| Year |
Citation |
Score |
| 2021 |
Kakuda N, Takami M, Okochi M, Kasuga K, Ihara Y, Ikeuchi T. Switched Aβ43 generation in familial Alzheimer's disease with presenilin 1 mutation. Translational Psychiatry. 11: 558. PMID 34728605 DOI: 10.1038/s41398-021-01684-1 |
0.32 |
|
| 2020 |
Kakuda N, Yamaguchi H, Akazawa K, Hata S, Suzuki T, Hatsuta H, Murayama S, Funamoto S, Ihara Y. γ-Secretase activity is associated with Braak Senile Plaque stages. The American Journal of Pathology. PMID 32201261 DOI: 10.1016/J.Ajpath.2020.02.009 |
0.424 |
|
| 2019 |
Kubo A, Ueda S, Yamane A, Wada-Kakuda S, Narita M, Matsuyama M, Nomori A, Takashima A, Kato T, Onodera O, Goto M, Ito M, Tomiyama T, Mori H, Murayama S, ... Ihara Y, et al. Ectopic expression induces abnormal somatodendritic distribution of tau in the mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31235644 DOI: 10.1523/JNEUROSCI.2845-18.2019 |
0.719 |
|
| 2019 |
Ikegawa M, Nirasawa T, Kakuda N, Miyasaka T, Kuzuhara Y, Murayama S, Ihara Y. Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry. Journal of Visualized Experiments : Jove. PMID 30907869 DOI: 10.3791/57645 |
0.428 |
|
| 2018 |
Kubo A, Misonou H, Matsuyama M, Nomori A, Wada-Kakuda S, Takashima A, Kawata M, Murayama S, Ihara Y, Miyasaka T. Distribution of endogenous normal tau in the mouse brain. The Journal of Comparative Neurology. PMID 30408165 DOI: 10.1002/cne.24577 |
0.718 |
|
| 2018 |
Miyasaka T, Shinzaki Y, Yoshimura S, Yoshina S, Kage-Nakadai E, Mitani S, Ihara Y. Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in Models of Tauopathy. Frontiers in Neuroscience. 12: 415. PMID 29973863 DOI: 10.3389/fnins.2018.00415 |
0.444 |
|
| 2017 |
Kakuda N, Miyasaka T, Iwasaki N, Nirasawa T, Wada-Kakuda S, Takahashi-Fujigasaki J, Murayama S, Ihara Y, Ikegawa M. Distinct deposition of amyloid-β species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry. Acta Neuropathologica Communications. 5: 73. PMID 29037261 DOI: 10.1186/s40478-017-0477-x |
0.434 |
|
| 2017 |
Tagami S, Yanagida K, Kodama TS, Takami M, Mizuta N, Oyama H, Nishitomi K, Chiu YW, Okamoto T, Ikeuchi T, Sakaguchi G, Kudo T, Matsuura Y, Fukumori A, Takeda M, ... Ihara Y, et al. Semagacestat Is a Pseudo-Inhibitor of γ-Secretase. Cell Reports. 21: 259-273. PMID 28978478 DOI: 10.1016/j.celrep.2017.09.032 |
0.382 |
|
| 2016 |
Higashide H, Ishihara S, Nobuhara M, Ihara Y, Funamoto S. Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization. Journal of Neurochemistry. PMID 28032911 DOI: 10.1111/jnc.13942 |
0.429 |
|
| 2016 |
Miyasaka T, Xie C, Yoshimura S, Shinzaki Y, Yoshina S, Kage-Nakadai E, Mitani S, Ihara Y. Curcumin improves tau-induced neuronal dysfunction of nematodes. Neurobiology of Aging. 39: 69-81. PMID 26923403 DOI: 10.1016/j.neurobiolaging.2015.11.004 |
0.437 |
|
| 2015 |
Soeda Y, Yoshikawa M, Almeida OF, Sumioka A, Maeda S, Osada H, Kondoh Y, Saito A, Miyasaka T, Kimura T, Suzuki M, Koyama H, Yoshiike Y, Sugimoto H, Ihara Y, et al. Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups. Nature Communications. 6: 10216. PMID 26671725 DOI: 10.1038/ncomms10216 |
0.456 |
|
| 2015 |
Kokawa A, Ishihara S, Fujiwara H, Nobuhara M, Iwata M, Ihara Y, Funamoto S. The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells. Acta Neuropathologica Communications. 3: 66. PMID 26531305 DOI: 10.1186/s40478-015-0247-6 |
0.336 |
|
| 2015 |
Xie C, Soeda Y, Shinzaki Y, In Y, Tomoo K, Ihara Y, Miyasaka T. Identification of key amino acids responsible for the distinct aggregation properties of microtubule-associated protein 2 and tau. Journal of Neurochemistry. PMID 26134402 DOI: 10.1111/jnc.13228 |
0.412 |
|
| 2015 |
Shimura M, Matsushita Y, Ikezaki K, Ichiyanagi K, Miyasaka T, Hiroshi S, Ihara Y, Sasaki YC. Anomalous Stiffness Changes of Tau Protein in X-ray Single Molecule Observations Biophysical Journal. 108: 62a. DOI: 10.1016/j.bpj.2014.11.370 |
0.387 |
|
| 2014 |
Miyashita A, Hatsuta H, Kikuchi M, Nakaya A, Saito Y, Tsukie T, Hara N, Ogishima S, Kitamura N, Akazawa K, Kakita A, Takahashi H, Murayama S, Ihara Y, Ikeuchi T, et al. Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease. Translational Psychiatry. 4: e396. PMID 26126179 DOI: 10.1038/tp.2014.35 |
0.407 |
|
| 2014 |
Saito Y, Miyasaka T, Hatsuta H, Takahashi-Niki K, Hayashi K, Mita Y, Kusano-Arai O, Iwanari H, Ariga H, Hamakubo T, Yoshida Y, Niki E, Murayama S, Ihara Y, Noguchi N. Immunostaining of oxidized DJ-1 in human and mouse brains. Journal of Neuropathology and Experimental Neurology. 73: 714-28. PMID 24918637 DOI: 10.1097/NEN.0000000000000087 |
0.327 |
|
| 2014 |
Xie C, Miyasaka T, Yoshimura S, Hatsuta H, Yoshina S, Kage-Nakadai E, Mitani S, Murayama S, Ihara Y. The homologous carboxyl-terminal domains of microtubule-associated protein 2 and TAU induce neuronal dysfunction and have differential fates in the evolution of neurofibrillary tangles. Plos One. 9: e89796. PMID 24587039 DOI: 10.1371/journal.pone.0089796 |
0.396 |
|
| 2014 |
Matsumura N, Takami M, Okochi M, Wada-Kakuda S, Fujiwara H, Tagami S, Funamoto S, Ihara Y, Morishima-Kawashima M. γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment. The Journal of Biological Chemistry. 289: 5109-21. PMID 24375443 DOI: 10.1074/jbc.M113.510131 |
0.352 |
|
| 2014 |
Shimura M, Matsushita Y, Ikezaki K, Miysasaka T, Ichiyanagi K, Sekiguchi H, Ihara Y, Sasaki Y. 1P082 X-ray Single Molecule Observations of Phosphorylated Tau protein's structural fluctuations(01E. Protein : Measurement & Analysis,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)) Seibutsu Butsuri. 54: S154. DOI: 10.2142/biophys.54.S154_4 |
0.305 |
|
| 2014 |
Miyashita A, Kuwano R, Hatsuta H, Kikuchi M, Nakaya A, Saito Y, Tsukie T, Hara N, Ogishima S, Kakita A, Takahashi H, Murayama S, Ihara Y, Ikeuchi T. Genes Associated With The Progression Of Neurofibrillary Tangles In Alzheimer'S Disease Brains Alzheimers & Dementia. 10: 475. DOI: 10.1016/J.Jalz.2014.05.687 |
0.389 |
|
| 2014 |
Sasaki YC, Shimura M, Matsushita Y, Ichiyanagi K, Sekiguchi H, Miyasaka T, Ihara Y. Structural Fluctuations and Aggregations of Tau Proteins from X-Ray Single Molecule Observations Biophysical Journal. 106: 58a. DOI: 10.1016/j.bpj.2013.11.399 |
0.365 |
|
| 2013 |
Funamoto S, Sasaki T, Ishihara S, Nobuhara M, Nakano M, Watanabe-Takahashi M, Saito T, Kakuda N, Miyasaka T, Nishikawa K, Saido TC, Ihara Y. Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase. Nature Communications. 4: 2529. PMID 24108142 DOI: 10.1038/ncomms3529 |
0.313 |
|
| 2013 |
Kang MS, Baek SH, Chun YS, Moore AZ, Landman N, Berman D, Yang HO, Morishima-Kawashima M, Osawa S, Funamoto S, Ihara Y, Di Paolo G, Park JH, Chung S, Kim TW. Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3. The Journal of Biological Chemistry. 288: 20868-82. PMID 23723072 DOI: 10.1074/Jbc.M112.445734 |
0.369 |
|
| 2013 |
Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M. γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43. Cell Reports. 3: 42-51. PMID 23291095 DOI: 10.1016/j.celrep.2012.11.028 |
0.351 |
|
| 2013 |
Kakuda N, Akazawa K, Hatsuta H, Murayama S, Ihara Y. Suspected limited efficacy of γ-secretase modulators. Neurobiology of Aging. 34: 1101-4. PMID 23058852 DOI: 10.1016/j.neurobiolaging.2012.08.017 |
0.417 |
|
| 2012 |
Ihara Y, Morishima-Kawashima M, Nixon R. The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2. PMID 22908190 DOI: 10.1101/cshperspect.a006361 |
0.391 |
|
| 2012 |
Kakuda N, Shoji M, Arai H, Furukawa K, Ikeuchi T, Akazawa K, Takami M, Hatsuta H, Murayama S, Hashimoto Y, Miyajima M, Arai H, Nagashima Y, Yamaguchi H, Kuwano R, ... ... Ihara Y, et al. Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease. Embo Molecular Medicine. 4: 344-52. PMID 22354516 DOI: 10.1002/emmm.201200214 |
0.378 |
|
| 2012 |
Kuwano R, Miyashita A, Koike A, Nishida N, Tokunaga K, Yamamoto K, Ihara Y, Kim J, Pericak-Vance M, Farrer L, Schellenberg G. Genome-wide association study of Alzheimer's disease: A collaborative genetic study on Alzheimer's disease with Japan, Korea and the Alzheimer's Disease Genetics Consortium Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.2111 |
0.334 |
|
| 2011 |
Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC. Potent amyloidogenicity and pathogenicity of Aβ43. Nature Neuroscience. 14: 1023-32. PMID 21725313 DOI: 10.1038/nn.2858 |
0.395 |
|
| 2011 |
Takamura A, Kawarabayashi T, Yokoseki T, Shibata M, Morishima-Kawashima M, Saito Y, Murayama S, Ihara Y, Abe K, Shoji M, Michikawa M, Matsubara E. Dissociation of β-amyloid from lipoprotein in cerebrospinal fluid from Alzheimer's disease accelerates β-amyloid-42 assembly. Journal of Neuroscience Research. 89: 815-21. PMID 21394760 DOI: 10.1002/Jnr.22615 |
0.409 |
|
| 2011 |
Kuwano R, Miyashita A, Koike A, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Ihara Y. Genome-wide association study of late-onset Alzheimer's disease in Japanese Neuroscience Research. 71: e290. DOI: 10.1016/j.neures.2011.07.1266 |
0.319 |
|
| 2010 |
Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, et al. The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel. Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society. 10: 117-23. PMID 20860566 DOI: 10.1111/j.1479-8301.2010.00330.x |
0.342 |
|
| 2010 |
Miyasaka T, Yoshimura S, Saka A, Shinzaki Y, Yoshina S, Kage-Nakadai E, Mitani S, Ihara Y. P4-026: Curcumin Improves Tau-mediated Neuronal Dysfunction in Nematode Alzheimer's & Dementia. 6: e27-e28. DOI: 10.1016/j.jalz.2010.08.086 |
0.307 |
|
| 2010 |
Miyashita A, Saito Y, Hatsuta H, Tsukie T, Kakita A, Iijima R, Ogishima S, Tanaka H, Takahashi H, Murayama S, Ihara Y, Kuwano R. P1-080: Gene expression profiling of postmortem brain tissues with Alzheimer's disease Alzheimer's & Dementia. 6: S197-S197. DOI: 10.1016/J.Jalz.2010.05.628 |
0.34 |
|
| 2009 |
Takami M, Nagashima Y, Sano Y, Ishihara S, Morishima-Kawashima M, Funamoto S, Ihara Y. gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 13042-52. PMID 19828817 DOI: 10.1523/JNEUROSCI.2362-09.2009 |
0.401 |
|
| 2008 |
Osawa S, Funamoto S, Nobuhara M, Wada-Kakuda S, Shimojo M, Yagishita S, Ihara Y. Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states. The Journal of Biological Chemistry. 283: 19283-92. PMID 18480063 DOI: 10.1074/jbc.M705954200 |
0.33 |
|
| 2008 |
Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A. Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta. The Journal of Biological Chemistry. 283: 16488-96. PMID 18430735 DOI: 10.1074/Jbc.M801279200 |
0.43 |
|
| 2008 |
Yagishita S, Morishima-Kawashima M, Ishiura S, Ihara Y. Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains. The Journal of Biological Chemistry. 283: 733-8. PMID 18024430 DOI: 10.1074/jbc.M707103200 |
0.408 |
|
| 2008 |
Miyashita A, Saito Y, Kakita A, Ogishima S, Tanaka H, Takahashi H, Murayama S, Ihara Y, Kuwano R. P3-243: Gene expression profiling of postmortem brain tissues affected by Alzheimer's disease Alzheimer's & Dementia. 4: T592-T592. DOI: 10.1016/J.Jalz.2008.05.1810 |
0.341 |
|
| 2007 |
Ihara Y. [Overview on Alzheimer's disease]. Rinshå Shinkeigaku = Clinical Neurology. 47: 902-4. PMID 18210830 |
0.304 |
|
| 2007 |
Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS. Active gamma-secretase complexes contain only one of each component. The Journal of Biological Chemistry. 282: 33985-93. PMID 17911105 DOI: 10.1074/Jbc.M705248200 |
0.366 |
|
| 2007 |
Morishima-Kawashima M, Han X, Tanimura Y, Hamanaka H, Kobayashi M, Sakurai T, Yokoyama M, Wada K, Nukina N, Fujita SC, Ihara Y. Effects of human apolipoprotein E isoforms on the amyloid beta-protein concentration and lipid composition in brain low-density membrane domains. Journal of Neurochemistry. 101: 949-58. PMID 17472586 DOI: 10.1111/J.1471-4159.2006.04400.X |
0.41 |
|
| 2006 |
Ihara Y. Neurofibrillary tangles/paired helical filaments (1981-83). Journal of Alzheimer's Disease : Jad. 9: 209-17. PMID 16914860 DOI: 10.3233/Jad-2006-9S324 |
0.317 |
|
| 2006 |
Iwatsubo T, Ihara Y, Kanazawa I. Alzheimer disease research in Japan: public funding. Nature Medicine. 12: 778-9. PMID 16829946 DOI: 10.1038/nm0706-778 |
0.477 |
|
| 2006 |
Kuwano R, Miyashita A, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Tsukie T, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, et al. Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. Human Molecular Genetics. 15: 2170-82. PMID 16740596 DOI: 10.1093/hmg/ddl142 |
0.333 |
|
| 2006 |
Kakuda N, Funamoto S, Yagishita S, Takami M, Osawa S, Dohmae N, Ihara Y. Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. The Journal of Biological Chemistry. 281: 14776-86. PMID 16595682 DOI: 10.1074/jbc.M513453200 |
0.425 |
|
| 2006 |
Yagishita S, Morishima-Kawashima M, Tanimura Y, Ishiura S, Ihara Y. DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase. Biochemistry. 45: 3952-60. PMID 16548522 DOI: 10.1021/bi0521846 |
0.416 |
|
| 2006 |
Funamoto S, Kakuda N, Yagishita S, Takami M, Osawa S, Dohmae N, Ihara Y. P3-405: Equimolar production of Abeta and AICD from C99 by gamma-secretase Alzheimer's & Dementia. 2: S495-S495. DOI: 10.1016/j.jalz.2006.05.1676 |
0.308 |
|
| 2005 |
Miyasaka T, Ding Z, Gengyo-Ando K, Oue M, Yamaguchi H, Mitani S, Ihara Y. Progressive neurodegeneration in C. elegans model of tauopathy. Neurobiology of Disease. 20: 372-83. PMID 16242642 DOI: 10.1016/j.nbd.2005.03.017 |
0.352 |
|
| 2005 |
Miyasaka T, Watanabe A, Saito Y, Murayama S, Mann DM, Yamazaki M, Ravid R, Morishima-Kawashima M, Nagashima K, Ihara Y. Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads. Journal of Neuropathology and Experimental Neurology. 64: 665-74. PMID 16106214 DOI: 10.1097/01.Jnen.0000173890.79058.1D |
0.448 |
|
| 2005 |
Sato T, Tanimura Y, Hirotani N, Saido TC, Morishima-Kawashima M, Ihara Y. Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein. Febs Letters. 579: 2907-12. PMID 15890346 DOI: 10.1016/j.febslet.2005.04.037 |
0.425 |
|
| 2005 |
Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser P, St George-Hyslop P, et al. Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. The Journal of Biological Chemistry. 280: 19070-7. PMID 15764596 DOI: 10.1074/jbc.M501130200 |
0.389 |
|
| 2005 |
Katsuno T, Morishima-Kawashima M, Saito Y, Yamanouchi H, Ishiura S, Murayama S, Ihara Y. Independent accumulations of tau and amyloid beta-protein in the human entorhinal cortex. Neurology. 64: 687-92. PMID 15728293 DOI: 10.1212/01.Wnl.0000151958.79884.86 |
0.444 |
|
| 2005 |
Uchida Y, Ohshima T, Sasaki Y, Suzuki H, Yanai S, Yamashita N, Nakamura F, Takei K, Ihara Y, Mikoshiba K, Kolattukudy P, Honnorat J, Goshima Y. Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 10: 165-79. PMID 15676027 DOI: 10.1111/J.1365-2443.2005.00827.X |
0.342 |
|
| 2005 |
Qi-Takahara Y, Morishima-Kawashima M, Tanimura Y, Dolios G, Hirotani N, Horikoshi Y, Kametani F, Maeda M, Saido TC, Wang R, Ihara Y. Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 436-45. PMID 15647487 DOI: 10.1523/JNEUROSCI.1575-04.2005 |
0.426 |
|
| 2005 |
Ivy GO, Ihara Y, Kitani K. The protease inhibitor leupeptin induces several signs of aging in brain, retina and internal organs of young rats. Archives of Gerontology and Geriatrics. 12: 119-31. PMID 15374443 DOI: 10.1016/0167-4943(91)90023-J |
0.323 |
|
| 2005 |
Ihara Y. Research on Alzheimer's disease in Japan: a personal view on history and present status. Archives of Gerontology and Geriatrics. 19: 89-104. PMID 15374277 DOI: 10.1016/0167-4943(94)90032-9 |
0.487 |
|
| 2004 |
Funamoto S, Morishima-Kawashima M, Tanimura Y, Hirotani N, Saido TC, Ihara Y. Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42. Biochemistry. 43: 13532-40. PMID 15491160 DOI: 10.1021/bi049399k |
0.429 |
|
| 2004 |
Watanabe A, Hong WK, Dohmae N, Takio K, Morishima-Kawashima M, Ihara Y. Molecular aging of tau: disulfide-independent aggregation and non-enzymatic degradation in vitro and in vivo. Journal of Neurochemistry. 90: 1302-11. PMID 15341514 DOI: 10.1111/j.1471-4159.2004.02611.x |
0.451 |
|
| 2004 |
Oyama F, Kotliarova S, Harada A, Ito M, Miyazaki H, Ueyama Y, Hirokawa N, Nukina N, Ihara Y. Gem GTPase and tau: morphological changes induced by gem GTPase in cho cells are antagonized by tau. The Journal of Biological Chemistry. 279: 27272-7. PMID 15087445 DOI: 10.1074/Jbc.M401634200 |
0.451 |
|
| 2004 |
Watanabe N, Araki W, Chui DH, Makifuchi T, Ihara Y, Tabira T. Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1013-5. PMID 15084524 DOI: 10.1096/fj.03-1040fje |
0.468 |
|
| 2004 |
Morishima M, Qi Y, Ihara Y. P1-157 Presence of long Aβ in the lysate: an implication for the mechanism of gamma-secretase cleavage Neurobiology of Aging. 25: S140. DOI: 10.1016/S0197-4580(04)80470-6 |
0.324 |
|
| 2003 |
Wada S, Morishima-Kawashima M, Qi Y, Misono H, Shimada Y, Ohno-Iwashita Y, Ihara Y. Gamma-secretase activity is present in rafts but is not cholesterol-dependent. Biochemistry. 42: 13977-86. PMID 14636066 DOI: 10.1021/bi034904j |
0.345 |
|
| 2003 |
Kanamori T, Nishimaki K, Asoh S, Ishibashi Y, Takata I, Kuwabara T, Taira K, Yamaguchi H, Sugihara S, Yamazaki T, Ihara Y, Nakano K, Matuda S, Ohta S. Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain. The Embo Journal. 22: 2913-23. PMID 12805207 DOI: 10.1093/emboj/cdg299 |
0.31 |
|
| 2003 |
Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y. Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. The Journal of Biological Chemistry. 278: 24294-301. PMID 12707272 DOI: 10.1074/Jbc.M211161200 |
0.724 |
|
| 2003 |
Qi Y, Morishima-Kawashima M, Sato T, Mitsumori R, Ihara Y. Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells. Biochemistry. 42: 1042-52. PMID 12549925 DOI: 10.1021/bi0267590 |
0.4 |
|
| 2002 |
Morishima-Kawashima M, Ihara Y. Alzheimer's disease: beta-Amyloid protein and tau. Journal of Neuroscience Research. 70: 392-401. PMID 12391602 DOI: 10.1002/jnr.10355 |
0.492 |
|
| 2001 |
Miyasaka T, Morishima-Kawashima M, Ravid R, Kamphorst W, Nagashima K, Ihara Y. Selective deposition of mutant tau in the FTDP-17 brain affected by the P301L mutation. Journal of Neuropathology and Experimental Neurology. 60: 872-84. PMID 11556544 DOI: 10.1093/Jnen/60.9.872 |
0.434 |
|
| 2001 |
Gu Y, Misonou H, Sato T, Dohmae N, Takio K, Ihara Y. Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch. The Journal of Biological Chemistry. 276: 35235-8. PMID 11483588 DOI: 10.1074/jbc.C100357200 |
0.721 |
|
| 2001 |
Yamaguchi H, Sugihara S, Ogawa A, Oshima N, Ihara Y. Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects. Journal of Neuropathology and Experimental Neurology. 60: 731-9. PMID 11444802 DOI: 10.1093/Jnen/60.7.731 |
0.414 |
|
| 2001 |
Oshima N, Morishima-Kawashima M, Yamaguchi H, Yoshimura M, Sugihara S, Khan K, Games D, Schenk D, Ihara Y. Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain. The American Journal of Pathology. 158: 2209-18. PMID 11395399 DOI: 10.1016/S0002-9440(10)64693-7 |
0.411 |
|
| 2001 |
Ihara Y. PHF and PHF-like fibrils--cause or consequence? Neurobiology of Aging. 22: 123-6. PMID 11164285 DOI: 10.1016/S0197-4580(00)00200-1 |
0.324 |
|
| 2001 |
Miyasaka T, Morishima-Kawashima M, Ravid R, Heutink P, van Swieten JC, Nagashima K, Ihara Y. Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation. The American Journal of Pathology. 158: 373-9. PMID 11159174 DOI: 10.1016/S0002-9440(10)63979-X |
0.409 |
|
| 2000 |
Morishima-Kawashima M, Oshima N, Ogata H, Yamaguchi H, Yoshimura M, Sugihara S, Ihara Y. Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain. The American Journal of Pathology. 157: 2093-9. PMID 11106581 DOI: 10.1016/S0002-9440(10)64847-X |
0.418 |
|
| 2000 |
Saito Y, Kawai M, Inoue K, Sasaki R, Arai H, Nanba E, Kuzuhara S, Ihara Y, Kanazawa I, Murayama S. Widespread expression of alpha-synuclein and tau immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course. Journal of the Neurological Sciences. 177: 48-59. PMID 10967182 DOI: 10.1016/S0022-510X(00)00337-3 |
0.362 |
|
| 2000 |
Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Frosch MP, Ding K, Ito M, Kim TW, Tanzi RE, Oyama F, Tabira T, Ando S, Ihara Y. Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. The Journal of Biological Chemistry. 275: 27901-8. PMID 10846187 DOI: 10.1074/Jbc.M004308200 |
0.385 |
|
| 2000 |
Misonou H, Morishima-Kawashima M, Ihara Y. Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells. Biochemistry. 39: 6951-9. PMID 10841777 DOI: 10.1021/bi000169p |
0.72 |
|
| 2000 |
Gu Y, Ihara Y. Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules. The Journal of Biological Chemistry. 275: 17917-20. PMID 10770920 DOI: 10.1074/jbc.C000179200 |
0.318 |
|
| 2000 |
Gu Y, Hamajima N, Ihara Y. Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522. Biochemistry. 39: 4267-75. PMID 10757975 DOI: 10.1021/bi992323h |
0.395 |
|
| 2000 |
Ihara Y. The role of tau in Alzheimer's disease Neurobiology of Aging. 21: 210. DOI: 10.1016/S0197-4580(00)83271-6 |
0.41 |
|
| 2000 |
Saito Y, Gayer A, Hamano T, Sasaki R, Nanbe E, Nakamura K, Ihara Y, Suzuki K. Molecular pathological studies of neurofibrillary tangle-predominant form of dementia Neurobiology of Aging. 21: 264. DOI: 10.1016/S0197-4580(00)83143-7 |
0.358 |
|
| 1999 |
Funato H, Enya M, Yoshimura M, Morishima-Kawashima M, Ihara Y. Presence of sodium dodecyl sulfate-stable amyloid beta-protein dimers in the hippocampus CA1 not exhibiting neurofibrillary tangle formation. The American Journal of Pathology. 155: 23-8. PMID 10393832 DOI: 10.1016/S0002-9440(10)65094-8 |
0.44 |
|
| 1999 |
Matsumura N, Yamazaki T, Ihara Y. Stable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). The American Journal of Pathology. 154: 1649-56. PMID 10362789 DOI: 10.1016/S0002-9440(10)65420-X |
0.419 |
|
| 1999 |
Watanabe A, Takio K, Ihara Y. Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau. The Journal of Biological Chemistry. 274: 7368-78. PMID 10066801 DOI: 10.1074/jbc.274.11.7368 |
0.387 |
|
| 1999 |
Enya M, Morishima-Kawashima M, Yoshimura M, Shinkai Y, Kusui K, Khan K, Games D, Schenk D, Sugihara S, Yamaguchi H, Ihara Y. Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during aging. The American Journal of Pathology. 154: 271-9. PMID 9916941 |
0.3 |
|
| 1998 |
Oyama F, Murakami N, Ihara Y. Chloroquine myopathy suggests that tau is degraded in lysosomes: implication for the formation of paired helical filaments in Alzheimer's disease. Neuroscience Research. 31: 1-8. PMID 9704973 DOI: 10.1016/S0168-0102(98)00020-0 |
0.44 |
|
| 1998 |
Murakami N, Oyama F, Gu Y, McLennan IS, Nonaka I, Ihara Y. Accumulation of tau in autophagic vacuoles in chloroquine myopathy. Journal of Neuropathology and Experimental Neurology. 57: 664-73. PMID 9690670 DOI: 10.1097/00005072-199807000-00003 |
0.446 |
|
| 1998 |
Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, ... Ihara Y, et al. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. Journal of Neurochemistry. 71: 313-22. PMID 9648880 DOI: 10.1046/J.1471-4159.1998.71010313.X |
0.59 |
|
| 1998 |
Funato H, Yoshimura M, Kusui K, Tamaoka A, Ishikawa K, Ohkoshi N, Namekata K, Okeda R, Ihara Y. Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease. The American Journal of Pathology. 152: 1633-40. PMID 9626067 |
0.304 |
|
| 1998 |
Yamazaki T, Ihara Y. Effects of specific protease inhibitors on amyloid β-protein 42 secretion Neurobiology of Aging. 19: S77-S79. PMID 9562473 DOI: 10.1016/S0197-4580(98)00031-1 |
0.426 |
|
| 1998 |
Yanagisawa K, Ihara Y. GM1 ganglioside-bound amyloid β-protein in Alzheimer's disease brain Neurobiology of Aging. 19: S65-S67. PMID 9562471 DOI: 10.1016/S0197-4580(98)00032-3 |
0.453 |
|
| 1998 |
Davies P, Resnick J, Resnick B, Gilman S, Growdon JH, Khachaturian ZS, Radebaugh TS, Roses AD, Selkoe DJ, Trojanowski JQ, Blass JP, Gibson GE, Sheu KFR, Blennow K, Delacourte A, ... ... Ihara Y, et al. Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease' Neurobiology of Aging. 19: 109-116. PMID 9558143 DOI: 10.1016/S0197-4580(98)00022-0 |
0.64 |
|
| 1998 |
Funato H, Yoshimura M, Yamazaki T, Saido TC, Ito Y, Yokofujita J, Okeda R, Ihara Y. Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain. The American Journal of Pathology. 152: 983-92. PMID 9546359 |
0.333 |
|
| 1998 |
Yoshida H, Watanabe A, Ihara Y. Collapsin response mediator protein-2 is associated with neurofibrillary tangles in Alzheimer's disease. The Journal of Biological Chemistry. 273: 9761-8. PMID 9545313 DOI: 10.1074/jbc.273.16.9761 |
0.441 |
|
| 1998 |
Yamaguchi H, Sugihara S, Ogawa A, Saido TC, Ihara Y. Diffuse plaques associated with astroglial amyloid beta protein, possibly showing a disappearing stage of senile plaques. Acta Neuropathologica. 95: 217-22. PMID 9542585 DOI: 10.1007/s004010050790 |
0.378 |
|
| 1997 |
Yanagisawa K, McLaurin J, Michikawa M, Chakrabartty A, Ihara Y. Amyloid β-protein (Aβ) associated with lipid molecules: Immunoreactivity distinct from that of soluble Aβ Febs Letters. 420: 43-46. PMID 9450547 DOI: 10.1016/S0014-5793(97)01484-1 |
0.401 |
|
| 1997 |
Namekata K, Imagawa M, Terashi A, Ohta S, Oyama F, Ihara Y. Association of transferrin C2 allele with late-onset Alzheimer's disease Human Genetics. 101: 126-129. PMID 9402955 DOI: 10.1007/s004390050600 |
0.342 |
|
| 1997 |
Tashiro K, Hasegawa M, Ihara Y, Iwatsubo T. Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex. Neuroreport. 8: 2797-801. PMID 9295120 DOI: 10.1097/00001756-199708180-00029 |
0.525 |
|
| 1997 |
Hamano T, Yoshimura M, Yamazaki T, Shinkai Y, Yanagisawa K, Kuriyama M, Ihara Y. Amyloid β-protein (Aβ) accumulation in the leptomeninges during aging and in Alzheimer disease Journal of Neuropathology and Experimental Neurology. 56: 922-932. PMID 9258262 DOI: 10.1097/00005072-199708000-00010 |
0.411 |
|
| 1997 |
Yamazaki T, Haass C, Saido TC, Omura S, Ihara Y. Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition. Biochemistry. 36: 8377-83. PMID 9204885 DOI: 10.1021/Bi970209Y |
0.437 |
|
| 1997 |
Wild-Bode C, Yamazaki T, Capell A, Leimer U, Steiner H, Ihara Y, Haass C. Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42. The Journal of Biological Chemistry. 272: 16085-8. PMID 9195901 DOI: 10.1074/jbc.272.26.16085 |
0.396 |
|
| 1997 |
Yamazaki T, Ihara Y. Molecular pathology of Alzheimer's disease Neuropathology. 17: 263-269. DOI: 10.1111/J.1440-1789.1997.Tb00051.X |
0.369 |
|
| 1996 |
Kanemaru K, Iwatsubo T, Ihara Y. Comparable amyloid beta-protein (A beta) 42(43) and A beta 40 deposition in the aged monkey brain. Neuroscience Letters. 214: 196-8. PMID 8878117 DOI: 10.1016/0304-3940(96)12893-7 |
0.531 |
|
| 1996 |
Hasegawa M, Jakes R, Crowther RA, Lee VM, Ihara Y, Goedert M. Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein. Febs Letters. 384: 25-30. PMID 8797796 DOI: 10.1016/0014-5793(96)00271-2 |
0.42 |
|
| 1996 |
Gu Y, Oyama F, Ihara Y. Tau is widely expressed in rat tissues. Journal of Neurochemistry. 67: 1235-44. PMID 8752131 DOI: 10.1046/j.1471-4159.1996.67031235.x |
0.389 |
|
| 1996 |
Nomura Y, Yamanaka Y, Kitamura Y, Arima T, Ohnuki T, Oomura Y, Sasaki K, Nagashima K, Ihara Y. Senescence-accelerated mouse. Neurochemical studies on aging. Annals of the New York Academy of Sciences. 786: 410-8. PMID 8687038 DOI: 10.1111/J.1749-6632.1996.Tb39080.X |
0.404 |
|
| 1996 |
Iwatsubo T, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski JQ, Lee VM. Lewy bodies: purification from diffuse Lewy body disease brains. Annals of the New York Academy of Sciences. 786: 195-205. PMID 8687019 DOI: 10.1111/J.1749-6632.1996.Tb39062.X |
0.449 |
|
| 1996 |
Yanagisawa K, Asami-Odaka A, Suzuki N, Ihara Y. Fractionation of amyloid beta-protein (A beta) in Alzheimer's disease and Down's syndrome brains. Presence of membrane-bound A beta. Annals of the New York Academy of Sciences. 786: 184-94. PMID 8687018 DOI: 10.1111/J.1749-6632.1996.Tb39061.X |
0.408 |
|
| 1996 |
Mann DM, Iwatsubo T, Ihara Y, Cairns NJ, Lantos PL, Bogdanovic N, Lannfelt L, Winblad B, Maat-Schieman ML, Rossor MN. Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene. The American Journal of Pathology. 148: 1257-66. PMID 8644866 |
0.503 |
|
| 1996 |
Iwatsubo T, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski JQ, Lee VM. Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease. The American Journal of Pathology. 148: 1517-29. PMID 8623921 |
0.433 |
|
| 1996 |
Fukumoto H, Asami-Odaka A, Suzuki N, Shimada H, Ihara Y, Iwatsubo T. Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques. The American Journal of Pathology. 148: 259-65. PMID 8546214 |
0.486 |
|
| 1996 |
Yanagisawa K, Odaka A, Suzuki N, Ihara Y. GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease. Nature Medicine. 1: 1062-6. PMID 7489364 DOI: 10.1038/Nm1095-1062 |
0.423 |
|
| 1996 |
Yanagisawa K, Asami-Odaka A, Suzuki N, Ihara Y. 793 GM1 ganglioside-bound amyloid ß-protein: A possible form of preamyloid Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80795-0 |
0.389 |
|
| 1996 |
Oyama F, Gu Y, Murakami N, Nonaka I, Ihara Y. 759 Nonneural tau : Transient upregulation and subsequent accumulation of big and small tau in chloroquine myopathy Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80761-5 |
0.422 |
|
| 1996 |
Hamano T, Shinkai Y, Yanagisawa K, Yoshimura M, Yamazaki T, Kuriyama M, Ihara Y. 688 Amyloid β-protein accumulates in the leptomeninges Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80690-7 |
0.324 |
|
| 1996 |
Shinkai Y, Yoshimura M, Ito Y, Shimada H, Asami-Odaka A, Suzuki N, Yanagisawa K, Ihara Y. 687 Differential patterns of amyloid β-protein deposition in cerebral cortex and leptomeninges Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80689-0 |
0.307 |
|
| 1996 |
Fukumoto H, Asami-Odaka A, Suzuki N, Shimada H, Ihara Y, Iwatsubos T. 530 Amyloid β protein (Aβ) deposition in normal aging has the same characteristics as that in Alzheimer's disease: Predominance of Aβ42(43) and association of Aβ40 with cored plaques and microglial cells Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80532-X |
0.425 |
|
| 1996 |
Yamamoto H, Hasegawa M, Ono T, Ihara Y, Miyamoto E. 510 Dephosphorylation of fetal-tau and paired helical filaments-tau by protein phosphatases in brain Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80512-4 |
0.426 |
|
| 1996 |
Tashiro K, Hasegawa M, Ihara Y, Iwatsubo T. 507 Distribution of Phosphorylated Tau in Neonatal and Adult Rat Brains Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80509-4 |
0.486 |
|
| 1995 |
Yamamoto H, Hasegawa M, Ono T, Tashima K, Ihara Y, Miyamoto E. Dephosphorylation of fetal-tau and paired helical filaments-tau by protein phosphatases 1 and 2A and calcineurin. Journal of Biochemistry. 118: 1224-1231. PMID 8720139 DOI: 10.1093/Oxfordjournals.Jbchem.A125011 |
0.43 |
|
| 1995 |
Mann DM, Iwatsubo T, Fukumoto H, Ihara Y, Odaka A, Suzuki N. Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques. Acta Neuropathologica. 90: 472-7. PMID 8560980 DOI: 10.1007/Bf00294808 |
0.527 |
|
| 1995 |
Saido TC, Iwatsubo T, Mann DM, Shimada H, Ihara Y, Kawashima S. Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques. Neuron. 14: 457-66. PMID 7857653 DOI: 10.1016/0896-6273(95)90301-1 |
0.527 |
|
| 1995 |
Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Titani K, Ihara Y. Proline-Directed And Non-Proline-Directed Phosphorylation Of Phf-Tau Journal of Biological Chemistry. 270: 823-829. PMID 7822317 DOI: 10.1074/Jbc.270.2.823 |
0.341 |
|
| 1995 |
Murakami N, Ihara Y, Nonaka I. Chloroquine treated rat: a possible model for Alzheimer's disease. Muscle & Nerve. 18: 123-5. PMID 7799987 DOI: 10.1002/MUS.880180120 |
0.323 |
|
| 1995 |
Oyama F, Shimada H, Oyama R, Ihara Y. Apolipoprotein E genotype, Alzheimer's pathologies and related gene expression in the aged population. Molecular Brain Research. 29: 92-98. PMID 7770005 DOI: 10.1016/0169-328X(94)00233-5 |
0.423 |
|
| 1995 |
Murakami N, Ihara Y, Nonaka I. Muscle fiber degeneration in distal myopathy with rimmed vacuole formation. Acta Neuropathologica. 89: 29-34. PMID 7709728 DOI: 10.1007/BF00294256 |
0.427 |
|
| 1995 |
Iwatsubo T, Mann DM, Odaka A, Suzuki N, Ihara Y. Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome. Annals of Neurology. 37: 294-9. PMID 7695229 DOI: 10.1002/Ana.410370305 |
0.523 |
|
| 1995 |
Shinkai Y, Yoshimura M, Ito Y, Odaka A, Suzuki N, Yanagisawa K, Ihara Y. Amyloid β‐proteins 1—40 and 1—42(43) in the soluble fraction of extra‐ and intracranial blood vessels Annals of Neurology. 38: 421-428. PMID 7668828 DOI: 10.1002/Ana.410380312 |
0.403 |
|
| 1995 |
Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Watanabe A, Titani K, Ihara Y. Hyperphosphorylation of tau in PHF. Neurobiology of Aging. 16: 365-71; discussion 3. PMID 7566346 DOI: 10.1016/0197-4580(95)00027-C |
0.395 |
|
| 1995 |
Mann DM, Pickering-Brown SM, Siddons MA, Iwatsubo T, Ihara Y, Asami-Odaka A, Suzuki N. The extent of amyloid deposition in brain in patients with Down's syndrome does not depend upon the apolipoprotein E genotype. Neuroscience Letters. 196: 105-8. PMID 7501233 DOI: 10.1016/0304-3940(95)11860-Y |
0.471 |
|
| 1995 |
Mann DMA, Iwatsubo T, Fukumoto H, Ihara Y, Odaka A, Suzuki N. Microglial cells and amyloid ? protein (A?) deposition: association with A?40-containing plaques Acta Neuropathologica. 90: 472-477. DOI: 10.1007/S004010050358 |
0.544 |
|
| 1994 |
Uéda K, Fukushima H, Masliah E, Xia Y, Iwai A, Yoshimoto M, Otero DA, Kondo J, Ihara Y, Saitoh T. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 90: 11282-6. PMID 8248242 DOI: 10.1073/Pnas.90.23.11282 |
0.468 |
|
| 1994 |
Oyama F, Cairns NJ, Shimada H, Oyama R, Titani K, Ihara Y. Down's syndrome: up-regulation of beta-amyloid protein precursor and tau mRNAs and their defective coordination. Journal of Neurochemistry. 62: 1062-6. PMID 8113792 DOI: 10.1046/J.1471-4159.1994.62031062.X |
0.454 |
|
| 1994 |
Suzuki N, Iwatsubo T, Odaka A, Ishibashi Y, Kitada C, Ihara Y. High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy. The American Journal of Pathology. 145: 452-60. PMID 8053502 |
0.458 |
|
| 1994 |
Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron. 13: 45-53. PMID 8043280 DOI: 10.1016/0896-6273(94)90458-8 |
0.53 |
|
| 1994 |
Iwatsubo T, Hasegawa M, Ihara Y. Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics. Acta Neuropathologica. 88: 129-36. PMID 7985493 DOI: 10.1007/Bf00294505 |
0.572 |
|
| 1994 |
Morishima M, Ihara Y. Posttranslational modifications of tau in paired helical filaments. Dementia (Basel, Switzerland). 5: 282-8. PMID 7951685 DOI: 10.1159/000106736 |
0.437 |
|
| 1994 |
Sawa A, Oyama F, Matsushita M, Ihara Y. Molecular diversity at the carboxyl terminus of human and rat tau. Brain Research. Molecular Brain Research. 27: 111-7. PMID 7877441 DOI: 10.1016/0169-328X(94)90191-0 |
0.339 |
|
| 1993 |
Oyama F, Shimada H, Oyama R, Titani K, Ihara Y. Beta-amyloid protein precursor and tau mRNA levels versus beta-amyloid plaque and neurofibrillary tangles in the aged human brain. Journal of Neurochemistry. 60: 1658-64. PMID 8473889 DOI: 10.1111/j.1471-4159.1993.tb13388.x |
0.464 |
|
| 1993 |
Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Titani K, Ihara Y. Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments. Neuron. 10: 1151-60. PMID 8391280 DOI: 10.1016/0896-6273(93)90063-W |
0.384 |
|
| 1993 |
Yoshida H, Ihara Y. Tau in paired helical filaments is functionally distinct from fetal tau: assembly incompetence of paired helical filament-tau. Journal of Neurochemistry. 61: 1183-6. PMID 8360683 DOI: 10.1111/j.1471-4159.1993.tb03642.x |
0.4 |
|
| 1993 |
Hasegawa M, Watanabe A, Takio K, Suzuki M, Arai T, Titani K, Ihara Y. Characterization of Two Distinct Monoclonal Antibodies to Paired Helical Filaments: Further Evidence for Fetal-Type Phosphorylation of the τ in Paired Helical Filaments Journal of Neurochemistry. 60: 2068-2077. PMID 7684067 DOI: 10.1111/J.1471-4159.1993.Tb03491.X |
0.368 |
|
| 1992 |
Kanemaru K, Takio K, Miura R, Titani K, Ihara Y. Fetal-type phosphorylation of the tau in paired helical filaments. Journal of Neurochemistry. 58: 1667-75. PMID 1560225 DOI: 10.1111/j.1471-4159.1992.tb10039.x |
0.34 |
|
| 1992 |
Oyama F, Shimada H, Oyama R, Titani K, Ihara Y. A novel correlation between the levels of beta-amyloid protein precursor and tau transcripts in the aged human brain. Journal of Neurochemistry. 59: 1117-25. PMID 1494902 DOI: 10.1111/j.1471-4159.1992.tb08354.x |
0.449 |
|
| 1992 |
Yanagisawa K, Ihara Y, Miyatake T. Secretory pathway of beta/A4 amyloid protein precursor in familial Alzheimer's disease with Val717 to Ile mutation. Neuroscience Letters. 144: 43-5. PMID 1436712 DOI: 10.1016/0304-3940(92)90711-F |
0.383 |
|
| 1992 |
Watanabe N, Takio K, Hasegawa M, Arai T, Titani K, Ihara Y. Tau 2: a probe for a Ser conformation in the amino terminus of tau. Journal of Neurochemistry. 58: 960-6. PMID 1371153 DOI: 10.1111/j.1471-4159.1992.tb09349.x |
0.418 |
|
| 1992 |
Iwatsubo T, Hasegawa M, Esaki Y, Ihara Y. Lack of ubiquitin immunoreactivities at both ends of neuropil threads. Possible bidirectional growth of neuropil threads. The American Journal of Pathology. 140: 277-82. PMID 1310831 |
0.494 |
|
| 1992 |
Tsuji S, Kobayashi H, Uchida Y, Ihara Y, Miyatake T. Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease. The Embo Journal. 11: 4843-4850. DOI: 10.1002/J.1460-2075.1992.Tb05590.X |
0.388 |
|
| 1991 |
Morishima-Kawashima M, Arai T, Ogawara M, Takio K, Titani K, Saitoh T, Kosik KS, Ihara Y. A possible fetal antigen of Mr 70,000 in neurofibrillary tangles. Brain Research. 554: 316-320. PMID 1933313 DOI: 10.1016/0006-8993(91)90208-D |
0.383 |
|
| 1991 |
Oyama F, Shimada H, Oyama R, Titani K, Ihara Y. Differential Expression of β Amyloid Protein Precursor (APP) and tau mRNA in the Aged Human Brain: Individual Variability and Correlation between APP-751 and Four-Repeat tau Journal of Neuropathology and Experimental Neurology. 50: 560-578. PMID 1910077 DOI: 10.1097/00005072-199109000-00004 |
0.429 |
|
| 1991 |
Yamaguchi H, Nakazato Y, Kawarabayashi T, Ishiguro K, Ihara Y, Morimatsu M, Hirai S. Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia. Acta Neuropathologica. 81: 603-609. PMID 1882636 DOI: 10.1007/Bf00296369 |
0.384 |
|
| 1991 |
Uchida Y, Takio K, Titani K, Ihara Y, Tomonaga M. The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein. Neuron. 7: 337-47. PMID 1873033 DOI: 10.1016/0896-6273(91)90272-2 |
0.373 |
|
| 1991 |
Tokuda T, Ikeda S, Yanagisawa N, Ihara Y, Glenner GG. Re-examination of ex-boxers' brains using immunohistochemistry with antibodies to amyloid beta-protein and tau protein. Acta Neuropathologica. 82: 280-285. PMID 1759560 DOI: 10.1007/Bf00308813 |
0.478 |
|
| 1991 |
Mori H, Ihara Y. Neurofibrillary Tangles, Dystrophic IMeurites (Curly Fibers), and Abnormal Phosphorylation of Tau Brain Pathology. 1: 273-277. PMID 1669717 DOI: 10.1111/J.1750-3639.1991.Tb00670.X |
0.327 |
|
| 1991 |
Ihara Y, Hasegawa M, Morishima M, Takio K. Paired helical filaments (PHF) and abnormally phosphorylated tau Neuroscience Research Supplements. 16: VIII. DOI: 10.1016/0921-8696(91)90616-U |
0.366 |
|
| 1990 |
Kondo J, Honda T, Mori H, Hamada Y, Miura R, Ogawara M, Ihara Y. The carboxyl third of tau is tightly bound to paired helical filaments. Neuron. 1: 827-34. PMID 2483105 DOI: 10.1016/0896-6273(88)90130-4 |
0.413 |
|
| 1990 |
Hasegawa M, Arai T, Ihara Y. Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease. Neuron. 4: 909-18. PMID 2361014 DOI: 10.1016/0896-6273(90)90144-5 |
0.349 |
|
| 1990 |
Murayama S, Mori H, Ihara Y, Tomonaga M. Immunocytochemical and ultrastructural studies of Pick's disease. Annals of Neurology. 27: 394-405. PMID 2162145 DOI: 10.1002/Ana.410270407 |
0.323 |
|
| 1990 |
Murayama S, Mori H, Ihara Y, Bouldin TW, Suzuki K, Tomonaga M. Immunocytochemical and ultrastructural studies of lower motor neurons in amyotrophic lateral sclerosis. Annals of Neurology. 27: 137-48. PMID 2156479 DOI: 10.1002/Ana.410270208 |
0.304 |
|
| 1990 |
Yamaguchi H, Ishiguro K, Shoji M, Yamazaki T, Nakazato Y, Ihara Y, Hirai S. Amyloid β/A4 protein precursor is bound to neurofibrillary tangles in Alzheimer-type dementia Brain Research. 537: 318-322. PMID 1982242 DOI: 10.1016/0006-8993(90)90377-N |
0.437 |
|
| 1990 |
Ihara Y, Kondo J, Miura R, Nakagawa Y, Mori H, Honda T. Characterization of antisera to paired helical filaments and tau. Implication for the extent of tau tightly bound to paired helical filaments. Gerontology. 36: 15-24. PMID 1696559 DOI: 10.1159/000213229 |
0.399 |
|
| 1989 |
Ihara Y. What mediates between beta-amyloid and paired helical filaments? Neurobiology of Aging. 10: 573-4; discussion 58. PMID 2530464 DOI: 10.1016/0197-4580(89)90132-2 |
0.451 |
|
| 1989 |
Kanai Y, Takemura R, Oshima T, Mori H, Ihara Y, Yanagisawa M, Masaki T, Hirokawa N. Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA. The Journal of Cell Biology. 109: 1173-84. PMID 2504728 DOI: 10.1083/Jcb.109.3.1173 |
0.419 |
|
| 1989 |
Takio K, Hasegawa M, Titani K, Ihara Y. Identification of beta protein precursor in newborn rat brain. Biochemical and Biophysical Research Communications. 160: 1296-301. PMID 2499330 DOI: 10.1016/S0006-291X(89)80144-5 |
0.378 |
|
| 1989 |
Mori H, Hamada Y, Kawaguchi M, Honda T, Kondo J, Ihara Y. A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments Biochemical and Biophysical Research Communications. 159: 1221-1226. PMID 2495000 DOI: 10.1016/0006-291X(89)92240-7 |
0.437 |
|
| 1989 |
Ivy GO, Kitani K, Ihara Y. Anomalous accumulation of tau and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis? Brain Research. 498: 360-5. PMID 2477115 DOI: 10.1016/0006-8993(89)91117-7 |
0.413 |
|
| 1988 |
Kuzuhara S, Mori H, Izumiyama N, Yoshimura M, Ihara Y. Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study. Acta Neuropathologica. 75: 345-53. PMID 3364159 DOI: 10.1007/Bf00687787 |
0.382 |
|
| 1988 |
Uchida Y, Ihara Y, Tomonaga M. Alzheimer's disease brain extract stimulates the survival of cerebral cortical neurons from neonatal rats Biochemical and Biophysical Research Communications. 150: 1263-1267. PMID 3342070 DOI: 10.1016/0006-291X(88)90765-6 |
0.356 |
|
| 1988 |
Ihara Y. Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease. Brain Research. 459: 138-44. PMID 3139259 DOI: 10.1016/0006-8993(88)90293-4 |
0.394 |
|
| 1988 |
Ishiguro K, Ihara Y, Uchida T, Imahori K. A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau. Journal of Biochemistry. 104: 319-321. PMID 2467901 DOI: 10.1093/Oxfordjournals.Jbchem.A122465 |
0.405 |
|
| 1987 |
Mori H, Kondo J, Ihara Y. Ubiquitin is a component of paired helical filaments in Alzheimer's disease Science. 235: 1641-1644. PMID 3029875 DOI: 10.1126/Science.3029875 |
0.401 |
|
| 1986 |
Ihara Y, Nukina N, Miura R, Ogawara M. Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease. Journal of Biochemistry. 99: 1807-10. PMID 2427509 DOI: 10.1097/00002093-198701030-00016 |
0.414 |
|
| 1986 |
Nukina N, Ihara Y. One of the antigenic determinants of paired helical filaments is related to tau protein. Journal of Biochemistry. 99: 1541-4. PMID 2423512 DOI: 10.1093/Oxfordjournals.Jbchem.A135625 |
0.464 |
|
| 1986 |
Nukina N, Kosik K, Selkoe D, Ihara Y. TAU PROTEIN IS INTEGRATED INTO PAIRED HELICAL FILAMENTS (PHF) IN ALZHEIMERʼS DISEASE (AD) Journal of Neuropathology and Experimental Neurology. 45: 338. DOI: 10.1097/00005072-198605000-00074 |
0.563 |
|
| 1985 |
Nukina N, Ihara Y. Proteolytic fragments of Alzheimer's paired helical filaments. Journal of Biochemistry. 98: 1715-8. PMID 2419316 DOI: 10.1093/Oxfordjournals.Jbchem.A135443 |
0.311 |
|
| 1983 |
Ihara Y, Abraham C, Selkoe DJ. Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins. Nature. 304: 727-30. PMID 6350889 DOI: 10.1038/304727A0 |
0.535 |
|
| 1983 |
Selkoe D, Abraham C, Ihara Y, Pope A. 105 ANTIBODIES TO THE FAIL TO REACT WITH NEUROFILAMENTS AND OTHER NORMAL PROTEINS Journal of Neuropathology and Experimental Neurology. 42: 340. DOI: 10.1097/00005072-198305000-00112 |
0.456 |
|
| 1982 |
Selkoe DJ, Abraham C, Ihara Y. Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers. Proceedings of the National Academy of Sciences of the United States of America. 79: 6070-4. PMID 6136967 DOI: 10.1073/Pnas.79.19.6070 |
0.511 |
|
| 1982 |
Selkoe DJ, Ihara Y, Salazar FJ. Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea. Science (New York, N.Y.). 215: 1243-5. PMID 6120571 DOI: 10.1126/Science.6120571 |
0.525 |
|
| 1982 |
Selkoe DJ, Abraham C, Ihara Y. CROSSLINKING OF ALZHEIMER PAIRED HELICAL FILAMENTS Journal of Neuropathology and Experimental Neurology. 41: 354. DOI: 10.1097/00005072-198205000-00048 |
0.543 |
|
| 1979 |
Ihara Y, Fujii T, Arai T, Tanaka R, Kaziro Y. The presence of an adenosine-5'-triphosphatase dependent on 6S tubulin and calcium ions in rat brain microtubules Journal of Biochemistry. 86: 587-590. PMID 158016 DOI: 10.1093/Oxfordjournals.Jbchem.A132560 |
0.328 |
|
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