| Year |
Citation |
Score |
| 2015 |
Topletz AR, Tripathy S, Foti RS, Shimshoni JA, Nelson WL, Isoherranen N. Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids. Molecular Pharmacology. 87: 430-41. PMID 25492813 DOI: 10.1124/Mol.114.096784 |
0.313 |
|
| 2012 |
Peng CC, Shi W, Lutz JD, Kunze KL, Liu JO, Nelson WL, Isoherranen N. Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 426-35. PMID 22106171 DOI: 10.1124/Dmd.111.042739 |
0.352 |
|
| 2011 |
Thatcher JE, Buttrick B, Shaffer SA, Shimshoni JA, Goodlett DR, Nelson WL, Isoherranen N. Substrate specificity and ligand interactions of CYP26A1, the human liver retinoic acid hydroxylase. Molecular Pharmacology. 80: 228-39. PMID 21521770 DOI: 10.1124/Mol.111.072413 |
0.315 |
|
| 2011 |
Babu KN, Kunze KL, Nelson WL. Metabolism of diltiazem: A short efficient synthesis of N, N -didesmethyldiltiazem - An important product of N-demethylation Synthesis. 553-554. DOI: 10.1055/S-0030-1258410 |
0.341 |
|
| 2010 |
Hanson KL, VandenBrink BM, Babu KN, Allen KE, Nelson WL, Kunze KL. Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 963-72. PMID 20200233 DOI: 10.1124/Dmd.110.032391 |
0.326 |
|
| 2006 |
Kunze KL, Nelson WL, Kharasch ED, Thummel KE, Isoherranen N. Stereochemical aspects of itraconazole metabolism in vitro and in vivo. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 583-90. PMID 16415110 DOI: 10.1124/Dmd.105.008508 |
0.308 |
|
| 2001 |
Upthagrove AL, Nelson WL. Importance of amine pKa and distribution coefficient in the metabolism of fluorinated propranolol analogs: metabolism by CYP1A2. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 1389-95. PMID 11602513 |
0.735 |
|
| 2001 |
Upthagrove AL, Nelson WL. Importance of amine pKa and distribution coefficient in the metabolism of fluorinated propranolol derivatives. Preparation, identification of metabolite regioisomers, and metabolism by CYP2D6. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 1377-88. PMID 11602512 |
0.753 |
|
| 2001 |
Upthagrove AL, Nelson WL. Carbinolamines, imines, and oxazolidines from fluorinated propranolol analogs. (19)F NMR and mass spectral characterization and evidence for formation as intermediates in cytochrome P450-catalyzed N-dealkylation. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 29: 1114-22. PMID 11454730 |
0.742 |
|
| 1999 |
Upthagrove AL, Hackett M, Nelson WL. Mass spectral fragmentation pathways of propranolol related beta-fluorinated amines studied by electrospray and electron impact ionization. Rapid Communications in Mass Spectrometry : Rcm. 13: 1671-9. PMID 10440986 DOI: 10.1002/(Sici)1097-0231(19990830)13:16<1671::Aid-Rcm696>3.0.Co;2-V |
0.74 |
|
| 1999 |
Upthagrove AL, Hackett M, Nelson WL. Fragmentation pathways of selectively labeled uropranolol using electrospray ionization on an ion trap mass spectrometer and comparison with ions formed by electron impact. Rapid Communications in Mass Spectrometry : Rcm. 13: 534-41. PMID 10204247 DOI: 10.1002/(Sici)1097-0231(19990330)13:6<534::Aid-Rcm520>3.0.Co;2-F |
0.731 |
|
| 1997 |
Palmer RB, Upthagrove AL, Nelson WL. (E)- and (Z)-7-arylidenenaltrexones: synthesis and opioid receptor radioligand displacement assays. Journal of Medicinal Chemistry. 40: 749-53. PMID 9057861 DOI: 10.1021/Jm960573F |
0.74 |
|
| 1995 |
Davis RD, Nelson WL. Isothiocyanate-substituted benzyl ether opioid receptor ligands derived from 6β-naltrexol Journal of Medicinal Chemistry. 38: 570-579. PMID 7853350 DOI: 10.1021/Jm00003A020 |
0.348 |
|
| 1994 |
Weerawarna SA, Davis RD, Nelson WL. Isothiocyanate-substituted κ-selective opioid receptor ligands derived from N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]phenylacetamide Journal of Medicinal Chemistry. 37: 2856-2864. PMID 8071934 DOI: 10.1021/Jm00044A006 |
0.378 |
|
| 1994 |
Nelson TD, Davis RD, Nelson WL. Synthesis and opioid receptor affinity of a series of aralkyl ethers of 6α- and 6β-naltrexol Journal of Medicinal Chemistry. 37: 4270-4277. PMID 7996538 DOI: 10.1021/Jm00051A003 |
0.307 |
|
| 1992 |
Klein P, Nelson WL. O3-(2-carbomethoxyallyl) ethers of opioid ligands derived from oxymorphone, naltrexone, etorphine, diprenorphine, norbinaltorphimine, and naltrindole. Unexpected O3-dealkylation in the opioid radioligand displacement assay Journal of Medicinal Chemistry. 35: 4589-4594. PMID 1335078 DOI: 10.1021/Jm00102A012 |
0.306 |
|
| 1992 |
Portoghese PS, Sultana M, Nelson WL, Klein P, Takemori AE. Delta opioid antagonist activity and binding studies of regioisomeric isothiocyanate derivatives of naltrindole: evidence for delta receptor subtypes. Journal of Medicinal Chemistry. 35: 4086-91. PMID 1331455 DOI: 10.1021/Jm00100A014 |
0.506 |
|
| 1992 |
Dasher WE, Klein P, Nelson WL. Electrophilic opioid ligands. Oxygen tethered α-methylene-γ-lactone, acrylate, isothiocyanate, and epoxide derivatives of 6β-naltrexol Journal of Medicinal Chemistry. 35: 2374-2384. PMID 1320121 DOI: 10.1021/Jm00091A005 |
0.353 |
|
| 1991 |
Weerawarna SA, Geisshüsler SM, Murthy SS, Nelson WL. Enantioselective and diastereoselective hydroxylation of bufuralol. Absolut configuration of the 7-(1-hydroxyethyl)-2-[1-hydroxy-2-(tert-butylamino)ethyl]benzofurans, the benzylic hydroxylation metabolites Journal of Medicinal Chemistry. 34: 3091-3097. PMID 1681107 DOI: 10.1021/Jm00114A019 |
0.355 |
|
| 1991 |
Klein P, Nelson WL. Electrophilic γ-lactone κ-opioid receptor probes. Analogues of 2'-hydroxy-2-tetrahydrofurfuryl-5,9-dimethyl-6,7-benzomorphan diastereomers Journal of Medicinal Chemistry. 34: 2438-2444. PMID 1652019 DOI: 10.1021/Jm00112A019 |
0.362 |
|
| 1991 |
Weerawarna SA, Guha‐Biswas M, Nelson WL. Benzofurans. Improved syntheses of bufuralol, 7‐ethyl‐2‐(2‐tert‐butylamino‐1‐hydroxyethyl)benzofuran, and 1″‐oxobufuralol, 7‐acetyl‐2‐(2‐tert‐butylamino‐1‐hydroxyethyl)benzofuran Journal of Heterocyclic Chemistry. 28: 1395-1403. DOI: 10.1002/Jhet.5570280535 |
0.308 |
|
| 1990 |
Murthy SS, Shetty HU, Nelson WL, Jackson pR, Lennard MS. Enantioselective and diastereoselective aspects of the oxidative metabolism of metoprolol Biochemical Pharmacology. 40: 1637-1644. PMID 2222517 DOI: 10.1016/0006-2952(90)90466-X |
0.303 |
|
| 1990 |
Klein P, Nelson WL, Yao YH, Simon EJ. Electrophilic α-methylene-γ-lactone and isothiocyanate opioid ligands related to etorphine Journal of Medicinal Chemistry. 33: 2286-2296. PMID 2165166 DOI: 10.1021/Jm00170A038 |
0.358 |
|
| 1990 |
Olsen LD, Klein P, Nelson WL, Yao YH, Simon EJ. Conjugate addition ligands of opioid antagonists. Methacrylate esters and ethers of 6α- and 6β-naltrexol Journal of Medicinal Chemistry. 33: 737-741. PMID 2153826 DOI: 10.1021/Jm00164A043 |
0.325 |
|
| 1988 |
Shetty HU, Nelson WL. Chemical aspects of metoprolol metabolism. Asymmetric synthesis and absolute configuration of the 3-[4-(1-hydroxy-2-methoxyethyl)phenoxy]-1-(isopropylamino)-2-propanols, the diastereomeric benzylic hydroxylation metabolites Journal of Medicinal Chemistry. 31: 55-59. PMID 3336032 DOI: 10.1021/Jm00396A009 |
0.374 |
|
| 1987 |
Theodore LJ, Nelson WL. Stereospecific synthesis of the enantiomers of verapamil and gallopamil Journal of Organic Chemistry. 52: 1309-1315. DOI: 10.1021/Jo00383A026 |
0.329 |
|
| 1986 |
Umesha Shetty H, Nelson WL. Chemical and stereochemical aspects of propranolol metabolism. Diastereomeric 1-(1-hydroxy-2-propylamino)-3-(1-naphthoxy)-2-propanols produced by rat liver microsomal ω-hydroxylation Journal of Medicinal Chemistry. 29: 2004-2008. PMID 3761318 DOI: 10.1021/Jm00160A034 |
0.332 |
|
| 1985 |
Umesha Shetty H, Nelson WL. Attempts to use cyanide ion to trap imine intermediates in the microsomal N‐dealkylation of propranolol: Formation of α‐aminonitriles as artifacts when using ether for extraction Journal of Pharmaceutical Sciences. 74: 968-971. PMID 4067851 DOI: 10.1002/Jps.2600740912 |
0.369 |
|
| 1985 |
Koolpe GA, Nelson WL, Gioannini TL, Angel L, Appelmans N, Simon EJ. Opioid agonists and antagonists. 6-Desoxy-6-substituted lactone, epoxide, and glycidate ester derivatives of naltrexone and oxymorphone. Journal of Medicinal Chemistry. 28: 949-57. PMID 2409280 DOI: 10.1021/Jm00145A018 |
0.367 |
|
| 1985 |
KOOLPE GA, NELSON WL, GIOANNINI TL, ANGEL L, APPELMANS N, SIMON EJ. ChemInform Abstract: OPIOID AGONISTS AND ANTAGONISTS. 6-DESOXY-6-SUBSTITUTED LACTONE, EPOXIDE, AND GLYCIDATE ESTER DERIVATIVES OF NALTREXONE AND OXYMORPHONE Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198544212 |
0.322 |
|
| 1985 |
KOOLPE GA, NELSON WL, GIOANNINI TL, ANGEL L, SIMON EJ. ChemInform Abstract: DIASTEREOMERIC 6-DESOXY-6-SPIRO-α-METHYLENE-Γ-BUTYROLACTONE DERIVATIVES OF NALTREXONE AND OXYMORPHONE. SELECTIVE IRREVERSIBLE INHIBITION OF NALTREXONE BINDING IN AN OPIOID RECEPTOR PREPARATION BY A CONFORMATIONALLY RESTRICTED MICHAEL Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198523209 |
0.32 |
|
| 1984 |
Ko RP, Gupte SM, Nelson WL. Opioid agonists and antagonists. 6,6-Hydrazi and 6-oximino derivatives of 14-hydroxydihydromorphinones. Journal of Medicinal Chemistry. 27: 1727-9. PMID 6389867 DOI: 10.1021/Jm00378A034 |
0.331 |
|
| 1984 |
Nelson WL, Bartels MJ, Bednarski PJ, Zhang S, Messick K, Horng JS, Ruffolo RR. The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite. Journal of Medicinal Chemistry. 27: 857-61. PMID 6330358 DOI: 10.1021/Jm00373A008 |
0.377 |
|
| 1984 |
Koolpe GA, Nelson WL, Gioannini TL, Angel L, Simon EJ. Diastereomeric 6-desoxy-6-spiro-α-methylene-γ-butyrolactone derivatives of naltrexone and oxymorphone. Selective irreversible inhibition of naltrexone binding in an opioid receptor preparation by a conformationally restricted Michael acceptor ligand Journal of Medicinal Chemistry. 27: 1718-1723. PMID 6209395 DOI: 10.1021/Jm00378A032 |
0.355 |
|
| 1984 |
NELSON WL, BARTELS MJ, BEDNARSKI PJ, ZHANG S, MESSICK K, HORNG JS, RUFFOLO RRJ. ChemInform Abstract: 3,4-CATECHOL DERIVATIVE OF PROPRANOLOL, A MINOR DIHYDROXYLATED METABOLITE Chemischer Informationsdienst. 15. DOI: 10.1002/Chin.198448166 |
0.329 |
|
| 1983 |
Chen C‐, Nelson WL. Chemical aspects of propranolol metabolism: 1,1‐diethoxy‐3‐(1‐naphthoxy)‐2‐propanol and related ring‐closure products cis‐ and trans‐4‐ethoxy‐3‐hydroxy‐3,4‐dihydro‐2H‐naphtho[1,2‐b]pyran Journal of Pharmaceutical Sciences. 72: 863-865. PMID 6620138 DOI: 10.1002/Jps.2600720807 |
0.354 |
|
| 1983 |
Zhang S, Powell ML, Nelson WL, Wirth PJ. Derivatives of β-adrenergie antagonists. N-nitrosopropranolol and N-hydroxypropranolol and its aldonitrone Journal of Medicinal Chemistry. 26: 455-458. PMID 6131136 DOI: 10.1002/Chin.198334171 |
0.327 |
|
| 1981 |
Fuder H, Nelson WL, Miller DD, Patil PN. Alpha adrenoreceptors of rabbit aorta and stomach fundus Journal of Pharmacology and Experimental Therapeutics. 217: 1-9. PMID 6110772 |
0.42 |
|
| 1980 |
NELSON WL, POWELL ML, DYER DC. ChemInform Abstract: ABSOLUTE CONFIGURATION OF GLYCEROL DERIVATIVES. 7. ENANTIOMERS OF 2-(((2-(2,6-DIMETHOXYPHENOXY)ETHYL)AMINO)ETHYL)-1,4-BENZODIOXANE (WB-4101), A POTENT COMPETITIVE α-ADRENERGIC ANTAGONIST Chemischer Informationsdienst. 11. DOI: 10.1002/Chin.198005274 |
0.331 |
|
| 1979 |
Burke TR, Nelson WL, Buckner CK. Synthesis of 4′- and 5′-hydroxyoxprenolol: Pharmacologically active ring-hydroxylated metabolites of oxprenolol Journal of Medicinal Chemistry. 22: 1535-1537. PMID 536997 DOI: 10.1002/Chin.198016147 |
0.351 |
|
| 1979 |
Nelson WL, Burke TR. Metabolism of β-adrenergic antagonists. Evidence for an arene oxide-NIH shift pathway in the aromatic hydroxylation of oxprenolol Journal of Medicinal Chemistry. 22: 1088-1092. PMID 490554 DOI: 10.1002/Chin.198005193 |
0.332 |
|
| 1979 |
Nelson WL, Burke TR. Aromatic hydroxylation of β-adrenergic antagonists. Formation of 4′- and 5′-hydroxy-1-(isopropylamino)-3-[2′-(allyloxy)phenoxy]-2-propanol from oxprenolol Journal of Medicinal Chemistry. 22: 1082-1088. PMID 490553 DOI: 10.1002/Chin.198005192 |
0.363 |
|
| 1979 |
Nelson WL, Powell ML, Dyer DC. Absolute configuration of glycerol derivatives. 7. Enantiomers of 2-[[[2-(2,6-dimethoxyphenoxy)ethyl]amino]methyl]-1,4-benzodioxane (WB-4101), a potent competitive α-adrenergic antagonist Journal of Medicinal Chemistry. 22: 1125-1127. PMID 40029 DOI: 10.1021/Jm00195A024 |
0.319 |
|
| 1978 |
Nelson SD, Nelson WL, Trager WF. N-hydroxyamide metabolites of lidocaine. Synthesis, characterization, quantitation, and mutagenic potential Journal of Medicinal Chemistry. 21: 721-725. PMID 690997 DOI: 10.1002/Chin.197851153 |
0.301 |
|
| 1978 |
Nelson WL, Burke TR. Absolute configuration of glycerol derivatives. 5. Oxprenolol enantiomers Journal of Organic Chemistry. 43: 3641-3645. DOI: 10.1021/Jo00413A002 |
0.311 |
|
| 1978 |
Nelson WL, Powell ML, Wennerstrom JE. Absolute configuration of glycerol derivatives. 6. Cupra A circular dichroism spectra of 3-(aryloxy)-1-(alkylamino)-2-propanol β-adrenergic blocking agents Journal of Organic Chemistry. 43: 4907-4910. DOI: 10.1002/Chin.197918056 |
0.306 |
|
| 1976 |
Nelson WL, Freeman DS, Vincenzi FF. Stereochemical analogs of a muscarinic, ganglionic stimulant. 3. 2,3-Substituted bicyclo[2.2.1]hept-5-enes and -heptanes related to 4-[N-(3-Chlorophenyl)carbamoyloxy]-2-butynyltrimethylammonium chloride (McN-A-343) Journal of Medicinal Chemistry. 19: 159-160. PMID 54427 DOI: 10.1021/Jm00223A027 |
0.326 |
|
| 1976 |
Nelson WL, Freeman DS, Vincenzi FF. Stereochemical analogs of a muscarinic, ganglionic stimulant. 2. Cis and trans olefinic, epoxide, and cyclopropane analogs related to 4-[N-(3-Chlorophenyl)carbamoyloxy]-2-butynyltrimethylammonium chloride (McN-A-343) Journal of Medicinal Chemistry. 19: 153-158. PMID 54426 DOI: 10.1021/Jm00223A026 |
0.35 |
|
| 1976 |
NELSON WL, FREEMAN DS, VINCENZI FF. ChemInform Abstract: STEREOCHEMICAL ANALOGS OF A MUSCARINIC, GANGLIONIC STIMULANT. 3. 2,3-SUBSTITUTED BICYCLO(2.2.1)HEPT-5-ENES AND -HEPTANES RELATED TO 4-(N-(3-CHLOROPHENYL)CARBAMOYLOXY)-2-BUTYNYLTRIMETHYLAMMONIUM CHLORIDE Chemischer Informationsdienst. 7: no-no. DOI: 10.1002/Chin.197617189 |
0.304 |
|
| 1974 |
Nelson WL, Sherwood BE. Octahydrophenanthreneaziridines. syn- and anti-9,10-imino-1,2,3,4,4a,9,10,10a-(trans-4a,10a)-octahydrophenanthrene Journal of Organic Chemistry. 39: 66-69. DOI: 10.1021/Jo00915A013 |
0.305 |
|
| 1972 |
Nelson WL, Allen DR, Vincenzi FF. Muscarinic receptorss: 2-trimethylammonium-7-oxabicyclo[2.2.1]heptane iodide epoxides and 2-trimethylammoniumbicyclo[2.2.1]heptane iodides Journal of Pharmaceutical Sciences. 61: 1640-1642. PMID 5072417 DOI: 10.1002/Jps.2600611023 |
0.311 |
|
| 1972 |
Nelson WL, Allen DR. Derivatives of 7-Oxabicyclo[2.2.1 ]hept-5-ene and 7-Oxabicyclo[2.2.1 ] heptane. Synthesis, transformations, and stereochemistry using nmr methods Journal of Heterocyclic Chemistry. 9: 561-568. DOI: 10.1002/Jhet.5570090317 |
0.31 |
|
| 1971 |
Nelson WL, Wong JK, Vincenzi FF, Blake PH, Smith DL. Muscarinic receptors: 4-substituted-3-trimethyl-ammoniumtetrahydrofuran halides. Journal of Pharmaceutical Sciences. 59: 1676-9. PMID 5500450 DOI: 10.1002/Jps.2600591134 |
0.337 |
|
| 1971 |
Nelson WL, Allen DR, Vincenzi FF. Muscarinic receptors. Derivatives of 7-oxabicyclo[2.2.1]heptane Journal of Medicinal Chemistry. 14: 698-702. PMID 5114065 DOI: 10.1021/Jm00290A007 |
0.319 |
|
| 1970 |
Nelson WL, Miller DD. Tricyclic norephedrine analogs. The isomeric 9-hydroxy-10-amino-1,2,3,4,4a,9,10,10a-(trans-4a,10a)-octahydrophenanthrenes Journal of Medicinal Chemistry. 13: 807-814. PMID 4394055 DOI: 10.1021/Jm00299A005 |
0.483 |
|
| 1970 |
Nelson WL, Miller DD, Shefter E. Acetyl nitrate addition to cyclic olefins. The isomeric 9-acetoxy-10-nitro-1,2,3,4,4a,9,10,10a-(trans-4a,10a)-octahydrophenanthrenes Journal of Organic Chemistry. 35: 3433-3436. DOI: 10.1021/Jo00835A054 |
0.472 |
|
| 1970 |
Nelson WL, Miller DD. Oxazoline formation from N-acylaziridines. Isolation of an intermediate in an octahydrophenanthrene system Journal of Organic Chemistry. 35: 1185-1187. DOI: 10.1021/Jo00829A076 |
0.454 |
|
| 1969 |
Nelson WL, Miller DD, Wilson RS. Cyclic lactams. The hexahydrodibenzazepinones from l,2,3,4,4a,9,10,10a-(trans-4a,10a)-octahydro-9-oxophenanthrene Journal of Heterocyclic Chemistry. 6: 131-133. DOI: 10.1002/Jhet.5570060127 |
0.45 |
|
| 1968 |
Nelson WL. Oxazolidine formation in the attempted eschweiler-clarke reductive methylation ofcis-3-aminobicyclo[2.2.2] octan-2-ol Journal of Heterocyclic Chemistry. 5: 231-233. DOI: 10.1002/Jhet.5570050214 |
0.317 |
|
| 1966 |
Smissman EE, Nelson WL, LaPidus JB, Day JL. Conformational aspects of acetylcholine receptor sites. The isomeric 3-trimethylammonium-2-acetoxy-trans-decalin halides and the isomeric alpha,beta-dimethylacetylcholine halides. Journal of Medicinal Chemistry. 9: 458-65. PMID 5968006 DOI: 10.1021/Jm00322A002 |
0.694 |
|
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