| Year |
Citation |
Score |
| 2024 |
Georgiev P, Han S, Huang AY, Nguyen TH, Drijvers JM, Creasey H, Pereira JA, Yao CH, Park JS, Conway TS, Fung ME, Liang D, Peluso M, Joshi S, Rowe JH, ... ... Sharpe AH, et al. Age-associated contraction of tumor-specific T cells impairs antitumor immunity. Cancer Immunology Research. PMID 39186561 DOI: 10.1158/2326-6066.CIR-24-0463 |
0.342 |
|
| 2024 |
Andrews LP, Butler SC, Cui J, Cillo AR, Cardello C, Liu C, Brunazzi EA, Baessler A, Xie B, Kunning SR, Ngiow SF, Huang YJ, Manne S, Sharpe AH, Delgoffe GM, et al. LAG-3 and PD-1 synergize on CD8 T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity. Cell. 187: 4355-4372.e22. PMID 39121848 DOI: 10.1016/j.cell.2024.07.016 |
0.462 |
|
| 2024 |
Ngiow SF, Manne S, Huang YJ, Azar T, Chen Z, Mathew D, Chen Q, Khan O, Wu JE, Alcalde V, Flowers AJ, McClain S, Baxter AE, Kurachi M, Shi J, ... ... Sharpe AH, et al. LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity. Cell. 187: 4336-4354.e19. PMID 39121847 DOI: 10.1016/j.cell.2024.07.018 |
0.48 |
|
| 2024 |
Milling LE, Markson SC, Tjokrosurjo Q, Derosia NM, Streeter ISL, Hickok GH, Lemmen AM, Nguyen TH, Prathima P, Fithian W, Schwartz MA, Hacohen N, Doench JG, LaFleur MW, Sharpe AH. Framework for in vivo T cell screens. The Journal of Experimental Medicine. 221. PMID 38411617 DOI: 10.1084/jem.20230699 |
0.306 |
|
| 2024 |
Burke KP, Chaudhri A, Freeman GJ, Sharpe AH. The B7:CD28 family and friends: Unraveling coinhibitory interactions. Immunity. 57: 223-244. PMID 38354702 DOI: 10.1016/j.immuni.2024.01.013 |
0.368 |
|
| 2024 |
Cohen JN, Gouirand V, Macon CE, Lowe MM, Boothby IC, Moreau JM, Gratz IK, Stoecklinger A, Weaver CT, Sharpe AH, Ricardo-Gonzalez RR, Rosenblum MD. Regulatory T cells in skin mediate immune privilege of the hair follicle stem cell niche. Science Immunology. 9: eadh0152. PMID 38181095 DOI: 10.1126/sciimmunol.adh0152 |
0.345 |
|
| 2023 |
Denize T, Jegede OA, Matar S, El Ahmar N, West DJ, Walton E, Bagheri AS, Savla V, Nabil Laimon Y, Gupta S, Vemula SV, Braun DA, Burke KP, Catalano PJ, Freeman GJ, ... ... Sharpe AH, et al. PD-1 Expression on Intratumoral Regulatory T Cells is Associated with Lack of Benefit from Anti-PD-1 Therapy in Metastatic Clear Cell Renal Cell Carcinoma Patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 38060202 DOI: 10.1158/1078-0432.CCR-23-2274 |
0.367 |
|
| 2023 |
Georgiev P, Benamar M, Han S, Haigis MC, Sharpe AH, Chatila TA. Regulatory T cells in dominant immunologic tolerance. The Journal of Allergy and Clinical Immunology. PMID 37778472 DOI: 10.1016/j.jaci.2023.09.025 |
0.374 |
|
| 2023 |
Rowe JH, Elia I, Shahid O, Gaudiano EF, Sifnugel NE, Johnson S, Reynolds AG, Fung ME, Joshi S, LaFleur MW, Park JS, Pauken KE, Rabinowitz JD, Freeman GJ, Haigis MC, ... Sharpe AH, et al. Formate supplementation enhances anti-tumor CD8+ T cell fitness and efficacy of PD-1 blockade. Cancer Discovery. PMID 37728660 DOI: 10.1158/2159-8290.CD-22-1301 |
0.425 |
|
| 2023 |
Kurmi K, Liang D, van de Ven R, Georgiev P, Gassaway BM, Han S, Notarangelo G, Harris IS, Yao CH, Park JS, Hu SH, Peng J, Drijvers JM, Boswell S, Sokolov A, ... ... Sharpe AH, et al. Metabolic modulation of mitochondrial mass during CD4 T cell activation. Cell Chemical Biology. PMID 37716347 DOI: 10.1016/j.chembiol.2023.08.008 |
0.362 |
|
| 2023 |
Collier JL, Pauken KE, Lee CAA, Patterson DG, Markson SC, Conway TS, Fung ME, France JA, Mucciarone KN, Lian CG, Murphy GF, Sharpe AH. Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice. The Journal of Experimental Medicine. 220. PMID 37432393 DOI: 10.1084/jem.20221920 |
0.444 |
|
| 2023 |
Bod L, Kye YC, Shi J, Torlai Triglia E, Schnell A, Fessler J, Ostrowski SM, Von-Franque MY, Kuchroo JR, Barilla RM, Zaghouani S, Christian E, Delorey TM, Mohib K, Xiao S, ... ... Sharpe AH, et al. B-cell-specific checkpoint molecules that regulate anti-tumour immunity. Nature. PMID 37344597 DOI: 10.1038/s41586-023-06231-0 |
0.4 |
|
| 2023 |
Burke KP, Markson SC, Sharpe AH. Tracking tumor-specific CD8 T cell responses. Trends in Immunology. PMID 37031062 DOI: 10.1016/j.it.2023.03.012 |
0.422 |
|
| 2023 |
Datta M, Chatterjee S, Perez EM, Gritsch S, Roberge S, Duquette M, Chen IX, Naxerova K, Kumar AS, Ghosh M, Emblem KE, Ng MR, Ho WW, Kumar P, Krishnan S, ... ... Sharpe AH, et al. Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models. Proceedings of the National Academy of Sciences of the United States of America. 120: e2219199120. PMID 36724255 DOI: 10.1073/pnas.2219199120 |
0.316 |
|
| 2022 |
Han S, Georgiev P, Ringel AE, Sharpe AH, Haigis MC. Age-associated remodeling of T cell immunity and metabolism. Cell Metabolism. PMID 36473467 DOI: 10.1016/j.cmet.2022.11.005 |
0.311 |
|
| 2022 |
Notarangelo G, Spinelli JB, Perez EM, Baker GJ, Kurmi K, Elia I, Stopka SA, Baquer G, Lin JR, Golby AJ, Joshi S, Baron HF, Drijvers JM, Georgiev P, Ringel AE, ... ... Sharpe AH, et al. Oncometabolite d-2HG alters T cell metabolism to impair CD8 T cell function. Science (New York, N.Y.). 377: 1519-1529. PMID 36173860 DOI: 10.1126/science.abj5104 |
0.306 |
|
| 2022 |
Hashimoto M, Araki K, Cardenas MA, Li P, Jadhav RR, Kissick HT, Hudson WH, McGuire DJ, Obeng RC, Wieland A, Lee J, McManus DT, Ross JL, Im SJ, Lee J, ... ... Sharpe AH, et al. PD-1 combination therapy with IL-2 modifies CD8 T cell exhaustion program. Nature. PMID 36171288 DOI: 10.1038/s41586-022-05257-0 |
0.361 |
|
| 2022 |
Hurrell BP, Helou DG, Howard E, Painter JD, Shafiei-Jahani P, Sharpe AH, Akbari O. PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability. Nature Communications. 13: 5118. PMID 36045140 DOI: 10.1038/s41467-022-32899-5 |
0.332 |
|
| 2022 |
Helou DG, Quach C, Fung M, Painter JD, Hurrell BP, Eddie Loh YH, Howard E, Shafiei-Jahani P, Soroosh P, Sharpe AH, Akbari O. Human PD-1 agonist treatment alleviates neutrophilic asthma by reprogramming T cells. The Journal of Allergy and Clinical Immunology. PMID 35963455 DOI: 10.1016/j.jaci.2022.07.022 |
0.314 |
|
| 2022 |
Elia I, Rowe JH, Johnson S, Joshi S, Notarangelo G, Kurmi K, Weiss S, Freeman GJ, Sharpe AH, Haigis MC. Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8 T cells. Cell Metabolism. PMID 35820416 DOI: 10.1016/j.cmet.2022.06.008 |
0.371 |
|
| 2022 |
Alvarez-Breckenridge C, Markson SC, Stocking JH, Nayyar N, Lastrapes M, Strickland MR, Kim AE, de Sauvage M, Dahal A, Larson JM, Mora JL, Navia AW, Klein RH, Kuter BM, Gill CM, ... ... Sharpe AH, et al. Microenvironmental landscape of human melanoma brain metastases in response to immune checkpoint inhibition. Cancer Immunology Research. PMID 35706413 DOI: 10.1158/2326-6066.CIR-21-0870 |
0.347 |
|
| 2022 |
Perry JA, Shallberg L, Clark JT, Gullicksrud JA, DeLong JH, Douglas BB, Hart AP, Lanzar Z, O'Dea K, Konradt C, Park J, Kuchroo JR, Grubaugh D, Zaretsky AG, Brodsky IE, ... ... Sharpe AH, et al. PD-L1-PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection. Nature Immunology. PMID 35437326 DOI: 10.1038/s41590-022-01170-w |
0.427 |
|
| 2022 |
Hasim MS, Marotel M, Hodgins JJ, Vulpis E, Makinson OJ, Asif S, Shih HY, Scheer AK, MacMillan O, Alonso FG, Burke KP, Cook DP, Li R, Petrucci MT, Santoni A, ... ... Sharpe AH, et al. When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer. Science Advances. 8: eabj3286. PMID 35417234 DOI: 10.1126/sciadv.abj3286 |
0.404 |
|
| 2022 |
Zaiken MC, Flynn R, Paz KG, Rhee SY, Jin S, Mohamed FA, Saha A, Thangavelu G, Park PMC, Hemming ML, Sage PT, Sharpe AH, DuPage M, Bluestone JA, Panoskaltsis-Mortari A, et al. BET-bromodomain and EZH2 inhibitor treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes. Blood. PMID 35226736 DOI: 10.1182/blood.2021014557 |
0.628 |
|
| 2022 |
Lagattuta KA, Kang JB, Nathan A, Pauken KE, Jonsson AH, Rao DA, Sharpe AH, Ishigaki K, Raychaudhuri S. Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate. Nature Immunology. PMID 35177831 DOI: 10.1038/s41590-022-01129-x |
0.342 |
|
| 2022 |
Pauken KE, Lagattuta KA, Lu BY, Lucca LE, Daud AI, Hafler DA, Kluger HM, Raychaudhuri S, Sharpe AH. TCR-sequencing in cancer and autoimmunity: barcodes and beyond. Trends in Immunology. PMID 35090787 DOI: 10.1016/j.it.2022.01.002 |
0.392 |
|
| 2021 |
Borges TJ, Murakami N, Lape IT, Gassen RB, Liu K, Cai S, Daccache J, Safa K, Shimizu T, Ohori S, Paterson AM, Cravedi P, Azzi J, Sage P, Sharpe A, et al. Overexpression of PD-1 on T cells promotes tolerance in cardiac transplantation via an ICOS-dependent mechanism. Jci Insight. PMID 34752418 DOI: 10.1172/jci.insight.142909 |
0.684 |
|
| 2021 |
Andrews LP, Vignali KM, Szymczak-Workman AL, Burton AR, Brunazzi EA, Ngiow SF, Harusato A, Sharpe AH, Wherry EJ, Taniuchi I, Workman CJ, Vignali DAA. A Cre-driven allele-conditioning line to interrogate CD4 conventional T cells. Immunity. PMID 34551314 DOI: 10.1016/j.immuni.2021.08.029 |
0.41 |
|
| 2021 |
Howard E, Hurrell BP, Helou DG, Quach C, Painter JD, Shafiei-Jahani P, Fung M, Gill PS, Soroosh P, Sharpe AH, Akbari O. PD-1 Blockade on Tumor Microenvironment-Resident ILC2s Promotes TNF-α Production and Restricts Progression of Metastatic Melanoma. Frontiers in Immunology. 12: 733136. PMID 34531874 DOI: 10.3389/fimmu.2021.733136 |
0.302 |
|
| 2021 |
Collier JL, Weiss SA, Pauken KE, Sen DR, Sharpe AH. Not-so-opposite ends of the spectrum: CD8 T cell dysfunction across chronic infection, cancer and autoimmunity. Nature Immunology. PMID 34140679 DOI: 10.1038/s41590-021-00949-7 |
0.382 |
|
| 2021 |
Pauken KE, Torchia JA, Chaudhri A, Sharpe AH, Freeman GJ. Emerging concepts in PD-1 checkpoint biology. Seminars in Immunology. 101480. PMID 34006473 DOI: 10.1016/j.smim.2021.101480 |
0.346 |
|
| 2021 |
Braun DA, Street K, Burke KP, Cookmeyer DL, Denize T, Pedersen CB, Gohil SH, Schindler N, Pomerance L, Hirsch L, Bakouny Z, Hou Y, Forman J, Huang T, Li S, ... ... Sharpe AH, et al. Progressive immune dysfunction with advancing disease stage in renal cell carcinoma. Cancer Cell. PMID 33711273 DOI: 10.1016/j.ccell.2021.02.013 |
0.365 |
|
| 2021 |
Pauken KE, Shahid O, Lagattuta KA, Mahuron KM, Luber JM, Lowe MM, Huang L, Delaney C, Long JM, Fung ME, Newcomer K, Tsai KK, Chow M, Guinn S, Kuchroo JR, ... ... Sharpe AH, et al. Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment. The Journal of Experimental Medicine. 218. PMID 33651880 DOI: 10.1084/jem.20200920 |
0.405 |
|
| 2021 |
Lo JA, Kawakubo M, Juneja VR, Su MY, Erlich TH, LaFleur MW, Kemeny LV, Rashid M, Malehmir M, Rabi SA, Raghavan R, Allouche J, Kasumova G, Frederick DT, Pauken KE, ... ... Sharpe AH, et al. Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses. Science Translational Medicine. 13. PMID 33597266 DOI: 10.1126/scitranslmed.abd8636 |
0.343 |
|
| 2021 |
Johnnidis JB, Muroyama Y, Ngiow SF, Chen Z, Manne S, Cai Z, Song S, Platt JM, Schenkel JM, Abdel-Hakeem M, Beltra JC, Greenplate AR, Ali MA, Nzingha K, Giles JR, ... ... Sharpe AH, et al. Inhibitory signaling sustains a distinct early memory CD8 T cell precursor that is resistant to DNA damage. Science Immunology. 6. PMID 33452106 DOI: 10.1126/sciimmunol.abe3702 |
0.387 |
|
| 2021 |
Tan CL, Kuchroo JR, Sage PT, Liang D, Francisco LM, Buck J, Thaker YR, Zhang Q, McArdel SL, Juneja VR, Lee SJ, Lovitch SB, Lian C, Murphy GF, Blazar BR, ... ... Sharpe AH, et al. PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance. The Journal of Experimental Medicine. 218. PMID 33045061 DOI: 10.1084/jem.20182232 |
0.73 |
|
| 2020 |
Ringel AE, Drijvers JM, Baker GJ, Catozzi A, García-Cañaveras JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S, Yao CH, Yoon H, Sage PT, LaFleur MW, Trombley JD, ... ... Sharpe AH, et al. Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity. Cell. PMID 33301708 DOI: 10.1016/j.cell.2020.11.009 |
0.651 |
|
| 2020 |
Drijvers JM, Gillis JE, Muijlwijk T, Nguyen TH, Gaudiano EF, Harris IS, LaFleur MW, Ringel AE, Yao CH, Kurmi K, Juneja VR, Trombley JD, Haigis M, Sharpe AH. Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells. Cancer Immunology Research. PMID 33277233 DOI: 10.1158/2326-6066.CIR-20-0384 |
0.401 |
|
| 2020 |
Ficial M, Jegede OA, Sant'Angelo M, Hou Y, Flaifel A, Pignon JC, Braun DA, Wind-Rotolo M, Sticco-Ivins M, Catalano PJ, Freeman GJ, Sharpe AH, Hodi FS, Motzer RJ, Wu CJ, et al. Expression of T-cell Exhaustion Molecules and Human Endogenous Retroviruses as Predictive Biomarkers for response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 33219016 DOI: 10.1158/1078-0432.CCR-20-3084 |
0.344 |
|
| 2020 |
Sage PT, Sharpe AH. The multifaceted functions of follicular regulatory T cells. Current Opinion in Immunology. 67: 68-74. PMID 33176227 DOI: 10.1016/j.coi.2020.10.009 |
0.708 |
|
| 2020 |
Sungnak W, Wagner A, Kowalczyk MS, Bod L, Kye YC, Sage PT, Sharpe AH, Sobel RA, Quintana FJ, Rozenblatt-Rosen O, Regev A, Wang C, Yosef N, Kuchroo VK. T Follicular Regulatory Cell-Derived Fibrinogen-like Protein 2 Regulates Production of Autoantibodies and Induction of Systemic Autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). PMID 33168576 DOI: 10.4049/jimmunol.2000748 |
0.736 |
|
| 2020 |
Chen IX, Newcomer K, Pauken KE, Juneja VR, Naxerova K, Wu MW, Pinter M, Sen DR, Singer M, Sharpe AH, Jain RK. A bilateral tumor model identifies transcriptional programs associated with patient response to immune checkpoint blockade. Proceedings of the National Academy of Sciences of the United States of America. PMID 32907939 DOI: 10.1073/Pnas.2002806117 |
0.432 |
|
| 2020 |
Helou DG, Shafiei-Jahani P, Lo R, Howard E, Hurrell BP, Galle-Treger L, Painter JD, Lewis G, Soroosh P, Sharpe AH, Akbari O. PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity. Nature Communications. 11: 3998. PMID 32778730 DOI: 10.1038/S41467-020-17813-1 |
0.405 |
|
| 2020 |
Pauken KE, Godec J, Odorizzi PM, Brown KE, Yates KB, Ngiow SF, Burke KP, Maleri S, Grande SM, Francisco LM, Ali MA, Imam S, Freeman GJ, Haining WN, Wherry EJ, ... Sharpe AH, et al. The PD-1 Pathway Regulates Development and Function of Memory CD8 T Cells following Respiratory Viral Infection. Cell Reports. 31: 107827. PMID 32610128 DOI: 10.1016/J.Celrep.2020.107827 |
0.66 |
|
| 2020 |
Braun DA, Hou Y, Bakouny Z, Ficial M, Sant' Angelo M, Forman J, Ross-Macdonald P, Berger AC, Jegede OA, Elagina L, Steinharter J, Sun M, Wind-Rotolo M, Pignon JC, Cherniack AD, ... ... Sharpe AH, et al. Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma. Nature Medicine. PMID 32472114 DOI: 10.1038/S41591-020-0839-Y |
0.456 |
|
| 2020 |
LaFleur MW, Miller BC, Sharpe AH. Prevention of CAR-T-cell dysfunction. Nature Biomedical Engineering. PMID 31911621 DOI: 10.1038/S41551-019-0512-2 |
0.456 |
|
| 2020 |
Ficial M, Jegede O, Sant'Angelo M, Moreno S, Braun DA, Wind-Rotolo M, Pignon J, Catalano PJ, Sun M, Van Allen EM, Freeman GJ, Sharpe A, Hodi FS, Motzer RJ, Wu CJ, et al. Evaluation of predictive biomarkers for nivolumab in patients (pts) with metastatic clear cell renal cell carcinoma (mccRCC) from the CheckMate-025 (CM-025) trial. Journal of Clinical Oncology. 38: 5023-5023. DOI: 10.1200/Jco.2020.38.15_Suppl.5023 |
0.382 |
|
| 2020 |
Braun DA, Hou Y, Bakouny Z, Ficial M, Sant'Angelo M, Ross-Macdonald P, Jegede O, Sun M, Wind-Rotolo M, Pignon J, Neuberg DS, Catalano PJ, Freeman GJ, Sharpe A, McDermott DF, et al. Immunogenomic characterization of advanced clear cell renal cell carcinoma treated with PD-1 blockade. Journal of Clinical Oncology. 38: 5010-5010. DOI: 10.1200/Jco.2020.38.15_Suppl.5010 |
0.44 |
|
| 2019 |
Brown FD, Sen DR, LaFleur MW, Godec J, Lukacs-Kornek V, Schildberg FA, Kim HJ, Yates KB, Ricoult SJH, Bi K, Trombley JD, Kapoor VN, Stanley IA, Cremasco V, Danial NN, ... ... Sharpe AH, et al. Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling. Nature Immunology. PMID 31636464 DOI: 10.1038/S41590-019-0515-X |
0.52 |
|
| 2019 |
Miller BC, Sen DR, Al Abosy R, Bi K, Virkud YV, LaFleur MW, Yates KB, Lako A, Felt K, Naik GS, Manos M, Gjini E, Kuchroo JR, Ishizuka JJ, Collier JL, ... ... Sharpe AH, et al. Author Correction: Subsets of exhausted CD8 T cells differentially mediate tumor control and respond to checkpoint blockade. Nature Immunology. PMID 31582823 DOI: 10.1038/S41590-019-0528-5 |
0.434 |
|
| 2019 |
Blank CU, Haining WN, Held W, Hogan PG, Kallies A, Lugli E, Lynn RC, Philip M, Rao A, Restifo NP, Schietinger A, Schumacher TN, Schwartzberg PL, Sharpe AH, Speiser DE, et al. Defining 'T cell exhaustion'. Nature Reviews. Immunology. PMID 31570879 DOI: 10.1038/S41577-019-0221-9 |
0.487 |
|
| 2019 |
Ron-Harel N, Ghergurovich JM, Notarangelo G, LaFleur MW, Tsubosaka Y, Sharpe AH, Rabinowitz JD, Haigis MC. T Cell Activation Depends on Extracellular Alanine. Cell Reports. 28: 3011-3021.e4. PMID 31533027 DOI: 10.1016/J.Celrep.2019.08.034 |
0.453 |
|
| 2019 |
LaFleur MW, Nguyen TH, Coxe MA, Miller BC, Yates KB, Gillis JE, Sen DR, Gaudiano EF, Al Abosy R, Freeman GJ, Haining WN, Sharpe AH. PTPN2 regulates the generation of exhausted CD8 T cell subpopulations and restrains tumor immunity. Nature Immunology. PMID 31527834 DOI: 10.1038/S41590-019-0480-4 |
0.508 |
|
| 2019 |
Clement RL, Daccache J, Mohammed MT, Diallo A, Blazar BR, Kuchroo VK, Lovitch SB, Sharpe AH, Sage PT. Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses. Nature Immunology. PMID 31477921 DOI: 10.1038/S41590-019-0472-4 |
0.744 |
|
| 2019 |
Rashidian M, LaFleur MW, Verschoor VL, Dongre A, Zhang Y, Nguyen TH, Kolifrath S, Aref AR, Lau CJ, Paweletz CP, Bu X, Freeman GJ, Barrasa MI, Weinberg RA, Sharpe AH, et al. Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade. Proceedings of the National Academy of Sciences of the United States of America. PMID 31375632 DOI: 10.1073/Pnas.1905005116 |
0.485 |
|
| 2019 |
Pauken KE, Dougan M, Rose NR, Lichtman AH, Sharpe AH. Adverse Events Following Cancer Immunotherapy: Obstacles and Opportunities. Trends in Immunology. PMID 31053497 DOI: 10.1016/J.It.2019.04.002 |
0.401 |
|
| 2019 |
LaFleur MW, Nguyen TH, Coxe MA, Yates KB, Trombley JD, Weiss SA, Brown FD, Gillis JE, Coxe DJ, Doench JG, Haining WN, Sharpe AH. A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system. Nature Communications. 10: 1668. PMID 30971695 DOI: 10.1038/S41467-019-09656-2 |
0.397 |
|
| 2019 |
Miller BC, Sen DR, Al Abosy R, Bi K, Virkud YV, LaFleur MW, Yates KB, Lako A, Felt K, Naik GS, Manos M, Gjini E, Kuchroo JR, Ishizuka JJ, Collier JL, ... ... Sharpe AH, et al. Subsets of exhausted CD8 T cells differentially mediate tumor control and respond to checkpoint blockade. Nature Immunology. 20: 326-336. PMID 30778252 DOI: 10.1038/S41590-019-0312-6 |
0.538 |
|
| 2019 |
Galle-Treger L, Sankaranarayanan I, Hurrell BP, Howard E, Lo R, Maazi H, Lewis G, Banie H, Epstein AL, Hu P, Rehan VK, Gilliland FD, Allayee H, Soroosh P, Sharpe AH, et al. Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes. Nature Communications. 10: 713. PMID 30755607 DOI: 10.1038/S41467-019-08449-X |
0.317 |
|
| 2019 |
Paz K, Flynn R, Du J, Tannheimer S, Johnson AJ, Dong S, Stark AK, Okkenhaug K, Panoskaltsis-Mortari A, Sage PT, Sharpe AH, Luznik L, Ritz J, Soiffer RJ, Cutler CS, et al. Targeting PI3Kδ Function For Amelioration of Murine Chronic Graft-Versus-Host Disease. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 30748099 DOI: 10.1111/Ajt.15305 |
0.719 |
|
| 2019 |
Hou S, Clement RL, Diallo A, Blazar BR, Rudensky AY, Sharpe AH, Sage PT. FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program. The Journal of Experimental Medicine. PMID 30705058 DOI: 10.1084/Jem.20181134 |
0.681 |
|
| 2019 |
Sen DR, Miller BC, Abosy RA, Bi K, LaFleur MW, Yates KB, Lako A, Felt KD, Naik GS, Manos M, Gjini E, Virkud YV, Hodi S, Rodig SJ, Sharpe AH, et al. Abstract A216: Functionally specialized subsets of exhausted CD8+ T-cells mediate tumor control and response to checkpoint blockade Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A216 |
0.522 |
|
| 2019 |
Miller BC, Sen DR, Abosy RA, Bi K, Virkud YV, LaFleur MW, Yates KB, Lako A, Felt K, Naik GS, Manos M, Gjini E, Hodi FS, Rodig SJ, Sharpe AH, et al. Abstract 2701: Functionally specialized subsets of exhausted CD8+ T cells mediate tumor control and differentially respond to checkpoint blockade Cancer Research. 79: 2701-2701. DOI: 10.1158/1538-7445.Am2019-2701 |
0.533 |
|
| 2019 |
LaFleur M, Sharpe A, Nguyen T, Coxe MC, Haining WN. Creating CRISPR-Cas9 Knockout Immune Cells using CHIME Protocol Exchange. DOI: 10.1038/Protex.2019.034 |
0.388 |
|
| 2018 |
Tan CL, Peluso MJ, Drijvers JM, Mera CM, Grande SM, Brown KE, Godec J, Freeman GJ, Sharpe AH. CD160 Stimulates CD8 T Cell Responses and Is Required for Optimal Protective Immunity to . Immunohorizons. 2: 238-250. PMID 31022694 DOI: 10.4049/immunohorizons.1800039 |
0.594 |
|
| 2018 |
Ron-Harel N, Notarangelo G, Ghergurovich JM, Paulo JA, Sage PT, Santos D, Satterstrom FK, Gygi SP, Rabinowitz JD, Sharpe AH, Haigis MC. Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proceedings of the National Academy of Sciences of the United States of America. 115: 13347-13352. PMID 30530686 DOI: 10.1073/Pnas.1804149115 |
0.706 |
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| 2018 |
Paz K, Flynn R, Du J, Qi J, Luznik L, Maillard I, MacDonald KP, Hill GR, Serody JS, Murphy WJ, Sage PT, Sharpe AH, Miklos D, Culter CS, Koreth J, et al. Small-molecule BCL6 inhibitor effectively treats mice with non-sclerodermatous chronic graft-versus-host disease. Blood. PMID 30279226 DOI: 10.1182/Blood-2018-03-839993 |
0.702 |
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| 2018 |
Sheng W, LaFleur MW, Nguyen TH, Chen S, Chakravarthy A, Conway JR, Li Y, Chen H, Yang H, Hsu PH, Van Allen EM, Freeman GJ, De Carvalho DD, He HH, Sharpe AH, et al. LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade. Cell. PMID 29937226 DOI: 10.1016/J.Cell.2018.05.052 |
0.454 |
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| 2018 |
Mooradian MJ, Reuben A, Prieto PA, Hazar-Rethinam M, Frederick DT, Nadres B, Piris A, Juneja V, Cooper ZA, Sharpe AH, Corcoran RB, Flaherty KT, Lawrence DP, Wargo JA, Sullivan RJ. A phase II study of combined therapy with a BRAF inhibitor (vemurafenib) and interleukin-2 (aldesleukin) in patients with metastatic melanoma. Oncoimmunology. 7: e1423172. PMID 29721378 DOI: 10.1080/2162402X.2017.1423172 |
0.336 |
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| 2018 |
Yim SH, Everley RA, Schildberg FA, Lee SG, Orsi A, Barbati ZR, Karatepe K, Fomenko DE, Tsuji PA, Luo HR, Gygi SP, Sitia R, Sharpe AH, Hatfield DL, Gladyshev VN. Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins. Cell Reports. 23: 1387-1398. PMID 29719252 DOI: 10.1016/J.Celrep.2018.04.009 |
0.314 |
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| 2018 |
Liu HJ, Lizotte PH, Du H, Speranza MC, Lam HC, Vaughan S, Alesi N, Wong KK, Freeman GJ, Sharpe AH, Henske EP. TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy. Jci Insight. 3. PMID 29669930 DOI: 10.1172/Jci.Insight.98674 |
0.466 |
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| 2018 |
Ahn E, Araki K, Hashimoto M, Li W, Riley JL, Cheung J, Sharpe AH, Freeman GJ, Irving BA, Ahmed R. Role of PD-1 during effector CD8 T cell differentiation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29654146 DOI: 10.1073/Pnas.1718217115 |
0.536 |
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| 2018 |
Sage PT, Schildberg FA, Sobel RA, Kuchroo VK, Freeman GJ, Sharpe AH. Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function. Journal of Immunology (Baltimore, Md. : 1950). PMID 29531164 DOI: 10.4049/Jimmunol.1701231 |
0.726 |
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| 2018 |
Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA. Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 29475985 DOI: 10.4049/Jimmunol.1800150 |
0.723 |
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| 2018 |
LaFleur MW, Muroyama Y, Drake CG, Sharpe AH. Inhibitors of the PD-1 Pathway in Tumor Therapy. Journal of Immunology (Baltimore, Md. : 1950). 200: 375-383. PMID 29311378 DOI: 10.4049/Jimmunol.1701044 |
0.389 |
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| 2018 |
Juchem KW, Sacirbegovic F, Zhang C, Sharpe AH, Russell K, McNiff JM, Demetris AJ, Shlomchik MJ, Shlomchik WD. PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease. Journal of Immunology (Baltimore, Md. : 1950). 200: 834-846. PMID 29212909 DOI: 10.4049/Jimmunol.1701076 |
0.449 |
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| 2018 |
Pignon J, Jegede O, Horak C, Wind-Rotolo M, Catalano PJ, Grosha J, Flaifel A, Novak J, Mahoney KM, Freeman GJ, Sharpe A, Wu CJ, Hodi FS, Motzer RJ, Choueiri TK, et al. Evaluation of predictive biomarkers for nivolumab in metastatic clear cell renal cell carcinoma (mccRCC) using RECIST and immune-related (IR) RECIST. Journal of Clinical Oncology. 36: 619-619. DOI: 10.1200/Jco.2018.36.6_Suppl.619 |
0.439 |
|
| 2018 |
Pauken KE, Juneja VR, Sage PT, LaFleur MW, Kuchroo JR, Ringel A, Ron-Harel N, Maleri SP, Freeman GJ, Chevrier N, Haigis MC, Sharpe AH. Abstract A19: PD-1 modulation promotes antitumor immunity by improving metabolic fitness of both PD-1+ and PD-1- CD8+ T cells in the tumor Cancer Immunology Research. 6. DOI: 10.1158/2326-6074.Tumimm17-A19 |
0.736 |
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| 2018 |
Miller BC, Sen DR, Al-Abosy R, Bi K, Yates KB, Gjini E, Felt K, Manguso RT, Rodig SJ, Sharpe AH, Haining N. Abstract 4683: Distinct subsets of dysfunctional CD8+ T cells underlie response to checkpoint blockade Cancer Research. 78: 4683-4683. DOI: 10.1158/1538-7445.Am2018-4683 |
0.533 |
|
| 2018 |
Liu H, Lizotte P, Du H, Speranza M, Vaughan S, Alesi N, Wong K, Freeman G, Sharpe A, Henske E. Abstract 1686: TSC2 enhances antitumor immunity and potentiates PD-1 and CTLA-4 blockade Cancer Research. 78: 1686-1686. DOI: 10.1158/1538-7445.Am2018-1686 |
0.435 |
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| 2018 |
Devi K, Kim T, Nirschl C, Liu Y, Haitz K, Gulati N, Wu P, Fuentes-Duculan J, Schmults C, Krueger J, Yoon C, Sage P, Sharpe A, Anandasabapathy N. 121 TRM recall is critically governed by PD-1:PD-L1/2 cross-talk with classical DCs Journal of Investigative Dermatology. 138: S21. DOI: 10.1016/J.Jid.2018.03.125 |
0.66 |
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| 2017 |
Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA. B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 29093061 DOI: 10.4049/Jimmunol.1700409 |
0.75 |
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| 2017 |
Sharpe AH, Pauken KE. The diverse functions of the PD1 inhibitory pathway. Nature Reviews. Immunology. PMID 28990585 DOI: 10.1038/Nri.2017.108 |
0.488 |
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| 2017 |
Afik S, Yates KB, Bi K, Darko S, Godec J, Gerdemann U, Swadling L, Douek DC, Klenerman P, Barnes EJ, Sharpe AH, Haining WN, Yosef N. Targeted reconstruction of T cell receptor sequence from single cell RNA-seq links CDR3 length to T cell differentiation state. Nucleic Acids Research. 45: e148. PMID 28934479 DOI: 10.1093/Nar/Gkx615 |
0.494 |
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| 2017 |
Manguso RT, Pope HW, Zimmer MD, Brown FD, Yates KB, Miller BC, Collins NB, Bi K, LaFleur MW, Juneja VR, Weiss SA, Lo J, Fisher DE, Miao D, Van Allen E, ... ... Sharpe AH, et al. In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target. Nature. PMID 28723893 DOI: 10.1038/Nature23270 |
0.412 |
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| 2017 |
Moffett HF, Cartwright ANR, Kim HJ, Godec J, Pyrdol J, Äijö T, Martinez GJ, Rao A, Lu J, Golub TR, Cantor H, Sharpe AH, Novina CD, Wucherpfennig KW. The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection. Nature Immunology. PMID 28530712 DOI: 10.1038/Ni.3755 |
0.432 |
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| 2017 |
Juneja VR, McGuire KA, Manguso RT, LaFleur MW, Collins N, Haining WN, Freeman GJ, Sharpe AH. PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity. The Journal of Experimental Medicine. PMID 28302645 DOI: 10.1084/Jem.20160801 |
0.446 |
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| 2017 |
Kamphorst AO, Wieland A, Nasti T, Yang S, Zhang R, Barber DL, Konieczny BT, Daugherty CZ, Koenig L, Yu K, Sica GL, Sharpe AH, Freeman GJ, Blazar BR, Turka LA, et al. Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science (New York, N.Y.). PMID 28280249 DOI: 10.1126/Science.Aaf0683 |
0.521 |
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| 2017 |
Miller BC, Wadsworth MH, Bi K, Hughes TK, Sharpe AH, Shalek AK, Haining WN. Abstract PR11: Dissecting mechanisms of PD-1 blockade with single-cell RNA-sequencing Cancer Immunology Research. 5. DOI: 10.1158/2326-6074.Tumimm16-Pr11 |
0.479 |
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| 2017 |
Neagu MR, Manguso RT, Pope H, Speranza MC, Freeman GJ, Doench J, Sharpe AH, Haining WN. Abstract 417: Defining molecular mechanisms of resistance to glioblastoma immunity using a novel CRISPR/Cas9in vivoloss-of-function screening platform Cancer Research. 77: 417-417. DOI: 10.1158/1538-7445.Am2017-417 |
0.362 |
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| 2017 |
Miller BC, Wadsworth MH, Bi K, Hughes TK, Manguso R, Sharpe AH, Shalek AK, Haining N. Abstract 3027: Dissecting mechanisms of anti-PD-1 therapy with massively parallel single-cell RNA-sequencing Immunology. 77: 3027-3027. DOI: 10.1158/1538-7445.Am2017-3027 |
0.35 |
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| 2017 |
Manguso RT, Pope HW, Zimmer MD, Brown FD, Yates KB, Miller BC, Collins NB, Bi K, Lafleur MW, Juneja VR, Weiss SA, Fisher DE, Root DE, Sharpe AH, Doench JG, et al. Abstract 1019:In vivoCRISPR screening identifies Ptpn2 as a target for cancer immunotherapy Cancer Research. 77: 1019-1019. DOI: 10.1158/1538-7445.Am2017-1019 |
0.451 |
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| 2017 |
Devi K, Nirschl C, Liu Y, Yoon C, Clark R, Wu P, Sage P, Sharpe A, Anandasabapathy N. 051 Loss of PDL1/L2 but not PDL1 liberates DC based priming of T cells Journal of Investigative Dermatology. 137: S9. DOI: 10.1016/J.Jid.2017.02.064 |
0.691 |
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| 2016 |
Rigas D, Lewis G, Aron JL, Wang B, Banie H, Sankaranarayanan I, Galle-Treger L, Maazi H, Lo R, Freeman GJ, Sharpe AH, Soroosh P, Akbari O. ILC2 Suppression by Regulatory T Cells Attenuates Airway Hyperreactivity and Requires ICOS:ICOS-Ligand Interaction. The Journal of Allergy and Clinical Immunology. PMID 27717665 DOI: 10.1016/J.Jaci.2016.08.034 |
0.461 |
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| 2016 |
Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH. Suppression by TFR cells leads to durable and selective inhibition of B cell effector function. Nature Immunology. PMID 27695002 DOI: 10.1038/Ni.3578 |
0.722 |
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| 2016 |
McArdel SL, Brown DR, Sobel RA, Sharpe AH. Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 27581174 DOI: 10.4049/Jimmunol.1600706 |
0.427 |
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| 2016 |
Karunarathne DS, Horne-Debets JM, Huang JX, Faleiro R, Leow CY, Amante F, Watkins TS, Miles JJ, Dwyer PJ, Stacey KJ, Yarski M, Poh CM, Lee JS, Cooper MA, Rénia L, ... ... Sharpe AH, et al. Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity. Immunity. 45: 333-345. PMID 27533014 DOI: 10.1016/J.Immuni.2016.07.017 |
0.481 |
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| 2016 |
Im SJ, Hashimoto M, Gerner MY, Lee J, Kissick HT, Burger MC, Shan Q, Hale JS, Lee J, Nasti TH, Sharpe AH, Freeman GJ, Germain RN, Nakaya HI, Xue HH, et al. Defining CD8(+) T cells that provide the proliferative burst after PD-1 therapy. Nature. PMID 27501248 DOI: 10.1038/Nature19330 |
0.543 |
|
| 2016 |
Dobbins J, Gagnon E, Godec J, Pyrdol J, Vignali DA, Sharpe AH, Wucherpfennig KW. Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling. Science Signaling. 9: ra75. PMID 27460989 DOI: 10.1126/Scisignal.Aaf0626 |
0.379 |
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| 2016 |
Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M, Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MC. Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metabolism. 24: 104-17. PMID 27411012 DOI: 10.1016/J.Cmet.2016.06.007 |
0.697 |
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| 2016 |
Chen PL, Roh W, Reuben A, Cooper ZA, Spencer CN, Prieto PA, Miller JP, Bassett RL, Gopalakrishnan V, Wani K, Petaccia De Macedo M, Austin-Breneman JL, Jiang H, Chang Q, Reddy SM, ... ... Sharpe AH, et al. Analysis of immune signatures in longitudinal tumor samples yields insight into biomarkers of response and mechanisms of resistance to immune checkpoint blockade. Cancer Discovery. PMID 27301722 DOI: 10.1158/2159-8290.Cd-15-1545 |
0.367 |
|
| 2016 |
Saha A, O'Connor RS, Thangavelu G, Lovitch SB, Dandamudi DB, Wilson CB, Vincent BG, Tkachev V, Pawlicki JM, Furlan SN, Kean LS, Aoyama K, Taylor PA, Panoskaltsis-Mortari A, Foncea R, ... ... Sharpe AH, et al. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. The Journal of Clinical Investigation. PMID 27294527 DOI: 10.1172/Jci85796 |
0.516 |
|
| 2016 |
Sakai S, Kauffman KD, Sallin MA, Sharpe AH, Young HA, Ganusov VV, Barber DL. CD4 T Cell-Derived IFN-γ Plays a Minimal Role in Control of Pulmonary Mycobacterium tuberculosis Infection and Must Be Actively Repressed by PD-1 to Prevent Lethal Disease. Plos Pathogens. 12: e1005667. PMID 27244558 DOI: 10.1371/Journal.Ppat.1005667 |
0.5 |
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| 2016 |
Schildberg FA, Klein SR, Freeman GJ, Sharpe AH. Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family. Immunity. 44: 955-972. PMID 27192563 DOI: 10.1016/J.Immuni.2016.05.002 |
0.409 |
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| 2016 |
Cooper ZA, Reuben A, Spencer CN, Prieto PA, Austin-Breneman JL, Jiang H, Haymaker C, Gopalakrishnan V, Tetzlaff MT, Frederick DT, Sullivan RJ, Amaria RN, Patel SP, Hwu P, Woodman SE, ... ... Sharpe AH, et al. Distinct clinical patterns and immune infiltrates are observed at time of progression on targeted therapy versus immune checkpoint blockade for melanoma. Oncoimmunology. 5: e1136044. PMID 27141370 DOI: 10.1080/2162402X.2015.1136044 |
0.359 |
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| 2016 |
Sage PT, Sharpe AH. T follicular regulatory cells. Immunological Reviews. 271: 246-59. PMID 27088919 DOI: 10.1111/Imr.12411 |
0.726 |
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| 2016 |
Baumeister SH, Freeman GJ, Dranoff G, Sharpe AH. Coinhibitory Pathways in Immunotherapy for Cancer. Annual Review of Immunology. PMID 26927206 DOI: 10.1146/Annurev-Immunol-032414-112049 |
0.378 |
|
| 2016 |
McArdel SL, Terhorst C, Sharpe AH. Roles of CD48 in regulating immunity and tolerance. Clinical Immunology (Orlando, Fla.). 164: 10-20. PMID 26794910 DOI: 10.1016/J.Clim.2016.01.008 |
0.446 |
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| 2016 |
Sharpe AH. Abstract IA02: Biology of the PD-1 pathway Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-Ia02 |
0.446 |
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| 2016 |
McGuire KA, Juneja VR, Manguso RT, LaFleur MW, Collins N, Haining WN, Freeman GJ, Sharpe AH. Abstract A097: Tumor PDL1 blocks CTL cytotoxicity Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-A097 |
0.456 |
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| 2016 |
Sharpe AH. Abstract IA04: Multifaceted functions of the PD-1 pathway Cancer Research. 76. DOI: 10.1158/1538-7445.Fbcr15-Ia04 |
0.446 |
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| 2016 |
Kamphorst AO, Wieland A, Yang S, Nasti T, Zhang R, Barber DL, Konieczny BT, Koenig L, Yu K, Sica G, Owonikoko TK, Pillai R, Ramalingam SS, Sharpe AH, Freeman GJ, et al. Abstract 4359: Rescue of exhausted CD8 T cells by PD-1 targeted therapies is CD28-dependent Cancer Research. 76: 4359-4359. DOI: 10.1158/1538-7445.Am2016-4359 |
0.545 |
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| 2016 |
Kilgour E, Angell H, Kim K, Ahn S, Kim ST, Sharpe A, Ogden J, Davenport A, Barrett JC, Hodgson D, Lee J. Programmed death-ligand 1 (PD-L1) and immune infiltrates are prognostic for better outcome and enriched in the ATM (ataxia telangiectasia mutated)-low segment of gastric cancer (GC) Annals of Oncology. 27. DOI: 10.1093/Annonc/Mdw371.16 |
0.318 |
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| 2016 |
Miller B, Wadsworth M, Bi K, Hughes T, Sharpe A, Shalek A, Haining W. Single-Cell RNA-Seq Allows Deep Analysis of the Tumor Immune Microenvironment and Alterations Induced by Anti-PD-1 Treatment Clinical Lymphoma Myeloma and Leukemia. 16: S127. DOI: 10.1016/J.Clml.2016.07.187 |
0.389 |
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| 2015 |
Sharma MD, Shinde R, McGaha TL, Huang L, Holmgaard RB, Wolchok JD, Mautino MR, Celis E, Sharpe AH, Francisco LM, Powell JD, Yagita H, Mellor AL, Blazar BR, Munn DH. The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Science Advances. 1: e1500845. PMID 26601142 DOI: 10.1126/Sciadv.1500845 |
0.395 |
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| 2015 |
Reardon DA, Gokhale PC, Klein SR, Ligon KL, Rodig SJ, Ramkissoon SH, Jones KL, Saur Conway A, Liao X, Zhou J, Wen PY, Van den Abbeele AD, Hodi FS, Qin L, Kohl NE, ... Sharpe AH, et al. Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model. Cancer Immunology Research. PMID 26546453 DOI: 10.1158/2326-6066.Cir-15-0151 |
0.423 |
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| 2015 |
Mahoney KM, Sun H, Liao X, Hua P, Callea M, Greenfield EA, Hodi FS, Sharpe AH, Signoretti S, Rodig SJ, Freeman GJ. PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells. Cancer Immunology Research. PMID 26546452 DOI: 10.1158/2326-6066.Cir-15-0116 |
0.402 |
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| 2015 |
Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJ, Klenerman P, Sharpe AH, et al. CD39 Expression Identifies Terminally Exhausted CD8+ T Cells. Plos Pathogens. 11: e1005177. PMID 26485519 DOI: 10.1371/Journal.Ppat.1005177 |
0.509 |
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| 2015 |
Paterson AM, Lovitch SB, Sage PT, Juneja VR, Lee Y, Trombley JD, Arancibia-Cárcamo CV, Sobel RA, Rudensky AY, Kuchroo VK, Freeman GJ, Sharpe AH. Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity. The Journal of Experimental Medicine. 212: 1603-21. PMID 26371185 DOI: 10.1084/Jem.20141030 |
0.752 |
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| 2015 |
Kleffel S, Posch C, Barthel SR, Mueller H, Schlapbach C, Guenova E, Elco CP, Lee N, Juneja VR, Zhan Q, Lian CG, Thomi R, Hoetzenecker W, Cozzio A, Dummer R, ... ... Sharpe AH, et al. Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth. Cell. 162: 1242-56. PMID 26359984 DOI: 10.1016/J.Cell.2015.08.052 |
0.409 |
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| 2015 |
Schatton T, Yang J, Kleffel S, Uehara M, Barthel SR, Schlapbach C, Zhan Q, Dudeney S, Mueller H, Lee N, de Vries JC, Meier B, Vander Beken S, Kluth MA, Ganss C, ... Sharpe AH, et al. ABCB5 Identifies Immunoregulatory Dermal Cells. Cell Reports. 12: 1564-74. PMID 26321644 DOI: 10.1016/J.Celrep.2015.08.010 |
0.528 |
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| 2015 |
Sage PT, Tan CL, Freeman GJ, Haigis M, Sharpe AH. Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging. Cell Reports. 12: 163-71. PMID 26146074 DOI: 10.1016/J.Celrep.2015.06.015 |
0.709 |
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| 2015 |
Sage PT, Sharpe AH. T follicular regulatory cells in the regulation of B cell responses. Trends in Immunology. 36: 410-8. PMID 26091728 DOI: 10.1016/J.It.2015.05.005 |
0.745 |
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| 2015 |
Odorizzi PM, Pauken KE, Paley MA, Sharpe A, Wherry EJ. Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells. The Journal of Experimental Medicine. 212: 1125-37. PMID 26034050 DOI: 10.1084/Jem.20142237 |
0.536 |
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| 2015 |
Khor B, Gagnon JD, Goel G, Roche MI, Conway KL, Tran K, Aldrich LN, Sundberg TB, Paterson AM, Mordecai S, Dombkowski D, Schirmer M, Tan PH, Bhan AK, Roychoudhuri R, ... ... Sharpe AH, et al. The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells. Elife. 4. PMID 25998054 DOI: 10.7554/Elife.05920 |
0.418 |
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| 2015 |
Wang N, Halibozek PJ, Yigit B, Zhao H, O'Keeffe MS, Sage P, Sharpe A, Terhorst C. Negative Regulation of Humoral Immunity Due to Interplay between the SLAMF1, SLAMF5, and SLAMF6 Receptors. Frontiers in Immunology. 6: 158. PMID 25926831 DOI: 10.3389/Fimmu.2015.00158 |
0.727 |
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| 2015 |
Sage PT, Sharpe AH. In vitro assay to sensitively measure T(FR) suppressive capacity and T(FH) stimulation of B cell responses. Methods in Molecular Biology (Clifton, N.J.). 1291: 151-60. PMID 25836309 DOI: 10.1007/978-1-4939-2498-1_13 |
0.735 |
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| 2015 |
Lina TT, Alzahrani S, House J, Yamaoka Y, Sharpe AH, Rampy BA, Pinchuk IV, Reyes VE. Helicobacter pylori cag pathogenicity island's role in B7-H1 induction and immune evasion. Plos One. 10: e0121841. PMID 25807464 DOI: 10.1371/Journal.Pone.0121841 |
0.332 |
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| 2015 |
Maazi H, Patel N, Sankaranarayanan I, Suzuki Y, Rigas D, Soroosh P, Freeman GJ, Sharpe AH, Akbari O. ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity. Immunity. 42: 538-51. PMID 25769613 DOI: 10.1016/J.Immuni.2015.02.007 |
0.374 |
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| 2015 |
Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone JA, Turka LA. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nature Immunology. 16: 188-96. PMID 25559257 DOI: 10.1038/Ni.3077 |
0.737 |
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| 2015 |
Godec J, Cowley GS, Barnitz RA, Alkan O, Root DE, Sharpe AH, Haining WN. Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation. Proceedings of the National Academy of Sciences of the United States of America. 112: 512-7. PMID 25548173 DOI: 10.1073/Pnas.1413291112 |
0.52 |
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| 2015 |
Schildberg FA, Sharpe AH, Turley SJ. Hepatic immune regulation by stromal cells. Current Opinion in Immunology. 32: 1-6. PMID 25463592 DOI: 10.1016/J.Coi.2014.10.002 |
0.421 |
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| 2015 |
Tuladhar R, Oghumu S, Dong R, Peterson A, Sharpe AH, Satoskar AR. Ox40L-Ox40 pathway plays distinct roles in regulating Th2 responses but does not determine outcome of cutaneous leishmaniasis caused by Leishmania mexicana and Leishmania major. Experimental Parasitology. 148: 49-55. PMID 25447125 DOI: 10.1016/J.Exppara.2014.11.002 |
0.329 |
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| 2015 |
Ron-Harel N, Sharpe AH, Haigis MC. Mitochondrial metabolism in T cell activation and senescence: a mini-review. Gerontology. 61: 131-8. PMID 25402204 DOI: 10.1159/000362502 |
0.455 |
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| 2015 |
Oghumu S, Stock JC, Varikuti S, Dong R, Terrazas C, Edwards JA, Rappleye CA, Holovatyk A, Sharpe A, Satoskar AR. Transgenic expression of CXCR3 on T cells enhances susceptibility to cutaneous Leishmania major infection by inhibiting monocyte maturation and promoting a Th2 response. Infection and Immunity. 83: 67-76. PMID 25312956 DOI: 10.1128/Iai.02540-14 |
0.435 |
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| 2015 |
Khor B, Gagnon JD, Goel G, Roche MI, Conway KL, Tran K, Aldrich LN, Sundberg TB, Paterson AM, Mordecai S, Dombkowski D, Schirmer M, Tan PH, Bhan AK, Roychoudhuri R, ... ... Sharpe AH, et al. Author response: The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells Elife. DOI: 10.7554/Elife.05920.028 |
0.417 |
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| 2015 |
Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJR, Klenerman P, Sharpe AH, et al. Terminally exhausted CD8 + T cells marked by high levels of CD39 are most impaired in their effector function. Plos Pathogens. DOI: 10.1371/Journal.Ppat.1005177.G007 |
0.424 |
|
| 2015 |
Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJR, Klenerman P, Sharpe AH, et al. CD39 is highly up-regulated by exhausted CD8 + T cells in a mouse model of chronic infection. Plos Pathogens. DOI: 10.1371/Journal.Ppat.1005177.G005 |
0.422 |
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| 2015 |
Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJR, Klenerman P, Sharpe AH, et al. CD39 expression correlates with PD-1 expression and viral load in chronic viral infection. Plos Pathogens. DOI: 10.1371/Journal.Ppat.1005177.G003 |
0.348 |
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| 2015 |
Gupta PK, Godec J, Wolski D, Adland E, Yates K, Pauken KE, Cosgrove C, Ledderose C, Junger WG, Robson SC, Wherry EJ, Alter G, Goulder PJR, Klenerman P, Sharpe AH, et al. CD39 expressed by CD8 + T cells in HCV infection is enzymatically active. Plos Pathogens. DOI: 10.1371/Journal.Ppat.1005177.G002 |
0.39 |
|
| 2015 |
Nirschl C, Liu Y, Sarin K, Suarez-Farinas M, Chau D, Sage P, Sharpe A, Anandasabapathy N. Core skin DC signatures control immune tolerance to skin cancer and limit anti-tumor immunity Journal For Immunotherapy of Cancer. 3: P205. DOI: 10.1186/2051-1426-3-S2-P205 |
0.642 |
|
| 2015 |
Sharma M, Shinde R, McGaha T, Huang L, Holmgaard R, Wolchok J, Mautino M, Celis E, Sharpe A, Francisco L, Powell J, Yagita H, Mellor A, Blazar B, Munn D. The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells Journal For Immunotherapy of Cancer. 3: O19. DOI: 10.1186/2051-1426-3-S2-O19 |
0.462 |
|
| 2015 |
Blazar BR, O'Connor RS, Milone MC, Dustin ML, Riley JL, Vincent BG, Serody JS, Flynn RP, Paz K, Du J, Panoskaltsis-Mortari A, Jeffrey M, Ahmed R, Turka LAA, Freeman GJ, ... Sharpe AH, et al. Role of PD-1/PD-L1 in Acute and Chronic Graft Versus Host Disease Blood. 126: SCI-8-SCI-8. DOI: 10.1182/Blood.V126.23.Sci-8.Sci-8 |
0.479 |
|
| 2015 |
Saha A, O'Connor RS, Thangavelu G, Lovitch SB, Dandamudi DB, Wilson CB, Vincent BG, Aoyama K, Taylor PA, Panoskaltsis-Mortari A, Foncea R, Burrill JS, Guo L, Sacristan C, Furlan SN, ... ... Sharpe AH, et al. Loss of Programmed Death Ligand-1 Expression on Donor T Cells Lessens Acute Graft-Versus-Host Disease Lethality Blood. 126: 147-147. DOI: 10.1182/Blood.V126.23.147.147 |
0.554 |
|
| 2014 |
Sage PT, Paterson AM, Lovitch SB, Sharpe AH. The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells. Immunity. 41: 1026-39. PMID 25526313 DOI: 10.1016/J.Immuni.2014.12.005 |
0.734 |
|
| 2014 |
Gubin MM, Zhang X, Schuster H, Caron E, Ward JP, Noguchi T, Ivanova Y, Hundal J, Arthur CD, Krebber WJ, Mulder GE, Toebes M, Vesely MD, Lam SS, Korman AJ, ... ... Sharpe AH, et al. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature. 515: 577-81. PMID 25428507 DOI: 10.1038/Nature13988 |
0.432 |
|
| 2014 |
Sage PT, Alvarez D, Godec J, von Andrian UH, Sharpe AH. Circulating T follicular regulatory and helper cells have memory-like properties. The Journal of Clinical Investigation. 124: 5191-204. PMID 25347469 DOI: 10.1172/Jci76861 |
0.703 |
|
| 2014 |
Penaloza-MacMaster P, Kamphorst AO, Wieland A, Araki K, Iyer SS, West EE, O'Mara L, Yang S, Konieczny BT, Sharpe AH, Freeman GJ, Rudensky AY, Ahmed R. Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. The Journal of Experimental Medicine. 211: 1905-18. PMID 25113973 DOI: 10.1084/Jem.20132577 |
0.581 |
|
| 2014 |
Wolf AI, Strauman MC, Mozdzanowska K, Whittle JR, Williams KL, Sharpe AH, Weiser JN, Caton AJ, Hensley SE, Erikson J. Coinfection with Streptococcus pneumoniae modulates the B cell response to influenza virus. Journal of Virology. 88: 11995-2005. PMID 25100838 DOI: 10.1128/Jvi.01833-14 |
0.382 |
|
| 2014 |
Cooper ZA, Juneja VR, Sage PT, Frederick DT, Piris A, Mitra D, Lo JA, Hodi FS, Freeman GJ, Bosenberg MW, McMahon M, Flaherty KT, Fisher DE, Sharpe AH, Wargo JA. Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade. Cancer Immunology Research. 2: 643-54. PMID 24903021 DOI: 10.1158/2326-6066.Cir-13-0215 |
0.712 |
|
| 2014 |
Xiao Y, Yu S, Zhu B, Bedoret D, Bu X, Francisco LM, Hua P, Duke-Cohan JS, Umetsu DT, Sharpe AH, DeKruyff RH, Freeman GJ. RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. The Journal of Experimental Medicine. 211: 943-59. PMID 24752301 DOI: 10.1084/Jem.20130790 |
0.442 |
|
| 2014 |
Joller N, Lozano E, Burkett PR, Patel B, Xiao S, Zhu C, Xia J, Tan TG, Sefik E, Yajnik V, Sharpe AH, Quintana FJ, Mathis D, Benoist C, Hafler DA, et al. Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses. Immunity. 40: 569-81. PMID 24745333 DOI: 10.1016/J.Immuni.2014.02.012 |
0.482 |
|
| 2014 |
Mott KR, Allen SJ, Zandian M, Akbari O, Hamrah P, Maazi H, Wechsler SL, Sharpe AH, Freeman GJ, Ghiasi H. Inclusion of CD80 in HSV targets the recombinant virus to PD-L1 on DCs and allows productive infection and robust immune responses. Plos One. 9: e87617. PMID 24475315 DOI: 10.1371/Journal.Pone.0087617 |
0.429 |
|
| 2014 |
Sage PT, Paterson AM, Lovitch SB, Sharpe AH. The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells Immunity. 41: 1026-1039. DOI: 10.1016/j.immuni.2014.12.005 |
0.702 |
|
| 2013 |
Horne-Debets JM, Faleiro R, Karunarathne DS, Liu XQ, Lineburg KE, Poh CM, Grotenbreg GM, Hill GR, MacDonald KP, Good MF, Renia L, Ahmed R, Sharpe AH, Wykes MN. PD-1 dependent exhaustion of CD8+ T cells drives chronic malaria. Cell Reports. 5: 1204-13. PMID 24316071 DOI: 10.1016/J.Celrep.2013.11.002 |
0.441 |
|
| 2013 |
Cooper ZA, Frederick DT, Juneja VR, Sullivan RJ, Lawrence DP, Piris A, Sharpe AH, Fisher DE, Flaherty KT, Wargo JA. BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes. Oncoimmunology. 2: e26615. PMID 24251082 DOI: 10.4161/Onci.26615 |
0.396 |
|
| 2013 |
Saha A, Aoyama K, Taylor PA, Koehn BH, Veenstra RG, Panoskaltsis-Mortari A, Munn DH, Murphy WJ, Azuma M, Yagita H, Fife BT, Sayegh MH, Najafian N, Socie G, Ahmed R, ... ... Sharpe AH, et al. Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality. Blood. 122: 3062-73. PMID 24030385 DOI: 10.1182/Blood-2013-05-500801 |
0.439 |
|
| 2013 |
Mukherjee G, Geliebter A, Babad J, Santamaria P, Serreze DV, Freeman GJ, Tarbell KV, Sharpe A, DiLorenzo TP. DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8⁺ T cells independently of PD-1 and PD-L1. International Immunology. 25: 651-60. PMID 24021877 DOI: 10.1093/Intimm/Dxt031 |
0.545 |
|
| 2013 |
Fuller MJ, Callendret B, Zhu B, Freeman GJ, Hasselschwert DL, Satterfield W, Sharpe AH, Dustin LB, Rice CM, Grakoui A, Ahmed R, Walker CM. Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1). Proceedings of the National Academy of Sciences of the United States of America. 110: 15001-6. PMID 23980172 DOI: 10.1073/Pnas.1312772110 |
0.431 |
|
| 2013 |
Riella LV, Dada S, Chabtini L, Smith B, Huang L, Dakle P, Mfarrej B, D'Addio F, Adams LT, Kochupurakkal N, Vergani A, Fiorina P, Mellor AL, Sharpe AH, Yagita H, et al. B7h (ICOS-L) maintains tolerance at the fetomaternal interface. The American Journal of Pathology. 182: 2204-13. PMID 23578385 DOI: 10.1016/J.Ajpath.2013.02.014 |
0.465 |
|
| 2013 |
Maazi H, Singh AK, Speak AO, Lombardi V, Lam J, Khoo B, Inn KS, Sharpe AH, Jung JU, Akbari O. Lack of PD-L1 expression by iNKT cells improves the course of influenza A infection. Plos One. 8: e59599. PMID 23555047 DOI: 10.1371/Journal.Pone.0059599 |
0.449 |
|
| 2013 |
Oghumu S, Dong R, Varikuti S, Shawler T, Kampfrath T, Terrazas CA, Lezama-Davila C, Ahmer BM, Whitacre CC, Rajagopalan S, Locksley R, Sharpe AH, Satoskar AR. Distinct populations of innate CD8+ T cells revealed in a CXCR3 reporter mouse. Journal of Immunology (Baltimore, Md. : 1950). 190: 2229-40. PMID 23338236 DOI: 10.4049/Jimmunol.1201170 |
0.499 |
|
| 2013 |
Chang SY, Song JH, Guleng B, Cotoner CA, Arihiro S, Zhao Y, Chiang HS, O'Keeffe M, Liao G, Karp CL, Kweon MN, Sharpe AH, Bhan A, Terhorst C, Reinecker HC. Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation. Immunity. 38: 153-65. PMID 23246312 DOI: 10.1016/J.Immuni.2012.09.018 |
0.475 |
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| 2013 |
Sage PT, Francisco LM, Carman CV, Sharpe AH. The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood. Nature Immunology. 14: 152-61. PMID 23242415 DOI: 10.1038/Ni.2496 |
0.766 |
|
| 2013 |
Ichinose K, Zhang Z, Koga T, Juang YT, Kis-Tóth K, Sharpe AH, Kuchroo V, Crispín JC, Tsokos GC. Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice. Arthritis and Rheumatism. 65: 764-9. PMID 23203389 DOI: 10.1002/Art.37790 |
0.421 |
|
| 2013 |
Juchem KW, Anderson B, Zhang C, Sharpe A, McNiff J, Demetris A, Shlomchik MJ, Shlomchik WD. PD-L1 and PD-L2 Protect The Heart In a T-Cell Receptor Transgenic Model Of Graft-Versus Host Disease Blood. 122: 4479-4479. DOI: 10.1182/Blood.V122.21.4479.4479 |
0.502 |
|
| 2012 |
Riella LV, Paterson AM, Sharpe AH, Chandraker A. Role of the PD-1 pathway in the immune response American Journal of Transplantation. 12: 2575-2587. PMID 22900886 DOI: 10.1111/J.1600-6143.2012.04224.X |
0.478 |
|
| 2012 |
Butte MJ, Lee SJ, Jesneck J, Keir ME, Haining WN, Sharpe AH. CD28 costimulation regulates genome-wide effects on alternative splicing. Plos One. 7: e40032. PMID 22768209 DOI: 10.1371/Journal.Pone.0040032 |
0.451 |
|
| 2012 |
Hirahara K, Ghoreschi K, Yang XP, Takahashi H, Laurence A, Vahedi G, Sciumè G, Hall AO, Dupont CD, Francisco LM, Chen Q, Tanaka M, Kanno Y, Sun HW, Sharpe AH, et al. Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1. Immunity. 36: 1017-30. PMID 22726954 DOI: 10.1016/J.Immuni.2012.03.024 |
0.506 |
|
| 2012 |
Sham CW, Chan AM, Kwong JM, Caprioli J, Nusinowitz S, Chen B, Lee JG, Gandhi NM, Francisco LM, Sharpe AH, Chen L, Braun J, Gordon LK. Neuronal programmed cell death-1 ligand expression regulates retinal ganglion cell number in neonatal and adult mice. Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society. 32: 227-37. PMID 22635166 DOI: 10.1097/Wno.0B013E3182589589 |
0.402 |
|
| 2012 |
Silberman D, Bucknum A, Bartlett T, Composto G, Kozlowski M, Walker A, Werda A, Cua J, Sharpe AH, Somerville JE, Riggs JE. CD28 ligation increases macrophage suppression of T-cell proliferation. Cellular & Molecular Immunology. 9: 341-9. PMID 22522653 DOI: 10.1038/Cmi.2012.13 |
0.538 |
|
| 2012 |
Tarrio ML, Grabie N, Bu DX, Sharpe AH, Lichtman AH. PD-1 protects against inflammation and myocyte damage in T cell-mediated myocarditis. Journal of Immunology (Baltimore, Md. : 1950). 188: 4876-84. PMID 22491251 DOI: 10.4049/Jimmunol.1200389 |
0.575 |
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| 2012 |
Good-Jacobson KL, Song E, Anderson S, Sharpe AH, Shlomchik MJ. CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation. Journal of Immunology (Baltimore, Md. : 1950). 188: 4217-25. PMID 22450810 DOI: 10.4049/Jimmunol.1102885 |
0.541 |
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| 2012 |
Sage PT, Varghese LM, Martinelli R, Sciuto TE, Kamei M, Dvorak AM, Springer TA, Sharpe AH, Carman CV. Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells. Journal of Immunology (Baltimore, Md. : 1950). 188: 3686-99. PMID 22442443 DOI: 10.4049/Jimmunol.1102594 |
0.721 |
|
| 2012 |
Vijayanand P, Seumois G, Simpson LJ, Abdul-Wajid S, Baumjohann D, Panduro M, Huang X, Interlandi J, Djuretic IM, Brown DR, Sharpe AH, Rao A, Ansel KM. Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V. Immunity. 36: 175-87. PMID 22326582 DOI: 10.1016/J.Immuni.2011.12.014 |
0.394 |
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| 2012 |
Freeman GJ, Sharpe AH. A new therapeutic strategy for malaria: targeting T cell exhaustion. Nature Immunology. 13: 113-5. PMID 22261959 DOI: 10.1038/Ni.2211 |
0.446 |
|
| 2012 |
Ioannou M, Alissafi T, Lazaridis I, Deraos G, Matsoukas J, Gravanis A, Mastorodemos V, Plaitakis A, Sharpe A, Boumpas D, Verginis P. Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease. Journal of Immunology (Baltimore, Md. : 1950). 188: 1136-46. PMID 22210912 DOI: 10.4049/Jimmunol.1101816 |
0.439 |
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| 2012 |
Liu SM, Sutherland APR, Zhang Z, Rainbow DB, Quintana FJ, Paterson AM, Sharpe AH, Oukka M, Wicker LS, Kuchroo VK. Overexpression of the CTLA-4 isoform lacking exons 2 and 3 causes autoimmunity Journal of Immunology. 188: 155-162. PMID 22124121 DOI: 10.4049/Jimmunol.1102042 |
0.514 |
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| 2012 |
Maldonado R, Perdomo L, Vascotto F, Francisco L, Bauquet A, Kuchroo V, Sharpe A, von Andrian U. Induced-Tolerogenic Dendritic Cells That Promote Tolerance And De Novo Differentiation Of Regulatory T Cells Journal of Allergy and Clinical Immunology. 129: AB116. DOI: 10.1016/J.Jaci.2011.12.563 |
0.48 |
|
| 2011 |
Aubert RD, Kamphorst AO, Sarkar S, Vezys V, Ha SJ, Barber DL, Ye L, Sharpe AH, Freeman GJ, Ahmed R. Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection. Proceedings of the National Academy of Sciences of the United States of America. 108: 21182-7. PMID 22160724 DOI: 10.1073/Pnas.1118450109 |
0.514 |
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| 2011 |
Baban B, Chandler PR, Johnson BA, Huang L, Li M, Sharpe ML, Francisco LM, Sharpe AH, Blazar BR, Munn DH, Mellor AL. Physiologic control of IDO competence in splenic dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 187: 2329-35. PMID 21813777 DOI: 10.4049/Jimmunol.1100276 |
0.561 |
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| 2011 |
Paterson AM, Brown KE, Keir ME, Vanguri VK, Riella LV, Chandraker A, Sayegh MH, Blazar BR, Freeman GJ, Sharpe AH. The programmed Death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo Journal of Immunology. 187: 1097-1105. PMID 21697456 DOI: 10.4049/Jimmunol.1003496 |
0.635 |
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| 2011 |
Yang J, Riella LV, Chock S, Liu T, Zhao X, Yuan X, Paterson AM, Watanabe T, Vanguri V, Yagita H, Azuma M, Blazar BR, Freeman GJ, Rodig SJ, Sharpe AH, et al. The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo Journal of Immunology. 187: 1113-1119. PMID 21697455 DOI: 10.4049/Jimmunol.1100056 |
0.49 |
|
| 2011 |
Brown DR, Calpe S, Keszei M, Wang N, McArdel S, Terhorst C, Sharpe AH. Cutting edge: an NK cell-independent role for Slamf4 in controlling humoral autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). 187: 21-5. PMID 21622868 DOI: 10.4049/Jimmunol.1100510 |
0.483 |
|
| 2011 |
Koh AE, Njoroge SW, Feliu M, Cook A, Selig MK, Latchman YE, Sharpe AH, Colvin RB, Paul E. The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis Journal of Autoimmunity. 37: 48-57. PMID 21561736 DOI: 10.1016/J.Jaut.2011.03.004 |
0.385 |
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| 2011 |
Mfarrej B, Keir M, Dada S, Trikudanathan S, Sayegh MH, Sharpe AH, Guleria I. Anti-CD3 mAb treatment cures PDL1-/-.NOD mice of diabetes but precipitates fatal myocarditis. Clinical Immunology (Orlando, Fla.). 140: 47-53. PMID 21498129 DOI: 10.1016/J.Clim.2011.03.011 |
0.337 |
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| 2011 |
Jin Y, Chauhan SK, El Annan J, Annan JE, Sage PT, Sharpe AH, Dana R. A novel function for programmed death ligand-1 regulation of angiogenesis. The American Journal of Pathology. 178: 1922-9. PMID 21435468 DOI: 10.1016/J.Ajpath.2010.12.027 |
0.715 |
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| 2011 |
Riella LV, Watanabe T, Sage PT, Yang J, Yeung M, Azzi J, Vanguri V, Chandraker A, Sharpe AH, Sayegh MH, Najafian N. Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 11: 832-40. PMID 21401869 DOI: 10.1111/J.1600-6143.2011.03451.X |
0.678 |
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| 2011 |
Bu DX, Tarrio M, Maganto-Garcia E, Stavrakis G, Tajima G, Lederer J, Jarolim P, Freeman GJ, Sharpe AH, Lichtman AH. Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 1100-7. PMID 21393583 DOI: 10.1161/Atvbaha.111.224709 |
0.446 |
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| 2011 |
Allen SJ, Hamrah P, Gate D, Mott KR, Mantopoulos D, Zheng L, Town T, Jones C, von Andrian UH, Freeman GJ, Sharpe AH, BenMohamed L, Ahmed R, Wechsler SL, Ghiasi H. The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. Journal of Virology. 85: 4184-97. PMID 21307196 DOI: 10.1128/Jvi.02290-10 |
0.516 |
|
| 2011 |
Keszei M, Latchman YE, Vanguri VK, Brown DR, Detre C, Morra M, Arancibia-Carcamo CV, Arancibia CV, Paul E, Calpe S, Castro W, Wang N, Terhorst C, Sharpe AH. Auto-antibody production and glomerulonephritis in congenic Slamf1-/- and Slamf2-/- [B6.129] but not in Slamf1-/- and Slamf2-/- [BALB/c.129] mice. International Immunology. 23: 149-58. PMID 21278219 DOI: 10.1093/Intimm/Dxq465 |
0.416 |
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| 2011 |
Joller N, Hafler JP, Brynedal B, Kassam N, Spoerl S, Levin SD, Sharpe AH, Kuchroo VK. Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. Journal of Immunology (Baltimore, Md. : 1950). 186: 1338-42. PMID 21199897 DOI: 10.4049/Jimmunol.1003081 |
0.539 |
|
| 2011 |
Barber DL, Mayer-Barber KD, Feng CG, Sharpe AH, Sher A. CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition. Journal of Immunology (Baltimore, Md. : 1950). 186: 1598-607. PMID 21172867 DOI: 10.4049/Jimmunol.1003304 |
0.513 |
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| 2011 |
Bassett M, Freeman G, Sharpe A, Turley S. Novel Role of PD-L1 in Regulating T Cell Homing to the Small Intestine Gastroenterology. 140: S-488. DOI: 10.1016/S0016-5085(11)62013-1 |
0.482 |
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| 2010 |
Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunological Reviews. 236: 219-42. PMID 20636820 DOI: 10.1111/J.1600-065X.2010.00923.X |
0.724 |
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| 2010 |
Zhou Q, Munger ME, Highfill SL, Tolar J, Weigel BJ, Riddle M, Sharpe AH, Vallera DA, Azuma M, Levine BL, June CH, Murphy WJ, Munn DH, Blazar BR. Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia. Blood. 116: 2484-93. PMID 20570856 DOI: 10.1182/Blood-2010-03-275446 |
0.53 |
|
| 2010 |
Mueller SN, Vanguri VK, Ha SJ, West EE, Keir ME, Glickman JN, Sharpe AH, Ahmed R. PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. The Journal of Clinical Investigation. 120: 2508-15. PMID 20551512 DOI: 10.1172/Jci40040 |
0.518 |
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| 2010 |
Good-Jacobson KL, Szumilas CG, Chen L, Sharpe AH, Tomayko MM, Shlomchik MJ. PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nature Immunology. 11: 535-42. PMID 20453843 DOI: 10.1038/Ni.1877 |
0.485 |
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| 2010 |
Brown KE, Freeman GJ, Wherry EJ, Sharpe AH. Role of PD-1 in regulating acute infections. Current Opinion in Immunology. 22: 397-401. PMID 20427170 DOI: 10.1016/J.Coi.2010.03.007 |
0.654 |
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| 2010 |
Paterson AM, Sharpe AH. Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells Nature Immunology. 11: 109-111. PMID 20084066 DOI: 10.1038/Ni0210-109 |
0.493 |
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| 2010 |
El Annan J, Goyal S, Zhang Q, Freeman GJ, Sharpe AH, Dana R. Regulation of T-cell chemotaxis by programmed death-ligand 1 (PD-L1) in dry eye-associated corneal inflammation. Investigative Ophthalmology & Visual Science. 51: 3418-23. PMID 20019373 DOI: 10.1167/Iovs.09-3684 |
0.478 |
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| 2010 |
Akbari O, Stock P, Singh AK, Lombardi V, Lee WL, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH. PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions Mucosal Immunology. 3: 81-91. PMID 19741598 DOI: 10.1038/Mi.2009.112 |
0.452 |
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| 2010 |
Paul E, Latchman Y, Kirby A, Koh A, Njoroge S, Feliu M, Sharpe A, Daly M, Colvin R. CD48 Deficiency Precipitates Autoimmune Glomerulonephritis in Lupus Prone Mice Clinical Immunology. 135: S10. DOI: 10.1016/J.Clim.2010.03.036 |
0.348 |
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| 2009 |
Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. The Journal of Experimental Medicine. 206: 3015-29. PMID 20008522 DOI: 10.1084/Jem.20090847 |
0.669 |
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| 2009 |
Araki M, Chung D, Liu S, Rainbow DB, Chamberlain G, Garner V, Hunter KM, Vijayakrishnan L, Peterson LB, Oukka M, Sharpe AH, Sobel R, Kuchroo VK, Wicker LS. Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice. Journal of Immunology (Baltimore, Md. : 1950). 183: 5146-57. PMID 19783679 DOI: 10.4049/Jimmunol.0802610 |
0.37 |
|
| 2009 |
Ruffner MA, Kim SH, Bianco NR, Francisco LM, Sharpe AH, Robbins PD. B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function. European Journal of Immunology. 39: 3084-90. PMID 19757438 DOI: 10.1002/Eji.200939407 |
0.39 |
|
| 2009 |
Paterson AM, Vanguri VK, Sharpe AH. SnapShot: B7/CD28 Costimulation Cell. 137: 974-974.e1. PMID 19490900 DOI: 10.1016/J.Cell.2009.05.015 |
0.342 |
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| 2009 |
Sharpe AH. Mechanisms of costimulation. Immunological Reviews. 229: 5-11. PMID 19426211 DOI: 10.1111/J.1600-065X.2009.00784.X |
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| 2009 |
Chen L, Sham CW, Chan AM, Francisco LM, Wu Y, Mareninov S, Sharpe AH, Freeman GJ, Yang XJ, Braun J, Gordon LK. Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells. Investigative Ophthalmology & Visual Science. 50: 4941-8. PMID 19420345 DOI: 10.1167/Iovs.09-3602 |
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| 2009 |
Chen L, Pai V, Levinson R, Sharpe AH, Freeman GJ, Braun J, Gordon LK. Constitutive neuronal expression of the immune regulator, programmed death 1 (PD-1), identified during experimental autoimmune uveitis. Ocular Immunology and Inflammation. 17: 47-55. PMID 19294574 DOI: 10.1080/09273940802491884 |
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| 2009 |
Verhagen J, Gabrysová L, Minaee S, Sabatos CA, Anderson G, Sharpe AH, Wraith DC. Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease. Proceedings of the National Academy of Sciences of the United States of America. 106: 3306-11. PMID 19218450 DOI: 10.1073/Pnas.0803186106 |
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| 2009 |
Reynoso ED, Elpek KG, Francisco L, Bronson R, Bellemare-Pelletier A, Sharpe AH, Freeman GJ, Turley SJ. Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade. Journal of Immunology (Baltimore, Md. : 1950). 182: 2102-12. PMID 19201863 DOI: 10.4049/Jimmunol.0802769 |
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| 2009 |
Schmidt EM, Wang CJ, Ryan GA, Clough LE, Qureshi OS, Goodall M, Abbas AK, Sharpe AH, Sansom DM, Walker LS. Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). 182: 274-82. PMID 19109158 DOI: 10.4049/Jimmunol.182.1.274 |
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| 2009 |
Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho IC, Sharpe AH, Kuchroo VK. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH -17 cells Nature Immunology. 10: 167-175. PMID 19098919 DOI: 10.1038/Ni.1690 |
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| 2009 |
Francisco L, Salinas V, Brown K, Vanguri V, Freeman G, Kuchroo V, Sharpe A. OR.100. PD-L1 Regulates the Development, Maintenance and Function of Induced-regulatory T Cells Clinical Immunology. 131: S41. DOI: 10.1016/J.Clim.2009.03.115 |
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| 2008 |
Brooks DG, Ha SJ, Elsaesser H, Sharpe AH, Freeman GJ, Oldstone MB. IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection. Proceedings of the National Academy of Sciences of the United States of America. 105: 20428-33. PMID 19075244 DOI: 10.1073/Pnas.0811139106 |
0.497 |
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| 2008 |
Gotsman I, Sharpe AH, Lichtman AH. T-cell costimulation and coinhibition in atherosclerosis. Circulation Research. 103: 1220-31. PMID 19028921 DOI: 10.1161/Circresaha.108.182428 |
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| 2008 |
Lucas JA, Menke J, Rabacal WA, Schoen FJ, Sharpe AH, Kelley VR. Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice. Journal of Immunology (Baltimore, Md. : 1950). 181: 2513-21. PMID 18684942 DOI: 10.4049/Jimmunol.181.4.2513 |
0.452 |
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| 2008 |
Taylor PA, Ehrhardt MJ, Lees CJ, Panoskaltsis-Mortari A, Krieg AM, Sharpe AH, Murphy WJ, Serody JS, Hemmi H, Akira S, Levy RB, Blazar BR. TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection. Blood. 112: 3508-16. PMID 18614760 DOI: 10.1182/Blood-2007-09-113670 |
0.367 |
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| 2008 |
Duan B, Niu H, Xu Z, Sharpe AH, Croker BP, Sobel ES, Morel L. Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus. Laboratory Investigation; a Journal of Technical Methods and Pathology. 88: 1008-20. PMID 18607347 DOI: 10.1038/Labinvest.2008.62 |
0.399 |
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| 2008 |
Butte MJ, Peña-Cruz V, Kim MJ, Freeman GJ, Sharpe AH. Interaction of human PD-L1 and B7-1. Molecular Immunology. 45: 3567-72. PMID 18585785 DOI: 10.1016/J.Molimm.2008.05.014 |
0.494 |
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| 2008 |
Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH. ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival. Journal of Immunology (Baltimore, Md. : 1950). 180: 5448-56. PMID 18390727 DOI: 10.4049/Jimmunol.180.8.5448 |
0.46 |
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| 2008 |
Ha SJ, Mueller SN, Wherry EJ, Barber DL, Aubert RD, Sharpe AH, Freeman GJ, Ahmed R. Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. The Journal of Experimental Medicine. 205: 543-55. PMID 18332181 DOI: 10.1084/Jem.20071949 |
0.437 |
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| 2008 |
Cunninghame Graham DS, Vyse TJ, Fortin PR, Montpetit A, Cai YC, Lim S, McKenzie T, Farwell L, Rhodes B, Chad L, Hudson TJ, Sharpe A, Terhorst C, Greenwood CM, Wither J, et al. Association of LY9 in UK and Canadian SLE families. Genes and Immunity. 9: 93-102. PMID 18216865 DOI: 10.1038/Sj.Gene.6364453 |
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| 2008 |
Keir ME, Butte MJ, Freeman GJ, Sharpe AH. PD-1 and its ligands in tolerance and immunity. Annual Review of Immunology. 26: 677-704. PMID 18173375 DOI: 10.1146/Annurev.Immunol.26.021607.090331 |
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| 2008 |
Sham C, Chen L, Wu Y, Sharpe A, Freeman G, Braun J, Gordon L. Su.54. Programmed Cell Death-1 Regulates Neuronal Cell Death in the Developing Mouse Retina Clinical Immunology. 127: S141-S142. DOI: 10.1016/J.Clim.2008.03.405 |
0.311 |
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| 2007 |
Kobayashi N, Karisola P, Peña-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, et al. TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity. 27: 927-40. PMID 18082433 DOI: 10.1016/J.Immuni.2007.11.011 |
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| 2007 |
Menke J, Lucas JA, Zeller GC, Keir ME, Huang XR, Tsuboi N, Mayadas TN, Lan HY, Sharpe AH, Kelley VR. Programmed death 1 ligand (PD-L) 1 and PD-L2 limit autoimmune kidney disease: distinct roles. Journal of Immunology (Baltimore, Md. : 1950). 179: 7466-77. PMID 18025191 DOI: 10.4049/Jimmunol.179.11.7466 |
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| 2007 |
Grabie N, Gotsman I, DaCosta R, Pang H, Stavrakis G, Butte MJ, Keir ME, Freeman GJ, Sharpe AH, Lichtman AH. Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart. Circulation. 116: 2062-71. PMID 17938288 DOI: 10.1161/Circulationaha.107.709360 |
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| 2007 |
Keir ME, Freeman GJ, Sharpe AH. PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues. Journal of Immunology (Baltimore, Md. : 1950). 179: 5064-70. PMID 17911591 DOI: 10.4049/Jimmunol.179.8.5064 |
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| 2007 |
Mueller SN, Matloubian M, Clemens DM, Sharpe AH, Freeman GJ, Gangappa S, Larsen CP, Ahmed R. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proceedings of the National Academy of Sciences of the United States of America. 104: 15430-5. PMID 17878315 DOI: 10.1073/Pnas.0702579104 |
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| 2007 |
Gotsman I, Grabie N, Dacosta R, Sukhova G, Sharpe A, Lichtman AH. Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice. The Journal of Clinical Investigation. 117: 2974-82. PMID 17853943 DOI: 10.1172/Jci31344 |
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| 2007 |
Shen L, Jin Y, Freeman GJ, Sharpe AH, Dana MR. The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival. Journal of Immunology (Baltimore, Md. : 1950). 179: 3672-9. PMID 17785803 DOI: 10.4049/Jimmunol.179.6.3672 |
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| 2007 |
Tai X, Van Laethem F, Sharpe AH, Singer A. Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation. Proceedings of the National Academy of Sciences of the United States of America. 104: 13756-61. PMID 17702861 DOI: 10.1073/Pnas.0706509104 |
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| 2007 |
Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity. 27: 111-22. PMID 17629517 DOI: 10.1016/J.Immuni.2007.05.016 |
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| 2007 |
Love VA, Grabie N, Duramad P, Stavrakis G, Sharpe A, Lichtman A. CTLA-4 ablation and interleukin-12 driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes. Circulation Research. 101: 248-57. PMID 17569889 DOI: 10.1161/Circresaha.106.147124 |
0.519 |
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| 2007 |
Kwan KY, Greenwald RJ, Mohanty S, Sharpe AH, Shaw AC, Wang JC. Development of autoimmunity in mice lacking DNA topoisomerase 3β Proceedings of the National Academy of Sciences of the United States of America. 104: 9242-9247. PMID 17517607 DOI: 10.1073/Pnas.0703587104 |
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| 2007 |
Kim G, Levin M, Schoenberger SP, Sharpe A, Kronenberg M. Paradoxical effect of reduced costimulation in T cell-mediated colitis. Journal of Immunology (Baltimore, Md. : 1950). 178: 5563-70. PMID 17442938 DOI: 10.4049/Jimmunol.178.9.5563 |
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| 2007 |
Keir ME, Francisco LM, Sharpe AH. PD-1 and its ligands in T-cell immunity. Current Opinion in Immunology. 19: 309-14. PMID 17433872 DOI: 10.1016/J.Coi.2007.04.012 |
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| 2007 |
Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nature Immunology. 8: 239-45. PMID 17304234 DOI: 10.1038/Ni1443 |
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| 2006 |
Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum JL, Sharpe AH, Lichtman AH. Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation. 114: 2047-55. PMID 17060381 DOI: 10.1161/Circulationaha.106.633263 |
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| 2006 |
Kim G, Schoenberger SP, Sharpe A, Kronenberg M. Synergistic Costimulation by Both B7 Molecules Regulates Colitis Pathogenesis Annals of the New York Academy of Sciences. 1072: 233-241. PMID 17057203 DOI: 10.1196/Annals.1326.012 |
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| 2006 |
Freeman GJ, Wherry EJ, Ahmed R, Sharpe AH. Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. The Journal of Experimental Medicine. 203: 2223-7. PMID 17000870 DOI: 10.1084/Jem.20061800 |
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| 2006 |
Read S, Greenwald R, Izcue A, Robinson N, Mandelbrot D, Francisco L, Sharpe AH, Powrie F. Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. Journal of Immunology (Baltimore, Md. : 1950). 177: 4376-83. PMID 16982872 DOI: 10.4049/Jimmunol.177.7.4376 |
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| 2006 |
Sharpe AH, Abbas AK. T-cell costimulation--biology, therapeutic potential, and challenges. The New England Journal of Medicine. 355: 973-5. PMID 16908487 DOI: 10.1056/Nejmp068087 |
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| 2006 |
Keir ME, Liang SC, Guleria I, Latchman YE, Qipo A, Albacker LA, Koulmanda M, Freeman GJ, Sayegh MH, Sharpe AH. Tissue expression of PD-L1 mediates peripheral T cell tolerance. The Journal of Experimental Medicine. 203: 883-95. PMID 16606670 DOI: 10.1084/Jem.20051776 |
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| 2006 |
Abadía–Molina AC, Ji H, Faubion WA, Julien A, Latchman Y, Yagita H, Sharpe A, Bhan AK, Terhorst C. CD48 controls T-cell and antigen-presenting cell functions in experimental colitis. Gastroenterology. 130: 424-434. PMID 16472597 DOI: 10.1053/J.Gastro.2005.12.009 |
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| 2006 |
Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, Freeman GJ, Ahmed R. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 439: 682-7. PMID 16382236 DOI: 10.1038/Nature04444 |
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| 2006 |
Liang SC, Greenwald RJ, Latchman YE, Rosas L, Satoskar A, Freeman GJ, Sharpe AH. PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis. European Journal of Immunology. 36: 58-64. PMID 16358363 DOI: 10.1002/Eji.200535458 |
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| 2006 |
Zeller GC, Hirahashi J, Schwarting A, Sharpe AH, Kelley VR. Inducible co-stimulator null MRL-Faslpr mice: uncoupling of autoantibodies and T cell responses in lupus. Journal of the American Society of Nephrology : Jasn. 17: 122-30. PMID 16291836 DOI: 10.1681/Asn.2005080802 |
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| 2006 |
Lee KM, Forman JP, McNerney ME, Stepp S, Kuppireddi S, Guzior D, Latchman YE, Sayegh MH, Yagita H, Park CK, Oh SB, Wülfing C, Schatzle J, Mathew PA, Sharpe AH, et al. Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions. Blood. 107: 3181-8. PMID 15905190 DOI: 10.1182/Blood-2005-01-0185 |
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| 2006 |
Francisco L, Brown K, Keir M, Sharpe A. Sa.7. Distinct Roles for Pd-L1 and Pd-L2 in Regulating Host Immunity in EAE Clinical Immunology. 119: S107. DOI: 10.1016/J.Clim.2006.04.239 |
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| 2005 |
Keir ME, Latchman YE, Freeman GJ, Sharpe AH. Programmed death-1 (PD-1):PD-ligand 1 interactions inhibit TCR-mediated positive selection of thymocytes. Journal of Immunology (Baltimore, Md. : 1950). 175: 7372-9. PMID 16301644 DOI: 10.4049/Jimmunol.175.11.7372 |
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| 2005 |
Miyamoto K, Kingsley CI, Zhang X, Jabs C, Izikson L, Sobel RA, Weiner HL, Kuchroo VK, Sharpe AH. The ICOS molecule plays a crucial role in the development of mucosal tolerance. Journal of Immunology (Baltimore, Md. : 1950). 175: 7341-7. PMID 16301640 DOI: 10.4049/Jimmunol.175.11.7341 |
0.487 |
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| 2005 |
Ruiz-Perez B, Chung DR, Sharpe AH, Yagita H, Kalka-Moll WM, Sayegh MH, Kasper DL, Tzianabos AO. Modulation of surgical fibrosis by microbial zwitterionic polysaccharides. Proceedings of the National Academy of Sciences of the United States of America. 102: 16753-8. PMID 16275921 DOI: 10.1073/Pnas.0505688102 |
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| 2005 |
Li L, Greenwald RJ, Lafuente EM, Tzachanis D, Berezovskaya A, Freeman GJ, Sharpe AH, Boussiotis VA. Rap1-GTP is a negative regulator of Th cell function and promotes the generation of CD4+CD103+ regulatory T cells in vivo. Journal of Immunology (Baltimore, Md. : 1950). 175: 3133-9. PMID 16116203 DOI: 10.4049/Jimmunol.175.5.3133 |
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| 2005 |
Van Berkel MEAT, Schrijver EHR, Hofhuis FMA, Sharpe AH, Coyle AJ, Broeren CP, Tesselaar K, Oosterwegel MA. ICOS contributes to T cell expansion in CTLA-4 deficient mice Journal of Immunology. 175: 182-188. PMID 15972646 DOI: 10.4049/Jimmunol.175.1.182 |
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| 2005 |
Ito T, Ueno T, Clarkson MR, Yuan X, Jurewicz MM, Yagita H, Azuma M, Sharpe AH, Auchincloss H, Sayegh MH, Najafian N. Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8 T cell-mediated alloimmune responses in vivo. Journal of Immunology (Baltimore, Md. : 1950). 174: 6648-56. PMID 15905503 DOI: 10.4049/Jimmunol.174.11.6648 |
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| 2005 |
Loser K, Scherer A, Krummen MBW, Varga G, Higuchi T, Schwarz T, Sharpe AH, Grabbe S, Bluestone JA, Beissert S. An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice Journal of Immunology. 174: 5298-5305. PMID 15843526 DOI: 10.4049/Jimmunol.174.9.5298 |
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| 2005 |
Keir ME, Sharpe AH. The B7/CD28 costimulatory family in autoimmunity Immunological Reviews. 204: 128-143. PMID 15790355 DOI: 10.1111/J.0105-2896.2005.00242.X |
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| 2005 |
Greenwald RJ, Freeman GJ, Sharpe AH. The B7 family revisited Annual Review of Immunology. 23: 515-548. PMID 15771580 DOI: 10.1146/Annurev.Immunol.23.021704.115611 |
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| 2005 |
Abbas AK, Sharpe AH. Dendritic cells giveth and taketh away. Nature Immunology. 6: 227-8. PMID 15716967 DOI: 10.1038/Ni0305-227 |
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| 2005 |
Yamada A, Salama AD, Sho M, Najafian N, Ito T, Forman JP, Kewalramani R, Sandner S, Harada H, Clarkson MR, Mandelbrot DA, Sharpe AH, Oshima H, Yagita H, Chalasani G, et al. CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo. Journal of Immunology (Baltimore, Md. : 1950). 174: 1357-64. PMID 15661893 DOI: 10.4049/Jimmunol.174.3.1357 |
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| 2005 |
Kang MS, Lu H, Yasui T, Sharpe A, Warren H, Cahir-McFarland E, Bronson R, Hung SC, Kieff E. Epstein-Barr virus nuclear antigen 1 does not induce lymphoma in transgenic FVB mice. Proceedings of the National Academy of Sciences of the United States of America. 102: 820-5. PMID 15640350 DOI: 10.1073/Pnas.0408774102 |
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| 2005 |
Taylor PA, Panoskaltsis-Mortari A, Freeman GJ, Sharpe AH, Noelle RJ, Rudensky AY, Mak TW, Serody JS, Blazar BR. Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM). Blood. 105: 3372-80. PMID 15618467 DOI: 10.1182/Blood-2004-10-3869 |
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| 2004 |
Dawicki W, Bertram EM, Sharpe AH, Watts TH. 4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses. Journal of Immunology (Baltimore, Md. : 1950). 173: 5944-51. PMID 15528328 DOI: 10.4049/Jimmunol.173.10.5944 |
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Ansel KM, Greenwald RJ, Agarwal S, Bassing CH, Monticelli S, Interlandi J, Djuretic IM, Lee DU, Sharpe AH, Alt FW, Rao A. Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity. Nature Immunology. 5: 1251-9. PMID 15516924 DOI: 10.1038/Ni1135 |
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| 2004 |
Kishimoto K, Yuan X, Auchincloss H, Sharpe AH, Mandelbrot DA, Sayegh MH. Mechanism of action of donor-specific transfusion in inducing tolerance: Role of donor MHC molecules, donor co-stimulatory molecules, and indirect antigen presentation Journal of the American Society of Nephrology. 15: 2423-2428. PMID 15339991 DOI: 10.1097/01.Asn.0000137883.20961.2D |
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| 2004 |
Latchman YE, Liang SC, Wu Y, Chernova T, Sobel RA, Klemm M, Kuchroo VK, Freeman GJ, Sharpe AH. PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 10691-6. PMID 15249675 DOI: 10.1073/Pnas.0307252101 |
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| 2004 |
Reiser J, von Gersdorff G, Loos M, Oh J, Asanuma K, Giardino L, Rastaldi MP, Calvaresi N, Watanabe H, Schwarz K, Faul C, Kretzler M, Davidson A, Sugimoto H, Kalluri R, ... Sharpe AH, et al. Induction of B7-1 in podocytes is associated with nephrotic syndrome. The Journal of Clinical Investigation. 113: 1390-7. PMID 15146236 DOI: 10.1172/Jci20402 |
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| 2004 |
Vijayakrishnan L, Slavik JM, Illés Z, Greenwald RJ, Rainbow D, Greve B, Peterson LB, Hafler DA, Freeman GJ, Sharpe AH, Wicker LS, Kuchroo VK. An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Immunity. 20: 563-75. PMID 15142525 DOI: 10.1016/S1074-7613(04)00110-4 |
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| 2004 |
Wang N, Satoskar A, Faubion W, Howie D, Okamoto S, Feske S, Gullo C, Clarke K, Sosa MR, Sharpe AH, Terhorst C. The cell surface receptor SLAM controls T cell and macrophage functions. The Journal of Experimental Medicine. 199: 1255-64. PMID 15123745 DOI: 10.1084/Jem.20031835 |
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| 2004 |
Buono C, Pang H, Uchida Y, Libby P, Sharpe AH, Lichtman AH. B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice. Circulation. 109: 2009-15. PMID 15096453 DOI: 10.1161/01.Cir.0000127121.16815.F1 |
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Taylor PA, Lees CJ, Fournier S, Allison JP, Sharpe AH, Blazar BR. B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions Journal of Immunology. 172: 34-39. PMID 14688306 DOI: 10.4049/Jimmunol.172.1.34 |
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Taylor P, Panoskaltsis-Mortari A, Freeman G, Sharpe A, Noelle R, Rudensky A, Mak T, Serody J, Blazar B. The ICOS:ICOSL Costimulatory Pathway Plays an Important Role in GVHD and Bone Marrow (BM) Graft Rejection. Blood. 104: 591-591. DOI: 10.1182/Blood.V104.11.591.591 |
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Li L, Greenwald R, Lafuente EM, Tzachanis D, Berezovskaya A, Freeman GJ, Sharpe AH, Boussiotis VA. Rap1-GTP Promotes the Generation of Regulatory T Cells in Vivo. Blood. 104: 110-110. DOI: 10.1182/Blood.V104.11.110.110 |
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| 2003 |
Martin-Orozco N, Chen Z, Poirot L, Hyatt E, Chen A, Kanagawa O, Sharpe A, Mathis D, Benoist C. Paradoxical dampening of anti-islet self-reactivity but promotion of diabetes by OX40 ligand. Journal of Immunology (Baltimore, Md. : 1950). 171: 6954-60. PMID 14662903 DOI: 10.4049/Jimmunol.171.12.6954 |
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| 2003 |
Ariyan C, Salvalaggio P, Fecteau S, Deng S, Rogozinski L, Mandelbrot D, Sharpe A, Sayegh MH, Basadonna GP, Rothstein DM. Cutting edge: transplantation tolerance through enhanced CTLA-4 expression. Journal of Immunology (Baltimore, Md. : 1950). 171: 5673-7. PMID 14634073 DOI: 10.4049/Jimmunol.171.11.5673 |
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| 2003 |
Rodig N, Ryan T, Allen JA, Pang H, Grabie N, Chernova T, Greenfield EA, Liang SC, Sharpe AH, Lichtman AH, Freeman GJ. Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis. European Journal of Immunology. 33: 3117-26. PMID 14579280 DOI: 10.1002/Eji.200324270 |
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| 2003 |
Liang SC, Latchman YE, Buhlmann JE, Tomczak MF, Horwitz BH, Freeman GJ, Sharpe AH. Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses. European Journal of Immunology. 33: 2706-16. PMID 14515254 DOI: 10.1002/Eji.200324228 |
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| 2003 |
Ryeom S, Greenwald RJ, Sharpe AH, McKeon F. The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin. Nature Immunology. 4: 874-81. PMID 12925851 DOI: 10.1038/Ni966 |
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| 2003 |
Chang TT, Sobel RA, Wei T, Ransohoff RM, Kuchroo VK, Sharpe AH. Recovery from EAE is associated with decreased survival of encephalitogenic T cells in the CNS of B7-1/B7-2-deficient mice. European Journal of Immunology. 33: 2022-2032. PMID 12884869 DOI: 10.1002/Eji.200323180 |
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Harada H, Salama AD, Sho M, Izawa A, Sandner SE, Ito T, Akiba H, Yagita H, Sharpe AH, Freeman GJ, Sayegh MH. The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity. The Journal of Clinical Investigation. 112: 234-43. PMID 12865411 DOI: 10.1172/Jci17008 |
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Lohr J, Knoechel B, Jiang S, Sharpe AH, Abbas AK. The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens. Nature Immunology. 4: 664-9. PMID 12766766 DOI: 10.1038/Ni939 |
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| 2003 |
Buhlmann JE, Elkin SK, Sharpe AH. A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection Journal of Immunology. 170: 5421-5428. PMID 12759417 DOI: 10.4049/Jimmunol.170.11.5421 |
0.431 |
|
| 2003 |
Blazar BR, Sharpe AH, Chen AI, Panoskaltsis-Mortari A, Lees C, Akiba H, Yagita H, Killeen N, Taylor PA. Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipients. Blood. 101: 3741-8. PMID 12521997 DOI: 10.1182/Blood-2002-10-3048 |
0.496 |
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| 2003 |
Ekkens MJ, Liu Z, Liu Q, Whitmire J, Xiao S, Foster A, Pesce J, VanNoy J, Sharpe AH, Urban JF, Gause WC. The role of OX40 ligand interactions in the development of the Th2 response to the gastrointestinal nematode parasite Heligmosomoides polygyrus. Journal of Immunology (Baltimore, Md. : 1950). 170: 384-93. PMID 12496423 DOI: 10.4049/Jimmunol.170.1.384 |
0.418 |
|
| 2002 |
Liu Z, Liu Q, Pesce J, Whitmire J, Ekkens MJ, Foster A, VanNoy J, Sharpe AH, Urban JF, Gause WC. Nippostrongylus brasiliensis can induce B7-independent antigen-specific development of IL-4-producing T cells from naive CD4 T cells in vivo. Journal of Immunology (Baltimore, Md. : 1950). 169: 6959-68. PMID 12471130 DOI: 10.4049/Jimmunol.169.12.6959 |
0.536 |
|
| 2002 |
Montagnoli C, Bacci A, Bozza S, Gaziano R, Mosci P, Sharpe AH, Romani L. B7/CD28-dependent CD4+CD25+ regulatory T cells are essential components of the memory-protective immunity to Candida albicans. Journal of Immunology (Baltimore, Md. : 1950). 169: 6298-308. PMID 12444136 DOI: 10.4049/Jimmunol.169.11.6298 |
0.474 |
|
| 2002 |
Green KA, Cook WJ, Sharpe AH, Green WR. The CD154/CD40 interaction required for retrovirus-induced murine immunodeficiency syndrome is not mediated by upregulation of the CD80/CD86 costimulatory molecules. Journal of Virology. 76: 13106-10. PMID 12438641 DOI: 10.1128/Jvi.76.24.13106-13110.2002 |
0.361 |
|
| 2002 |
Prilliman KR, Lemmens EE, Palioungas G, Wolfe TG, Allison JP, Sharpe AH, Schoenberger SP. Cutting edge: A crucial role for B7-CD28 in transmitting T help from APC to CTL Journal of Immunology. 169: 4094-4097. PMID 12370335 DOI: 10.4049/Jimmunol.169.8.4094 |
0.404 |
|
| 2002 |
Arestides RS, He H, Westlake RM, Chen AI, Sharpe AH, Perkins DL, Finn PW. Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation. European Journal of Immunology. 32: 2874-80. PMID 12355440 DOI: 10.1002/1521-4141(2002010)32:10<2874::Aid-Immu2874>3.0.Co;2-4 |
0.406 |
|
| 2002 |
Schneider H, Mandelbrot DA, Greenwald RJ, Ng F, Lechler R, Sharpe AH, Rudd CE. Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice Journal of Immunology. 169: 3475-3479. PMID 12244135 DOI: 10.4049/Jimmunol.169.7.3475 |
0.425 |
|
| 2002 |
Mencacci A, Montagnoli C, Bacci A, Cenci E, Pitzurra L, Spreca A, Kopf M, Sharpe AH, Romani L. CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis. Journal of Immunology (Baltimore, Md. : 1950). 169: 3180-90. PMID 12218136 DOI: 10.4049/Jimmunol.169.6.3180 |
0.425 |
|
| 2002 |
Jabs C, Greve B, Chang TT, Sobel RA, Sharpe AH, Kuchroo VK. Genetic background determines the requirement for B7 costimulation in induction of autoimmunity. European Journal of Immunology. 32: 2687-97. PMID 12207354 DOI: 10.1002/1521-4141(200209)32:9<2687::Aid-Immu2687>3.0.Co;2-1 |
0.542 |
|
| 2002 |
Martin M, Sharpe A, Clements JD, Michalek SM. Role of B7 costimulatory molecules in the adjuvant activity of the heat-labile enterotoxin of Escherichia coli. Journal of Immunology (Baltimore, Md. : 1950). 169: 1744-52. PMID 12165495 DOI: 10.4049/Jimmunol.169.4.1744 |
0.417 |
|
| 2002 |
Freeman GJ, Sharpe AH, Kuchroo VK. Protect the killer: CTLS need defenses against the tumor Nature Medicine. 8: 787-789. PMID 12152031 DOI: 10.1038/Nm0802-787 |
0.409 |
|
| 2002 |
Akbari O, Freeman GJ, Meyer EH, Greenfield EA, Chang TT, Sharpe AH, Berry G, DeKruyff RH, Umetsu DT. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nature Medicine. 8: 1024-32. PMID 12145647 DOI: 10.1038/Nm745 |
0.629 |
|
| 2002 |
Brown JA, Greenwald RJ, Scott S, Schweitzer AN, Satoskar AR, Chung C, Schopf LR, van der Woude D, Sypek JP, Sharpe AH. T helper differentiation in resistant and susceptible B7-deficient mice infected with Leishmania major. European Journal of Immunology. 32: 1764-72. PMID 12115660 DOI: 10.1002/1521-4141(200206)32:6<1764::Aid-Immu1764>3.0.Co;2-V |
0.399 |
|
| 2002 |
Ekkens MJ, Liu Z, Liu Q, Foster A, Whitmire J, Pesce J, Sharpe AH, Urban JF, Gause WC. Memory Th2 effector cells can develop in the absence of B7-1/B7-2, CD28 interactions, and effector Th cells after priming with an intestinal nematode parasite. Journal of Immunology (Baltimore, Md. : 1950). 168: 6344-51. PMID 12055251 DOI: 10.4049/Jimmunol.168.12.6344 |
0.412 |
|
| 2002 |
Greenwald RJ, Latchman YE, Sharpe AH. Negative co-receptors on lymphocytes Current Opinion in Immunology. 14: 391-396. PMID 11973140 DOI: 10.1016/S0952-7915(02)00341-2 |
0.527 |
|
| 2002 |
Sharpe AH, Freeman GJ. The B7-CD28 superfamily Nature Reviews Immunology. 2: 116-126. PMID 11910893 DOI: 10.1038/Nri727 |
0.485 |
|
| 2002 |
Chang TT, Kuchroo VK, Sharpe AH. Role of the B7-CD28/CTLA-4 pathway in autoimmune disease. Current Directions in Autoimmunity. 5: 113-30. PMID 11826754 DOI: 10.1159/000060550 |
0.558 |
|
| 2002 |
Greenwald RJ, Oosterwegel MA, Van Der Woude D, Kubal A, Mandelbrot DA, Boussiotis VA, Sharpe AH. CTLA-4 regulates cell cycle progression during a primary immune response European Journal of Immunology. 32: 366-373. PMID 11807776 DOI: 10.1002/1521-4141(200202)32:2<366::Aid-Immu366>3.0.Co;2-5 |
0.473 |
|
| 2002 |
Greenwald RJ, McAdam AJ, Van der Woude D, Satoskar AR, Sharpe AH. Cutting edge: Inducible costimulator protein regulates both Th1 and Th2 responses to cutaneous Leishmaniasis Journal of Immunology. 168: 991-995. PMID 11801630 DOI: 10.4049/Jimmunol.168.3.991 |
0.387 |
|
| 2001 |
Mandelbrot DA, Kishimoto K, Auchincloss H. J, Sharpe AH, Sayegh MH. Rejection of mouse cardiac allografts by costimulation in trans Journal of Immunology. 167: 1174-1178. PMID 11466331 DOI: 10.4049/Jimmunol.167.3.1174 |
0.48 |
|
| 2001 |
Yamada A, Kishimoto K, Dong VM, Sho M, Salama AD, Anosova NG, Benichou G, Mandelbrot DA, Sharpe AH, Turka LA, Auchincloss H, Sayegh MH. CD28-independent costimulation of T cells in alloimmune responses. Journal of Immunology (Baltimore, Md. : 1950). 167: 140-6. PMID 11418642 DOI: 10.4049/Jimmunol.167.1.140 |
0.474 |
|
| 2001 |
McAdam AJ, Greenwald RJ, Levin MA, Chernova T, Malenkovich N, Ling V, Freeman GJ, Sharpe AH. ICOS is critical for CD40-mediated antibody class switching. Nature. 409: 102-5. PMID 11343122 DOI: 10.1038/35051107 |
0.525 |
|
| 2001 |
Wu C, Nguyen KB, Pien GC, Wang N, Gullo C, Howie D, Sosa MR, Edwards MJ, Borrow P, Satoskar AR, Sharpe AH, Biron CA, Terhorst C. SAP controls T cell responses to virus and terminal differentiation of TH2 cells. Nature Immunology. 2: 410-4. PMID 11323694 DOI: 10.1038/87713 |
0.515 |
|
| 2001 |
Mandelbrot DA, Oosterwegel MA, Shimizu K, Yamada A, Freeman GJ, Mitchell RN, Sayegh MH, Sharpe AH. B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4. The Journal of Clinical Investigation. 107: 881-7. PMID 11285307 DOI: 10.1172/Jci11710 |
0.505 |
|
| 2001 |
Witke W, Sutherland JD, Sharpe A, Arai M, Kwiatkowski DJ. Profilin I is essential for cell survival and cell division in early mouse development. Proceedings of the National Academy of Sciences of the United States of America. 98: 3832-6. PMID 11274401 DOI: 10.1073/Pnas.051515498 |
0.35 |
|
| 2001 |
Greenwald RJ, Boussiotis VA, Lorsbach RB, Abbas AK, Sharpe AH. CTLA-4 regulates induction of anergy in vivo Immunity. 14: 145-155. PMID 11239447 DOI: 10.1016/S1074-7613(01)00097-8 |
0.496 |
|
| 2001 |
Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, ... ... Sharpe AH, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nature Immunology. 2: 261-8. PMID 11224527 DOI: 10.1038/85330 |
0.446 |
|
| 2000 |
Santra S, Barouch DH, Jackson SS, Kuroda MJ, Schmitz JE, Lifton MA, Sharpe AH, Letvin NL. Functional equivalency of B7-1 and B7-2 for costimulating plasmid DNA vaccine-elicited CTL responses. Journal of Immunology (Baltimore, Md. : 1950). 165: 6791-5. PMID 11120800 DOI: 10.4049/Jimmunol.165.12.6791 |
0.347 |
|
| 2000 |
Gaglia JL, Greenfield EA, Mattoo A, Sharpe AH, Freeman GJ, Kuchroo VK. Intercellular adhesion molecule 1 is critical for activation of CD28-deficient T cells Journal of Immunology. 165: 6091-6098. PMID 11086041 DOI: 10.4049/Jimmunol.165.11.6091 |
0.495 |
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| 2000 |
McAdam AJ, Chang TT, Lumelsky AE, Greenfield EA, Boussiotis VA, Duke-Cohan JS, Chernova T, Malenkovich N, Jabs C, Kuchroo VK, Ling V, Collins M, Sharpe AH, Freeman GJ. Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 165: 5035-40. PMID 11046032 DOI: 10.4049/Jimmunol.165.9.5035 |
0.622 |
|
| 2000 |
Santra S, Barouch DH, Sharpe AH, Letvin NL. B7 co-stimulatory requirements differ for induction of immune responses by DNA, protein and recombinant pox virus vaccination European Journal of Immunology. 30: 2650-2659. PMID 11009099 DOI: 10.1002/1521-4141(200009)30:9<2650::Aid-Immu2650>3.0.Co;2-K |
0.366 |
|
| 2000 |
Liang B, Kashgarian MJ, Sharpe AH, Mamula MJ. Autoantibody responses and pathology regulated by B7-1 and B7-2 costimulation in MRL/lpr lupus Journal of Immunology. 165: 3436-3443. PMID 10975864 DOI: 10.4049/Jimmunol.165.6.3436 |
0.392 |
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| 2000 |
McAdam AJ, Gewurz BE, Farkash EA, Sharpe AH. Either B7 costimulation or IL-2 can elicit generation of primary alloreactive CTL Journal of Immunology. 165: 3088-3093. PMID 10975820 DOI: 10.4049/Jimmunol.165.6.3088 |
0.417 |
|
| 2000 |
Furukawa Y, Mandelbrot DA, Libby P, Sharpe AH, Mitchell RN. Association of B7-1 co-stimulation with the development of graft arterial disease. Studies using mice lacking B7-1, B7-2, or B7-1/B7-2. The American Journal of Pathology. 157: 473-84. PMID 10934151 DOI: 10.1016/S0002-9440(10)64559-2 |
0.324 |
|
| 2000 |
Kasprowicz DJ, Kohm AP, Berton MT, Chruscinski AJ, Sharpe A, Sanders VM. Stimulation of the B cell receptor, CD86 (B7-2), and the beta 2-adrenergic receptor intrinsically modulates the level of IgG1 and IgE produced per B cell. Journal of Immunology (Baltimore, Md. : 1950). 165: 680-90. PMID 10878340 DOI: 10.4049/Jimmunol.165.2.680 |
0.406 |
|
| 2000 |
Kinoshita K, Tesch G, Schwarting A, Maron R, Sharpe AH, Kelley VR. Costimulation by B7-1 and B7-2 is required for autoimmune disease in MRL-Fas(lpr) mice Journal of Immunology. 164: 6046-6056. PMID 10820290 DOI: 10.4049/Jimmunol.164.11.6046 |
0.361 |
|
| 2000 |
Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 12: 431-440. PMID 10795741 DOI: 10.1016/S1074-7613(00)80195-8 |
0.449 |
|
| 2000 |
Yu X, Fournier S, Allison JP, Sharpe AH, Hodes RJ. The role of B7 costimulation in CD4/CD8 T cell homeostasis Journal of Immunology. 164: 3543-3553. PMID 10725709 DOI: 10.4049/Jimmunol.164.7.3543 |
0.499 |
|
| 2000 |
Mark DA, Donovan CE, De Sanctis GT, He HZ, Cernadas M, Kobzik L, Perkins DL, Sharpe A, Finn PW. B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness. American Journal of Respiratory Cell and Molecular Biology. 22: 265-71. PMID 10696062 DOI: 10.1165/Ajrcmb.22.3.3747 |
0.358 |
|
| 2000 |
Qian J, Collins M, Sharpe AH, Hoyer LW. Prevention and treatment of factor VIII inhibitors in murine hemophilia A Blood. 95: 1324-1329. PMID 10666206 DOI: 10.1182/Blood.V95.4.1324.004K25_1324_1329 |
0.424 |
|
| 2000 |
Girvin AM, Dal Canto MC, Rhee L, Salomon B, Sharpe A, Bluestone JA, Miller SD. A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade. Journal of Immunology (Baltimore, Md. : 1950). 164: 136-43. PMID 10605004 DOI: 10.4049/Jimmunol.164.1.136 |
0.467 |
|
| 2000 |
McAdam AJ, Farkash EA, Gewurz BE, Sharpe AH. B7 costimulation is critical for antibody class switching and CD8+ cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus Journal of Virology. 74: 203-208. PMID 10590107 DOI: 10.1128/Jvi.74.1.203-208.2000 |
0.447 |
|
| 2000 |
Guo Z, Meng L, Kim O, He G, Szot GL, Hart J, Wang J, Collins M, Thistlethwaite JR, Sharpe AH, Bluestone JA, Newell KA. DIFFERENT EFFECTS OF VARIOUS STRATEGIES FOR BLOCKING CD28/B7 INTERACTIONS ON INTESTINAL ALLOGRAFT REJECTION. Transplantation. 69: S416-S417. DOI: 10.1097/00007890-200004271-01165 |
0.33 |
|
| 1999 |
Anderson DE, Sharpe AH, Hafler DA. The B7-CD28/CTLA-4 costimulatory pathways in autoimmune disease of the central nervous system. Current Opinion in Immunology. 11: 677-83. PMID 10631554 DOI: 10.1016/S0952-7915(99)00036-9 |
0.482 |
|
| 1999 |
Chen AI, McAdam AJ, Buhlmann JE, Scott S, Lupher ML, Greenfield EA, Baum PR, Fanslow WC, Calderhead DM, Freeman GJ, Sharpe AH. Ox40-ligand has a critical costimulatory role in dendritic cell:T cell interactions. Immunity. 11: 689-98. PMID 10626891 DOI: 10.1016/S1074-7613(00)80143-0 |
0.528 |
|
| 1999 |
Abbas AK, Sharpe AH. T-cell stimulation: An abundance of B7s Nature Medicine. 5: 1345-1346. PMID 10581066 DOI: 10.1038/70905 |
0.451 |
|
| 1999 |
Guttormsen HK, Sharpe AH, Chandraker AK, Brigtsen AK, Sayegh MH, Kasper DL. Cognate stimulatory B-cell-T-cell interactions are critical for T-cell help recruited by glycoconjugate vaccines Infection and Immunity. 67: 6375-6384. PMID 10569753 DOI: 10.1128/Iai.67.12.6375-6384.1999 |
0.508 |
|
| 1999 |
Schweitzer AN, Sharpe AH. Mutual regulation between B7-1 (CD80) expressed on T cells and IL-4 Journal of Immunology. 163: 4819-4825. PMID 10528182 |
0.341 |
|
| 1999 |
Ling V, Wu PW, Finnerty HF, Sharpe AH, Gray GS, Collins M. Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders. Genomics. 60: 341-55. PMID 10493833 DOI: 10.1006/Geno.1999.5930 |
0.339 |
|
| 1999 |
Chang TT, Jabs C, Sobel RA, Kuchroo VK, Sharpe AH. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. The Journal of Experimental Medicine. 190: 733-40. PMID 10477557 DOI: 10.1084/Jem.190.5.733 |
0.63 |
|
| 1999 |
Humphries DE, Wong GW, Friend DS, Gurish MF, Qiu WT, Huang C, Sharpe AH, Stevens RL. Heparin is essential for the storage of specific granule proteases in mast cells. Nature. 400: 769-72. PMID 10466726 DOI: 10.1038/23481 |
0.382 |
|
| 1999 |
Oosterwegel MA, Mandelbrot DA, Boyd SD, Lorsbach RB, Jarrett DY, Abbas AK, Sharpe AH. The role of CTLA-4 in regulating Th2 differentiation. Journal of Immunology (Baltimore, Md. : 1950). 163: 2634-9. PMID 10453003 |
0.411 |
|
| 1999 |
Lynch WP, Sharpe AH, Snyder EY. Neural stem cells as engraftable packaging lines can mediate gene delivery to microglia: evidence from studying retroviral env-related neurodegeneration. Journal of Virology. 73: 6841-51. PMID 10400782 DOI: 10.1128/Jvi.73.8.6841-6851.1999 |
0.32 |
|
| 1999 |
Oosterwegel MA, Greenwald RJ, Mandelbrot DA, Lorsbach RB, Sharpe AH. CTLA-4 and T cell activation. Current Opinion in Immunology. 11: 294-300. PMID 10375557 DOI: 10.1016/S0952-7915(99)80047-8 |
0.52 |
|
| 1999 |
Blazar BR, Taylor PA, Panoskaltsis-Mortari A, Sharpe AH, Vallera DA. Opposing roles of CD28:B7 and CTLA-4:B7 pathways in regulating in vivo alloresponses in murine recipients of MHC disparate T cells Journal of Immunology. 162: 6368-6377. PMID 10352249 |
0.395 |
|
| 1999 |
Khattri R, Auger JA, Griffin MD, Sharpe AH, Bluestone JA. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses Journal of Immunology. 162: 5784-5791. PMID 10229811 |
0.411 |
|
| 1999 |
La Motte RN, Sharpe AH, Bluestone JA, Mokyr MB. Host B7-1 and B7-2 costimulatory molecules contribute to the eradication of B7-1-transfected P815 tumor cells via a CD8+ T cell-dependent mechanism. Journal of Immunology (Baltimore, Md. : 1950). 162: 4817-23. PMID 10202025 |
0.322 |
|
| 1999 |
Hernandez HJ, Sharpe AH, Stadecker MJ. Experimental murine schistosomiasis in the absence of B7 costimulatory molecules: Reversal of elicited T cell cytokine profile and partial inhibition of egg granuloma formation Journal of Immunology. 162: 2884-2889. PMID 10072537 |
0.41 |
|
| 1999 |
González-Cabrero J, Wise CJ, Latchman Y, Freeman GJ, Sharpe AH, Reiser H. CD48-deficient mice have a pronounced defect in CD4+ T cell activation Proceedings of the National Academy of Sciences of the United States of America. 96: 1019-1023. PMID 9927686 DOI: 10.1073/Pnas.96.3.1019 |
0.505 |
|
| 1999 |
Mandelbrot DA, McAdam AJ, Sharpe AH. B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) Journal of Experimental Medicine. 189: 435-440. PMID 9892625 DOI: 10.1084/Jem.189.2.435 |
0.464 |
|
| 1999 |
Guttormsen H, Sharpe AH, Chandraker AK, Brigtsen AK, Sayegh MH, Kasper DL. Cognate Stimulatory B-Cell–T-Cell Interactions Are Critical for T-Cell Help Recruited by Glycoconjugate Vaccines Infection and Immunity. 67: 6375-6384. DOI: 10.1128/iai.67.12.6375-6384.1999 |
0.376 |
|
| 1999 |
Judge TA, Sayegh MH, Wu Z, Zheng X, Sharpe A, Turka LA. THE ROLE OF CTLA4-MEDIATED NEGATIVE SIGNALS AND CELL SURVIVAL IN TOLERANCE INDUCTION BY BLOCKADE OF B7:CD28 AND CD40:CD40L (CD154). Transplantation. 67: S235. DOI: 10.1097/00007890-199904150-00939 |
0.373 |
|
| 1999 |
Mandelbrot DA, Furukawa Y, McAdam AJ, Alexander SI, Libby P, Mitchell RN, Sharpe AH. HEART TRANSPLANTATION USING MICE LACKING B7-1 AND B7-2 DEMONSTRATES THAT GRAFT SURVIVAL IS DETERMINED BY EXPRESSION OF B7 MOLECULES ON RECIPIENT, NOT DONOR CELLS. Transplantation. 67: S119. DOI: 10.1097/00007890-199904150-00479 |
0.321 |
|
| 1998 |
Rauschmayr-Kopp T, Williams IR, Borriello F, Sharpe AH, Kupper TS. Distinct roles for B7 costimulation in contact hypersensitivity and humoral immune responses to epicutaneous antigen European Journal of Immunology. 28: 4221-4227. PMID 9862359 DOI: 10.1002/(Sici)1521-4141(199812)28:12<4221::Aid-Immu4221>3.0.Co;2-M |
0.406 |
|
| 1998 |
McAdam AJ, Schweitzer AN, Sharpe AH. The role of B7 co-stimulation in activation and differentiation of CD4+ and CD8+ T cells Immunological Reviews. 165: 231-247. PMID 9850864 DOI: 10.1111/J.1600-065X.1998.Tb01242.X |
0.502 |
|
| 1998 |
Wang B, Wang N, Salio M, Sharpe A, Allen D, She J, Terhorst C. Essential and Partially Overlapping Role of CD3γ and CD3δ for Development of αβ and γδ T Lymphocytes Journal of Experimental Medicine. 188: 1375-1380. PMID 9763617 DOI: 10.1084/Jem.188.7.1375 |
0.481 |
|
| 1998 |
Schweitzer AN, Sharpe AH. Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production Journal of Immunology. 161: 2762-2771. PMID 9743334 |
0.359 |
|
| 1998 |
Guttormsen HK, Sayegh MH, Sharpe AH, Wetzler LM, Chandraker AK, Kasper DL. Recruitment of T cell help by a glyco-conjugate vaccine Faseb Journal. 12. |
0.338 |
|
| 1997 |
Van Parijs L, Sethna MP, Schweitzer AN, Borriello F, Sharpe AH, Abbas AK. Functional Consequences of Dysregulated B7-1 (CD80) and B7-2 (CD86) Expression in B or T Lymphocytes of Transgenic Mice Journal of Immunology. 159: 5336-5344. PMID 9548473 |
0.407 |
|
| 1997 |
Schweitzer AN, Sharpe AH. The complexity of the B7-CD28/CTLA-4 costimulatory pathway Agents and Actions Supplements. 49: 33-43. PMID 9426826 |
0.344 |
|
| 1997 |
Tivol EA, Boyd SD, McKeon S, Borriello F, Nickerson P, Strom TB, Sharpe AH. CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 158: 5091-4. PMID 9164923 |
0.322 |
|
| 1997 |
Borriello F, Lederer J, Scott S, Sharpe AH. MRC OX-2 Defines a Novel T Cell Costimulatory Pathway Journal of Immunology. 158: 4548-4554. PMID 9144466 |
0.397 |
|
| 1997 |
Borriello F, Sethna MP, Boyd SD, Schweitzer AN, Tivol EA, Jacoby D, Strom TB, Simpson EM, Freeman GJ, Sharpe AH. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity. 6: 303-13. PMID 9075931 DOI: 10.1016/S1074-7613(00)80333-7 |
0.355 |
|
| 1997 |
Schweitzer AN, Borriello F, Wong RCK, Abbas AK, Sharpe AH. Role of Costimulators in T Cell Differentiation: Studies Using Antigen-Presenting Cells Lacking Expression of CD80 or CD86 Journal of Immunology. 158: 2713-2722. PMID 9058805 |
0.323 |
|
| 1997 |
Yergeau DA, Hetherington CJ, Wang Q, Zhang P, Sharpe AH, Binder M, Marín-Padilla M, Tenen DG, Speck NA, Zhang DE. Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nature Genetics. 15: 303-6. PMID 9054947 DOI: 10.1038/Ng0397-303 |
0.355 |
|
| 1996 |
Tivol EA, Schweitzert AN, Sharpe AH. Costimulation and autoimmunity Current Opinion in Immunology. 8: 822-830. PMID 8994862 DOI: 10.1016/S0952-7915(96)80011-2 |
0.458 |
|
| 1996 |
Coxon A, Rieu P, Barkalow FJ, Askari S, Sharpe AH, Von Andrian UH, Arnaout MA, Mayadas TN. A novel role for the β2 integrin CD11b/CD18 in neutrophil apoptosis: A homeostatic mechanism in inflammation Immunity. 5: 653-666. PMID 8986723 DOI: 10.1016/S1074-7613(00)80278-2 |
0.354 |
|
| 1996 |
Wang JH, Nichogiannopoulou A, Wu L, Sun L, Sharpe AH, Bigby M, Georgopoulos K. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation Immunity. 5: 537-549. PMID 8986714 DOI: 10.1016/S1074-7613(00)80269-1 |
0.445 |
|
| 1996 |
Blazar BR, Sharpe AH, Taylor PA, Panoskaltsis-Mortari A, Gray GS, Korngold R, Vallera DA. Infusion of Anti-B7.1 (CD80) and Anti-B7.2 (CD86) Monoclonal Antibodies Inhibits Murine Graft-Versus-Host Disease Lethality in Part Via Direct Effects on CD4+ and CD8+ T Cells Journal of Immunology. 157: 3250-3259. PMID 8871619 |
0.325 |
|
| 1996 |
Sharpe AH. Costimulatory signals and viral immunity Seminars in Virology. 7: 103-111. DOI: 10.1006/Smvy.1996.0013 |
0.481 |
|
| 1995 |
Witke W, Sharpe AH, Hartwig JH, Azuma T, Stossel TP, Kwiatkowski DJ. Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin Cell. 81: 41-51. PMID 7720072 DOI: 10.1016/0092-8674(95)90369-0 |
0.312 |
|
| 1995 |
Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4 Immunity. 3: 541-547. PMID 7584144 DOI: 10.1016/1074-7613(95)90125-6 |
0.52 |
|
| 1995 |
Sharpe AH. Analysis of lymphocyte costimulation in vivo using transgenic and 'knockout' mice Current Opinion in Immunology. 7: 389-395. PMID 7546405 DOI: 10.1016/0952-7915(95)80115-4 |
0.379 |
|
| 1995 |
Jellis CL, Wang SS, Rennert P, Borriello F, Sharpe AH, Green NR, Gray GS. Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86) Immunogenetics. 42: 85-89. PMID 7541777 DOI: 10.1007/Bf00178582 |
0.417 |
|
| 1995 |
Prabhu Das MR, Zamvil SS, Borriello F, Weiner HL, Sharpe AH, Kuchroo VK. Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation European Journal of Immunology. 25: 207-211. PMID 7531145 DOI: 10.1002/Eji.1830250134 |
0.458 |
|
| 1995 |
Gurtner GC, Davis V, Li H, McCoy MJ, Sharpe A, Cybulsky MI. Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation. Genes & Development. 9: 1-14. PMID 7530222 DOI: 10.1101/Gad.9.1.1 |
0.3 |
|
| 1995 |
Borriello F, Oliveros J, Freeman GJ, Nadler LM, Sharpe AH. Differential expression of alternate mB7-2 transcripts Journal of Immunology. 155: 5490-5497. PMID 7499829 |
0.307 |
|
| 1995 |
Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3 Science. 270: 794-797. PMID 7481767 DOI: 10.1126/Science.270.5237.794 |
0.393 |
|
| 1994 |
Georgopoulos K, Bigby M, Wang JH, Molnar A, Wu P, Winandy S, Sharpe A. The Ikaros gene is required for the development of all lymphoid lineages. Cell. 79: 143-56. PMID 7923373 DOI: 10.1016/0092-8674(94)90407-3 |
0.396 |
|
| 1994 |
Sethna MP, van Perijs L, Sharpe AH, Abbas AK, Freemant GJ. A negative regulatory function of B7 revealed in B7-1 transgenic mice Immunity. 1: 415-421. PMID 7533646 DOI: 10.1016/1074-7613(94)90072-8 |
0.451 |
|
| 1994 |
Borriello F, Freeman GJ, Edelhoff S, Disteche CM, Nadler LM, Sharpe AH. Characterization of the murine B7-1 genomic locus reveals an additional exon encoding an alternative cytoplasmic domain and a chromosomal location of chromosome 16, band B5 Journal of Immunology. 153: 5038-5048. PMID 7525722 |
0.308 |
|
| 1990 |
Sugimoto M, Sharpe AH, Sato Y, Greene MI, Fields BN. Reovirus transport – studies using lymphocytosis promoting factor Pathobiology. 58: 185-192. PMID 2174674 DOI: 10.1159/000163582 |
0.333 |
|
| 1988 |
Sharpe AH, Hunter JJ, Ruprecht RM, Jaenisch R. Maternal transmission of retroviral disease: Transgenic mice as a rapid test system for evaluating potential and transplacental antiretroviral therapy Proceedings of the National Academy of Sciences of the United States of America. 85: 9792-9796. PMID 2849117 DOI: 10.1073/Pnas.85.24.9792 |
0.308 |
|
| 1987 |
Wolf JL, Dambrauskas R, Sharpe AH, Trier JS. Adherence to and penetration of the intestinal epithelium by reovirus type 1 in neonatal mice Gastroenterology. 92: 82-91. PMID 3023169 DOI: 10.1016/0016-5085(87)90842-0 |
0.341 |
|
| 1984 |
Sharpe AH, Gaulton GN, McDade KK, Fields BN, Greene MI. Syngeneic monoclonal antiidiotype can induce cellular immunity to reovirus Journal of Experimental Medicine. 160: 1195-1205. PMID 6332875 DOI: 10.1084/Jem.160.4.1195 |
0.351 |
|
| 1981 |
Ahmed R, Canning WM, Kauffman RS, Sharpe AH, Hallum JV, Fields BN. Role of the host cell in persistent viral infection: Coevolution of L cells and reovirus during persistent infection Cell. 25: 325-332. PMID 7285112 DOI: 10.1016/0092-8674(81)90050-7 |
0.332 |
|
| 1981 |
Wolf JL, Rubin DH, Finberg R, Kauffman RS, Sharpe AH, Trier JS, Fields BN. Intestinal M cells: A pathway for entry of reovirus into the host Science. 212: 471-472. PMID 6259737 DOI: 10.1126/Science.6259737 |
0.323 |
|
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