| Year |
Citation |
Score |
| 2024 |
Biswas A, Choudhuri I, Arnold E, Lyumkis D, Haldane A, Levy RM. Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure. Proceedings of the National Academy of Sciences of the United States of America. 121: e2316662121. PMID 38557187 DOI: 10.1073/pnas.2316662121 |
0.314 |
|
| 2023 |
Jiang X, Huang B, Rumrill S, Pople D, Zalloum WA, Kang D, Zhao F, Ji X, Gao Z, Hu L, Wang Z, Xie M, De Clercq E, Ruiz FX, Arnold E, et al. Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors. Communications Chemistry. 6: 83. PMID 37120482 DOI: 10.1038/s42004-023-00888-4 |
0.346 |
|
| 2023 |
Mansouri M, Rumrill S, Dawson S, Johnson A, Pinson JA, Gunzburg MJ, Latham CF, Barlow N, Mbogo GW, Ellenberg P, Headey SJ, Sluis-Cremer N, Tyssen D, Bauman JD, Ruiz FX, ... Arnold E, et al. Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach. Molecules (Basel, Switzerland). 28. PMID 37049868 DOI: 10.3390/molecules28073103 |
0.385 |
|
| 2022 |
Singh AK, De Wijngaert B, Bijnens M, Uyttersprot K, Nguyen H, Martinez SE, Schols D, Herdewijn P, Pannecouque C, Arnold E, Das K. Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine. Proceedings of the National Academy of Sciences of the United States of America. 119: e2203660119. PMID 35858448 DOI: 10.1073/pnas.2203660119 |
0.322 |
|
| 2022 |
Harrison JJEK, Passos DO, Bruhn JF, Bauman JD, Tuberty L, DeStefano JJ, Ruiz FX, Lyumkis D, Arnold E. Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation. Science Advances. 8: eabn9874. PMID 35857464 DOI: 10.1126/sciadv.abn9874 |
0.347 |
|
| 2022 |
Ruiz FX, Hoang A, Dilmore CR, DeStefano JJ, Arnold E. Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposing. Drug Discovery Today. PMID 35218925 DOI: 10.1016/j.drudis.2022.02.016 |
0.333 |
|
| 2021 |
Losada N, Ruiz FX, Curreli F, Gruber K, Pilch A, Altieri A, Kurkin AV, Das K, Debnath AK, Arnold E. Correction to "HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites". Journal of Medicinal Chemistry. PMID 34915707 DOI: 10.1021/acs.jmedchem.1c02061 |
0.318 |
|
| 2021 |
Losada N, Ruiz FX, Curreli F, Gruber K, Pilch A, Das K, Debnath AK, Arnold E. HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites. Journal of Medicinal Chemistry. 64: 16530-16540. PMID 34735153 DOI: 10.1021/acs.jmedchem.1c01104 |
0.393 |
|
| 2021 |
Kang D, Ruiz FX, Sun Y, Feng D, Jing L, Wang Z, Zhang T, Gao S, Sun L, De Clercq E, Pannecouque C, Arnold E, Zhan P, Liu X. 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies. Journal of Medicinal Chemistry. PMID 33734714 DOI: 10.1021/acs.jmedchem.1c00268 |
0.391 |
|
| 2020 |
Himmel DM, Arnold E. Non-Nucleoside Reverse Transcriptase Inhibitors Join Forces with Integrase Inhibitors to Combat HIV. Pharmaceuticals (Basel, Switzerland). 13. PMID 32545407 DOI: 10.3390/Ph13060122 |
0.403 |
|
| 2020 |
Nguyen PDM, Zheng J, Gremminger TJ, Qiu L, Zhang D, Tuske S, Lange MJ, Griffin PR, Arnold E, Chen SJ, Zou X, Heng X, Burke DH. Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase. Nucleic Acids Research. PMID 31943114 DOI: 10.1093/Nar/Gkz1224 |
0.444 |
|
| 2020 |
Xavier Ruiz F, Arnold E. Evolving understanding of HIV-1 reverse transcriptase structure, function, inhibition, and resistance. Current Opinion in Structural Biology. 61: 113-123. PMID 31935541 DOI: 10.1016/J.Sbi.2019.11.011 |
0.482 |
|
| 2020 |
Kang D, Ruiz FX, Feng D, Pilch A, Zhao T, Wei F, Wang Z, Sun Y, Fang Z, De Clercq E, Pannecouque C, Arnold E, Zhan P, Liu X. Discovery and Characterization of Fluorine-Substituted Diarylpyrimidines Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. Journal of Medicinal Chemistry. PMID 31935327 DOI: 10.1021/Acs.Jmedchem.9B01769 |
0.399 |
|
| 2019 |
Ruiz FX, Hoang A, Das K, Arnold E. Structural Basis of HIV-1 Inhibition by the Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY-1. Journal of Medicinal Chemistry. PMID 31603676 DOI: 10.1021/Acs.Jmedchem.9B01289 |
0.491 |
|
| 2019 |
Biswas A, Haldane A, Arnold E, Levy RM. Epistasis and entrenchment of drug resistance in HIV-1 subtype B. Elife. 8. PMID 31591964 DOI: 10.7554/Elife.50524 |
0.41 |
|
| 2019 |
LaVoie EJ, Sagong HY, Bauman JD, Nogales A, Martínez-Sobrido L, Arnold E. Aryl and arylalkyl substituted 3-hydroxypyridin(1H)-2-ones: Synthesis and evaluation as inhibitors of influenza A endonuclease. Chemmedchem. PMID 30983160 DOI: 10.1002/Cmdc.201900084 |
0.33 |
|
| 2019 |
Das K, Martinez SE, DeStefano JJ, Arnold E. Structure of HIV-1 RT/dsRNA initiation complex prior to nucleotide incorporation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30902895 DOI: 10.2210/Pdb6Hak/Pdb |
0.441 |
|
| 2019 |
Biswas A, Haldane A, Arnold E, Levy RM. Author response: Epistasis and entrenchment of drug resistance in HIV-1 subtype B Elife. DOI: 10.7554/Elife.50524.030 |
0.406 |
|
| 2018 |
Martinez SE, Bauman JD, Das K, Arnold E. Structure of HIV-1 reverse transcriptase/d4TTP complex: novel DNA cross-linking site and pH-dependent conformational changes. Protein Science : a Publication of the Protein Society. PMID 30499174 DOI: 10.1002/Pro.3559 |
0.421 |
|
| 2018 |
Boyer PL, Smith SJ, Zhao XZ, Das K, Gruber K, Arnold E, Burke TR, Hughes SH. Developing and evaluating inhibitors against the RNase H active site of HIV-1 RT. Journal of Virology. PMID 29643235 DOI: 10.1128/Jvi.02203-17 |
0.456 |
|
| 2018 |
Vedithi SC, Malhotra S, Das M, Daniel S, Kishore N, George A, Arumugam S, Rajan L, Ebenezer M, Ascher DB, Arnold E, Blundell TL. Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae. Scientific Reports. 8: 5016. PMID 29567948 DOI: 10.1038/S41598-018-23423-1 |
0.329 |
|
| 2017 |
Das K, Martinez SE, Arnold E. Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex that Confer Multi-Nucleoside Drug Resistance. Antimicrobial Agents and Chemotherapy. PMID 28396546 DOI: 10.1128/Aac.00224-17 |
0.443 |
|
| 2017 |
Lin W, Mandal S, Degen D, Liu Y, Ebright YW, Li S, Feng Y, Zhang Y, Mandal S, Jiang Y, Liu S, Gigliotti M, Talaue M, Connell N, Das K, ... Arnold E, et al. Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. Molecular Cell. PMID 28392175 DOI: 10.1016/J.Molcel.2017.03.001 |
0.356 |
|
| 2017 |
Balzarini J, Menni M, Das K, van Berckelaer L, Ford A, Maguire NM, Liekens S, Boehmer PE, Arnold E, Götte M, Maguire AR. Guanine α-carboxy nucleoside phosphonate (G-α-CNP) shows a different inhibitory kinetic profile against the DNA polymerases of human immunodeficiency virus (HIV) and herpes viruses. Biochemical Pharmacology. PMID 28390939 DOI: 10.1016/J.Bcp.2017.04.001 |
0.392 |
|
| 2017 |
Chesterman C, Tuske S, Zheng J, Jeon Y, Zhang C, Cantara W, Musier-Forsyth K, Griffin PR, Lyumkis D, Arnold E. Structural investigation of the HIV-1 reverse transcriptase initiation complex by HDX, SAXS, CryoEM and X-ray crystallography Acta Crystallographica Section a Foundations and Advances. 73: a286-a286. DOI: 10.1107/S0108767317097185 |
0.402 |
|
| 2016 |
Das K, Balzarini J, Miller MT, Maguire AR, DeStefano JJ, Arnold E. Correction to Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet. Acs Chemical Biology. PMID 27696816 DOI: 10.1021/Acschembio.6B00798 |
0.418 |
|
| 2016 |
Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. The Journal of Biological Chemistry. 291: 23569-23577. PMID 27645997 DOI: 10.1074/Jbc.M116.753384 |
0.467 |
|
| 2016 |
Das K, Balzarini J, Miller MT, Maguire AR, DeStefano JJ, Arnold E. Conformational states of HIV-1 reverse transcriptase for nucleotide incorporation vs. pyrophosphorolysis - binding of foscarnet. Acs Chemical Biology. PMID 27192549 DOI: 10.1021/Acschembio.6B00187 |
0.414 |
|
| 2016 |
Bauman JD, Harrison JJ, Arnold E. Rapid experimental SAD phasing and hot-spot identification with halogenated fragments. Iucrj. 3: 51-60. PMID 26870381 DOI: 10.1107/S2052252515021259 |
0.402 |
|
| 2015 |
Neogi U, Häggblom A, Singh K, Rogers LC, Rao SD, Amogne W, Schülter E, Zazzi M, Arnold E, Sarafianos SG, Sönnerborg A. Factors influencing the efficacy of rilpivirine in HIV-1 subtype C in low- and middle-income countries. The Journal of Antimicrobial Chemotherapy. PMID 26518047 DOI: 10.1093/Jac/Dkv359 |
0.314 |
|
| 2015 |
Boyer PL, Das K, Arnold E, Hughes SH. Analysis of the AZT-Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase. Antimicrobial Agents and Chemotherapy. PMID 26324274 DOI: 10.1128/Aac.05069-14 |
0.439 |
|
| 2015 |
Miller MT, Tuske S, Das K, DeStefano JJ, Arnold E. Structure of HIV-1 reverse transcriptase bound to a novel 38-mer hairpin template-primer DNA aptamer. Protein Science : a Publication of the Protein Society. PMID 26296781 DOI: 10.1002/Pro.2776 |
0.465 |
|
| 2014 |
Singh K, Flores JA, Kirby KA, Neogi U, Sonnerborg A, Hachiya A, Das K, Arnold E, McArthur C, Parniak M, Sarafianos SG. Drug resistance in non-B subtype HIV-1: impact of HIV-1 reverse transcriptase inhibitors. Viruses. 6: 3535-62. PMID 25254383 DOI: 10.3390/V6093535 |
0.422 |
|
| 2014 |
Patel D, Bauman JD, Arnold E. Advantages of crystallographic fragment screening: functional and mechanistic insights from a powerful platform for efficient drug discovery. Progress in Biophysics and Molecular Biology. 116: 92-100. PMID 25117499 DOI: 10.1016/J.Pbiomolbio.2014.08.004 |
0.307 |
|
| 2014 |
Das K, Martinez SE, Bandwar RP, Arnold E. Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage. Nucleic Acids Research. 42: 8125-37. PMID 24880687 DOI: 10.1093/Nar/Gku487 |
0.313 |
|
| 2014 |
Degen D, Feng Y, Zhang Y, Ebright KY, Ebright YW, Gigliotti M, Vahedian-Movahed H, Mandal S, Talaue M, Connell N, Arnold E, Fenical W, Ebright RH. Transcription inhibition by the depsipeptide antibiotic salinamide A. Elife. 3: e02451. PMID 24843001 DOI: 10.7554/Elife.02451 |
0.359 |
|
| 2014 |
Himmel DM, Myshakina NS, Ilina T, Van Ry A, Ho WC, Parniak MA, Arnold E. Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNase H domain of HIV-1 reverse transcriptase and structure-activity analysis of inhibitor analogs. Journal of Molecular Biology. 426: 2617-31. PMID 24840303 DOI: 10.1016/J.Jmb.2014.05.006 |
0.478 |
|
| 2014 |
Abram ME, Ferris AL, Das K, Quinoñes O, Shao W, Tuske S, Alvord WG, Arnold E, Hughes SH. Mutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication. Journal of Virology. 88: 7589-601. PMID 24760888 DOI: 10.1128/Jvi.00302-14 |
0.381 |
|
| 2014 |
Zhang Y, Degen D, Ho MX, Sineva E, Ebright KY, Ebright YW, Mekler V, Vahedian-Movahed H, Feng Y, Yin R, Tuske S, Irschik H, Jansen R, Maffioli S, Donadio S, ... Arnold E, et al. GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides. Elife. 3: e02450. PMID 24755292 DOI: 10.7554/Elife.02450 |
0.324 |
|
| 2014 |
Vijayan RS, Arnold E, Das K. Molecular dynamics study of HIV-1 RT-DNA-nevirapine complexes explains NNRTI inhibition and resistance by connection mutations. Proteins. 82: 815-29. PMID 24174331 DOI: 10.1002/Prot.24460 |
0.416 |
|
| 2014 |
Arnold E. Triumphs of Crystallography in Tackling HIV/AIDS: Drugs by Design Acta Crystallographica Section a Foundations and Advances. 70: C7-C7. DOI: 10.1107/S2053273314099926 |
0.499 |
|
| 2013 |
Das K, Sarafianos SG, Arnold E. Structural requirements for RNA degradation by HIV-1 reverse transcriptase. Nature Structural & Molecular Biology. 20: 1341-2. PMID 24304910 DOI: 10.1038/Nsmb.2725 |
0.415 |
|
| 2013 |
Yi G, Lapelosa M, Bradley R, Mariano TM, Dietz DE, Hughes S, Wrin T, Petropoulos C, Gallicchio E, Levy RM, Arnold E, Arnold GF. Correction: Chimeric Rhinoviruses Displaying MPER Epitopes Elicit Anti-HIV Neutralizing Responses. Plos One. 8. PMID 24116242 DOI: 10.1371/Annotation/57Fc0148-19Fe-4B8B-B2F4-Bb5F60Baa971 |
0.352 |
|
| 2013 |
Parhi AK, Xiang A, Bauman JD, Patel D, Vijayan RSK, Das K, Arnold E, Lavoie EJ. Phenyl substituted 3-hydroxypyridin-2(1H)-ones: Inhibitors of influenza A endonuclease Bioorganic and Medicinal Chemistry. 21: 6435-6446. PMID 24055080 DOI: 10.1016/J.Bmc.2013.08.053 |
0.342 |
|
| 2013 |
Yi G, Lapelosa M, Bradley R, Mariano TM, Dietz DE, Hughes S, Wrin T, Petropoulos C, Gallicchio E, Levy RM, Arnold E, Arnold GF. Chimeric rhinoviruses displaying MPER epitopes elicit anti-HIV neutralizing responses. Plos One. 8: e72205. PMID 24039745 DOI: 10.1371/Journal.Pone.0072205 |
0.391 |
|
| 2013 |
Bauman JD, Patel D, Baker SF, Vijayan RS, Xiang A, Parhi AK, Martínez-Sobrido L, LaVoie EJ, Das K, Arnold E. Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors. Acs Chemical Biology. 8: 2501-8. PMID 23978130 DOI: 10.1021/Cb400400J |
0.353 |
|
| 2013 |
Bollini M, Frey KM, Cisneros JA, Spasov KA, Das K, Bauman JD, Arnold E, Anderson KS, Jorgensen WL. Extension into the entrance channel of HIV-1 reverse transcriptase--crystallography and enhanced solubility. Bioorganic & Medicinal Chemistry Letters. 23: 5209-12. PMID 23899617 DOI: 10.1016/J.Bmcl.2013.06.093 |
0.406 |
|
| 2013 |
Das K, Arnold E. HIV-1 reverse transcriptase and antiviral drug resistance. Part 1. Current Opinion in Virology. 3: 111-8. PMID 23602471 DOI: 10.1016/J.Coviro.2013.03.012 |
0.469 |
|
| 2013 |
Das K, Arnold E. HIV-1 reverse transcriptase and antiviral drug resistance. Part 2. Current Opinion in Virology. 3: 119-28. PMID 23602470 DOI: 10.1016/j.coviro.2013.03.014 |
0.326 |
|
| 2013 |
Kuroda DG, Bauman JD, Challa JR, Patel D, Troxler T, Das K, Arnold E, Hochstrasser RM. Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase. Nature Chemistry. 5: 174-81. PMID 23422558 DOI: 10.1038/Nchem.1559 |
0.451 |
|
| 2013 |
Bauman JD, Patel D, Dharia C, Fromer MW, Ahmed S, Frenkel Y, Vijayan RS, Eck JT, Ho WC, Das K, Shatkin AJ, Arnold E. Detecting allosteric sites of HIV-1 reverse transcriptase by X-ray crystallographic fragment screening. Journal of Medicinal Chemistry. 56: 2738-46. PMID 23342998 DOI: 10.1021/Jm301271J |
0.668 |
|
| 2012 |
Johnson BC, Pauly GT, Rai G, Patel D, Bauman JD, Baker HL, Das K, Schneider JP, Maloney DJ, Arnold E, Thomas CJ, Hughes SH. A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants. Retrovirology. 9: 99. PMID 23217210 DOI: 10.1186/1742-4690-9-99 |
0.362 |
|
| 2012 |
Zhang Y, Feng Y, Chatterjee S, Tuske S, Ho MX, Arnold E, Ebright RH. Structural basis of transcription initiation. Science (New York, N.Y.). 338: 1076-80. PMID 23086998 DOI: 10.1126/Science.1227786 |
0.31 |
|
| 2012 |
Das K, Martinez SE, Bauman JD, Arnold E. HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nature Structural & Molecular Biology. 19: 253-9. PMID 22266819 DOI: 10.1038/nsmb.2223 |
0.321 |
|
| 2012 |
Bauman JD, Patel D, Arnold E. Fragment screening and HIV therapeutics. Topics in Current Chemistry. 317: 181-200. PMID 21972022 DOI: 10.1007/128_2011_232 |
0.412 |
|
| 2011 |
Felts AK, Labarge K, Bauman JD, Patel DV, Himmel DM, Arnold E, Parniak MA, Levy RM. Identification of alternative binding sites for inhibitors of HIV-1 ribonuclease H through comparative analysis of virtual enrichment studies. Journal of Chemical Information and Modeling. 51: 1986-98. PMID 21714567 DOI: 10.1021/Ci200194W |
0.377 |
|
| 2011 |
Chu C, Das K, Tyminski JR, Bauman JD, Guan R, Qiu W, Montelione GT, Arnold E, Shatkin AJ. Structure of the guanylyltransferase domain of human mRNA capping enzyme. Proceedings of the National Academy of Sciences of the United States of America. 108: 10104-8. PMID 21636784 DOI: 10.1073/Pnas.1106610108 |
0.33 |
|
| 2011 |
Chung S, Himmel DM, Jiang JK, Wojtak K, Bauman JD, Rausch JW, Wilson JA, Beutler JA, Thomas CJ, Arnold E, Le Grice SF. Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H. Journal of Medicinal Chemistry. 54: 4462-73. PMID 21568335 DOI: 10.1021/Jm2000757 |
0.398 |
|
| 2011 |
Das K, Bauman JD, Rim AS, Dharia C, Clark AD, Camarasa MJ, Balzarini J, Arnold E. Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket. Journal of Medicinal Chemistry. 54: 2727-37. PMID 21446702 DOI: 10.1021/Jm101536X |
0.461 |
|
| 2010 |
Tu X, Das K, Han Q, Bauman JD, Clark AD, Hou X, Frenkel YV, Gaffney BL, Jones RA, Boyer PL, Hughes SH, Sarafianos SG, Arnold E. Structural basis of HIV-1 resistance to AZT by excision. Nature Structural & Molecular Biology. 17: 1202-9. PMID 20852643 DOI: 10.1038/Nsmb.1908 |
0.685 |
|
| 2010 |
Lapelosa M, Arnold GF, Gallicchio E, Arnold E, Levy RM. Antigenic characteristics of rhinovirus chimeras designed in silico for enhanced presentation of HIV-1 gp41 epitopes [corrected]. Journal of Molecular Biology. 397: 752-66. PMID 20138057 DOI: 10.1016/J.Jmb.2010.01.064 |
0.416 |
|
| 2010 |
Cullen MD, Ho WC, Bauman JD, Das K, Arnold E, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, Clercq ED, Cushman M. Crystal Structure of HIV-1 reverse transcriptase (RT) in complex with the alkenyldiarylmethane (ADAM) Non-nucleoside RT Inhibitor (E)-S-Methyl 5-(1-(3,7-Dimethyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)-5-(5-methyl-1,3,4-oxadiazol-2-yl)pent-1-enyl)-2-methoxy-3-methylbenzothioate. Journal of Medicinal Chemistry. 52: 6467-6473. DOI: 10.2210/Pdb3Irx/Pdb |
0.375 |
|
| 2009 |
Han Q, Sarafianos SG, Arnold E, Parniak MA, Gaffney BL, Jones RA. Synthesis of Boranoate, Selenoate, and Thioate Analogs of AZTp(4)A and Ap(4)A. Tetrahedron. 65: 7915-7920. PMID 20625456 DOI: 10.1016/J.Tet.2009.07.079 |
0.394 |
|
| 2009 |
Himmel DM, Maegley KA, Pauly TA, Bauman JD, Das K, Dharia C, Clark AD, Ryan K, Hickey MJ, Love RA, Hughes SH, Bergqvist S, Arnold E. Structure of HIV-1 reverse transcriptase with the inhibitor beta-Thujaplicinol bound at the RNase H active site. Structure (London, England : 1993). 17: 1625-35. PMID 20004166 DOI: 10.1016/J.Str.2009.09.016 |
0.365 |
|
| 2009 |
Ho MX, Hudson BP, Das K, Arnold E, Ebright RH. Structures of RNA polymerase-antibiotic complexes. Current Opinion in Structural Biology. 19: 715-23. PMID 19926275 DOI: 10.1016/J.Sbi.2009.10.010 |
0.34 |
|
| 2009 |
Hudson BP, Quispe J, Lara-González S, Kim Y, Berman HM, Arnold E, Ebright RH, Lawson CL. Three-dimensional EM structure of an intact activator-dependent transcription initiation complex Proceedings of the National Academy of Sciences of the United States of America. 106: 19830-19835. PMID 19903881 DOI: 10.1073/Pnas.0908782106 |
0.304 |
|
| 2009 |
Paris KA, Haq O, Felts AK, Das K, Arnold E, Levy RM. Conformational landscape of the human immunodeficiency virus type 1 reverse transcriptase non-nucleoside inhibitor binding pocket: lessons for inhibitor design from a cluster analysis of many crystal structures. Journal of Medicinal Chemistry. 52: 6413-20. PMID 19827836 DOI: 10.1021/Jm900854H |
0.375 |
|
| 2009 |
Das K, Bandwar RP, White KL, Feng JY, Sarafianos SG, Tuske S, Tu X, Clark AD, Boyer PL, Hou X, Gaffney BL, Jones RA, Miller MD, Hughes SH, Arnold E. Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance. The Journal of Biological Chemistry. 284: 35092-100. PMID 19812032 DOI: 10.1074/Jbc.M109.022525 |
0.441 |
|
| 2009 |
Cullen MD, Ho WC, Bauman JD, Das K, Arnold E, Hartman TL, Watson KM, Buckheit RW, Pannecouque C, De Clercq E, Cushman M. Crystallographic study of a novel subnanomolar inhibitor provides insight on the binding interactions of alkenyldiarylmethanes with human immunodeficiency virus-1 reverse transcriptase. Journal of Medicinal Chemistry. 52: 6467-73. PMID 19775161 DOI: 10.1021/Jm901167T |
0.413 |
|
| 2009 |
Frenkel YV, Gallicchio E, Das K, Levy RM, Arnold E. Molecular dynamics study of non-nucleoside reverse transcriptase inhibitor 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (TMC278/rilpivirine) aggregates: correlation between amphiphilic properties of the drug and oral bioavailability. Journal of Medicinal Chemistry. 52: 5896-905. PMID 19739675 DOI: 10.1021/Jm900282Z |
0.619 |
|
| 2009 |
Arnold GF, Velasco PK, Holmes AK, Wrin T, Geisler SC, Phung P, Tian Y, Resnick DA, Ma X, Mariano TM, Petropoulos CJ, Taylor JW, Katinger H, Arnold E. Broad neutralization of human immunodeficiency virus type 1 (HIV-1) elicited from human rhinoviruses that display the HIV-1 gp41 ELDKWA epitope. Journal of Virology. 83: 5087-100. PMID 19279101 DOI: 10.1128/Jvi.00184-09 |
0.411 |
|
| 2009 |
Lapelosa M, Gallicchio E, Arnold GF, Arnold E, Levy RM. In silico vaccine design based on molecular simulations of rhinovirus chimeras presenting HIV-1 gp41 epitopes. Journal of Molecular Biology. 385: 675-91. PMID 19026659 DOI: 10.1016/J.Jmb.2008.10.089 |
0.415 |
|
| 2009 |
Sarafianos SG, Marchand B, Das K, Himmel DM, Parniak MA, Hughes SH, Arnold E. Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition. Journal of Molecular Biology. 385: 693-713. PMID 19022262 DOI: 10.1016/J.Jmb.2008.10.071 |
0.356 |
|
| 2008 |
Sarafianos SG, Arnold E. Biochemistry. RT slides home... Science (New York, N.Y.). 322: 1059-60. PMID 19008434 DOI: 10.1126/Science.1167454 |
0.394 |
|
| 2008 |
Mukhopadhyay J, Das K, Ismail S, Koppstein D, Jang M, Hudson B, Sarafianos S, Tuske S, Patel J, Jansen R, Irschik H, Arnold E, Ebright RH. The RNA polymerase "switch region" is a target for inhibitors. Cell. 135: 295-307. PMID 18957204 DOI: 10.1016/J.Cell.2008.09.033 |
0.314 |
|
| 2008 |
Bauman JD, Das K, Ho WC, Baweja M, Himmel DM, Clark AD, Oren DA, Boyer PL, Hughes SH, Shatkin AJ, Arnold E. Crystal engineering of HIV-1 reverse transcriptase for structure-based drug design. Nucleic Acids Research. 36: 5083-92. PMID 18676450 DOI: 10.1093/Nar/Gkn464 |
0.447 |
|
| 2008 |
Kawamoto A, Kodama E, Sarafianos SG, Sakagami Y, Kohgo S, Kitano K, Ashida N, Iwai Y, Hayakawa H, Nakata H, Mitsuya H, Arnold E, Matsuoka M. 2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants. The International Journal of Biochemistry & Cell Biology. 40: 2410-20. PMID 18487070 DOI: 10.1016/j.biocel.2008.04.007 |
0.367 |
|
| 2008 |
Arnold E, Sarafianos SG. Molecular biology: an HIV secret uncovered. Nature. 453: 169-70. PMID 18464731 DOI: 10.1038/453169B |
0.385 |
|
| 2008 |
Knight JL, Zhou Z, Gallicchio E, Himmel DM, Friesner RA, Arnold E, Levy RM. Exploring structural variability in X-ray crystallographic models using protein local optimization by torsion-angle sampling. Acta Crystallographica. Section D, Biological Crystallography. 64: 383-96. PMID 18391405 DOI: 10.1107/S090744490800070X |
0.326 |
|
| 2008 |
Das K, Bauman JD, Clark AD, Frenkel YV, Lewi PJ, Shatkin AJ, Hughes SH, Arnold E. High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations. Proceedings of the National Academy of Sciences of the United States of America. 105: 1466-71. PMID 18230722 DOI: 10.1073/Pnas.0711209105 |
0.707 |
|
| 2008 |
Fang C, Bauman JD, Das K, Remorino A, Arnold E, Hochstrasser RM. Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase. Proceedings of the National Academy of Sciences of the United States of America. 105: 1472-7. PMID 18040050 DOI: 10.1073/Pnas.0709320104 |
0.396 |
|
| 2008 |
Das K, Baruman JD, Bandwar R, Jr ADC, Hughes SH, Arnold E. Role of structures in designing anti-AIDS drugs targeting reverse transcriptase Acta Crystallographica Section A. 64: 37-37. DOI: 10.1107/S0108767308098826 |
0.346 |
|
| 2008 |
Clark A, Bauman J, Das K, Dharia C, Boyer P, Clark P, Shatkin A, Hughes S, Arnold E. Many are called but few are chosen: 20 years of crystallizing HIV-1 reverse transcriptase Acta Crystallographica Section a Foundations of Crystallography. 64: C241-C241. DOI: 10.1107/S010876730809226X |
0.395 |
|
| 2008 |
Himmel D, Pauly T, Bauman J, Dharia C, Clark A, Ryan K, Maegley K, Arnold E. Structure for an HIV-1 reverse transcriptase RNase H inhibitor bound at the active site Acta Crystallographica Section a Foundations of Crystallography. 64: C348-C348. DOI: 10.1107/S0108767308088880 |
0.447 |
|
| 2007 |
Su Y, Gallicchio E, Das K, Arnold E, Levy RM. Linear Interaction Energy (LIE) Models for Ligand Binding in Implicit Solvent: Theory and Application to the Binding of NNRTIs to HIV-1 Reverse Transcriptase. Journal of Chemical Theory and Computation. 3: 256-77. PMID 26627170 DOI: 10.1021/Ct600258E |
0.305 |
|
| 2007 |
Han Q, Sarafianos SG, Arnold E, Parniak MA, Gaffney BL, Jones RA. Synthesis of AZTpSpCX2ppSA and AZTpSpCX2ppSAZT: hydrolysis-resistant potential inhibitors of the AZT excision reaction of HIV-1 RT. Organic Letters. 9: 5243-6. PMID 17988141 DOI: 10.1021/Ol7023746 |
0.389 |
|
| 2007 |
Morningstar ML, Roth T, Farnsworth DW, Smith MK, Watson K, Buckheit RW, Das K, Zhang W, Arnold E, Julias JG, Hughes SH, Michejda CJ. Synthesis, biological activity, and crystal structure of potent nonnucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme. Journal of Medicinal Chemistry. 50: 4003-15. PMID 17663538 DOI: 10.1021/Jm060103D |
0.44 |
|
| 2007 |
Dharmasena S, Pongracz Z, Arnold E, Sarafianos SG, Parniak MA. 3'-Azido-3'-deoxythymidine-(5')-tetraphospho-(5')-adenosine, the product of ATP-mediated excision of chain-terminating AZTMP, is a potent chain-terminating substrate for HIV-1 reverse transcriptase. Biochemistry. 46: 828-36. PMID 17223704 DOI: 10.1021/Bi061364S |
0.439 |
|
| 2007 |
Das K, Sarafianos SG, Clark AD, Boyer PL, Hughes SH, Arnold E. Crystal structures of clinically relevant Lys103Asn/Tyr181Cys double mutant HIV-1 reverse transcriptase in complexes with ATP and non-nucleoside inhibitor HBY 097. Journal of Molecular Biology. 365: 77-89. PMID 17056061 DOI: 10.1016/j.jmb.2006.08.097 |
0.354 |
|
| 2007 |
Tu X, Sarafianos SG, Han Q, Das K, Hou X, Bauman J, Clark AD, Gaffney BL, Jones RA, Boyer PL, Hughes SH, Arnold E. Structures of Wild-Type and AZT-Resistant HIV-1 Reverse Transcriptase Complexed with AZTppppA Yield Insights into the Nucleotide Excision Mechanism The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A640-A |
0.436 |
|
| 2007 |
Rashin AHL, Steege KE, Lee BJ, Das K, Bauman J, Frenkel YV, Arnold E, Castner EW. Spectroscopic Studies of Rilpivirine (TMC278/R278474) in Complex with HIV‐1 Reverse Transcriptase The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A630-C |
0.573 |
|
| 2006 |
Himmel DM, Sarafianos SG, Dharmasena S, Hossain MM, McCoy-Simandle K, Ilina T, Clark AD, Knight JL, Julias JG, Clark PK, Krogh-Jespersen K, Levy RM, Hughes SH, Parniak MA, Arnold E. HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site. Acs Chemical Biology. 1: 702-12. PMID 17184135 DOI: 10.1021/Cb600303Y |
0.52 |
|
| 2006 |
Boyer PL, Sarafianos SG, Clark PK, Arnold E, Hughes SH. Why do HIV-1 and HIV-2 use different pathways to develop AZT resistance? Plos Pathogens. 2: e10. PMID 16485036 DOI: 10.1371/journal.ppat.0020010 |
0.351 |
|
| 2006 |
Maeda K, Das D, Ogata-Aoki H, Nakata H, Miyakawa T, Tojo Y, Norman R, Takaoka Y, Ding J, Arnold GF, Arnold E, Mitsuya H. Structural and molecular interactions of CCR5 inhibitors with CCR5. The Journal of Biological Chemistry. 281: 12688-98. PMID 16476734 DOI: 10.1074/jbc.M512688200 |
0.36 |
|
| 2006 |
McWilliams MJ, Julias JG, Sarafianos SG, Alvord WG, Arnold E, Hughes SH. Combining mutations in HIV-1 reverse transcriptase with mutations in the HIV-1 polypurine tract affects RNase H cleavages involved in PPT utilization. Virology. 348: 378-88. PMID 16473384 DOI: 10.1016/J.Virol.2005.12.042 |
0.393 |
|
| 2006 |
Hamburgh ME, Curr KA, Monaghan M, Rao VR, Tripathi S, Preston BD, Sarafianos S, Arnold E, Darden T, Prasad VR. Structural determinants of slippage-mediated mutations by human immunodeficiency virus type 1 reverse transcriptase. The Journal of Biological Chemistry. 281: 7421-8. PMID 16423828 DOI: 10.1074/Jbc.M511380200 |
0.474 |
|
| 2005 |
Himmel DM, Das K, Clark AD, Hughes SH, Benjahad A, Oumouch S, Guillemont J, Coupa S, Poncelet A, Csoka I, Meyer C, Andries K, Nguyen CH, Grierson DS, Arnold E. Crystal structures for HIV-1 reverse transcriptase in complexes with three pyridinone derivatives: a new class of non-nucleoside inhibitors effective against a broad range of drug-resistant strains. Journal of Medicinal Chemistry. 48: 7582-91. PMID 16302798 DOI: 10.1021/Jm0500323 |
0.363 |
|
| 2005 |
Tuske S, Sarafianos SG, Wang X, Hudson B, Sineva E, Mukhopadhyay J, Birktoft JJ, Leroy O, Ismail S, Clark AD, Dharia C, Napoli A, Laptenko O, Lee J, Borukhov S, ... ... Arnold E, et al. Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation. Cell. 122: 541-52. PMID 16122422 DOI: 10.1016/J.Cell.2005.07.017 |
0.328 |
|
| 2005 |
Mulky A, Sarafianos SG, Jia Y, Arnold E, Kappes JC. Identification of amino acid residues in the human immunodeficiency virus type-1 reverse transcriptase tryptophan-repeat motif that are required for subunit interaction using infectious virions. Journal of Molecular Biology. 349: 673-84. PMID 15893326 DOI: 10.1016/J.Jmb.2005.03.057 |
0.358 |
|
| 2005 |
Guillemont J, Pasquier E, Palandjian P, Vernier D, Gaurrand S, Lewi PJ, Heeres J, de Jonge MR, Koymans LM, Daeyaert FF, Vinkers MH, Arnold E, Das K, Pauwels R, Andries K, et al. Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1. Journal of Medicinal Chemistry. 48: 2072-9. PMID 15771449 DOI: 10.1021/Jm040838N |
0.352 |
|
| 2005 |
Frenkel YV, Clark AD, Das K, Wang YH, Lewi PJ, Janssen PA, Arnold E. Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability. Journal of Medicinal Chemistry. 48: 1974-83. PMID 15771441 DOI: 10.1021/Jm049439I |
0.596 |
|
| 2005 |
Benjahad A, Croisy M, Monneret C, Bisagni E, Mabire D, Coupa S, Poncelet A, Csoka I, Guillemont J, Meyer C, Andries K, Pauwels R, de Béthune MP, Himmel DM, Das K, ... Arnold E, et al. 4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones: in vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains. Journal of Medicinal Chemistry. 48: 1948-64. PMID 15771439 DOI: 10.1021/Jm0408621 |
0.382 |
|
| 2005 |
Heeres J, de Jonge MR, Koymans LM, Daeyaert FF, Vinkers M, Van Aken KJ, Arnold E, Das K, Kilonda A, Hoornaert GJ, Compernolle F, Cegla M, Azzam RA, Andries K, de Béthune MP, et al. Design, synthesis, and SAR of a novel pyrazinone series with non-nucleoside HIV-1 reverse transcriptase inhibitory activity. Journal of Medicinal Chemistry. 48: 1910-8. PMID 15771435 DOI: 10.1021/Jm040829E |
0.436 |
|
| 2005 |
Janssen PA, Lewi PJ, Arnold E, Daeyaert F, de Jonge M, Heeres J, Koymans L, Vinkers M, Guillemont J, Pasquier E, Kukla M, Ludovici D, Andries K, de Béthune MP, Pauwels R, et al. In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine). Journal of Medicinal Chemistry. 48: 1901-9. PMID 15771434 DOI: 10.1021/Jm040840E |
0.679 |
|
| 2005 |
Das K, Lewi PJ, Hughes SH, Arnold E. Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors. Progress in Biophysics and Molecular Biology. 88: 209-31. PMID 15572156 DOI: 10.1016/J.Pbiomolbio.2004.07.001 |
0.477 |
|
| 2005 |
Arnold E, Frenkel YV, Oren DA, Hughes SA, Elsasser DA, Clark Jr AD, Velasco PA, Ding J, Arnold GF. Structure-based vaccine design of human rhinovirus: HIV chimeras as candidate AIDS vaccines Acta Crystallographica Section a Foundations of Crystallography. 61: c51-c51. DOI: 10.1107/S0108767305097874 |
0.622 |
|
| 2005 |
Das K, Clark AD, Lewi PJ, Hughes SH, Janssen PAJ, Arnold E. Structure-Based Design of New AIDS Drugs: Overcoming Drug Resistance Acta Crystallographica Section A. 61: 119-119. DOI: 10.1107/S0108767305094973 |
0.346 |
|
| 2005 |
Himmel DM, Sarafianos SG, Dharmasena S, Hossain M, McCoy-Simandle K, Clark PK, Clark Jr AD, Knight JL, Levy RM, Hughes SH, Parniak MA, Arnold E. X-ray structure for an RNase H inhibitor bound to HIV-1 reverse transcriptase Acta Crystallographica Section a Foundations of Crystallography. 61: c249-c249. DOI: 10.1107/S0108767305089397 |
0.411 |
|
| 2005 |
Frenkel YV, Das K, Clark AD, Lewi PJ, Arnold E. Hydrophobic drug aggregates: structure and biology Acta Crystallographica Section a Foundations of Crystallography. 61: c416-c416. DOI: 10.1107/S0108767305082395 |
0.617 |
|
| 2004 |
Sarafianos SG, Das K, Hughes SH, Arnold E. Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases. Current Opinion in Structural Biology. 14: 716-30. PMID 15582396 DOI: 10.1016/J.Sbi.2004.10.013 |
0.447 |
|
| 2004 |
Boyer PL, Imamichi T, Sarafianos SG, Arnold E, Hughes SH. Effects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision. Journal of Virology. 78: 9987-97. PMID 15331732 DOI: 10.1128/JVI.78.18.9987-9997.2004 |
0.316 |
|
| 2004 |
Sarafianos SG, Hughes SH, Arnold E. Designing anti-AIDS drugs targeting the major mechanism of HIV-1 RT resistance to nucleoside analog drugs. The International Journal of Biochemistry & Cell Biology. 36: 1706-15. PMID 15183339 DOI: 10.1016/J.Biocel.2004.02.027 |
0.456 |
|
| 2004 |
Xu X, Zhao J, Xu Z, Peng B, Huang Q, Arnold E, Ding J. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. The Journal of Biological Chemistry. 279: 33946-57. PMID 15173171 DOI: 10.1074/Jbc.M404298200 |
0.321 |
|
| 2004 |
Das K, Clark AD, Lewi PJ, Heeres J, De Jonge MR, Koymans LM, Vinkers HM, Daeyaert F, Ludovici DW, Kukla MJ, De Corte B, Kavash RW, Ho CY, Ye H, Lichtenstein MA, ... ... Arnold E, et al. Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. Journal of Medicinal Chemistry. 47: 2550-60. PMID 15115397 DOI: 10.1021/jm030558s |
0.363 |
|
| 2004 |
Tuske S, Sarafianos SG, Clark AD, Ding J, Naeger LK, White KL, Miller MD, Gibbs CS, Boyer PL, Clark P, Wang G, Gaffney BL, Jones RA, Jerina DM, Hughes SH, Arnold E, et al. Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir. Nature Structural & Molecular Biology. 11: 469-74. PMID 15107837 DOI: 10.1038/Nsmb760 |
0.473 |
|
| 2004 |
Das K, Acton T, Chiang Y, Shih L, Arnold E, Montelione GT. Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site. Proceedings of the National Academy of Sciences of the United States of America. 101: 4041-6. PMID 14999102 DOI: 10.1073/Pnas.0400189101 |
0.344 |
|
| 2004 |
Scott P, Arnold E, Evans B, Pozniak A, Moyle G, Shahmenesh M, White D, Shirley J, Cane P, Pillay D. Surveillance of HIV antiretroviral drug resistance in treated individuals in England: 1998-2000. The Journal of Antimicrobial Chemotherapy. 53: 469-73. PMID 14749345 DOI: 10.1093/jac/dkh102 |
0.322 |
|
| 2004 |
Yu Y, Liu Y, Shen N, Xu X, Xu F, Jia J, Jin Y, Arnold E, Ding J. Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity. The Journal of Biological Chemistry. 279: 8378-88. PMID 14660560 DOI: 10.1074/Jbc.M311284200 |
0.337 |
|
| 2004 |
Yu Y, Liu Y, Shen N, Xu X, Xu F, Jia J, Jin Y, Arnold E, Ding J. Crystal Structure of Human Tryptophanyl-tRNA Synthetase Catalytic Fragment Journal of Biological Chemistry. 279: 8378-8388. DOI: 10.2210/Pdb1O5T/Pdb |
0.337 |
|
| 2003 |
Xu X, Liu Y, Weiss S, Arnold E, Sarafianos SG, Ding J. Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design. Nucleic Acids Research. 31: 7117-30. PMID 14654687 DOI: 10.1093/Nar/Gkg916 |
0.386 |
|
| 2003 |
Delaney WE, Yang H, Westland CE, Das K, Arnold E, Gibbs CS, Miller MD, Xiong S. The hepatitis B virus polymerase mutation rtV173L is selected during lamivudine therapy and enhances viral replication in vitro. Journal of Virology. 77: 11833-41. PMID 14557667 DOI: 10.1128/Jvi.77.21.11833-11841.2003 |
0.313 |
|
| 2003 |
Lewi PJ, de Jonge M, Daeyaert F, Koymans L, Vinkers M, Heeres J, Janssen PA, Arnold E, Das K, Clark AD, Hughes SH, Boyer PL, de Béthune MP, Pauwels R, Andries K, et al. On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data. Journal of Computer-Aided Molecular Design. 17: 129-34. PMID 13677481 DOI: 10.1023/A:1025313705564 |
0.378 |
|
| 2003 |
Xu Z, Liu Y, Yang Y, Jiang W, Arnold E, Ding J. Crystal structure of D-Hydantoinase from Burkholderia pickettii at a resolution of 2.7 Angstroms: insights into the molecular basis of enzyme thermostability. Journal of Bacteriology. 185: 4038-49. PMID 12837777 DOI: 10.1128/Jb.185.14.4038-4049.2003 |
0.318 |
|
| 2003 |
Sarafianos SG, Clark AD, Tuske S, Squire CJ, Das K, Sheng D, Ilankumaran P, Ramesha AR, Kroth H, Sayer JM, Jerina DM, Boyer PL, Hughes SH, Arnold E. Trapping HIV-1 reverse transcriptase before and after translocation on DNA. The Journal of Biological Chemistry. 278: 16280-8. PMID 12554739 DOI: 10.1074/Jbc.M212911200 |
0.356 |
|
| 2002 |
Skillman AG, Maurer KW, Roe DC, Stauber MJ, Eargle D, Ewing TJ, Muscate A, Davioud-Charvet E, Medaglia MV, Fisher RJ, Arnold E, Gao HQ, Buckheit R, Boyer PL, Hughes SH, et al. A novel mechanism for inhibition of HIV-1 reverse transcriptase. Bioorganic Chemistry. 30: 443-58. PMID 12642128 DOI: 10.1016/S0045-2068(02)00502-3 |
0.358 |
|
| 2002 |
Boyer PL, Sarafianos SG, Arnold E, Hughes SH. Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision. Journal of Virology. 76: 9143-51. PMID 12186898 |
0.304 |
|
| 2002 |
Ding J, Smith AD, Geisler SC, Ma X, Arnold GF, Arnold E. Crystal structure of a human rhinovirus that displays part of the HIV-1 V3 loop and induces neutralizing antibodies against HIV-1. Structure (London, England : 1993). 10: 999-1011. PMID 12121655 DOI: 10.1016/S0969-2126(02)00793-1 |
0.431 |
|
| 2002 |
Tian Y, Ramesh CV, Ma X, Naqvi S, Patel T, Cenizal T, Tiscione M, Diaz K, Crea T, Arnold E, Arnold GF, Taylor JW. Structure−affinity relationships in the gp41 ELDKWA epitope for the HIV-1 neutralizing monoclonal antibody 2F5: effects of side-chain and backbone modifications and conformational constraints Journal of Peptide Research. 59: 264-276. PMID 12010517 DOI: 10.1034/J.1399-3011.2002.02988.X |
0.347 |
|
| 2001 |
Ludovici DW, De Corte BL, Kukla MJ, Ye H, Ho CY, Lichtenstein MA, Kavash RW, Andries K, de Béthune MP, Azijn H, Pauwels R, Lewi PJ, Heeres J, Koymans LM, de Jonge MR, ... ... Arnold E, et al. Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues. Bioorganic & Medicinal Chemistry Letters. 11: 2235-9. PMID 11527705 |
0.341 |
|
| 2001 |
Ludovici DW, Kavash RW, Kukla MJ, Ho CY, Ye H, De Corte BL, Andries K, de Béthune MP, Azijn H, Pauwels R, Moereels HE, Heeres J, Koymans LM, de Jonge MR, Van Aken KJ, ... ... Arnold E, et al. Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues. Bioorganic & Medicinal Chemistry Letters. 11: 2229-34. PMID 11527704 |
0.32 |
|
| 2001 |
Tachedjian G, Orlova M, Sarafianos SG, Arnold E, Goff SP. Nonnucleoside reverse transcriptase inhibitors are chemical enhancers of dimerization of the HIV type 1 reverse transcriptase. Proceedings of the National Academy of Sciences of the United States of America. 98: 7188-93. PMID 11416202 DOI: 10.1073/pnas.121055998 |
0.362 |
|
| 2001 |
Hsiou Y, Ding J, Das K, Clark AD, Boyer PL, Lewi P, Janssen PA, Kleim JP, Rösner M, Hughes SH, Arnold E. The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance. Journal of Molecular Biology. 309: 437-45. PMID 11371163 DOI: 10.1006/jmbi.2001.4648 |
0.387 |
|
| 2001 |
Boyer PL, Sarafianos SG, Arnold E, Hughes SH. Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase. Journal of Virology. 75: 4832-42. PMID 11312355 DOI: 10.1128/JVI.75.10.4832-4842.2001 |
0.317 |
|
| 2000 |
Gao HQ, Boyer PL, Sarafianos SG, Arnold E, Hughes SH. The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase. Journal of Molecular Biology. 300: 403-18. PMID 10873473 DOI: 10.1006/jmbi.2000.3823 |
0.368 |
|
| 1999 |
Madrid M, Jacobo-Molina A, Ding J, Arnold E. Major subdomain rearrangement in HIV-1 reverse transcriptase simulated by molecular dynamics. Proteins. 35: 332-337. PMID 10328268 DOI: 10.1002/(Sici)1097-0134(19990515)35:3<332::Aid-Prot7>3.0.Co;2-R |
0.376 |
|
| 1999 |
Zhang A, Geisler SC, Smith AD, Resnick DA, Li ML, Wang CY, Looney DJ, Wong-Staal F, Arnold E, Arnold GF. A disulfide-bound HIV-1 V3 loop sequence on the surface of human rhinovirus 14 induces neutralizing responses against HIV-1. Biological Chemistry. 380: 365-74. PMID 10223339 DOI: 10.1515/Bc.1999.048 |
0.408 |
|
| 1996 |
Kleim JP, Rösner M, Winkler I, Paessens A, Kirsch R, Hsiou Y, Arnold E, Riess G. Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants. Proceedings of the National Academy of Sciences of the United States of America. 93: 34-8. PMID 8552634 DOI: 10.1073/Pnas.93.1.34 |
0.458 |
|
| 1996 |
Ding J, Das K, Hsiou Y, Jacobo-Molina A, Hughes SH, Arnold E. Refined structure of HIV-1 reverse transcriptase complexed with a double-stranded DNA and an antibody Fab fragment at 2.8 Å resolution Acta Crystallographica Section A. 52: 155-155. DOI: 10.1107/S010876739609304X |
0.408 |
|
| 1996 |
Arnold E, Resnick DA, Ding J, Geisler SC, Kamer G, Arnold GF. Structural studies of an HRV 14:HIV-1 V3 loop chimera that induces neutralizing antibodies against HIV-1 Acta Crystallographica Section A. 52: 180-180. DOI: 10.1107/S0108767396092082 |
0.422 |
|
| 1996 |
Hsiou Y, Ding J, Das K, Hughes SH, Arnold E. Non-nucleoside RT inhibitors give HIV-1 RT a crooked back Acta Crystallographica Section A. 52: 234-235. DOI: 10.1107/S0108767396090010 |
0.425 |
|
| 1996 |
Arnold E. Insights into DNA polymerization mechanism and drug design from structural studies of the aids virus reverse transcriptase Faseb Journal. 10. |
0.314 |
|
| 1995 |
Resnick DA, Smith AD, Gesiler SC, Zhang A, Arnold E, Arnold GF. Chimeras from a human rhinovirus 14-human immunodeficiency virus type 1 (HIV-1) V3 loop seroprevalence library induce neutralizing responses against HIV-1. Journal of Virology. 69: 2406-11. PMID 7884887 DOI: 10.1128/Jvi.69.4.2406-2411.1995 |
0.408 |
|
| 1994 |
Boyer PL, Ding J, Arnold E, Hughes SH. Subunit specificity of mutations that confer resistance to nonnucleoside inhibitors in human immunodeficiency virus type 1 reverse transcriptase. Antimicrobial Agents and Chemotherapy. 38: 1909-1914. PMID 7529011 DOI: 10.1128/Aac.38.9.1909 |
0.411 |
|
| 1994 |
Tantillo C, Ding J, Jacobo-Molina A, Nanni RG, Boyer PL, Hughes SH, Pauwels R, Andries K, Janssen PA, Arnold E. Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance. Journal of Molecular Biology. 243: 369-87. PMID 7525966 DOI: 10.1006/jmbi.1994.1665 |
0.38 |
|
| 1994 |
Boyer PL, Tantillo C, Jacobo-Molina A, Nanni RG, Ding J, Arnold E, Hughes SH. Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not. Proceedings of the National Academy of Sciences of the United States of America. 91: 4882-6. PMID 7515182 DOI: 10.1073/pnas.91.11.4882 |
0.34 |
|
| 1993 |
Ding J, Jacobo-Molina A, Nanni RG, Lu X, Tantillo C, Clark Jr AD, Hughes SH, Arnold E. Structure of HIV-1 reverse transcriptase/dsDNA/Fab complex: protein-DNA interactions and structure of the polymerase active site Acta Crystallographica Section a Foundations of Crystallography. 49: c154-c155. DOI: 10.1107/S0108767378095586 |
0.438 |
|
| 1985 |
Montelione G, Arnold E, Meinwald Y, Stimson E, Denton J, Huang S, Clardy J, Scheraga H. Additions and Corrections - Chain-Folding Initiation Structures in Ribonuclease A: Conformational Analysis of trans-Ac-Asn-Pro-Tyr NHMe and trans-Ac-Tyr-Pro-Asn-NHMe in Water and in the Solid State Journal of the American Chemical Society. 107: 1457-1457. DOI: 10.1021/Ja00291A602 |
0.336 |
|
| 1985 |
MONTELIONE GT, ARNOLD E, MEINWALD YC, STIMSON ER, DENTON JB, HUANG S, CLARDY J, SCHERAGA HA. ChemInform Abstract: Chain-Folding Initiation Structures in Ribonuclease A: Conformational Analysis of trans-Ac-Asn-Pro-Tyr-NHMe (I) und trans-Ac-Tyr-Pro-Asn-NHMe (II) in Water und in the Solid State. Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198515079 |
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| 1984 |
Montelione GT, Arnold E, Meinwald YC, Stimson ER, Denton JB, Huang SG, Clardy J, Scheraga HA. Chain-folding initiation structures in ribonuclease A: conformational analysis of trans-Ac-Asn-Pro-Tyr-NHMe and trans-Ac-Tyr-Pro-Asn-NHMe in water and in the solid state Journal of the American Chemical Society. 106: 7959-7969. DOI: 10.1021/Ja00337A052 |
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| 1981 |
Balitz DM, O'Herron FA, Bush J, Vyas DM, Nettleton DE, Grulich RE, Bradner WT, Doyle TW, Arnold E, Clardy J. Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E. The Journal of Antibiotics. 34: 1544-55. PMID 7344705 DOI: 10.7164/Antibiotics.34.1544 |
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