Lewis C. Cantley, Ph.D.
Affiliations: | Systems Biology | Harvard University, Cambridge, MA, United States |
Area:
PI3K and cancer metabolismWebsite:
http://www.fas.harvard.edu/~biophys/Lewis_Cantley.htmGoogle:
"Lewis C. Cantley"Bio:
http://sysbio.med.harvard.edu/faculty/cantley/
http://cantley.hms.harvard.edu/
http://www.pnas.org/content/101/10/3327.full
Cross-listing: Chemistry Tree - Evolution Tree
Parents
Sign in to add mentor| Gordon G. Hammes | grad student | 1975 | Cornell (Chemistry Tree) | |
| (Characterization of effector binding sites on the coupling factors of oxidative phosphorylation and photophosphorylation) | ||||
| Guido Guidotti | post-doc | 1978 | Harvard (Chemistry Tree) | |
Children
Sign in to add trainee| Daniel Avery Pollard | research assistant | 1998-2001 | Harvard Medical School (Evolution Tree) |
| Seth J. Field | grad student | ||
| Bryan Ngo | grad student | Weil Cornell Medical College (Chemistry Tree) | |
| Claudine M. Yballe | grad student | 2000 | Harvard (Chemistry Tree) |
| Katja A. Lamia | grad student | 2003 | Harvard (Chemistry Tree) |
| Andrew E. Elia | grad student | 2005 | Harvard (Chemistry Tree) |
| Ji Luo | grad student | 2006 | Harvard (Chemistry Tree) |
| Tina L. Yuan | grad student | 2010 | Harvard (Chemistry Tree) |
| Cynthia V. Clower | grad student | 2011 | Harvard (Chemistry Tree) |
| Peiling Tsou | grad student | 2011 | Harvard (Chemistry Tree) |
| Shyh C. Ng | grad student | 2013 | Harvard (Chemistry Tree) |
| Kevin D. Courtney | post-doc | Dana-Farber Cancer Institute (Neurotree) | |
| Alex Toker | post-doc | ||
| Benjamin Turk | post-doc | Harvard Medical School (Chemistry Tree) | |
| Matthew G. Vander Heiden | post-doc | Harvard Medical School (Chemistry Tree) | |
| Orion D. Weiner | post-doc | (Neurotree) | |
| Jihye Yun | post-doc | Weill Cornell Medical College (Chemistry Tree) | |
| Michael B. Yaffe | post-doc | 1996-1998 | Harvard Medical School (Chemistry Tree) |
| Bin Zheng | post-doc | 2003-2010 | (Neurotree) |
| Jason W. Locasale | post-doc | 2008-2012 | Harvard Medical School, Boston, USA |
| Gina M DeNicola | post-doc | 2010-2015 | Harvard Medical School - Beth Israel Deaconess Medical Center (Chemistry Tree) |
| Costas Lyssiotis | post-doc | 2010-2015 | Harvard Medical School (Chemistry Tree) |
| Marcus DaSilva Goncalves | post-doc | 2014-2018 | Weill Cornell Medicine (Neurotree) |
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Publications
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| Gattu AK, Tanzer M, Yaron-Barir TM, et al. (2025) Cell-intrinsic insulin signaling defects in human iPS cell-derived hepatocytes in type 2 diabetes. The Journal of Clinical Investigation. 135 |
| Hillis AL, Tamir T, Perry GE, et al. (2024) Parallel phosphoproteomics and metabolomics map the global metabolic tyrosine phosphoproteome. Proceedings of the National Academy of Sciences of the United States of America. 121: e2413837121 |
| Klomp JE, Diehl JN, Klomp JA, et al. (2024) Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer. Science (New York, N.Y.). 384: eadk0850 |
| Alektiar JM, Shan M, Radyk MD, et al. (2024) Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions. Plos One. 19: e0303577 |
| Yaron-Barir TM, Joughin BA, Huntsman EM, et al. (2024) The intrinsic substrate specificity of the human tyrosine kinome. Nature |
| Rogava M, Aprati TJ, Chi WY, et al. (2024) Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature Cancer |
| Lin TY, Ramsamooj S, Perrier T, et al. (2023) Epinephrine inhibits PI3Kα via the Hippo kinases. Cell Reports. 42: 113535 |
| Ferrarone JR, Thomas J, Unni AM, et al. (2023) LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase. Biorxiv : the Preprint Server For Biology |
| Darabedian N, Ji W, Fan M, et al. (2023) Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor. Nature Chemical Biology |
| Stein BD, Ferrarone JR, Gardner EE, et al. (2023) LKB1-dependent regulation of TPI1 creates a divergent metabolic liability between human and mouse lung adenocarcinoma. Cancer Discovery |