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Andres E. Leschziner - Publications

Affiliations: 
2015- Cellular and Molecular Medicine UC San Diego Health 
Area:
structural biology
Website:
https://andres-leschziner.squarespace.com/config/
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58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Sarsam RD, Xu J, Lahiri I, Gong W, Li Q, Oh J, Zhou Z, Hou P, Chong J, Hao N, Li S, Wang D, Leschziner AE. Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair. Proceedings of the National Academy of Sciences of the United States of America. 121: e2314245121. PMID 38194460 DOI: 10.1073/pnas.2314245121  0.547
2023 Lumpkin RJ, Baker RW, Leschziner AE, Komives EA. Author Correction: Structure and dynamics of the ASB9 CUL-RING E3 Ligase. Nature Communications. 14: 7463. PMID 37978300 DOI: 10.1038/s41467-023-43056-x  0.417
2023 Reimer JM, Dickey AM, Lin YX, Abrisch RG, Mathea S, Chatterjee D, Fay EJ, Knapp S, Daugherty MD, Reck-Peterson SL, Leschziner AE. Structure of LRRK1 and mechanisms of autoinhibition and activation. Nature Structural & Molecular Biology. PMID 37857821 DOI: 10.1038/s41594-023-01109-1  0.62
2023 Karasmanis EP, Reimer JM, Kendrick AA, Nguyen KHV, Rodriguez JA, Truong JB, Lahiri I, Reck-Peterson SL, Leschziner AE. Lis1 relieves cytoplasmic dynein-1 autoinhibition by acting as a molecular wedge. Nature Structural & Molecular Biology. PMID 37620585 DOI: 10.1038/s41594-023-01069-6  0.765
2023 Reimer JM, DeSantis ME, Reck-Peterson SL, Leschziner AE. Structures of human dynein in complex with the lissencephaly 1 protein, LIS1. Elife. 12. PMID 36692009 DOI: 10.7554/eLife.84302  0.64
2022 Snead DM, Matyszewski M, Dickey AM, Lin YX, Leschziner AE, Reck-Peterson SL. Structural basis for Parkinson's disease-linked LRRK2's binding to microtubules. Nature Structural & Molecular Biology. 29: 1196-1207. PMID 36510024 DOI: 10.1038/s41594-022-00863-y  0.646
2022 Gillies JP, Reimer JM, Karasmanis EP, Lahiri I, Htet ZM, Leschziner AE, Reck-Peterson SL. Structural basis for cytoplasmic dynein-1 regulation by Lis1. Elife. 11. PMID 34994688 DOI: 10.7554/eLife.71229  0.784
2021 Arakawa T, Tokunaga M, Kita Y, Niikura T, Baker RW, Reimer JM, Leschziner AE. Structure Analysis of Proteins and Peptides by Difference Circular Dichroism Spectroscopy. The Protein Journal. PMID 34709521 DOI: 10.1007/s10930-021-10024-7  0.443
2021 Leschziner AE, Reck-Peterson SL. Scientific Perspectives: Structural Biology of LRRK2 and its Interaction with Microtubules. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 34423856 DOI: 10.1002/mds.28755  0.635
2021 Sharon I, Haque AS, Grogg M, Lahiri I, Seebach D, Leschziner AE, Hilvert D, Schmeing TM. Structures and function of the amino acid polymerase cyanophycin synthetase. Nature Chemical Biology. PMID 34385683 DOI: 10.1038/s41589-021-00854-y  0.696
2020 Baker RW, Reimer JM, Carman PJ, Turegun B, Arakawa T, Dominguez R, Leschziner AE. Structural insights into assembly and function of the RSC chromatin remodeling complex. Nature Structural & Molecular Biology. PMID 33288924 DOI: 10.1038/s41594-020-00528-8  0.57
2020 Deniston CK, Salogiannis J, Mathea S, Snead DM, Lahiri I, Matyszewski M, Donosa O, Watanabe R, Böhning J, Shiau AK, Knapp S, Villa E, Reck-Peterson SL, Leschziner AE. Structure of LRRK2 in Parkinson's disease and model for microtubule interaction. Nature. PMID 32814344 DOI: 10.1038/S41586-020-2673-2  0.772
2020 Lumpkin RJ, Baker RW, Leschziner AE, Komives EA. Structure and dynamics of the ASB9 CUL-RING E3 Ligase. Nature Communications. 11: 2866. PMID 32513959 DOI: 10.1038/S41467-020-16499-9  0.528
2020 Htet ZM, Gillies JP, Baker RW, Leschziner AE, DeSantis ME, Reck-Peterson SL. LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes. Nature Cell Biology. PMID 32341549 DOI: 10.1038/S41556-020-0506-Z  0.754
2020 Wilhelm J, Carver M, Kyriakakis P, Monfort E, Barry R, Leschziner A. Identification Of An Actin Fold Containing Metabolic Enzyme That Undergoes Regulated Polymerization The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00655  0.754
2020 Deniston CK, Leschziner A, Salogiannis J, Snead D, Lahiri I. A Structural and Mechanistic Model for the Interaction of Parkinson's Disease-Related LRRK2 with Microtubules Biophysical Journal. 118: 501a. DOI: 10.1016/J.Bpj.2019.11.2764  0.612
2019 Partlow EA, Baker RW, Beacham GM, Chappie JS, Leschziner AE, Hollopeter G. A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex. Elife. 8. PMID 31464684 DOI: 10.7554/Elife.50003  0.567
2019 Lahiri I, Xu J, Han BG, Oh J, Wang D, DiMaio F, Leschziner AE. 3.1Å structure of yeast RNA polymerase II elongation complex stalled at a cyclobutane pyrimidine dimer lesion solved using streptavidin affinity grids. Journal of Structural Biology. PMID 31200019 DOI: 10.1016/j.jsb.2019.06.004  0.573
2019 Partlow EA, Baker RW, Beacham GM, Chappie JS, Leschziner AE, Hollopeter G. Author response: A structural mechanism for phosphorylation-dependent inactivation of the AP2 complex Elife. DOI: 10.7554/Elife.50003.032  0.547
2019 Lahiri I, Xu J, Han BG, Oh J, Wang D, DiMaio F, Leschziner AE. 3.1 angstrom structure of yeast RNA polymerase II elongation complex stalled at a cyclobutane pyrimidine dimer lesion solved using streptavidin affinity grids. Journal of Structural Biology. 207: 270-278. DOI: 10.2210/Pdb6O6C/Pdb  0.61
2018 Cianfrocco MA, Lahiri I, DiMaio F, Leschziner AE. cryoem-cloud-tools: A software platform to deploy and manage cryo-EM jobs in the cloud. Journal of Structural Biology. PMID 29864529 DOI: 10.2210/Pdb6Drv/Pdb  0.748
2018 Turegun B, Baker RW, Leschziner AE, Dominguez R. Actin-related proteins regulate the RSC chromatin remodeler by weakening intramolecular interactions of the Sth1 ATPase. Communications Biology. 1. PMID 29809203 DOI: 10.1038/s42003-017-0002-6  0.55
2018 Htet ZM, DeSantis ME, Cianfrocco MA, Tran PT, Leschziner AE, Reck-Peterson SL. Two Opposing Modes of Cytoplasmic Dynein Regulation by Lis1 Biophysical Journal. 114: 512a. DOI: 10.1016/J.Bpj.2017.11.2797  0.759
2018 Reck-Peterson S, Leschziner A, DeSantis M, Cianfrocco M, Min Htet Z, Tien Tran P. Mechanisms of Regulating Cytoplasmic Dynein Biophysical Journal. 114: 9a. DOI: 10.1016/J.Bpj.2017.11.088  0.78
2017 Xu J, Lahiri I, Wang W, Wier A, Cianfrocco MA, Chong J, Hare AA, Dervan PB, DiMaio F, Leschziner AE, Wang D. Structural basis for the initiation of eukaryotic transcription-coupled DNA repair. Nature. PMID 29168508 DOI: 10.1038/Nature24658  0.781
2017 Xu J, Lahiri I, Wang W, Wier A, Cianfrocco MA, Chong J, Hare AA, Dervan PB, DiMaio F, Leschziner AE, Wang D. Structural basis for the initiation of eukaryotic transcription-coupled DNA repair. Nature. PMID 29168508 DOI: 10.1038/Nature24658  0.781
2017 DeSantis ME, Cianfrocco MA, Htet ZM, Tran PT, Reck-Peterson SL, Leschziner AE. Lis1 Has Two Opposing Modes of Regulating Cytoplasmic Dynein. Cell. 170: 1197-1208.e12. PMID 28886386 DOI: 10.1016/J.Cell.2017.08.037  0.812
2017 Cui J, Zhu Q, Zhang H, Cianfrocco MA, Leschziner AE, Dixon JE, Xiao J. Structure of Fam20A reveals a pseudokinase featuring unique disulfide pattern and inverted ATP-binding. Elife. 6. PMID 28432788 DOI: 10.7554/Elife.23990  0.793
2017 Cui J, Zhu Q, Zhang H, Cianfrocco MA, Leschziner AE, Dixon JE, Xiao J. Author response: Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding Elife. DOI: 10.7554/Elife.23990.019  0.335
2017 Cianfrocco MA, DeSantis ME, Htet ZM, Tran PT, Leschziner AE, Reck-Peterson SL. Lis1 has Two Distinct Modes of Regulating Dynein's Mechanochemical Cycle Biophysical Journal. 112: 43a. DOI: 10.1016/J.Bpj.2016.11.274  0.817
2015 Cianfrocco MA, DeSantis ME, Leschziner AE, Reck-Peterson SL. Mechanism and Regulation of Cytoplasmic Dynein. Annual Review of Cell and Developmental Biology. PMID 26436706 DOI: 10.1146/Annurev-Cellbio-100814-125438  0.806
2015 Cianfrocco MA, Leschziner AE. Low cost, high performance processing of single particle cryo-electron microscopy data in the cloud. Elife. 4. PMID 25955969 DOI: 10.7554/Elife.06664  0.766
2015 Toropova K, Zou S, Roberts AJ, Reck-Peterson SL, Leschziner AE. Regulation of Cytoplasmic Dynein by Lisl Microscopy and Microanalysis. 21: 59-60. DOI: 10.1017/S1431927615001099  0.675
2014 Toropova K, Zou S, Roberts AJ, Redwine WB, Goodman BS, Reck-Peterson SL, Leschziner AE. Lis1 regulates dynein by sterically blocking its mechanochemical cycle. Elife. 3. PMID 25380312 DOI: 10.7554/Elife.03372  0.771
2014 Cianfrocco MA, Leschziner AE. Traffic control: adaptor proteins guide dynein-cargo takeoff. The Embo Journal. 33: 1845-6. PMID 25061224 DOI: 10.15252/Embj.201489450  0.797
2014 Toropova K, Zou S, Roberts AJ, Redwine WB, Goodman BS, Reck-Peterson SL, Leschziner AE. Author response: Lis1 regulates dynein by sterically blocking its mechanochemical cycle Elife. DOI: 10.7554/Elife.03372.023  0.762
2014 Zou S, Toropova K, Roberts AJ, Reck-Peterson SL, Leschziner AE. Lis1 Regulates Dynein as a Molecular Wedge Biophysical Journal. 106: 353a. DOI: 10.1016/J.Bpj.2013.11.2006  0.737
2013 Nguyen VQ, Ranjan A, Stengel F, Wei D, Aebersold R, Wu C, Leschziner AE. Molecular architecture of the ATP-dependent chromatin-remodeling complex SWR1. Cell. 154: 1220-31. PMID 24034246 DOI: 10.1016/J.Cell.2013.08.018  0.649
2012 Derr ND, Goodman BS, Jungmann R, Leschziner AE, Shih WM, Reck-Peterson SL. Tug-of-war in motor protein ensembles revealed with a programmable DNA origami scaffold. Science (New York, N.Y.). 338: 662-5. PMID 23065903 DOI: 10.1126/Science.1226734  0.657
2012 Redwine WB, Hernández-López R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE. Structural basis for microtubule binding and release by dynein. Science (New York, N.Y.). 337: 1532-6. PMID 22997337 DOI: 10.1126/Science.1224151  0.792
2012 Huang J, Roberts AJ, Leschziner AE, Reck-Peterson SL. Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor. Cell. 150: 975-86. PMID 22939623 DOI: 10.1016/J.Cell.2012.07.022  0.727
2012 Redwine WB, Hernandez-Lopez R, Reck-Peterson SL, Leschziner AE. Structural Basis for the Regulation of Microtubule-Binding Affinity by Cytoplasmic Dynein Biophysical Journal. 102: 367a. DOI: 10.1016/J.Bpj.2011.11.2006  0.796
2012 Reck-Peterson SL, Huang J, Roberts AJ, Leschziner AE. Lis1 Uncouples Allosteric Communication Between Dynein's AAA+ Motor and Microtubule Binding Domains Biophysical Journal. 102: 20a. DOI: 10.1016/J.Bpj.2011.11.135  0.733
2011 Leschziner AE. Electron microscopy studies of nucleosome remodelers. Current Opinion in Structural Biology. 21: 709-18. PMID 22040801 DOI: 10.1016/J.Sbi.2011.10.002  0.415
2011 Chandramouli P, Hernandez-Lopez R, Wang HW, Leschziner AE. Validation of the orthogonal tilt reconstruction method with a biological test sample. Journal of Structural Biology. 175: 85-96. PMID 21536134 DOI: 10.1016/J.Jsb.2011.04.012  0.769
2007 Wang HW, Ramey VH, Westermann S, Leschziner AE, Welburn JP, Nakajima Y, Drubin DG, Barnes G, Nogales E. Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms. Nature Structural & Molecular Biology. 14: 721-6. PMID 17643123 DOI: 10.1038/Nsmb1274  0.795
2007 Leschziner AE, Saha A, Wittmeyer J, Zhang Y, Bustamante C, Cairns BR, Nogales E. Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method. Proceedings of the National Academy of Sciences of the United States of America. 104: 4913-8. PMID 17360331 DOI: 10.1073/Pnas.0700706104  0.581
2007 Leschziner AE, Nogales E. Visualizing flexibility at molecular resolution: analysis of heterogeneity in single-particle electron microscopy reconstructions. Annual Review of Biophysics and Biomolecular Structure. 36: 43-62. PMID 17201674 DOI: 10.1146/Annurev.Biophys.36.040306.132742  0.504
2006 Clarey MG, Erzberger JP, Grob P, Leschziner AE, Berger JM, Nogales E, Botchan M. Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nature Structural & Molecular Biology. 13: 684-90. PMID 16829958 DOI: 10.1038/Nsmb1121  0.582
2006 Leschziner AE, Nogales E. The orthogonal tilt reconstruction method: an approach to generating single-class volumes with no missing cone for ab initio reconstruction of asymmetric particles. Journal of Structural Biology. 153: 284-99. PMID 16431136 DOI: 10.1016/J.Jsb.2005.10.012  0.497
2005 Leschziner AE, Lemon B, Tjian R, Nogales E. Structural studies of the human PBAF chromatin-remodeling complex. Structure (London, England : 1993). 13: 267-75. PMID 15698570 DOI: 10.1016/J.Str.2004.12.008  0.602
2003 Leschziner AE, Grindley ND. The architecture of the gammadelta resolvase crossover site synaptic complex revealed by using constrained DNA substrates. Molecular Cell. 12: 775-81. PMID 14527421 DOI: 10.1016/S1097-2765(03)00351-4  0.629
2001 Sarkis GJ, Murley LL, Leschziner AE, Boocock MR, Stark WM, Grindley ND. A model for the gamma delta resolvase synaptic complex. Molecular Cell. 8: 623-31. PMID 11583624 DOI: 10.1016/S1097-2765(01)00334-3  0.61
2001 Xu Y, Potapova O, Leschziner AE, Grindley ND, Joyce CM. Contacts between the 5' nuclease of DNA polymerase I and its DNA substrate. The Journal of Biological Chemistry. 276: 30167-77. PMID 11349126 DOI: 10.1074/Jbc.M100985200  0.615
1999 Griffin TJ, Parsons L, Leschziner AE, DeVost J, Derbyshire KM, Grindley ND. In vitro transposition of Tn552: a tool for DNA sequencing and mutagenesis. Nucleic Acids Research. 27: 3859-65. PMID 10481025 DOI: 10.1093/Nar/27.19.3859  0.583
1998 Leschziner AE, Griffin TJ, Grindley ND. Tn552 transposase catalyzes concerted strand transfer in vitro. Proceedings of the National Academy of Sciences of the United States of America. 95: 7345-50. PMID 9636151 DOI: 10.1073/Pnas.95.13.7345  0.6
1995 Grindley ND, Leschziner AE. DNA transposition: from a black box to a color monitor. Cell. 83: 1063-6. PMID 8548793 DOI: 10.1016/0092-8674(95)90132-9  0.555
1995 Leschziner AE, Boocock MR, Grindley ND. The tyrosine-6 hydroxyl of gamma delta resolvase is not required for the DNA cleavage and rejoining reactions. Molecular Microbiology. 15: 865-70. PMID 7596288 DOI: 10.1111/J.1365-2958.1995.Tb02356.X  0.603
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