Year |
Citation |
Score |
2024 |
Ingram Z, Kline C, Hughson AK, Singh PK, Fischer HL, Sowd GA, Watkins SC, Kane M, Engelman AN, Ambrose Z. Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration. Biorxiv : the Preprint Server For Biology. PMID 38645162 DOI: 10.1101/2024.04.08.588584 |
0.535 |
|
2024 |
Jing T, Shan Z, Dinh T, Biswas A, Jang S, Greenwood J, Li M, Zhang Z, Gray G, Shin HJ, Zhou B, Passos D, Aiyer S, Li Z, Craigie R, ... Engelman AN, et al. Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding. Biorxiv : the Preprint Server For Biology. PMID 38328132 DOI: 10.1101/2024.01.26.577436 |
0.52 |
|
2023 |
Mohammadi A, Etemad B, Zhang X, Li Y, Bedwell GJ, Sharaf R, Kittilson A, Melberg M, Crain CR, Traunbauer AK, Wong C, Fajnzylber J, Worrall DP, Rosenthal A, Jordan H, ... ... Engelman AN, et al. Viral and host mediators of non-suppressible HIV-1 viremia. Nature Medicine. PMID 37957382 DOI: 10.1038/s41591-023-02611-1 |
0.509 |
|
2023 |
Jang S, Engelman AN. Capsid-host interactions for HIV-1 ingress. Microbiology and Molecular Biology Reviews : Mmbr. e0004822. PMID 37750702 DOI: 10.1128/mmbr.00048-22 |
0.54 |
|
2023 |
Irie WC, Chitneni P, Glynn TR, Allen W, Chai PR, Engelman AN, Hurtado R, Li JZ, Li P, Lockman S, Marcus JL, Ogunshola FJ, Rönn MM, Haberer J, Ghebremichael M, et al. Pathways and Intersections: Multifaceted Approaches to Engage Individuals From Underrepresented and Marginalized Communities in HIV Research and Career Development. Journal of Acquired Immune Deficiency Syndromes (1999). 94: S116-S121. PMID 37707858 DOI: 10.1097/QAI.0000000000003265 |
0.385 |
|
2023 |
Mohammadi A, Etemad B, Zhang X, Li Y, Bedwell GJ, Sharaf R, Kittilson A, Melberg M, Wong C, Fajnzylber J, Worrall DP, Rosenthal A, Jordan H, Jilg N, Kaseke C, ... ... Engelman AN, et al. Viral and Host Mediators of Non-Suppressible HIV-1 Viremia. Medrxiv : the Preprint Server For Health Sciences. PMID 37034605 DOI: 10.1101/2023.03.30.23287124 |
0.5 |
|
2023 |
Shen Q, Kumari S, Xu C, Jang S, Shi J, Burdick RC, Levintov L, Xiong Q, Wu C, Devarkar SC, Tian T, Tripler TN, Hu Y, Yuan S, Temple J, ... ... Engelman AN, et al. The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores. Proceedings of the National Academy of Sciences of the United States of America. 120: e2202815120. PMID 36943880 DOI: 10.1073/pnas.2202815120 |
0.502 |
|
2023 |
Shen Q, Feng Q, Wu C, Xiong Q, Tian T, Yuan S, Shi J, Bedwell GJ, Yang R, Aiken C, Engelman AN, Lusk CP, Lin C, Xiong Y. Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels. Nature Structural & Molecular Biology. PMID 36807645 DOI: 10.1038/s41594-023-00925-9 |
0.522 |
|
2023 |
Singer MR, Dinh T, Levintov L, Annamalai AS, Rey JS, Briganti L, Cook NJ, Pye VE, Taylor IA, Kim K, Engelman AN, Kim B, Perilla JR, Kvaratskhelia M, Cherepanov P. The Drug-Induced Interface That Drives HIV-1 Integrase Hypermultimerization and Loss of Function. Mbio. e0356022. PMID 36744954 DOI: 10.1128/mbio.03560-22 |
0.491 |
|
2022 |
Wei G, Iqbal N, Courouble VV, Francis AC, Singh PK, Hudait A, Annamalai AS, Bester S, Huang SW, Shkriabai N, Briganti L, Haney R, KewalRamani VN, Voth GA, Engelman AN, et al. Prion-like low complexity regions enable avid virus-host interactions during HIV-1 infection. Nature Communications. 13: 5879. PMID 36202818 DOI: 10.1038/s41467-022-33662-6 |
0.539 |
|
2022 |
Singh PK, Li W, Bedwell GJ, Fadel HJ, Poeschla EM, Engelman AN. Allosteric Integrase Inhibitor Influences on HIV-1 Integration and Roles of LEDGF/p75 and HDGFL2 Host Factors. Viruses. 14. PMID 36146690 DOI: 10.3390/v14091883 |
0.524 |
|
2022 |
Francis AC, Cereseto A, Singh PK, Shi J, Poeschla E, Engelman AN, Aiken C, Melikyan GB. Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles. Plos Pathogens. 18: e1010754. PMID 35951676 DOI: 10.1371/journal.ppat.1010754 |
0.432 |
|
2022 |
Zhang Q, Wang S, Li W, Yau E, Hui H, Singh PK, Achuthan V, Young Karris MA, Engelman AN, Rana TM. Genome-wide CRISPR/Cas9 transcriptional activation screen identifies a histone acetyltransferase inhibitor complex as a regulator of HIV-1 integration. Nucleic Acids Research. PMID 35713529 DOI: 10.1093/nar/gkac464 |
0.554 |
|
2022 |
Engelman AN, Kvaratskhelia M. Multimodal Functionalities of HIV-1 Integrase. Viruses. 14. PMID 35632668 DOI: 10.3390/v14050926 |
0.43 |
|
2022 |
Ballandras-Colas A, Chivukula V, Gruszka DT, Shan Z, Singh PK, Pye VE, McLean RK, Bedwell GJ, Li W, Nans A, Cook NJ, Fadel HJ, Poeschla EM, Griffiths DJ, Vargas J, ... ... Engelman AN, et al. Multivalent interactions essential for lentiviral integrase function. Nature Communications. 13: 2416. PMID 35504909 DOI: 10.1038/s41467-022-29928-8 |
0.377 |
|
2022 |
Singh PK, Bedwell GJ, Engelman AN. Spatial and Genomic Correlates of HIV-1 Integration Site Targeting. Cells. 11. PMID 35203306 DOI: 10.3390/cells11040655 |
0.482 |
|
2021 |
Liu S, Koneru PC, Li W, Pathirage C, Engelman AN, Kvaratskhelia M, Musier-Forsyth K. HIV-1 integrase binding to genomic RNA 5'-UTR induces local structural changes in vitro and in virio. Retrovirology. 18: 37. PMID 34809662 DOI: 10.1186/s12977-021-00582-0 |
0.444 |
|
2021 |
Rey JS, Li W, Bryer AJ, Beatson H, Lantz C, Engelman AN, Perilla JR. Deep-learning in situ classification of HIV-1 virion morphology. Computational and Structural Biotechnology Journal. 19: 5688-5700. PMID 34765089 DOI: 10.1016/j.csbj.2021.10.001 |
0.354 |
|
2021 |
Ratnapriya S, Harris M, Chov A, Herbert ZT, Vrbanac V, Deruaz M, Achuthan V, Engelman AN, Sodroski J, Herschhorn A. Intra- and extra-cellular environments contribute to the fate of HIV-1 infection. Cell Reports. 36: 109622. PMID 34469717 DOI: 10.1016/j.celrep.2021.109622 |
0.54 |
|
2021 |
Maehigashi T, Ahn S, Kim UI, Lindenberger J, Oo A, Koneru PC, Mahboubi B, Engelman AN, Kvaratskhelia M, Kim K, Kim B. A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site. Plos Pathogens. 17: e1009671. PMID 34293041 DOI: 10.1371/journal.ppat.1009671 |
0.478 |
|
2021 |
Maertens GN, Engelman AN, Cherepanov P. Structure and function of retroviral integrase. Nature Reviews. Microbiology. PMID 34244677 DOI: 10.1038/s41579-021-00586-9 |
0.425 |
|
2021 |
Bedwell GJ, Jang S, Li W, Singh PK, Engelman AN. rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration in vitro and in vivo. Nucleic Acids Research. PMID 34165568 DOI: 10.1093/nar/gkab514 |
0.453 |
|
2021 |
Zheng Y, Schubert HL, Singh PK, Martins LJ, Engelman AN, D'Orso I, Hill CP, Planelles V. Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal. Mbio. e0109821. PMID 34154414 DOI: 10.1128/mBio.01098-21 |
0.536 |
|
2021 |
Bedwell GJ, Engelman AN. You can keep your coat on. Elife. 10. PMID 34061028 DOI: 10.7554/eLife.69887 |
0.339 |
|
2021 |
Engelman KD, Engelman AN. Long-Acting Cabotegravir for HIV/AIDS Prophylaxis. Biochemistry. 60: 1731-1740. PMID 34029457 DOI: 10.1021/acs.biochem.1c00157 |
0.472 |
|
2021 |
Zhong Z, Ning J, Boggs EA, Jang S, Wallace C, Telmer C, Bruchez MP, Ahn J, Engelman AN, Zhang P, Watkins SC, Ambrose Z. Cytoplasmic CPSF6 Regulates HIV-1 Capsid Trafficking and Infection in a Cyclophilin A-Dependent Manner. Mbio. 12. PMID 33758083 DOI: 10.1128/mBio.03142-20 |
0.566 |
|
2021 |
Pandey KK, Bera S, Shi K, Rau MJ, Oleru AV, Fitzpatrick JAJ, Engelman AN, Aihara H, Grandgenett DP. Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome. Communications Biology. 4: 330. PMID 33712691 DOI: 10.1038/s42003-021-01855-2 |
0.37 |
|
2021 |
Engelman AN. HIV Capsid and Integration Targeting. Viruses. 13. PMID 33477441 DOI: 10.3390/v13010125 |
0.534 |
|
2020 |
Bedwell GJ, Engelman AN. Factors that mold the nuclear landscape of HIV-1 integration. Nucleic Acids Research. PMID 33337475 DOI: 10.1093/nar/gkaa1207 |
0.586 |
|
2020 |
Xu C, Fischer DK, Rankovic S, Li W, Dick RA, Runge B, Zadorozhnyi R, Ahn J, Aiken C, Polenova T, Engelman AN, Ambrose Z, Rousso I, Perilla JR. Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis. Plos Biology. 18: e3001015. PMID 33332391 DOI: 10.1371/journal.pbio.3001015 |
0.496 |
|
2020 |
Francis AC, Marin M, Singh PK, Achuthan V, Prellberg MJ, Palermino-Rowland K, Lan S, Tedbury PR, Sarafianos SG, Engelman AN, Melikyan GB. Publisher Correction: HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains. Nature Communications. 11: 6165. PMID 33244008 DOI: 10.1038/s41467-020-20152-w |
0.393 |
|
2020 |
Eschbach JE, Elliott JL, Li W, Zadrozny KK, Davis K, Mohammed SJ, Lawson DQ, Pornillos O, Engelman AN, Kutluay SB. Capsid lattice destabilization leads to premature loss of the viral genome and integrase enzyme during HIV-1 infection. Journal of Virology. PMID 33115869 DOI: 10.1128/JVI.00984-20 |
0.325 |
|
2020 |
Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, et al. Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science (New York, N.Y.). 370: 360-364. PMID 33060363 DOI: 10.1126/science.abb4808 |
0.523 |
|
2020 |
Li W, Singh PK, Sowd GA, Bedwell GJ, Jang S, Achuthan V, Oleru AV, Wong D, Fadel HJ, Lee K, KewalRamani VN, Poeschla EM, Herschhorn A, Engelman AN. CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration. Mbio. 11. PMID 32994325 DOI: 10.1128/mBio.02254-20 |
0.829 |
|
2020 |
Elliott JL, Eschbach JE, Koneru PC, Li W, Puray Chavez M, Townsend D, Lawson DQ, Engelman AN, Kvaratskhelia M, Kutluay SB. Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis. Elife. 9. PMID 32960169 DOI: 10.7554/Elife.54311 |
0.396 |
|
2020 |
Jiang C, Lian X, Gao C, Sun X, Einkauf KB, Chevalier JM, Chen SMY, Hua S, Rhee B, Chang K, Blackmer JE, Osborn M, Peluso MJ, Hoh R, Somsouk M, ... ... Engelman AN, et al. Distinct viral reservoirs in individuals with spontaneous control of HIV-1. Nature. PMID 32848246 DOI: 10.1038/S41586-020-2651-8 |
0.56 |
|
2020 |
Ni T, Gerard S, Zhao G, Dent K, Ning J, Zhou J, Shi J, Anderson-Daniels J, Li W, Jang S, Engelman AN, Aiken C, Zhang P. Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A. Nature Structural & Molecular Biology. PMID 32747784 DOI: 10.1038/S41594-020-0467-8 |
0.352 |
|
2020 |
Francis AC, Marin M, Singh PK, Achuthan V, Prellberg MJ, Palermino-Rowland K, Lan S, Tedbury PR, Sarafianos SG, Engelman AN, Melikyan GB. HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains. Nature Communications. 11: 3505. PMID 32665593 DOI: 10.1038/S41467-020-17256-8 |
0.611 |
|
2020 |
Engelman AN, Cherepanov P. Close-up: HIV/SIV intasome structures shed new light on integrase inhibitor binding and viral escape mechanisms. The Febs Journal. PMID 32506843 DOI: 10.1111/Febs.15438 |
0.55 |
|
2020 |
Chaudhuri E, Dash S, Balasubramaniam M, Padron A, Holland J, Sowd G, Villalta F, Engelman AN, Pandhare J, Dash C. The HIV-1 capsid-binding host factor CPSF6 is post-transcriptionally regulated by the cellular microRNA miR-125b. The Journal of Biological Chemistry. PMID 32152226 DOI: 10.1074/Jbc.Ra119.010534 |
0.745 |
|
2020 |
Li M, Chen X, Wang H, Jurado KA, Engelman AN, Craigie R. A peptide derived from lens epithelium-derived growth factor stimulates HIV-1 DNA integration and facilitates intasome structural studies. Journal of Molecular Biology. PMID 32061936 DOI: 10.1016/J.Jmb.2020.01.040 |
0.565 |
|
2020 |
Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P. Structural basis of second-generation HIV integrase inhibitor action and viral resistance. Science (New York, N.Y.). PMID 32001525 DOI: 10.1126/Science.Aay4919 |
0.536 |
|
2020 |
Li M, Chen X, Wang H, Jurado K, Engelman A, Craigie R. A peptide derived from LEDGF stimulates HIV-1 DNA integration and facilitates intasome structural studies Journal of Molecular Biology. DOI: 10.2210/Pdb6U8Q/Pdb |
0.474 |
|
2020 |
Chaudhuri E, Dash S, Balasubramaniam M, Holland OL, Sowd G, Villalta F, Engelman A, Pandhare J, Dash C. HIV‐1 Capsid Binding Host Factor CPSF6 is Post Transcriptionally Regulated by the Cellular MicroRNA miR‐125b The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03027 |
0.737 |
|
2019 |
Loyola L, Achuthan V, Gilroy K, Borland G, Kilbey A, Mackay N, Bell M, Hay J, Aiyer S, Fingerman D, Villanueva RA, Cameron E, Kozak CA, Engelman AN, Neil J, et al. Disrupting MLV integrase:BET protein interaction biases integration into quiescent chromatin and delays but does not eliminate tumor activation in a MYC/Runx2 mouse model. Plos Pathogens. 15: e1008154. PMID 31815961 DOI: 10.1371/Journal.Ppat.1008154 |
0.411 |
|
2019 |
Engelman AN. Multifaceted HIV integrase functionalities and therapeutic strategies for their inhibition. The Journal of Biological Chemistry. PMID 31467082 DOI: 10.1074/Jbc.Rev119.006901 |
0.615 |
|
2019 |
Achuthan V, Perreira JM, Ahn JJ, Brass AL, Engelman AN. Capsid-CPSF6 interaction: Master regulator of nuclear HIV-1 positioning and integration. Journal of Life Sciences (Westlake Village, Calif.). 1: 39-45. PMID 31448372 DOI: 10.36069/jols/20190604 |
0.541 |
|
2019 |
Anderson-Daniels J, Singh PK, Sowd GA, Li W, Engelman AN, Aiken C. Dominant negative MA-CA fusion protein is incorporated into HIV-1 cores and inhibits nuclear entry of viral preintegration complexes. Journal of Virology. PMID 31413124 DOI: 10.1128/Jvi.01118-19 |
0.813 |
|
2019 |
Zhang DW, Luo RH, Xu L, Yang LM, Xu XS, Bedwell GJ, Engelman AN, Zheng YT, Chang S. A HTRF based competitive binding assay for screening specific inhibitors of HIV-1 capsid assembly targeting the C-Terminal domain of capsid. Antiviral Research. 104544. PMID 31254557 DOI: 10.1016/J.Antiviral.2019.104544 |
0.476 |
|
2019 |
Koneru PC, Francis AC, Deng N, Rebensburg SV, Hoyte AC, Lindenberger J, Adu-Ampratwum D, Larue RC, Wempe MF, Engelman AN, Lyumkis D, Fuchs JR, Levy RM, Melikyan GB, Kvaratskhelia M. HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. Elife. 8. PMID 31120420 DOI: 10.7554/Elife.46344 |
0.609 |
|
2019 |
Jang S, Cook NJ, Pye VE, Bedwell GJ, Dudek AM, Singh PK, Cherepanov P, Engelman AN. Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6. Nucleic Acids Research. PMID 30916345 DOI: 10.1093/Nar/Gkz206 |
0.372 |
|
2019 |
Koneru PC, Francis AC, Deng N, Rebensburg SV, Hoyte AC, Lindenberger J, Adu-Ampratwum D, Larue RC, Wempe MF, Engelman AN, Lyumkis D, Fuchs JR, Levy RM, Melikyan GB, Kvaratskhelia M. Author response: HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors Elife. DOI: 10.7554/Elife.46344.029 |
0.516 |
|
2018 |
Achuthan V, Perreira JM, Sowd GA, Puray-Chavez M, McDougall WM, Paulucci-Holthauzen A, Wu X, Fadel HJ, Poeschla EM, Multani AS, Hughes SH, Sarafianos SG, Brass AL, Engelman AN. Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration. Cell Host & Microbe. PMID 30173955 DOI: 10.1016/J.Chom.2018.08.002 |
0.846 |
|
2018 |
Engelman AN, Singh PK. Cellular and molecular mechanisms of HIV-1 integration targeting. Cellular and Molecular Life Sciences : Cmls. 75: 2491-2507. PMID 29417178 DOI: 10.1007/S00018-018-2772-5 |
0.612 |
|
2018 |
Zhu Y, Wang X, Forouzmand E, Jeong J, Qiao F, Sowd GA, Engelman AN, Xie X, Hertel KJ, Shi Y. Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation. Molecular Cell. 69: 62-74.e4. PMID 29276085 DOI: 10.1016/J.Molcel.2017.11.031 |
0.745 |
|
2018 |
El Ashkar S, Schwaller J, Pieters T, Goossens S, Demeulemeester J, Christ F, Van Belle S, Juge S, Boeckx N, Engelman A, Van Vlierberghe P, Debyser Z, De Rijck J. LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis. Blood. 131: 95-107. PMID 29084774 DOI: 10.1182/Blood-2017-05-786962 |
0.328 |
|
2018 |
Engelman A, Towers GJ. Decision letter: HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex Elife. DOI: 10.7554/Elife.41800.030 |
0.478 |
|
2017 |
Puray-Chavez M, Tedbury PR, Huber AD, Ukah OB, Yapo V, Liu D, Ji J, Wolf JJ, Engelman AN, Sarafianos SG. Multiplex single-cell visualization of nucleic acids and protein during HIV infection. Nature Communications. 8: 1882. PMID 29192235 DOI: 10.1038/S41467-017-01693-Z |
0.546 |
|
2017 |
Hoyte AC, Jamin AV, Koneru PC, Kobe MJ, Larue RC, Fuchs JR, Engelman AN, Kvaratskhelia M. Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing. The Journal of Biological Chemistry. 292: 19814-19825. PMID 28972144 DOI: 10.1074/Jbc.M117.816645 |
0.594 |
|
2017 |
Alvarez FJD, He S, Perilla JR, Jang S, Schulten K, Engelman AN, Scheres SHW, Zhang P. CryoEM structure of MxB reveals a novel oligomerization interface critical for HIV restriction. Science Advances. 3: e1701264. PMID 28929138 DOI: 10.1126/Sciadv.1701264 |
0.51 |
|
2017 |
Yamashita M, Engelman AN. Capsid-Dependent Host Factors in HIV-1 Infection. Trends in Microbiology. 25: 741-755. PMID 28528781 DOI: 10.1016/J.Tim.2017.04.004 |
0.606 |
|
2017 |
Lesbats P, Serrao E, Maskell DP, Pye VE, O'Reilly N, Lindemann D, Engelman AN, Cherepanov P. Structural basis for spumavirus GAG tethering to chromatin. Proceedings of the National Academy of Sciences of the United States of America. 114: 5509-5514. PMID 28490494 DOI: 10.1073/Pnas.1621159114 |
0.423 |
|
2017 |
Engelman AN, Cherepanov P. Retroviral intasomes arising. Current Opinion in Structural Biology. 47: 23-29. PMID 28458055 DOI: 10.1016/J.Sbi.2017.04.005 |
0.334 |
|
2017 |
Grawenhoff J, Engelman AN. Retroviral integrase protein and intasome nucleoprotein complex structures. World Journal of Biological Chemistry. 8: 32-44. PMID 28289517 DOI: 10.4331/Wjbc.V8.I1.32 |
0.422 |
|
2017 |
Wang W, Zhou J, Halambage UD, Jurado KA, Jamin AV, Wang Y, Engelman AN, Aiken C. Inhibition of HIV-1 Maturation via Small-Molecule Targeting of the Amino-Terminal Domain in the Viral Capsid Protein. Journal of Virology. 91. PMID 28202766 DOI: 10.1128/Jvi.02155-16 |
0.624 |
|
2017 |
Ballandras-Colas A, Maskell DP, Serrao E, Locke J, Swuec P, Jónsson SR, Kotecha A, Cook NJ, Pye VE, Taylor IA, Andrésdóttir V, Engelman AN, Costa A, Cherepanov P. A supramolecular assembly mediates lentiviral DNA integration. Science (New York, N.Y.). 355: 93-95. PMID 28059770 DOI: 10.1126/Science.Aah7002 |
0.55 |
|
2016 |
Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. The Journal of Biological Chemistry. 291: 23569-23577. PMID 27645997 DOI: 10.1074/Jbc.M116.753384 |
0.582 |
|
2016 |
Zurnic I, Hütter S, Rzeha U, Stanke N, Reh J, Müllers E, Hamann MV, Kern T, Gerresheim GK, Lindel F, Serrao E, Lesbats P, Engelman AN, Cherepanov P, Lindemann D. Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration. Plos Pathogens. 12: e1005860. PMID 27579920 DOI: 10.1371/Journal.Ppat.1005860 |
0.482 |
|
2016 |
Deng N, Hoyte A, Mansour YE, Mohamed MS, Fuchs JR, Engelman AN, Kvaratskhelia M, Levy R. Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies. Protein Science : a Publication of the Protein Society. 25: 1911-1917. PMID 27503276 DOI: 10.1002/Pro.2997 |
0.477 |
|
2016 |
Zerbato JM, Serrao E, Lenzi G, Kim B, Ambrose Z, Watkins SC, Engelman AN, Sluis-Cremer N. Establishment and Reversal of HIV-1 Latency in Naive and Central Memory CD4+ T Cells In Vitro. Journal of Virology. 90: 8059-73. PMID 27356901 DOI: 10.1128/Jvi.00553-16 |
0.526 |
|
2016 |
Saito A, Henning MS, Serrao E, Dubose BN, Teng S, Huang J, Li X, Saito N, Roy SP, Siddiqui MA, Ahn J, Tsuji M, Hatziioannou T, Engelman AN, Yamashita M. Capsid-CPSF6 Interaction Is Dispensable for HIV-1 Replication in Primary Cells but Is Selected during Virus Passage In Vivo. Journal of Virology. 90: 6918-6935. PMID 27307565 DOI: 10.1128/Jvi.00019-16 |
0.609 |
|
2016 |
Lesbats P, Engelman AN, Cherepanov P. Retroviral DNA Integration. Chemical Reviews. 116: 12730-12757. PMID 27198982 DOI: 10.1021/Acs.Chemrev.6B00125 |
0.421 |
|
2016 |
Saito A, Ferhadian D, Sowd GA, Serrao E, Shi J, Halambage UD, Teng S, Soto J, Siddiqui MA, Engelman AN, Aiken C, Yamashita M. Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74. Journal of Virology. 90: 5808-5823. PMID 27076642 DOI: 10.1128/Jvi.03116-15 |
0.807 |
|
2016 |
Serrao E, Cherepanov P, Engelman AN. Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites. Journal of Visualized Experiments : Jove. PMID 27023428 DOI: 10.3791/53840 |
0.382 |
|
2016 |
Rasheedi S, Shun MC, Serrao E, Sowd GA, Qian J, Hao C, Dasgupta T, Engelman AN, Skowronski J. The Cleavage and Polyadenylation Specificity Factor 6 (CPSF6) Subunit of the Capsid-recruited Pre-messenger RNA Cleavage Factor I (CFIm) Complex Mediates HIV-1 Integration into Genes. The Journal of Biological Chemistry. 291: 11809-19. PMID 26994143 DOI: 10.1074/Jbc.M116.721647 |
0.841 |
|
2016 |
Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M. The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency. Acs Chemical Biology. 11: 1313-21. PMID 26910179 DOI: 10.1021/Acschembio.6B00167 |
0.599 |
|
2016 |
Ballandras-Colas A, Brown M, Cook NJ, Dewdney TG, Demeler B, Cherepanov P, Lyumkis D, Engelman AN. Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature. 530: 358-61. PMID 26887496 DOI: 10.1038/Nature16955 |
0.438 |
|
2016 |
Sowd GA, Serrao E, Wang H, Wang W, Fadel HJ, Poeschla EM, Engelman AN. A critical role for alternative polyadenylation factor CPSF6 in targeting HIV-1 integration to transcriptionally active chromatin. Proceedings of the National Academy of Sciences of the United States of America. 113: E1054-63. PMID 26858452 DOI: 10.1073/Pnas.1524213113 |
0.822 |
|
2016 |
Serrao E, Engelman AN. Sites of retroviral DNA integration: From basic research to clinical applications. Critical Reviews in Biochemistry and Molecular Biology. 51: 26-42. PMID 26508664 DOI: 10.3109/10409238.2015.1102859 |
0.474 |
|
2016 |
Fontana J, Jurado KA, Cheng N, Engelman AN, Steven AC. Cryo-Electron Tomography and Nucleocapsid Protein Labeling by Tomo-Bubblegram Imaging Reveal a Role for HIV-1 Integrase in Viral Maturation Biophysical Journal. 110: 155a. DOI: 10.1016/J.Bpj.2015.11.873 |
0.506 |
|
2015 |
Nuñez JK, Harrington LB, Kranzusch PJ, Engelman AN, Doudna JA. Foreign DNA capture during CRISPR-Cas adaptive immunity. Nature. 527: 535-8. PMID 26503043 DOI: 10.1038/Nature15760 |
0.353 |
|
2015 |
Fontana J, Jurado KA, Cheng N, Ly NL, Fuchs JR, Gorelick RJ, Engelman AN, Steven AC. Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation. Journal of Virology. 89: 9765-80. PMID 26178982 DOI: 10.1128/Jvi.01522-15 |
0.542 |
|
2015 |
Maskell DP, Renault L, Serrao E, Lesbats P, Matadeen R, Hare S, Lindemann D, Engelman AN, Costa A, Cherepanov P. Structural basis for retroviral integration into nucleosomes. Nature. 523: 366-9. PMID 26061770 DOI: 10.1038/Nature14495 |
0.387 |
|
2015 |
Serrao E, Ballandras-Colas A, Cherepanov P, Maertens GN, Engelman AN. Key determinants of target DNA recognition by retroviral intasomes. Retrovirology. 12: 39. PMID 25924943 DOI: 10.1186/S12977-015-0167-3 |
0.537 |
|
2015 |
Nuñez JK, Lee AS, Engelman A, Doudna JA. Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity. Nature. 519: 193-8. PMID 25707795 DOI: 10.1038/Nature14237 |
0.33 |
|
2015 |
Fontana J, Jurado KA, Cheng N, Engelman A, Steven AC. Exploiting the Susceptibility of HIV-1 Nucleocapsid Protein to Radiation Damage in Tomo-Bubblegram Imaging Microscopy and Microanalysis. 21: 545-546. DOI: 10.1017/S1431927615003529 |
0.458 |
|
2014 |
Engelman A, Cherepanov P. Retroviral Integrase Structure and DNA Recombination Mechanism. Microbiology Spectrum. 2. PMID 26104441 DOI: 10.1128/Microbiolspec.Mdna3-0024-2014 |
0.466 |
|
2014 |
Engelman A, Cherepanov P. Retroviral Integrase Structure and DNA Recombination Mechanism. Microbiology Spectrum. 2: 1-22. PMID 25705574 DOI: 10.1128/microbiolspec.MDNA3-0024-2014. |
0.362 |
|
2014 |
Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology. 11: 100. PMID 25421939 DOI: 10.1186/S12977-014-0100-1 |
0.544 |
|
2014 |
Wang H, Shun MC, Li X, Di Nunzio F, Hare S, Cherepanov P, Engelman A. Efficient Transduction of LEDGF/p75 Mutant Cells by Gain-of-Function HIV-1 Integrase Mutant Viruses. Molecular Therapy. Methods & Clinical Development. 1. PMID 25383358 DOI: 10.1038/Mtm.2013.2 |
0.528 |
|
2014 |
Matreyek KA, Wang W, Serrao E, Singh PK, Levin HL, Engelman A. Host and viral determinants for MxB restriction of HIV-1 infection. Retrovirology. 11: 90. PMID 25348155 DOI: 10.1186/S12977-014-0090-Z |
0.798 |
|
2014 |
Fribourgh JL, Nguyen HC, Matreyek KA, Alvarez FJD, Summers BJ, Dewdney TG, Aiken C, Zhang P, Engelman A, Xiong Y. Structural insight into HIV-1 restriction by MxB. Cell Host & Microbe. 16: 627-638. PMID 25312384 DOI: 10.1016/J.Chom.2014.09.021 |
0.818 |
|
2014 |
Kvaratskhelia M, Sharma A, Larue RC, Serrao E, Engelman A. Molecular mechanisms of retroviral integration site selection. Nucleic Acids Research. 42: 10209-25. PMID 25147212 DOI: 10.1093/Nar/Gku769 |
0.56 |
|
2014 |
Li M, Jurado KA, Lin S, Engelman A, Craigie R. Engineered hyperactive integrase for concerted HIV-1 DNA integration. Plos One. 9: e105078. PMID 25119883 DOI: 10.1371/Journal.Pone.0105078 |
0.612 |
|
2014 |
Serrao E, Krishnan L, Shun MC, Li X, Cherepanov P, Engelman A, Maertens GN. Integrase residues that determine nucleotide preferences at sites of HIV-1 integration: implications for the mechanism of target DNA binding. Nucleic Acids Research. 42: 5164-76. PMID 24520116 DOI: 10.1093/Nar/Gku136 |
0.589 |
|
2014 |
Maertens GN, Cook NJ, Wang W, Hare S, Gupta SS, Öztop I, Lee K, Pye VE, Cosnefroy O, Snijders AP, KewalRamani VN, Fassati A, Engelman A, Cherepanov P. Structural basis for nuclear import of splicing factors by human Transportin 3. Proceedings of the National Academy of Sciences of the United States of America. 111: 2728-33. PMID 24449914 DOI: 10.1073/Pnas.1320755111 |
0.719 |
|
2013 |
Jurado KA, Engelman A. Multimodal mechanism of action of allosteric HIV-1 integrase inhibitors. Expert Reviews in Molecular Medicine. 15: e14. PMID 24274067 DOI: 10.1017/Erm.2013.15 |
0.648 |
|
2013 |
Matreyek KA, Yücel SS, Li X, Engelman A. Nucleoporin NUP153 phenylalanine-glycine motifs engage a common binding pocket within the HIV-1 capsid protein to mediate lentiviral infectivity. Plos Pathogens. 9: e1003693. PMID 24130490 DOI: 10.1371/Journal.Ppat.1003693 |
0.796 |
|
2013 |
Ballandras-Colas A, Naraharisetty H, Li X, Serrao E, Engelman A. Biochemical characterization of novel retroviral integrase proteins. Plos One. 8: e76638. PMID 24124581 DOI: 10.1371/Journal.Pone.0076638 |
0.42 |
|
2013 |
Matreyek KA, Engelman A. Viral and cellular requirements for the nuclear entry of retroviral preintegration nucleoprotein complexes. Viruses. 5: 2483-511. PMID 24103892 DOI: 10.3390/V5102483 |
0.805 |
|
2013 |
Engelman A, Kessl JJ, Kvaratskhelia M. Allosteric inhibition of HIV-1 integrase activity. Current Opinion in Chemical Biology. 17: 339-45. PMID 23647983 DOI: 10.1016/J.Cbpa.2013.04.010 |
0.564 |
|
2013 |
Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M. The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors. The Journal of Biological Chemistry. 288: 15813-20. PMID 23615903 DOI: 10.1074/Jbc.M112.443390 |
0.558 |
|
2013 |
Jurado KA, Wang H, Slaughter A, Feng L, Kessl JJ, Koh Y, Wang W, Ballandras-Colas A, Patel PA, Fuchs JR, Kvaratskhelia M, Engelman A. Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation. Proceedings of the National Academy of Sciences of the United States of America. 110: 8690-5. PMID 23610442 DOI: 10.1073/Pnas.1300703110 |
0.608 |
|
2013 |
Koh Y, Ballana E, Este J, Engelman A. Polymorphic LEDGF/p75 variants support efficient HIV-1 infection ex vivo. Aids (London, England). 27: 665-7. PMID 23364444 DOI: 10.1097/Qad.0B013E32835Af34C |
0.602 |
|
2013 |
Koh Y, Wu X, Ferris AL, Matreyek KA, Smith SJ, Lee K, KewalRamani VN, Hughes SH, Engelman A. Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration. Journal of Virology. 87: 648-58. PMID 23097450 DOI: 10.1128/Jvi.01148-12 |
0.812 |
|
2013 |
Shah VB, Shi J, Hout DR, Oztop I, Krishnan L, Ahn J, Shotwell MS, Engelman A, Aiken C. The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating. Journal of Virology. 87: 422-32. PMID 23097435 DOI: 10.1128/Jvi.07177-11 |
0.798 |
|
2012 |
Krishnan L, Engelman A. Retroviral integrase proteins and HIV-1 DNA integration. The Journal of Biological Chemistry. 287: 40858-66. PMID 23043109 DOI: 10.1074/Jbc.R112.397760 |
0.568 |
|
2012 |
Wang H, Jurado KA, Wu X, Shun MC, Li X, Ferris AL, Smith SJ, Patel PA, Fuchs JR, Cherepanov P, Kvaratskhelia M, Hughes SH, Engelman A. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Research. 40: 11518-30. PMID 23042676 DOI: 10.1093/Nar/Gks913 |
0.511 |
|
2012 |
Matreyek KA, Oztop I, Freed EO, Engelman A. Viral latency and potential eradication of HIV-1. Expert Review of Anti-Infective Therapy. 10: 855-7. PMID 23030323 DOI: 10.1586/Eri.12.68 |
0.841 |
|
2012 |
Kessl JJ, Jena N, Koh Y, Taskent-Sezgin H, Slaughter A, Feng L, de Silva S, Wu L, Le Grice SF, Engelman A, Fuchs JR, Kvaratskhelia M. Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors. The Journal of Biological Chemistry. 287: 16801-11. PMID 22437836 DOI: 10.1074/Jbc.M112.354373 |
0.594 |
|
2012 |
Engelman A, Cherepanov P. The structural biology of HIV-1: mechanistic and therapeutic insights. Nature Reviews. Microbiology. 10: 279-90. PMID 22421880 DOI: 10.1038/Nrmicro2747 |
0.558 |
|
2012 |
Ambrose Z, Lee K, Ndjomou J, Xu H, Oztop I, Matous J, Takemura T, Unutmaz D, Engelman A, Hughes SH, KewalRamani VN. Human immunodeficiency virus type 1 capsid mutation N74D alters cyclophilin A dependence and impairs macrophage infection. Journal of Virology. 86: 4708-14. PMID 22301145 DOI: 10.1128/Jvi.05887-11 |
0.791 |
|
2012 |
Li X, Koh Y, Engelman A. Correlation of recombinant integrase activity and functional preintegration complex formation during acute infection by replication-defective integrase mutant human immunodeficiency virus. Journal of Virology. 86: 3861-79. PMID 22278243 DOI: 10.1128/Jvi.06386-11 |
0.545 |
|
2011 |
Matreyek KA, Engelman A. The requirement for nucleoporin NUP153 during human immunodeficiency virus type 1 infection is determined by the viral capsid. Journal of Virology. 85: 7818-27. PMID 21593146 DOI: 10.1128/Jvi.00325-11 |
0.827 |
|
2011 |
Yan N, O'Day E, Wheeler LA, Engelman A, Lieberman J. HIV DNA is heavily uracilated, which protects it from autointegration. Proceedings of the National Academy of Sciences of the United States of America. 108: 9244-9. PMID 21576478 DOI: 10.1073/Pnas.1102943108 |
0.62 |
|
2011 |
Zamborlini A, Coiffic A, Beauclair G, Delelis O, Paris J, Koh Y, Magne F, Giron ML, Tobaly-Tapiero J, Deprez E, Emiliani S, Engelman A, de Thé H, Saïb A. Impairment of human immunodeficiency virus type-1 integrase SUMOylation correlates with an early replication defect. The Journal of Biological Chemistry. 286: 21013-22. PMID 21454548 DOI: 10.1074/Jbc.M110.189274 |
0.643 |
|
2011 |
Koh Y, Matreyek KA, Engelman A. Differential sensitivities of retroviruses to integrase strand transfer inhibitors. Journal of Virology. 85: 3677-82. PMID 21270168 DOI: 10.1128/Jvi.02541-10 |
0.786 |
|
2011 |
Li X, Krishnan L, Cherepanov P, Engelman A. Structural biology of retroviral DNA integration. Virology. 411: 194-205. PMID 21216426 DOI: 10.1016/J.Virol.2010.12.008 |
0.497 |
|
2011 |
Koh Y, Haim H, Engelman A. Identification and characterization of persistent intracellular human immunodeficiency virus type 1 integrase strand transfer inhibitor activity. Antimicrobial Agents and Chemotherapy. 55: 42-9. PMID 21060108 DOI: 10.1128/Aac.01064-10 |
0.513 |
|
2011 |
Zamborlini A, Coiffic A, Beauclair G, Delelis O, Paris J, Magne F, Koh Y, Giron M, Tobaly-Tapiero J, Emiliani S, Engelman A, de The H, Saib A. HIV-1 integrase SUMOylation and viral replication Retrovirology. 8. DOI: 10.1186/1742-4690-8-S2-O4 |
0.665 |
|
2011 |
Engelman A. Pleiotropic Nature of HIV-1 Integrase Mutations Hiv-1 Integrase: Mechanism and Inhibitor Design. 67-81. DOI: 10.1002/9781118015377.ch6 |
0.413 |
|
2010 |
Krishnan L, Li X, Naraharisetty HL, Hare S, Cherepanov P, Engelman A. Structure-based modeling of the functional HIV-1 intasome and its inhibition. Proceedings of the National Academy of Sciences of the United States of America. 107: 15910-5. PMID 20733078 DOI: 10.1073/Pnas.1002346107 |
0.568 |
|
2010 |
Lee K, Ambrose Z, Martin TD, Oztop I, Mulky A, Julias JG, Vandegraaff N, Baumann JG, Wang R, Yuen W, Takemura T, Shelton K, Taniuchi I, Li Y, Sodroski J, ... ... Engelman A, et al. Flexible use of nuclear import pathways by HIV-1. Cell Host & Microbe. 7: 221-33. PMID 20227665 DOI: 10.1016/J.Chom.2010.02.007 |
0.791 |
|
2010 |
Ferris AL, Wu X, Hughes CM, Stewart C, Smith SJ, Milne TA, Wang GG, Shun MC, Allis CD, Engelman A, Hughes SH. Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration. Proceedings of the National Academy of Sciences of the United States of America. 107: 3135-40. PMID 20133638 DOI: 10.1073/Pnas.0914142107 |
0.534 |
|
2010 |
Hare S, Gupta SS, Valkov E, Engelman A, Cherepanov P. Retroviral intasome assembly and inhibition of DNA strand transfer. Nature. 464: 232-6. PMID 20118915 DOI: 10.1038/Nature08784 |
0.51 |
|
2010 |
Hughes S, Jenkins V, Dar MJ, Engelman A, Cherepanov P. Transcriptional co-activator LEDGF interacts with Cdc7-activator of S-phase kinase (ASK) and stimulates its enzymatic activity. The Journal of Biological Chemistry. 285: 541-54. PMID 19864417 DOI: 10.1074/Jbc.M109.036491 |
0.327 |
|
2010 |
Krishnan L, Matreyek KA, Oztop I, Lee K, Tipper CH, Li X, Dar MJ, Kewalramani VN, Engelman A. The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase. Journal of Virology. 84: 397-406. PMID 19846519 DOI: 10.1128/Jvi.01899-09 |
0.857 |
|
2009 |
Dar MJ, Monel B, Krishnan L, Shun MC, Di Nunzio F, Helland DE, Engelman A. Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase. Retrovirology. 6: 94. PMID 19840380 DOI: 10.1186/1742-4690-6-94 |
0.619 |
|
2009 |
Hare S, Di Nunzio F, Labeja A, Wang J, Engelman A, Cherepanov P. Structural basis for functional tetramerization of lentiviral integrase. Plos Pathogens. 5: e1000515. PMID 19609359 DOI: 10.1371/Journal.Ppat.1000515 |
0.458 |
|
2009 |
Belshan M, Schweitzer CJ, Donnellan MR, Lu R, Engelman A. In vivo biotinylation and capture of HIV-1 matrix and integrase proteins. Journal of Virological Methods. 159: 178-84. PMID 19490971 DOI: 10.1016/J.Jviromet.2009.03.017 |
0.755 |
|
2009 |
Engelman A. Mechanistic and pharmacological analyses of HIV-1 integration. Methods (San Diego, Calif.). 47: 225-8. PMID 19389610 DOI: 10.1016/J.Ymeth.2009.03.018 |
0.624 |
|
2009 |
Yan N, Cherepanov P, Daigle JE, Engelman A, Lieberman J. The SET complex acts as a barrier to autointegration of HIV-1. Plos Pathogens. 5: e1000327. PMID 19266025 DOI: 10.1371/Journal.Ppat.1000327 |
0.592 |
|
2009 |
Engelman A, Oztop I, Vandegraaff N, Raghavendra NK. Quantitative analysis of HIV-1 preintegration complexes. Methods (San Diego, Calif.). 47: 283-90. PMID 19233280 DOI: 10.1016/J.Ymeth.2009.02.005 |
0.724 |
|
2009 |
Hare S, Shun MC, Gupta SS, Valkov E, Engelman A, Cherepanov P. A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75. Plos Pathogens. 5: e1000259. PMID 19132083 DOI: 10.1371/Journal.Ppat.1000259 |
0.552 |
|
2009 |
Engelman A. Isolation and analysis of HIV-1 preintegration complexes. Methods in Molecular Biology (Clifton, N.J.). 485: 135-49. PMID 19020823 DOI: 10.1007/978-1-59745-170-3_10 |
0.647 |
|
2008 |
McKee CJ, Kessl JJ, Shkriabai N, Dar MJ, Engelman A, Kvaratskhelia M. Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein. The Journal of Biological Chemistry. 283: 31802-12. PMID 18801737 DOI: 10.1074/Jbc.M805843200 |
0.539 |
|
2008 |
Shun MC, Botbol Y, Li X, Di Nunzio F, Daigle JE, Yan N, Lieberman J, Lavigne M, Engelman A. Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity. Journal of Virology. 82: 11555-67. PMID 18799576 DOI: 10.1128/Jvi.01561-08 |
0.523 |
|
2008 |
Engelman A, Cherepanov P. The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication. Plos Pathogens. 4: e1000046. PMID 18369482 DOI: 10.1371/Journal.Ppat.1000046 |
0.596 |
|
2008 |
Brass AL, Dykxhoorn DM, Benita Y, Yan N, Engelman A, Xavier RJ, Lieberman J, Elledge SJ. Identification of host proteins required for HIV infection through a functional genomic screen. Science (New York, N.Y.). 319: 921-6. PMID 18187620 DOI: 10.1126/Science.1152725 |
0.605 |
|
2008 |
Botbol Y, Raghavendra NK, Rahman S, Engelman A, Lavigne M. Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro. Nucleic Acids Research. 36: 1237-46. PMID 18174227 DOI: 10.1093/Nar/Gkm1127 |
0.581 |
|
2008 |
Zhao Z, McKee CJ, Kessl JJ, Santos WL, Daigle JE, Engelman A, Verdine G, Kvaratskhelia M. Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding. The Journal of Biological Chemistry. 283: 5632-41. PMID 18093980 DOI: 10.1074/Jbc.M705241200 |
0.508 |
|
2007 |
Shun MC, Raghavendra NK, Vandegraaff N, Daigle JE, Hughes S, Kellam P, Cherepanov P, Engelman A. LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration. Genes & Development. 21: 1767-78. PMID 17639082 DOI: 10.1101/Gad.1565107 |
0.608 |
|
2007 |
Engelman A. AIDS/HIV. A reversal of fortune in HIV-1 integration. Science (New York, N.Y.). 316: 1855-7. PMID 17600205 DOI: 10.1126/Science.1145015 |
0.596 |
|
2007 |
Mbisa JL, Barr R, Thomas JA, Vandegraaff N, Dorweiler IJ, Svarovskaia ES, Brown WL, Mansky LM, Gorelick RJ, Harris RS, Engelman A, Pathak VK. Human immunodeficiency virus type 1 cDNAs produced in the presence of APOBEC3G exhibit defects in plus-strand DNA transfer and integration. Journal of Virology. 81: 7099-110. PMID 17428871 DOI: 10.1128/Jvi.00272-07 |
0.508 |
|
2007 |
Vandegraaff N, Engelman A. Molecular mechanisms of HIV integration and therapeutic intervention. Expert Reviews in Molecular Medicine. 9: 1-19. PMID 17320002 DOI: 10.1017/S1462399407000257 |
0.62 |
|
2007 |
Daelemans D, Lu R, De Clercq E, Engelman A. Characterization of a replication-competent, integrase-defective human immunodeficiency virus (HIV)/simian virus 40 chimera as a powerful tool for the discovery and validation of HIV integrase inhibitors. Journal of Virology. 81: 4381-5. PMID 17287285 DOI: 10.1128/Jvi.02637-06 |
0.757 |
|
2007 |
Raghavendra NK, Engelman A. LEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: implications for the mechanism of viral cDNA integration. Virology. 360: 1-5. PMID 17258258 DOI: 10.1016/J.Virol.2006.12.022 |
0.498 |
|
2007 |
Shun MC, Daigle JE, Vandegraaff N, Engelman A. Wild-type levels of human immunodeficiency virus type 1 infectivity in the absence of cellular emerin protein. Journal of Virology. 81: 166-72. PMID 17035312 DOI: 10.1128/Jvi.01953-06 |
0.628 |
|
2007 |
Rahman S, Lu R, Vandegraaff N, Cherepanov P, Engelman A. Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness. Virology. 357: 79-90. PMID 16959283 DOI: 10.1016/J.Virol.2006.08.011 |
0.742 |
|
2007 |
Engelman A. Host cell factors and HIV-1 integration Future Hiv Therapy. 1: 415-426. DOI: 10.2217/17469600.1.4.415 |
0.471 |
|
2006 |
Anderson JL, Campbell EM, Wu X, Vandegraaff N, Engelman A, Hope TJ. Proteasome inhibition reveals that a functional preintegration complex intermediate can be generated during restriction by diverse TRIM5 proteins. Journal of Virology. 80: 9754-60. PMID 16973579 DOI: 10.1128/Jvi.01052-06 |
0.59 |
|
2006 |
Maertens GN, Cherepanov P, Engelman A. Transcriptional co-activator p75 binds and tethers the Myc-interacting protein JPO2 to chromatin. Journal of Cell Science. 119: 2563-71. PMID 16735438 DOI: 10.1242/Jcs.02995 |
0.418 |
|
2006 |
Diaz-Griffero F, Vandegraaff N, Li Y, McGee-Estrada K, Stremlau M, Welikala S, Si Z, Engelman A, Sodroski J. Requirements for capsid-binding and an effector function in TRIMCyp-mediated restriction of HIV-1. Virology. 351: 404-19. PMID 16650449 DOI: 10.1016/J.Virol.2006.03.023 |
0.619 |
|
2006 |
Si Z, Vandegraaff N, O'huigin C, Song B, Yuan W, Xu C, Perron M, Li X, Marasco WA, Engelman A, Dean M, Sodroski J. Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection. Proceedings of the National Academy of Sciences of the United States of America. 103: 7454-9. PMID 16648259 DOI: 10.1073/Pnas.0600771103 |
0.426 |
|
2006 |
Turlure F, Maertens G, Rahman S, Cherepanov P, Engelman A. A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo. Nucleic Acids Research. 34: 1653-65. PMID 16549878 DOI: 10.1093/Nar/Gkl052 |
0.448 |
|
2006 |
Vandegraaff N, Devroe E, Turlure F, Silver PA, Engelman A. Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication. Virology. 346: 415-26. PMID 16337983 DOI: 10.1016/J.Virol.2005.11.022 |
0.62 |
|
2005 |
Cherepanov P, Ambrosio AL, Rahman S, Ellenberger T, Engelman A. Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75. Proceedings of the National Academy of Sciences of the United States of America. 102: 17308-13. PMID 16260736 DOI: 10.1073/Pnas.0506924102 |
0.598 |
|
2005 |
Lu R, Vandegraaff N, Cherepanov P, Engelman A. Lys-34, dispensable for integrase catalysis, is required for preintegration complex function and human immunodeficiency virus type 1 replication. Journal of Virology. 79: 12584-91. PMID 16160186 DOI: 10.1128/Jvi.79.19.12584-12591.2005 |
0.78 |
|
2005 |
Lu R, Ghory HZ, Engelman A. Genetic analyses of conserved residues in the carboxyl-terminal domain of human immunodeficiency virus type 1 integrase. Journal of Virology. 79: 10356-68. PMID 16051828 DOI: 10.1128/Jvi.79.16.10356-10368.2005 |
0.74 |
|
2005 |
Cherepanov P, Sun ZY, Rahman S, Maertens G, Wagner G, Engelman A. Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75. Nature Structural & Molecular Biology. 12: 526-32. PMID 15895093 DOI: 10.1038/Nsmb937 |
0.487 |
|
2005 |
Lu R, Limón A, Ghory HZ, Engelman A. Genetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase. Journal of Virology. 79: 2493-505. PMID 15681450 DOI: 10.1128/Jvi.79.4.2493-2505.2005 |
0.786 |
|
2005 |
Engelman A. The ups and downs of gene expression and retroviral DNA integration. Proceedings of the National Academy of Sciences of the United States of America. 102: 1275-6. PMID 15677323 DOI: 10.1073/Pnas.0409587101 |
0.418 |
|
2005 |
Devroe E, Silver PA, Engelman A. HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases. Virology. 331: 181-9. PMID 15582665 DOI: 10.1016/J.Virol.2004.10.023 |
0.558 |
|
2004 |
Byers KB, Engelman A, Fontes B. General guidelines for experimenting with HIV. Current Protocols in Immunology. Unit 12.1. PMID 18432923 DOI: 10.1002/0471142735.Im1201S59 |
0.538 |
|
2004 |
Lu R, Limón A, Devroe E, Silver PA, Cherepanov P, Engelman A. Class II integrase mutants with changes in putative nuclear localization signals are primarily blocked at a postnuclear entry step of human immunodeficiency virus type 1 replication. Journal of Virology. 78: 12735-46. PMID 15542626 DOI: 10.1128/Jvi.78.23.12735-12746.2004 |
0.743 |
|
2004 |
Cherepanov P, Devroe E, Silver PA, Engelman A. Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase. The Journal of Biological Chemistry. 279: 48883-92. PMID 15371438 DOI: 10.1074/Jbc.M406307200 |
0.509 |
|
2004 |
Turlure F, Devroe E, Silver PA, Engelman A. Human cell proteins and human immunodeficiency virus DNA integration. Frontiers in Bioscience : a Journal and Virtual Library. 9: 3187-208. PMID 15353349 DOI: 10.2741/1472 |
0.591 |
|
2004 |
Maertens G, Cherepanov P, Debyser Z, Engelborghs Y, Engelman A. Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75. The Journal of Biological Chemistry. 279: 33421-9. PMID 15163664 DOI: 10.1074/Jbc.M404700200 |
0.493 |
|
2004 |
Lu R, Nakajima N, Hofmann W, Benkirane M, Jeang KT, Sodroski J, Engelman A, Teh-Jeang K. Simian virus 40-based replication of catalytically inactive human immunodeficiency virus type 1 integrase mutants in nonpermissive T cells and monocyte-derived macrophages. Journal of Virology. 78: 658-68. PMID 14694097 DOI: 10.1128/Jvi.78.2.658-668.2004 |
0.744 |
|
2004 |
Lu R, Nakajima N, Hofmann W, Benkirane M, Jeang K, Sodroski J, Engelman A. Simian Virus 40-Based Replication of Catalytically Inactive Human Immunodeficiency Virus Type 1 Integrase Mutants in Nonpermissive T Cells and Monocyte-Derived Macrophages Journal of Virology. 78: 2654-2654. DOI: 10.1128/jvi.78.5.2654.2004 |
0.303 |
|
2003 |
Devroe E, Engelman A, Silver PA. Intracellular transport of human immunodeficiency virus type 1 integrase. Journal of Cell Science. 116: 4401-8. PMID 13130095 DOI: 10.1242/Jcs.00747 |
0.439 |
|
2003 |
Engelman A. The roles of cellular factors in retroviral integration Current Topics in Microbiology and Immunology. 281: 209-238. PMID 12932079 DOI: 10.1007/978-3-642-19012-4_6 |
0.452 |
|
2003 |
Lin CW, Engelman A. The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes. Journal of Virology. 77: 5030-6. PMID 12663813 DOI: 10.1128/Jvi.77.8.5030-5036.2003 |
0.548 |
|
2002 |
Limón A, Nakajima N, Lu R, Ghory HZ, Engelman A. Wild-type levels of nuclear localization and human immunodeficiency virus type 1 replication in the absence of the central DNA flap. Journal of Virology. 76: 12078-86. PMID 12414949 DOI: 10.1128/Jvi.76.23.12078-12086.2002 |
0.754 |
|
2002 |
Limón A, Devroe E, Lu R, Ghory HZ, Silver PA, Engelman A. Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import. Journal of Virology. 76: 10598-607. PMID 12368302 DOI: 10.1128/Jvi.76.21.10598-10607.2002 |
0.769 |
|
2001 |
Chen H, Engelman A. Asymmetric processing of human immunodeficiency virus type 1 cDNA in vivo: Implications for functional end coupling during the chemical steps of DNA transposition Molecular and Cellular Biology. 21: 6758-6767. PMID 11564861 DOI: 10.1128/Mcb.21.20.6758-6767.2001 |
0.373 |
|
2001 |
Nakajima N, Lu R, Engelman A. Human immunodeficiency virus type 1 replication in the absence of integrase-mediated DNA recombination: Definition of permissive and nonpermissive T-cell lines Journal of Virology. 75: 7944-7955. PMID 11483739 DOI: 10.1128/Jvi.75.17.7944-7955.2001 |
0.737 |
|
2000 |
Harris D, Engelman A. Both the structure and DNA binding function of the barrier-to-autointegration factor contribute to reconstitution of HIV type 1 integration in vitro Journal of Biological Chemistry. 275: 39671-39677. PMID 11005805 DOI: 10.1074/Jbc.M002626200 |
0.561 |
|
2000 |
Chen H, Engelman A. Characterization of a replication-defective human immunodeficiency virus type 1 att site mutant that is blocked after the 3' processing step of retroviral integration Journal of Virology. 74: 8188-8193. PMID 10933731 DOI: 10.1128/Jvi.74.17.8188-8193.2000 |
0.483 |
|
1999 |
Brown HE, Chen H, Engelman A. Structure-based mutagenesis of the human immunodeficiency virus type 1 DNA attachment site: effects on integration and cDNA synthesis. Journal of Virology. 73: 9011-20. PMID 10516007 DOI: 10.1128/Jvi.73.11.9011-9020.1999 |
0.566 |
|
1999 |
Engelman A. In vivo analysis of retroviral integrase structure and function Advances in Virus Research. 52: 411-426. PMID 10384245 DOI: 10.1016/S0065-3527(08)60309-7 |
0.431 |
|
1999 |
Chen H, Wei SQ, Engelman A. Multiple integrase functions are required to form the native structure of the human immunodeficiency virus type I intasome Journal of Biological Chemistry. 274: 17358-17364. PMID 10358097 DOI: 10.1074/Jbc.274.24.17358 |
0.598 |
|
1998 |
Chen H, Engelman A. The barrier-to-autointegration protein is a host factor for HIV type 1 integration Proceedings of the National Academy of Sciences of the United States of America. 95: 15270-15274. PMID 9860958 DOI: 10.1073/Pnas.95.26.15270 |
0.611 |
|
1997 |
Jenkins TM, Esposito D, Engelman A, Craigie R. Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking. The Embo Journal. 16: 6849-59. PMID 9362498 DOI: 10.1093/Emboj/16.22.6849 |
0.497 |
|
1997 |
Du Z, Ilyinskii PO, Lally K, Desrosiers RC, Engelman A. A mutation in integrase can compensate for mutations in the simian immunodeficiency virus att site Journal of Virology. 71: 8124-8132. PMID 9343162 DOI: 10.1128/Jvi.71.11.8124-8132.1997 |
0.41 |
|
1997 |
Engelman A, Liu Y, Chen H, Farzan M, Dyda F. Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase Journal of Virology. 71: 3507-3514. PMID 9094622 DOI: 10.1128/Jvi.71.5.3507-3514.1997 |
0.601 |
|
1996 |
Taddeo B, Carlini F, Verani P, Engelman A. Reversion of a human immunodeficiency virus type 1 integrase mutant at a second site restores enzyme function and virus infectivity Journal of Virology. 70: 8277-8284. PMID 8970947 DOI: 10.1128/Jvi.70.12.8277-8284.1996 |
0.449 |
|
1996 |
Engelman A. Biochemical characterization of recombinant equine infectious anemia virus integrase Protein Expression and Purification. 8: 299-304. PMID 8936591 DOI: 10.1006/Prep.1996.0104 |
0.453 |
|
1996 |
Jenkins TM, Engelman A, Ghirlando R, Craigie R. A Soluble Active Mutant of HIV-1 Integrase INVOLVEMENT OF BOTH THE CORE AND CARBOXYL-TERMINAL DOMAINS IN MULTIMERIZATION Journal of Biological Chemistry. 271: 7712-7718. PMID 8631811 DOI: 10.1074/Jbc.271.13.7712 |
0.593 |
|
1996 |
Dyda F, Hickman AB, Jenkins TM, Engelman A, Craigie R, Davies DR. The crystal structure of the catalytic core domain of HIV-1 integrase in a new crystal form Acta Crystallographica Section a Foundations of Crystallography. 52: C155-C155. DOI: 10.1107/S0108767396093038 |
0.41 |
|
1995 |
Englund G, Theodore TS, Freed EO, Engelman A, Martin MA. Integration is required for productive infection of monocyte-derived macrophages by human immunodeficiency virus type 1 Journal of Virology. 69: 3216-3219. PMID 7707554 DOI: 10.1128/Jvi.69.5.3216-3219.1995 |
0.601 |
|
1995 |
Engelman A, Craigie R. Efficient magnesium-dependent human immunodeficiency virus type 1 integrase activity Journal of Virology. 69: 5908-5911. PMID 7637039 DOI: 10.1128/Jvi.69.9.5908-5911.1995 |
0.527 |
|
1995 |
Lodi PJ, Ernst JA, Kuszewski J, Hickman AB, Engelman A, Craigie R, Clore GM, Gronenborn AM. Solution structure of the DNA binding domain of HIV-1 integrase. Biochemistry. 34: 9826-33. PMID 7632683 DOI: 10.1021/Bi00031A002 |
0.392 |
|
1995 |
Engelman A, Englund G, Orenstein JM, Martin MA, Craigie R. Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication Journal of Virology. 69: 2729-2736. PMID 7535863 DOI: 10.1128/Jvi.69.5.2729-2736.1995 |
0.598 |
|
1994 |
Mazumder A, Engelman A, Craigie R, Fesen M, Pommier Y. Intermolecular disintegration and intramolecular strand transfer activities of wild-type and mutant HIV-1 integrase Nucleic Acids Research. 22: 1037-1043. PMID 8152908 DOI: 10.1093/Nar/22.6.1037 |
0.46 |
|
1994 |
Engelman A, Hickman AB, Craigie R. The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding Journal of Virology. 68: 5911-5917. PMID 8057470 DOI: 10.1128/Jvi.68.9.5911-5917.1994 |
0.404 |
|
1994 |
Vicenzi E, Dimitrov DS, Engelman A, Migone TS, Purcell DF, Leonard J, Englund G, Martin MA. An integration-defective U5 deletion mutant of human immunodeficiency virus type 1 reverts by eliminating additional long terminal repeat sequences. Journal of Virology. 68: 7879-90. PMID 7966578 DOI: 10.1128/Jvi.68.12.7879-7890.1994 |
0.622 |
|
1994 |
Engelman A. Most of the avian genome appears available for retroviral DNA integration Bioessays. 16: 797-799. PMID 7840756 DOI: 10.1002/Bies.950161105 |
0.394 |
|
1994 |
Dyda F, Hickman AB, Jenkins TM, Engelman A, Craigie R, Davies DR. Crystal structure of the catalytic domain of HIV-1 integrase: Similarity to other polynucleotidyl transferases Science. 266: 1981-1986. PMID 7801124 DOI: 10.1126/Science.7801124 |
0.523 |
|
1993 |
Bushman FD, Engelman A, Palmer I, Wingfield P, Craigie R. Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding Proceedings of the National Academy of Sciences of the United States of America. 90: 3428-3432. PMID 8386373 DOI: 10.1073/Pnas.90.8.3428 |
0.402 |
|
1993 |
Engelman A, Bushman F, Craigie R. Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex. The Embo Journal. 12: 3269-3275. DOI: 10.1002/J.1460-2075.1993.Tb05996.X |
0.547 |
|
1992 |
Engelman A, Craigie R. Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro Journal of Virology. 66: 6361-6369. PMID 1404595 DOI: 10.1128/Jvi.66.11.6361-6369.1992 |
0.391 |
|
1991 |
Craigie R, Mizuuchi K, Bushman FD, Engelman A. A rapid in vitro assay for HIV DNA integration. Nucleic Acids Research. 19: 2729-34. PMID 2041748 DOI: 10.1093/Nar/19.10.2729 |
0.565 |
|
1991 |
Engelman A, Mizuuchi K, Craigie R. HIV-1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer. Cell. 67: 1211-21. PMID 1760846 DOI: 10.1016/0092-8674(91)90297-C |
0.429 |
|
1990 |
Engelman A, Rosenberg N. bcr/abl and src but not myc and ras replace v-abl in lymphoid transformation Molecular and Cellular Biology. 10: 4365-4369. PMID 2164639 DOI: 10.1128/Mcb.10.8.4365 |
0.512 |
|
1990 |
Engelman A, Rosenberg N. Temperature-sensitive mutants of Abelson murine leukemia virus deficient in protein tyrosine kinase activity Journal of Virology. 64: 4242-4251. PMID 1696637 DOI: 10.1128/Jvi.64.9.4242-4251.1990 |
0.57 |
|
1988 |
Engelman A, Rosenberg N. The Abelson protein is required for initiation and maintenance for transformation in murine pre-B cells Current Topics in Microbiology and Immunology. 141: 310-315. PMID 3265094 DOI: 10.1007/978-3-642-74006-0_41 |
0.574 |
|
1987 |
Engelman A, Rosenberg N. Isolation of temperature-sensitive Abelson virus mutants by site-directed mutagenesis Proceedings of the National Academy of Sciences of the United States of America. 84: 8021-8025. PMID 2825174 DOI: 10.1073/Pnas.84.22.8021 |
0.58 |
|
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