Alan McLachlan - Publications

Affiliations: 
Microbiology and Immunology University of Illinois at Chicago, Chicago, IL, United States 
Area:
Virology Biology

73 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Matrenec R, Oropeza CE, Dekoven E, Tarnow G, Maienschein-Cline M, Chau CS, Green SJ, McLachlan A. Ten-eleven translocation (Tet) methylcytosine dioxygenase-dependent viral DNA demethylation mediates hepatitis B virus (HBV) biosynthesis. Journal of Virology. e0172123. PMID 38179947 DOI: 10.1128/jvi.01721-23  0.457
2022 Tarnow G, Matrenec R, Oropeza CE, Maienschein-Cline M, McLachlan A. Distinct phenotypic spectra of hepatocellular carcinoma in liver-specific tumor suppressor-deficient hepatitis B virus transgenic mice. Virology. 574: 84-95. PMID 35961146 DOI: 10.1016/j.virol.2022.08.002  0.35
2022 Tarnow G, McLachlan A. Selective effect of β-catenin on nuclear receptor-dependent hepatitis B virus transcription and replication. Virology. 571: 52-58. PMID 35509137 DOI: 10.1016/j.virol.2022.04.006  0.51
2022 Oropeza CE, Ondracek CR, Tarnow G, Maienschein-Cline M, Green SJ, McLachlan A. Heterogeneous phenotypes of Pten-null hepatocellular carcinoma in hepatitis B virus transgenic mice parallels liver lobule zonal gene expression patterns. Virology. 566: 16-25. PMID 34844082 DOI: 10.1016/j.virol.2021.11.007  0.742
2021 Tarnow G, McLachlan A. B-Catenin Signaling Regulates the Distribution of Hepatitis B Virus Biosynthesis across the Liver Lobule. Journal of Virology. JVI0078021. PMID 34319157 DOI: 10.1128/JVI.00780-21  0.454
2020 Oropeza CE, Tarnow G, Taha TY, Shalaby RE, Hyde MV, Maienschein-Cline M, Green SJ, McLachlan A. Relative DNA methylation and demethylation efficiencies during postnatal liver development regulate hepatitis B virus biosynthesis. Journal of Virology. PMID 33361417 DOI: 10.1128/JVI.02148-20  0.45
2020 Taha TY, Anirudhan V, Limothai U, Loeb DD, Petukhov PA, McLachlan A. Modulation of hepatitis B virus pregenomic RNA stability and splicing by histone deacetylase 5 enhances viral biosynthesis. Plos Pathogens. 16: e1008802. PMID 32822428 DOI: 10.1371/Journal.Ppat.1008802  0.546
2020 Oropeza CE, Tarnow G, Sridhar A, Taha TY, Shalaby RE, McLachlan A. The Regulation of HBV Transcription and Replication. Advances in Experimental Medicine and Biology. 1179: 39-69. PMID 31741333 DOI: 10.1007/978-981-13-9151-4_3  0.603
2019 Aboukhatwa SM, Hanigan TW, Taha TY, Neerasa J, Ranjan R, El-Bastawissy EE, Elkersh MA, El-Moselhy TF, Frasor J, Mahmud N, McLachlan A, Petukhov PA. Structurally Diverse Histone Deacetylase Photoreactive Probes: Design, Synthesis, and Photolabeling Studies in Live Cells and Tissue. Chemmedchem. PMID 30921497 DOI: 10.1002/Cmdc.201900114  0.319
2018 Shalaby RE, Iram S, Oropeza CE, McLachlan A. Peroxisome proliferator-activated receptor γ coactivator family members competitively regulate hepatitis b virus biosynthesis. Virology. 526: 214-221. PMID 30419515 DOI: 10.1016/J.Virol.2018.10.027  0.637
2017 Shalaby RE, Iram S, Çakal B, Oropeza CE, McLachlan A. PGC1α TRANSCRIPTIONAL ADAPTOR FUNCTION GOVERNS HEPATITIS B VIRUS REPLICATION BY CONTROLLING HBcAg/p21 PROTEIN MEDIATED CAPSID FORMATION. Journal of Virology. PMID 28768874 DOI: 10.1128/Jvi.00790-17  0.634
2017 McFadden VC, Shalaby RE, Iram S, Oropeza CE, Landolfi JA, Lyubimov AV, Maienschein-Cline M, Green S, Kaestner KH, McLachlan A. Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation. Plos Pathogens. 13: e1006239. PMID 28235042 DOI: 10.1371/Journal.Ppat.1006239  0.595
2014 Koh KH, Pan X, Zhang W, McLachlan A, Urrutia R, Jeong H. Krüppel-like factor 9 promotes hepatic cytochrome P450 2D6 expression during pregnancy in CYP2D6-humanized mice. Molecular Pharmacology. 86: 727-35. PMID 25217496 DOI: 10.1124/Mol.114.093666  0.414
2013 Wooddell CI, Rozema DB, Hossbach M, John M, Hamilton HL, Chu Q, Hegge JO, Klein JJ, Wakefield DH, Oropeza CE, Deckert J, Roehl I, Jahn-Hofmann K, Hadwiger P, Vornlocher HP, ... McLachlan A, et al. Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 973-85. PMID 23439496 DOI: 10.1038/Mt.2013.31  0.522
2013 Reese VC, Oropeza CE, McLachlan A. Independent activation of hepatitis B virus biosynthesis by retinoids, peroxisome proliferators, and bile acids. Journal of Virology. 87: 991-7. PMID 23135717 DOI: 10.1128/Jvi.01562-12  0.575
2013 Wooddell CI, Trubetskoy V, Hagen C, Perillo-Nicholas A, Griffin JB, Hamilton H, Chu Q, McLachlan A, Rozema D, Lewis D. Sa1015 Long Duration of Effect From RNAI Therapeutic to Treat Chronic Hepatitis B Virus Infection Correlates With Persistence of the Phosphorylated Guide Strand Gastroenterology. 144: S-973. DOI: 10.1016/S0016-5085(13)63613-6  0.511
2012 Reese VC, Moore DD, McLachlan A. Limited effects of bile acids and small heterodimer partner on hepatitis B virus biosynthesis in vivo. Journal of Virology. 86: 2760-8. PMID 22171277 DOI: 10.1128/Jvi.06742-11  0.642
2012 Wooddell C, John M, Hossbach M, Deckert J, Hadwiger P, Hamilton H, Chu Q, Wakefield D, Klein J, Vornlocher H, McLachlan A, Rozema D, Lewis D. RNAi therapeutics for the treatment of chronic hepatitis B virus infection International Journal of Infectious Diseases. 16: e48. DOI: 10.1016/J.Ijid.2012.05.120  0.467
2011 Ondracek CR, McLachlan A. Role of peroxisome proliferator-activated receptor gamma coactivator 1alpha in AKT/PKB-mediated inhibition of hepatitis B virus biosynthesis. Journal of Virology. 85: 11891-900. PMID 21880746 DOI: 10.1128/Jvi.00832-11  0.801
2011 Reese V, Ondracek C, Rushing C, Li L, Oropeza CE, McLachlan A. Multiple nuclear receptors may regulate hepatitis B virus biosynthesis during development. The International Journal of Biochemistry & Cell Biology. 43: 230-7. PMID 19941970 DOI: 10.1016/J.Biocel.2009.11.016  0.793
2009 Ondracek CR, Rushing CN, Reese VC, Oropeza CE, McLachlan A. Peroxisome proliferator-activated receptor gamma Coactivator 1alpha and small heterodimer partner differentially regulate nuclear receptor-dependent hepatitis B virus biosynthesis. Journal of Virology. 83: 12535-44. PMID 19793822 DOI: 10.1128/Jvi.01623-09  0.795
2009 Ondracek CR, Reese VC, Rushing CN, Oropeza CE, McLachlan A. Distinct regulation of hepatitis B virus biosynthesis by peroxisome proliferator-activated receptor gamma coactivator 1alpha and small heterodimer partner in human hepatoma cell lines. Journal of Virology. 83: 12545-51. PMID 19793803 DOI: 10.1128/Jvi.01624-09  0.792
2009 Li L, Oropeza CE, Sainz B, Uprichard SL, Gonzalez FJ, McLachlan A. Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha. Plos One. 4: e5489. PMID 19424486 DOI: 10.1371/Journal.Pone.0005489  0.615
2009 Li L, Oropeza CE, Kaestner KH, McLachlan A. Limited effects of fasting on hepatitis B virus (HBV) biosynthesis in HBV transgenic mice. Journal of Virology. 83: 1682-8. PMID 19073739 DOI: 10.1128/Jvi.02208-08  0.666
2008 Oropeza CE, Li L, McLachlan A. Differential inhibition of nuclear hormone receptor-dependent hepatitis B virus replication by the small heterodimer partner. Journal of Virology. 82: 3814-21. PMID 18234786 DOI: 10.1128/Jvi.02507-07  0.642
2008 Kallwitz ER, McLachlan A, Cotler SJ. Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease. World Journal of Gastroenterology. 14: 22-8. PMID 18176957 DOI: 10.3748/Wjg.14.22  0.431
2007 Oropeza CE, McLachlan A. Complementarity between epsilon and phi sequences in pregenomic RNA influences hepatitis B virus replication efficiency. Virology. 359: 371-81. PMID 17056086 DOI: 10.1016/J.Virol.2006.08.036  0.477
2005 Anderson AL, Banks KE, Pontoglio M, Yaniv M, McLachlan A. Alpha/beta interferon differentially modulates the clearance of cytoplasmic encapsidated replication intermediates and nuclear covalently closed circular hepatitis B virus (HBV) DNA from the livers of hepatocyte nuclear factor 1alpha-null HBV transgenic mice. Journal of Virology. 79: 11045-52. PMID 16103155 DOI: 10.1128/Jvi.79.17.11045-11052.2005  0.503
2002 Tang H, McLachlan A. A pregenomic RNA sequence adjacent to DR1 and complementary to epsilon influences hepatitis B virus replication efficiency. Virology. 303: 199-210. PMID 12482672 DOI: 10.1006/Viro.2002.1645  0.523
2002 Banks KE, Anderson AL, Tang H, Hughes DE, Costa RH, McLachlan A. Hepatocyte nuclear factor 3beta inhibits hepatitis B virus replication in vivo. Journal of Virology. 76: 12974-80. PMID 12438623 DOI: 10.1128/Jvi.76.24.12974-12980.2002  0.556
2002 Tang H, McLachlan A. Mechanisms of inhibition of nuclear hormone receptor-dependent hepatitis B virus replication by hepatocyte nuclear factor 3beta. Journal of Virology. 76: 8572-81. PMID 12163577 DOI: 10.1128/Jvi.76.17.8572-8581.2002  0.647
2002 Tang H, McLachlan A. Avian and Mammalian hepadnaviruses have distinct transcription factor requirements for viral replication. Journal of Virology. 76: 7468-72. PMID 12097559 DOI: 10.1128/Jvi.76.15.7468-7472.2002  0.651
2002 Alcantara FF, Tang H, McLachlan A. Functional characterization of the interferon regulatory element in the enhancer 1 region of the hepatitis B virus genome. Nucleic Acids Research. 30: 2068-75. PMID 11972347 DOI: 10.1093/Nar/30.9.2068  0.535
2001 Raney AK, Kline EF, Tang H, McLachlan A. Transcription and replication of a natural hepatitis B virus nucleocapsid promoter variant is regulated in vivo by peroxisome proliferators. Virology. 289: 239-51. PMID 11689047 DOI: 10.1006/Viro.2001.1169  0.668
2001 Tang H, Raney AK, McLachlan A. Replication of the wild type and a natural hepatitis B virus nucleocapsid promoter variant is differentially regulated by nuclear hormone receptors in cell culture. Journal of Virology. 75: 8937-48. PMID 11533157 DOI: 10.1128/Jvi.75.19.8937-8948.2001  0.587
2001 Raney AK, Eggers CM, Kline EF, Guidotti LG, Pontoglio M, Yaniv M, McLachlan A. Nuclear covalently closed circular viral genomic DNA in the liver of hepatocyte nuclear factor 1 alpha-null hepatitis B virus transgenic mice. Journal of Virology. 75: 2900-11. PMID 11222715 DOI: 10.1128/Jvi.75.6.2900-2911.2001  0.612
2001 Tang H, McLachlan A. Transcriptional regulation of hepatitis B virus by nuclear hormone receptors is a critical determinant of viral tropism Proceedings of the National Academy of Sciences. 98: 1841-1846. DOI: 10.1073/Pnas.98.4.1841  0.666
1999 Guidotti LG, Eggers CM, Raney AK, Chi SY, Peters JM, Gonzalez FJ, McLachlan A. In vivo regulation of hepatitis B virus replication by peroxisome proliferators. Journal of Virology. 73: 10377-86. PMID 10559356 DOI: 10.1128/Jvi.73.12.10377-10386.1999  0.581
1997 Raney AK, McLachlan A. Characterization of the hepatitis B virus major surface antigen promoter hepatocyte nuclear factor 3 binding site. The Journal of General Virology. 78: 3029-38. PMID 9367390 DOI: 10.1099/0022-1317-78-11-3029  0.555
1997 Raney AK, Johnson JL, Palmer CN, McLachlan A. Members of the nuclear receptor superfamily regulate transcription from the hepatitis B virus nucleocapsid promoter. Journal of Virology. 71: 1058-71. PMID 8995626 DOI: 10.1128/jvi.71.2.1058-1071.1997  0.567
1995 Raney AK, McLachlan A. Characterization of the hepatitis B virus large surface antigen promoter Sp1 binding site. Virology. 208: 399-404. PMID 11831727 DOI: 10.1006/Viro.1995.1167  0.466
1995 Johnson JL, Raney AK, McLachlan A. Characterization of a functional hepatocyte nuclear factor 3 binding site in the hepatitis B virus nucleocapsid promoter. Virology. 208: 147-58. PMID 11831695 DOI: 10.1006/Viro.1995.1138  0.539
1995 Johnson JL, McLachlan A. Novel clustering of Sp1 transcription factor binding sites at the transcription initiation site of the human muscle phosphofructokinase P1 promoter. Nucleic Acids Research. 22: 5085-92. PMID 7800504 DOI: 10.1093/Nar/22.23.5085  0.385
1995 Raney AK, Zhang P, McLachlan A. Regulation of transcription from the hepatitis B virus large surface antigen promoter by hepatocyte nuclear factor 3. Journal of Virology. 69: 3265-72. PMID 7745673 DOI: 10.1128/jvi.69.6.3265-3272.1995  0.477
1994 Le HB, Vaisanen PA, Johnson JL, Raney AK, McLachlan A. Regulation of transcription from the human muscle phosphofructokinase P2 promoter by the Sp1 transcription factor. Dna and Cell Biology. 13: 473-85. PMID 8024691 DOI: 10.1089/Dna.1994.13.473  0.4
1994 Zhang P, McLachlan A. Differentiation-specific transcriptional regulation of the hepatitis B virus nucleocapsid gene in human hepatoma cell lines. Virology. 202: 430-40. PMID 8009854 DOI: 10.1006/Viro.1994.1359  0.545
1994 Raney AK, Easton AJ, McLachlan A. Characterization of the minimal elements of the hepatitis B virus large surface antigen promoter. The Journal of General Virology. 75: 2671-9. PMID 7931153 DOI: 10.1099/0022-1317-75-10-2671  0.51
1993 Maruyama T, McLachlan A, Iino S, Koike K, Kurokawa K, Milich DR. The serology of chronic hepatitis B infection revisited Journal of Clinical Investigation. 91: 2586-2595. PMID 8514870 DOI: 10.1172/Jci116497  0.396
1993 Zhang P, Raney AK, McLachlan A. Characterization of functional Sp1 transcription factor binding sites in the hepatitis B virus nucleocapsid promoter. Journal of Virology. 67: 1472-81. PMID 8437225 DOI: 10.1128/Jvi.67.3.1472-1481.1993  0.476
1992 Zhang P, Raney AK, McLachlan A. Characterization of the hepatitis B virus X- and nucleocapsid gene transcriptional regulatory elements. Virology. 191: 31-41. PMID 1413508 DOI: 10.1016/0042-6822(92)90163-J  0.516
1992 Raney AK, Le HB, McLachlan A. Regulation of transcription from the hepatitis B virus major surface antigen promoter by the Sp1 transcription factor. Journal of Virology. 66: 6912-21. PMID 1331502 DOI: 10.1128/Jvi.66.12.6912-6921.1992  0.495
1991 Eckhardt SG, Milich DR, McLachlan A. Hepatitis B Virus Core Antigen Has Two Nuclear Localization Sequences In The Arginine-Rich Carboxyl Terminus Journal of Virology. 65: 575-582. PMID 1987370 DOI: 10.1128/Jvi.65.2.575-582.1991  0.41
1991 Milich DR, McLachlan A, Raney AK, Houghten R, Thornton GB, Maruyama T, Hughes JL, Jones JE. Autoantibody production in hepatitis B e antigen transgenic mice elicited with a self T-cell peptide and inhibited with nonself peptides. Proceedings of the National Academy of Sciences of the United States of America. 88: 4348-52. PMID 1827917 DOI: 10.1073/Pnas.88.10.4348  0.356
1991 Raney AK, Easton AJ, Milich DR, McLachlan A. Promoter-specific transactivation of hepatitis B virus transcription by a glutamine- and proline-rich domain of hepatocyte nuclear factor 1. Journal of Virology. 65: 5774-81. PMID 1656070 DOI: 10.1128/Jvi.65.11.5774-5781.1991  0.545
1991 Raney AK, Milich DR, McLachlan A. Complex regulation of transcription from the hepatitis B virus major surface antigen promoter in human hepatoma cell lines. Journal of Virology. 65: 4805-11. PMID 1651407 DOI: 10.1128/Jvi.65.9.4805-4811.1991  0.468
1990 Milich DR, Jones JE, Hughes JL, Price J, Raney AK, McLachlan A. Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proceedings of the National Academy of Sciences of the United States of America. 87: 6599-603. PMID 2395863 DOI: 10.1073/Pnas.87.17.6599  0.434
1990 Raney AK, Milich DR, Easton AJ, McLachlan A. Differentiation-specific transcriptional regulation of the hepatitis B virus large surface antigen gene in human hepatoma cell lines. Journal of Virology. 64: 2360-8. PMID 2157890 DOI: 10.1128/Jvi.64.5.2360-2368.1990  0.522
1989 Raney AK, Milich DR, Hughes JL, Sorge J, Chisari FV, Mondelli MU, McLachlan A. Retroviral-mediated transfer and expression of hepatitis B e antigen in human primary skin fibroblasts and Epstein-Barr virus-transformed B lymphocytes. Virology. 168: 31-9. PMID 2783354 DOI: 10.1016/0042-6822(89)90400-5  0.484
1989 Raney AK, Milich DR, McLachlan A. Characterization of hepatitis B virus major surface antigen gene transcriptional regulatory elements in differentiated hepatoma cell lines. Journal of Virology. 63: 3919-25. PMID 2548006 DOI: 10.1128/Jvi.63.9.3919-3925.1989  0.533
1988 Milich DR, McLachlan A, Thornton GB. T-cell recognition of pre-S regions of HBsAg can bypass nonresponse to the S region. Advances in Experimental Medicine and Biology. 225: 233-9. PMID 2455965 DOI: 10.1007/978-1-4684-5442-0_20  0.33
1988 Milich DR, Hughes JL, McLachlan A, Thornton GB, Moriarty A. Hepatitis B synthetic immunogen comprised of nucleocapsid T-cell sites and an envelope B-cell epitope. Proceedings of the National Academy of Sciences of the United States of America. 85: 1610-4. PMID 2449694 DOI: 10.1073/Pnas.85.5.1610  0.366
1987 McLachlan A, Milich DR, Raney AK, Riggs MG, Hughes JL, Sorge J, Chisari FV. Expression of hepatitis B virus surface and core antigens: influences of pre-S and precore sequences. Journal of Virology. 61: 683-92. PMID 3543403 DOI: 10.1128/Jvi.61.3.683-692.1987  0.446
1987 Milich DR, McLachlan A. The nucleocapsid of hepatitis B virus is both a T-cell-independent and a T-cell-dependent antigen. Science (New York, N.Y.). 234: 1398-401. PMID 3491425 DOI: 10.1126/Science.3491425  0.39
1987 Chisari FV, Filippi P, Buras J, McLachlan A, Popper H, Pinkert CA, Palmiter RD, Brinster RL. Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 84: 6909-13. PMID 3477814 DOI: 10.1073/Pnas.84.19.6909  0.503
1987 Milich DR, McLachlan A, Thornton GB, Hughes JL. Antibody production to the nucleocapsid and envelope of the hepatitis B virus primed by a single synthetic T cell site. Nature. 329: 547-9. PMID 2443856 DOI: 10.1038/329547A0  0.406
1986 Chisari FV, Filippi P, McLachlan A, Milich DR, Riggs M, Lee S, Palmiter RD, Pinkert CA, Brinster RL. Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. Journal of Virology. 60: 880-7. PMID 3783819 DOI: 10.1128/Jvi.60.3.880-887.1986  0.476
1986 McLachlan A, Lin P. A Drosophila RNA polymerase II cell-free DNA-dependent transcription system. Biochimica Et Biophysica Acta. 866: 83-8. PMID 3081030 DOI: 10.1016/0167-4781(86)90104-1  0.4
1986 McLachlan A. Drosophila forked locus. Molecular and Cellular Biology. 6: 1-6. PMID 3023816 DOI: 10.1128/Mcb.6.1.1  0.325
1986 Milich DR, McLachlan A, Chisari FV, Thornton GB. Nonoverlapping T and B cell determinants on an hepatitis B surface antigen pre-S(2) region synthetic peptide. The Journal of Experimental Medicine. 164: 532-47. PMID 2425034 DOI: 10.1084/Jem.164.2.532  0.354
1986 Milich DR, McNamara MK, McLachlan A, Thornton GB, Chisari FV. Distinct H-2-linked regulation of T-cell responses to the pre-S and S regions of the same hepatitis B surface antigen polypeptide allows circumvention of nonresponsiveness to the S region. Proceedings of the National Academy of Sciences of the United States of America. 82: 8168-72. PMID 2415982 DOI: 10.1073/Pnas.82.23.8168  0.34
1985 Chisari FV, Pinkert CA, Milich DR, Filippi P, McLachlan A, Palmiter RD, Brinster RL. A transgenic mouse model of the chronic hepatitis B surface antigen carrier state. Science (New York, N.Y.). 230: 1157-60. PMID 3865369 DOI: 10.1126/Science.3865369  0.519
1982 McLachlan A, Hardman N. Analysis of foldback sequences and repetitive sequences in cloned segments of nuclear DNA from Physarum polycephalum. Biochimica Et Biophysica Acta. 697: 89-100. PMID 6896288 DOI: 10.1016/0167-4781(82)90049-5  0.307
1979 Hardman N, Jack PL, Brown AJ, McLachlan A. Characterisation of ribosomal satellite in total nuclear DNA from Physarum polycephalum. Biochimica Et Biophysica Acta. 562: 365-76. PMID 454607 DOI: 10.1016/0005-2787(79)90101-1  0.31
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