Paul Grof - Publications

Affiliations: 
Psychiatry University of Ottawa, Ottawa, ON, Canada 

212 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Duffy A, Grof P. Advancing clinical practice and discovery research through revised taxonomy: Case in point bipolar disorder diagnosis: Commentary on "The diagnosis of bipolar disorder in children and adolescents: Past, present and future". Bipolar Disorders. PMID 38453170 DOI: 10.1111/bdi.13415  0.642
2024 Ou AH, Rosenthal SB, Adli M, Akiyama K, Akula N, Alda M, Amare AT, Ardau R, Arias B, Aubry JM, Backlund L, Bauer M, Baune BT, Bellivier F, Benabarre A, ... ... Grof P, et al. Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study. Translational Psychiatry. 14: 109. PMID 38395906 DOI: 10.1038/s41398-024-02811-4  0.74
2023 Herrera-Rivero M, Adli M, Akiyama K, Akula N, Amare AT, Ardau R, Arias B, Aubry JM, Backlund L, Bellivier F, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, ... ... Grof P, et al. Exploring the genetics of lithium response in bipolar disorders. Research Square. PMID 38077040 DOI: 10.21203/rs.3.rs-3677630/v1  0.739
2023 Kelsoe J, Ou A, Rosenthal S, Adli M, Akiyama K, Akula N, Alda M, Amare AT, Ardau R, Arias B, Aubry JM, Backlund L, Banzato C, Bauer M, Baune B, ... ... Grof P, et al. Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study. Research Square. PMID 37886563 DOI: 10.21203/rs.3.rs-3258813/v1  0.74
2023 Bauer M, Glenn T, Alda M, Grof P, Bauer R, Ebner-Priemer UW, Ehrlich S, Pfennig A, Pilhatsch M, Rasgon N, Whybrow PC. Longitudinal Digital Mood Charting in Bipolar Disorder: Experiences with ChronoRecord Over 20 Years. Pharmacopsychiatry. 56: 182-187. PMID 37678394 DOI: 10.1055/a-2156-5667  0.565
2023 Herrera-Rivero M, Gutiérrez-Fragoso K, Thalamuthu A, Amare AT, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Aubry JM, Backlund L, Bellivier F, Benabarre A, Bengesser S, Abesh B, ... ... Grof P, et al. Immunogenetics of lithium response and psychiatric phenotypes in patients with bipolar disorder. Research Square. PMID 37461719 DOI: 10.21203/rs.3.rs-3068352/v1  0.738
2023 Brancati GE, Nunes A, Scott K, O'Donovan C, Cervantes P, Grof P, Alda M. Differential characteristics of bipolar I and II disorders: a retrospective, cross-sectional evaluation of clinical features, illness course, and response to treatment. International Journal of Bipolar Disorders. 11: 25. PMID 37452256 DOI: 10.1186/s40345-023-00304-9  0.844
2023 Amare AT, Thalamuthu A, Schubert KO, Fullerton JM, Ahmed M, Hartmann S, Papiol S, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hou L, Hsu YH, Shekhtman T, Adli M, Akula N, ... ... Grof P, et al. Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder. Molecular Psychiatry. PMID 37433967 DOI: 10.1038/s41380-023-02149-1  0.746
2023 Bauer M, Glenn T, Achtyes ED, Alda M, Agaoglu E, Altınbaş K, Andreassen OA, Angelopoulos E, Ardau R, Aydin M, Ayhan Y, Baethge C, Bauer R, Baune BT, Balaban C, ... ... Grof P, et al. Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder. International Journal of Bipolar Disorders. 11: 22. PMID 37347392 DOI: 10.1186/s40345-023-00303-w  0.614
2023 Amare A, Thalamuthu A, Schubert KO, Fullerton J, Ahmed M, Hartmann S, Papiol S, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hou L, Hsu YH, Shekhtman T, Adli M, Akula N, ... ... Grof P, et al. Association of Polygenic Score and the involvement of Cholinergic and Glutamatergic Pathways with Lithium Treatment Response in Patients with Bipolar Disorder. Research Square. PMID 36824922 DOI: 10.21203/rs.3.rs-2580252/v1  0.762
2022 Kovacs Z, Vestergaard P, W Licht R, P V Straszek S, Hansen AS, H Young A, Duffy A, Müller-Oerlinghausen B, Seemueller F, Sani G, Rubakowski J, Priller J, Vedel Kessing L, Tondo L, Alda M, ... ... Grof P, et al. Lithium induced hypercalcemia: an expert opinion and management algorithm. International Journal of Bipolar Disorders. 10: 34. PMID 36547749 DOI: 10.1186/s40345-022-00283-3  0.773
2022 Bauer M, Glenn T, Achtyes ED, Alda M, Agaoglu E, Altınbaş K, Andreassen OA, Angelopoulos E, Ardau R, Aydin M, Ayhan Y, Baethge C, Bauer R, Baune BT, Balaban C, ... ... Grof P, et al. Association between polarity of first episode and solar insolation in bipolar I disorder. Journal of Psychosomatic Research. 160: 110982. PMID 35932492 DOI: 10.1016/j.jpsychores.2022.110982  0.669
2022 Schubert KO, Thalamuthu A, Amare AT, Frank J, Streit F, Adl M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, ... ... Grof P, et al. Correction: Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients. Translational Psychiatry. 12: 278. PMID 35817769 DOI: 10.1038/s41398-022-02037-2  0.749
2022 Cearns M, Amare AT, Schubert KO, Thalamuthu A, Frank J, Streit F, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry J, Backlund L, Bhattacharjee AK, Bellivier F, ... ... Grof P, et al. Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach - CORRIGENDUM. The British Journal of Psychiatry : the Journal of Mental Science. 1. PMID 35505515 DOI: 10.1192/bjp.2022.55  0.731
2022 Cearns M, Amare AT, Schubert KO, Thalamuthu A, Frank J, Streit F, Adli M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, ... ... Grof P, et al. Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: machine learning approach. The British Journal of Psychiatry : the Journal of Mental Science. 1-10. PMID 35225756 DOI: 10.1192/bjp.2022.28  0.757
2022 Kalman JL, Yoshida T, Andlauer TFM, Schulte EC, Adorjan K, Alda M, Ardau R, Aubry JM, Brosch K, Budde M, Chillotti C, Czerski PM, DePaulo RJ, Forstner A, Goes FS, ... ... Grof P, et al. Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses. European Archives of Psychiatry and Clinical Neuroscience. PMID 35146571 DOI: 10.1007/s00406-021-01366-5  0.585
2021 Coombes BJ, Millischer V, Batzler A, Larrabee B, Hou L, Papiol S, Heilbronner U, Adli M, Akiyama K, Akula N, Amare AT, Ardau R, Arias B, Aubry JM, Backlund L, ... ... Grof P, et al. Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study. Complex Psychiatry. 7: 80-89. PMID 36408127 DOI: 10.1159/000519707  0.76
2021 Kalman JL, Olde Loohuis LM, Vreeker A, McQuillin A, Stahl EA, Ruderfer D, Grigoroiu-Serbanescu M, Panagiotaropoulou G, Ripke S, Bigdeli TB, Stein F, Meller T, Meinert S, Pelin H, Streit F, ... ... Grof P, et al. Characterisation of age and polarity at onset in bipolar disorder. The British Journal of Psychiatry : the Journal of Mental Science. 219: 659-669. PMID 35048876 DOI: 10.1192/bjp.2021.102  0.823
2021 Schubert KO, Thalamuthu A, Amare AT, Frank J, Streit F, Adl M, Akula N, Akiyama K, Ardau R, Arias B, Aubry JM, Backlund L, Bhattacharjee AK, Bellivier F, Benabarre A, ... ... Grof P, et al. Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients. Translational Psychiatry. 11: 606. PMID 34845190 DOI: 10.1038/s41398-021-01702-2  0.778
2021 Le Clerc S, Lombardi L, Baune BT, Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Cearns M, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, ... ... Grof P, et al. HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders. Scientific Reports. 11: 17823. PMID 34497278 DOI: 10.1038/s41598-021-97140-7  0.724
2021 Bauer M, Glenn T, Achtyes ED, Alda M, Agaoglu E, Altınbaş K, Andreassen OA, Angelopoulos E, Ardau R, Vares EA, Aydin M, Ayhan Y, Baethge C, Bauer R, Baune BT, ... ... Grof P, et al. Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder. International Journal of Bipolar Disorders. 9: 26. PMID 34467430 DOI: 10.1186/s40345-021-00231-7  0.713
2021 Keown-Stoneman CDG, Goodday SM, Preisig M, Vandeleur C, Castelao E, Grof P, Horrocks J, King N, Duffy A. Development and validation of a risk calculator for major mood disorders among the offspring of bipolar parents using information collected in routine clinical practice. Eclinicalmedicine. 39: 101083. PMID 34466794 DOI: 10.1016/j.eclinm.2021.101083  0.623
2021 Stone W, Nunes A, Akiyama K, Akula N, Ardau R, Aubry JM, Backlund L, Bauer M, Bellivier F, Cervantes P, Chen HC, Chillotti C, Cruceanu C, Dayer A, Degenhardt F, ... ... Grof P, et al. Prediction of lithium response using genomic data. Scientific Reports. 11: 1155. PMID 33441847 DOI: 10.1038/s41598-020-80814-z  0.781
2021 Nunes A, Stone W, Ardau R, Berghöfer A, Bocchetta A, Chillotti C, Deiana V, Degenhardt F, Forstner AJ, Garnham JS, Grof E, Hajek T, Manchia M, Mattheisen M, McMahon F, ... ... Grof P, et al. Exemplar scoring identifies genetically separable phenotypes of lithium responsive bipolar disorder. Translational Psychiatry. 11: 36. PMID 33431852 DOI: 10.1038/s41398-020-01148-y  0.81
2020 Bauer M, Glenn T, Alda M, Grof P, Monteith S, Rasgon N, Severus E, Whybrow PC. Association between Adherence with an Atypical Antipsychotic and with Other Psychiatric Drugs in Patients with Bipolar Disorder. Pharmacopsychiatry. PMID 33202423 DOI: 10.1055/a-1257-0813  0.501
2020 Grof P, Duffy A. Lithium stabilization and misunderstandings: Toward understanding why lithium is underutilized. Bipolar Disorders. PMID 32976678 DOI: 10.1111/bdi.13000  0.583
2020 Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Cearns M, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, ... ... Grof P, et al. Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Molecular Psychiatry. PMID 32203155 DOI: 10.1038/S41380-020-0689-5  0.774
2019 Nunes A, Ardau R, Berghöfer A, Bocchetta A, Chillotti C, Deiana V, Garnham J, Grof E, Hajek T, Manchia M, Müller-Oerlinghausen B, Pinna M, Pisanu C, O'Donovan C, Severino G, ... ... Grof P, et al. Prediction of Lithium Response using Clinical Data. Acta Psychiatrica Scandinavica. PMID 31667829 DOI: 10.1111/Acps.13122  0.806
2019 Bauer M, Glenn T, Alda M, Bauer R, Grof P, Marsh W, Monteith S, Munoz R, Rasgon N, Sagduyu K, Whybrow PC. Trajectories of adherence to mood stabilizers in patients with bipolar disorder. International Journal of Bipolar Disorders. 7: 19. PMID 31482209 DOI: 10.1186/S40345-019-0154-Z  0.599
2019 Tondo L, Alda M, Bauer M, Bergink V, Grof P, Hajek T, Lewitka U, Licht RW, Manchia M, Müller-Oerlinghausen B, Nielsen RE, Selo M, Simhandl C, Baldessarini RJ. Clinical use of lithium salts: guide for users and prescribers. International Journal of Bipolar Disorders. 7: 16. PMID 31328245 DOI: 10.1186/S40345-019-0151-2  0.779
2019 Bauer M, Glenn T, Alda M, Andreassen OA, Angelopoulos E, Ardau R, Ayhan Y, Baethge C, Bauer R, Baune BT, Becerra-Palars C, Bellivier F, Belmaker RH, Berk M, Bersudsky Y, ... ... Grof P, et al. Association between solar insolation and a history of suicide attempts in bipolar I disorder. Journal of Psychiatric Research. 113: 1-9. PMID 30878786 DOI: 10.1016/J.Jpsychires.2019.03.001  0.704
2019 Grof P. Book Review: Hoarding Disorder: The Canadian Journal of Psychiatry. 70674371984535. DOI: 10.1177/0706743719845350  0.471
2019 Duffy AC, Goodday S, Keown-Stoneman C, Grof P. 28.1 THE DEVELOPMENTAL TRAJECTORY OF BIPOLAR DISORDER: LATEST OBSERVATIONS FROM THE CANADIAN FLOURISH HIGH-RISK STUDY Journal of the American Academy of Child & Adolescent Psychiatry. 58: S341-S342. DOI: 10.1016/J.Jaac.2019.07.813  0.696
2018 Duffy A, Goodday S, Keown-Stoneman C, Grof P. The Emergent Course of Bipolar Disorder: Observations Over Two Decades From the Canadian High-Risk Offspring Cohort. The American Journal of Psychiatry. appiajp201818040461. PMID 30525908 DOI: 10.1176/Appi.Ajp.2018.18040461  0.7
2018 Duffy A, Keown-Stoneman C, Goodday SM, Saunders K, Horrocks J, Grof P, Weir A, Hinds C, Geddes J. Daily and weekly mood ratings using a remote capture method in high-risk offspring of bipolar parents: Compliance and symptom monitoring. Bipolar Disorders. PMID 30422376 DOI: 10.1111/Bdi.12721  0.632
2018 Goodday SM, Preisig M, Gholamrezaee M, Grof P, Duffy A. Temperament and self-esteem in high-risk offspring of bipolar parents: Vulnerability and scar effects. Journal of Affective Disorders. 243: 209-215. PMID 30245253 DOI: 10.1016/J.Jad.2018.09.035  0.61
2018 Duffy A, Grof P. Commentary on McGorry et al.'s Debate on: "Is 'early intervention' in bipolar disorder what it claims to be?" Bipolar Disorders. 20: 556-557. PMID 30221464 DOI: 10.1111/Bdi.12643  0.615
2018 Bauer R, Glenn T, Strejilevich S, Conell J, Alda M, Ardau R, Baune BT, Berk M, Bersudsky Y, Bilderbeck A, Bocchetta A, Castro AMP, Cheung EYW, Chillotti C, Choppin S, ... ... Grof P, et al. Internet use by older adults with bipolar disorder: international survey results. International Journal of Bipolar Disorders. 6: 20. PMID 30178112 DOI: 10.1186/S40345-018-0127-7  0.703
2018 Reinbold CS, Forstner AJ, Hecker J, Fullerton JM, Hoffmann P, Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Benabarre A, ... ... Grof P, et al. Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder. Frontiers in Psychiatry. 9: 207. PMID 29904359 DOI: 10.3389/Fpsyt.2018.00207  0.707
2018 Pilhatsch M, Glenn T, Rasgon N, Alda M, Sagduyu K, Grof P, Munoz R, Marsh W, Monteith S, Severus E, Bauer R, Ritter P, Whybrow PC, Bauer M. Regularity of self-reported daily dosage of mood stabilizers and antipsychotics in patients with bipolar disorder. International Journal of Bipolar Disorders. 6: 10. PMID 29713845 DOI: 10.1186/S40345-018-0118-8  0.625
2018 Duffy A, Grof P. Lithium Treatment in Children and Adolescents. Pharmacopsychiatry. PMID 29490377 DOI: 10.1055/A-0575-4179  0.643
2018 Duffy AC, Goodday SM, Grof P, Keown-Stoneman C. 26.1 Clinical Trajectory of Developing Bipolar Disorder: Observations of Up to 22 Years in High-Risk Offspring of Parents With Bipolar Disorder in Canada Journal of the American Academy of Child & Adolescent Psychiatry. 57: S309. DOI: 10.1016/J.Jaac.2018.07.764  0.711
2017 Mühleisen TW, Reinbold CS, Forstner AJ, Abramova LI, Alda M, Babadjanova G, Bauer M, Brennan P, Chuchalin A, Cruceanu C, Czerski PM, Degenhardt F, Fischer SB, Fullerton JM, Gordon SD, ... ... Grof P, et al. Gene set enrichment analysis and expression pattern exploration implicate an involvement of neurodevelopmental processes in bipolar disorder. Journal of Affective Disorders. 228: 20-25. PMID 29197740 DOI: 10.1016/J.Jad.2017.11.068  0.69
2017 Amare AT, Schubert KO, Hou L, Clark SR, Papiol S, Heilbronner U, Degenhardt F, Tekola-Ayele F, Hsu YH, Shekhtman T, Adli M, Akula N, Akiyama K, Ardau R, ... ... Grof P, et al. Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study. Jama Psychiatry. PMID 29121268 DOI: 10.1001/Jamapsychiatry.2017.3433  0.78
2017 Bauer M, Glenn T, Alda M, Aleksandrovich MA, Andreassen OA, Angelopoulos E, Ardau R, Ayhan Y, Baethge C, Bharathram SR, Bauer R, Baune BT, Becerra-Palars C, Bellivier F, Belmaker RH, ... ... Grof P, et al. Solar insolation in springtime influences age of onset of bipolar I disorder. Acta Psychiatrica Scandinavica. PMID 28722128 DOI: 10.1111/Acps.12772  0.728
2017 Bauer R, Conell J, Glenn T, Alda M, Ardau R, Baune BT, Berk M, Bersudsky Y, Bilderbeck A, Bocchetta A, Bossini L, Castro AMP, Cheung EYW, Chillotti C, Choppin S, ... ... Grof P, et al. International multi-site survey on the use of online support groups in bipolar disorder. Nordic Journal of Psychiatry. 1-4. PMID 28696841 DOI: 10.1080/08039488.2017.1334819  0.732
2017 Conell J, Bauer R, Glenn T, Alda M, Ardau R, Baune BT, Berk M, Bersudsky Y, Bilderbeck A, Bocchetta A, Bossini L, Paredes Castro AM, Cheung EY, Chillotti C, Choppin S, ... ... Grof P, et al. Erratum to: Online information seeking by patients with bipolar disorder: results from an international multisite survey. International Journal of Bipolar Disorders. 5: 18. PMID 28364388 DOI: 10.1186/S40345-017-0082-8  0.742
2017 Goodday SM, Preisig M, Gholamrezaee M, Grof P, Angst J, Duffy A. The association between self-reported and clinically determined hypomanic symptoms and the onset of major mood disorders. Bjpsych Open. 3: 71-77. PMID 28357133 DOI: 10.1192/Bjpo.Bp.116.004234  0.697
2016 Ortiz A, Grof P. Electronic monitoring of self-reported mood: the return of the subjective? International Journal of Bipolar Disorders. 4: 28. PMID 27900735 DOI: 10.1186/S40345-016-0069-X  0.697
2016 Conell J, Bauer R, Glenn T, Alda M, Ardau R, Baune BT, Berk M, Bersudsky Y, Bilderbeck A, Bocchetta A, Bossini L, Paredes Castro AM, Cheung EY, Chillotti C, Choppin S, ... ... Grof P, et al. Online information seeking by patients with bipolar disorder: results from an international multisite survey. International Journal of Bipolar Disorders. 4: 17. PMID 27552813 DOI: 10.1186/S40345-016-0058-0  0.719
2016 Bauer R, Conell J, Glenn T, Alda M, Ardau R, Baune BT, Berk M, Bersudsky Y, Bilderbeck A, Bocchetta A, Bossini L, Castro AM, Cheung EY, Chillotti C, Choppin S, ... ... Grof P, et al. Internet use by patients with bipolar disorder: Results from an international multisite survey. Psychiatry Research. 242: 388-394. PMID 27391371 DOI: 10.1016/J.Psychres.2016.05.055  0.735
2016 Duffy A, Malhi GS, Grof P. Do the Trajectories of Bipolar Disorder and Schizophrenia Follow a Universal Staging Model? Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie. PMID 27310243 DOI: 10.1177/0706743716649189  0.668
2016 Goodday SM, Horrocks J, Keown-Stoneman C, Grof P, Duffy A. Repeated salivary daytime cortisol and onset of mood episodes in offspring of bipolar parents. International Journal of Bipolar Disorders. 4: 12. PMID 27230036 DOI: 10.1186/S40345-016-0053-5  0.668
2016 Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato CE, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, ... ... Grof P, et al. Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study. Lancet (London, England). PMID 26806518 DOI: 10.1016/S0140-6736(16)00143-4  0.778
2015 Haussmann R, Bauer M, von Bonin S, Grof P, Lewitzka U. Treatment of lithium intoxication: facing the need for evidence. International Journal of Bipolar Disorders. 3: 23. PMID 26493348 DOI: 10.1186/S40345-015-0040-2  0.373
2015 Goodday S, Levy A, Flowerdew G, Horrocks J, Grof P, Ellenbogen M, Duffy A. Early exposure to parental bipolar disorder and risk of mood disorder: the Flourish Canadian prospective offspring cohort study. Early Intervention in Psychiatry. PMID 26486425 DOI: 10.1111/Eip.12291  0.686
2015 Keown-Stoneman CD, Horrocks J, Darlington GA, Goodday S, Grof P, Duffy A. Multi-state models for investigating possible stages leading to bipolar disorder. International Journal of Bipolar Disorders. 3: 5. PMID 25713772 DOI: 10.1186/S40345-014-0019-4  0.68
2015 Grof P. Book Review: Bipolar Disorder: Clinician's Guide to Bipolar Disorder: Integrating Pharmacology and Psychotherapy The Canadian Journal of Psychiatry. 60: 92-92. DOI: 10.1177/070674371506000208  0.521
2014 Duffy A, Horrocks J, Doucette S, Keown-Stoneman C, Grof P, Andreazza A, Young LT. Immunological and neurotrophic markers of risk status and illness development in high-risk youth: understanding the neurobiological underpinnings of bipolar disorder. International Journal of Bipolar Disorders. 2: 29. PMID 26092400 DOI: 10.1186/2194-7511-2-4  0.673
2014 Doucette S, Levy A, Flowerdew G, Horrocks J, Grof P, Ellenbogen M, Duffy A. Early parent-child relationships and risk of mood disorder in a Canadian sample of offspring of a parent with bipolar disorder: findings from a 16-year prospective cohort study. Early Intervention in Psychiatry. PMID 25356767 DOI: 10.1111/Eip.12195  0.651
2014 Duffy A, Horrocks J, Keown-Stoneman C, Doucette S, Grof P. Authors' reply British Journal of Psychiatry. 205: 159. PMID 25252323 DOI: 10.1192/bjp.205.2.159  0.512
2014 Mühleisen TW, Leber M, Schulze TG, Strohmaier J, Degenhardt F, Treutlein J, Mattheisen M, Forstner AJ, Schumacher J, Breuer R, Meier S, Herms S, Hoffmann P, Lacour A, Witt SH, ... ... Grof P, et al. Genome-wide association study reveals two new risk loci for bipolar disorder. Nature Communications. 5: 3339. PMID 24618891 DOI: 10.1038/Ncomms4339  0.647
2014 Duffy A, Horrocks J, Doucette S, Keown-Stoneman C, McCloskey S, Grof P. The developmental trajectory of bipolar disorder British Journal of Psychiatry. 204: 122-128. PMID 24262817 DOI: 10.1192/Bjp.Bp.113.126706  0.699
2014 Grof P, Müller-Oerlinghausen B. [S3 guidelines on bipolar disorders are contemporary and important instruments for clinical practice. Against]. Der Nervenarzt. 84: 876-8. PMID 23709049 DOI: 10.1007/s00115-013-3797-5  0.349
2013 Bauer R, Glenn T, Alda M, Sagduyu K, Marsh W, Grof P, Munoz R, Murray G, Ritter P, Lewitzka U, Severus E, Whybrow PC, Bauer M. Antidepressant dosage taken by patients with bipolar disorder: factors associated with irregularity. International Journal of Bipolar Disorders. 1: 26. PMID 25505689 DOI: 10.1186/2194-7511-1-26  0.536
2013 Berghöfer A, Alda M, Adli M, Baethge C, Bauer M, Bschor T, Grof P, Müller-Oerlinghausen B, Rybakowski JK, Suwalska A, Pfennig A. Stability of lithium treatment in bipolar disorder - long-term follow-up of 346 patients. International Journal of Bipolar Disorders. 1: 11. PMID 25505678 DOI: 10.1186/2194-7511-1-11  0.58
2013 Eid L, Heim K, Doucette S, McCloskey S, Duffy A, Grof P. Bipolar disorder and socioeconomic status: what is the nature of this relationship? International Journal of Bipolar Disorders. 1: 9. PMID 25505676 DOI: 10.1186/2194-7511-1-9  0.663
2013 Bauer M, Glenn T, Alda M, Sagduyu K, Marsh W, Grof P, Munoz R, Severus E, Ritter P, Whybrow PC. Drug treatment patterns in bipolar disorder: analysis of long-term self-reported data. International Journal of Bipolar Disorders. 1: 5. PMID 25505672 DOI: 10.1186/2194-7511-1-5  0.479
2013 Alda M, Shao L, Wang JF, Lopez de Lara C, Jaitovich-Groisman I, Lebel V, Sun X, Duffy A, Grof P, Rouleau GA, Turecki G, Young LT. Alterations in phosphorylated cAMP response element-binding protein (pCREB) signaling: an endophenotype of lithium-responsive bipolar disorder? Bipolar Disorders. 15: 824-31. PMID 24238631 DOI: 10.1111/Bdi.12131  0.733
2013 Manchia M, Adli M, Akula N, Ardau R, Aubry JM, Backlund L, Banzato CE, Baune BT, Bellivier F, Bengesser S, Biernacka JM, Brichant-Petitjean C, Bui E, Calkin CV, Cheng AT, ... ... Grof P, et al. Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report. Plos One. 8: e65636. PMID 23840348 DOI: 10.1371/Journal.Pone.0065636  0.755
2013 Bauer M, Glenn T, Alda M, Sagduyu K, Marsh W, Grof P, Munoz R, Baethge C, Lewitzka U, Pilhatsch M, Bauer R, Whybrow PC. Regularity in daily mood stabilizer dosage taken by patients with bipolar disorder. Pharmacopsychiatry. 46: 163-8. PMID 23797414 DOI: 10.1055/s-0033-1343398  0.487
2013 Duffy A, Horrocks J, Doucette S, Keown-Stoneman C, McCloskey S, Grof P. Childhood anxiety: an early predictor of mood disorders in offspring of bipolar parents. Journal of Affective Disorders. 150: 363-9. PMID 23707033 DOI: 10.1016/J.Jad.2013.04.021  0.716
2013 Grof P. Melancholia: a distinct entity? Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie. 58: 181-2. PMID 23547639 DOI: 10.1177/070674371305800401  0.363
2013 Doucette S, Horrocks J, Grof P, Keown-Stoneman C, Duffy A. Attachment and temperament profiles among the offspring of a parent with bipolar disorder. Journal of Affective Disorders. 150: 522-6. PMID 23453672 DOI: 10.1016/J.Jad.2013.01.023  0.697
2013 Grof P. Book Review: Bipolar Disorder: The Bipolar Spectrum. Diagnosis or Fad? The Canadian Journal of Psychiatry. 58: 123-124. DOI: 10.1177/070674371305800210  0.506
2012 Müller-Oerlinghausen B, Bauer M, Grof P. Commentary on a recent review of lithium toxicity: what are its implications for clinical practice? Bmc Medicine. 10: 132. PMID 23121772 DOI: 10.1186/1741-7015-10-132  0.307
2012 Lewitzka U, Doucette S, Seemüller F, Grof P, Duffy AC. Biological indicators of suicide risk in youth with mood disorders: what do we know so far? Current Psychiatry Reports. 14: 705-12. PMID 22996299 DOI: 10.1007/S11920-012-0329-0  0.651
2012 Duffy A, Horrocks J, Milin R, Doucette S, Persson G, Grof P. Adolescent substance use disorder during the early stages of bipolar disorder: a prospective high-risk study. Journal of Affective Disorders. 142: 57-64. PMID 22959686 DOI: 10.1016/J.Jad.2012.04.010  0.709
2012 Bauer M, Glenn T, Keil M, Bauer R, Marsh W, Grof P, Alda M, Sagduyu K, Murray G, Quiroz D, Baethge C, Whybrow PC. Brief depressive symptoms in patients with bipolar disorder: analysis of long-term self-reported data. The Australian and New Zealand Journal of Psychiatry. 46: 1068-78. PMID 22734088 DOI: 10.1177/0004867412452017  0.525
2012 Cruceanu C, Alda M, Grof P, Rouleau GA, Turecki G. Synapsin II is involved in the molecular pathway of lithium treatment in bipolar disorder. Plos One. 7: e32680. PMID 22384280 DOI: 10.1371/Journal.Pone.0032680  0.689
2012 Duffy A, Lewitzka U, Doucette S, Andreazza A, Grof P. Biological indicators of illness risk in offspring of bipolar parents: targeting the hypothalamic-pituitary-adrenal axis and immune system. Early Intervention in Psychiatry. 6: 128-37. PMID 22182213 DOI: 10.1111/J.1751-7893.2011.00323.X  0.647
2012 Grof P. Lithium use for bipolar disorder - does the LiTMUS trial change anything? International Clinical Psychopharmacology. 28: e15. DOI: 10.1097/01.YIC.0000423254.26080.9F  0.375
2011 Hajek T, Alda M, Grof P. Discontinuation of lithium because of side effects. Journal of Psychiatry & Neuroscience : Jpn. 36: E39-40. PMID 22011562 DOI: 10.1503/Jpn.110117  0.661
2011 Duffy A, Doucette S, Lewitzka U, Alda M, Hajek T, Grof P. Findings from bipolar offspring studies: methodology matters. Early Intervention in Psychiatry. 5: 181-91. PMID 21718461 DOI: 10.1111/J.1751-7893.2011.00276.X  0.769
2011 Bauer M, Glenn T, Alda M, Grof P, Sagduyu K, Bauer R, Lewitzka U, Whybrow PC. Comparison of pre-episode and pre-remission states using mood ratings from patients with bipolar disorder. Pharmacopsychiatry. 44: S49-53. PMID 21544745 DOI: 10.1055/S-0031-1273765  0.542
2011 Bauer M, Glenn T, Rasgon N, Marsh W, Sagduyu K, Grof P, Alda M, Murray G, Munoz R, Quiroz D, Bauer R, Jabs B, Whybrow PC. Decreasing the minimum length criterion for an episode of hypomania: evaluation using self-reported data from patients with bipolar disorder. European Archives of Psychiatry and Clinical Neuroscience. 261: 341-7. PMID 21267744 DOI: 10.1007/S00406-010-0187-X  0.587
2010 Grof P. Investigating children at high risk for bipolar and psychotic disorders: findings and implications. Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie. 55: 475-6. PMID 20723274 DOI: 10.1177/070674371005500801  0.525
2010 Lopez de Lara C, Jaitovich-Groisman I, Cruceanu C, Mamdani F, Lebel V, Yerko V, Beck A, Young LT, Rouleau G, Grof P, Alda M, Turecki G. Implication of synapse-related genes in bipolar disorder by linkage and gene expression analyses. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 13: 1397-410. PMID 20667171 DOI: 10.1017/S1461145710000714  0.639
2010 Pfennig A, Schlattmann P, Alda M, Grof P, Glenn T, Müller-Oerlinghausen B, Suwalska A, Rybakowski J, Willich SN, Bauer M, Berghöfer A. Influence of atypical features on the quality of prophylactic effectiveness of long-term lithium treatment in bipolar disorders. Bipolar Disorders. 12: 390-6. PMID 20636636 DOI: 10.1111/J.1399-5618.2010.00826.X  0.619
2010 Duffy A, Grof P, Hajek T, Alda M. Resolving the discrepancy in childhood bipolar high-risk study findings. The American Journal of Psychiatry. 167: 716; author reply 71. PMID 20516164 DOI: 10.1176/Appi.Ajp.2010.10020170  0.746
2010 Schulze TG, Alda M, Adli M, Akula N, Ardau R, Bui ET, Chillotti C, Cichon S, Czerski P, Del Zompo M, Detera-Wadleigh SD, Grof P, Gruber O, Hashimoto R, Hauser J, et al. The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment. Neuropsychobiology. 62: 72-8. PMID 20453537 DOI: 10.1159/000314708  0.796
2010 Grof P. Sixty years of lithium responders. Neuropsychobiology. 62: 8-16. PMID 20453530 DOI: 10.1159/000314305  0.47
2010 Bauer M, Glenn T, Grof P, Marsh W, Sagduyu K, Alda M, Murray G, Lewitzka U, Schmid R, Haack S, Whybrow PC. The association between concurrent psychotropic medications and self-reported adherence with taking a mood stabilizer in bipolar disorder. Human Psychopharmacology. 25: 47-54. PMID 20033908 DOI: 10.1002/Hup.1077  0.522
2010 Bauer M, Glenn T, Grof P, Schmid R, Pfennig A, Whybrow PC. Subsyndromal mood symptoms: a useful concept for maintenance studies of bipolar disorder? Psychopathology. 43: 1-7. PMID 19893338 DOI: 10.1159/000255957  0.468
2010 Duffy A, Alda M, Hajek T, Sherry SB, Grof P. Early stages in the development of bipolar disorder. Journal of Affective Disorders. 121: 127-35. PMID 19541368 DOI: 10.1016/J.Jad.2009.05.022  0.812
2009 Bauer M, Glenn T, Grof P, Rasgon NL, Marsh W, Sagduyu K, Alda M, Lewitzka U, Schmid R, Whybrow PC. Relationship between adjunctive medications for anxiety and time spent ill in patients with bipolar disorder. International Journal of Psychiatry in Clinical Practice. 13: 70-7. PMID 24946124 DOI: 10.1080/13651500802450514  0.619
2009 Duffy A, Alda M, Hajek T, Grof P. Early course of bipolar disorder in high-risk offspring: prospective study. The British Journal of Psychiatry : the Journal of Mental Science. 195: 457-8. PMID 19880938 DOI: 10.1192/Bjp.Bp.108.062810  0.809
2009 Grof P, Duffy A, Alda M, Hajek T. Lithium response across generations. Acta Psychiatrica Scandinavica. 120: 378-85. PMID 19807719 DOI: 10.1111/J.1600-0447.2009.01454.X  0.779
2009 Grof P, Müller-Oerlinghausen B. A critical appraisal of lithium's efficacy and effectiveness: the last 60 years. Bipolar Disorders. 11: 10-9. PMID 19538682 DOI: 10.1111/J.1399-5618.2009.00707.X  0.444
2009 Duffy A, Hajek T, Alda M, Grof P, Milin R, MacQueen G. Neurocognitive functioning in the early stages of bipolar disorder: visual backward masking performance in high risk subjects. European Archives of Psychiatry and Clinical Neuroscience. 259: 263-9. PMID 19390766 DOI: 10.1007/S00406-008-0862-3  0.785
2009 Duffy A, Milin R, Grof P. Maintenance treatment of adolescent bipolar disorder: open study of the effectiveness and tolerability of quetiapine. Bmc Psychiatry. 9: 4. PMID 19200370 DOI: 10.1186/1471-244X-9-4  0.682
2009 Bauer M, Glenn T, Grof P, Rasgon N, Alda M, Marsh W, Sagduyu K, Schmid R, Adli M, Whybrow PC. Comparison of sleep/wake parameters for self-monitoring bipolar disorder. Journal of Affective Disorders. 116: 170-5. PMID 19118904 DOI: 10.1016/J.Jad.2008.11.014  0.449
2009 Bauer M, Glenn T, Grof P, Rasgon NL, Marsh W, Sagduyu K, Alda M, Murray G, Quiroz D, Malliaris Y, Sasse J, Pilhatsch M, Whybrow PC. Relationship among latitude, climate, season and self-reported mood in bipolar disorder. Journal of Affective Disorders. 116: 152-7. PMID 19091424 DOI: 10.1016/J.Jad.2008.11.013  0.577
2009 Bauer M, Glenn T, Grof P, Rasgon NL, Marsh W, Sagduyu K, Alda M, Lewitzka U, Sasse J, Kozuch-Krolik E, Whybrow PC. Frequency of subsyndromal symptoms and employment status in patients with bipolar disorder. Social Psychiatry and Psychiatric Epidemiology. 44: 515-22. PMID 19011720 DOI: 10.1007/S00127-008-0464-4  0.551
2009 Grof P. Book Review: Bipolar II Disorder: Modelling, Measuring and Managing The Canadian Journal of Psychiatry. 54: 67-68. DOI: 10.1177/070674370905400112  0.416
2008 Berghöfer A, Alda M, Adli M, Baethge C, Bauer M, Bschor T, Glenn T, Grof P, Müller-Oerlinghausen B, Rybakowski J, Suwalska A, Pfennig A. Long-term effectiveness of lithium in bipolar disorder: a multicenter investigation of patients with typical and atypical features. The Journal of Clinical Psychiatry. 69: 1860-8. PMID 19026269 DOI: 10.4088/Jcp.V69N1203  0.59
2008 Tseng M, Alda M, Xu L, Sun X, Wang JF, Grof P, Turecki G, Rouleau G, Young LT. BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder. Journal of Psychiatry & Neuroscience : Jpn. 33: 449-53. PMID 18787660  0.621
2008 Bauer M, Wilson T, Neuhaus K, Sasse J, Pfennig A, Lewitzka U, Grof P, Glenn T, Rasgon N, Bschor T, Whybrow PC. Self-reporting software for bipolar disorder: validation of ChronoRecord by patients with mania. Psychiatry Research. 159: 359-66. PMID 18423616 DOI: 10.1016/J.Psychres.2007.04.013  0.374
2008 Bauer M, Glenn T, Whybrow PC, Grof P, Rasgon N, Alda M, Marsh W, Sagduyu K, Schmid R, Adli M. Changes in self-reported sleep duration predict mood changes in bipolar disorder. Psychological Medicine. 38: 1069-71. PMID 18377675 DOI: 10.1017/S0033291708003280  0.544
2008 Mamdani F, Alda M, Grof P, Young LT, Rouleau G, Turecki G. Lithium response and genetic variation in the CREB family of genes. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 147: 500-4. PMID 18189280 DOI: 10.1002/Ajmg.B.30617  0.666
2008 Hajek T, Gunde E, Bernier D, Slaney C, Propper L, Grof P, Macqueen G, Duffy A, Alda M. Subgenual cingulate volumes in affected and unaffected offspring of bipolar parents. Journal of Affective Disorders. 108: 263-9. PMID 18037495 DOI: 10.1016/J.Jad.2007.10.024  0.787
2008 Grof P. Book Review: Clinical Skills: Psychiatric Clinical SkillsClinical Skills Psychiatric Clinical SkillsGoldbloomDavid S. Toronto (ON): Elsevier Canada; 2006. 408 p. CDN$66.95. The Canadian Journal of Psychiatry. 53: 131-132. DOI: 10.1177/070674370805300211  0.304
2007 Duffy A, Alda M, Crawford L, Milin R, Grof P. The early manifestations of bipolar disorder: a longitudinal prospective study of the offspring of bipolar parents. Bipolar Disorders. 9: 828-38. PMID 18076532 DOI: 10.1111/J.1399-5618.2007.00421.X  0.754
2007 Duffy A, Alda M, Milin R, Grof P. A consecutive series of treated affected offspring of parents with bipolar disorder: is response associated with the clinical profile? Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie. 52: 369-76. PMID 17696023 DOI: 10.1177/070674370705200606  0.765
2007 Cavazzoni P, Grof P, Duffy A, Grof E, Müller-Oerlinghausen B, Berghöfer A, Ahrens B, Zvolsky P, Robertson C, Davis A, Hajek T, Alda M. Heterogeneity of the risk of suicidal behavior in bipolar-spectrum disorders. Bipolar Disorders. 9: 377-85. PMID 17547584 DOI: 10.1111/J.1399-5618.2007.00516.X  0.802
2007 Mamdani F, Sequeira A, Alda M, Grof P, Rouleau G, Turecki G. No association between the PREP gene and lithium responsive bipolar disorder. Bmc Psychiatry. 7: 9. PMID 17324276 DOI: 10.1186/1471-244X-7-9  0.675
2007 Bauer M, Glenn T, Grof P, Pfennig A, Rasgon NL, Marsh W, Munoz RA, Sagduyu K, Alda M, Quiroz D, Sasse J, Whybrow PC. Self-reported data from patients with bipolar disorder: frequency of brief depression. Journal of Affective Disorders. 101: 227-33. PMID 17224186 DOI: 10.1016/J.Jad.2006.11.021  0.531
2007 Duffy A, Alda M, Trinneer A, Demidenko N, Grof P, Goodyer IM. Temperament, life events, and psychopathology among the offspring of bipolar parents. European Child & Adolescent Psychiatry. 16: 222-8. PMID 17136299 DOI: 10.1007/S00787-006-0592-X  0.671
2007 Grof P. Book Review: Bipolar Disorder, Treating Bipolar Disorder: A Clinician's Guide to Interpersonal and Social Rhythm Therapy The Canadian Journal of Psychiatry. 52: 67-68. DOI: 10.1177/070674370705200112  0.484
2006 Glenn T, Whybrow PC, Rasgon N, Grof P, Alda M, Baethge C, Bauer M. Approximate entropy of self-reported mood prior to episodes in bipolar disorder. Bipolar Disorders. 8: 424-9. PMID 17042880 DOI: 10.1111/J.1399-5618.2006.00373.X  0.557
2006 Deshauer D, Duffy A, Meaney M, Sharma S, Grof P. Salivary cortisol secretion in remitted bipolar patients and offspring of bipolar parents. Bipolar Disorders. 8: 345-9. PMID 16879135 DOI: 10.1111/J.1399-5618.2006.00338.X  0.83
2006 Bauer M, Rasgon N, Grof P, Glenn T, Lapp M, Marsh W, Munoz R, Suwalska A, Baethge C, Bschor T, Alda M, Whybrow PC. Do antidepressants influence mood patterns? A naturalistic study in bipolar disorder. European Psychiatry : the Journal of the Association of European Psychiatrists. 21: 262-9. PMID 16782312 DOI: 10.1016/J.Eurpsy.2006.04.009  0.612
2006 Bauer M, Grof P, Rasgon NL, Marsh W, Munoz RA, Sagduyu K, Alda M, Quiroz D, Glenn T, Baethge C, Whybrow PC. Self-reported data from patients with bipolar disorder: impact on minimum episode length for hypomania. Journal of Affective Disorders. 96: 101-5. PMID 16782206 DOI: 10.1016/J.Jad.2006.05.006  0.569
2006 Bauer M, Grof P, Rasgon N, Bschor T, Glenn T, Whybrow PC. Temporal relation between sleep and mood in patients with bipolar disorder. Bipolar Disorders. 8: 160-7. PMID 16542186 DOI: 10.1111/J.1399-5618.2006.00294.X  0.382
2006 Bauer M, Grof P, Rasgon N, Glenn T, Alda M, Priebe S, Ricken R, Whybrow PC. Mood charting and technology: New approach to monitoring patients with mood disorders Current Psychiatry Reviews. 2: 423-429. DOI: 10.2174/157340006778699747  0.607
2006 Deshauer D, Fergusson D, Grof P. Response to Severus, Kleindienst and Greil regarding 'Re-evaluation of randomized controlled trials of lithium monotherapy: a cohort effect' Bipolar Disorders. 8: 521-521. DOI: 10.1111/J.1399-5618.2006.00366.X  0.737
2005 Adli M, Whybrow PC, Grof P, Rasgon N, Gyulai L, Baethge C, Glenn T, Bauer M. Use of polypharmacy and self-reported mood in outpatients with bipolar disorder. International Journal of Psychiatry in Clinical Practice. 9: 251-6. PMID 24930922 DOI: 10.1080/13651500510029200  0.418
2005 Deshauer D, Fergusson D, Duffy A, Albuquerque J, Grof P. Re-evaluation of randomized control trials of lithium monotherapy: a cohort effect. Bipolar Disorders. 7: 382-7. PMID 16026492 DOI: 10.1111/J.1399-5618.2005.00206.X  0.779
2005 Alda M, Grof P, Rouleau GA, Turecki G, Young LT. Investigating responders to lithium prophylaxis as a strategy for mapping susceptibility genes for bipolar disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 1038-45. PMID 15946781 DOI: 10.1016/J.Pnpbp.2005.03.021  0.744
2005 Bauer M, Rasgon N, Grof P, Altshuler L, Gyulai L, Lapp M, Glenn T, Whybrow PC. Mood changes related to antidepressants: a longitudinal study of patients with bipolar disorder in a naturalistic setting. Psychiatry Research. 133: 73-80. PMID 15698679 DOI: 10.1016/J.Psychres.2004.08.006  0.439
2005 Rasgon N, Bauer M, Grof P, Gyulai L, Elman S, Glenn T, Whybrow PC. Sex-specific self-reported mood changes by patients with bipolar disorder. Journal of Psychiatric Research. 39: 77-83. PMID 15504425 DOI: 10.1016/J.Jpsychires.2004.05.006  0.506
2004 MacQueen GM, Grof P, Alda M, Marriott M, Young LT, Duffy A. A pilot study of visual backward masking performance among affected versus unaffected offspring of parents with bipolar disorder. Bipolar Disorders. 6: 374-8. PMID 15383129 DOI: 10.1111/J.1399-5618.2004.00133.X  0.734
2004 Demidenko N, Grof P, Alda M, Deshauer D, Duffy A. MMPI as a measure of subthreshold and residual psychopathology among the offspring of lithium responsive and non-responsive bipolar parents. Bipolar Disorders. 6: 323-8. PMID 15225151 DOI: 10.1111/J.1399-5618.2004.00130.X  0.816
2004 Bauer M, Grof P, Gyulai L, Rasgon N, Glenn T, Whybrow PC. Using technology to improve longitudinal studies: self-reporting with ChronoRecord in bipolar disorder. Bipolar Disorders. 6: 67-74. PMID 14996143 DOI: 10.1046/J.1399-5618.2003.00085.X  0.42
2004 Sun X, Young LT, Wang JF, Grof P, Turecki G, Rouleau GA, Alda M. Identification of lithium-regulated genes in cultured lymphoblasts of lithium responsive subjects with bipolar disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 799-804. PMID 14735134 DOI: 10.1038/Sj.Npp.1300383  0.631
2003 Whybrow PC, Grof P, Gyulai L, Rasgon N, Glenn T, Bauer M. The electronic assessment of the longitudinal course of bipolar disorder: the ChronoRecord software. Pharmacopsychiatry. 36: S244-9. PMID 14677086 DOI: 10.1055/s-2003-45137  0.33
2003 Deshauer D, Duffy A, Alda M, Grof E, Albuquerque J, Grof P. The cortisol awakening response in bipolar illness: a pilot study. Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie. 48: 462-6. PMID 12971016 DOI: 10.1177/070674370304800706  0.789
2003 Albuquerque J, Deshauer D, Grof P. Descartes' Passions of the soul--seeds of psychiatry? Journal of Affective Disorders. 76: 285-91. PMID 12943961 DOI: 10.1016/S0165-0327(02)00104-0  0.715
2003 Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI, Craddock N, DePaulo JR, Baron M, Gershon ES, Ekholm J, Cichon S, Turecki G, Claes S, Kelsoe JR, ... ... Grof P, et al. Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder. American Journal of Human Genetics. 73: 49-62. PMID 12802785 DOI: 10.1086/376547  0.651
2003 Grof P. Selecting effective long-term treatment for bipolar patients: monotherapy and combinations. The Journal of Clinical Psychiatry. 64: 53-61. PMID 12720485  0.307
2003 Baethge C, Smolka MN, Gruschka P, Berghöfer A, Schlattmann P, Bauer M, Altshuler L, Grof P, Müller-Oerlinghausen B. Does prophylaxis-delay in bipolar disorder influence outcome? Results from a long-term study of 147 patients. Acta Psychiatrica Scandinavica. 107: 260-7. PMID 12662248 DOI: 10.1034/J.1600-0447.2003.02057.X  0.434
2003 Alda M, Grof P, Rouleau G, Turecki G, Young L. S.22.04 Neurobiology of treatment response in affective disorders European Neuropsychopharmacology. 13: S155. DOI: 10.1016/S0924-977X(03)91685-3  0.664
2002 Duffy A, Alda M, Kutcher S, Cavazzoni P, Robertson C, Grof E, Grof P. A prospective study of the offspring of bipolar parents responsive and nonresponsive to lithium treatment. The Journal of Clinical Psychiatry. 63: 1171-8. PMID 12523878 DOI: 10.4088/Jcp.V63N1213  0.822
2002 Grof P, Duffy A, Cavazzoni P, Grof E, Garnham J, MacDougall M, O'Donovan C, Alda M. Is response to prophylactic lithium a familial trait? The Journal of Clinical Psychiatry. 63: 942-7. PMID 12416605 DOI: 10.4088/Jcp.V63N1013  0.847
2002 Grof P. Mood disorders--new definitions, treatment directions, and understanding. Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie. 47: 123-4. PMID 11926073 DOI: 10.1177/070674370204700201  0.481
2002 Duffy A, Grof P. Psychiatric diagnoses in the context of genetic studies of bipolar disorder. Bipolar Disorders. 3: 270-5. PMID 11843777 DOI: 10.1034/J.1399-5618.2001.30602.X  0.677
2002 Grof P. Reply: Evidence Supports Validity of Seasonal Affective Disorder The Canadian Journal of Psychiatry. 47: 786-787. DOI: 10.1177/070674370204700819  0.494
2002 Grof P. Book Review: Mood Disorders: Emotions, the Sci ence ofSen ti ment The Canadian Journal of Psychiatry. 47: 187-187. DOI: 10.1177/070674370204700211  0.4
2001 Duffy A, Grof P, Kutcher S, Robertson C, Alda M. Measures of attention and hyperactivity symptoms in a high-risk sample of children of bipolar parents. Journal of Affective Disorders. 67: 159-65. PMID 11869763 DOI: 10.1016/S0165-0327(01)00391-3  0.648
2001 Turecki G, Grof P, Grof E, D'Souza V, Lebuis L, Marineau C, Cavazzoni P, Duffy A, Bétard C, Zvolský P, Robertson C, Brewer C, Hudson TJ, Rouleau GA, Alda M. Mapping susceptibility genes for bipolar disorder: a pharmacogenetic approach based on excellent response to lithium. Molecular Psychiatry. 6: 570-8. PMID 11526471 DOI: 10.1038/Sj.Mp.4000888  0.808
2001 Alda M, Keller D, Grof E, Turecki G, Cavazzoni P, Duffy A, Rouleau GA, Grof P, Young LT. Is lithium response related to G(s)alpha levels in transformed lymphoblasts from subjects with bipolar disorder? Journal of Affective Disorders. 65: 117-22. PMID 11356234 DOI: 10.1016/S0165-0327(00)00166-X  0.816
2001 Ftouhi-Paquin N, Alda M, Grof P, Chretien N, Rouleau G, Turecki G. Identification of three polymorphisms in the translated region of PLC-gamma1 and their investigation in lithium responsive bipolar disorder. American Journal of Medical Genetics. 105: 301-5. PMID 11353454 DOI: 10.1002/Ajmg.1326  0.647
2001 Grof P. Book Review: Genetics of Mental Disorders, a Guide for Students, Clinicians and Researchers The Canadian Journal of Psychiatry. 46: 983-984. DOI: 10.1177/070674370104601014  0.384
2000 Alda M, Grof P, Ravindran L, Cavazzoni P, Duffy A, Grof E, Zvolský P, Wilson J. Anticipation in bipolar affective disorder: is age at onset a valid criterion? American Journal of Medical Genetics. 96: 804-7. PMID 11121186 DOI: 10.1002/1096-8628(20001204)96:6<804::Aid-Ajmg22>3.0.Co;2-T  0.8
2000 Grof P, Robbins W, Alda M, Berghoefer A, Vojtechovsky M, Nilsson A, Robertson C. Protective effect of pregnancy in women with lithium-responsive bipolar disorder. Journal of Affective Disorders. 61: 31-9. PMID 11099738 DOI: 10.1016/S0165-0327(99)00197-4  0.603
2000 Duffy A, Grof P, Robertson C, Alda M. The implications of genetics studies of major mood disorders for clinical practice. The Journal of Clinical Psychiatry. 61: 630-7. PMID 11030482 DOI: 10.4088/Jcp.V61N0906  0.732
2000 Alda M, Turecki G, Grof P, Cavazzoni P, Duffy A, Grof E, Ahrens B, Berghöfer A, Müller-Oerlinghausen B, Dvoráková M, Libigerová E, VojtÄ•chovský M, Zvolský P, Joober R, Nilsson A, et al. Association and linkage studies of CRH and PENK genes in bipolar disorder: a collaborative IGSLI study. American Journal of Medical Genetics. 96: 178-81. PMID 10893493 DOI: 10.1002/(Sici)1096-8628(20000403)96:2<178::Aid-Ajmg11>3.0.Co;2-C  0.836
2000 Deshauer D, Albuquerque J, Alda M, Grof P. Seizures caused by possible interaction between olanzapine and clomipramine. Journal of Clinical Psychopharmacology. 20: 283-4. PMID 10770480 DOI: 10.1097/00004714-200004000-00034  0.74
2000 Turecki G, Alda M, Grof P, Joober R, Lafrenière R, Cavazzoni P, Duffy A, Grof E, Ahrens B, Berghöfer A, Müller-Oerlinghausen B, Dvoráková M, Libigerová E, Vojtechovský M, Zvolský P, et al. Polyglutamine coding genes in bipolar disorder: lack of association with selected candidate loci. Journal of Affective Disorders. 58: 63-8. PMID 10760559 DOI: 10.1016/S0165-0327(99)00074-9  0.823
2000 Grof P, Alda M. Discrepancies in the efficacy of lithium. Archives of General Psychiatry. 57: 191. PMID 10665623 DOI: 10.1001/Archpsyc.57.2.191  0.459
2000 Cavazzoni P, Ahrens B, Berghöfer A, Duffy A, Grof E, Müller-Oerlinghausen B, Zvolský P, Grof P, Alda M. P02.239 Family study of suicidal behaviour in bipolar disorder European Psychiatry. 15: 386s-386s. DOI: 10.1016/S0924-9338(00)94647-9  0.826
2000 Alda M, Zvolský P, Grof P. S31.04 Search for genes for bipolar disorder: The Czech-Canadian connection European Psychiatry. 15: 277s-277s. DOI: 10.1016/S0924-9338(00)94206-8  0.813
2000 Turecki G, Grof P, Grof E, D’Souza V, Cavazzoni P, Duffy A, Brewer C, Hudson T, Rouleau G, Alda M. 228. A genome scan using a pharmacogenetic approach indicates a susceptibility locus for BD on 15q14 Biological Psychiatry. 47: S69-S70. DOI: 10.1016/S0006-3223(00)00492-3  0.767
1999 Turecki G, Grof P, Cavazzoni P, Duffy A, Grof E, Martin R, Joober R, Rouleau GA, Alda M. Lithium responsive bipolar disorder, unilineality, and chromosome 18: A linkage study. American Journal of Medical Genetics. 88: 411-5. PMID 10402510 DOI: 10.1002/(Sici)1096-8628(19990820)88:4<411::Aid-Ajmg20>3.0.Co;2-9  0.818
1999 Turecki G, Alda M, Grof P, Joober R, Cavazzoni P, Duffy A, Grof E, Ahrens B, Berghöfer A, Müller-Oerlinghausen B, Dvoráková M, Libigerová E, Vojtechovský M, Zvolský P, Nilsson A, et al. Polyglutamine tracts: no evidence of a major role in bipolar disorder. Molecular Psychiatry. 4: 220-1. PMID 10395210 DOI: 10.1038/Sj.Mp.4000539  0.845
1999 Alda M, Cavazzoni P, Grof P. Treatment response to prophylactic lithium and family history of psychiatric disorders. Biological Psychiatry. 45: 1078. PMID 10386197 DOI: 10.1016/S0006-3223(98)00314-X  0.784
1999 Deshauer D, Grof E, Alda M, Grof P. Patterns of DST positivity in remitted affective disorders. Biological Psychiatry. 45: 1023-9. PMID 10386185 DOI: 10.1016/S0006-3223(98)00334-5  0.82
1999 Turecki G, Grof P, Cavazzoni P, Duffy A, Grof E, Ahrens B, Berghöfer A, Müller-Oerlinghausen B, Dvoráková M, Libigerová E, Vojtechovsky M, Zvolsky P, Joober R, Nilsson A, Prochazka H, et al. MAOA: association and linkage studies with lithium responsive bipolar disorder. Psychiatric Genetics. 9: 13-6. PMID 10335547 DOI: 10.1097/00041444-199903000-00003  0.858
1998 Duffy A, Grof P, Grof E, Zvolsky P, Alda M. Evidence supporting the independent inheritance of primary affective disorders and primary alcoholism in the families of bipolar patients. Journal of Affective Disorders. 50: 91-6. PMID 9858068 DOI: 10.1016/S0165-0327(98)00017-2  0.824
1998 Turecki G, Grof P, Cavazzoni P, Duffy A, Grof E, Ahrens B, Berghöfer A, Müller-Oerlinghausen B, Dvoráková M, Libigerová E, Vojtechovský M, Zvolský P, Joober R, Nilsson A, Prochazka H, et al. Evidence for a role of phospholipase C-gamma1 in the pathogenesis of bipolar disorder. Molecular Psychiatry. 3: 534-8. PMID 9857980 DOI: 10.1038/Sj.Mp.4000447  0.845
1998 Alda M, Grof P, Grof E. MN blood groups and bipolar disorder: evidence of genotypic association and Hardy-Weinberg disequilibrium. Biological Psychiatry. 44: 361-3. PMID 9755358 DOI: 10.1016/S0006-3223(98)00013-4  0.582
1998 Grof P. Has the effectiveness of lithium changed? Impact of the variety of lithium's effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 19: 183-8. PMID 9653705 DOI: 10.1016/S0893-133X(98)00023-2  0.531
1998 Duffy A, Alda M, Kutcher S, Fusee C, Grof P. Psychiatric symptoms and syndromes among adolescent children of parents with lithium-responsive or lithium-nonresponsive bipolar disorder. The American Journal of Psychiatry. 155: 431-3. PMID 9501760 DOI: 10.1176/Ajp.155.3.431  0.731
1997 Alda M, Grof E, Cavazzoni P, Duffy A, Martin R, Ravindran L, Grof P. Autosomal recessive inheritance of affective disorders in families of responders to lithium prophylaxis? Journal of Affective Disorders. 44: 153-7. PMID 9241575 DOI: 10.1016/S0165-0327(97)00042-6  0.804
1997 Grof P. Affective disorders: discovery and recovery. Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie. 42: 461-2. PMID 9220108 DOI: 10.1177/070674379704200501  0.511
1997 Grof P. The age of misery: affective disorders on the rise. Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie. 42: 361-2. PMID 9161760 DOI: 10.1177/070674379704200401  0.459
1997 Müller-Oerlinghausen B, Wolf T, Ahrens B, Glaenz T, Schou M, Grof E, Grof P, Lenz G, Simhandl C, Thau K, Vestergaard P, Wolf R. Mortality of patients who dropped out from regular lithium prophylaxis: a collaborative study by the International Group for the Study of Lithium-treated patients (IGSLI). Acta Psychiatrica Scandinavica. 94: 344-7. PMID 9124081 DOI: 10.1111/J.1600-0447.1996.Tb09870.X  0.374
1997 Grof P. Book Review: Affective Disorders: Treating Depression The Canadian Journal of Psychiatry. 42: 1079-1079. DOI: 10.1177/070674379704201013  0.423
1997 Alda M, Turceki G, Grof P, Ahrens B, Berghoffer A, Cavazzoni P, Duffy A, Dvor̆áková M, Grof E, Holzinger A, Joober R, Libigerová E, Licht R, Martin R, Müller-Oerlinghausen B, et al. P.1.134 Molecular genetic investigations of candidate loci in lithium responsive bipolar disorder — A study by IGSLI European Neuropsychopharmacology. 7: S177. DOI: 10.1016/S0924-977X(97)88583-5  0.83
1997 Duffy A, Alda M, Fusee C, Kutcher S, Grof P. The early course of illness among adolescent children of parents with bipolar disorder Biological Psychiatry. 42: 250S. DOI: 10.1016/S0006-3223(97)87949-8  0.711
1997 Alda M, Turecki G, Cavazzoni P, Duffy A, Grof E, Martin R, Rouleau G, Grof P. Genetic linkage and association studies of candidate loci in lithium-responsive bipolar disorder Biological Psychiatry. 42: 208S. DOI: 10.1016/S0006-3223(97)87765-7  0.851
1996 Cavazzoni P, Alda M, Turecki G, Rouleau G, Grof E, Martin R, Duffy A, Grof P. Lithium-responsive affective disorders: no association with the tyrosine hydroxylase gene. Psychiatry Research. 64: 91-6. PMID 8912950 DOI: 10.1016/0165-1781(96)02888-0  0.847
1996 Turecki G, Alda M, Grof P, Martin R, Cavazzoni PA, Duffy A, Maciel P, Rouleau GA. No association between chromosome-18 markers and lithium-responsive affective disorders. Psychiatry Research. 63: 17-23. PMID 8832770 DOI: 10.1016/0165-1781(96)02864-8  0.646
1996 Wolf T, Müller-Oerlinghausen B, Ahrens B, Grof P, Schou M, Felber W, Grof E, Lenz G, Nilsson A, Simhandl C, Thau K, Vestergaard P, Wolf R. How to interpret findings on mortality of long-term lithium treated manic-depressive patients?! Critique of different methodological approaches. Journal of Affective Disorders. 39: 127-32. PMID 8827422 DOI: 10.1016/0165-0327(96)00032-8  0.317
1996 Turecki G, Alda M, Grof P, Martin R, Pavazzoni P, Duffy A, Grof E, Rouleau G. Neurotrophic factors and lithium responsive bipolar disorder Psychiatric Genetics. 6: 175. DOI: 10.1097/00041444-199623000-00110  0.792
1996 Ravindran L, Alda M, Grof P, Grof E, Cavazzoni P, Duffy A, Martin R. Age of onset in primary affective disorders: Epidemiological and genetic studies European Neuropsychopharmacology. 6: 251. DOI: 10.1016/0924-977X(96)88403-3  0.558
1996 Kayindran L, Alda M, Grof P, Grof E, Cavazzoni P, Duffy A, Martin R. Age of onset in primary affective disorders: Epidemiological and genetic studies European Neuropsychopharmacology. 6: 215. DOI: 10.1016/0924-977X(96)88312-X  0.813
1996 Zvolský P, Grof P, Alda M, Dvorakova M. History and progress of lithium treatment in Czech Republic/former Czechoslovakia/ European Neuropsychopharmacology. 6: 214. DOI: 10.1016/0924-977X(96)88310-6  0.417
1996 Turecki G, Alda M, Grof P, Grof E, Martin R, Cavazzoni P, Duffy A, Rouleau G. Genetic association studies in lithium responsive affective disorder European Neuropsychopharmacology. 6: 214. DOI: 10.1016/0924-977X(96)88308-8  0.846
1995 Grof P, Alda M, Ahrens B. Clinical course of affective disorders: were Emil Kraepelin and Jules Angst wrong? Psychopathology. 28: 73-80. PMID 8903893 DOI: 10.1159/000284960  0.633
1995 Müller-Oerlinghausen B, Wolf T, Ahrens B, Schou M, Grof E, Grof P, Lenz G, Simhandl C, Thau K, Wolf R. Mortality during initial and during later lithium treatment. A collaborative study by the International Group for the Study of Lithium-treated Patients. Acta Psychiatrica Scandinavica. 90: 295-7. PMID 7832001 DOI: 10.1111/J.1600-0447.1994.Tb01596.X  0.329
1995 Ahrens B, Müller-Oerlinghausen B, Schou M, Wolf T, Alda M, Grof E, Grof P, Lenz G, Simhandl C, Thau K. Excess cardiovascular and suicide mortality of affective disorders may be reduced by lithium prophylaxis. Journal of Affective Disorders. 33: 67-75. PMID 7759663 DOI: 10.1016/0165-0327(94)00074-J  0.532
1995 Ahrens B, Grof P, Möller HJ, Müller-Oerlinghausen B, Wolf T. Extended survival of patients on long-term lithium treatment. Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie. 40: 241-6. PMID 7553542 DOI: 10.1177/070674379504000504  0.351
1995 Winokur G, Scharfetter C, Stassen HH, Baumann U, Sartorius N, Üstün TB, Häfner H, Fätkenheuer B, Nowotny B, Heiden Wad, Merikangas KR, Maier W, Minges J, Lichtermann D, Franke P, ... ... Grof P, et al. Contents, Vol. 28, Supplement 1, 1995 Psychopathology. 28. DOI: 10.1159/000284953  0.399
1994 Grof P. Designing long-term clinical trials in affective disorders. Journal of Affective Disorders. 30: 243-55. PMID 8014324 DOI: 10.1016/0165-0327(94)90132-5  0.35
1994 Alda M, Grof P, Grof E, Zvolsky P, Walsh M. Mode of inheritance in families of patients with lithium-responsive affective disorders. Acta Psychiatrica Scandinavica. 90: 304-10. PMID 7832003 DOI: 10.1111/J.1600-0447.1994.Tb01598.X  0.823
1994 Grof P, Alda M, Grof E, Zvolsky P, Walsh M. Lithium response and genetics of affective disorders. Journal of Affective Disorders. 32: 85-95. PMID 7829768 DOI: 10.1016/0165-0327(94)90066-3  0.83
1993 Grof P, Alda M, Grof E, Fox D, Cameron P. The challenge of predicting response to stabilising lithium treatment. The importance of patient selection. The British Journal of Psychiatry. Supplement. 16-9. PMID 8217062  0.545
1993 Ahrens B, Müller-Oerlinghausen B, Grof P. Length of Lithium Treatment Needed to Eliminate the High Mortality of Affective Disorders British Journal of Psychiatry. 163: 27-29. DOI: 10.1192/S0007125000292453  0.467
1992 Müller-Oerlinghausen B, Ahrens B, Grof E, Grof P, Lenz G, Schou M, Simhandl C, Thau K, Volk J, Wolf R. The effect of long-term lithium treatment on the mortality of patients with manic-depressive and schizoaffective illness. Acta Psychiatrica Scandinavica. 86: 218-22. PMID 1414416 DOI: 10.1111/J.1600-0447.1992.Tb03255.X  0.301
1986 Grof E, Brown GM, Grof P, Van Loon GR. Effects of lithium administration on plasma catecholamines Psychiatry Research. 19: 87-92. PMID 3538108 DOI: 10.1016/0165-1781(86)90095-8  0.358
1985 Werstiuk ES, Rathbone MP, Grof P. Erythrocyte lithium transport in bipolar affective disorders. The effect of membrane transport inhibitors. Neuropsychobiology. 12: 86-92. PMID 6098856 DOI: 10.1159/000118115  0.438
1984 Grof P, Hux M, Grof E, Arato M. Prediction of response to stabilizing lithium treatment. Pharmacopsychiatria. 16: 195-200. PMID 6665029 DOI: 10.1097/00004714-198408000-00028  0.514
1984 Grof E, Brown GM, Grof P. Neuroendocrine strategies in affective disorders. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 7: 557-62. PMID 6420843 DOI: 10.1016/0278-5846(83)90025-8  0.332
1983 Zvolsky P, Dvorakova M, Grof P. Genealogic study of patients with admission diagnosis of functional psychosis. Archiv Fur Psychiatrie Und Nervenkrankheiten. 232: 157-66. PMID 7159203 DOI: 10.1007/Bf00343696  0.79
1982 Zvolsky P, Jansky L, Vyskocilova J, Grof P. Effects of psychotropic drugs on hamster hibernation-pilot study. Progress in Neuro-Psychopharmacology. 5: 599-602. PMID 7200251 DOI: 10.1016/0364-7722(81)90055-2  0.659
1980 Grof E, Brown GM, Grof P, Finkelberg F. Depression and Hormones. An Outline and Some Perspectives International Journal of Mental Health. 9: 67-90. DOI: 10.1080/00207411.1980.11448863  0.406
1979 Grof P, Angst J, Karasek M, Keitner G. Patient selection for long-term lithium treatment in clinical practice. Archives of General Psychiatry. 36: 894-7. PMID 110281 DOI: 10.1001/Archpsyc.1979.01780080068016  0.326
1971 GROF P, FOLEY P. The Superiority of Lithium Over Methysergide in Treating Manic Patients American Journal of Psychiatry. 127: 1573-a-1574. DOI: 10.1176/Ajp.127.11.1573-A  0.302
1970 Schou M, Baastrup PC, Grof P, Weis P, Angst J. Pharmacological and clinical problems of lithium prophylaxis. The British Journal of Psychiatry : the Journal of Mental Science. 116: 615-9. PMID 5452362 DOI: 10.1192/Bjp.116.535.615  0.398
1970 Angst J, Weis P, Grof P, Baastrup PC, Schou M. Lithium Prophylaxis in Recurrent Affective Disorders British Journal of Psychiatry. 116: 604-614. PMID 4916293 DOI: 10.1192/Bjp.116.535.604  0.454
1970 Grof P, Schou M, Angst J, Baastrup PC, Weis P. Methodological problems of prophylactic trials in recurrent affective disorders. The British Journal of Psychiatry : the Journal of Mental Science. 116: 599-603. PMID 4916292 DOI: 10.1192/Bjp.116.535.599  0.318
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