Gerald W. Dorn - Publications

Affiliations: 
University of Cincinnati, Cincinnati, OH 
Area:
Pharmacology, Molecular Biology

137 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Franco A, Li J, Kelly DP, Hershberger RE, Marian AJ, Lewis RM, Song M, Dang X, Schmidt AD, Mathyer ME, Edwards JR, Strong CG, Dorn GW. A human mitofusin 2 mutation can cause mitophagic cardiomyopathy. Elife. 12. PMID 37910431 DOI: 10.7554/eLife.84235  0.309
2023 Nichtová Z, Fernandez-Sanz C, De La Fuente S, Yuan Y, Hurst S, Lanvermann S, Tsai HY, Weaver D, Baggett A, Thompson C, Bouchet-Marquis C, Várnai P, Seifert EL, Dorn GW, Sheu SS, et al. Enhanced Mitochondria-SR Tethering Triggers Adaptive Cardiac Muscle Remodeling. Circulation Research. PMID 37057625 DOI: 10.1161/CIRCRESAHA.122.321833  0.312
2020 Joshi AU, Minhas PS, Liddelow SA, Haileselassie B, Andreasson KI, Dorn GW, Mochly-Rosen D. Author Correction: Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration. Nature Neuroscience. PMID 33324000 DOI: 10.1038/s41593-020-00774-5  0.392
2020 Dorn GW. Mitofusin 2 Dysfunction and Disease in Mice and Men. Frontiers in Physiology. 11: 782. PMID 32733278 DOI: 10.3389/Fphys.2020.00782  0.38
2020 Hernandez-Resendiz S, Prunier F, Girao H, Dorn G, Hausenloy DJ. Targeting mitochondrial fusion and fission proteins for cardioprotection. Journal of Cellular and Molecular Medicine. 24: 6571-6585. PMID 32406208 DOI: 10.1111/Jcmm.15384  0.429
2020 Dorn GW. Mitofusins as mitochondrial anchors and tethers. Journal of Molecular and Cellular Cardiology. PMID 32304672 DOI: 10.1016/J.Yjmcc.2020.04.016  0.396
2020 Ballard A, Zeng R, Zarei A, Shao C, Cox L, Yan H, Franco A, Dorn GW, Faccio R, Veis DJ. The tethering function of mitofusin2 controls osteoclast differentiation by modulating the Ca2+-NFATC1 axis. The Journal of Biological Chemistry. PMID 32165499 DOI: 10.1074/Jbc.Ra119.012023  0.369
2019 Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn GW, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, et al. Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop Circulation. 140: 1205-1216. PMID 31769940 DOI: 10.1161/Circulationaha.119.040551  0.398
2019 Joshi AU, Minhas PS, Liddelow SA, Haileselassie B, Andreasson KI, Dorn GW, Mochly-Rosen D. Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration. Nature Neuroscience. 22: 1635-1648. PMID 31551592 DOI: 10.1038/S41593-019-0486-0  0.503
2019 Zhou Y, Carmona S, Muhammad AKMG, Bell S, Landeros J, Vazquez M, Ho R, Franco A, Lu B, Dorn GW, Wang S, Lutz CM, Baloh RH. Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model. The Journal of Clinical Investigation. 130. PMID 30882371 DOI: 10.1172/Jci124194  0.366
2019 Gustafsson ÅB, Dorn GW. Evolving and Expanding the Roles of Mitophagy as a Homeostatic and Pathogenic Process. Physiological Reviews. 99: 853-892. PMID 30540226 DOI: 10.1152/Physrev.00005.2018  0.381
2019 Dorn GW. Evolving Concepts of Mitochondrial Dynamics. Annual Review of Physiology. 81: 1-17. PMID 30256725 DOI: 10.1146/Annurev-Physiol-020518-114358  0.405
2018 Dorn GW. Cardiac-specific research platforms engender novel insights into mitochondrial dynamism. Current Opinion in Physiology. 3: 110-115. PMID 30467553 DOI: 10.1016/J.Cophys.2018.03.006  0.436
2018 Von Schulze A, McCoin CS, Onyekere C, Allen J, Geiger P, Dorn GW, Morris EM, Thyfault JP. Hepatic mitochondrial adaptations to physical activity: impact of sexual dimorphism, PGC1α, and BNIP3 mediated mitophagy. The Journal of Physiology. PMID 30062822 DOI: 10.1113/Jp276539  0.329
2018 Franco A, Zhang L, Matkovich SJ, Kovacs A, Dorn GW. G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts. Journal of Molecular and Cellular Cardiology. PMID 29969579 DOI: 10.1016/J.Yjmcc.2018.06.009  0.429
2018 Rocha AG, Franco A, Krezel AM, Rumsey JM, Alberti JM, Knight WC, Biris N, Zacharioudakis E, Janetka JW, Baloh RH, Kitsis RN, Mochly-Rosen D, Townsend RR, Gavathiotis E, Dorn GW. MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A. Science (New York, N.Y.). 360: 336-341. PMID 29674596 DOI: 10.1126/Science.Aao1785  0.377
2017 Song M, Franco A, Fleischer JA, Zhang L, Dorn GW. Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. Cell Metabolism. PMID 29107503 DOI: 10.1016/J.Cmet.2017.09.023  0.453
2017 Beikoghli Kalkhoran S, Hall AR, White IJ, Cooper J, Fan Q, Ong SB, Hernández-Reséndiz S, Cabrera-Fuentes H, Chinda K, Chakraborty B, Dorn GW, Yellon DM, Hausenloy DJ. Assessing the effects of mitofusin 2 deficiency in the adult heart using 3D electron tomography. Physiological Reports. 5. PMID 28904083 DOI: 10.14814/Phy2.13437  0.334
2017 Yanamandala M, Zhu W, Garry DJ, Kamp TJ, Hare JM, Jun HW, Yoon YS, Bursac N, Prabhu SD, Dorn GW, Bolli R, Kitsis RN, Zhang J. Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering. Journal of the American College of Cardiology. 70: 766-775. PMID 28774384 DOI: 10.1016/J.Jacc.2017.06.012  0.349
2016 Franco A, Kitsis RN, Fleischer JA, Gavathiotis E, Kornfeld OS, Gong G, Biris N, Benz A, Qvit N, Donnelly SK, Chen Y, Mennerick S, Hodgson L, Mochly-Rosen D, Dorn GW. Correcting mitochondrial fusion by manipulating mitofusin conformations. Nature. PMID 27775718 DOI: 10.1038/Nature20156  0.372
2016 Naon D, Zaninello M, Giacomello M, Varanita T, Grespi F, Lakshminaranayan S, Serafini A, Semenzato M, Herkenne S, Hernández-Alvarez MI, Zorzano A, De Stefani D, Dorn GW, Scorrano L. Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether. Proceedings of the National Academy of Sciences of the United States of America. 113: 11249-11254. PMID 27647893 DOI: 10.1073/Pnas.1606786113  0.372
2016 Tol MJ, Ottenhoff R, van Eijk M, Zelcer N, Aten J, Houten SM, Geerts D, van Roomen C, Bierlaagh MC, Scheij S, Hoeksema MA, Aerts JM, Bogan JS, Dorn GW, Argmann CA, et al. A PPARγ-Bnip3 axis couples adipose mitochondrial fusion-fission balance to systemic insulin sensitivity. Diabetes. PMID 27325287 DOI: 10.2337/Db16-0243  0.33
2016 Dorn GW. Tension-Time Integrals and Genetic Cardiomyopathy: The Force Is with You. Cell. 165: 1049-1050. PMID 27203107 DOI: 10.1016/J.Cell.2016.04.036  0.318
2016 Murphy E, Ardehali H, Balaban RS, DiLisa F, Dorn GW, Kitsis RN, Otsu K, Ping P, Rizzuto R, Sack MN, Wallace D, Youle RJ. Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association. Circulation Research. 118: 1960-91. PMID 27126807 DOI: 10.1161/Res.0000000000000104  0.405
2016 Dorn GW. Central Parkin: The evolving role of Parkin in the heart. Biochimica Et Biophysica Acta. 1857: 1307-1312. PMID 26992930 DOI: 10.1016/J.Bbabio.2016.03.014  0.429
2016 Dorn GW. Jurassic PARK2: You eat your mitochondria, and you are what your mitochondria eat. Autophagy. 12: 610-1. PMID 26854000 DOI: 10.1080/15548627.2016.1143210  0.396
2016 Dorn GW. Parkin-dependent mitophagy in the heart. Journal of Molecular and Cellular Cardiology. 95: 42-9. PMID 26611886 DOI: 10.1016/J.Yjmcc.2015.11.023  0.464
2016 Dorn GW. Parkin-mediated mitophagy and mitochondrial reprogramming Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1857: e3-e4. DOI: 10.1016/J.Bbabio.2016.04.023  0.362
2015 Gong G, Song M, Csordas G, Kelly DP, Matkovich SJ, Dorn GW. Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice. Science (New York, N.Y.). 350: aad2459. PMID 26785495 DOI: 10.1126/Science.Aad2459  0.445
2015 Matkovich SJ, Dorn GW, Grossenheider TC, Hecker PA. Cardiac Disease Status Dictates Functional mRNA Targeting Profiles of Individual MicroRNAs. Circulation. Cardiovascular Genetics. 8: 774-84. PMID 26553694 DOI: 10.1161/Circgenetics.115.001237  0.341
2015 Dorn GW, Vega RB, Kelly DP. Mitochondrial biogenesis and dynamics in the developing and diseased heart. Genes & Development. 29: 1981-91. PMID 26443844 DOI: 10.1101/Gad.269894.115  0.418
2015 Song M, Gong G, Burelle Y, Gustafsson ÅB, Kitsis RN, Matkovich SJ, Dorn GW. Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circulation Research. 117: 346-51. PMID 26038571 DOI: 10.1161/Circresaha.117.306859  0.484
2015 Shirihai OS, Song M, Dorn GW. How mitochondrial dynamism orchestrates mitophagy. Circulation Research. 116: 1835-49. PMID 25999423 DOI: 10.1161/Circresaha.116.306374  0.442
2015 Song M, Matkovich SJ, Zhang Y, Hammer DJ, Dorn GW. Combined cardiomyocyte PKCδ and PKCε gene deletion uncovers their central role in restraining developmental and reactive heart growth. Science Signaling. 8: ra39. PMID 25900833 DOI: 10.1126/Scisignal.Aaa1855  0.417
2015 Dorn GW. Mitochondrial dynamism and heart disease: changing shape and shaping change. Embo Molecular Medicine. 7: 865-77. PMID 25861797 DOI: 10.15252/Emmm.201404575  0.438
2015 Devaux Y, Zangrando J, Schroen B, Creemers EE, Pedrazzini T, Chang CP, Dorn GW, Thum T, Heymans S. Long noncoding RNAs in cardiac development and ageing. Nature Reviews. Cardiology. 12: 415-25. PMID 25855606 DOI: 10.1038/Nrcardio.2015.55  0.362
2015 Song M, Dorn GW. Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart. Cell Metabolism. 21: 195-205. PMID 25651174 DOI: 10.1016/J.Cmet.2014.12.019  0.409
2015 Dorn GW. Cardiac regeneration - Alchemy, science, and a wee bit of magic? Journal of Molecular and Cellular Cardiology. 81: 10-1. PMID 25647276 DOI: 10.1016/J.Yjmcc.2015.01.016  0.316
2015 Westenbrink BD, Ling H, Divakaruni AS, Gray CB, Zambon AC, Dalton ND, Peterson KL, Gu Y, Matkovich SJ, Murphy AN, Miyamoto S, Dorn GW, Heller Brown J. Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensation. Circulation Research. 116: e28-39. PMID 25605649 DOI: 10.1161/Circresaha.116.304682  0.318
2015 Song M, Mihara K, Chen Y, Scorrano L, Dorn GW. Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts. Cell Metabolism. 21: 273-286. PMID 25600785 DOI: 10.1016/j.cmet.2014.12.011  0.32
2015 Bhandari P, Song M, Dorn GW. Dissociation of mitochondrial from sarcoplasmic reticular stress in Drosophila cardiomyopathy induced by molecularly distinct mitochondrial fusion defects. Journal of Molecular and Cellular Cardiology. 80: 71-80. PMID 25555803 DOI: 10.1016/j.yjmcc.2014.12.018  0.332
2015 Dorn GW, Kitsis RN. The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble. Circulation Research. 116: 167-82. PMID 25323859 DOI: 10.1161/Circresaha.116.303554  0.414
2015 Dorn GW, Song M, Walsh K. Functional implications of mitofusin 2-mediated mitochondrial-SR tethering. Journal of Molecular and Cellular Cardiology. 78: 123-8. PMID 25252175 DOI: 10.1016/J.Yjmcc.2014.09.015  0.402
2015 Dorn GW, Song M, VanHook AM. Science SignalingPodcast: 21 April 2015 Science Signaling. 8: pc10-pc10. DOI: 10.1126/Scisignal.Aab2834  0.399
2014 Dhingra R, Margulets V, Chowdhury SR, Thliveris J, Jassal D, Fernyhough P, Dorn GW, Kirshenbaum LA. Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling. Proceedings of the National Academy of Sciences of the United States of America. 111: E5537-44. PMID 25489073 DOI: 10.1073/Pnas.1414665111  0.448
2014 Matkovich SJ, Edwards JR, Grossenheider TC, de Guzman Strong C, Dorn GW. Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs. Proceedings of the National Academy of Sciences of the United States of America. 111: 12264-9. PMID 25071214 DOI: 10.1073/Pnas.1410622111  0.384
2014 Song M, Chen Y, Gong G, Murphy E, Rabinovitch PS, Dorn GW. Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy. Circulation Research. 115: 348-53. PMID 24874428 DOI: 10.1161/Circresaha.115.304384  0.342
2014 Dorn GW, Matkovich SJ. Menage a Trois: intimate relationship among a microRNA, long noncoding RNA, and mRNA. Circulation Research. 114: 1362-5. PMID 24763458 DOI: 10.1161/Circresaha.114.303786  0.338
2014 Chen S, Puthanveetil P, Feng B, Matkovich SJ, Dorn GW, Chakrabarti S. Cardiac miR-133a overexpression prevents early cardiac fibrosis in diabetes. Journal of Cellular and Molecular Medicine. 18: 415-21. PMID 24428157 DOI: 10.1111/Jcmm.12218  0.34
2014 Bhandari P, Song M, Chen Y, Burelle Y, Dorn GW. Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin. Circulation Research. 114: 257-65. PMID 24192653 DOI: 10.1161/Circresaha.114.302734  0.378
2014 Chen Y, Sparks M, Bhandari P, Matkovich SJ, Dorn GW. Mitochondrial genome linearization is a causative factor for cardiomyopathy in mice and Drosophila. Antioxidants & Redox Signaling. 21: 1949-59. PMID 23909626 DOI: 10.1089/Ars.2013.5432  0.428
2013 Kasahara A, Cipolat S, Chen Y, Dorn GW, Scorrano L. Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling. Science (New York, N.Y.). 342: 734-7. PMID 24091702 DOI: 10.1126/Science.1241359  0.414
2013 Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn GW, Trimarco B, Iaccarino G. Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages. Febs Letters. 587: 3487-94. PMID 24036448 DOI: 10.1016/J.Febslet.2013.09.002  0.345
2013 Fan Q, Chen M, Zuo L, Shang X, Huang MZ, Ciccarelli M, Raake P, Brinks H, Chuprun KJ, Dorn GW, Koch WJ, Gao E. Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway. Plos One. 8: e66234. PMID 23805205 DOI: 10.1371/Journal.Pone.0066234  0.394
2013 Vasudevan NT, Mohan ML, Gupta MK, Martelli EE, Hussain AK, Qin Y, Chandrasekharan UM, Young D, Feldman AM, Sen S, Dorn GW, Dicorleto PE, Naga Prasad SV. Gβγ-independent recruitment of G-protein coupled receptor kinase 2 drives tumor necrosis factor α-induced cardiac β-adrenergic receptor dysfunction. Circulation. 128: 377-87. PMID 23785004 DOI: 10.1161/Circulationaha.113.003183  0.325
2013 Matkovich SJ, Hu Y, Dorn GW. Regulation of cardiac microRNAs by cardiac microRNAs. Circulation Research. 113: 62-71. PMID 23625950 DOI: 10.1161/Circresaha.113.300975  0.306
2013 Chen Y, Dorn GW. PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science (New York, N.Y.). 340: 471-5. PMID 23620051 DOI: 10.1126/Science.1231031  0.45
2013 Dorn GW. Mitochondrial dynamism and cardiac fate--a personal perspective. Circulation Journal : Official Journal of the Japanese Circulation Society. 77: 1370-9. PMID 23615052 DOI: 10.1253/Circj.Cj-13-0453  0.444
2013 Chen Y, Decker KF, Zheng D, Matkovich SJ, Jia L, Dorn GW. A nucleus-targeted alternately spliced Nix/Bnip3L protein isoform modifies nuclear factor κB (NFκB)-mediated cardiac transcription. The Journal of Biological Chemistry. 288: 15455-65. PMID 23603904 DOI: 10.1074/Jbc.M113.452342  0.423
2013 Cao DJ, Jiang N, Blagg A, Johnstone JL, Gondalia R, Oh M, Luo X, Yang KC, Shelton JM, Rothermel BA, Gillette TG, Dorn GW, Hill JA. Mechanical unloading activates FoxO3 to trigger Bnip3-dependent cardiomyocyte atrophy. Journal of the American Heart Association. 2: e000016. PMID 23568341 DOI: 10.1161/Jaha.113.000016  0.436
2013 Dorn GW, Maack C. SR and mitochondria: calcium cross-talk between kissing cousins. Journal of Molecular and Cellular Cardiology. 55: 42-9. PMID 22902320 DOI: 10.1016/J.Yjmcc.2012.07.015  0.393
2013 Dorn GW. Mitochondrial dynamics in heart disease. Biochimica Et Biophysica Acta. 1833: 233-41. PMID 22450031 DOI: 10.1016/j.bbamcr.2012.03.008  0.35
2012 Dorn GW. Inflame on!: mitochondrial escape provokes cytokine storms that doom the heart. Circulation Research. 111: 271-3. PMID 22821906 DOI: 10.1161/Circresaha.112.275867  0.397
2012 Chen Y, Csordás G, Jowdy C, Schneider TG, Csordás N, Wang W, Liu Y, Kohlhaas M, Meiser M, Bergem S, Nerbonne JM, Dorn GW, Maack C. Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk. Circulation Research. 111: 863-75. PMID 22777004 DOI: 10.1161/Circresaha.112.266585  0.369
2012 Tao W, Shi J, Dorn GW, Wei L, Rubart M. Spatial variability in T-tubule and electrical remodeling of left ventricular epicardium in mouse hearts with transgenic Gαq overexpression-induced pathological hypertrophy. Journal of Molecular and Cellular Cardiology. 53: 409-19. PMID 22728217 DOI: 10.1016/J.Yjmcc.2012.06.006  0.367
2012 Lee MJ, Kim DE, Zakrzewska A, Yoo YD, Kim SH, Kim ST, Seo JW, Lee YS, Dorn GW, Oh U, Kim BY, Kwon YT. Characterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytes. The Journal of Biological Chemistry. 287: 24043-52. PMID 22577142 DOI: 10.1074/Jbc.M112.364117  0.356
2012 Glick D, Zhang W, Beaton M, Marsboom G, Gruber M, Simon MC, Hart J, Dorn GW, Brady MJ, Macleod KF. BNip3 regulates mitochondrial function and lipid metabolism in the liver. Molecular and Cellular Biology. 32: 2570-84. PMID 22547685 DOI: 10.1128/Mcb.00167-12  0.362
2012 Raake PW, Zhang X, Vinge LE, Brinks H, Gao E, Jaleel N, Li Y, Tang M, Most P, Dorn GW, Houser SR, Katus HA, Chen X, Koch WJ. Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction. Circulation. 125: 2108-18. PMID 22496128 DOI: 10.1161/Circulationaha.111.044255  0.324
2012 Whelan RS, Konstantinidis K, Wei AC, Chen Y, Reyna DE, Jha S, Yang Y, Calvert JW, Lindsten T, Thompson CB, Crow MT, Gavathiotis E, Dorn GW, O'Rourke B, Kitsis RN. Bax regulates primary necrosis through mitochondrial dynamics. Proceedings of the National Academy of Sciences of the United States of America. 109: 6566-71. PMID 22493254 DOI: 10.1073/Pnas.1201608109  0.398
2012 Zhu W, Petrashevskaya N, Ren S, Zhao A, Chakir K, Gao E, Chuprun JK, Wang Y, Talan M, Dorn GW, Lakatta EG, Koch WJ, Feldman AM, Xiao RP. Gi-biased β2AR signaling links GRK2 upregulation to heart failure. Circulation Research. 110: 265-74. PMID 22179058 DOI: 10.1161/Circresaha.111.253260  0.382
2012 Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW, Trimarco B, Feliciello A, Iaccarino G. Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis. Cellular Signalling. 24: 468-75. PMID 21983013 DOI: 10.1016/J.Cellsig.2011.09.026  0.369
2012 Perez-Pomares JM, Ruiz-Villalba A, Ziogas A, Segovia JC, Ehrbar M, Munoz-Chapuli R, De La Rosa A, Dominguez JN, Hove-Madsen L, Sankova B, Sedmera D, Franco D, Aranega Jimenez A, Babaeva G, Chizh N, ... ... Dorn GW, et al. Poster session 2 Cardiovascular Research. 93: S52-S87. DOI: 10.1093/Cvr/Cvr334  0.325
2012 Dorn GW, Kitsis RN. Programmed cardiomyocyte death in heart disease Muscle. 1: 423-446. DOI: 10.1016/B978-0-12-381510-1.00031-4  0.331
2011 Cappola TP, Dorn GW. Clinical considerations of heritable factors in common heart failure. Circulation. Cardiovascular Genetics. 4: 701-9. PMID 22187448 DOI: 10.1161/Circgenetics.110.959379  0.38
2011 Chen Y, Liu Y, Dorn GW. Mitochondrial fusion is essential for organelle function and cardiac homeostasis. Circulation Research. 109: 1327-31. PMID 22052916 DOI: 10.1161/CIRCRESAHA.111.258723  0.313
2011 Zhang Y, Matkovich SJ, Duan X, Gold JI, Koch WJ, Dorn GW. Nuclear effects of G-protein receptor kinase 5 on histone deacetylase 5-regulated gene transcription in heart failure. Circulation. Heart Failure. 4: 659-68. PMID 21768220 DOI: 10.1161/Circheartfailure.111.962563  0.413
2011 Razani B, Zhang H, Schulze PC, Schilling JD, Verbsky J, Lodhi IJ, Topkara VK, Feng C, Coleman T, Kovacs A, Kelly DP, Saffitz JE, Dorn GW, Nichols CG, Semenkovich CF. Fatty acid synthase modulates homeostatic responses to myocardial stress. The Journal of Biological Chemistry. 286: 30949-61. PMID 21757749 DOI: 10.1074/Jbc.M111.230508  0.415
2011 Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW, Brown JH. RhoA protects the mouse heart against ischemia/reperfusion injury. The Journal of Clinical Investigation. 121: 3269-76. PMID 21747165 DOI: 10.1172/Jci44371  0.345
2011 Rodriguez G, Ueyama T, Ogata T, Czernuszewicz G, Tan Y, Dorn GW, Bogaev R, Amano K, Oh H, Matsubara H, Willerson JT, Marian AJ. Molecular genetic and functional characterization implicate muscle-restricted coiled-coil gene (MURC) as a causal gene for familial dilated cardiomyopathy. Circulation. Cardiovascular Genetics. 4: 349-58. PMID 21642240 DOI: 10.1161/Circgenetics.111.959866  0.377
2011 Ciccarelli M, Chuprun JK, Rengo G, Gao E, Wei Z, Peroutka RJ, Gold JI, Gumpert A, Chen M, Otis NJ, Dorn GW, Trimarco B, Iaccarino G, Koch WJ. G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia. Circulation. 123: 1953-62. PMID 21518983 DOI: 10.1161/Circulationaha.110.988642  0.417
2011 Dai DF, Johnson SC, Villarin JJ, Chin MT, Nieves-Cintrón M, Chen T, Marcinek DJ, Dorn GW, Kang YJ, Prolla TA, Santana LF, Rabinovitch PS. Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure. Circulation Research. 108: 837-46. PMID 21311045 DOI: 10.1161/Circresaha.110.232306  0.41
2011 Dorn GW, Clark CF, Eschenbacher WH, Kang MY, Engelhard JT, Warner SJ, Matkovich SJ, Jowdy CC. MARF and Opa1 control mitochondrial and cardiac function in Drosophila. Circulation Research. 108: 12-7. PMID 21148429 DOI: 10.1161/Circresaha.110.236745  0.317
2010 Dorn GW. Nix Nought Nothing: fairy tale or real deal. Journal of Molecular and Cellular Cardiology. 51: 497-500. PMID 20858501 DOI: 10.1016/j.yjmcc.2010.09.011  0.363
2010 Kang MY, Zhang Y, Matkovich SJ, Diwan A, Chishti AH, Dorn GW. Receptor-independent cardiac protein kinase Calpha activation by calpain-mediated truncation of regulatory domains. Circulation Research. 107: 903-12. PMID 20689063 DOI: 10.1161/Circresaha.110.220772  0.414
2010 Ding WX, Ni HM, Li M, Liao Y, Chen X, Stolz DB, Dorn GW, Yin XM. Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming. The Journal of Biological Chemistry. 285: 27879-90. PMID 20573959 DOI: 10.1074/Jbc.M110.119537  0.386
2010 Dorn GW. Mitochondrial pruning by Nix and BNip3: an essential function for cardiac-expressed death factors. Journal of Cardiovascular Translational Research. 3: 374-83. PMID 20559783 DOI: 10.1007/s12265-010-9174-x  0.369
2010 Matkovich SJ, Zhang Y, Van Booven DJ, Dorn GW. Deep mRNA sequencing for in vivo functional analysis of cardiac transcriptional regulators: application to Galphaq. Circulation Research. 106: 1459-67. PMID 20360248 DOI: 10.1161/Circresaha.110.217513  0.346
2010 Lymperopoulos A, Rengo G, Gao E, Ebert SN, Dorn GW, Koch WJ. Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarction Journal of Biological Chemistry. 285: 16378-16386. PMID 20351116 DOI: 10.1074/Jbc.M109.077859  0.422
2010 Dorn GW. Medicine. Refugee receptors switch sides. Science (New York, N.Y.). 327: 1586-7. PMID 20339055 DOI: 10.1126/Science.1188538  0.359
2010 Cappola TP, Li M, He J, Ky B, Gilmore J, Qu L, Keating B, Reilly M, Kim CE, Glessner J, Frackelton E, Hakonarson H, Syed F, Hindes A, Matkovich SJ, ... ... Dorn GW, et al. Common variants in HSPB7 and FRMD4B associated with advanced heart failure. Circulation. Cardiovascular Genetics. 3: 147-54. PMID 20124441 DOI: 10.1161/Circgenetics.109.898395  0.345
2010 Foyil SA, Ma X, Hill JA, Dorn GW, Diwan A. BNIP3 Induced Autophagy Contributes to Adverse Ventricular Remodeling Journal of Cardiac Failure. 16: S35. DOI: 10.1016/J.Cardfail.2010.06.119  0.355
2009 Dorn GW, Liggett SB. Mechanisms of pharmacogenomic effects of genetic variation within the cardiac adrenergic network in heart failure. Molecular Pharmacology. 76: 466-80. PMID 19491328 DOI: 10.1124/Mol.109.056572  0.37
2009 Dorn GW. Novel pharmacotherapies to abrogate postinfarction ventricular remodeling. Nature Reviews. Cardiology. 6: 283-91. PMID 19352332 DOI: 10.1038/Nrcardio.2009.12  0.392
2009 Diwan A, Matkovich SJ, Yuan Q, Zhao W, Yatani A, Brown JH, Molkentin JD, Kranias EG, Dorn GW. Endoplasmic reticulum-mitochondria crosstalk in NIX-mediated murine cell death. The Journal of Clinical Investigation. 119: 203-12. PMID 19065046 DOI: 10.1172/Jci36445  0.4
2009 Chen G, Zhou X, Pathak A, Dorn GW, Kranias EG. The human G147D-protein phosphatase 1 inhibitor-1 polymorphism is not associated with altered clinical characteristics in heart failure. Cardiology. 112: 224-31. PMID 18698139 DOI: 10.1159/000151240  0.346
2008 Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima T, Gu Y, Dalton ND, Mahata SK, Dorn GW, Brown JH, Heller-Brown J, et al. An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. The Journal of Clinical Investigation. 118: 3870-80. PMID 19033658 DOI: 10.1172/Jci34472  0.34
2008 Kardia SL, Kelly RJ, Keddache MA, Aronow BJ, Grabowski GA, Hahn HS, Case KL, Wagoner LE, Dorn GW, Liggett SB. Multiple interactions between the alpha 2C- and beta1-adrenergic receptors influence heart failure survival. Bmc Medical Genetics. 9: 93. PMID 18947427 DOI: 10.1186/1471-2350-9-93  0.36
2008 Nicolaou P, Knöll R, Haghighi K, Fan GC, Dorn GW, Hasenfub G, Kranias EG. Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects. The Journal of Biological Chemistry. 283: 33465-71. PMID 18790732 DOI: 10.1074/Jbc.M802307200  0.313
2008 Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, Degeorge BR, Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW, Koch WJ. G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure Circulation Research. 103: 413-422. PMID 18635825 DOI: 10.1161/Circresaha.107.168336  0.429
2008 Dorn GW, Matkovich SJ. Put your chips on transcriptomics. Circulation. 118: 216-8. PMID 18625903 DOI: 10.1161/Circulationaha.108.789933  0.348
2008 Dorn GW, Cresci S. The mechanistic imperative for pharmacogenomics. Pharmacogenomics. 9: 801-3. PMID 18597641 DOI: 10.2217/14622416.9.7.801  0.322
2008 Dorn GW, Diwan A. The rationale for cardiomyocyte resuscitation in myocardial salvage Journal of Molecular Medicine. 86: 1085-1095. PMID 18563379 DOI: 10.1007/s00109-008-0362-y  0.326
2008 Liggett SB, Cresci S, Kelly RJ, Syed FM, Matkovich SJ, Hahn HS, Diwan A, Martini JS, Sparks L, Parekh RR, Spertus JA, Koch WJ, Kardia SL, Dorn GW. A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nature Medicine. 14: 510-7. PMID 18425130 DOI: 10.1038/Nm1750  0.386
2008 Chen G, Zhou X, Nicolaou P, Rodriguez P, Song G, Mitton B, Pathak A, Zachariah A, Fan GC, Dorn GW, Kranias EG. A human polymorphism of protein phosphatase-1 inhibitor-1 is associated with attenuated contractile response of cardiomyocytes to beta-adrenergic stimulation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 1790-6. PMID 18192322 DOI: 10.1096/Fj.07-097428  0.381
2008 Diwan A, Yuan Q, Zhao W, Matkovich SJ, Kranias EG, Dorn GW. Nix Regulation of Sarcoplasmic Reticulum Calcium Stimulates Reactive Apoptosis through the Mitochondrial Pathway Journal of Cardiac Failure. 14: S40. DOI: 10.1016/J.Cardfail.2008.06.284  0.343
2007 Nakamura T, Colbert M, Krenz M, Molkentin JD, Hahn HS, Dorn GW, Robbins J. Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome. The Journal of Clinical Investigation. 117: 2123-32. PMID 17641779 DOI: 10.1172/Jci30756  0.42
2007 Oka T, Xu J, Kaiser RA, Melendez J, Hambleton M, Sargent MA, Lorts A, Brunskill EW, Dorn GW, Conway SJ, Aronow BJ, Robbins J, Molkentin JD. Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circulation Research. 101: 313-21. PMID 17569887 DOI: 10.1016/J.Cardfail.2007.06.236  0.323
2007 Satoh M, Matter CM, Ogita H, Takeshita K, Wang CY, Dorn GW, Liao JK. Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen. Circulation. 115: 3197-204. PMID 17562954 DOI: 10.1161/Circulationaha.106.657981  0.399
2007 Galvez AS, Diwan A, Odley AM, Hahn HS, Osinska H, Melendez JG, Robbins J, Lynch RA, Marreez Y, Dorn GW. Cardiomyocyte degeneration with calpain deficiency reveals a critical role in protein homeostasis Circulation Research. 100: 1071-1078. PMID 17332428 DOI: 10.1161/01.Res.0000261938.28365.11  0.392
2006 Matkovich SJ, Diwan A, Klanke JL, Hammer DJ, Marreez Y, Odley AM, Brunskill EW, Koch WJ, Schwartz RJ, Dorn GW. Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling. Circulation Research. 99: 996-1003. PMID 17008600 DOI: 10.1161/01.Res.0000247932.71270.2C  0.427
2006 Zhao W, Yuan Q, Qian J, Waggoner JR, Pathak A, Chu G, Mitton B, Sun X, Jin J, Braz JC, Hahn HS, Marreez Y, Syed F, Pollesello P, Annila A, ... ... Dorn GW, et al. The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling. Circulation. 113: 995-1004. PMID 16476846 DOI: 10.1161/Circulationaha.105.583351  0.354
2006 Haghighi K, Kolokathis F, Gramolini AO, Waggoner JR, Pater L, Lynch RA, Fan GC, Tsiapras D, Parekh RR, Dorn GW, MacLennan DH, Kremastinos DT, Kranias EG. A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 103: 1388-93. PMID 16432188 DOI: 10.1073/Pnas.0510519103  0.399
2005 Sadayappan S, Gulick J, Osinska H, Martin LA, Hahn HS, Dorn GW, Klevitsky R, Seidman CE, Seidman JG, Robbins J. Cardiac myosin-binding protein-C phosphorylation and cardiac function. Circulation Research. 97: 1156-63. PMID 16224063 DOI: 10.1161/01.Res.0000190605.79013.4D  0.367
2005 Miyamoto S, Howes AL, Adams JW, Dorn GW, Brown JH. Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT. The Journal of Biological Chemistry. 280: 38505-12. PMID 16061478 DOI: 10.1074/Jbc.M505223200  0.31
2005 Syed FM, Hahn HS, Odley A, Guo Y, Vallejo JG, Lynch RA, Mann DL, Bolli R, Dorn GW. Proapoptotic effects of caspase-1/interleukin-converting enzyme dominate in myocardial ischemia. Circulation Research. 96: 1103-9. PMID 15845887 DOI: 10.1161/01.Res.0000166925.45995.Ed  0.393
2004 Odley A, Hahn HS, Lynch RA, Marreez Y, Osinska H, Robbins J, Dorn GW. Regulation of cardiac contractility by Rab4-modulated β2-adrenergic receptor recycling Proceedings of the National Academy of Sciences of the United States of America. 101: 7082-7087. PMID 15105445 DOI: 10.1073/Pnas.0308335101  0.428
2004 Gregory KN, Hahn H, Haghighi K, Marreez Y, Odley A, Dorn GW, Kranias EG. Increased particulate partitioning of PKCε reverses susceptibility of phospholamban knockout hearts to ischemic injury Journal of Molecular and Cellular Cardiology. 36: 313-318. PMID 14871559 DOI: 10.1016/J.Yjmcc.2003.12.001  0.307
2003 Hayakawa Y, Chandra M, Miao W, Shirani J, Brown JH, Dorn GW, Armstrong RC, Kitsis RN. Inhibition of Cardiac Myocyte Apoptosis Improves Cardiac Function and Abolishes Mortality in the Peripartum Cardiomyopathy of Gαq Transgenic Mice Circulation. 108: 3036-3041. PMID 14638549 DOI: 10.1161/01.Cir.0000101920.72665.58  0.419
2003 Hahn HS, Marreez Y, Odley A, Sterbling A, Yussman MG, Hilty KC, Bodi I, Liggett SB, Schwartz A, Dorn GW. Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy. Circulation Research. 93: 1111-9. PMID 14605019 DOI: 10.1161/01.Res.0000105087.79373.17  0.328
2003 Dorn GW, Robbins J, Sugden PH. Phenotyping hypertrophy: eschew obfuscation. Circulation Research. 92: 1171-5. PMID 12805233 DOI: 10.1161/01.Res.0000077012.11088.Bc  0.385
2003 Haghighi K, Kolokathis F, Pater L, Lynch RA, Asahi M, Gramolini AO, Fan GC, Tsiapras D, Hahn HS, Adamopoulos S, Liggett SB, Dorn GW, MacLennan DH, Kremastinos DT, Kranias EG. Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. The Journal of Clinical Investigation. 111: 869-76. PMID 12639993 DOI: 10.1172/Jci17892  0.403
2003 Song Q, Schmidt AG, Hahn HS, Carr AN, Frank B, Pater L, Gerst M, Young K, Hoit BD, McConnell BK, Haghighi K, Seidman CE, Seidman JG, Dorn GW, Kranias EG. Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy. The Journal of Clinical Investigation. 111: 859-67. PMID 12639992 DOI: 10.1172/Jci16738  0.316
2003 Gregory KN, Hahn H, Haghighi K, Marreez Y, Odley A, Kranias EG, Dorn GW. Perpetual preconditioning by PKCε reverses susceptibility of phospholamban deficient hearts to ischemic injury Journal of Cardiac Failure. 9: S14. DOI: 10.1016/S1071-9164(03)00269-0  0.313
2002 Hahn HS, Yussman MG, Toyokawa T, Marreez Y, Barrett TJ, Hilty KC, Osinska H, Robbins J, Dorn GW. Ischemic protection and myofibrillar cardiomyopathy: Dose-dependent effects of in vivo δPKC inhibition Circulation Research. 91: 741-748. PMID 12386152 DOI: 10.1161/01.Res.0000037091.64492.69  0.431
2002 Yussman MG, Toyokawa T, Odley A, Lynch RA, Wu G, Colbert MC, Aronow BJ, Lorenz JN, Dorn GW. Mitochondrial death protein Nix is induced in cardiac hypertrophy and triggers apoptotic cardiomyopathy. Nature Medicine. 8: 725-30. PMID 12053174 DOI: 10.1038/nm719  0.307
2001 Wu G, Yussman MG, Barrett TJ, Hahn HS, Osinska H, Hilliard GM, Wang X, Toyokawa T, Yatani A, Lynch RA, Robbins J, Dorn GW. Increased myocardial Rab GTPase expression: A consequence and cause of cardiomyopathy Circulation Research. 89: 1130-1137. PMID 11739277 DOI: 10.1161/HH2401.100427  0.327
2001 Wang X, Osinska H, Dorn GW, Nieman M, Lorenz JN, Gerdes AM, Witt S, Kimball T, Gulick J, Robbins J. Mouse model of desmin-related cardiomyopathy. Circulation. 103: 2402-7. PMID 11352891 DOI: 10.1161/01.Cir.103.19.2402  0.316
2001 Molkentin JD, Dorn GW. Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annual Review of Physiology. 63: 391-426. PMID 11181961 DOI: 10.1146/Annurev.Physiol.63.1.391  0.36
2000 Mochly-Rosen D, Wu G, Hahn H, Osinska H, Liron T, Lorenz JN, Yatani A, Robbins J, Dorn GW. Cardiotrophic effects of protein kinase C epsilon: analysis by in vivo modulation of PKCepsilon translocation. Circulation Research. 86: 1173-9. PMID 10850970 DOI: 10.1161/01.Res.86.11.1173  0.399
2000 Liggett SB, Tepe NM, Lorenz JN, Canning AM, Jantz TD, Mitarai S, Yatani A, Dorn GW. Early and delayed consequences of β2-adrenergic receptor overexpression in mouse hearts: Critical role for expression level Circulation. 101: 1707-1714. PMID 10758054 DOI: 10.1161/01.Cir.101.14.1707  0.415
2000 De Windt LJ, Lim HW, Taigen T, Wencker D, Condorelli G, Dorn GW, Kitsis RN, Molkentin JD. Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo. An apoptosis-independent model of dilated heart failure Circulation Research. 86: 255-263. PMID 10679475 DOI: 10.1161/01.Res.86.3.255  0.324
1999 Tepe NM, Lorenz JN, Yatani A, Dash R, Kranias EG, Dorn GW, Liggett SB. Altering the receptor-effector ratio by transgenic overexpression of type V adenylyl cyclase: enhanced basal catalytic activity and function without increased cardiomyocyte beta-adrenergic signalling. Biochemistry. 38: 16706-13. PMID 10600134 DOI: 10.1021/Bi991619K  0.387
1999 Sah VP, Minamisawa S, Tam SP, Wu TH, Dorn GW, Ross J, Chien KR, Brown JH. Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure. The Journal of Clinical Investigation. 103: 1627-34. PMID 10377168 DOI: 10.1172/Jci6842  0.411
1999 Dorn GW, Tepe NM, Lorenz JN, Koch WJ, Liggett SB. Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 6400-5. PMID 10339599 DOI: 10.1073/Pnas.96.11.6400  0.419
1998 Adams JW, Sakata Y, Davis MG, Sah VP, Wang Y, Liggett SB, Chien KR, Brown JH, Dorn GW. Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proceedings of the National Academy of Sciences of the United States of America. 95: 10140-5. PMID 9707614 DOI: 10.1073/Pnas.95.17.10140  0.444
1998 Davis MG, Williams M, Albright ST, Canning AM, Oliver BG, Dorn GW. Protein kinase c signaling in Gαq overexpressing mouse hearts Journal of Cardiac Failure. 4: 20. DOI: 10.1016/S1071-9164(98)90073-2  0.343
1997 D'Angelo DD, Sakata Y, Lorenz JN, Boivin GP, Walsh RA, Liggett SB, Dorn GW. Transgenic Galphaq overexpression induces cardiac contractile failure in mice. Proceedings of the National Academy of Sciences of the United States of America. 94: 8121-6. PMID 9223325 DOI: 10.1073/Pnas.94.15.8121  0.339
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