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George Chaconas - Publications

Affiliations: 
Microbiology, Immunology, and Infectious Diseases University of Calgary, Calgary, Alberta, Canada 
Area:
Microbiology, Molecular Biology, Genetics
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55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Castellanos M, Verhey TB, Goldstein M, Chaconas G. The Putative Endonuclease Activity of MutL Is Required for the Segmental Gene Conversion Events That Drive Antigenic Variation of the Lyme Disease Spirochete. Frontiers in Microbiology. 13: 888494. PMID 35663861 DOI: 10.3389/fmicb.2022.888494  0.343
2020 Lin YP, Tan X, Caine JA, Castellanos M, Chaconas G, Coburn J, Leong JM. Strain-specific joint invasion and colonization by Lyme disease spirochetes is promoted by outer surface protein C. Plos Pathogens. 16: e1008516. PMID 32413091 DOI: 10.1371/Journal.Ppat.1008516  0.353
2019 Chaconas G, Castellanos M, Verhey TB. Changing of the guard: How the Lyme disease spirochete subverts the host immune response. The Journal of Biological Chemistry. PMID 31753921 DOI: 10.1074/Jbc.Rev119.008583  0.406
2018 Verhey TB, Castellanos M, Chaconas G. Antigenic variation in the Lyme spirochete: detailed functional assessment of recombinational switching at vlsE in the JD1 strain of Borrelia burgdorferi. Molecular Microbiology. PMID 30580501 DOI: 10.1111/Mmi.14189  0.37
2018 Castellanos M, Verhey TB, Chaconas G. A Borrelia burgdorferi mini-vls system that undergoes antigenic switching in mice: investigation of the role of plasmid topology and the long inverted repeat. Molecular Microbiology. PMID 29995993 DOI: 10.1111/Mmi.14071  0.396
2018 Verhey TB, Castellanos M, Chaconas G. Antigenic Variation in the Lyme Spirochete: Insights into Recombinational Switching with a Suggested Role for Error-Prone Repair. Cell Reports. 23: 2595-2605. PMID 29847791 DOI: 10.1016/J.Celrep.2018.04.117  0.37
2017 Verhey TB, Castellanos M, Chaconas G. Analysis of recombinational switching at the antigenic variation locus of the Lyme spirochete using a novel PacBio sequencing pipeline. Molecular Microbiology. PMID 29105221 DOI: 10.1111/Mmi.13873  0.325
2015 Kumar D, Ristow LC, Shi M, Mukherjee P, Caine JA, Lee WY, Kubes P, Coburn J, Chaconas G. Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein. Plos Pathogens. 11: e1005333. PMID 26684456 DOI: 10.1371/Journal.Ppat.1005333  0.385
2014 Kobryn K, Chaconas G. Hairpin Telomere Resolvases. Microbiology Spectrum. 2. PMID 26104454 DOI: 10.1128/Microbiolspec.Mdna3-0023-2014  0.387
2014 Lee WY, Sanz MJ, Wong CH, Hardy PO, Salman-Dilgimen A, Moriarty TJ, Chaconas G, Marques A, Krawetz R, Mody CH, Kubes P. Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia. Proceedings of the National Academy of Sciences of the United States of America. 111: 13936-41. PMID 25205813 DOI: 10.1073/Pnas.1404769111  0.539
2014 Bandy NJ, Salman-Dilgimen A, Chaconas G. Construction and characterization of a Borrelia burgdorferi strain with conditional expression of the essential telomere resolvase, ResT. Journal of Bacteriology. 196: 2396-404. PMID 24748617 DOI: 10.1128/Jb.01435-13  0.408
2013 Salman-Dilgimen A, Hardy PO, Radolf JD, Caimano MJ, Chaconas G. HrpA, an RNA helicase involved in RNA processing, is required for mouse infectivity and tick transmission of the Lyme disease spirochete. Plos Pathogens. 9: e1003841. PMID 24367266 DOI: 10.1371/Journal.Ppat.1003841  0.585
2013 Coburn J, Leong J, Chaconas G. Illuminating the roles of the Borrelia burgdorferi adhesins. Trends in Microbiology. 21: 372-9. PMID 23876218 DOI: 10.1016/J.Tim.2013.06.005  0.369
2013 Chaconas G, Norris SJ. Peaceful coexistence amongst Borrelia plasmids: getting by with a little help from their friends? Plasmid. 70: 161-7. PMID 23727020 DOI: 10.1016/J.Plasmid.2013.05.002  0.4
2013 Hardy PO, Chaconas G. The nucleotide excision repair system of Borrelia burgdorferi is the sole pathway involved in repair of DNA damage by UV light. Journal of Bacteriology. 195: 2220-31. PMID 23475971 DOI: 10.1128/Jb.00043-13  0.588
2013 Walia R, Chaconas G. Suggested role for G4 DNA in recombinational switching at the antigenic variation locus of the Lyme disease spirochete. Plos One. 8: e57792. PMID 23469068 DOI: 10.1371/Journal.Pone.0057792  0.449
2012 Lin T, Gao L, Zhang C, Odeh E, Jacobs MB, Coutte L, Chaconas G, Philipp MT, Norris SJ. Analysis of an ordered, comprehensive STM mutant library in infectious Borrelia burgdorferi: insights into the genes required for mouse infectivity. Plos One. 7: e47532. PMID 23133514 DOI: 10.1371/Journal.Pone.0047532  0.423
2012 Moriarty TJ, Shi M, Lin YP, Ebady R, Zhou H, Odisho T, Hardy PO, Salman-Dilgimen A, Wu J, Weening EH, Skare JT, Kubes P, Leong J, Chaconas G. Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules. Molecular Microbiology. 86: 1116-31. PMID 23095033 DOI: 10.1111/Mmi.12045  0.571
2012 Chaconas G. CSM murray award lecture - functional studies of the Lyme disease spirochete - from molecules to mice. Canadian Journal of Microbiology. 58: 236-48. PMID 22339274 DOI: 10.1139/W11-143  0.463
2011 Salman-Dilgimen A, Hardy PO, Dresser AR, Chaconas G. HrpA, a DEAH-box RNA helicase, is involved in global gene regulation in the Lyme disease spirochete. Plos One. 6: e22168. PMID 21814569 DOI: 10.1371/Journal.Pone.0022168  0.6
2010 Chaconas G, Craig N, Curcio MJ, Deininger P, Feschotte C, Levin H, Rice PA, Voytas DF. Meeting report for mobile DNA 2010. Mobile Dna. 1: 20. PMID 20735816 DOI: 10.1186/1759-8753-1-20  0.313
2010 Chaconas G, Kobryn K. Structure, function, and evolution of linear replicons in Borrelia. Annual Review of Microbiology. 64: 185-202. PMID 20536352 DOI: 10.1146/Annurev.Micro.112408.134037  0.416
2010 Lee WY, Moriarty TJ, Wong CH, Zhou H, Strieter RM, van Rooijen N, Chaconas G, Kubes P. An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells. Nature Immunology. 11: 295-302. PMID 20228796 DOI: 10.1038/Ni.1855  0.302
2009 Dresser AR, Hardy PO, Chaconas G. Investigation of the genes involved in antigenic switching at the vlsE locus in Borrelia burgdorferi: an essential role for the RuvAB branch migrase. Plos Pathogens. 5: e1000680. PMID 19997508 DOI: 10.1371/Journal.Ppat.1000680  0.62
2009 Moriarty TJ, Chaconas G. Identification of the determinant conferring permissive substrate usage in the telomere resolvase, ResT. The Journal of Biological Chemistry. 284: 23293-301. PMID 19561077 DOI: 10.1074/Jbc.M109.023549  0.398
2009 Tourand Y, Deneke J, Moriarty TJ, Chaconas G. Characterization and in vitro reaction properties of 19 unique hairpin telomeres from the linear plasmids of the lyme disease spirochete. The Journal of Biological Chemistry. 284: 7264-72. PMID 19122193 DOI: 10.1074/Jbc.M808918200  0.405
2008 Norman MU, Moriarty TJ, Dresser AR, Millen B, Kubes P, Chaconas G. Molecular mechanisms involved in vascular interactions of the Lyme disease pathogen in a living host. Plos Pathogens. 4: e1000169. PMID 18833295 DOI: 10.1371/Journal.Ppat.1000169  0.375
2008 Moriarty TJ, Norman MU, Colarusso P, Bankhead T, Kubes P, Chaconas G. Real-time high resolution 3D imaging of the lyme disease spirochete adhering to and escaping from the vasculature of a living host. Plos Pathogens. 4: e1000090. PMID 18566656 DOI: 10.1371/Journal.Ppat.1000090  0.329
2008 Deneke J, Chaconas G. Purification and properties of the plasmid maintenance proteins from the Borrelia burgdorferi linear plasmid lp17. Journal of Bacteriology. 190: 3992-4000. PMID 18375548 DOI: 10.1128/Jb.00057-08  0.435
2007 Bankhead T, Chaconas G. The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens. Molecular Microbiology. 65: 1547-58. PMID 17714442 DOI: 10.1111/J.1365-2958.2007.05895.X  0.374
2007 Tourand Y, Lee L, Chaconas G. Telomere resolution by Borrelia burgdorferi ResT through the collaborative efforts of tethered DNA binding domains. Molecular Microbiology. 64: 580-90. PMID 17462009 DOI: 10.1111/J.1365-2958.2007.05691.X  0.378
2007 Beaurepaire C, Chaconas G. Topology-dependent transcription in linear and circular plasmids of the segmented genome of Borrelia burgdorferi. Molecular Microbiology. 63: 443-53. PMID 17241200 DOI: 10.1111/J.1365-2958.2006.05533.X  0.426
2006 Bankhead T, Kobryn K, Chaconas G. Unexpected twist: harnessing the energy in positive supercoils to control telomere resolution. Molecular Microbiology. 62: 895-905. PMID 16999829 DOI: 10.1111/J.1365-2958.2006.05423.X  0.39
2006 Tourand Y, Bankhead T, Wilson SL, Putteet-Driver AD, Barbour AG, Byram R, Rosa PA, Chaconas G. Differential telomere processing by Borrelia telomere resolvases in vitro but not in vivo. Journal of Bacteriology. 188: 7378-86. PMID 16936037 DOI: 10.1128/Jb.00760-06  0.438
2005 Chaconas G. Hairpin telomeres and genome plasticity in Borrelia: all mixed up in the end. Molecular Microbiology. 58: 625-35. PMID 16238614 DOI: 10.1111/J.1365-2958.2005.04872.X  0.41
2005 Beaurepaire C, Chaconas G. Mapping of essential replication functions of the linear plasmid lp17 of B. burgdorferi by targeted deletion walking. Molecular Microbiology. 57: 132-42. PMID 15948955 DOI: 10.1111/J.1365-2958.2005.04688.X  0.418
2005 Kobryn K, Burgin AB, Chaconas G. Uncoupling the chemical steps of telomere resolution by ResT. The Journal of Biological Chemistry. 280: 26788-95. PMID 15917226 DOI: 10.1074/Jbc.M504530200  0.343
2005 Kobryn K, Chaconas G. Fusion of hairpin telomeres by the B. burgdorferi telomere resolvase ResT implications for shaping a genome in flux. Molecular Cell. 17: 783-91. PMID 15780935 DOI: 10.1016/J.Molcel.2005.02.025  0.399
2004 Deneke J, Burgin AB, Wilson SL, Chaconas G. Catalytic residues of the telomere resolvase ResT: a pattern similar to, but distinct from, tyrosine recombinases and type IB topoisomerases. The Journal of Biological Chemistry. 279: 53699-706. PMID 15471873 DOI: 10.1074/Jbc.M409001200  0.393
2004 Bankhead T, Chaconas G. Mixing active-site components: a recipe for the unique enzymatic activity of a telomere resolvase. Proceedings of the National Academy of Sciences of the United States of America. 101: 13768-73. PMID 15365172 DOI: 10.1073/Pnas.0405762101  0.412
2003 Coros CJ, Sekino Y, Baker TA, Chaconas G. Effect of mutations in the C-terminal domain of Mu B on DNA binding and interactions with Mu A transposase. The Journal of Biological Chemistry. 278: 31210-7. PMID 12791691 DOI: 10.1074/Jbc.M303693200  0.385
2003 Tourand Y, Kobryn K, Chaconas G. Sequence-specific recognition but position-dependent cleavage of two distinct telomeres by the Borrelia burgdorferi telomere resolvase, ResT. Molecular Microbiology. 48: 901-11. PMID 12753185 DOI: 10.1046/j.1365-2958.2003.03485.x  0.328
2003 Stewart PE, Chaconas G, Rosa P. Conservation of plasmid maintenance functions between linear and circular plasmids in Borrelia burgdorferi. Journal of Bacteriology. 185: 3202-9. PMID 12730180 DOI: 10.1128/Jb.185.10.3202-3209.2003  0.412
2002 Kobryn K, Chaconas G. ResT, a telomere resolvase encoded by the Lyme disease spirochete. Molecular Cell. 9: 195-201. PMID 11804598 DOI: 10.1016/S1097-2765(01)00433-6  0.347
2001 Kobryn K, Chaconas G. The circle is broken: Telomere resolution in linear replicons Current Opinion in Microbiology. 4: 558-564. PMID 11587933 DOI: 10.1016/S1369-5274(00)00251-4  0.305
2001 Chaconas G, Stewart PE, Tilly K, Bono JL, Rosa P. Telomere resolution in the Lyme disease spirochete Embo Journal. 20: 3229-3237. PMID 11406599 DOI: 10.1093/emboj/20.12.3229  0.33
2000 Kobryn K, Naigamwalla DZ, Chaconas G. Site-specific DNA binding and bending by the Borrelia burgdorferi Hbb protein Molecular Microbiology. 37: 145-155. PMID 10931312 DOI: 10.1046/J.1365-2958.2000.01981.X  0.41
1999 Chaconas G. Studies on a 'jumping gene machine': Higher-order nucleoprotein complexes in Mu DNA transposition Biochemistry and Cell Biology. 77: 487-491. PMID 10668626  0.304
1998 Millner A, Chaconas G. Disruption of target DNA binding in Mu DNA transposition by alteration of position 99 in the Mu B protein. Journal of Molecular Biology. 275: 233-43. PMID 9466906 DOI: 10.1006/jmbi.1997.1446  0.303
1992 Wu Z, Chaconas G. Flanking host sequences can exert an inhibitory effect on the cleavage step of the in vitro Mu DNA strand transfer reaction Journal of Biological Chemistry. 267: 9552-9558. PMID 1315758  0.303
1985 Harshey RM, Getzoff ED, Baldwin DL, Miller JL, Chaconas G. Primary structure of phage Mu transposase: Homology to Mu repressor Proceedings of the National Academy of Sciences of the United States of America. 82: 7676-7680. PMID 2999776 DOI: 10.1073/Pnas.82.22.7676  0.389
1985 Chaconas G, Giddens EB, Miller JL, Gloor G. A truncated form of the bacteriophage Mu B protein promotes conservative integration, but not replicative Transposition, of Mu DNA Cell. 41: 857-865. PMID 2988792 DOI: 10.1016/S0092-8674(85)80066-0  0.325
1980 Chaconas G, van de Sande JH. [10] 5′-32P labeling of RNA and DNA restriction fragments Methods in Enzymology. 65: 75-85. PMID 6154877 DOI: 10.1016/S0076-6879(80)65012-5  0.368
1979 Loucks E, Chaconas G, Blakesley RW, Wells RD, van de Sande JH. Antibiotic induced ekctrophoretic mobility shifts of DNA restriction fragments Nucleic Acids Research. 6: 1869-1879. PMID 450716 DOI: 10.1093/Nar/6.5.1869  0.349
1975 Chaconas G, van de Sande JH, Church RB. End group labelling of RNA and double stranded DNA by phosphate exchange catalyzed by bacteriophage T4 induced polynucleotide kinase Biochemical and Biophysical Research Communications. 66: 962-969. PMID 170940 DOI: 10.1016/0006-291X(75)90734-2  0.353
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