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Aaron M. Ring, M.D./Ph.D. - Publications

Affiliations: 
2016- Yale University School of Medicine, New Haven, CT 
Area:
Immunology, protein engineering, pharmacology, cancer immunotherapy
Website:
https://medicine.yale.edu/immuno/programs/aaron_ring-2.profile
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37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Song E, Zhang C, Israelow B, Lu-Culligan A, Prado AV, Skriabine S, Lu P, Weizman OE, Liu F, Dai Y, Szigeti-Buck K, Yasumoto Y, Wang G, Castaldi C, Heltke J, ... ... Ring A, et al. Neuroinvasion of SARS-CoV-2 in human and mouse brain. Biorxiv : the Preprint Server For Biology. PMID 32935108 DOI: 10.1101/2020.06.25.169946  0.4
2020 Song E, Chow RD, Jiang R, Zamecnik CR, Loudermilk RP, Dai Y, Liu F, Geng B, Chiarella J, Israelow B, Casanovas-Massana A, Ko AI, Ring A, Kleinstein SH, Spudich S, et al. Immunologically distinct responses occur in the CNS of COVID-19 patients. Biorxiv : the Preprint Server For Biology. PMID 32935102 DOI: 10.1101/2020.09.11.293464  0.4
2020 Cao Y, Rosen C, Arora G, Gupta A, Booth CJ, Murfin KE, Cerny J, Marin Lopez A, Chuang YM, Tang X, Pal U, Ring A, Narasimhan S, Fikrig E. An protein disulfide isomerase contributes to colonization of the vector. Infection and Immunity. PMID 32928964 DOI: 10.1128/IAI.00426-20  0.44
2020 Takahashi T, Ellingson MK, Wong P, Israelow B, Lucas C, Klein J, Silva J, Mao T, Oh JE, Tokuyama M, Lu P, Venkataraman A, Park A, Liu F, Meir A, ... ... Ring AM, et al. Sex differences in immune responses that underlie COVID-19 disease outcomes. Nature. PMID 32846427 DOI: 10.1038/s41586-020-2700-3  0.4
2020 Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. The Journal of Experimental Medicine. 217. PMID 32750141 DOI: 10.1084/jem.20201241  0.4
2020 Goldman-Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer R, Ring A, Wilen C, Iwasaki A. Mouse Model of SARS-CoV-2 Reveals Inflammatory Role of Type I Interferon Signaling. Ssrn. 3628297. PMID 32714125 DOI: 10.2139/ssrn.3628297  0.4
2020 Takahashi T, Wong P, Ellingson M, Lucas C, Klein J, Israelow B, Silva J, Oh J, Mao T, Tokuyama M, Lu P, Venkataraman A, Park A, Liu F, Meir A, ... ... Ring A, et al. Sex differences in immune responses to SARS-CoV-2 that underlie disease outcomes. Medrxiv : the Preprint Server For Health Sciences. PMID 32577695 DOI: 10.1101/2020.06.06.20123414  0.4
2020 Israelow B, Song E, Mao T, Lu P, Meir A, Liu F, Alfajaro MM, Wei J, Dong H, Homer RJ, Ring A, Wilen CB, Iwasaki A. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. Biorxiv : the Preprint Server For Biology. PMID 32577647 DOI: 10.1101/2020.05.27.118893  0.4
2020 Hosier H, Farhadian SF, Morotti RA, Deshmukh U, Lu-Culligan A, Campbell KH, Yasumoto Y, Vogels CB, Casanovas-Massana A, Vijayakumar P, Geng B, Odio CD, Fournier J, Brito AF, Fauver JR, ... ... Ring AM, et al. SARS-CoV-2 infection of the placenta. The Journal of Clinical Investigation. PMID 32573498 DOI: 10.1172/JCI139569  0.4
2019 Anderson KL, Snyder KM, Ito D, Lins DC, Mills LJ, Weiskopf K, Ring NG, Ring AM, Shimizu Y, Mescher MF, Weissman IL, Modiano JF. Evolutionarily conserved resistance to phagocytosis observed in melanoma cells is insensitive to upregulation of pro-phagocytic signals and to CD47 blockade. Melanoma Research. PMID 31205227 DOI: 10.1097/CMR.0000000000000629  0.84
2018 McMahon C, Baier AS, Pascolutti R, Wegrecki M, Zheng S, Ong JX, Erlandson SC, Hilger D, Rasmussen SGF, Ring AM, Manglik A, Kruse AC. Yeast surface display platform for rapid discovery of conformationally selective nanobodies. Nature Structural & Molecular Biology. PMID 29434346 DOI: 10.1038/s41594-018-0028-6  0.32
2018 Barkal AA, Weiskopf K, Kao KS, Gordon SR, Rosental B, Yiu YY, George BM, Markovic M, Ring NG, Tsai JM, McKenna KM, Ho PY, Cheng RZ, Chen JY, Barkal LJ, ... Ring AM, et al. Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy. Nature Immunology. 19: 76-84. PMID 29180808 DOI: 10.1038/s41590-017-0004-z  0.84
2017 Ring NG, Herndler-Brandstetter D, Weiskopf K, Shan L, Volkmer JP, George BM, Lietzenmayer M, McKenna KM, Naik TJ, McCarty A, Zheng Y, Ring AM, Flavell RA, Weissman IL. Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 29158380 DOI: 10.1073/pnas.1710877114  0.84
2017 Gordon SR, Maute RL, Dulken BW, Hutter G, George BM, McCracken MN, Gupta R, Tsai JM, Sinha R, Corey D, Ring AM, Connolly AJ, Weissman IL. PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity. Nature. PMID 28514441 DOI: 10.1038/nature22396  0.84
2017 Ho CC, Chhabra A, Starkl P, Schnorr PJ, Wilmes S, Moraga I, Kwon HS, Gaudenzio N, Sibilano R, Wehrman TS, Gakovic M, Sockolosky JT, Tiffany MR, Ring AM, Piehler J, et al. Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling. Cell. 168: 1041-1052.e18. PMID 28283060 DOI: 10.1016/j.cell.2017.02.011  0.84
2016 Weiskopf K, Anderson KL, Ito D, Schnorr PJ, Tomiyasu H, Ring AM, Bloink K, Efe J, Rue S, Lowery D, Barkal A, Prohaska S, McKenna KM, Cornax I, O'Brien TD, et al. Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20. Cancer Immunology Research. PMID 27856424 DOI: 10.1158/2326-6066.CIR-16-0105  0.84
2016 Pascolutti R, Sun X, Kao J, Maute RL, Ring AM, Bowman GR, Kruse AC. Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant. Structure (London, England : 1993). PMID 27618663 DOI: 10.1016/j.str.2016.06.026  0.84
2016 Chhabra A, Ring AM, Weiskopf K, Schnorr PJ, Gordon S, Le AC, Kwon HS, Ring NG, Volkmer J, Ho PY, Tseng S, Weissman IL, Shizuru JA. Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy. Science Translational Medicine. 8: 351ra105. PMID 27510901 DOI: 10.1126/scitranslmed.aae0501  0.84
2016 Weiskopf K, Jahchan NS, Schnorr PJ, Cristea S, Ring AM, Maute RL, Volkmer AK, Volkmer JP, Liu J, Lim JS, Yang D, Seitz G, Nguyen T, Wu D, Jude K, et al. CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. The Journal of Clinical Investigation. PMID 27294525 DOI: 10.1172/JCI81603  0.84
2015 Mitra S, Ring AM, Amarnath S, Spangler JB, Li P, Ju W, Fischer S, Oh J, Spolski R, Weiskopf K, Kohrt H, Foley JE, Rajagopalan S, Long EO, Fowler DH, et al. Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps. Immunity. 42: 826-38. PMID 25992859 DOI: 10.1016/j.immuni.2015.04.018  0.84
2015 Spangler JB, Tomala J, Luca VC, Jude KM, Dong S, Ring AM, Votavova P, Pepper M, Kovar M, Garcia KC. Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Immunity. 42: 815-25. PMID 25992858 DOI: 10.1016/j.immuni.2015.04.015  0.84
2015 Ho CC, Guo N, Sockolosky JT, Ring AM, Weiskopf K, Özkan E, Mori Y, Weissman IL, Garcia KC. "Velcro" engineering of high affinity CD47 ectodomain as signal regulatory protein α (SIRPα) antagonists that enhance antibody-dependent cellular phagocytosis. The Journal of Biological Chemistry. 290: 12650-63. PMID 25837251 DOI: 10.1074/jbc.M115.648220  0.84
2014 Ardolino M, Azimi CS, Iannello A, Trevino TN, Horan L, Zhang L, Deng W, Ring AM, Fischer S, Garcia KC, Raulet DH. Cytokine therapy reverses NK cell anergy in MHC-deficient tumors. The Journal of Clinical Investigation. 124: 4781-94. PMID 25329698 DOI: 10.1172/JCI74337  0.84
2013 Weiskopf K, Ring AM, Schnorr PJ, Volkmer JP, Volkmer AK, Weissman IL, Garcia KC. Improving macrophage responses to therapeutic antibodies by molecular engineering of SIRPα variants. Oncoimmunology. 2: e25773. PMID 24319639 DOI: 10.4161/onci.25773  0.84
2013 Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, et al. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature. 504: 101-6. PMID 24256733 DOI: 10.1038/nature12735  0.84
2013 Ring AM, Manglik A, Kruse AC, Enos MD, Weis WI, Garcia KC, Kobilka BK. Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody. Nature. 502: 575-9. PMID 24056936 DOI: 10.1038/nature12572  0.84
2013 Weiskopf K, Ring AM, Ho CC, Volkmer JP, Levin AM, Volkmer AK, Ozkan E, Fernhoff NB, van de Rijn M, Weissman IL, Garcia KC. Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies. Science (New York, N.Y.). 341: 88-91. PMID 23722425 DOI: 10.1126/science.1238856  0.84
2013 Sitrin J, Ring A, Garcia KC, Benoist C, Mathis D. Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2. The Journal of Experimental Medicine. 210: 1153-65. PMID 23650440 DOI: 10.1084/jem.20122248  0.84
2012 Ring AM, Lin JX, Feng D, Mitra S, Rickert M, Bowman GR, Pande VS, Li P, Moraga I, Spolski R, Ozkan E, Leonard WJ, Garcia KC. Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nature Immunology. 13: 1187-95. PMID 23104097 DOI: 10.1038/ni.2449  0.84
2012 Levin AM, Bates DL, Ring AM, Krieg C, Lin JT, Su L, Moraga I, Raeber ME, Bowman GR, Novick P, Pande VS, Fathman CG, Boyman O, Garcia KC. Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Nature. 484: 529-33. PMID 22446627 DOI: 10.1038/nature10975  0.84
2012 Willingham SB, Volkmer JP, Weiskopf K, Ring AM, Weissman IL. Reply to Soto-Pantoja et al. and Zhao et al.: Targeting CD47 on human solid tumors Proceedings of the National Academy of Sciences of the United States of America. 109: E2844-E2845. DOI: 10.1073/pnas.1209743109  0.84
2011 Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP. WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. The Journal of Biological Chemistry. 286: 30171-80. PMID 21733846 DOI: 10.1074/jbc.M111.222893  0.84
2009 San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G. Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 106: 4384-9. PMID 19240212 DOI: 10.1073/pnas.0813238106  0.84
2008 Kahle KT, Ring AM, Lifton RP. Molecular physiology of the WNK kinases Annual Review of Physiology. 70: 329-355. DOI: 10.1146/annurev.physiol.70.113006.100651  0.84
2007 Ring AM, Leng Q, Rinehart J, Wilson FH, Kahle KT, Hebert SC, Lifton RP. An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 104: 4025-9. PMID 17360471 DOI: 10.1073/pnas.0611728104  0.84
2007 Ring AM, Cheng SX, Leng Q, Kahle KT, Rinehart J, Lalioti MD, Volkman HM, Wilson FH, Hebert SC, Lifton RP. WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 104: 4020-4. PMID 17360470 DOI: 10.1073/pnas.0611727104  0.84
2006 Kahle KT, Rinehart J, Ring A, Gimenez I, Gamba G, Hebert SC, Lifton RP. WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters. Physiology (Bethesda, Md.). 21: 326-35. PMID 16990453 DOI: 10.1152/physiol.00015.2006  0.84
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