31751537 DOI: 10.1016/J.Bcp.2019.113718  0.318
2018 Franco R, Aguinaga D, Jiménez J, Lillo J, Martínez-Pinilla E, Navarro G. Biased receptor functionality versus biased agonism in G-protein-coupled receptors. Biomolecular Concepts. 9: 143-154. PMID 30864350 DOI: 10.1515/bmc-2018-0013  0.313
2018 Navarro G, Medrano M, Aguinaga D, Vega-Quiroga I, Lillo A, Jiménez J, Casanovas M, Canela EI, Mallol J, Gysling K, Franco R. Differential effect of amphetamine over the corticotropin-releasing factor CRF receptor, the orexin OX receptor and the CRF-OX heteroreceptor complex. Neuropharmacology. PMID 30465812 DOI: 10.1016/j.neuropharm.2018.11.014  0.353
2018 Reyes-Resina I, Navarro G, Aguinaga D, Canela EI, Schoeder CT, Zaluski M, Kiec-Kononowicz K, Saura CA, Müller CE, Franco R. Molecular and functional interaction between GPR18 and cannabinoid CB G-protein-coupled receptors. Relevance in neurodegenerative diseases. Biochemical Pharmacology. PMID 29870711 DOI: 10.1016/J.Bcp.2018.06.001  0.344
2018 Hinz S, Navarro G, Borroto-Escuela D, Seibt BF, Ammon YC, de Filippo E, Danish A, Lacher SK, Červinková B, Rafehi M, Fuxe K, Schiedel AC, Franco R, Müller CE. Adenosine Areceptor ligand recognition and signaling is blocked by Areceptors. Oncotarget. 9: 13593-13611. PMID 29568380 DOI: 10.18632/Oncotarget.24423  0.316
2018 Navarro G, Cordomí A, Brugarolas M, Moreno E, Aguinaga D, Pérez-Benito L, Ferre S, Cortés A, Casadó V, Mallol J, Canela EI, Lluís C, Pardo L, McCormick PJ, Franco R. Cross-communication between Gand Gin a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain. Bmc Biology. 16: 24. PMID 29486745 DOI: 10.1186/S12915-018-0491-X  0.307
2018 Reyes-Resina I, Aguinaga D, Labandeira-García JL, Lanciego JL, Navarro G, Franco R. Usefulness of identifying G-protein-coupled receptor dimers for diagnosis and therapy of neurodegenerative diseases and of gliomas. Histology and Histopathology. 11963. PMID 29336473 DOI: 10.14670/HH-11-963  0.316
2016 Rodríguez-Ruiz M, Moreno E, Moreno-Delgado D, Navarro G, Mallol J, Cortés A, Lluís C, Canela EI, Casadó V, McCormick PJ, Franco R. Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer's Disease. Molecular Neurobiology. PMID 27370794 DOI: 10.1007/S12035-016-9995-Y  0.315
2016 Martinez-Pinilla E, Rabal O, Reyes-Resina I, Zamarbide M, Navarro G, Sanchez-Arias JA, de Miguel I, Lanciego JL, Oyarzabal J, Franco R. Two affinity sites of cannabinoid CB2 receptor identified by a novel homogeneous binding assay. The Journal of Pharmacology and Experimental Therapeutics. PMID 27358483 DOI: 10.1124/Jpet.116.234948  0.327
2016 Franco R, Martínez-Pinilla E, Lanciego JL, Navarro G. Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization. Frontiers in Pharmacology. 7: 76. PMID 27065866 DOI: 10.3389/fphar.2016.00076  0.325
2014 George SR, Kern A, Smith RG, Franco R. Dopamine receptor heteromeric complexes and their emerging functions. Progress in Brain Research. 211: 183-200. PMID 24968781 DOI: 10.1016/B978-0-444-63425-2.00008-8  0.303
2014 Pinna A, Bonaventura J, Farré D, Sánchez M, Simola N, Mallol J, Lluís C, Costa G, Baqi Y, Müller CE, Cortés A, McCormick P, Canela EI, Martínez-Pinilla E, Lanciego JL, ... ... Franco R, et al. L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies. Experimental Neurology. 253: 180-91. PMID 24412491 DOI: 10.1016/J.Expneurol.2013.12.021  0.305
2013 Navarro G, McCormick PJ, Mallol J, Lluís C, Franco R, Cortés A, Casadó V, Canela EI, Ferré S. Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology. Methods in Molecular Biology (Clifton, N.J.). 964: 95-105. PMID 23296780 DOI: 10.1007/978-1-62703-251-3_7  0.342
2013 Gracia E, Farré D, Cortés A, Ferrer-Costa C, Orozco M, Mallol J, Lluís C, Canela EI, McCormick PJ, Franco R, Fanelli F, Casadó V. The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1048-61. PMID 23193172 DOI: 10.1096/Fj.12-212621  0.422
2012 Canela L, Selga E, García-Martínez JM, Amaral OB, Fernández-Dueñas V, Alberch J, Canela EI, Franco R, Noé V, Lluís C, Ciudad CJ, Ciruela F. Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synuclein expression. Gene. 508: 199-205. PMID 22892378 DOI: 10.1016/J.Gene.2012.07.074  0.32
2012 Callén L, Moreno E, Barroso-Chinea P, Moreno-Delgado D, Cortés A, Mallol J, Casadó V, Lanciego JL, Franco R, Lluis C, Canela EI, McCormick PJ. Cannabinoid receptors CB1 and CB2 form functional heteromers in brain. The Journal of Biological Chemistry. 287: 20851-65. PMID 22532560 DOI: 10.1074/Jbc.M111.335273  0.356
2011 Aymerich MS, López-Azcárate J, Bonaventura J, Navarro G, Fernández-Suárez D, Casadó V, Mayor F, Lluís C, Valencia M, Artieda J, Franco R. Real-Time G-Protein-Coupled Receptor Imaging to Understand and Quantify Receptor Dynamics The Scientific World Journal. 11: 1995-2010. PMID 22125451 DOI: 10.1100/2011/690858  0.317
2011 Armentero MT, Pinna A, Ferré S, Lanciego JL, Müller CE, Franco R. Past, present and future of A2A adenosine receptor antagonists in the therapy of Parkinson's disease Pharmacology & Therapeutics. 132: 280-299. PMID 21810444 DOI: 10.1016/J.Pharmthera.2011.07.004  0.339
2011 Moreno E, Vaz SH, Cai NS, Ferrada C, Quiroz C, Barodia SK, Kabbani N, Canela EI, McCormick PJ, Lluis C, Franco R, Ribeiro JA, Sebastião AM, Ferré S. Dopamine-galanin receptor heteromers modulate cholinergic neurotransmission in the rat ventral hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7412-23. PMID 21593325 DOI: 10.1523/Jneurosci.0191-11.2011  0.339
2011 Gracia E, Pérez-Capote K, Moreno E, Barkešová J, Mallol J, Lluís C, Franco R, Cortés A, Casadó V, Canela EI. A2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase. The Biochemical Journal. 435: 701-9. PMID 21306300 DOI: 10.1042/BJ20101749  0.334
2011 Moreno E, Hoffmann H, Gonzalez-Sepúlveda M, Navarro G, Casadó V, Cortés A, Mallol J, Vignes M, McCormick PJ, Canela EI, Lluís C, Moratalla R, Ferré S, Ortiz J, Franco R. Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway. The Journal of Biological Chemistry. 286: 5846-54. PMID 21173143 DOI: 10.1074/Jbc.M110.161489  0.321
2011 Ferré S, Lluis C, Lanciego JL, Franco R. Prime time for G-protein-coupled receptor heteromers as therapeutic targets for CNS disorders: the dopamine D₁-D₃ receptor heteromer. Cns & Neurological Disorders Drug Targets. 9: 596-600. PMID 20632968 DOI: 10.2174/187152710793361603  0.336
2010 Ferré S, Lluís C, Justinova Z, Quiroz C, Orru M, Navarro G, Canela EI, Franco R, Goldberg SR. Adenosine-cannabinoid receptor interactions. Implications for striatal function. British Journal of Pharmacology. 160: 443-53. PMID 20590556 DOI: 10.1111/j.1476-5381.2010.00723.x  0.321
2010 Navarro G, Ferré S, Cordomi A, Moreno E, Mallol J, Casadó V, Cortés A, Hoffmann H, Ortiz J, Canela EI, Lluís C, Pardo L, Franco R, Woods AS. Interactions between intracellular domains as key determinants of the quaternary structure and function of receptor heteromers. The Journal of Biological Chemistry. 285: 27346-59. PMID 20562103 DOI: 10.1074/Jbc.M110.115634  0.36
2010 Ferré S, Woods AS, Navarro G, Aymerich M, Lluís C, Franco R. Calcium-mediated modulation of the quaternary structure and function of adenosine A2A-dopamine D2 receptor heteromers. Current Opinion in Pharmacology. 10: 67-72. PMID 19896897 DOI: 10.1016/J.Coph.2009.10.002  0.34
2009 Martínez Muñoz L, Lucas P, Navarro G, Checa AI, Franco R, Martínez-A C, Rodríguez-Frade JM, Mellado M. Dynamic regulation of CXCR1 and CXCR2 homo- and heterodimers. Journal of Immunology (Baltimore, Md. : 1950). 183: 7337-46. PMID 19890050 DOI: 10.4049/jimmunol.0901802  0.331
2009 Canela L, Fernández-Dueñas V, Albergaria C, Watanabe M, Lluís C, Mallol J, Canela EI, Franco R, Luján R, Ciruela F. The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function. Journal of Neurochemistry. 111: 555-67. PMID 19694902 DOI: 10.1111/J.1471-4159.2009.06348.X  0.347
2009 Navarro G, Aymerich MS, Marcellino D, Cortés A, Casadó V, Mallol J, Canela EI, Agnati L, Woods AS, Fuxe K, Lluís C, Lanciego JL, Ferré S, Franco R. Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors. The Journal of Biological Chemistry. 284: 28058-68. PMID 19632986 DOI: 10.1074/Jbc.M109.034231  0.339
2009 Ferrada C, Moreno E, Casadó V, Bongers G, Cortés A, Mallol J, Canela EI, Leurs R, Ferré S, Lluís C, Franco R. Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors. British Journal of Pharmacology. 157: 64-75. PMID 19413572 DOI: 10.1111/J.1476-5381.2009.00152.X  0.333
2009 Cabello N, Gandía J, Bertarelli DC, Watanabe M, Lluís C, Franco R, Ferré S, Luján R, Ciruela F. Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells. Journal of Neurochemistry. 109: 1497-507. PMID 19344374 DOI: 10.1111/J.1471-4159.2009.06078.X  0.346
2009 Ferré S, Goldberg SR, Lluis C, Franco R. Looking for the role of cannabinoid receptor heteromers in striatal function. Neuropharmacology. 56: 226-34. PMID 18691604 DOI: 10.1016/j.neuropharm.2008.06.076  0.318
2008 Navarro G, Carriba P, Gandía J, Ciruela F, Casadó V, Cortés A, Mallol J, Canela EI, Lluis C, Franco R. Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer. Thescientificworldjournal. 8: 1088-97. PMID 18956124 DOI: 10.1100/Tsw.2008.136  0.303
2008 Gracia E, Cortés A, Meana JJ, García-Sevilla J, Herhsfield MS, Canela EI, Mallol J, Lluís C, Franco R, Casadó V. Human adenosine deaminase as an allosteric modulator of human A1 adenosine receptor: abolishment of negative cooperativity for [3H](R)‐pia binding to the caudate nucleus Journal of Neurochemistry. 107: 161-170. PMID 18680557 DOI: 10.1111/J.1471-4159.2008.05602.X  0.331
2008 Gandia J, Galino J, Amaral OB, Soriano A, Lluís C, Franco R, Ciruela F. Detection of higher-order G protein-coupled receptor oligomers by a combined BRET-BiFC technique. Febs Letters. 582: 2979-84. PMID 18675812 DOI: 10.1016/J.Febslet.2008.07.045  0.313
2008 Franco R, Casadó V, Cortés A, Pérez-Capote K, Mallol J, Canela E, Ferré S, Lluis C. Novel pharmacological targets based on receptor heteromers. Brain Research Reviews. 58: 475-82. PMID 18620000 DOI: 10.1016/j.brainresrev.2008.06.002  0.351
2008 Woods AS, Marcellino D, Jackson SN, Franco R, Ferré S, Agnati LF, Fuxe K. How calmodulin interacts with the adenosine A(2A) and the dopamine D(2) receptors. Journal of Proteome Research. 7: 3428-34. PMID 18590318 DOI: 10.1021/Pr8001782  0.353
2008 Ferrada C, Ferré S, Casadó V, Cortés A, Justinova Z, Barnes C, Canela EI, Goldberg SR, Leurs R, Lluis C, Franco R. Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function. Neuropharmacology. 55: 190-7. PMID 18547596 DOI: 10.1016/J.Neuropharm.2008.05.008  0.33
2008 Marcellino D, Carriba P, Filip M, Borgkvist A, Frankowska M, Bellido I, Tanganelli S, Müller CE, Fisone G, Lluis C, Agnati LF, Franco R, Fuxe K. Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis. Neuropharmacology. 54: 815-23. PMID 18262573 DOI: 10.1016/J.Neuropharm.2007.12.011  0.36
2008 Ferre S, Ciruela F, Borycz J, Solinas M, Quarta D, Antoniou K, Quiroz C, Justinova Z, Lluis C, Franco R, Goldberg SR. Adenosine A1-A2A receptor heteromers: new targets for caffeine in the brain. Frontiers in Bioscience : a Journal and Virtual Library. 13: 2391-9. PMID 17981720 DOI: 10.2741/2852  0.333
2007 Ferré S, Ciruela F, Quiroz C, Luján R, Popoli P, Cunha RA, Agnati LF, Fuxe K, Woods AS, Lluis C, Franco R. Adenosine receptor heteromers and their integrative role in striatal function. Thescientificworldjournal. 7: 74-85. PMID 17982579 DOI: 10.1100/Tsw.2007.211  0.369
2007 Franco R, Casadó V, Cortés A, Ferrada C, Mallol J, Woods A, Lluis C, Canela EI, Ferré S. Basic concepts in G-protein-coupled receptor homo- and heterodimerization. Thescientificworldjournal. 7: 48-57. PMID 17982576 DOI: 10.1100/Tsw.2007.197  0.349
2007 Casadó V, Cortés A, Ciruela F, Mallol J, Ferré S, Lluis C, Canela EI, Franco R. Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index. Pharmacology & Therapeutics. 116: 343-54. PMID 17935788 DOI: 10.1016/J.Pharmthera.2007.05.010  0.343
2007 Fredholm BB, Chern Y, Franco R, Sitkovsky M. Aspects of the general biology of adenosine A2A signaling. Progress in Neurobiology. 83: 263-76. PMID 17804147 DOI: 10.1016/J.Pneurobio.2007.07.005  0.35
2007 Ferré S, Ciruela F, Woods AS, Lluis C, Franco R. Functional relevance of neurotransmitter receptor heteromers in the central nervous system. Trends in Neurosciences. 30: 440-6. PMID 17692396 DOI: 10.1016/J.Tins.2007.07.001  0.341
2007 Canela L, Luján R, Lluís C, Burgueño J, Mallol J, Canela EI, Franco R, Ciruela F. The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor. Molecular and Cellular Neurosciences. 36: 1-12. PMID 17689978 DOI: 10.1016/J.Mcn.2007.05.007  0.322
2007 Fuxe K, Ferré S, Genedani S, Franco R, Agnati LF. Adenosine receptor-dopamine receptor interactions in the basal ganglia and their relevance for brain function. Physiology & Behavior. 92: 210-7. PMID 17572452 DOI: 10.1016/j.physbeh.2007.05.034  0.361
2007 Ferré S, Agnati LF, Ciruela F, Lluis C, Woods AS, Fuxe K, Franco R. Neurotransmitter receptor heteromers and their integrative role in 'local modules': the striatal spine module. Brain Research Reviews. 55: 55-67. PMID 17408563 DOI: 10.1016/J.Brainresrev.2007.01.007  0.353
2007 Carriba P, Ortiz O, Patkar K, Justinova Z, Stroik J, Themann A, Müller C, Woods AS, Hope BT, Ciruela F, Casadó V, Canela EI, Lluis C, Goldberg SR, Moratalla R, ... Franco R, et al. Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 2249-59. PMID 17356572 DOI: 10.1038/Sj.Npp.1301375  0.325
2007 Cabello N, Remelli R, Canela L, Soriguera A, Mallol J, Canela EI, Robbins MJ, Lluis C, Franco R, McIlhinney RA, Ciruela F. Actin-binding protein alpha-actinin-1 interacts with the metabotropic glutamate receptor type 5b and modulates the cell surface expression and function of the receptor. The Journal of Biological Chemistry. 282: 12143-53. PMID 17311919 DOI: 10.1074/Jbc.M608880200  0.341
2006 Agnati LF, Ferré S, Genedani S, Leo G, Guidolin D, Filaferro M, Carriba P, Casadó V, Lluis C, Franco R, Woods AS, Fuxe K. Allosteric modulation of dopamine D2 receptors by homocysteine. Journal of Proteome Research. 5: 3077-83. PMID 17081059 DOI: 10.1021/pr0601382  0.345
2006 Franco R, Casadó V, Mallol J, Ferrada C, Ferré S, Fuxe K, Cortés A, Ciruela F, Lluis C, Canela EI. The two-state dimer receptor model: a general model for receptor dimers. Molecular Pharmacology. 69: 1905-12. PMID 16501032 DOI: 10.1124/Mol.105.020685  0.33
2006 Ciruela F, Casadó V, Rodrigues RJ, Luján R, Burgueño J, Canals M, Borycz J, Rebola N, Goldberg SR, Mallol J, Cortés A, Canela EI, López-Giménez JF, Milligan G, Lluis C, ... ... Franco R, et al. Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2080-7. PMID 16481441 DOI: 10.1523/Jneurosci.3574-05.2006  0.339
2005 Saura J, Angulo E, Ejarque A, Casadó V, Tusell JM, Moratalla R, Chen JF, Schwarzschild MA, Lluis C, Franco R, Serratosa J. Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia. Journal of Neurochemistry. 95: 919-29. PMID 16092928 DOI: 10.1111/J.1471-4159.2005.03395.X  0.317
2005 Agnati LF, Ferre S, Burioni R, Woods A, Genedani S, Franco R, Fuxe K. Existence and theoretical aspects of homomeric and heteromeric dopamine receptor complexes and their relevance for neurological diseases. Neuromolecular Medicine. 7: 61-78. PMID 16052039 DOI: 10.1385/Nmm:7:1-2:061  0.334
2005 Ciruela F, Canela L, Burgueño J, Soriguera A, Cabello N, Canela EI, Casadó V, Cortés A, Mallol J, Woods AS, Ferré S, Lluis C, Franco R. Heptaspanning membrane receptors and cytoskeletal/scaffolding proteins: focus on adenosine, dopamine, and metabotropic glutamate receptor function. Journal of Molecular Neuroscience : Mn. 26: 277-92. PMID 16012201 DOI: 10.1385/Jmn:26:2-3:277  0.302
2005 Franco R, Ciruela F, Casadó V, Cortes A, Canela EI, Mallol J, Agnati LF, Ferré S, Fuxe K, Lluis C. Partners for adenosine A1 receptors. Journal of Molecular Neuroscience : Mn. 26: 221-32. PMID 16012195 DOI: 10.1385/Jmn:26:2-3:221  0.354
2005 Woods AS, Ciruela F, Fuxe K, Agnati LF, Lluis C, Franco R, Ferré S. Role of electrostatic interaction in receptor-receptor heteromerization. Journal of Molecular Neuroscience : Mn. 26: 125-32. PMID 16012186 DOI: 10.1385/Jmn:26:2-3:125  0.345
2005 Franco R, Casadó V, Mallol J, Ferré S, Fuxe K, Cortés A, Ciruela F, Lluis C, Canela EI. Dimer-based model for heptaspanning membrane receptors. Trends in Biochemical Sciences. 30: 360-6. PMID 15951182 DOI: 10.1016/J.Tibs.2005.05.010  0.301
2005 Torvinen M, Torri C, Tombesi A, Marcellino D, Watson S, Lluis C, Franco R, Fuxe K, Agnati LF. Trafficking of adenosine A2A and dopamine D2 receptors. Journal of Molecular Neuroscience : Mn. 25: 191-200. PMID 15784967 DOI: 10.1385/JMN:25:2:191  0.303
2005 Torvinen M, Marcellino D, Canals M, Agnati LF, Lluis C, Franco R, Fuxe K. Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes. Molecular Pharmacology. 67: 400-7. PMID 15539641 DOI: 10.1124/mol.104.003376  0.34
2004 Quarta D, Borycz J, Solinas M, Patkar K, Hockemeyer J, Ciruela F, Lluis C, Franco R, Woods AS, Goldberg SR, Ferré S. Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation. Journal of Neurochemistry. 91: 873-80. PMID 15525341 DOI: 10.1111/J.1471-4159.2004.02761.X  0.307
2004 Burgueño J, Canela EI, Mallol J, Lluis C, Franco R, Ciruela F. Mutual regulation between metabotropic glutamate type 1alpha receptor and caveolin proteins: from traffick to constitutive activity. Experimental Cell Research. 300: 23-34. PMID 15383311 DOI: 10.1016/J.Yexcr.2004.06.013  0.335
2004 Agnati LF, Ferré S, Leo G, Lluis C, Canela EI, Franco R, Fuxe K. On the molecular basis of the receptor mosaic hypothesis of the engram. Cellular and Molecular Neurobiology. 24: 501-16. PMID 15233375  0.301
2004 Ferré S, Ciruela F, Canals M, Marcellino D, Burgueno J, Casadó V, Hillion J, Torvinen M, Fanelli F, Benedetti Pd Pd, Goldberg SR, Bouvier M, Fuxe K, Agnati LF, Lluis C, ... Franco R, et al. Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders. Parkinsonism & Related Disorders. 10: 265-71. PMID 15196504 DOI: 10.1016/J.Parkreldis.2004.02.014  0.37
2004 Canals M, Burgueño J, Marcellino D, Cabello N, Canela EI, Mallol J, Agnati L, Ferré S, Bouvier M, Fuxe K, Ciruela F, Lluis C, Franco R. Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. Journal of Neurochemistry. 88: 726-34. PMID 14720222 DOI: 10.1046/J.1471-4159.2003.02200.X  0.327
2003 Canals M, Marcellino D, Fanelli F, Ciruela F, de Benedetti P, Goldberg SR, Neve K, Fuxe K, Agnati LF, Woods AS, Ferré S, Lluis C, Bouvier M, Franco R. Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. The Journal of Biological Chemistry. 278: 46741-9. PMID 12933819 DOI: 10.1074/Jbc.M306451200  0.332
2003 Burgueño J, Enrich C, Canela EI, Mallol J, Lluis C, Franco R, Ciruela F. Metabotropic glutamate type 1α receptor localizes in low-density caveolin-rich plasma membrane fractions Journal of Neurochemistry. 86: 785-791. PMID 12887677 DOI: 10.1046/J.1471-4159.2003.01842.X  0.304
2003 Agnati LF, Ferré S, Lluis C, Franco R, Fuxe K. Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons. Pharmacological Reviews. 55: 509-50. PMID 12869660 DOI: 10.1124/pr.55.3.2  0.366
2003 Burgueño J, Blake DJ, Benson MA, Tinsley CL, Esapa CT, Canela EI, Penela P, Mallol J, Mayor F, Lluis C, Franco R, Ciruela F. The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin. The Journal of Biological Chemistry. 278: 37545-52. PMID 12837758 DOI: 10.1074/Jbc.M302809200  0.326
2003 Franco R, Canals M, Marcellino D, Ferré S, Agnati L, Mallol J, Casadó V, Ciruela F, Fuxe K, Lluis C, Canela EI. Regulation of heptaspanning-membrane-receptor function by dimerization and clustering. Trends in Biochemical Sciences. 28: 238-43. PMID 12765835 DOI: 10.1016/S0968-0004(03)00065-3  0.328
2003 Escriche M, Burgueño J, Ciruela F, Canela EI, Mallol J, Enrich C, Lluís C, Franco R. Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: Morphological evidence of endosomal sorting and receptor recycling Experimental Cell Research. 285: 72-90. PMID 12681288 DOI: 10.1016/S0014-4827(02)00090-3  0.346
2002 Ferré S, Karcz-Kubicha M, Hope BT, Popoli P, Burgueño J, Gutiérrez MA, Casadó V, Fuxe K, Goldberg SR, Lluis C, Franco R, Ciruela F. Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function. Proceedings of the National Academy of Sciences of the United States of America. 99: 11940-5. PMID 12189203 DOI: 10.1073/Pnas.172393799  0.323
2002 Hillion J, Canals M, Torvinen M, Casado V, Scott R, Terasmaa A, Hansson A, Watson S, Olah ME, Mallol J, Canela EI, Zoli M, Agnati LF, Ibanez CF, Lluis C, ... Franco R, et al. Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors. The Journal of Biological Chemistry. 277: 18091-7. PMID 11872740 DOI: 10.1074/jbc.M107731200  0.34
Low-probability matches (unlikely to be authored by this person)
2012 González S, Moreno-Delgado D, Moreno E, Pérez-Capote K, Franco R, Mallol J, Cortés A, Casadó V, Lluís C, Ortiz J, Ferré S, Canela E, McCormick PJ. Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland. Plos Biology. 10: e1001347. PMID 22723743 DOI: 10.1371/Journal.Pbio.1001347  0.299
2011 Vendrell M, Molero A, González S, Pérez-Capote K, Lluis C, McCormick PJ, Franco R, Cortés A, Casadó V, Albericio F, Royo M. Biotin ergopeptide probes for dopamine receptors. Journal of Medicinal Chemistry. 54: 1080-90. PMID 21280602 DOI: 10.1021/Jm101566D  0.298
2015 Navarro G, Borroto-Escuela DO, Fuxe K, Franco R. Purinergic signaling in Parkinson's disease. Relevance for treatment. Neuropharmacology. PMID 26211977 DOI: 10.1016/J.Neuropharm.2015.07.024  0.298
2013 Navarro G, Moreno E, Bonaventura J, Brugarolas M, Farré D, Aguinaga D, Mallol J, Cortés A, Casadó V, Lluís C, Ferre S, Franco R, Canela E, McCormick PJ. Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers. Plos One. 8: e61245. PMID 23637801 DOI: 10.1371/Journal.Pone.0061245  0.297
2014 Farré D, Muñoz A, Moreno E, Reyes-Resina I, Canet-Pons J, Dopeso-Reyes IG, Rico AJ, Lluís C, Mallol J, Navarro G, Canela EI, Cortés A, Labandeira-García JL, Casadó V, Lanciego JL, ... Franco R, et al. Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia. Molecular Neurobiology. PMID 25344317 DOI: 10.1007/s12035-014-8936-x  0.297
2004 Ciruela F, Burgueño J, Casadó V, Canals M, Marcellino D, Goldberg SR, Bader M, Fuxe K, Agnati LF, Lluis C, Franco R, Ferré S, Woods AS. Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors. Analytical Chemistry. 76: 5354-63. PMID 15362892 DOI: 10.1021/Ac049295F  0.297
2009 Vendrell M, Soriano A, Casadó V, Díaz JL, Lavilla R, Canela EI, Lluís C, Franco R, Albericio F, Royo M. Indoloquinolizidine-peptide hybrids as multiple agonists for D1 and D2 dopamine receptors. Chemmedchem. 4: 1514-22. PMID 19557804 DOI: 10.1002/Cmdc.200900149  0.295
2008 Marcellino D, Ferré S, Casadó V, Cortés A, Le Foll B, Mazzola C, Drago F, Saur O, Stark H, Soriano A, Barnes C, Goldberg SR, Lluis C, Fuxe K, Franco R. Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. The Journal of Biological Chemistry. 283: 26016-25. PMID 18644790 DOI: 10.1074/jbc.M710349200  0.294
2005 Canals M, Angulo E, Casadó V, Canela EI, Mallol J, Viñals F, Staines W, Tinner B, Hillion J, Agnati L, Fuxe K, Ferré S, Lluis C, Franco R. Molecular mechanisms involved in the adenosine A and A receptor-induced neuronal differentiation in neuroblastoma cells and striatal primary cultures. Journal of Neurochemistry. 92: 337-48. PMID 15663481 DOI: 10.1111/j.1471-4159.2004.02856.x  0.294
2014 Bonaventura J, Rico AJ, Moreno E, Sierra S, Sánchez M, Luquin N, Farré D, Müller CE, Martínez-Pinilla E, Cortés A, Mallol J, Armentero MT, Pinna A, Canela EI, Lluís C, ... ... Franco R, et al. L-DOPA-treatment in primates disrupts the expression of A(2A) adenosine-CB(1) cannabinoid-D(2) dopamine receptor heteromers in the caudate nucleus. Neuropharmacology. 79: 90-100. PMID 24230991 DOI: 10.1016/J.Neuropharm.2013.10.036  0.292
2011 Justinová Z, Ferré S, Redhi GH, Mascia P, Stroik J, Quarta D, Yasar S, Müller CE, Franco R, Goldberg SR. Reinforcing and neurochemical effects of cannabinoid CB1 receptor agonists, but not cocaine, are altered by an adenosine A2A receptor antagonist. Addiction Biology. 16: 405-15. PMID 21054689 DOI: 10.1111/J.1369-1600.2010.00258.X  0.29
2009 Soriano A, Vendrell M, Gonzalez S, Mallol J, Albericio F, Royo M, Lluís C, Canela EI, Franco R, Cortés A, Casadó V. A hybrid indoloquinolizidine peptide as allosteric modulator of dopamine D1 receptors. The Journal of Pharmacology and Experimental Therapeutics. 332: 876-85. PMID 20026675 DOI: 10.1124/Jpet.109.158824  0.29
2019 Martínez-Pinilla E, Aguinaga D, Navarro G, Rico AJ, Oyarzábal J, Sánchez-Arias JA, Lanciego JL, Franco R. Targeting CB and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson's Disease. Molecular Neurobiology. PMID 30687889 DOI: 10.1007/s12035-019-1495-4  0.29
2021 Rivas-Santisteban R, Lillo J, Muñoz A, Rodríguez-Pérez AI, Labandeira-García JL, Navarro G, Franco R. Novel Interactions Involving the Mas Receptor Show Potential of the Renin-Angiotensin system in the Regulation of Microglia Activation: Altered Expression in Parkinsonism and Dyskinesia. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33474655 DOI: 10.1007/s13311-020-00986-4  0.29
2017 Navarro G, Borroto-Escuela D, Angelats E, Etayo Í, Reyes-Resina I, Pulido-Salgado M, Rodriguez-Perez AI, Canela EI, Saura J, Lanciego JL, Labandeira-García JL, Saura CA, Fuxe K, Franco R. Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer's disease and levodopa-induced dyskinesia. Brain, Behavior, and Immunity. PMID 28843453 DOI: 10.1016/J.Bbi.2017.08.015  0.29
2015 Aymerich MS, Rojo-Bustamante E, Molina C, Celorrio M, Sánchez-Arias JA, Franco R. Neuroprotective Effect of JZL184 in MPP(+)-Treated SH-SY5Y Cells Through CB2 Receptors. Molecular Neurobiology. PMID 25976369 DOI: 10.1007/s12035-015-9213-3  0.288
2010 Ferré S, Navarro G, Casadó V, Cortés A, Mallol J, Canela EI, Lluís C, Franco R. G protein-coupled receptor heteromers as new targets for drug development. Progress in Molecular Biology and Translational Science. 91: 41-52. PMID 20691958 DOI: 10.1016/S1877-1173(10)91002-8  0.283
2007 Vendrell M, Angulo E, Casadó V, Lluis C, Franco R, Albericio F, Royo M. Novel ergopeptides as dual ligands for adenosine and dopamine receptors. Journal of Medicinal Chemistry. 50: 3062-9. PMID 17539620 DOI: 10.1021/Jm060947X  0.28
2021 Navarro G, Gonzalez A, Sánchez-Morales A, Casajuana-Martin N, Gómez-Ventura M, Cordomí A, Busqué F, Alibés R, Pardo L, Franco R. Design of Negative and Positive Allosteric Modulators of the Cannabinoid CB Receptor Derived from the Natural Product Cannabidiol. Journal of Medicinal Chemistry. PMID 34161090 DOI: 10.1021/acs.jmedchem.1c00561  0.279
2005 Fuxe K, Ferré S, Canals M, Torvinen M, Terasmaa A, Marcellino D, Goldberg SR, Staines W, Jacobsen KX, Lluis C, Woods AS, Agnati LF, Franco R. Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function. Journal of Molecular Neuroscience : Mn. 26: 209-20. PMID 16012194 DOI: 10.1385/Jmn:26:2-3:209  0.277
2009 Soriano A, Ventura R, Molero A, Hoen R, Casadó V, Cortés A, Fanelli F, Albericio F, Lluís C, Franco R, Royo M. Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers. Journal of Medicinal Chemistry. 52: 5590-602. PMID 19711895 DOI: 10.1021/Jm900298C  0.276
2015 Franco R, Casadó-Anguera V, Muñoz A, Petrovic M, Navarro G, Moreno E, Lanciego JL, Labandeira-García JL, Cortés A, Casadó V. Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum. Molecular Neurobiology. PMID 26452359 DOI: 10.1007/s12035-015-9468-8  0.275
2010 Franco R, Seeman P, Barrera C, Aymerich MS. Cocaine self-administration markedly increases dopamine D2 receptor negative cooperativity for dopamine binding: A receptor dimer-based analysis. Synapse (New York, N.Y.). 64: 566-9. PMID 20336632 DOI: 10.1002/syn.20775  0.275
2014 Sierra S, Luquin N, Rico AJ, Gómez-Bautista V, Roda E, Dopeso-Reyes IG, Vázquez A, Martínez-Pinilla E, Labandeira-García JL, Franco R, Lanciego JL. Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism. Brain Structure & Function. PMID 24972960 DOI: 10.1007/s00429-014-0823-8  0.274
2014 Navarro G, Borroto-Escuela DO, Fuxe K, Franco R. Potential of caveolae in the therapy of cardiovascular and neurological diseases. Frontiers in Physiology. 5: 370. PMID 25324780 DOI: 10.3389/Fphys.2014.00370  0.274
2017 Martínez-Pinilla E, Varani K, Reyes-Resina I, Angelats E, Vincenzi F, Ferreiro-Vera C, Oyarzabal J, Canela EI, Lanciego JL, Nadal X, Navarro G, Borea PA, Franco R. Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors. Frontiers in Pharmacology. 8: 744. PMID 29109685 DOI: 10.3389/fphar.2017.00744  0.273
2013 Pazos MR, Mohammed N, Lafuente H, Santos M, Martínez-Pinilla E, Moreno E, Valdizan E, Romero J, Pazos A, Franco R, Hillard CJ, Alvarez FJ, Martínez-Orgado J. Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors. Neuropharmacology. 71: 282-91. PMID 23587650 DOI: 10.1016/j.neuropharm.2013.03.027  0.268
2007 Quarta D, Ciruela F, Patkar K, Borycz J, Solinas M, Lluis C, Franco R, Wise RA, Goldberg SR, Hope BT, Woods AS, Ferré S. Heteromeric nicotinic acetylcholine-dopamine autoreceptor complexes modulate striatal dopamine release. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 35-42. PMID 16710311 DOI: 10.1038/Sj.Npp.1301103  0.263
2008 Briddon SJ, Gandía J, Amaral OB, Ferré S, Lluís C, Franco R, Hill SJ, Ciruela F. Plasma membrane diffusion of G protein-coupled receptor oligomers. Biochimica Et Biophysica Acta. 1783: 2262-8. PMID 18691614 DOI: 10.1016/J.Bbamcr.2008.07.006  0.261
2019 Franco R, Reyes-Resina I, Aguinaga D, Lillo A, Jiménez J, Raïch I, Borroto-Escuela DO, Ferreiro-Vera C, Canela EI, Sánchez de Medina V, Del Ser-Badia A, Fuxe K, Saura CA, Navarro G. Potentiation of cannabinoid signaling in microglia by adenosine A receptor antagonists. Glia. PMID 31429130 DOI: 10.1002/Glia.23694  0.261
2019 Reyes-Resina I, Jiménez J, Navarro G, Franco R. Identification of Heteroreceptors Complexes and Signal Transduction Events Using Bioluminescence Resonance Energy Transfer (BRET). Bio-Protocol. 9: e3385. PMID 33654881 DOI: 10.21769/BioProtoc.3385  0.259
2009 Ferré S, Franco R. Oligomerization of G-protein-coupled receptors: a reality. Current Opinion in Pharmacology. 10: 1-5. PMID 20015687 DOI: 10.1016/j.coph.2009.11.002  0.257
2018 Borroto-Escuela DO, Hinz S, Navarro G, Franco R, Müller CE, Fuxe K. Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation. Frontiers in Neuroscience. 12: 43. PMID 29467608 DOI: 10.3389/Fnins.2018.00043  0.256
2014 Zamarbide M, Etayo-Labiano I, Ricobaraza A, Martínez-Pinilla E, Aymerich MS, Luis Lanciego J, Pérez-Mediavilla A, Franco R. GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells. Hippocampus. 24: 733-9. PMID 24550142 DOI: 10.1002/Hipo.22263  0.253
2011 Ferré S, Quiroz C, Orru M, Guitart X, Navarro G, Cortés A, Casadó V, Canela EI, Lluis C, Franco R. Adenosine A(2A) Receptors and A(2A) Receptor Heteromers as Key Players in Striatal Function. Frontiers in Neuroanatomy. 5: 36. PMID 21731559 DOI: 10.3389/fnana.2011.00036  0.25
2020 Reyes-Resina I, Awad Alkozi H, Del Ser-Badia A, Sánchez-Naves J, Lillo J, Jiménez J, Pintor J, Navarro G, Franco R. Expression of Melatonin and Dopamine D Receptor Heteromers in Eye Ciliary Body Epithelial Cells and Negative Correlation with Ocular Hypertension. Cells. 9. PMID 31936298 DOI: 10.3390/cells9010152  0.248
2022 Casajuana-Martin N, Navarro G, Gonzalez A, Llinas Del Torrent C, Gómez-Autet M, Quintana García A, Franco R, Pardo L. A Single Point Mutation Blocks the Entrance of Ligands to the Cannabinoid CB Receptor via the Lipid Bilayer. Journal of Chemical Information and Modeling. PMID 36302505 DOI: 10.1021/acs.jcim.2c00865  0.248
2019 Gallo M, Navarro G, Franco R, Andreu D. A Receptor Homodimer-Disrupting Sequence Efficiently Delivered by a Protease-Resistant, Cyclic CPP Vector. International Journal of Molecular Sciences. 20. PMID 31590403 DOI: 10.3390/Ijms20194937  0.246
2018 Angelats E, Requesens M, Aguinaga D, Kreutz MR, Franco R, Navarro G. Neuronal Calcium and cAMP Cross-Talk Mediated by Cannabinoid CB Receptor and EF-Hand Calcium Sensor Interactions. Frontiers in Cell and Developmental Biology. 6: 67. PMID 30073165 DOI: 10.3389/fcell.2018.00067  0.245
2016 Navarro G, Cordomí A, Zelman-Femiak M, Brugarolas M, Moreno E, Aguinaga D, Perez-Benito L, Cortés A, Casadó V, Mallol J, Canela EI, Lluís C, Pardo L, García-Sáez AJ, McCormick PJ, ... Franco R, et al. Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs. Bmc Biology. 14: 26. PMID 27048449 DOI: 10.1186/S12915-016-0247-4  0.244
2013 Franco R, Martínez-Pinilla E, Ricobaraza A, McCormick PJ. Challenges in the development of heteromer-GPCR-based drugs. Progress in Molecular Biology and Translational Science. 117: 143-62. PMID 23663968 DOI: 10.1016/B978-0-12-386931-9.00006-4  0.244
2009 Casadó V, Cortés A, Mallol J, Pérez-Capote K, Ferré S, Lluis C, Franco R, Canela EI. GPCR homomers and heteromers: a better choice as targets for drug development than GPCR monomers? Pharmacology & Therapeutics. 124: 248-57. PMID 19664655 DOI: 10.1016/j.pharmthera.2009.07.005  0.244
2004 Agnati LF, Leo G, Vergoni AV, Martínez E, Hockemeyer J, Lluis C, Franco R, Fuxe K, Ferré S. Neuroprotective effect of L-DOPA co-administered with the adenosine A2A receptor agonist CGS 21680 in an animal model of Parkinson's disease. Brain Research Bulletin. 64: 155-64. PMID 15342103 DOI: 10.1016/j.brainresbull.2004.06.003  0.243
2009 Ferré S, Baler R, Bouvier M, Caron MG, Devi LA, Durroux T, Fuxe K, George SR, Javitch JA, Lohse MJ, Mackie K, Milligan G, Pfleger KD, Pin JP, Volkow ND, ... ... Franco R, et al. Building a new conceptual framework for receptor heteromers. Nature Chemical Biology. 5: 131-4. PMID 19219011 DOI: 10.1038/Nchembio0309-131  0.241
2016 Valenzuela R, Costa-Besada MA, Iglesias-Gonzalez J, Perez-Costas E, Villar-Cheda B, Garrido-Gil P, Melendez-Ferro M, Soto-Otero R, Lanciego JL, Henrion D, Franco R, Labandeira-Garcia JL. Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration. Cell Death & Disease. 7: e2427. PMID 27763643 DOI: 10.1038/Cddis.2016.327  0.24
2018 García-Gutiérrez MS, Navarrete F, Navarro G, Reyes-Resina I, Franco R, Lanciego JL, Giner S, Manzanares J. Alterations in Gene and Protein Expression of Cannabinoid CB2 and GPR55 Receptors in the Dorsolateral Prefrontal Cortex of Suicide Victims. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 29435814 DOI: 10.1007/s13311-018-0610-y  0.238
2016 Borroto-Escuela DO, Wydra K, Pintsuk J, Narvaez M, Corrales F, Zaniewska M, Agnati LF, Franco R, Tanganelli S, Ferraro L, Filip M, Fuxe K. Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes. Neural Plasticity. 2016: 4827268. PMID 27872762 DOI: 10.1155/2016/4827268  0.237
2016 Rodrigues RJ, Almeida T, Díaz-Hernández M, Marques JM, Franco R, Solsona C, Miras-Portugal MT, Ciruela F, Cunha RA. Presynaptic P2X1-3 and α3-containing Nicotinic Receptors Assemble Into Functionally Interacting Ion Channels in the Rat Hippocampus. Neuropharmacology. PMID 26801076 DOI: 10.1016/J.Neuropharm.2016.01.022  0.235
2014 Brugarolas M, Navarro G, Martínez-Pinilla E, Angelats E, Casadó V, Lanciego JL, Franco R. G-protein-coupled receptor heteromers as key players in the molecular architecture of the central nervous system. Cns Neuroscience & Therapeutics. 20: 703-9. PMID 24809909 DOI: 10.1111/cns.12277  0.233
2005 Agnati LF, Fuxe K, Torvinen M, Genedani S, Franco R, Watson S, Nussdorfer GG, Leo G, Guidolin D. New methods to evaluate colocalization of fluorophores in immunocytochemical preparations as exemplified by a study on A2A and D2 receptors in Chinese hamster ovary cells. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 53: 941-53. PMID 16055748 DOI: 10.1369/jhc.4A6355.2005  0.231
2019 Rodriguez-Perez AI, Garrido-Gil P, Pedrosa MA, Garcia-Garrote M, Valenzuela R, Navarro G, Franco R, Labandeira-Garcia JL. Angiotensin type 2 receptors: role in aging and neuroinflammation in the substantia nigra. Brain, Behavior, and Immunity. PMID 31863823 DOI: 10.1016/j.bbi.2019.12.011  0.23
2007 Marcellino D, Roberts DC, Navarro G, Filip M, Agnati L, Lluís C, Franco R, Fuxe K. Increase in A2A receptors in the nucleus accumbens after extended cocaine self-administration and its disappearance after cocaine withdrawal. Brain Research. 1143: 208-20. PMID 17320828 DOI: 10.1016/j.brainres.2007.01.079  0.227
2011 Orru M, Bakešová J, Brugarolas M, Quiroz C, Beaumont V, Goldberg SR, Lluís C, Cortés A, Franco R, Casadó V, Canela EI, Ferré S. Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists. Plos One. 6: e16088. PMID 21264319 DOI: 10.1371/journal.pone.0016088  0.225
2011 Cristóvão-Ferreira S, Navarro G, Brugarolas M, Pérez-Capote K, Vaz SH, Fattorini G, Conti F, Lluis C, Ribeiro JA, McCormick PJ, Casadó V, Franco R, Sebastião AM. Modulation of GABA transport by adenosine A1R-A2AR heteromers, which are coupled to both Gs- and G(i/o)-proteins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15629-39. PMID 22049406 DOI: 10.1523/Jneurosci.2526-11.2011  0.224
2016 Celorrio M, Fernández-Suárez D, Rojo-Bustamante E, Echeverry-Alzate V, Ramírez MJ, Hillard CJ, López-Moreno JA, Maldonado R, Oyarzábal J, Franco R, Aymerich MS. Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinsońs disease. Brain, Behavior, and Immunity. PMID 27318096 DOI: 10.1016/J.Bbi.2016.06.010  0.223
2004 Pacheco R, Ciruela F, Casadó V, Mallol J, Gallart T, Lluis C, Franco R. Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation Journal of Biological Chemistry. 279: 33352-33358. PMID 15184389 DOI: 10.1074/Jbc.M401761200  0.222
2022 Lillo J, Raïch I, Silva L, Zafra DA, Lillo A, Ferreiro-Vera C, Sánchez de Medina V, Martínez-Orgado J, Franco R, Navarro G. Regulation of Expression of Cannabinoid CB and Serotonin 5HT Receptor Complexes by Cannabinoids in Animal Models of Hypoxia and in Oxygen/Glucose-Deprived Neurons. International Journal of Molecular Sciences. 23. PMID 36077095 DOI: 10.3390/ijms23179695  0.219
2008 Carriba P, Navarro G, Ciruela F, Ferré S, Casadó V, Agnati L, Cortés A, Mallol J, Fuxe K, Canela EI, Lluís C, Franco R. Detection of heteromerization of more than two proteins by sequential BRET-FRET. Nature Methods. 5: 727-33. PMID 18587404 DOI: 10.1038/Nmeth.1229  0.218
2018 Borroto-Escuela DO, Perez De La Mora M, Manger P, Narváez M, Beggiato S, Crespo-Ramírez M, Navarro G, Wydra K, Díaz-Cabiale Z, Rivera A, Ferraro L, Tanganelli S, Filip M, Franco R, Fuxe K. Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors. Frontiers in Synaptic Neuroscience. 10: 20. PMID 30042672 DOI: 10.3389/Fnsyn.2018.00020  0.217
2013 Cristóvão-Ferreira S, Navarro G, Brugarolas M, Pérez-Capote K, Vaz SH, Fattorini G, Conti F, Lluis C, Ribeiro JA, McCormick PJ, Casadó V, Franco R, Sebastião AM. A1R-A2AR heteromers coupled to Gs and G i/0 proteins modulate GABA transport into astrocytes. Purinergic Signalling. 9: 433-49. PMID 23657626 DOI: 10.1007/S11302-013-9364-5  0.216
2011 Lanciego JL, Barroso-Chinea P, Rico AJ, Conte-Perales L, Callén L, Roda E, Gómez-Bautista V, López IP, Lluis C, Labandeira-García JL, Franco R. Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis. Journal of Psychopharmacology (Oxford, England). 25: 97-104. PMID 20488834 DOI: 10.1177/0269881110367732  0.214
2019 Franco R, Villa M, Morales P, Reyes-Resina I, Gutiérrez-Rodríguez A, Jiménez J, Jagerovic N, Martínez-Orgado J, Navarro G. Increased expression of cannabinoid CB and serotonin 5-HT heteroreceptor complexes in a model of newborn hypoxic-ischemic brain damage. Neuropharmacology. PMID 30738036 DOI: 10.1016/j.neuropharm.2019.02.004  0.213
2012 Luquin N, Sierra S, Rico AJ, Gómez-Bautista V, Roda E, Conte-Perales L, Franco R, McCormick P, Labandeira-García JL, Lanciego JL. Unmasking adenosine 2A receptors (A2ARs) in monkey basal ganglia output neurons using cholera toxin subunit B (CTB). Neurobiology of Disease. 47: 347-57. PMID 22659306 DOI: 10.1016/J.Nbd.2012.05.006  0.213
2016 Rico AJ, Dopeso-Reyes IG, Martínez-Pinilla E, Sucunza D, Pignataro D, Roda E, Marín-Ramos D, Labandeira-García JL, George SR, Franco R, Lanciego JL. Neurochemical evidence supporting dopamine D1-D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation. Brain Structure & Function. PMID 27612857 DOI: 10.1007/S00429-016-1306-X  0.212
2014 Cerri S, Levandis G, Ambrosi G, Montepeloso E, Antoninetti GF, Franco R, Lanciego JL, Baqi Y, Müller CE, Pinna A, Blandini F, Armentero MT. Neuroprotective potential of adenosine A2A and cannabinoid CB1 receptor antagonists in an animal model of Parkinson disease. Journal of Neuropathology and Experimental Neurology. 73: 414-24. PMID 24709676 DOI: 10.1097/Nen.0000000000000064  0.211
2014 Fernández-Suárez D, Celorrio M, Riezu-Boj JI, Ugarte A, Pacheco R, González H, Oyarzabal J, Hillard CJ, Franco R, Aymerich MS. The monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model. Neurobiology of Aging. 35: 2603-16. PMID 24973119 DOI: 10.1016/j.neurobiolaging.2014.05.021  0.208
2022 Zamarbide M, Martinez-Pinilla E, Gil-Bea F, Yanagisawa M, Franco R, Perez-Mediavilla A. Genetic Inactivation of Free Fatty Acid Receptor 3 Impedes Behavioral Deficits and Pathological Hallmarks in the APP Alzheimer's Disease Mouse Model. International Journal of Molecular Sciences. 23. PMID 35408893 DOI: 10.3390/ijms23073533  0.207
2007 Ocaña E, Delgado-Pérez L, Campos-Caro A, Muñóz J, Paz A, Franco R, Brieva JA. The prognostic role of CXCR3 expression by chronic lymphocytic leukemia B cells. Haematologica. 92: 349-56. PMID 17339184  0.205
2020 Franco R, Rivas-Santisteban R, Serrano-Marín J, Rodríguez-Pérez AI, Labandeira-García JL, Navarro G. SARS-CoV-2 as a Factor to Disbalance the Renin-Angiotensin System: A Suspect in the Case of Exacerbated IL-6 Production. Journal of Immunology (Baltimore, Md. : 1950). PMID 32680957 DOI: 10.4049/jimmunol.2000642  0.204
2020 Rivas-Santisteban R, Rodriguez-Perez AI, Muñoz A, Reyes-Resina I, Labandeira-García JL, Navarro G, Franco R. Angiotensin AT and AT receptor heteromer expression in the hemilesioned rat model of Parkinson's disease that increases with levodopa-induced dyskinesia. Journal of Neuroinflammation. 17: 243. PMID 32807174 DOI: 10.1186/s12974-020-01908-z  0.202
2020 Martínez-Pinilla E, Rico AJ, Rivas-Santisteban R, Lillo J, Roda E, Navarro G, Franco R, Lanciego JL. Expression of cannabinoid CB R-GPR55 heteromers in neuronal subtypes of the Macaca fascicularis striatum. Annals of the New York Academy of Sciences. PMID 32594556 DOI: 10.1111/nyas.14413  0.202
2016 Perreault ML, Hasbi A, Shen MY, Fan T, Navarro G, Fletcher PJ, Franco R, Lanciego JL, George SR. Disruption of a dopamine receptor complex amplifies the actions of cocaine. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 27480020 DOI: 10.1016/J.Euroneuro.2016.07.008  0.2
2008 Gandía J, Lluís C, Ferré S, Franco R, Ciruela F. Light resonance energy transfer-based methods in the study of G protein-coupled receptor oligomerization. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 30: 82-9. PMID 18081019 DOI: 10.1002/Bies.20682  0.196
2017 Celorrio M, Rojo-Bustamante E, Fernández-Suárez D, Sáez E, Estella-Hermoso de Mendoza A, Müller CE, Ramírez MJ, Oyarzábal J, Franco R, Aymerich MS. GPR55: A therapeutic target for Parkinson's disease? Neuropharmacology. PMID 28807673 DOI: 10.1016/J.Neuropharm.2017.08.017  0.195
2010 Navarro G, Moreno E, Aymerich M, Marcellino D, McCormick PJ, Mallol J, Cortés A, Casadó V, Canela EI, Ortiz J, Fuxe K, Lluís C, Ferré S, Franco R. Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine. Proceedings of the National Academy of Sciences of the United States of America. 107: 18676-81. PMID 20956312 DOI: 10.1073/Pnas.1008911107  0.193
2007 Franco R, Pacheco R, Lluis C, Ahern GP, O'Connell PJ. The emergence of neurotransmitters as immune modulators. Trends in Immunology. 28: 400-7. PMID 17689291 DOI: 10.1016/J.It.2007.07.005  0.192
2018 Franco R, Aguinaga D, Reyes I, Canela EI, Lillo J, Tarutani A, Hasegawa M, Del Ser-Badia A, Del Rio JA, Kreutz MR, Saura CA, Navarro G. -Methyl-D-Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein, Tau, and Phospho-Tau in Non-transgenic and Transgenic APP Mice. Frontiers in Molecular Neuroscience. 11: 273. PMID 30233307 DOI: 10.3389/fnmol.2018.00273  0.192
2017 Franco R, Martínez-Pinilla E, Navarro G, Zamarbide M. Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease. Progress in Neurobiology. PMID 28189739 DOI: 10.1016/J.Pneurobio.2017.01.004  0.183
2021 Valenzuela R, Rodriguez-Perez AI, Costa-Besada MA, Rivas-Santisteban R, Garrido-Gil P, Lopez-Lopez A, Navarro G, Lanciego JL, Franco R, Labandeira-Garcia JL. An ACE2/Mas-related receptor MrgE axis in dopaminergic neuron mitochondria. Redox Biology. 46: 102078. PMID 34333284 DOI: 10.1016/j.redox.2021.102078  0.18
2010 Marcellino D, Navarro G, Sahlholm K, Nilsson J, Agnati LF, Canela EI, Lluís C, Ã…rhem P, Franco R, Fuxe K. Cocaine produces D2R-mediated conformational changes in the adenosine A(2A)R-dopamine D2R heteromer. Biochemical and Biophysical Research Communications. 394: 988-92. PMID 20307491 DOI: 10.1016/J.Bbrc.2010.03.104  0.177
2007 Giménez-Llort L, Schiffmann SN, Shmidt T, Canela L, Camón L, Wassholm M, Canals M, Terasmaa A, Fernández-Teruel A, Tobeña A, Popova E, Ferré S, Agnati L, Ciruela F, Martínez E, ... ... Franco R, et al. Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain. Neurobiology of Learning and Memory. 87: 42-56. PMID 16824773 DOI: 10.1016/J.Nlm.2006.05.004  0.177
2014 Moreno B, Lopez I, Fernández-Díez B, Gottlieb M, Matute C, Sánchez-Gómez MV, Domercq M, Giralt A, Alberch J, Collon KW, Zhang H, Parent JM, Teixido M, Giralt E, Ceña V, ... ... Franco R, et al. Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine. Plos One. 9: e90671. PMID 24599318 DOI: 10.1371/Journal.Pone.0090671  0.164
2021 Osorio-Barrios F, Navarro G, Campos J, Ugalde V, Prado C, Raïch I, Contreras F, López E, Espinoza A, Lladser A, Franco R, Pacheco R. The heteromeric complex formed by dopamine receptor D5 and CCR9 leads the gut-homing of CD4 T-cells upon inflammation. Cellular and Molecular Gastroenterology and Hepatology. PMID 33864900 DOI: 10.1016/j.jcmgh.2021.04.006  0.161
2004 Duflot S, Riera B, Fernández-Veledo S, Casadó V, Norman RI, Casado FJ, Lluís C, Franco R, Pastor-Anglada M. ATP-sensitive K(+) channels regulate the concentrative adenosine transporter CNT2 following activation by A(1) adenosine receptors. Molecular and Cellular Biology. 24: 2710-9. PMID 15024061  0.158
2006 Pacheco R, Oliva H, Martinez-Navío JM, Climent N, Ciruela F, Gatell JM, Gallart T, Mallol J, Lluis C, Franco R. Glutamate released by dendritic cells as a novel modulator of T cell activation. Journal of Immunology (Baltimore, Md. : 1950). 177: 6695-704. PMID 17082582 DOI: 10.4049/Jimmunol.177.10.6695  0.158
2006 Hove-Madsen L, Prat-Vidal C, Llach A, Ciruela F, Casadó V, Lluis C, Bayes-Genis A, Cinca J, Franco R. Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release. Cardiovascular Research. 72: 292-302. PMID 17014834 DOI: 10.1016/J.Cardiores.2006.07.020  0.154
2006 Filip M, Frankowska M, Zaniewska M, PrzegaliÅ„ski E, Muller CE, Agnati L, Franco R, Roberts DC, Fuxe K. Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine. Brain Research. 1077: 67-80. PMID 16516871 DOI: 10.1016/j.brainres.2006.01.038  0.151
2016 Naval-Macabuhay I, Casanova V, Navarro G, García F, León A, Miralles L, Rovira C, Martinez-Navio JM, Gallart T, Mallol J, Gatell JM, Lluís C, Franco R, McCormick PJ, Climent N. Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1. Journal of Leukocyte Biology. 99: 349-59. PMID 26310829 DOI: 10.1189/Jlb.3A1214-580Rr  0.149
2013 Solas M, Francis PT, Franco R, Ramirez MJ. CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients. Neurobiology of Aging. 34: 805-8. PMID 22763024 DOI: 10.1016/J.Neurobiolaging.2012.06.005  0.142
2011 Llach A, Molina CE, Prat-Vidal C, Fernandes J, Casadó V, Ciruela F, Lluís C, Franco R, Cinca J, Hove-Madsen L. Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors. European Heart Journal. 32: 721-9. PMID 21177700 DOI: 10.1093/Eurheartj/Ehq464  0.139
2015 Gómez-Vallejo V, Ugarte A, García-Barroso C, Cuadrado-Tejedor M, Szczupak B, Dopeso-Reyes IG, Lanciego JL, García-Osta A, Llop J, Oyarzabal J, Franco R. Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels. Journal of Neurochemistry. PMID 26641206 DOI: 10.1111/jnc.13454  0.136
2013 Zamarbide M, Martinez-Pinilla E, Ricobaraza A, Aragón T, Franco R, Pérez-Mediavilla A. Phenyl acyl acids attenuate the unfolded protein response in tunicamycin-treated neuroblastoma cells. Plos One. 8: e71082. PMID 23976981 DOI: 10.1371/Journal.Pone.0071082  0.131
2013 Fernández-Suárez D, Celorrio M, Lanciego JL, Franco R, Aymerich MS. Loss of parvalbumin-positive neurons from the globus pallidus in animal models of Parkinson disease. Journal of Neuropathology and Experimental Neurology. 71: 973-82. PMID 23044920 DOI: 10.1097/NEN.0b013e3182717cba  0.128
2020 Martínez-Pinilla E, Rico AJ, Rivas-Santisteban R, Lillo J, Roda E, Navarro G, Lanciego JL, Franco R. Expression of GPR55 and either cannabinoid CB or CB heteroreceptor complexes in the caudate, putamen, and accumbens nuclei of control, parkinsonian, and dyskinetic non-human primates. Brain Structure & Function. PMID 32691218 DOI: 10.1007/s00429-020-02116-4  0.127
2013 Cuadrado-Tejedor M, Cabodevilla JF, Zamarbide M, Gómez-Isla T, Franco R, Perez-Mediavilla A. Age-related mitochondrial alterations without neuronal loss in the hippocampus of a transgenic model of Alzheimer's disease. Current Alzheimer Research. 10: 390-405. PMID 23545067 DOI: 10.2174/1567205011310040005  0.122
2016 Cuadrado-Tejedor M, Garcia-Barroso C, Sánchez-Arias JA, Rabal O, Pérez-González M, Mederos S, Ugarte A, Franco R, Segura V, Perea G, Oyarzabal J, Garcia-Osta A. A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5, and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27550730 DOI: 10.1038/npp.2016.163  0.122
2014 Martínez-Muñoz L, Barroso R, Dyrhaug SY, Navarro G, Lucas P, Soriano SF, Vega B, Costas C, Muñoz-Fernández MÁ, Santiago C, Rodríguez Frade JM, Franco R, Mellado M. CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface. Proceedings of the National Academy of Sciences of the United States of America. 111: E1960-9. PMID 24778234 DOI: 10.1073/pnas.1322887111  0.121
2012 Casanova V, Naval-Macabuhay I, Massanella M, Rodríguez-García M, Blanco J, Gatell JM, García F, Gallart T, Lluis C, Mallol J, Franco R, Climent N, McCormick PJ. Adenosine deaminase enhances the immunogenicity of human dendritic cells from healthy and HIV-infected individuals. Plos One. 7: e51287. PMID 23240012 DOI: 10.1371/Journal.Pone.0051287  0.121
2023 Tarifa C, Jiménez-Sábado V, Franco R, Montiel J, Guerra J, Ciruela F, Hove-Madsen L. Expression and Impact of Adenosine A Receptors on Calcium Homeostasis in Human Right Atrium. International Journal of Molecular Sciences. 24. PMID 36901835 DOI: 10.3390/ijms24054404  0.12
2023 Lillo A, Serrano-Marín J, Lillo J, Raïch I, Navarro G, Franco R. Gene regulation in activated microglia by adenosine A receptor agonists: a transcriptomics study. Purinergic Signalling. PMID 36703008 DOI: 10.1007/s11302-022-09916-9  0.12
2023 Marcoli M, Agnati LF, Franco R, Cortelli P, Anderlini D, Guidolin D, Cervetto C, Maura G. Modulating brain integrative actions as a new perspective on pharmacological approaches to neuropsychiatric diseases. Frontiers in Endocrinology. 13: 1038874. PMID 36699033 DOI: 10.3389/fendo.2022.1038874  0.12
2023 Rivas-Santisteban R, Raïch I, Aguinaga D, Saura CA, Franco R, Navarro G. The Expression of Cellular Prion Protein, PrPC, Favors pTau Propagation and Blocks NMDAR Signaling in Primary Cortical Neurons. Cells. 12. PMID 36672218 DOI: 10.3390/cells12020283  0.12
2023 Rivas-Santisteban R, Lillo J, Raïch I, Muñoz A, Lillo A, Rodríguez-Pérez AI, Labandeira-García JL, Navarro G, Franco R. The cannabinoid CB receptor interacts with the angiotensin AT receptor. Overexpression of AT-CB receptor heteromers in the striatum of 6-hydroxydopamine hemilesioned rats. Experimental Neurology. 362: 114319. PMID 36632949 DOI: 10.1016/j.expneurol.2023.114319  0.12
2022 Franco R, Serrano-Marín J. The unbroken Krebs cycle. Hormonal-like regulation and mitochondrial signaling to control mitophagy and prevent cell death. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 45: e2200194. PMID 36549872 DOI: 10.1002/bies.202200194  0.12
2022 Franco R. Editorial: Rising stars in clinical microbiology: 2022. Frontiers in Cellular and Infection Microbiology. 12: 1066181. PMID 36452295 DOI: 10.3389/fcimb.2022.1066181  0.12
2022 Franco R. On the Mechanistic Perceptions of Consciousness: From Quantum Mechanics to Consciousness and Free Will and from David Bohm to Benjamin Libet. Journal of Integrative Neuroscience. 21: 153. PMID 36424755 DOI: 10.31083/j.jin2106153  0.12
2022 Raïch I, Rebassa JB, Lillo J, Cordomi A, Rivas-Santisteban R, Lillo A, Reyes-Resina I, Franco R, Navarro G. Antagonization of OX Receptor Potentiates CB Receptor Function in Microglia from APP Mice Model. International Journal of Molecular Sciences. 23. PMID 36361598 DOI: 10.3390/ijms232112801  0.12
2022 Franco R, Lillo A, Navarro G, Reyes-Resina I. The adenosine A receptor is a therapeutic target in neurological, heart and oncogenic diseases. Expert Opinion On Therapeutic Targets. 26: 791-800. PMID 36300278 DOI: 10.1080/14728222.2022.2136570  0.12
2022 Kislaya I, Machado A, Magalhães S, Rodrigues AP, Franco R, Leite PP, Dias CM, Nunes B. COVID-19 mRNA vaccine effectiveness (second and first booster dose) against hospitalisation and death during Omicron BA.5 circulation: cohort study based on electronic health records, Portugal, May to July 2022. Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin. 27. PMID 36111555 DOI: 10.2807/1560-7917.ES.2022.27.37.2200697  0.12
2022 Lillo A, Marin S, Serrano-Marín J, Binetti N, Navarro G, Cascante M, Sánchez-Navés J, Franco R. Targeted Metabolomics Shows That the Level of Glutamine, Kynurenine, Acyl-Carnitines and Lysophosphatidylcholines Is Significantly Increased in the Aqueous Humor of Glaucoma Patients. Frontiers in Medicine. 9: 935084. PMID 35935793 DOI: 10.3389/fmed.2022.935084  0.12
2022 Franco R, Serrano-Marín J. Robustness of the Krebs Cycle under Physiological Conditions and in Cancer: New Clues for Evaluating Metabolism-Modifying Drug Therapies. Biomedicines. 10. PMID 35625935 DOI: 10.3390/biomedicines10051199  0.12
2022 Lins MRDCR, Corrêa GG, Amorim LADS, Franco RAL, Ribeiro NV, Jesus VN, Pedrolli DB. Characterization of Five Purine Riboswitches in Cellular and Cell-Free Expression Systems. Current Microbiology. 79: 207. PMID 35622174 DOI: 10.1007/s00284-022-02902-9  0.12
2022 Gnad T, Navarro G, Lahesmaa M, Reverte-Salisa L, Copperi F, Cordomi A, Naumann J, Hochhäuser A, Haufs-Brusberg S, Wenzel D, Suhr F, Jespersen NZ, Scheele C, Tsvilovskyy V, Brinkmann C, ... ... Franco R, et al. Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity. Cell Metabolism. 34: 649. PMID 35385706 DOI: 10.1016/j.cmet.2022.02.014  0.12
2022 Franco R, Morales P, Navarro G, Jagerovic N, Reyes-Resina I. The Binding Mode to Orthosteric Sites and/or Exosites Underlies the Therapeutic Potential of Drugs Targeting Cannabinoid CB Receptors. Frontiers in Pharmacology. 13: 852631. PMID 35250601 DOI: 10.3389/fphar.2022.852631  0.12
2022 Lillo A, Raïch I, Lillo J, Pérez-Olives C, Navarro G, Franco R. Expression of the Adenosine A-A Receptor Heteromer in Different Brain Regions and Marked Upregulation in the Microglia of the Transgenic APP Alzheimer's Disease Model. Biomedicines. 10. PMID 35203424 DOI: 10.3390/biomedicines10020214  0.12
2021 Lillo A, Lillo J, Raïch I, Miralpeix C, Dosrius F, Franco R, Navarro G. Ghrelin and Cannabinoid Functional Interactions Mediated by Ghrelin/CB Receptor Heteromers That Are Upregulated in the Striatum From Offspring of Mice Under a High-Fat Diet. Frontiers in Cellular Neuroscience. 15: 786597. PMID 34955755 DOI: 10.3389/fncel.2021.786597  0.12
2021 Franco R, Rivas-Santisteban R, Navarro G, Reyes-Resina I. Adenosine Receptor Antagonists to Combat Cancer and to Boost Anti-Cancer Chemotherapy and Immunotherapy. Cells. 10. PMID 34831054 DOI: 10.3390/cells10112831  0.12
2021 Raïch I, Rivas-Santisteban R, Lillo A, Lillo J, Reyes-Resina I, Nadal X, Ferreiro-Vera C, de Medina VS, Majellaro M, Sotelo E, Navarro G, Franco R. Similarities and differences upon binding of naturally occurring Δ-tetrahydrocannabinol-derivatives to cannabinoid CB and CB receptors. Pharmacological Research. 174: 105970. PMID 34758399 DOI: 10.1016/j.phrs.2021.105970  0.12
2021 Rivas-Santisteban R, Lillo A, Lillo J, Rebassa JB, Contestí JS, Saura CA, Franco R, Navarro G. N-Methyl-D-aspartate (NMDA) and cannabinoid CB receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors. Alzheimer's Research & Therapy. 13: 184. PMID 34749800 DOI: 10.1186/s13195-021-00920-6  0.12
2021 Lillo J, Lillo A, Zafra DA, Miralpeix C, Rivas-Santisteban R, Casals N, Navarro G, Franco R. Identification of the Ghrelin and Cannabinoid CB Receptor Heteromer Functionality and Marked Upregulation in Striatal Neurons from Offspring of Mice under a High-Fat Diet. International Journal of Molecular Sciences. 22. PMID 34445634 DOI: 10.3390/ijms22168928  0.12
2021 Franco R, Casanovas B, Camps J, Navarro G, Martínez-Pinilla E. Antixoxidant Supplements versus Health Benefits of Brief/Intermittent Exposure to Potentially Toxic Physical or Chemical Agents. Current Issues in Molecular Biology. 43: 650-664. PMID 34287292 DOI: 10.3390/cimb43020047  0.12
2021 Franco R. Journal Enters a New Era. Current Issues in Molecular Biology. 43: 384-388. PMID 34207154 DOI: 10.3390/cimb43010031  0.12
2021 Mallo-Abreu A, Reyes-Resina I, Azuaje J, Franco R, García-Rey A, Majellaro M, Miranda-Pastoriza D, García-Mera X, Jespers W, Gutiérrez-de-Terán H, Navarro G, Sotelo E. Potent and Subtype-Selective Dopamine D Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach. Journal of Medicinal Chemistry. 64: 8710-8726. PMID 34110150 DOI: 10.1021/acs.jmedchem.1c00704  0.12
2021 Franco R, Lillo A, Rivas-Santisteban R, Reyes-Resina I, Navarro G. Microglial Adenosine Receptors: From Preconditioning to Modulating the M1/M2 Balance in Activated Cells. Cells. 10. PMID 34066933 DOI: 10.3390/cells10051124  0.12
2021 Franco R, Rivas-Santisteban R, Lillo J, Camps J, Navarro G, Reyes-Resina I. 5-Hydroxytryptamine, Glutamate, and ATP: Much More Than Neurotransmitters. Frontiers in Cell and Developmental Biology. 9: 667815. PMID 33937270 DOI: 10.3389/fcell.2021.667815  0.12
2021 Valenzuela R, Pedrosa MA, Garrido-Gil P, Labandeira CM, Navarro G, Franco R, Rodriguez-Perez AI, Labandeira-Garcia JL. Interactions between ibuprofen, ACE2, renin-angiotensin system, and spike protein in the lung. Implications for COVID-19. Clinical and Translational Medicine. 11: e371. PMID 33931961 DOI: 10.1002/ctm2.371  0.12
2021 Franco R, Rivas-Santisteban R, Navarro G, Pinna A, Reyes-Resina I. Genes Implicated in Familial Parkinson's Disease Provide a Dual Picture of Nigral Dopaminergic Neurodegeneration with Mitochondria Taking Center Stage. International Journal of Molecular Sciences. 22. PMID 33924963 DOI: 10.3390/ijms22094643  0.12
2021 Casanovas M, Reyes-Resina I, Lillo A, Lillo J, López-Arnau R, Camarasa J, Escubedo E, Navarro G, Franco R. Methamphetamine Blocks Adenosine A Receptor Activation via Sigma 1 and Cannabinoid CB Receptors. International Journal of Molecular Sciences. 22. PMID 33803075 DOI: 10.3390/ijms22052743  0.12
2021 Martínez-Pinilla E, Rubio-Sardón N, Villar-Conde S, Navarro G, Del Valle E, Tolivia J, Franco R, Navarro A. Cuprizone-Induced Neurotoxicity in Human Neural Cell Lines Is Mediated by a Reversible Mitochondrial Dysfunction: Relevance for Demyelination Models. Brain Sciences. 11. PMID 33671675 DOI: 10.3390/brainsci11020272  0.12
2021 Franco R, Cordomí A, Llinas Del Torrent C, Lillo A, Serrano-Marín J, Navarro G, Pardo L. Structure and function of adenosine receptor heteromers. Cellular and Molecular Life Sciences : Cmls. PMID 33580270 DOI: 10.1007/s00018-021-03761-6  0.12
2021 Casanovas M, Jiménez-Rosés M, Cordomí A, Lillo A, Vega-Quiroga I, Izquierdo J, Medrano M, Gysling K, Pardo L, Navarro G, Franco R. Discovery of a macromolecular complex mediating the hunger suppressive actions of cocaine: Structural and functional properties. Addiction Biology. e13017. PMID 33559278 DOI: 10.1111/adb.13017  0.12
2021 Franco R. Geoffrey Burnstock (1929-2020): the finest pharmacologist and an inspiring scientist. Purinergic Signalling. 17: 135. PMID 33528695 DOI: 10.1007/s11302-021-09769-8  0.12
2021 Franco R, Reyes-Resina I, Navarro G. Dopamine in Health and Disease: Much More Than a Neurotransmitter. Biomedicines. 9. PMID 33499192 DOI: 10.3390/biomedicines9020109  0.12
2021 Franco RA, de Almeida JP, Landoni G, Scheeren TWL, Galas FRBG, Fukushima JT, Zefferino S, Nardelli P, de Albuquerque Piccioni M, Arita ECTC, Park CHL, Cunha LCC, de Oliveira GQ, Costa IBSDS, Kalil Filho R, et al. Dobutamine-sparing versus dobutamine-to-all strategy in cardiac surgery: a randomized noninferiority trial. Annals of Intensive Care. 11: 15. PMID 33496877 DOI: 10.1186/s13613-021-00808-6  0.12
2021 Pedrosa MA, Valenzuela R, Garrido P, Labandeira CM, Navarro G, Franco R, Labandeira-Garcia JL, Rodriguez-Perez AI. Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19. Clinical Science (London, England : 1979). PMID 33479758 DOI: 10.1042/CS20201511  0.12
2021 Pérez-Olives C, Rivas-Santisteban R, Lillo J, Navarro G, Franco R. Recent Advances in the Potential of Cannabinoids for Neuroprotection in Alzheimer's, Parkinson's, and Huntington's Diseases. Advances in Experimental Medicine and Biology. 1264: 81-92. PMID 33332005 DOI: 10.1007/978-3-030-57369-0_6  0.12
2020 Franco R, Rivas-Santisteban R, Reyes-Resina I, Navarro G. The Old and New Visions of Biased Agonism Through the Prism of Adenosine Receptor Signaling and Receptor/Receptor and Receptor/Protein Interactions. Frontiers in Pharmacology. 11: 628601. PMID 33584311 DOI: 10.3389/fphar.2020.628601  0.12
2020 Franco R, Lillo A, Rivas-Santisteban R, Rodríguez-Pérez AI, Reyes-Resina I, Labandeira-García JL, Navarro G. Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue. International Journal of Molecular Sciences. 21. PMID 33339432 DOI: 10.3390/ijms21249602  0.12
2020 Serrano-Marín J, Reyes-Resina I, Martínez-Pinilla E, Navarro G, Franco R. Natural Compounds as Guides for the Discovery of Drugs Targeting G-Protein-Coupled Receptors. Molecules (Basel, Switzerland). 25. PMID 33143389 DOI: 10.3390/molecules25215060  0.12
2020 Morales P, Navarro G, Gómez-Autet M, Redondo L, Fernandez-Ruiz J, Perez-Benito L, Cordomi A, Pardo L, Franco R, Jagerovic N. Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32794211 DOI: 10.1002/chem.202003389  0.12
2020 Lillo A, Martínez-Pinilla E, Reyes-Resina I, Navarro G, Franco R. Adenosine A and A Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling. International Journal of Molecular Sciences. 21. PMID 32709103 DOI: 10.3390/ijms21145070  0.12
2020 Gnad T, Navarro G, Lahesmaa M, Reverte-Salisa L, Copperi F, Cordomi A, Naumann J, Hochhäuser A, Haufs-Brusberg S, Wenzel D, Suhr F, Jespersen NZ, Scheele C, Tsvilovskyy V, Brinkmann C, ... ... Franco R, et al. Adenosine/A2B Receptor Signaling Ameliorates the Effects of Aging and Counteracts Obesity. Cell Metabolism. PMID 32589947 DOI: 10.1016/j.cmet.2020.06.006  0.12
2020 Navarro G, Varani K, Lillo A, Vincenzi F, Rivas-Santisteban R, Raïch I, Reyes-Resina I, Ferreiro-Vera C, Borea PA, de Medina VS, Nadal X, Franco R. Pharmacological data of cannabidiol- and cannabigerol-type phytocannabinoids acting on cannabinoid CB, CB and CB/CB heteromer receptors. Pharmacological Research. 104940. PMID 32470563 DOI: 10.1016/j.phrs.2020.104940  0.12
2020 Franco R, Rivas-Santisteban R, Reyes-Resina I, Casanovas M, Pérez-Olives C, Ferreiro-Vera C, Navarro G, de Medina VS, Nadal X. Biological potential of varinic-, minor-, and acidic phytocannabinoids. Pharmacological Research. 104801. PMID 32416215 DOI: 10.1016/j.phrs.2020.104801  0.12
2020 Franco R, Rivas-Santisteban R, Casanovas M, Lillo A, Saura CA, Navarro G. Adenosine A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer's Disease. Cells. 9. PMID 32357548 DOI: 10.3390/cells9051075  0.12
2020 Franco R, Rivas-Santisteban R, Reyes-Resina I, Navarro G, Martínez-Pinilla E. Microbiota and Other Preventive Strategies and Non-genetic Risk Factors in Parkinson's Disease. Frontiers in Aging Neuroscience. 12: 12. PMID 32226375 DOI: 10.3389/fnagi.2020.00012  0.12
2020 García-Recio A, Navarro G, Franco R, Olivella M, Guixà-González R, Cordomí A. DIMERBOW: exploring possible GPCR dimer interfaces. Bioinformatics (Oxford, England). PMID 32096817 DOI: 10.1093/bioinformatics/btaa117  0.12
2020 Alkozi HA, Navarro G, Aguinaga D, Reyes-Resina I, Sanchez-Naves J, Pérez de Lara MJ, Franco R, Pintor J. Adrenergic-melatonin receptor complexes control ion homeostasis and intraocular pressure and their disruption contributes to hypertensive glaucoma. British Journal of Pharmacology. PMID 31901203 DOI: 10.1111/bph.14971  0.12
2020 Franco R, Castelló J, Canela EI. The Kinetic Component in Drug Discovery: Using the Most Basic Pharmacological Concepts to Advance in Selecting Drugs to Combat CNS Diseases. Current Neuropharmacology. 18: 250-257. PMID 31573886 DOI: 10.2174/1570159X17666191001144309  0.12
2019 Franco R, Navarro G, Martínez-Pinilla E. Antioxidants versus Food Antioxidant Additives and Food Preservatives. Antioxidants (Basel, Switzerland). 8. PMID 31717960 DOI: 10.3390/antiox8110542  0.12
2019 Alkozi HA, Navarro G, Franco R, Pintor J. Melatonin and the control of intraocular pressure. Progress in Retinal and Eye Research. 100798. PMID 31560946 DOI: 10.1016/j.preteyeres.2019.100798  0.12
2019 Aguinaga D, Casanovas M, Rivas-Santisteban R, Reyes-Resina I, Navarro G, Franco R. The sigma-1 receptor as key common factor in cocaine and food seeking behaviors. Journal of Molecular Endocrinology. PMID 31539876 DOI: 10.1530/JME-19-0138  0.12
2019 Franco R, Navarro G, Martínez-Pinilla E. Hormetic and Mitochondria-Related Mechanisms of Antioxidant Action of Phytochemicals. Antioxidants (Basel, Switzerland). 8. PMID 31487950 DOI: 10.3390/antiox8090373  0.12
2019 Franco R, Symonds ME. Editorial: Epigenetics in Mammalian Tissues. Frontiers in Genetics. 10: 635. PMID 31333720 DOI: 10.3389/fgene.2019.00635  0.12
2019 Franco R, Navarro G, Martínez-Pinilla E. Lessons on Differential Neuronal-Death-Vulnerability from Familial Cases of Parkinson's and Alzheimer's Diseases. International Journal of Molecular Sciences. 20. PMID 31277513 DOI: 10.3390/ijms20133297  0.12
2019 Franco R, Navarro G, Martínez-Pinilla E. Antioxidant Defense Mechanisms in Erythrocytes and in the Central Nervous System. Antioxidants (Basel, Switzerland). 8. PMID 30781629 DOI: 10.3390/antiox8020046  0.12
2019 Franco R, Martínez-Pinilla E, Navarro G. Why have transgenic rodent models failed to successfully mimic Alzheimer's disease. How can we develop effective drugs without them? Expert Opinion On Drug Discovery. 1-4. PMID 30775940 DOI: 10.1080/17460441.2019.1581169  0.12
2018 Navarro G, Martínez-Pinilla E, Ortiz R, Noé V, Ciudad CJ, Franco R. Resveratrol and Related Stilbenoids, Nutraceutical/Dietary Complements with Health-Promoting Actions: Industrial Production, Safety, and the Search for Mode of Action. Comprehensive Reviews in Food Science and Food Safety. 17: 808-826. PMID 33350112 DOI: 10.1111/1541-4337.12359  0.12
2018 Navarro G, Reyes-Resina I, Rivas-Santisteban R, Sánchez de Medina V, Morales P, Casano S, Ferreiro-Vera C, Lillo A, Aguinaga D, Jagerovic N, Nadal X, Franco R. Cannabidiol skews biased agonism at cannabinoid CB and CB receptors with smaller effect in CB-CB heteroreceptor complexes. Biochemical Pharmacology. PMID 30194918 DOI: 10.1016/j.bcp.2018.08.046  0.12
2018 Navarro G, Varani K, Reyes-Resina I, Sánchez de Medina V, Rivas-Santisteban R, Sánchez-Carnerero Callado C, Vincenzi F, Casano S, Ferreiro-Vera C, Canela EI, Borea PA, Nadal X, Franco R. Cannabigerol Action at Cannabinoid CB and CB Receptors and at CB-CB Heteroreceptor Complexes. Frontiers in Pharmacology. 9: 632. PMID 29977202 DOI: 10.3389/fphar.2018.00632  0.12
2018 Aguinaga D, Medrano M, Cordomí A, Jiménez-Rosés M, Angelats E, Casanovas M, Vega-Quiroga I, Canela EI, Petrovic M, Gysling K, Pardo L, Franco R, Navarro G. Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors. Molecular Neurobiology. PMID 29876881 DOI: 10.1007/s12035-018-1140-7  0.12
2018 Franco R, Navarro G. Adenosine AReceptor Antagonists in Neurodegenerative Diseases: Huge Potential and Huge Challenges. Frontiers in Psychiatry. 9: 68. PMID 29593579 DOI: 10.3389/fpsyt.2018.00068  0.12
2018 Aguinaga D, Medrano M, Vega-Quiroga I, Gysling K, Canela EI, Navarro G, Franco R. Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression. Frontiers in Molecular Neuroscience. 11: 17. PMID 29483862 DOI: 10.3389/fnmol.2018.00017  0.12
2017 Navarro G, Franco N, Martínez-Pinilla E, Franco R. The Epigenetic Cytocrin Pathway to the Nucleus. Epigenetic Factors, Epigenetic Mediators, and Epigenetic Traits. A Biochemist Perspective. Frontiers in Genetics. 8: 179. PMID 29230234 DOI: 10.3389/fgene.2017.00179  0.12
2017 Alkozi HA, Franco R, Pintor JJ. Epigenetics in the Eye: An Overview of the Most Relevant Ocular Diseases. Frontiers in Genetics. 8: 144. PMID 29075285 DOI: 10.3389/fgene.2017.00144  0.12
2017 Medrano M, Aguinaga D, Reyes-Resina I, Canela EI, Mallol J, Navarro G, Franco R. Orexin A/Hypocretin Modulates Leptin Receptor-Mediated Signaling by Allosteric Modulations Mediated by the Ghrelin GHS-R1A Receptor in Hypothalamic Neurons. Molecular Neurobiology. PMID 28717967 DOI: 10.1007/s12035-017-0670-8  0.12
2017 Franco R, Martínez-Pinilla E. Chemical rules on the assessment of antioxidant potential in food and food additives aimed at reducing oxidative stress and neurodegeneration. Food Chemistry. 235: 318-323. PMID 28554642 DOI: 10.1016/j.foodchem.2017.05.040  0.12
2017 Navarro G, Martínez-Pinilla E, Sánchez-Melgar A, Ortiz R, Noé V, Martín M, Ciudad C, Franco R. A genomics approach identifies selective effects of trans-resveratrol in cerebral cortex neuron and glia gene expression. Plos One. 12: e0176067. PMID 28441400 DOI: 10.1371/journal.pone.0176067  0.12
2017 Costa Leme A, Hajjar LA, Volpe MS, Fukushima JT, De Santis Santiago RR, Osawa EA, Pinheiro de Almeida J, Gerent AM, Franco RA, Zanetti Feltrim MI, Nozawa E, de Moraes Coimbra VR, de Moraes Ianotti R, Hashizume CS, Kalil Filho R, et al. Effect of Intensive vs Moderate Alveolar Recruitment Strategies Added to Lung-Protective Ventilation on Postoperative Pulmonary Complications: A Randomized Clinical Trial. Jama. 317: 1422-1432. PMID 28322416 DOI: 10.1001/jama.2017.2297  0.12
2017 Oñatibia-Astibia A, Franco R, Martínez-Pinilla E. Health benefits of methylxanthines in neurodegenerative diseases. Molecular Nutrition & Food Research. 61. PMID 28074613 DOI: 10.1002/mnfr.201600670  0.12
2016 Elgueta D, Aymerich MS, Contreras F, Montoya A, Celorrio M, Rojo-Bustamante E, Riquelme E, González H, Vásquez M, Franco R, Pacheco R. Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's disease. Neuropharmacology. PMID 27693549 DOI: 10.1016/j.neuropharm.2016.09.028  0.12
2016 Navarro G, Morales P, Rodríguez-Cueto C, Fernández-Ruiz J, Jagerovic N, Franco R. Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders. Frontiers in Neuroscience. 10: 406. PMID 27679556 DOI: 10.3389/fnins.2016.00406  0.12
2016 Morales P, Gómez-Cañas M, Navarro G, Hurst DP, Carrillo-Salinas FJ, Lagartera L, Pazos R, Goya P, Reggio PH, Guaza C, Franco R, Fernández-Ruiz J, Jagerovic N. Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis. Journal of Medicinal Chemistry. PMID 27309150 DOI: 10.1021/acs.jmedchem.6b00397  0.12
2016 Oñatibia-Astibia A, Martínez-Pinilla E, Franco R. The potential of methylxanthine-based therapies in pediatric respiratory tract diseases. Respiratory Medicine. 112: 1-9. PMID 26880379 DOI: 10.1016/j.rmed.2016.01.022  0.12
2016 Cordomí A, Navarro G, Aymerich MS, Franco R. Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins. Trends in Biochemical Sciences. 40: 548-551. PMID 26410595 DOI: 10.1016/j.tibs.2015.07.007  0.12
2015 Franco R, Petrovic M. Suggesting a Way to Understand the Actual Potential of Anti-Alzheimer's Disease Drugs That Show Promise in Transgenic Mouse Models. Frontiers in Neurology. 6: 206. PMID 26500603 DOI: 10.3389/fneur.2015.00206  0.12
2015 Franco R, Fernández-Suárez D. Alternatively activated microglia and macrophages in the central nervous system. Progress in Neurobiology. 131: 65-86. PMID 26067058 DOI: 10.1016/j.pneurobio.2015.05.003  0.12
2015 Franco RM, Guimaraes MD, Moreira BL, Bitencourt AG, Hochhegger B, Marchiori E. Enhancing survival with early surgical resection of endobronchial metastasis in a follow-up of ovarian carcinoma. Radiologia Brasileira. 48: 130. PMID 25987757 DOI: 10.1590/0100-3984.2013.0020  0.12
2015 Martínez-Pinilla E, Oñatibia-Astibia A, Franco R. The relevance of theobromine for the beneficial effects of cocoa consumption. Frontiers in Pharmacology. 6: 30. PMID 25750625 DOI: 10.3389/fphar.2015.00030  0.12
2014 Franco R. Enhancing cognition before clinical symptoms of dementia. Frontiers in Systems Neuroscience. 8: 240. PMID 25565993 DOI: 10.3389/fnsys.2014.00240  0.12
2014 Franco R, Cedazo-Minguez A. Successful therapies for Alzheimer's disease: why so many in animal models and none in humans? Frontiers in Pharmacology. 5: 146. PMID 25009496 DOI: 10.3389/fphar.2014.00146  0.12
2014 Franco N, Franco R. Understanding the added value of g-protein-coupled receptor heteromers. Scientifica. 2014: 362937. PMID 24864225 DOI: 10.1155/2014/362937  0.12
2013 Franco R, Oñatibia-Astibia A, Martínez-Pinilla E. Health benefits of methylxanthines in cacao and chocolate. Nutrients. 5: 4159-73. PMID 24145871 DOI: 10.3390/nu5104159  0.12
2013 Espirito Santo CV, Franco RA, Benvenuti LA. Case 1/2013: 69-year-old male patient with sudden back and lower right limb pain and shock. Arquivos Brasileiros De Cardiologia. 100: e16-20. PMID 23503833 DOI: 10.5935/abc.20130037  0.12
2013 Franco RA, Giannetti NS, Serrano CV, Nicolau JC. Use of therapeutic hypothermia in a patient with acute coronary heart disease. Arquivos Brasileiros De Cardiologia. 99: e122-4. PMID 22964901 DOI: 10.1590/s0066-782x2012001100015  0.12
2012 Da Fonseca EJ, Do Amarante EE, de S Abboud LC, Hees SJ, Franco RJ, de A Silva BJ. Fatal esophageal fibrosarcoma associated to parasitism by spirurid nematode Spirocerca lupi in a dog: a case report. Journal of Parasitic Diseases : Official Organ of the Indian Society For Parasitology. 36: 273-6. PMID 24082542 DOI: 10.1007/s12639-012-0108-1  0.12
2012 García-Osta A, Cuadrado-Tejedor M, García-Barroso C, Oyarzábal J, Franco R. Phosphodiesterases as therapeutic targets for Alzheimer's disease. Acs Chemical Neuroscience. 3: 832-44. PMID 23173065 DOI: 10.1021/cn3000907  0.12
2011 Martinez-Navio JM, Climent N, Gallart T, Lluis C, Franco R. An old enzyme for current needs: adenosine deaminase and a dendritic cell vaccine for HIV. Immunology and Cell Biology. 90: 594-600. PMID 21931337 DOI: 10.1038/icb.2011.81  0.12
2010 Martinez-Navio JM, Casanova V, Pacheco R, Naval-Macabuhay I, Climent N, Garcia F, Gatell JM, Mallol J, Gallart T, Lluis C, Franco R. Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells. Journal of Leukocyte Biology. 89: 127-36. PMID 20959412 DOI: 10.1189/jlb.1009696  0.12
2010 Casadó V, Barrondo S, Spasic M, Callado LF, Mallol J, Canela E, Lluís C, Meana J, Cortés A, Sallés J, Franco R. Gi protein coupling to adenosine A1-A2A receptor heteromers in human brain caudate nucleus. Journal of Neurochemistry. 114: 972-80. PMID 20477947 DOI: 10.1111/j.1471-4159.2010.06810.x  0.12
2010 Zavialov AV, Gracia E, Glaichenhaus N, Franco R, Zavialov AV, Lauvau G. Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages. Journal of Leukocyte Biology. 88: 279-90. PMID 20453107 DOI: 10.1189/jlb.1109764  0.12
2010 Rodríguez-García M, Climent N, Oliva H, Casanova V, Franco R, Leon A, Gatell JM, García F, Gallart T. Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression. Plos One. 5: e9436. PMID 20195543 DOI: 10.1371/journal.pone.0009436  0.12
2010 Martinez-Navio JM, Climent N, Pacheco R, Garcia F, Plana M, Nomdedeu M, Oliva H, Rovira C, Miralles L, Gatell JM, Gallart T, Mallol J, Lluis C, Franco R. Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activation. Immunology. 128: 393-404. PMID 20067539 DOI: 10.1111/j.1365-2567.2009.03121.x  0.12
2009 Franco R. [Coffee and mental health]. Atencion Primaria. 41: 578-81. PMID 19744749 DOI: 10.1016/j.aprim.2009.07.001  0.12
2009 Climent N, Martinez-Navio JM, Gil C, Garcia F, Rovira C, Hurtado C, Miralles L, Gatell JM, Gallart T, Mallol J, Lluis C, Franco R. Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIV. Immunology and Cell Biology. 87: 634-9. PMID 19668260 DOI: 10.1038/icb.2009.53  0.12
2009 Urigüen L, García-Fuster MJ, Callado LF, Morentin B, La Harpe R, Casadó V, Lluis C, Franco R, García-Sevilla JA, Meana JJ. Immunodensity and mRNA expression of A2A adenosine, D2 dopamine, and CB1 cannabinoid receptors in postmortem frontal cortex of subjects with schizophrenia: effect of antipsychotic treatment. Psychopharmacology. 206: 313-24. PMID 19652957 DOI: 10.1007/s00213-009-1608-2  0.12
2009 Casadó V, Ferrada C, Bonaventura J, Gracia E, Mallol J, Canela EI, Lluís C, Cortés A, Franco R. Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist-antagonist binding modulation. Biochemical Pharmacology. 78: 1456-63. PMID 19643089 DOI: 10.1016/j.bcp.2009.07.012  0.12
2009 Franco R. G-protein-coupled receptor heteromers or how neurons can display differently flavoured patterns in response to the same neurotransmitter. British Journal of Pharmacology. 158: 23-31. PMID 19422387 DOI: 10.1111/j.1476-5381.2009.00181.x  0.12
2009 Franco R. [Coffee and cancer]. Medicina Clinica. 131: 633-5. PMID 19080856 DOI: 10.1157/13127925  0.12
2008 Franco R. Neurotransmitter receptor heteromers in neurodegenerative diseases and neural plasticity. Journal of Neural Transmission (Vienna, Austria : 1996). 116: 983-7. PMID 19002553 DOI: 10.1007/s00702-008-0148-y  0.12
2008 Domínguez I, Franssen-Canovas B, Uribe-Uribe N, Franco R, Campuzano M, Uscanga LF. [Accessory spleen as a differential diagnosis of intrapancreatic tumors. Case report and review of the literature]. Revista De Gastroenterologia De Mexico. 72: 376-8. PMID 18595327  0.12
2008 Franco R, Pacheco R, Gatell JM, Gallart T, Lluis C. Enzymatic and extraenzymatic role of adenosine deaminase 1 in T-cell-dendritic cell contacts and in alterations of the immune function. Critical Reviews in Immunology. 27: 495-509. PMID 18197796 DOI: 10.1615/critrevimmunol.v27.i6.10  0.12
2007 Pacheco R, Gallart T, Lluis C, Franco R. Role of glutamate on T-cell mediated immunity. Journal of Neuroimmunology. 185: 9-19. PMID 17303252 DOI: 10.1016/j.jneuroim.2007.01.003  0.12
2006 Giraldo P, Latre P, Alfonso P, Acedo A, Alonso D, Barez A, Corrales A, Franco R, Roldan V, Serrano S, Pocovi M. Short-term effect of miglustat in every day clinical use in treatment-naïve or previously treated patients with type 1 Gaucher's disease. Haematologica. 91: 703-6. PMID 16627252  0.12
2005 Angulo E, Noé V, Casadó V, Mallol J, Gomez-Isla T, Lluis C, Ferrer I, Ciudad CJ, Franco R. Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease. Journal of Neurochemistry. 91: 547-57. PMID 15485486 DOI: 10.1111/j.1471-4159.2004.02771.x  0.12
2004 Angulo E, Casadó V, Mallol J, Canela EI, Viñals F, Ferrer I, Lluis C, Franco R. A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation. Brain Pathology (Zurich, Switzerland). 13: 440-51. PMID 14655750 DOI: 10.1111/j.1750-3639.2003.tb00475.x  0.12
2003 Salgado FJ, Lojo J, Alonso-Lebrero JL, Lluis C, Franco R, Cordero OJ, Nogueira M. A role for interleukin-12 in the regulation of T cell plasma membrane compartmentation. The Journal of Biological Chemistry. 278: 24849-57. PMID 12676959 DOI: 10.1074/jbc.M212978200  0.12
2013 Cuadrado-Tejedor M, Ricobaraza AL, Torrijo R, Franco R, Garcia-Osta A. Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model. Current Pharmaceutical Design. 19: 5076-84. PMID 23448463 DOI: 10.2174/1381612811319280006  0.116
2005 Ferré S, Borycz J, Goldberg SR, Hope BT, Morales M, Lluis C, Franco R, Ciruela F, Cunha R. Role of adenosine in the control of homosynaptic plasticity in striatal excitatory synapses. Journal of Integrative Neuroscience. 4: 445-64. PMID 16385640 DOI: 10.1142/S0219635205000987  0.116
2022 Lillo A, Marin S, Serrano-Marín J, Bernal-Casas D, Binetti N, Navarro G, Cascante M, Sánchez-Navés J, Franco R. Biogenic Amine Levels Markedly Increase in the Aqueous Humor of Individuals with Controlled Type 2 Diabetes. International Journal of Molecular Sciences. 23. PMID 36361545 DOI: 10.3390/ijms232112752  0.116
2012 Franco R, Canela EI, Casado V, Ferre S. Platforms for the identification of GPCR targets, and of orthosteric and allosteric modulators. Expert Opinion On Drug Discovery. 5: 391-403. PMID 22823089 DOI: 10.1517/17460441003653163  0.115
2002 Ginés S, Mariño M, Mallol J, Canela EI, Morimoto C, Callebaut C, Hovanessian A, Casadó V, Lluis C, Franco R. Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction. The Biochemical Journal. 361: 203-9. PMID 11772392 DOI: 10.1042/0264-6021:3610203  0.112
2015 Ugarte A, Gil-Bea F, García-Barroso C, Cedazo-Minguez Á, Ramírez MJ, Franco R, García-Osta A, Oyarzabal J, Cuadrado-Tejedor M. Decreased levels of guanosine 3', 5'-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease. Neuropathology and Applied Neurobiology. 41: 471-82. PMID 25488891 DOI: 10.1111/nan.12203  0.111
2018 Franco R, Sánchez-Arias JA, Navarro G, Lanciego JL. Glucocerebrosidase Mutations and Synucleinopathies. Potential Role of Sterylglucosides and Relevance of Studying Both GBA1 and GBA2 Genes. Frontiers in Neuroanatomy. 12: 52. PMID 30002620 DOI: 10.3389/fnana.2018.00052  0.107
2014 García-Barroso C, Ugarte A, Martínez M, Rico AJ, Lanciego JL, Franco R, Oyarzabal J, Cuadrado-Tejedor M, García-Osta A. Phosphodiesterase inhibition in cognitive decline. Journal of Alzheimer's Disease : Jad. 42: S561-73. PMID 25125473 DOI: 10.3233/JAD-141341  0.106
2009 Giraldo P, Alfonso P, Atutxa K, Fernández-Galán MA, Barez A, Franco R, Alonso D, Martin A, Latre P, Pocovi M. Real-world clinical experience with long-term miglustat maintenance therapy in type 1 Gaucher disease: the ZAGAL project. Haematologica. 94: 1771-5. PMID 19608672 DOI: 10.3324/haematol.2009.008078  0.098
2016 Oliva H, Pacheco R, Martinez-Navio JM, Rodríguez-García M, Naranjo-Gómez M, Climent N, Prado C, Gil C, Plana M, García F, Miró JM, Franco R, Borras FE, Navaratnam N, Gatell JM, et al. Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4(+) T-cell activation and dendritic cell maturation. Immunology and Cell Biology. PMID 26987686 DOI: 10.1038/icb.2016.28  0.093
2013 Cuadrado-Tejedor M, Oyarzabal J, Lucas MP, Franco R, García-Osta A. Epigenetic drugs in Alzheimer's disease. Biomolecular Concepts. 4: 433-45. PMID 25436752 DOI: 10.1515/bmc-2013-0012  0.092
2013 García-Barroso C, Ricobaraza A, Pascual-Lucas M, Unceta N, Rico AJ, Goicolea MA, Sallés J, Lanciego JL, Oyarzabal J, Franco R, Cuadrado-Tejedor M, García-Osta A. Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD. Neuropharmacology. 64: 114-23. PMID 22776546 DOI: 10.1016/j.neuropharm.2012.06.052  0.091
2016 Giraldo P, Andrade-Campos M, Alfonso P, Irun P, Atutxa K, Acedo A, Barez A, Blanes M, Diaz-Morant V, Fernández-Galán MA, Franco R, Gil-Cortes C, Giner V, Ibañez A, Latre P, et al. Twelve years of experience with miglustat in the treatment of type 1 Gaucher disease: The Spanish ZAGAL project. Blood Cells, Molecules & Diseases. PMID 27836529 DOI: 10.1016/j.bcmd.2016.10.017  0.089
2017 Andrade-Campos M, Alfonso P, Irun P, Armstrong J, Calvo C, Dalmau J, Domingo MR, Barbera JL, Cano H, Fernandez-Galán MA, Franco R, Gracia I, Gracia-Antequera M, Ibañez A, Lendinez F, et al. Diagnosis features of pediatric Gaucher disease patients in the era of enzymatic therapy, a national-base study from the Spanish Registry of Gaucher Disease. Orphanet Journal of Rare Diseases. 12: 84. PMID 28468677 DOI: 10.1186/s13023-017-0627-z  0.088
2007 Capablo JL, Franco R, De Cabezón AS, Alfonso P, Pocovi M, Giraldo P. Neurologic improvement in a type 3 Gaucher disease patient treated with imiglucerase/miglustat combination Epilepsia. 48: 1406-1408. PMID 17433057 DOI: 10.1111/j.1528-1167.2007.01074.x  0.087
2021 Miralpeix C, Reguera AC, Fosch A, Casas M, Lillo J, Navarro G, Franco R, Casas J, Alexander SPH, Casals N, Rodríguez-Rodríguez R. CPT1C negatively regulates the endocannabinoid hydrolase ABHD6 depending on nutritional status. British Journal of Pharmacology. PMID 33444462 DOI: 10.1111/bph.15377  0.086
2018 Zamarbide M, Gil-Bea FJ, Bannenberg P, Martínez-Pinilla E, Sandoval J, Franco R, Pérez-Mediavilla A. Maternal imprinting on cognition markers of wild type and transgenic Alzheimer's disease model mice. Scientific Reports. 8: 6434. PMID 29691440 DOI: 10.1038/S41598-018-24710-7  0.086
2012 Cuadrado-Tejedor M, Ricobaraza A, Frechilla D, Franco R, Pérez-Mediavilla A, Garcia-Osta A. Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice. Journal of Alzheimer's Disease : Jad. 28: 567-78. PMID 22045482 DOI: 10.3233/JAD-2011-110572  0.084
2011 Cuadrado-Tejedor M, Ricobaraza A, Del Río J, Frechilla D, Franco R, Pérez-Mediavilla A, Garcia-Osta A. Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation. Behavioural Brain Research. 220: 338-43. PMID 21238494 DOI: 10.1016/j.bbr.2011.01.005  0.07
2014 Gaja V, Gómez-Vallejo V, Puigivila M, Pérez-Campaña C, Martin A, García-Osta A, Calvo-Fernández T, Cuadrado-Tejedor M, Franco R, Llop J. Synthesis and evaluation of (13)N-labelled azo compounds for β-amyloid imaging in mice. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 16: 538-49. PMID 24310721 DOI: 10.1007/s11307-013-0708-x  0.068
2015 Nakamura RE, Vincent JL, Fukushima JT, Almeida JP, Franco RA, Lee Park C, Osawa EA, Pinto Silva CM, Costa Auler JO, Landoni G, Barbosa Gomes Galas FR, Filho RK, Hajjar LA. A liberal strategy of red blood cell transfusion reduces cardiogenic shock in elderly patients undergoing cardiac surgery. The Journal of Thoracic and Cardiovascular Surgery. 150: 1314-20. PMID 26318355 DOI: 10.1016/j.jtcvs.2015.07.051  0.066
2015 Osawa EA, Rhodes A, Landoni G, Galas FR, Fukushima JT, Park CH, Almeida JP, Nakamura RE, Strabelli TM, Pileggi B, Leme AC, Fominskiy E, Sakr Y, Lima M, Franco RA, et al. Effect of Perioperative Goal-Directed Hemodynamic Resuscitation Therapy on Outcomes Following Cardiac Surgery: A Randomized Clinical Trial and Systematic Review. Critical Care Medicine. PMID 26646462 DOI: 10.1097/CCM.0000000000001479  0.062
2017 Bergamin FS, Almeida JP, Landoni G, Galas FR, Fukushima JT, Fominskiy E, Park CH, Osawa EA, Diz MP, Oliveira GQ, Franco RA, Nakamura RE, Almeida EM, Abdala E, Freire MP, et al. Liberal Versus Restrictive Transfusion Strategy in Critically Ill Oncologic Patients: The Transfusion Requirements in Critically Ill Oncologic Patients Randomized Controlled Trial. Critical Care Medicine. PMID 28240687 DOI: 10.1097/CCM.0000000000002283  0.062
2016 Hajjar LA, Vincent JL, Gomes Galas FR, Rhodes A, Landoni G, Osawa EA, Melo RR, Sundin MR, Grande SM, Gaiotto FA, Pomerantzeff PM, Dallan LO, Franco RA, Nakamura RE, Lisboa LA, et al. Vasopressin versus Norepinephrine in Patients with Vasoplegic Shock After Cardiac Surgery: The VANCS Randomized Controlled Trial. Anesthesiology. PMID 27841822 DOI: 10.1097/ALN.0000000000001434  0.059
2019 Rodrigues C, Siciliano RF, Filho HC, Charbel CE, de Carvalho Sarahyba da Silva L, Baiardo Redaelli M, de Paula Rosa Passetti AP, Franco MRG, Rossi F, Zeigler R, De Backer D, Franco RA, de Almeida JP, Rizk SI, Fukushima JT, et al. The effect of a rapid molecular blood test on the use of antibiotics for nosocomial sepsis: a randomized clinical trial. Journal of Intensive Care. 7: 37. PMID 31367384 DOI: 10.1186/s40560-019-0391-3  0.059
2018 Gerent ARM, Almeida JP, Fominskiy E, Landoni G, de Oliveira GQ, Rizk SI, Fukushima JT, Simoes CM, Ribeiro U, Park CL, Nakamura RE, Franco RA, Cândido PI, Tavares CR, Camara L, et al. Effect of postoperative goal-directed therapy in cancer patients undergoing high-risk surgery: a randomized clinical trial and meta-analysis. Critical Care (London, England). 22: 133. PMID 29792232 DOI: 10.1186/s13054-018-2055-4  0.058
2018 Rocha Ferreira GS, de Almeida JP, Landoni G, Vincent JL, Fominskiy E, Gomes Galas FRB, Gaiotto FA, Dallan LO, Franco RA, Lisboa LA, Palma Dallan LR, Fukushima JT, Rizk SI, Park CL, Strabelli TM, et al. Effect of a Perioperative Intra-Aortic Balloon Pump in High-Risk Cardiac Surgery Patients: A Randomized Clinical Trial. Critical Care Medicine. PMID 29727370 DOI: 10.1097/CCM.0000000000003185  0.058
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