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David Sinclair - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Genetics, Molecular Biology, Microbiology Biology
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Year Citation  Score
2024 Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, ... ... Sinclair DA, et al. Loss of epigenetic information as a cause of mammalian aging. Cell. 187: 1312-1313. PMID 38428398 DOI: 10.1016/j.cell.2024.01.049  0.694
2024 Griffin PT, Kane AE, Trapp A, Li J, Arnold M, Poganik JR, Conway RJ, McNamara MS, Meer MV, Hoffman N, Amorim JA, Tian X, MacArthur MR, Mitchell SJ, Mueller AL, ... ... Sinclair DA, et al. TIME-seq reduces time and cost of DNA methylation measurement for epigenetic clock construction. Nature Aging. PMID 38200273 DOI: 10.1038/s43587-023-00555-2  0.469
2023 Guarente L, Sinclair DA, Kroemer G. Human trials exploring anti-aging medicines. Cell Metabolism. PMID 38181790 DOI: 10.1016/j.cmet.2023.12.007  0.469
2023 Lu YR, Tian X, Sinclair DA. The Information Theory of Aging. Nature Aging. 3: 1486-1499. PMID 38102202 DOI: 10.1038/s43587-023-00527-6  0.513
2023 Tian X, Sinclair DA. Restricting mealtime ameliorates neurodegeneration. Cell Metabolism. 35: 1673-1674. PMID 37793341 DOI: 10.1016/j.cmet.2023.09.006  0.436
2023 Yang JH, Petty CA, Dixon-McDougall T, Lopez MV, Tyshkovskiy A, Maybury-Lewis S, Tian X, Ibrahim N, Chen Z, Griffin PT, Arnold M, Li J, Martinez OA, Behn A, Rogers-Hammond R, ... ... Sinclair DA, et al. Chemically induced reprogramming to reverse cellular aging. Aging. 15. PMID 37437248 DOI: 10.18632/aging.204896  0.546
2023 Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, ... ... Sinclair DA, et al. Loss of epigenetic information as a cause of mammalian aging. Cell. PMID 36638792 DOI: 10.1016/j.cell.2022.12.027  0.713
2022 Amorim JA, Coppotelli G, Rolo AP, Palmeira CM, Ross JM, Sinclair DA. Mitochondrial and metabolic dysfunction in ageing and age-related diseases. Nature Reviews. Endocrinology. PMID 35145250 DOI: 10.1038/s41574-021-00626-7  0.541
2022 Meron E, Thaysen M, Angeli S, Antebi A, Barzilai N, Baur JA, Bekker-Jensen S, Birkisdottir M, Bischof E, Bruening J, Brunet A, Buchwalter A, Cabreiro F, Cai S, Chen BH, ... ... Sinclair DA, et al. Meeting Report: Aging Research and Drug Discovery. Aging. 14. PMID 35089871 DOI: 10.18632/aging.203859  0.504
2020 Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, ... ... Sinclair DA, et al. ARDD 2020: from aging mechanisms to interventions. Aging. 12. PMID 33378272 DOI: 10.18632/aging.202454  0.677
2020 Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, ... ... Sinclair DA, et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 588: 124-129. PMID 33268865 DOI: 10.1038/s41586-020-2975-4  0.488
2019 Ross JM, Coppotelli G, Branca RM, Kim KM, Lehtiö J, Sinclair DA, Olson L. Voluntary exercise normalizes the proteomic landscape in muscle and brain and improves the phenotype of progeroid mice. Aging Cell. e13029. PMID 31489782 DOI: 10.1111/Acel.13029  0.59
2019 Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biology. 24: 101192. PMID 31015147 DOI: 10.1016/j.redox.2019.101192  0.339
2019 Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, ... ... Sinclair DA, et al. Impairment of an Endothelial NAD-HS Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 176: 944-945. PMID 30735637 DOI: 10.1016/j.cell.2019.01.026  0.429
2019 Kane A, Schultz MB, Mitchell S, MacArthur M, Mitchell J, Howlett SE, Bonkowski MS, Sinclair D. MACHINE LEARNING ANALYSIS OF MOUSE FRAILTY FOR PREDICTION OF BIOLOGICAL AGE AND LIFE EXPECTANCY Innovation in Aging. 3: S903-S903. DOI: 10.1093/Geroni/Igz038.3299  0.342
2018 Vatner DE, Zhang J, Oydanich M, Guers J, Katsyuba E, Yan L, Sinclair D, Auwerx J, Vatner SF. Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14. Aging Cell. e12751. PMID 29654651 DOI: 10.1111/Acel.12751  0.339
2018 Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, ... ... Sinclair DA, et al. Impairment of an Endothelial NAD-HS Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 173: 74-89.e20. PMID 29570999 DOI: 10.1016/j.cell.2018.02.008  0.48
2018 Griffin P, Yang J, Rajman L, Sinclair D. Investigating The Dna Damage Response As A Driver Of Epigenetic Change During Aging Innovation in Aging. 2: 883-883. DOI: 10.1093/Geroni/Igy031.3296  0.305
2018 Lu Y, Yu D, Bonkowski M, Schultz M, Tian X, Yang J, He Z, Sinclair D. In Vivo Cellular Reprogramming For Tissue Regeneration And Age Reversal Innovation in Aging. 2: 883-883. DOI: 10.1093/Geroni/Igy031.3294  0.301
2018 Amorim J, Tackur S, Bonkowski M, Rolo A, Palmeira C, Sinclair D. A New Mouse Model To Unravel The Mechanism Of Sirt1 Activation Innovation in Aging. 2: 878-878. DOI: 10.1093/Geroni/Igy031.3277  0.397
2018 Bonkowski M, Shawn D, Lu Y, Schultz M, Reyes J, Guarente L, Sinclair D. DIVERGENT REGULATION OF SIRT1 MEDIATES THE ENDOCRINE RESPONSE TO CALORIE RESTRICTION Innovation in Aging. 2: 88-89. DOI: 10.1093/Geroni/Igy023.337  0.303
2018 Schultz MB, Bochaton T, Bonkowski M, Li J, Lokitiyakul D, Colville A, Gomes A, Sinclair D. Nad+ Depletion As A Cause Of Inflammaging Innovation in Aging. 2: 746-746. DOI: 10.1093/Geroni/Igy023.2751  0.362
2018 Ross JM, Coppotelli G, Amorim J, Hillstedt E, Potts E, Sinclair D. DISRUPTING THE EPIGENOME IN NOVEL NICE MICE TO STUDY AGE-RELATED COGNITIVE DECLINE Innovation in Aging. 2: 626-626. DOI: 10.1093/Geroni/Igy023.2333  0.524
2018 Coppotelli G, Ross J, Ling A, Kim K, Sinclair D. CPNE2: A NEW REGULATOR OF LYSOSOMAL-MITOCHONDRIAL FUNCTION INVOLVED IN AGING AND DISEASE Innovation in Aging. 2: 387-388. DOI: 10.1093/Geroni/Igy023.1445  0.566
2018 Ross JM, Coppotelli G, Branca R, Lehtiö J, Sinclair D, Olson L. USING PROTEOMICS TO ELUCIDATE HOW VOLUNTARY EXERCISE COMBATS AGING PHENOTYPES IN MTDNA MUTATOR MICE Innovation in Aging. 2: 334-334. DOI: 10.1093/Geroni/Igy023.1223  0.593
2017 Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. A conserved NAD(+) binding pocket that regulates protein-protein interactions during aging. Science (New York, N.Y.). 355: 1312-1317. PMID 28336669 DOI: 10.1126/Science.Aad8242  0.746
2017 Sinclair D. Nad Precursors As Interventions For Age-Related Diseases And Extending Human Healthspan Innovation in Aging. 1: 11-11. DOI: 10.1093/Geroni/Igx004.037  0.359
2017 Barzilai N, Gorbunova V, Sinclair D. LONG-LIVED ANIMAL MODELS AND HEALTH-SPAN EXTENSION IN STUDIES OF AGING Innovation in Aging. 1: 10-10. DOI: 10.1093/Geroni/Igx004.033  0.547
2016 Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A. JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks. Cell Reports. PMID 27568560 DOI: 10.1016/J.Celrep.2016.08.006  0.734
2016 Dai H, Ellis JL, Sinclair DA, Hubbard BP. Synthesis and Assay of SIRT1-Activating Compounds. Methods in Enzymology. 574: 213-44. PMID 27423864 DOI: 10.1016/Bs.Mie.2016.01.012  0.695
2014 Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK. Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism. Aging Cell. 13: 1075-85. PMID 25257342 DOI: 10.1111/Acel.12273  0.707
2014 Hubbard BP, Sinclair DA. Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends in Pharmacological Sciences. 35: 146-54. PMID 24439680 DOI: 10.1016/J.Tips.2013.12.004  0.701
2014 Sinclair DA, Guarente L. Small-molecule allosteric activators of sirtuins. Annual Review of Pharmacology and Toxicology. 54: 363-80. PMID 24160699 DOI: 10.1146/Annurev-Pharmtox-010611-134657  0.517
2013 Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, ... ... Sinclair DA, et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 155: 1624-38. PMID 24360282 DOI: 10.1016/J.Cell.2013.11.037  0.676
2013 Hubbard BP, Sinclair DA. Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay. Methods in Molecular Biology (Clifton, N.J.). 1077: 167-77. PMID 24014406 DOI: 10.1007/978-1-62703-637-5_11  0.662
2013 Hubbard BP, Loh C, Gomes AP, Li J, Lu Q, Doyle TL, Disch JS, Armour SM, Ellis JL, Vlasuk GP, Sinclair DA. Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism. Cell Cycle (Georgetown, Tex.). 12: 2233-40. PMID 23892437 DOI: 10.4161/Cc.25268  0.791
2013 Biason-Lauber A, Böni-Schnetzler M, Hubbard BP, Bouzakri K, Brunner A, Cavelti-Weder C, Keller C, Meyer-Böni M, Meier DT, Brorsson C, Timper K, Leibowitz G, Patrignani A, Bruggmann R, Boily G, ... ... Sinclair DA, et al. Identification of a SIRT1 mutation in a family with type 1 diabetes. Cell Metabolism. 17: 448-55. PMID 23473037 DOI: 10.1016/J.Cmet.2013.02.001  0.644
2013 Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, ... ... Sinclair DA, et al. Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (New York, N.Y.). 339: 1216-9. PMID 23471411 DOI: 10.1126/Science.1231097  0.783
2013 Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Molecular and Cellular Biology. 33: 1487-502. PMID 23382074 DOI: 10.1128/Mcb.00971-12  0.739
2013 Han J, Hubbard BP, Lee J, Montagna C, Lee HW, Sinclair DA, Suh Y. Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene. Cell Cycle (Georgetown, Tex.). 12: 263-70. PMID 23255128 DOI: 10.4161/Cc.23056  0.691
2013 Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA. Manipulation of a nuclear NAD + salvage pathway delays aging without altering steady-state NAD + levels. Journal of Biological Chemistry. 288: 24160-24160. DOI: 10.1074/jbc.a113.111773  0.77
2012 Sinclair D, Verdin E. The longevity of sirtuins. Cell Reports. 2: 1473-4. PMID 23273894 DOI: 10.1016/J.Celrep.2012.12.004  0.34
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Sinclair DA, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.457
2012 Rascón B, Hubbard BP, Sinclair DA, Amdam GV. The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction. Aging. 4: 499-508. PMID 22868943  0.682
2012 Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, ... ... Sinclair DA, et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metabolism. 15: 675-90. PMID 22560220 DOI: 10.1016/J.Cmet.2012.04.003  0.673
2012 Gomes AP, Duarte FV, Nunes P, Hubbard BP, Teodoro JS, Varela AT, Jones JG, Sinclair DA, Palmeira CM, Rolo AP. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. Biochimica Et Biophysica Acta. 1822: 185-95. PMID 22027215 DOI: 10.1016/J.Bbadis.2011.10.008  0.662
2012 Rimmele P, Bigarella CL, d'Escamard V, Izac B, Sinclair D, Ghaffari S. SIRT1 Deacetylase Is Essential for Hematopoietic Stem Cell Activity Via Regulation of Foxo3. Blood. 120: 2315-2315. DOI: 10.1182/Blood.V120.21.2315.2315  0.334
2012 Liu H, Hubbard B, Sinclair D, Ma J, Sturges M, Armstrong L. Abstract 216: Novel assays for Sirtuin and PARP families utilizing unmodified substrates Cancer Research. 72: 216-216. DOI: 10.1158/1538-7445.Am2012-216  0.689
2011 Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, ... ... Sinclair DA, et al. SRT1720 improves survival and healthspan of obese mice. Scientific Reports. 1: 70. PMID 22355589 DOI: 10.1038/Srep00070  0.704
2011 Beirowski B, Gustin J, Armour SM, Yamamoto H, Viader A, North BJ, Michán S, Baloh RH, Golden JP, Schmidt RE, Sinclair DA, Auwerx J, Milbrandt J. Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proceedings of the National Academy of Sciences of the United States of America. 108: E952-61. PMID 21949390 DOI: 10.1073/Pnas.1104969108  0.723
2011 Bernier M, Paul RK, Martin-Montalvo A, Scheibye-Knudsen M, Song S, He HJ, Armour SM, Hubbard BP, Bohr VA, Wang L, Zong Y, Sinclair DA, de Cabo R. Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. The Journal of Biological Chemistry. 286: 19270-9. PMID 21467030 DOI: 10.1074/Jbc.M110.200311  0.789
2011 Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, De Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice Journals of Gerontology - Series a Biological Sciences and Medical Sciences. 66: 191-201. PMID 20974732 DOI: 10.1093/Gerona/Glq178  0.339
2010 Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, ... ... Sinclair DA, et al. Dietary restriction: standing up for sirtuins. Science (New York, N.Y.). 329: 1012-3; author reply. PMID 20798296 DOI: 10.1126/Science.329.5995.1012  0.529
2010 Yang Y, Hubbard BP, Sinclair DA, Tong Q. Characterization of murine SIRT3 transcript variants and corresponding protein products. Journal of Cellular Biochemistry. 111: 1051-8. PMID 20677216 DOI: 10.1002/Jcb.22795  0.643
2010 Sinclair D, Hafner AV, Gomes A, Liang J, Cen Y, Lanza I, Nair S, Sauve A, Rozenzweig A. Does Declining Mitochondrial NAD+ and Unscheduled Opening of Mitochondrial Transition Pore Promote Mammalian Aging? Blood. 116: SCI-3-SCI-3. DOI: 10.1182/Blood.V116.21.Sci-3.Sci-3  0.378
2009 Armour SM, Baur JA, Hsieh SN, Land-Bracha A, Thomas SM, Sinclair DA. Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy. Aging. 1: 515-28. PMID 20157535  0.753
2008 Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA. The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. Plos One. 3: e2020. PMID 18414679 DOI: 10.1371/Journal.Pone.0002020  0.465
2007 Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, ... ... Sinclair DA, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 450: 712-6. PMID 18046409 DOI: 10.1038/Nature06261  0.786
2007 Medvedik O, Lamming DW, Kim KD, Sinclair DA. MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. Plos Biology. 5: e261. PMID 17914901 DOI: 10.1371/Journal.Pbio.0050261  0.798
2007 Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA. Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell. 130: 1095-107. PMID 17889652 DOI: 10.1016/J.Cell.2007.07.035  0.763
2007 Medvedik O, Sinclair DA. Caloric restriction and life span determination of yeast cells. Methods in Molecular Biology (Clifton, N.J.). 371: 97-109. PMID 17634577 DOI: 10.1007/978-1-59745-361-5_9  0.798
2007 Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. The Embo Journal. 26: 3169-79. PMID 17581637 DOI: 10.1038/Sj.Emboj.7601758  0.743
2006 Yu MC, Lamming DW, Eskin JA, Sinclair DA, Silver PA. The role of protein arginine methylation in the formation of silent chromatin. Genes & Development. 20: 3249-54. PMID 17158743 DOI: 10.1101/Gad.1495206  0.569
2006 Sinclair DA, Lin SJ, Guarente L. Life-span extension in yeast. Science (New York, N.Y.). 312: 195-7; author reply . PMID 16614198 DOI: 10.1126/Science.312.5771.195D  0.524
2006 Sinclair DA, Guarente L. Unlocking the secrets of longevity genes. Scientific American. 294: 48-51, 54-7. PMID 16502611 DOI: 10.1038/SCIENTIFICAMERICAN0306-48  0.396
2006 Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, Lin S, Sinclair DA. Response to Comment on "HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction" Science. 312: 1312-1312. DOI: 10.1126/Science.1124767  0.764
2005 Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, Lin SJ, Sinclair DA. HST2 mediates SIR2-independent life-span extension by calorie restriction. Science (New York, N.Y.). 309: 1861-4. PMID 16051752 DOI: 10.1126/Science.1113611  0.777
2005 Gama V, Yoshida T, Cohen H, Sinclair D, Yokota T, Distelhorst C, Matsuyama S. Poly-Glutamine Induces Bax-Mediated Cell Death by Dissociating Ku70 from Bax through Ku70-Acetylation. Blood. 106: 4299-4299. DOI: 10.1182/Blood.V106.11.4299.4299  0.31
2004 Lamming DW, Wood JG, Sinclair DA. Small molecules that regulate lifespan: evidence for xenohormesis. Molecular Microbiology. 53: 1003-9. PMID 15306006 DOI: 10.1111/J.1365-2958.2004.04209.X  0.594
2004 Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 430: 686-9. PMID 15254550 DOI: 10.1038/Nature02789  0.43
2004 Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, De Cabo R, Sinclair DA. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase Science. 305: 390-392. PMID 15205477 DOI: 10.1126/Science.1099196  0.793
2004 Cohen HY, Lavu S, Bitterman KJ, Hekking B, Imahiyerobo TA, Miller C, Frye R, Ploegh H, Kessler BM, Sinclair DA. Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Molecular Cell. 13: 627-38. PMID 15023334 DOI: 10.1016/S1097-2765(04)00094-2  0.767
2003 Anderson RM, Latorre-Esteves M, Neves AR, Lavu S, Medvedik O, Taylor C, Howitz KT, Santos H, Sinclair DA. Yeast life-span extension by calorie restriction is independent of NAD fluctuation. Science (New York, N.Y.). 302: 2124-6. PMID 14605207 DOI: 10.1126/Science.1088697  0.796
2003 Bitterman KJ, Medvedik O, Sinclair DA. Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiology and Molecular Biology Reviews : Mmbr. 67: 376-99, table of con. PMID 12966141 DOI: 10.1128/Mmbr.67.3.376-399.2003  0.795
2003 Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 425: 191-6. PMID 12939617 DOI: 10.1038/Nature01960  0.798
2003 Sinclair D. Is DNA cut out for a long life? Science of Aging Knowledge Environment : Sage Ke. 2003. PMID 12844521 DOI: 10.1126/Sageke.2003.16.Pe8  0.343
2003 Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature. 423: 181-5. PMID 12736687 DOI: 10.1038/Nature01578  0.789
2002 Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. The Journal of Biological Chemistry. 277: 45099-107. PMID 12297502 DOI: 10.1074/Jbc.M205670200  0.785
2002 Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Cohen H, Lin SS, Manchester JK, Gordon JI, Sinclair DA. Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. The Journal of Biological Chemistry. 277: 18881-90. PMID 11884393 DOI: 10.1074/Jbc.M111773200  0.791
1999 Ashrafi K, Sinclair D, Gordon JI, Guarente L. Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 96: 9100-5. PMID 10430902 DOI: 10.1073/Pnas.96.16.9100  0.564
1998 Sinclair D, Mills K, Guarente L. Aging in Saccharomyces cerevisiae Annual Review of Microbiology. 52: 533-560. PMID 9891807 DOI: 10.1146/Annurev.Micro.52.1.533  0.577
Low-probability matches (unlikely to be authored by this person)
2018 Pichardo I, Budnik B, Vera D, Kane A, Cooney M, Chwalek K, Rajman L, Sinclair D. Discovery Of A Novel Circulating Peptidome In Human Serum That Correlates With Aging Innovation in Aging. 2: 880-880. DOI: 10.1093/Geroni/Igy031.3285  0.292
2012 Franco SS, De Falco L, Ghaffari S, Brugnara C, Sinclair D, Iolascon A, Narla M, Bertoldi M, Lebouf C, Janin A, Siciliano A, Rimmele P, Cappellini MD, Michan S, Zoratti E, et al. Resveratrol Induces Erythroid Maturation by Activating FOXO3 and Improves in Vivo Erythropoiesis in Normal and Beta -Thalassemic Mice Blood. 120: 3191-3191. DOI: 10.1182/Blood.V120.21.3191.3191  0.288
2007 Michan S, Sinclair D. Sirtuins in mammals: insights into their biological function. The Biochemical Journal. 404: 1-13. PMID 17447894 DOI: 10.1042/BJ20070140  0.287
2019 Schultz MB, Rinaldi C, Lu Y, Amorim JA, Sinclair DA. Molecular and Cellular Characterization of SIRT1 Allosteric Activators. Methods in Molecular Biology (Clifton, N.J.). 1983: 133-149. PMID 31087296 DOI: 10.1007/978-1-4939-9434-2_8  0.285
2002 Sinclair DA. Paradigms and pitfalls of yeast longevity research Mechanisms of Ageing and Development. 123: 857-867. PMID 12044934 DOI: 10.1016/S0047-6374(02)00023-4  0.28
2001 Sinclair DA. Yeast aging research: recent advances and medical relevance. Cellular and Molecular Life Sciences : Cmls. 56: 807-16. PMID 11212340 DOI: 10.1007/s000180050027  0.28
2005 Sinclair D. Sirtuins for healthy neurons Nature Genetics. 37: 339-340. PMID 15800644 DOI: 10.1038/Ng0405-339  0.28
2011 Haigis MC, Sinclair DA. Sirtuins in aging and age-related diseases Handbook of the Biology of Aging. 243-274. DOI: 10.1016/B978-0-12-378638-8.00011-7  0.275
2007 Oberdoerffer P, Sinclair DA. The role of nuclear architecture in genomic instability and ageing. Nature Reviews. Molecular Cell Biology. 8: 692-702. PMID 17700626 DOI: 10.1038/nrm2238  0.274
2007 Barbosa MT, Soares SM, Novak CM, Sinclair D, Levine JA, Aksoy P, Chini EN. The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 3629-39. PMID 17585054 DOI: 10.1096/Fj.07-8290Com  0.273
2013 Lahti T, Halme J, Pankakoski M, Sinclair D, Alho H. Characteristics of Treatment Seeking Finnish Pathological Gamblers: Baseline Data from a Treatment Study. International Journal of Mental Health and Addiction. 11: 307-314. PMID 23710159 DOI: 10.1007/S11469-012-9411-4  0.265
2004 Mizuno T, Kishimoto T, Shinzato T, Haw R, Chambers A, Wood J, Sinclair D, Uemura H. Role of the N‐terminal region of Rap1p in the transcriptional activation of glycolytic genes in Saccharomyces cerevisiae Yeast. 21: 851-866. PMID 15300680 DOI: 10.1002/Yea.1123  0.261
2013 Sinclair D, Isba R, Kredo T, Zani B, Smith H, Garner P. World Health Organization guideline development: an evaluation. Plos One. 8: e63715. PMID 23741299 DOI: 10.1371/Journal.Pone.0063715  0.258
2018 Albert JB, Anton G, Badhrees I, Barbeau PS, Bayerlein R, Beck D, Belov V, Breidenbach M, Brunner T, Cao GF, Cen WR, Chambers C, Cleveland B, Coon M, Craycraft A, ... Sinclair D, et al. Search for Neutrinoless Double-Beta Decay with the Upgraded EXO-200 Detector. Physical Review Letters. 120: 072701. PMID 29542972 DOI: 10.1103/Physrevlett.120.072701  0.254
2018 Albert JB, Anton G, Arnquist IJ, Badhrees I, Barbeau P, Beck D, Belov V, Bourque F, Brodsky JP, Brown E, Brunner T, Burenkov A, Cao GF, Cao L, Cen WR, ... Sinclair D, et al. Sensitivity and discovery potential of the proposed nEXO experiment to neutrinoless double- β decay Physical Review C. 97: 65503. DOI: 10.1103/Physrevc.97.065503  0.253
2008 Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, ... ... Sinclair DA, et al. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 135: 907-18. PMID 19041753 DOI: 10.1016/J.Cell.2008.10.025  0.253
1990 Hayashi S, Ruddell A, Sinclair D, Grigliatti T. Chromosomal structure is altered by mutations that suppress or enhance position effect variegation. Chromosoma. 99: 391-400. PMID 2125551 DOI: 10.1007/Bf01726690  0.251
2013 Poirot E, Skarbinski J, Sinclair D, Kachur SP, Slutsker L, Hwang J. Mass drug administration for malaria. The Cochrane Database of Systematic Reviews. 12: CD008846. PMID 24318836 DOI: 10.1002/14651858.Cd008846.Pub2  0.251
2011 Bercik P, Park AJ, Sinclair D, Khoshdel A, Lu J, Huang X, Deng Y, Blennerhassett PA, Fahnestock M, Moine D, Berger B, Huizinga JD, Kunze W, McLean PG, Bergonzelli GE, et al. The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 23: 1132-9. PMID 21988661 DOI: 10.1111/J.1365-2982.2011.01796.X  0.249
2004 Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D. Erratum: corrigendum: Sirtuin activators mimic caloric restriction and delay ageing in metazoans Nature. 431: 107-107. DOI: 10.1038/Nature02941  0.249
2012 North BJ, Sinclair DA. The intersection between aging and cardiovascular disease. Circulation Research. 110: 1097-108. PMID 22499900 DOI: 10.1161/Circresaha.111.246876  0.249
2013 Rimmele P, Bigarella C, d'Escamard V, Izac B, Sinclair D, Ghaffari S. SIRT1 deacetylase is essential for hematopoietic stem cell activity Experimental Hematology. 41: S35. DOI: 10.1016/J.Exphem.2013.05.139  0.246
2014 Albert JB, Auger M, Auty DJ, Barbeau PS, Beauchamp E, Beck D, Belov V, Benitez-Medina C, Bonatt J, Breidenbach M, Brunner T, Burenkov A, Cao GF, Chambers C, Chaves J, ... Sinclair D, et al. Improved measurement of the 2 ν β β half-life of 136 Xe with the EXO-200 detector Physical Review C - Nuclear Physics. 89. DOI: 10.1103/Physrevc.89.015502  0.245
2005 Sinclair DA. Toward a unified theory of caloric restriction and longevity regulation. Mechanisms of Ageing and Development. 126: 987-1002. PMID 15893363 DOI: 10.1016/j.mad.2005.03.019  0.245
2019 Anton G, Badhrees I, Barbeau PS, Beck D, Belov V, Bhatta T, Breidenbach M, Brunner T, Cao GF, Cen WR, Chambers C, Cleveland B, Coon M, Craycraft A, Daniels T, ... Sinclair D, et al. Search for Neutrinoless Double-β Decay with the Complete EXO-200 Dataset. Physical Review Letters. 123: 161802. PMID 31702371 DOI: 10.1103/Physrevlett.123.161802  0.244
2012 Meremikwu MM, Donegan S, Sinclair D, Esu E, Oringanje C. Intermittent preventive treatment for malaria in children living in areas with seasonal transmission. The Cochrane Database of Systematic Reviews. 2: CD003756. PMID 22336792 DOI: 10.1002/14651858.Cd003756.Pub4  0.243
2015 Albert JB, Auty DJ, Barbeau PS, Beck D, Belov V, Benitez-Medina C, Breidenbach M, Brunner T, Burenkov A, Cao GF, Chambers C, Cleveland B, Coon M, Craycraft A, Daniels T, ... Sinclair D, et al. Investigation of radioactivity-induced backgrounds in EXO-200 Physical Review C - Nuclear Physics. 92. DOI: 10.1103/Physrevc.92.015503  0.242
2009 Jiménez-Hidalgo M, Santos-Ocaña C, Padilla S, Villalba JM, López-Lluch G, Martín-Montalvo A, Minor RK, Sinclair DA, de Cabo R, Navas P. NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell. 8: 140-51. PMID 19239415 DOI: 10.1111/J.1474-9726.2009.00461.X  0.241
2022 Suenkel B, Valente S, Zwergel C, Weiss S, Di Bello E, Fioravanti R, Aventaggiato M, Amorim JA, Garg N, Kumar S, Lombard DB, Hu T, Singh PK, Tafani M, Palmeira CM, ... Sinclair D, et al. Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5. Journal of Medicinal Chemistry. PMID 36228194 DOI: 10.1021/acs.jmedchem.2c01215  0.239
2010 Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, et al. Impact papers on aging in 2009. Aging. 2: 111-21. PMID 20351400 DOI: v2/n3/full/100132.html  0.239
2013 Gogtay N, Kannan S, Thatte UM, Olliaro PL, Sinclair D. Artemisinin-based combination therapy for treating uncomplicated Plasmodium vivax malaria. The Cochrane Database of Systematic Reviews. 10: CD008492. PMID 24163021 DOI: 10.1002/14651858.Cd008492.Pub3  0.238
2014 Zani B, Gathu M, Donegan S, Olliaro PL, Sinclair D. Dihydroartemisinin-piperaquine for treating uncomplicated Plasmodium falciparum malaria. The Cochrane Database of Systematic Reviews. 1: CD010927. PMID 24443033 DOI: 10.1002/14651858.Cd010927  0.238
2016 Bonkowski MS, Sinclair DA. Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds. Nature Reviews. Molecular Cell Biology. PMID 27552971 DOI: 10.1038/Nrm.2016.93  0.237
2016 Grobler L, Nagpal S, Sudarsanam TD, Sinclair D. Nutritional supplements for people being treated for active tuberculosis. The Cochrane Database of Systematic Reviews. 6: CD006086. PMID 27355911 DOI: 10.1002/14651858.Cd006086.Pub4  0.236
2016 Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, ... ... Sinclair DA, et al. Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metabolism. 23: 1093-1112. PMID 27304509 DOI: 10.1016/J.Cmet.2016.05.027  0.236
2017 Aharmim B, Ahmed SN, Anthony AE, Barros N, Beier EW, Bellerive A, Beltran B, Bergevin M, Biller SD, Boudjemline K, Boulay MG, Cai B, Chan YD, Chauhan D, Chen M, ... Sinclair D, et al. Search for neutron-Antineutron oscillations at the Sudbury Neutrino Observatory Physical Review D. 96: 92005. DOI: 10.1103/Physrevd.96.092005  0.235
2014 Uthman OA, Saunders R, Sinclair D, Graves P, Gelband H, Clarke A, Garner P. Safety of 8-aminoquinolines given to people with G6PD deficiency: protocol for systematic review of prospective studies. Bmj Open. 4: e004664. PMID 24833685 DOI: 10.1136/Bmjopen-2013-004664  0.235
2011 Guyatt GH, Oxman AD, Kunz R, Brozek J, Alonso-Coello P, Rind D, Devereaux PJ, Montori VM, Freyschuss B, Vist G, Jaeschke R, Williams JW, Murad MH, Sinclair D, Falck-Ytter Y, et al. GRADE guidelines 6. Rating the quality of evidence--imprecision. Journal of Clinical Epidemiology. 64: 1283-93. PMID 21839614 DOI: 10.1016/J.Jclinepi.2011.01.012  0.233
2015 González U, Pinart M, Sinclair D, Firooz A, Enk C, Vélez ID, Esterhuizen TM, Tristan M, Alvar J. Vector and reservoir control for preventing leishmaniasis. The Cochrane Database of Systematic Reviews. 8: CD008736. PMID 26246011 DOI: 10.1002/14651858.Cd008736.Pub2  0.232
2014 Rimmelé P, Bigarella CL, Liang R, Izac B, Dieguez-Gonzalez R, Barbet G, Donovan M, Brugnara C, Blander JM, Sinclair DA, Ghaffari S. Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells. Stem Cell Reports. 3: 44-59. PMID 25068121 DOI: 10.1016/J.Stemcr.2014.04.015  0.232
2014 Leibovici-Weissman Y, Neuberger A, Bitterman R, Sinclair D, Salam MA, Paul M. Antimicrobial drugs for treating cholera. The Cochrane Database of Systematic Reviews. 6: CD008625. PMID 24944120 DOI: 10.1002/14651858.Cd008625.Pub2  0.231
2004 Sarviharju M, Riikonen J, Jaatinen P, Sinclair D, Hervonen A, Kiianmaa K. Survival of AA and ANA rats during lifelong ethanol exposure. Alcoholism: Clinical and Experimental Research. 28: 93-97. PMID 14745306 DOI: 10.1097/01.Alc.0000106305.80993.6F  0.231
2022 Johnson AA, English BW, Shokhirev MN, Sinclair DA, Cuellar TL. Human age reversal: Fact or fiction? Aging Cell. e13664. PMID 35778957 DOI: 10.1111/acel.13664  0.231
2013 Rouvinen-Lagerström N, Lahti J, Alho H, Kovanen L, Aalto M, Partonen T, Silander K, Sinclair D, Räikkönen K, Eriksson JG, Palotie A, Koskinen S, Saarikoski ST. μ-Opioid receptor gene (OPRM1) polymorphism A118G: lack of association in Finnish populations with alcohol dependence or alcohol consumption. Alcohol and Alcoholism (Oxford, Oxfordshire). 48: 519-25. PMID 23729673 DOI: 10.1093/Alcalc/Agt050  0.23
2014 Bukirwa H, Unnikrishnan B, Kramer CV, Sinclair D, Nair S, Tharyan P. Artesunate plus pyronaridine for treating uncomplicated Plasmodium falciparum malaria. The Cochrane Database of Systematic Reviews. 3: CD006404. PMID 24596021 DOI: 10.1002/14651858.Cd006404.Pub2  0.229
2017 Jullien S, Sinclair D, Garner P. The impact of mass deworming programmes on schooling and economic development: an appraisal of long-term studies. International Journal of Epidemiology. PMID 28161712 DOI: 10.1093/Ije/Dyw283  0.229
2012 Sinclair D, Donegan S, Isba R, Lalloo DG. Artesunate versus quinine for treating severe malaria. The Cochrane Database of Systematic Reviews. 6: CD005967. PMID 22696354 DOI: 10.1002/14651858.Cd005967.Pub4  0.229
2015 Isba R, Zani B, Gathu M, Sinclair D. Artemisinin-naphthoquine for treating uncomplicated Plasmodium falciparum malaria. The Cochrane Database of Systematic Reviews. 2: CD011547. PMID 25702785 DOI: 10.1002/14651858.Cd011547  0.228
2001 Boening JA, Lesch OM, Spanagel R, Wolffgramm J, Narita M, Sinclair D, Mason BJ, Wiesbeck GA. Pharmacological relapse prevention in alcohol dependence: from animal models to clinical trials. Alcoholism, Clinical and Experimental Research. 25: 127S-131S. PMID 11391061 DOI: 10.1111/J.1530-0277.2001.Tb02386.X  0.228
2014 Wu LE, Gomes AP, Sinclair DA. Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis. Cancer Cell. 25: 12-9. PMID 24434207 DOI: 10.1016/j.ccr.2013.12.005  0.228
2023 Cipriano A, Moqri M, Maybury-Lewis SY, Rogers-Hammond R, de Jong TA, Parker A, Rasouli S, Schöler HR, Sinclair DA, Sebastiano V. Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming. Nature Aging. PMID 38102454 DOI: 10.1038/s43587-023-00539-2  0.228
2007 Yang H, Baur JA, Chen A, Miller C, Adams JK, Kisielewski A, Howitz KT, Zipkin RE, Sinclair DA. Design and synthesis of compounds that extend yeast replicative lifespan. Aging Cell. 6: 35-43. PMID 17156081 DOI: 10.1111/J.1474-9726.2006.00259.X  0.228
2014 North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The Embo Journal. 33: 1438-53. PMID 24825348 DOI: 10.15252/Embj.201386907  0.228
2013 Tusting LS, Thwing J, Sinclair D, Fillinger U, Gimnig J, Bonner KE, Bottomley C, Lindsay SW. Mosquito larval source management for controlling malaria. The Cochrane Database of Systematic Reviews. 8: CD008923. PMID 23986463 DOI: 10.1002/14651858.Cd008923.Pub2  0.228
2017 van der Heijden I, Abrahams N, Sinclair D. Psychosocial group interventions to improve psychological well-being in adults living with HIV. The Cochrane Database of Systematic Reviews. 3: CD010806. PMID 28291302 DOI: 10.1002/14651858.Cd010806.Pub2  0.228
2018 Rajman L, Chwalek K, Sinclair DA. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metabolism. 27: 529-547. PMID 29514064 DOI: 10.1016/j.cmet.2018.02.011  0.226
2020 Bertoldo MJ, Listijono DR, Ho WJ, Riepsamen AH, Goss DM, Richani D, Jin XL, Mahbub S, Campbell JM, Habibalahi A, Loh WN, Youngson NA, Maniam J, Wong ASA, Selesniemi K, ... ... Sinclair DA, et al. NAD Repletion Rescues Female Fertility during Reproductive Aging. Cell Reports. 30: 1670-1681.e7. PMID 32049001 DOI: 10.1016/j.celrep.2020.01.058  0.226
2004 Ahmed SN, Anthony AE, Beier EW, Bellerive A, Biller SD, Boger J, Boulay MG, Bowler MG, Bowles TJ, Brice SJ, Bullard TV, Chan YD, Chen M, Chen X, Cleveland BT, ... Sinclair D, et al. Measurement of the total active 8B solar neutrino flux at the Sudbury Neutrino Observatory with enhanced neutral current sensitivity. Physical Review Letters. 92: 181301. PMID 15169480 DOI: 10.1103/Physrevlett.92.181301  0.226
2013 Okwundu CI, Nagpal S, Musekiwa A, Sinclair D. Home- or community-based programmes for treating malaria. The Cochrane Database of Systematic Reviews. 5: CD009527. PMID 23728693 DOI: 10.1002/14651858.Cd009527.Pub2  0.226
1981 West M, Sinclair D, Southwell-Keely P. On the stoichiometry of oxygen metabolism in polymorphonuclear leukocytes. Biochemical and Biophysical Research Communications. 100: 212-218. PMID 6266399 DOI: 10.1016/S0006-291X(81)80084-8  0.226
2013 Nagpal S, Sinclair D, Garner P. Has the NTD community neglected evidence-based policy? Plos Neglected Tropical Diseases. 7: e2238. PMID 23875030 DOI: 10.1371/Journal.Pntd.0002238  0.226
2013 Danso-Appiah A, Olliaro PL, Donegan S, Sinclair D, Utzinger J. Drugs for treating Schistosoma mansoni infection. The Cochrane Database of Systematic Reviews. 2: CD000528. PMID 23450530 DOI: 10.1002/14651858.Cd000528.Pub2  0.225
2015 Clasen TF, Alexander KT, Sinclair D, Boisson S, Peletz R, Chang HH, Majorin F, Cairncross S. Interventions to improve water quality for preventing diarrhoea. The Cochrane Database of Systematic Reviews. 10: CD004794. PMID 26488938 DOI: 10.1002/14651858.Cd004794.Pub3  0.225
2009 Sinclair D, Zani B, Donegan S, Olliaro P, Garner P. Artemisinin-based combination therapy for treating uncomplicated malaria. The Cochrane Database of Systematic Reviews. CD007483. PMID 19588433 DOI: 10.1002/14651858.Cd007483.Pub2  0.224
2011 Effa EE, Lassi ZS, Critchley JA, Garner P, Sinclair D, Olliaro PL, Bhutta ZA. Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). The Cochrane Database of Systematic Reviews. CD004530. PMID 21975746 DOI: 10.1002/14651858.Cd004530.Pub4  0.224
2016 Albert JB, Auty DJ, Barbeau PS, Beck D, Belov V, Breidenbach M, Brunner T, Burenkov A, Cao GF, Chambers C, Chaves J, Cleveland B, Coon M, Craycraft A, Daniels T, ... Sinclair D, et al. Search for 2νββ decay of Xe 136 to the 01+ excited state of Ba 136 with the EXO-200 liquid xenon detector Physical Review C - Nuclear Physics. 93. DOI: 10.1103/Physrevc.93.035501  0.224
2006 Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, ... ... Sinclair DA, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 444: 337-42. PMID 17086191 DOI: 10.1038/Nature05354  0.223
2015 Lutge EE, Wiysonge CS, Knight SE, Sinclair D, Volmink J. Incentives and enablers to improve adherence in tuberculosis. The Cochrane Database of Systematic Reviews. 9: CD007952. PMID 26333525 DOI: 10.1002/14651858.Cd007952.Pub3  0.223
2008 Leonard DS, Grinberg P, Weber P, Baussan E, Djurcic Z, Keefer G, Piepke A, Pocar A, Vuilleumier JL, Vuilleumier JM, Akimov D, Bellerive A, Bowcock M, Breidenbach M, Burenkov A, ... Sinclair D, et al. Systematic study of trace radioactive impurities in candidate construction materials for EXO-200 Nuclear Instruments and Methods in Physics Research, Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 591: 490-509. DOI: 10.1016/J.Nima.2008.03.001  0.223
2009 Sinclair DA, Oberdoerffer P. The ageing epigenome: damaged beyond repair? Ageing Research Reviews. 8: 189-98. PMID 19439199 DOI: 10.1016/j.arr.2009.04.004  0.222
2013 Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, ... ... Sinclair DA, et al. Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide. Nature Chemical Biology. 9: 693-700. PMID 24077178 DOI: 10.1038/Nchembio.1352  0.222
2014 Odaga J, Sinclair D, Lokong JA, Donegan S, Hopkins H, Garner P. Rapid diagnostic tests versus clinical diagnosis for managing people with fever in malaria endemic settings. The Cochrane Database of Systematic Reviews. 4: CD008998. PMID 24740584 DOI: 10.1002/14651858.Cd008998.Pub2  0.221
2008 Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, ... ... Sinclair DA, et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metabolism. 8: 157-68. PMID 18599363 DOI: 10.1016/J.Cmet.2008.06.011  0.221
2006 Yang H, Lavu S, Sinclair DA. Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity? Experimental Gerontology. 41: 718-26. PMID 16842957 DOI: 10.1016/J.Exger.2006.06.003  0.221
2019 Amano H, Chaudhury A, Rodriguez-Aguayo C, Lu L, Akhanov V, Catic A, Popov YV, Verdin E, Johnson H, Stossi F, Sinclair DA, Nakamaru-Ogiso E, Lopez-Berestein G, Chang JT, Neilson JR, et al. Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease. Cell Metabolism. PMID 30930169 DOI: 10.1016/J.Cmet.2019.03.001  0.221
2016 Albert JB, Auty DJ, Barbeau PS, Beck D, Belov V, Breidenbach M, Brunner T, Burenkov A, Cao GF, Chambers C, Cleveland B, Coon M, Craycraft A, Daniels T, Danilov M, ... Sinclair D, et al. Cosmogenic backgrounds to 0νββ in EXO-200 Journal of Cosmology and Astroparticle Physics. 2016. DOI: 10.1088/1475-7516/2016/04/029  0.221
2022 Gold DA, Sinclair DA. Sirtuin Evolution at the Dawn of Animal Life. Molecular Biology and Evolution. PMID 36065792 DOI: 10.1093/molbev/msac192  0.22
2001 McDonald AB, Boulay MG, Bovin E, Chen M, Duncan FA, Earle ED, Evans HC, Ewan GT, Ford RJ, Hallin AL, Harvey PJ, Hepburn JD, Jillings C, Lee HW, Leslie JR, ... Sinclair D, et al. Neutrino observations from the Sudbury Neutrino Observatory Lawrence Berkeley National Laboratory. 91: 21-28. DOI: 10.1016/S0920-5632(00)00918-X  0.22
2019 Aharmim B, Stonehill LC, Leslie JR, Krüger A, Gilje K, Fergani H, Seibert SR, O'Keeffe HM, Bonventre R, McDonald AB, Wall BL, Monreal B, Dunford M, Ford RJ, Wark DL, ... Sinclair D, et al. Measurement of neutron production in atmospheric neutrino interactions at the Sudbury Neutrino Observatory Physical Review D. 99: 112007. DOI: 10.1103/Physrevd.99.112007  0.22
2012 Tenhola H, Sinclair D, Alho H, Lahti T. Effect of opioid antagonists on sex hormone secretion. Journal of Endocrinological Investigation. 35: 227-230. PMID 22183092 DOI: 10.3275/8181  0.219
2018 Jewell M, Schubert A, Cen W, Dalmasson J, DeVoe R, Fabris L, Gratta G, Jamil A, Li G, Odian A, Patel M, Pocar A, Qiu D, Wang Q, Wen L, ... Sinclair D, et al. Characterization of an Ionization Readout Tile for nEXO Journal of Instrumentation. 13: P01006-P01006. DOI: 10.1088/1748-0221/13/01/P01006  0.219
2014 Kramer CV, Zhang F, Sinclair D, Olliaro PL. Drugs for treating urinary schistosomiasis. The Cochrane Database of Systematic Reviews. 8: CD000053. PMID 25099517 DOI: 10.1002/14651858.Cd000053.Pub3  0.219
2014 Twelker K, Kravitz S, Montero Díez M, Gratta G, Fairbank W, Albert JB, Auty DJ, Barbeau PS, Beck D, Benitez-Medina C, Breidenbach M, Brunner T, Cao GF, Chambers C, Cleveland B, ... Sinclair D, et al. An apparatus to manipulate and identify individual Ba ions from bulk liquid Xe. The Review of Scientific Instruments. 85: 095114. PMID 25273779 DOI: 10.1063/1.4895646  0.219
2013 Sinclair D, Gyansa-Lutterodt M, Asare B, Koduah A, Andrews E, Garner P. Integrating global and national knowledge to select medicines for children: the Ghana National Drugs Programme. Plos Medicine. 10: e1001449. PMID 23704834 DOI: 10.1371/Journal.Pmed.1001449  0.218
2017 Leonard D, Auty D, Didberidze T, Gornea R, Grinberg P, MacLellan R, Methven B, Piepke A, Vuilleumier J, Albert J, Anton G, Badhrees I, Barbeau P, Bayerlein R, Beck D, ... Sinclair D, et al. Trace radioactive impurities in final construction materials for EXO-200 Nuclear Instruments and Methods in Physics Research Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 871: 169-179. DOI: 10.1016/J.Nima.2017.04.049  0.218
2002 Ahmad QR, Allen RC, Andersen TC, Anglin JD, Barton JC, Beier EW, Bercovitch M, Bigu J, Biller SD, Black RA, Blevis I, Boardman RJ, Boger J, Bonvin E, Boulay MG, ... Sinclair D, et al. Measurement of day and night neutrino energy spectra at SNO and constraints on neutrino mixing parameters. Physical Review Letters. 89: 011302. PMID 12097026 DOI: 10.1103/Physrevlett.89.011302  0.218
2001 Ahmad QR, Allen RC, Andersen TC, Anglin JD, Bühler G, Barton JC, Beier EW, Bercovitch M, Bigu J, Biller S, Black RA, Blevis I, Boardman RJ, Boger J, Bonvin E, ... Sinclair D, et al. Measurement of the rate of nu(e) + d --> p + p + e(-) interactions produced by (8)B solar neutrinos at the Sudbury Neutrino Observatory. Physical Review Letters. 87: 071301. PMID 11497878 DOI: 10.1103/Physrevlett.87.071301  0.218
2021 Ke S, Mitchell SJ, MacArthur MR, Kane AE, Sinclair DA, Venable EM, Chadaideh KS, Carmody RN, Grodstein F, Mitchell JR, Liu Y. Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice. Nutrients. 13. PMID 34579167 DOI: 10.3390/nu13093290  0.218
2020 Al Kharusi S, Anton G, Badhrees I, Barbeau PS, Beck D, Belov V, Bhatta T, Breidenbach M, Brunner T, Cao GF, Cen WR, Chambers C, Cleveland B, Coon M, Craycraft A, ... Sinclair D, et al. Measurement of the Spectral Shape of the β-Decay of ^{137}Xe to the Ground State of ^{137}Cs in EXO-200 and Comparison with Theory. Physical Review Letters. 124: 232502. PMID 32603173 DOI: 10.1103/Physrevlett.124.232502  0.217
2012 Auger M, Auty DJ, Barbeau PS, Beauchamp E, Belov V, Benitez-Medina C, Breidenbach M, Brunner T, Burenkov A, Cleveland B, Cook S, Daniels T, Danilov M, Davis CG, Delaquis S, ... Sinclair D, et al. Search for neutrinoless double-beta decay in 136Xe with EXO-200. Physical Review Letters. 109: 032505. PMID 22861843 DOI: 10.1103/Physrevlett.109.032505  0.217
2004 Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (New York, N.Y.). 303: 2011-5. PMID 14976264 DOI: 10.1126/Science.1094637  0.217
2021 Scott AJ, Ellison M, Sinclair DA. The economic value of targeting aging. Nature Aging. 1: 616-623. PMID 37117804 DOI: 10.1038/s43587-021-00080-0  0.216
2007 North BJ, Sinclair DA. Sirtuins: a conserved key unlocking AceCS activity. Trends in Biochemical Sciences. 32: 1-4. PMID 17141505 DOI: 10.1016/J.Tibs.2006.11.002  0.216
2017 Visser ME, Durao S, Sinclair D, Irlam JH, Siegfried N. Micronutrient supplementation in adults with HIV infection. The Cochrane Database of Systematic Reviews. 5: CD003650. PMID 28518221 DOI: 10.1002/14651858.Cd003650.Pub4  0.215
2016 Schultz MB, Sinclair DA. Why NAD(+) Declines during Aging: It's Destroyed. Cell Metabolism. 23: 965-6. PMID 27304496 DOI: 10.1016/j.cmet.2016.05.022  0.215
2014 Mitchell SJ, Martin-Montalvo A, Mercken EM, Palacios HH, Ward TM, Abulwerdi G, Minor RK, Vlasuk GP, Ellis JL, Sinclair DA, Dawson J, Allison DB, Zhang Y, Becker KG, Bernier M, et al. The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet. Cell Reports. 6: 836-43. PMID 24582957 DOI: 10.1016/J.Celrep.2014.01.031  0.215
2018 Albert JB, Anton G, Badhrees I, Barbeau PS, Bayerlein R, Beck D, Belov V, Breidenbach M, Brunner T, Cao GF, Cen WR, Chambers C, Cleveland B, Coon M, Craycraft A, ... Sinclair D, et al. Search for Nucleon Decays With EXO-200 Physical Review D. 97: 72007. DOI: 10.1103/Physrevd.97.072007  0.215
2011 Sinclair D, Abba K, Zaman K, Qadri F, Graves PM. Oral vaccines for preventing cholera. The Cochrane Database of Systematic Reviews. CD008603. PMID 21412922 DOI: 10.1002/14651858.Cd008603.Pub2  0.214
2009 Jin L, Galonek H, Israelian K, Choy W, Morrison M, Xia Y, Wang X, Xu Y, Yang Y, Smith JJ, Hoffmann E, Carney DP, Perni RB, Jirousek MR, Bemis JE, ... ... Sinclair DA, et al. Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3. Protein Science : a Publication of the Protein Society. 18: 514-25. PMID 19241369 DOI: 10.1002/pro.50  0.214
2010 Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annual Review of Pathology. 5: 253-95. PMID 20078221 DOI: 10.1146/Annurev.Pathol.4.110807.092250  0.214
2012 Auger M, Auty DJ, Barbeau PS, Bartoszek L, Baussan E, Beauchamp E, Benitez-Medina C, Breidenbach M, Chauhan D, Cleveland B, Conley R, Cook J, Cook S, Coppens A, Craddock W, ... Sinclair D, et al. The EXO-200 detector, part I: Detector design and construction Journal of Instrumentation. 7. DOI: 10.1088/1748-0221/7/05/P05010  0.212
2012 Dobi A, Hall C, Slutsky S, Yen YR, Aharmin B, Auger M, Barbeau PS, Benitez-Medina C, Breidenbach M, Cleveland B, Conley R, Cook J, Cook S, Counts I, Craddock W, ... Sinclair D, et al. Xenon purity analysis for EXO-200 via mass spectrometry Nuclear Instruments and Methods in Physics Research, Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 675: 40-46. DOI: 10.1016/J.Nima.2012.01.066  0.212
2003 Sinclair DA. Cell biology. An age of instability. Science (New York, N.Y.). 301: 1859-60. PMID 14512612 DOI: 10.1126/SCIENCE.1090465  0.211
2000 Hazell R, Sinclair D. The British Constitution: Labour’s Constitutional Revolution Annual Review of Political Science. 3: 379-400. DOI: 10.1146/Annurev.Polisci.3.1.379  0.211
1999 Hazell R, Sinclair D. Constitutional futures: transforming the UK’s political landscape Foresight. 1: 333-341. DOI: 10.1108/14636689910802241  0.211
2014 Franco SS, De Falco L, Ghaffari S, Brugnara C, Sinclair DA, Matte' A, Iolascon A, Mohandas N, Bertoldi M, An X, Siciliano A, Rimmelé P, Cappellini MD, Michan S, Zoratti E, et al. Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice. Haematologica. 99: 267-75. PMID 23975182 DOI: 10.3324/haematol.2013.090076  0.211
2014 Kliner M, Poole K, Sinclair D, Garner P. Preventing malaria in international travellers: an evaluation of published English-language guidelines. Bmc Public Health. 14: 1129. PMID 25367677 DOI: 10.1186/1471-2458-14-1129  0.21
2000 Hazell R, Russell M, Seyd B, Sinclair D. The British constitution in 1998-99: the continuing revolution Parliamentary Affairs. 53: 242-261. DOI: 10.1093/Pa/53.2.242  0.21
2003 Andersen TC, Blevis I, Boger J, Bonvin E, Chen M, Cleveland BT, Dai X, Dalnoki-Veress F, Doucas G, Farine J, Fergani H, Ferraris AP, Fowler MM, Hahn RL, Hallman ED, ... Sinclair D, et al. Measurement of radium concentration in water with Mn-coated beads at the Sudbury Neutrino Observatory Nuclear Instruments and Methods in Physics Research, Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 501: 399-417. DOI: 10.1016/S0168-9002(03)00616-8  0.21
2003 Andersen TC, Black RA, Blevis I, Boger J, Bonvin E, Chen M, Cleveland BT, Dai X, Dalnoki-Veress F, Doucas G, Farine J, Fergani H, Fowler MM, Hahn RL, Hallman ED, ... Sinclair D, et al. A radium assay technique using hydrous titanium oxide adsorbent for the Sudbury Neutrino Observatory Nuclear Instruments and Methods in Physics Research, Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 501: 386-398. DOI: 10.1016/S0168-9002(02)01925-3  0.209
2016 Ochodo E, Garner P, Sinclair D. Achieving universal testing for malaria. Bmj (Clinical Research Ed.). 352: i107. PMID 26846146 DOI: 10.1136/Bmj.I107  0.209
2020 Anton G, Badhrees I, Barbeau PS, Beck D, Belov V, Bhatta T, Breidenbach M, Brunner T, Cao GF, Cen WR, Chambers C, Cleveland B, Coon M, Craycraft A, Daniels T, ... Sinclair D, et al. Measurement of the scintillation and ionization response of liquid xenon at MeV energies in the EXO-200 experiment Physical Review C. 101: 65501. DOI: 10.1103/Physrevc.101.065501  0.209
2002 Ahmad QR, Allen RC, Andersen TC, D Anglin J, Barton JC, Beier EW, Bercovitch M, Bigu J, Biller SD, Black RA, Blevis I, Boardman RJ, Boger J, Bonvin E, Boulay MG, ... Sinclair D, et al. Direct evidence for neutrino flavor transformation from neutral-current interactions in the Sudbury Neutrino Observatory. Physical Review Letters. 89: 011301. PMID 12097025 DOI: 10.1103/Physrevlett.89.011301  0.208
2018 Dai H, Sinclair DA, Ellis JL, Steegborn C. Sirtuin activators and inhibitors: Promises, achievements, and challenges. Pharmacology & Therapeutics. PMID 29577959 DOI: 10.1016/J.Pharmthera.2018.03.004  0.208
2017 Albert JB, Anton G, Badhrees I, Barbeau PS, Bayerlein R, Beck D, Belov V, Breidenbach M, Brunner T, Cao GF, Cen WR, Chambers C, Cleveland B, Coon M, Craycraft A, ... Sinclair D, et al. Searches for double beta decay of ^(134)Xe with EXO-200 Physical Review D. 96: 92001. DOI: 10.1103/Physrevd.96.092001  0.208
2018 Jamil A, Ziegler T, Hufschmidt P, Li G, Lupin-Jimenez L, Michel T, Ostrovskiy I, Retiere F, Schneider J, Wagenpfeil M, Alamre A, Albert JB, Anton G, Arnquist IJ, Badhrees I, ... Sinclair D, et al. VUV-Sensitive Silicon Photomultipliers for Xenon Scintillation Light Detection in nEXO Ieee Transactions On Nuclear Science. 65: 2823-2833. DOI: 10.1109/Tns.2018.2875668  0.208
2012 Heinälä P, Lahti T, Sinclair D, Ariniemi K, Lillsunde P, Alho H. Analysis of naltrexone and its metabolite 6-beta-naltrexol in serum with high-performance liquid chromatography. Bmc Research Notes. 5: 439. PMID 22894733 DOI: 10.1186/1756-0500-5-439  0.207
2016 Albert JB, Barbeau PS, Beck D, Belov V, Breidenbach M, Brunner T, Burenkov A, Cao GF, Chambers C, Cleveland B, Coon M, Craycraft A, Daniels T, Danilov M, Daugherty SJ, ... Sinclair D, et al. First search for Lorentz and CPT violation in double beta decay with EXO-200 Physical Review D - Particles, Fields, Gravitation and Cosmology. 93. DOI: 10.1103/Physrevd.93.072001  0.207
2004 Blevis I, Boger J, Bonvin E, Cleveland BT, Dai X, Dalnoki-Veress F, Doucas G, Farine J, Fergani H, Grant D, Hahn RL, Hamer AS, Hargrove CK, Heron H, Jagam P, ... Sinclair D, et al. Measurement of 222Rn dissolved in water at the Sudbury Neutrino Observatory Nuclear Instruments and Methods in Physics Research, Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 517: 139-153. DOI: 10.1016/J.Nima.2003.10.103  0.207
2004 Ahmed SN, Anthony AE, Beier EW, Bellerive A, Biller SD, Boger J, Boulay MG, Bowler MG, Bowles TJ, Brice SJ, Bullard TV, Chan YD, Chen M, Chen X, Cleveland BT, ... Sinclair D, et al. Constraints on nucleon decay via invisible modes from the Sudbury Neutrino Observatory. Physical Review Letters. 92: 102004. PMID 15089201 DOI: 10.1103/Physrevlett.92.102004  0.206
2014 Liu Q, Abba K, Alejandria MM, Sinclair D, Balanag VM, Lansang MA. Reminder systems to improve patient adherence to tuberculosis clinic appointments for diagnosis and treatment. The Cochrane Database of Systematic Reviews. 11: CD006594. PMID 25403701 DOI: 10.1002/14651858.Cd006594.Pub3  0.206
2015 Kim J, Sturgill D, Tran AD, Sinclair DA, Oberdoerffer P. Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability. Nucleic Acids Research. PMID 26687720 DOI: 10.1093/Nar/Gkv1482  0.206
2014 Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proceedings of the National Academy of Sciences of the United States of America. 111: 3781-6. PMID 24556985 DOI: 10.1073/Pnas.1400705111  0.206
2010 Montero Díez M, Twelker K, Fairbank W, Gratta G, Barbeau PS, Barry K, DeVoe R, Dolinski MJ, Green M, LePort F, Müller AR, Neilson R, O'Sullivan K, Ackerman N, Aharmin B, ... Sinclair D, et al. A simple radionuclide-driven single-ion source. The Review of Scientific Instruments. 81: 113301. PMID 21133463 DOI: 10.1063/1.3499505  0.206
2015 Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, ... ... Sinclair DA, et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell. 14: 497-510. PMID 25902704 DOI: 10.1111/Acel.12338  0.205
2010 Hafner AV, Dai J, Gomes AP, Xiao CY, Palmeira CM, Rosenzweig A, Sinclair DA. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging. 2: 914-23. PMID 21212461  0.205
2013 Ahmed T, Bhuiyan TR, Zaman K, Sinclair D, Qadri F. Vaccines for preventing enterotoxigenic Escherichia coli (ETEC) diarrhoea. The Cochrane Database of Systematic Reviews. 7: CD009029. PMID 23828581 DOI: 10.1002/14651858.Cd009029.Pub2  0.205
1992 Laitinen K, Sinclair D, Nurmi M, Hietala R, Kröger H, Kiianmaa K, Salaspuro M. Effect of Calcitonin on the Alcohol Drinking of Rats Alcoholism: Clinical and Experimental Research. 16: 875-880. PMID 1443424 DOI: 10.1111/J.1530-0277.1992.Tb01885.X  0.205
2015 Winnik S, Auwerx J, Sinclair DA, Matter CM. Protective effects of sirtuins in cardiovascular diseases: from bench to bedside. European Heart Journal. PMID 26112889 DOI: 10.1093/eurheartj/ehv290  0.205
2014 Albert JB, Auty DJ, Barbeau PS, Beauchamp E, Beck D, Belov V, Benitez-Medina C, Breidenbach M, Brunner T, Burenkov A, Cao GF, Chambers C, Chaves J, Cleveland B, Coon M, ... Sinclair D, et al. Search for Majoron-emitting modes of double-beta decay of Xe 136 with EXO-200 Physical Review D - Particles, Fields, Gravitation and Cosmology. 90. DOI: 10.1103/Physrevd.90.092004  0.205
2016 Santesso N, Carrasco-Labra A, Langendam M, Brignardello-Petersen R, Mustafa RA, Heus P, Lasserson T, Opiyo N, Kunnamo I, Sinclair D, Garner P, Treweek S, Tovey D, Akl EA, Tugwell P, et al. Improving GRADE Evidence Tables part 3: Guidance for useful GRADE certainty in the evidence judgments through explanatory footnotes. Journal of Clinical Epidemiology. PMID 26796947 DOI: 10.1016/J.Jclinepi.2015.12.006  0.204
1999 Hazell R, Sinclair D. The British constitution in 1997-98: Labour's constitutional revolution Parliamentary Affairs. 52: 161-178. DOI: 10.1093/Pa/52.2.161  0.204
2013 Gratta G, Sinclair D. Present status and future perspectives for the EXO-200 experiment Advances in High Energy Physics. 2013. DOI: 10.1155/2013/545431  0.204
2017 Das A, Sinclair D, Bonkowski M, Johnston I, Wu L. Extension of physical endurance and protection against physical, chemical and radiological trauma by NAD + precursors Journal of Science and Medicine in Sport. 20: S165-S166. DOI: 10.1016/J.Jsams.2017.09.564  0.203
2011 Ackerman N, Aharmim B, Auger M, Auty DJ, Barbeau PS, Barry K, Bartoszek L, Beauchamp E, Belov V, Benitez-Medina C, Breidenbach M, Burenkov A, Cleveland B, Conley R, Conti E, ... Sinclair D, et al. Observation of two-neutrino double-beta decay in 136Xe with the EXO-200 detector. Physical Review Letters. 107: 212501. PMID 22181874 DOI: 10.1103/Physrevlett.107.212501  0.203
2007 Flatt B, Green M, Wodin J, DeVoe R, Fierlinger P, Gratta G, LePort F, Montero Díez M, Neilson R, O'Sullivan K, Pocar A, Waldman S, Baussan E, Breidenbach M, Conley R, ... Sinclair D, et al. A linear RFQ ion trap for the Enriched Xenon Observatory Nuclear Instruments and Methods in Physics Research, Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 578: 399-408. DOI: 10.1016/J.Nima.2007.05.123  0.203
2019 Kane AE, Sinclair DA. Epigenetic changes during aging and their reprogramming potential. Critical Reviews in Biochemistry and Molecular Biology. 1-23. PMID 30822165 DOI: 10.1080/10409238.2019.1570075  0.202
2013 Tilly JL, Sinclair DA. Germline energetics, aging, and female infertility. Cell Metabolism. 17: 838-50. PMID 23747243 DOI: 10.1016/J.Cmet.2013.05.007  0.201
2022 Scott A, Ashwin J, Ellison M, Sinclair D. International Gains to Achieving Healthy Longevity. Cold Spring Harbor Perspectives in Medicine. PMID 36096548 DOI: 10.1101/cshperspect.a041202  0.201
2013 Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, ... ... Sinclair DA, et al. Metformin improves healthspan and lifespan in mice. Nature Communications. 4: 2192. PMID 23900241 DOI: 10.1038/Ncomms3192  0.201
2008 Dai X, Rollin E, Bellerive A, Hargrove C, Sinclair D, Mifflin C, Zhang F. Wavelength shifters for water Cherenkov detectors Nuclear Instruments and Methods in Physics Research Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 589: 290-295. DOI: 10.1016/J.Nima.2008.01.101  0.201
2008 Muhonen LH, Lahti J, Sinclair D, Lönnqvist J, Alho H. Treatment of alcohol dependence in patients with co-morbid major depressive disorder--predictors for the outcomes with memantine and escitalopram medication. Substance Abuse Treatment, Prevention, and Policy. 3: 20. PMID 18834506 DOI: 10.1186/1747-597X-3-20  0.201
2019 Bolderson E, Burgess JT, Li J, Gandhi NS, Boucher D, Croft LV, Beard S, Plowman JJ, Suraweera A, Adams MN, Naqi A, Zhang SD, Sinclair DA, O'Byrne KJ, Richard DJ. Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage. Nature Communications. 10: 5501. PMID 31796734 DOI: 10.1038/S41467-019-13167-5  0.201
2018 Kane AE, Sinclair DA. Sirtuins and NAD in the Development and Treatment of Metabolic and Cardiovascular Diseases. Circulation Research. 123: 868-885. PMID 30355082 DOI: 10.1161/CIRCRESAHA.118.312498  0.201
2018 Latorre-Muro P, Baeza J, Armstrong EA, Hurtado-Guerrero R, Corzana F, Wu LE, Sinclair DA, López-Buesa P, Carrodeguas JA, Denu JM. Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions. Molecular Cell. 71: 718-732.e9. PMID 30193097 DOI: 10.1016/J.Molcel.2018.07.031  0.2
2017 Mhimbira FA, Cuevas LE, Dacombe R, Mkopi A, Sinclair D. Interventions to increase tuberculosis case detection at primary healthcare or community-level services. The Cochrane Database of Systematic Reviews. 11: CD011432. PMID 29182800 DOI: 10.1002/14651858.Cd011432.Pub2  0.2
2023 Wu LE, Fiveash CE, Bentley NL, Kang MJ, Govindaraju H, Barbour JA, Wilkins BP, Hancock SE, Madawala R, Das A, Massudi H, Li C, Kim LJ, Wong ASA, Marinova MB, ... ... Sinclair DA, et al. SIRT2 transgenic over-expression does not impact lifespan in mice. Aging Cell. e14027. PMID 38009412 DOI: 10.1111/acel.14027  0.2
2014 Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, ... ... Sinclair DA, et al. SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell. 13: 787-96. PMID 24931715 DOI: 10.1111/Acel.12220  0.2
1933 Pegram GB, Compton AH, Davis B, Sinclair D, Brown WF. THE SCIENTIFIC WORK OF THE GOVERNMENT. Science (New York, N.Y.). 78: 122-3. PMID 17749820 DOI: 10.1126/Science.78.2015.122  0.199
2016 Davis CG, Hall C, Albert JB, Barbeau PS, Beck DH, Belov V, Breidenbach M, Brunner T, Burenkov A, Cao GF, Cen WR, Chambers C, Cleveland B, Coon M, Craycraft A, ... Sinclair D, et al. An Optimal Energy Estimator to Reduce Correlated Noise for the EXO-200 Light Readout Journal of Instrumentation. 11: 7015. DOI: 10.1088/1748-0221/11/07/P07015  0.197
2016 Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, ... ... Sinclair DA, et al. NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. Cell Metabolism. 24: 566-581. PMID 27732836 DOI: 10.1016/J.Cmet.2016.09.004  0.197
2018 Sun X, Tolba T, Cao G, Lv P, Wen L, Odian A, Vachon F, Alamre A, Albert J, Anton G, Arnquist I, Badhrees I, Barbeau P, Beck D, Belov V, ... Sinclair D, et al. Study of silicon photomultiplier performance in external electric fields Journal of Instrumentation. 13: T09006-T09006. DOI: 10.1088/1748-0221/13/09/T09006  0.197
2014 Opiyo N, Molyneux E, Sinclair D, Garner P, English M. Immediate fluid management of children with severe febrile illness and signs of impaired circulation in low-income settings: a contextualised systematic review. Bmj Open. 4: e004934. PMID 24785400 DOI: 10.1136/Bmjopen-2014-004934  0.196
1956 Sinclair D. Automatic balance for measurement of the strength of glass fibers Review of Scientific Instruments. 27: 34-36. DOI: 10.1063/1.1715359  0.196
2015 Mong B, Cook S, Walton T, Chambers C, Craycraft A, Benitez-Medina C, Hall K, Fairbank W, Albert JB, Auty DJ, Barbeau PS, Basque V, Beck D, Breidenbach M, Brunner T, ... Sinclair D, et al. Spectroscopy of Ba and Ba+ deposits in solid xenon for barium tagging in nEXO Physical Review a - Atomic, Molecular, and Optical Physics. 91. DOI: 10.1103/Physreva.91.022505  0.195
2007 Green M, Wodin J, Devoe R, Fierlinger P, Flatt B, Gratta G, Leport F, Montero Díez M, Neilson R, O'sullivan K, Pocar A, Waldman S, Leonard DS, Piepke A, Hargrove C, Sinclair D, et al. Observation of single collisionally cooled trapped ions in a buffer gas Physical Review a - Atomic, Molecular, and Optical Physics. 76. DOI: 10.1103/Physreva.76.023404  0.195
2014 Hoog AHv, Langendam M, Mitchell E, Cobelens FG, Sinclair D, Leeflang MMG, Lönnroth K. Symptom‐ and chest‐radiography screening for active pulmonary tuberculosis in HIV‐negative adults and adults with unknown HIV status Cochrane Database of Systematic Reviews. DOI: 10.1002/14651858.Cd010890  0.195
2017 Bustamante S, Jayasena T, Richani D, Gilchrist RB, Wu LE, Sinclair DA, Sachdev PS, Braidy N. Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach. Metabolomics : Official Journal of the Metabolomic Society. 14: 15. PMID 30830318 DOI: 10.1007/S11306-017-1310-Z  0.195
2018 Delaquis S, Jewell M, Ostrovskiy I, Weber M, Ziegler T, Dalmasson J, Kaufman L, Richards T, Albert J, Anton G, Badhrees I, Barbeau P, Bayerlein R, Beck D, Belov V, ... Sinclair D, et al. Deep neural networks for energy and position reconstruction in EXO-200 Journal of Instrumentation. 13: P08023-P08023. DOI: 10.1088/1748-0221/13/08/P08023  0.194
2016 Means AR, Burns P, Sinclair D, Walson JL. Antihelminthics in helminth-endemic areas: effects on HIV disease progression. The Cochrane Database of Systematic Reviews. 4: CD006419. PMID 27075622 DOI: 10.1002/14651858.Cd006419.Pub4  0.194
2011 Lahti T, Methuen T, Roine R, Seppä KL, Sinclair D, Partinen M, Alho H. The impacts of nitrous oxide gas on sleep quality during alcohol withdrawal. Bmc Research Notes. 4: 108. PMID 21470436 DOI: 10.1186/1756-0500-4-108  0.194
2023 Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, ... ... Sinclair DA, et al. Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study. The Journal of Clinical Endocrinology and Metabolism. PMID 36740954 DOI: 10.1210/clinem/dgad027  0.194
2013 Brunner T, Fudenberg D, Sabourov A, Varentsov VL, Gratta G, Sinclair D. A setup for Ba-ion extraction from high pressure Xe gas for double-beta decay studies with EXO Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions With Materials and Atoms. 317: 473-475. DOI: 10.1016/J.Nimb.2013.05.086  0.193
2013 Sinclair D, Isba R, Kredo T, Zani B, Smith H, Garner P. Correction: World Health Organization Guideline Development: An Evaluation. Plos One. 8. DOI: 10.1371/Annotation/Fd04E7C6-0D40-4D2C-A382-C5Ad10074C99  0.193
2019 Lautrup S, Sinclair DA, Mattson MP, Fang EF. NAD in Brain Aging and Neurodegenerative Disorders. Cell Metabolism. 30: 630-655. PMID 31577933 DOI: 10.1016/j.cmet.2019.09.001  0.193
2015 Garg N, Sinclair DA. Oogonial stem cells as a model to study age-associated infertility in women. Reproduction, Fertility, and Development. PMID 25897831 DOI: 10.1071/RD14461  0.193
2017 Tickell-Painter M, Maayan N, Saunders R, Pace C, Sinclair D. Mefloquine for preventing malaria during travel to endemic areas. The Cochrane Database of Systematic Reviews. 10: CD006491. PMID 29083100 DOI: 10.1002/14651858.Cd006491.Pub4  0.193
2017 Albert JB, Barbeau PS, Beck D, Belov V, Breidenbach M, Brunner T, Burenkov A, Cao GF, Cen WR, Chambers C, Cleveland B, Coon M, Craycraft A, Daniels T, Danilov M, ... Sinclair D, et al. Measurement of the drift velocity and transverse diffusion of electrons in liquid xenon with the EXO-200 detector Physical Review C. 95: 25502. DOI: 10.1103/Physrevc.95.025502  0.191
2011 Dobi A, Hall C, Herrin S, Odian A, Prescott CY, Rowson PC, Ackerman N, Aharmin B, Auger M, Barbeau PS, Barry K, Benitez-Medina C, Breidenbach M, Cook S, Counts I, ... Sinclair D, et al. A xenon gas purity monitor for EXO Nuclear Instruments and Methods in Physics Research, Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 659: 215-228. DOI: 10.1016/J.Nima.2011.09.017  0.191
2010 Gogtay N, Brand F, Olliaro P, Sinclair D. Artemisinin‐based combination therapy for the treatment of uncomplicated Plasmodium vivax malaria and the prevention of relapses Cochrane Database of Systematic Reviews. DOI: 10.1002/14651858.Cd008492  0.19
1940 Sinclair D. A small high intensity stroboscopic source Review of Scientific Instruments. 11: 109. DOI: 10.1063/1.1751653  0.19
2009 Aharmim B, Cleveland BT, Dai X, Doucas G, Farine J, Fergani H, Ford R, Hahn RL, Hallman ED, Jelley NA, Lange R, Majerus S, Mifflin C, Noble AJ, O'Keeffe HM, ... Sinclair D, et al. High sensitivity measurement of 224Ra and 226Ra in water with an improved hydrous titanium oxide technique at the Sudbury Neutrino Observatory Nuclear Instruments and Methods in Physics Research, Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 604: 531-535. DOI: 10.1016/J.Nima.2009.01.227  0.19
2007 Alho H, Sinclair D, Vuori E, Holopainen A. Abuse liability of buprenorphine-naloxone tablets in untreated IV drug users. Drug and Alcohol Dependence. 88: 75-78. PMID 17055191 DOI: 10.1016/J.Drugalcdep.2006.09.012  0.19
2013 Sinclair DA. Studying the replicative life span of yeast cells. Methods in Molecular Biology (Clifton, N.J.). 1048: 49-63. PMID 23929097 DOI: 10.1007/978-1-62703-556-9_5  0.189
2007 Sinclair D, Komaroff AL. Can we slow aging? Newsweek. 148: 80, 82, 84. PMID 17186892  0.189
1990 Sinclair D. Only winning battles, but hoping to win the war. Objectives of radical antivivisectionists? Trends in Pharmacological Sciences. 11: 230. PMID 2382307 DOI: 10.1016/0165-6147(90)90248-7  0.188
2009 Neilson R, LePort F, Pocar A, Kumar KS, Odian A, Prescott CY, Tenev V, Ackerman N, Akimov D, Auger M, Benitez-Medina C, Breidenbach M, Burenkov A, Conley R, Cook S, ... Sinclair D, et al. Characterization of large area APDs for the EXO-200 detector Nuclear Instruments and Methods in Physics Research, Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 608: 68-75. DOI: 10.1016/J.Nima.2009.06.029  0.188
2015 Albert JB, Auty DJ, Barbeau PS, Beck D, Belov V, Breidenbach M, Brunner T, Burenkov A, Cao GF, Chambers C, Cleveland B, Coon M, Craycraft A, Daniels T, Danilov M, ... Sinclair D, et al. Measurements of the ion fraction and mobility of α- And β -decay products in liquid xenon using the EXO-200 detector Physical Review C - Nuclear Physics. 92. DOI: 10.1103/Physrevc.92.045504  0.188
2012 Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, Horvath TL, Sinclair DA, Pfluger PT, Tschöp MH. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiological Reviews. 92: 1479-514. PMID 22811431 DOI: 10.1152/Physrev.00022.2011  0.187
1931 Webb HW, Sinclair D. Recombination in mercury vapor Physical Review. 37: 182-193. DOI: 10.1103/Physrev.37.182  0.187
2017 Sinclair D, Jullien S, Garner P. Development economics-time to improve research methods. International Journal of Epidemiology. PMID 28161711 DOI: 10.1093/Ije/Dyw358  0.187
2011 LePort F, Neilson R, Barbeau PS, Barry K, Bartoszek L, Counts I, Davis J, deVoe R, Dolinski MJ, Gratta G, Green M, Montero Díez M, Müller AR, O'Sullivan K, Rivas A, ... Sinclair D, et al. A magnetically driven piston pump for ultra-clean applications. The Review of Scientific Instruments. 82: 105114. PMID 22047336 DOI: 10.1063/1.3653391  0.186
2007 Li Y, Yokota T, Gama V, Yoshida T, Gomez JA, Ishikawa K, Sasaguri H, Cohen HY, Sinclair DA, Mizusawa H, Matsuyama S. Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation. Cell Death and Differentiation. 14: 2058-67. PMID 17885668 DOI: 10.1038/sj.cdd.4402219  0.185
2022 Bischof E, Maier AB, Lee KF, Zhavoronkov A, Sinclair D. Advanced pathological ageing should be represented in the ICD. The Lancet. Healthy Longevity. 3: e12. PMID 36098284 DOI: 10.1016/S2666-7568(21)00303-2  0.184
2016 Mason-Jones AJ, Sinclair D, Mathews C, Kagee A, Hillman A, Lombard C. School-based interventions for preventing HIV, sexually transmitted infections, and pregnancy in adolescents. The Cochrane Database of Systematic Reviews. 11: CD006417. PMID 27824221 DOI: 10.1002/14651858.Cd006417.Pub3  0.184
2020 Schultz MB, Kane AE, Mitchell SJ, MacArthur MR, Warner E, Vogel DS, Mitchell JR, Howlett SE, Bonkowski MS, Sinclair DA. Age and life expectancy clocks based on machine learning analysis of mouse frailty. Nature Communications. 11: 4618. PMID 32934233 DOI: 10.1038/S41467-020-18446-0  0.183
2009 Blagosklonny MV, Campisi J, Sinclair DA. Aging: past, present and future. Aging. 1: 1-5. PMID 20157590 DOI: 10.18632/aging.100009  0.182
2016 Roberts DJ, Rylands J, Sinclair D. Interventions using mobile devices (phones, smart phones, or tablets) to improve adherence to treatment for HIV or tuberculosis Cochrane Database of Systematic Reviews. 2016. DOI: 10.1002/14651858.Cd012353  0.182
2020 Mueller AL, McNamara MS, Sinclair DA. Why does COVID-19 disproportionately affect older people? Aging. 12: 9959-9981. PMID 32470948 DOI: 10.18632/aging.103344  0.182
1962 Sinclair D. Perineal Ice-packs British Medical Journal. 2: 1473. DOI: 10.1136/Bmj.2.5317.1473  0.181
1936 Sinclair D, Webb HW. Lifetimes of potassium doublets λ4047-4 and λ3447-6 Physical Review. 50: 440-445. DOI: 10.1103/Physrev.50.440  0.18
2014 Brunner T, Fudenberg D, Varentsov V, Sabourov A, Gratta G, Dilling J, DeVoe R, Sinclair D, Fairbank W, Albert JB, Auty DJ, Barbeau PS, Beck D, Benitez-Medina C, Breidenbach M, et al. An RF-only ion-funnel for extraction from high-pressure gases International Journal of Mass Spectrometry. DOI: 10.1016/J.Ijms.2015.01.003  0.179
1989 McSharry C, Galloway E, Sinclair D. Serum paraproteins in osteoporosis Bmj. 299: 1164-1164. DOI: 10.1136/Bmj.299.6708.1164-B  0.179
2022 Osborne B, Reznick J, Wright LE, Sinclair DA, Cooney GJ, Turner N. Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice. Biochemical and Biophysical Research Communications. 607: 131-137. PMID 35367825 DOI: 10.1016/j.bbrc.2022.03.088  0.178
2016 Kliner M, Keenan A, Sinclair D, Ghebrehewet S, Garner P. Influenza vaccination for healthcare workers in the UK: appraisal of systematic reviews and policy options. Bmj Open. 6: e012149. PMID 27625062 DOI: 10.1136/Bmjopen-2016-012149  0.176
2019 Baur JA, Sinclair DA. What is Xenohormesis? American Journal of Pharmacology and Toxicology. 3: 152-159. PMID 26949380 DOI: 10.3844/ajptsp.2008.152.159  0.176
2016 Schultz MB, Sinclair DA. When stem cells grow old: phenotypes and mechanisms of stem cell aging. Development (Cambridge, England). 143: 3-14. PMID 26732838 DOI: 10.1242/dev.130633  0.176
2019 Palmeira CM, Teodoro JS, Amorim JA, Steegborn C, Sinclair DA, Rolo AP. Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins. Free Radical Biology & Medicine. 141: 483-491. PMID 31349039 DOI: 10.1016/j.freeradbiomed.2019.07.017  0.175
2023 Kim LJ, Chalmers TJ, Madawala R, Smith GC, Li C, Das A, Poon EWK, Wang J, Tucker SP, Sinclair DA, Quek LE, Wu LE. Host-microbiome interactions in nicotinamide mononucleotide (NMN) deamidation. Febs Letters. PMID 37463842 DOI: 10.1002/1873-3468.14698  0.174
1998 Kiianmaa K, Sinclair D. Olof Forsander (1918–1997) Alcohol and Alcoholism. 33: 193-194. DOI: 10.1093/Oxfordjournals.Alcalc.A008381  0.172
2016 Wu LE, Sinclair DA. Restoring stem cells - all you need is NAD(.) Cell Research. PMID 27339086 DOI: 10.1038/cr.2016.80  0.172
2022 Zheng M, Schultz MB, Sinclair DA. NAD in COVID-19 and viral infections. Trends in Immunology. PMID 35221228 DOI: 10.1016/j.it.2022.02.001  0.172
2016 Abdesselem H, Madani A, Hani A, Al-Noubi M, Goswami N, Ben Hamidane H, Billing AM, Pasquier J, Bonkowski MS, Halabi N, Dalloul R, Sheriff MZ, Mesaeli N, ElRayess M, Sinclair DA, et al. SIRT1 Limits Adipocyte Hyperplasia through c-Myc Inhibition. The Journal of Biological Chemistry. 291: 2119-35. PMID 26655722 DOI: 10.1074/Jbc.M115.675645  0.172
2005 Mai A, Massa S, Lavu S, Pezzi R, Simeoni S, Ragno R, Mariotti FR, Chiani F, Camilloni G, Sinclair DA. Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. Journal of Medicinal Chemistry. 48: 7789-95. PMID 16302818 DOI: 10.1021/Jm050100L  0.171
2001 Cohen H, Sinclair DA. Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase. Proceedings of the National Academy of Sciences of the United States of America. 98: 3174-9. PMID 11248051 DOI: 10.1073/pnas.061579598  0.171
2015 Gomes AP, Sinclair DA. Measuring PGC-1α and its acetylation status in mouse primary myotubes. Methods in Molecular Biology (Clifton, N.J.). 1241: 49-57. PMID 25308487 DOI: 10.1007/978-1-4939-1875-1_5  0.169
2018 Schultz MB, Lu Y, Braidy N, Sinclair DA. Assays for NAD-Dependent Reactions and NAD Metabolites. Methods in Molecular Biology (Clifton, N.J.). 1813: 77-90. PMID 30097862 DOI: 10.1007/978-1-4939-8588-3_6  0.166
2015 Riepsamen A, Wu L, Lau L, Listijono D, Ledger W, Sinclair D, Homer H. Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes. Plos One. 10: e0126194. PMID 25938585 DOI: 10.1371/journal.pone.0126194  0.166
1994 Sinclair DA, Kornfeld GD, Dawes IW. Yeast intragenic transcriptional control: activation and repression sites within the coding region of the Saccharomyces cerevisiae LPD1 gene. Molecular and Cellular Biology. 14: 214-25. PMID 8264590 DOI: 10.1128/MCB.14.1.214  0.165
2006 Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nature Reviews. Drug Discovery. 5: 493-506. PMID 16732220 DOI: 10.1038/nrd2060  0.164
1999 Hong SP, Piper MD, Sinclair DA, Dawes IW. Control of expression of one-carbon metabolism genes of Saccharomyces cerevisiae is mediated by a tetrahydrofolate-responsive protein binding to a glycine regulatory region including a core 5'-CTTCTT-3' motif Journal of Biological Chemistry. 274: 10523-10532. PMID 10187845 DOI: 10.1074/jbc.274.15.10523  0.163
2023 Karg MM, Lu YR, Refaian N, Cameron J, Hoffmann E, Hoppe C, Shirahama S, Shah M, Krasniqi D, Krishnan A, Shrestha M, Guo Y, Cermak JM, Walthier M, Broniowska K, ... ... Sinclair DA, et al. Sustained Vision Recovery by OSK Gene Therapy in a Mouse Model of Glaucoma. Cellular Reprogramming. 25: 288-299. PMID 38060815 DOI: 10.1089/cell.2023.0074  0.163
1996 Sinclair DA, Hong SP, Dawes IW. Specific induction by glycine of the gene for the P-subunit of glycine decarboxylase from Saccharomyces cerevisiae. Molecular Microbiology. 19: 611-23. PMID 8830251 DOI: 10.1046/j.1365-2958.1996.419947.x  0.161
2021 Amorim JA, Sinclair DA. Measuring PGC-1α and Its Acetylation Status in Mouse Primary Myotubes. Methods in Molecular Biology (Clifton, N.J.). 2310: 301-309. PMID 34096010 DOI: 10.1007/978-1-0716-1433-4_17  0.159
2015 Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, et al. Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. Nature Communications. 6: 6263. PMID 25672491 DOI: 10.1038/Ncomms7263  0.158
2011 Vendrell A, Martínez-Pastor M, González-Novo A, Pascual-Ahuir A, Sinclair DA, Proft M, Posas F. Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase. Embo Reports. 12: 1062-8. PMID 21836634 DOI: 10.1038/embor.2011.154  0.158
2020 Chen X, Amorim JA, Moustafa GA, Lee JJ, Yu Z, Ishihara K, Iesato Y, Barbisan P, Ueta T, Togka KA, Lu L, Sinclair DA, Vavvas DG. Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment. Aging. 12. PMID 33373320 DOI: 10.18632/aging.202453  0.152
2016 Prola A, Silva JP, Guilbert A, Lecru L, Piquereau J, Ribeiro M, Mateo P, Gressette M, Fortin D, Boursier C, Gallerne C, Caillard A, Samuel JL, François H, Sinclair DA, et al. SIRT1 protects the heart from ER stress-induced cell death through eIF2α deacetylation. Cell Death and Differentiation. PMID 27911441 DOI: 10.1038/cdd.2016.138  0.151
2014 Solon-Biet SM, McMahon AC, Ballard JW, Ruohonen K, Wu LE, Cogger VC, Warren A, Huang X, Pichaud N, Melvin RG, Gokarn R, Khalil M, Turner N, Cooney GJ, Sinclair DA, et al. The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice. Cell Metabolism. 19: 418-30. PMID 24606899 DOI: 10.1016/J.Cmet.2014.02.009  0.15
2013 Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN. Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. 62: 1084-93. PMID 23172919 DOI: 10.2337/db12-1139  0.149
2015 Miranda MX, van Tits LJ, Lohmann C, Arsiwala T, Winnik S, Tailleux A, Stein S, Gomes AP, Suri V, Ellis JL, Lutz TA, Hottiger MO, Sinclair DA, Auwerx J, Schoonjans K, et al. The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression. European Heart Journal. 36: 51-9. PMID 24603306 DOI: 10.1093/eurheartj/ehu095  0.148
2013 Lai L, Yan L, Gao S, Hu CL, Ge H, Davidow A, Park M, Bravo C, Iwatsubo K, Ishikawa Y, Auwerx J, Sinclair DA, Vatner SF, Vatner DE. Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway. Circulation. 127: 1692-701. PMID 23536361 DOI: 10.1161/CIRCULATIONAHA.112.001212  0.148
2020 Lauc G, Sinclair D. Biomarkers of biological age as predictors of COVID-19 disease severity. Aging. PMID 32268300 DOI: 10.18632/aging.103052  0.147
2016 Cagnone GL, Tsai TS, Makanji Y, Matthews P, Gould J, Bonkowski MS, Elgass KD, Wong AS, Wu LE, McKenzie M, Sinclair DA, John JC. Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency. Scientific Reports. 6: 23229. PMID 26987907 DOI: 10.1038/Srep23229  0.147
2017 Costford SR, Brouwers B, Hopf ME, Sparks LM, Dispagna M, Gomes AP, Cornnell HH, Petucci C, Phelan P, Xie H, Yi F, Walter GA, Osborne TF, Sinclair DA, Mynatt RL, et al. Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance. Molecular Metabolism. PMID 29146412 DOI: 10.1016/J.Molmet.2017.10.012  0.146
2023 Rizzo JF, Shah MP, Krasniqi D, Lu YR, Sinclair DA, Ksander BR. The Role of Epigenetics in Accelerated Aging: A Reconsideration of Later-Life Visual Loss After Early Optic Neuropathy. Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society. PMID 37938114 DOI: 10.1097/WNO.0000000000002041  0.146
2022 Bosch JA, Ugur B, Pichardo-Casas I, Rabasco J, Escobedo F, Zuo Z, Brown B, Celniker S, Sinclair DA, Bellen HJ, Perrimon N. Two neuronal peptides encoded from a single transcript regulate mitochondrial complex III in . Elife. 11. PMID 36346220 DOI: 10.7554/eLife.82709  0.146
2020 Uddin GM, Youngson NA, Chowdhury SS, Hagan C, Sinclair DA, Morris MJ. Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers. Cells. 9. PMID 32218167 DOI: 10.3390/cells9040791  0.144
2013 Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, et al. Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 6-16. PMID 22451473 DOI: 10.1093/Gerona/Gls070  0.144
2020 Jalal H, Buchanich JM, Sinclair DR, Roberts MS, Burke DS. Age and generational patterns of overdose death risk from opioids and other drugs. Nature Medicine. 26: 699-704. PMID 32367060 DOI: 10.1038/s41591-020-0855-y  0.142
2016 Ferrer CM, Lu TY, Bacigalupa ZA, Katsetos CD, Sinclair DA, Reginato MJ. O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway. Oncogene. PMID 27345396 DOI: 10.1038/Onc.2016.228  0.141
2020 Teodoro JS, Amorim JA, Machado IF, Castela AC, Steegborn C, Sinclair DA, Rolo AP, Palmeira CM. The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function. International Journal of Molecular Sciences. 21. PMID 32664470 DOI: 10.3390/ijms21144896  0.141
2023 Maharani A, Sinclair DR, Chandola T, Bower P, Clegg A, Hanratty B, Nazroo J, Pendleton N, Tampubolon G, Todd C, Wittenberg R, O'Neill TW, Matthews FE. Household wealth, neighbourhood deprivation and frailty amongst middle-aged and older adults in England: a longitudinal analysis over 15 years (2002-2017). Age and Ageing. 52. PMID 36995138 DOI: 10.1093/ageing/afad034  0.141
2016 Anderson EN, Corkins ME, Li JC, Singh K, Parsons S, Tucey TM, Sorkaç A, Huang H, Dimitriadi M, Sinclair DA, Hart AC. C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins. Mechanisms of Ageing and Development. PMID 26854551 DOI: 10.1016/J.Mad.2016.01.004  0.139
2018 Mitchell SJ, Bernier M, Aon MA, Cortassa S, Kim EY, Fang EF, Palacios HH, Ali A, Navas-Enamorado I, Di Francesco A, Kaiser TA, Waltz TB, Zhang N, Ellis JL, Elliott PJ, ... ... Sinclair DA, et al. Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice. Cell Metabolism. 27: 667-676.e4. PMID 29514072 DOI: 10.1016/J.Cmet.2018.02.001  0.139
2018 Wahl D, Solon-Biet SM, Wang QP, Wali JA, Pulpitel T, Clark X, Raubenheimer D, Senior AM, Sinclair DA, Cooney GJ, de Cabo R, Cogger VC, Simpson SJ, Le Couteur DG. Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. Cell Reports. 25: 2234-2243.e6. PMID 30463018 DOI: 10.1016/j.celrep.2018.10.070  0.138
2021 Kato T, Liu N, Morinaga H, Asakawa K, Muraguchi T, Muroyama Y, Shimokawa M, Matsumura H, Nishimori Y, Tan LJ, Hayano M, Sinclair DA, Mohri Y, Nishimura EK. Dynamic stem cell selection safeguards the genomic integrity of the epidermis. Developmental Cell. 56: 3309-3320.e5. PMID 34932948 DOI: 10.1016/j.devcel.2021.11.018  0.137
2017 Pollack RM, Barzilai N, Anghel V, Kulkarni AS, Golden A, O'Broin P, Sinclair DA, Bonkowski MS, Coleville AJ, Powell D, Kim S, Moaddel R, Stein D, Zhang K, Hawkins M, et al. Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 28329397 DOI: 10.1093/Gerona/Glx041  0.136
2020 Schultz MB, Kane AE, Mitchell SJ, MacArthur MR, Warner E, Vogel DS, Mitchell JR, Howlett SE, Bonkowski MS, Sinclair DA. Publisher Correction: Age and life expectancy clocks based on machine learning analysis of mouse frailty. Nature Communications. 11: 5143. PMID 33033247 DOI: 10.1038/s41467-020-19046-8  0.135
2023 Drake SS, Mohammadnia A, Heale K, Groh AMR, Hua EM, Zaman A, Hintermayer MA, Zandee S, Gosselin D, Stratton JA, Sinclair DA, Fournier AE. Cellular rejuvenation protects neurons from inflammation mediated cell death. Biorxiv : the Preprint Server For Biology. PMID 37873446 DOI: 10.1101/2023.09.30.560301  0.133
2007 Sinclair D. Listening to the socially excluded: the European national action plan British Journal of Community Nursing. 12: 571-573. PMID 18361176  0.132
2024 Cipriano A, Moqri M, Maybury-Lewis SY, Rogers-Hammond R, de Jong TA, Parker A, Rasouli S, Schöler HR, Sinclair DA, Sebastiano V. Publisher Correction: Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming. Nature Aging. PMID 38177331 DOI: 10.1038/s43587-023-00562-3  0.132
2020 Montay-Gruel P, Zhu Y, Petit B, Leavitt R, Warn M, Giedzinski E, Ollivier J, Sinclair DA, Vozenin MC, Limoli CL. Extracellular Vesicles for the Treatment of Radiation-Induced Normal Tissue Toxicity in the Lung. Frontiers in Oncology. 10: 602763. PMID 33738245 DOI: 10.3389/fonc.2020.602763  0.13
2023 Turrini S, Wong B, Eldaief M, Press D, Sinclair DA, Koch G, Avenanti A, Santarnecchi E. The multifactorial nature of healthy brain ageing: brain changes, functional decline and protective factors. Ageing Research Reviews. 101939. PMID 37116664 DOI: 10.1016/j.arr.2023.101939  0.129
2015 Zhang QS, Deater M, Schubert K, Marquez-Loza L, Pelz C, Sinclair DA, Grompe M. The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice. Stem Cell Research. 15: 130-40. PMID 26046330 DOI: 10.1016/j.scr.2015.05.007  0.128
2020 Solon-Biet SM, McMahon AC, Ballard JWO, Ruohonen K, Wu LE, Cogger VC, Warren A, Huang X, Pichaud N, Melvin RG, Gokarn R, Khalil M, Turner N, Cooney GJ, Sinclair DA, et al. The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice. Cell Metabolism. 31: 654. PMID 32130886 DOI: 10.1016/J.Cmet.2020.01.010  0.127
2018 Teodoro JS, Amorim JA, Silva R, Rolo AP, Steegborn C, Sinclair DA, Palmeira CM. Sirtuin- cAMP crosstalk in metabolic diseases: nucleus versus mitochondria Free Radical Biology and Medicine. 120: S160. DOI: 10.1016/j.freeradbiomed.2018.04.526  0.126
2022 Mach J, Kane AE, Howlett SE, Sinclair DA, Hilmer SN. Applying the AFRAID and FRIGHT clocks to novel preclinical mouse models of polypharmacy. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 35313348 DOI: 10.1093/gerona/glac067  0.122
2021 Sinclair DR, Maharani A, Stow D, Welsh CE, Matthews FE. Can vaccination roll-out be more equitable if population risk is taken into account? Plos One. 16: e0259990. PMID 34780553 DOI: 10.1371/journal.pone.0259990  0.122
2022 Li A, Mueller A, English B, Arena A, Vera D, Kane AE, Sinclair DA. Novel feature selection methods for construction of accurate epigenetic clocks. Plos Computational Biology. 18: e1009938. PMID 35984867 DOI: 10.1371/journal.pcbi.1009938  0.12
2024 Yang JH, Hayano M, Rajman LA, Sinclair DA. Response to: The information theory of aging has not been tested. Cell. 187: 1103-1105. PMID 38428391 DOI: 10.1016/j.cell.2024.01.014  0.119
2022 Tran T, Pencina KM, Schultz MB, Li Z, Ghattas C, Lau J, Sinclair DA, Montano M. Reduced Levels of NAD in Skeletal Muscle and Increased Physiologic Frailty Are Associated With Viral Coinfection in Asymptomatic Middle-Aged Adults. Journal of Acquired Immune Deficiency Syndromes (1999). 89: S15-S22. PMID 35015741 DOI: 10.1097/QAI.0000000000002852  0.119
2014 Michan S, Juan AM, Hurst CG, Cui Z, Evans LP, Hatton CJ, Pei DT, Ju M, Sinclair DA, Smith LE, Chen J. Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy. Plos One. 9: e85031. PMID 24416337 DOI: 10.1371/Journal.Pone.0085031  0.119
2016 Mohamad M, Mitchell SJ, Wu LE, White MY, Cordwell SJ, Mach J, Solon-Biet SM, Boyer D, Nines D, Das A, Catherine Li SY, Warren A, Hilmer SN, Fraser R, Sinclair DA, et al. Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance. Aging Cell. PMID 27095270 DOI: 10.1111/Acel.12481  0.118
2017 Hugo C, Isenring E, Sinclair D, Agarwal E. What does it cost to feed aged care residents in Australia? Nutrition & Dietetics: the Journal of the Dietitians Association of Australia. PMID 28741752 DOI: 10.1111/1747-0080.12368  0.117
2018 Bonora M, Wieckowski MR, Sinclair DA, Kroemer G, Pinton P, Galluzzi L. Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles. Nature Reviews. Cardiology. PMID 30177752 DOI: 10.1038/S41569-018-0074-0  0.116
2019 Montano M, Bhasin S, D'Aquila RT, Erlandson KM, Evans WJ, Funderburg NT, Justice A, Ndhlovu LC, Ojikutu B, Pahor M, Pahwa S, Ryan AS, Schrack J, Schultz M, Sebastiani P, ... Sinclair DA, et al. HARVARD HIV AND AGING WORKSHOP: PERSPECTIVES AND PRIORITIES FROM CLAUDE D. PEPPER CENTERS AND CENTERS FOR AIDS RESEARCH. Aids Research and Human Retroviruses. PMID 31456412 DOI: 10.1089/Aid.2019.0130  0.115
2020 Palliyaguru DL, Minor RK, Mitchell SJ, Palacio HH, Licata JJ, Ward TM, Abulwerdi G, Elliott P, Westphal C, Ellis JL, Sinclair DA, Price NL, Bernier M, de Cabo R. Combining a high dose of metformin with the SIRT1 activator, SRT1720, reduces lifespan in aged mice fed a high-fat diet. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 32556267 DOI: 10.1093/Gerona/Glaa148  0.115
2011 Ramadori G, Fujikawa T, Anderson J, Berglund ED, Frazao R, Michán S, Vianna CR, Sinclair DA, Elias CF, Coppari R. SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. Cell Metabolism. 14: 301-12. PMID 21907137 DOI: 10.1016/J.Cmet.2011.06.014  0.112
2015 Sinclair D. The coalition government and ageing policy: A critique Quality in Ageing and Older Adults. 16: 3-13. DOI: 10.1108/QAOA-11-2014-0033  0.111
2018 Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, ... ... Sinclair DA, et al. Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and HS Production. Cell. 173: 117-129.e14. PMID 29570992 DOI: 10.1016/J.Cell.2018.03.001  0.11
2016 Uddin GM, Youngson NA, Sinclair DA, Morris MJ. Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice. Frontiers in Pharmacology. 7: 258. PMID 27594836 DOI: 10.3389/fphar.2016.00258  0.108
2019 Youngson NA, Uddin GM, Das A, Martinez C, Connaughton HS, Whiting S, Yu J, Sinclair DA, Aitken RJ, Morris MJ. Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice. Reproduction (Cambridge, England). 158: 171-181. PMID 31226694 DOI: 10.1530/Rep-18-0574  0.108
2017 Uddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ. Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise. Scientific Reports. 7: 15063. PMID 29118320 DOI: 10.1038/s41598-017-14866-z  0.105
2012 Sinclair DB. Jewish Biomedical Law: Legal and Extra-Legal Dimensions Jewish Biomedical Law: Legal and Extra-Legal Dimensions. 1-304. DOI: 10.1093/acprof:oso/9780198268277.001.0001  0.105
2014 Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN. Flavonoid apigenin is an inhibitor of the NAD+ase CD38: Implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome (Diabetes (2013) 62 (1084-1093)) Diabetes. 63: 1428. DOI: 10.2337/db14-er04  0.105
2019 Kane AE, Sinclair DA. Frailty biomarkers in humans and rodents: current approaches and future advances. Mechanisms of Ageing and Development. PMID 31002925 DOI: 10.1016/j.mad.2019.03.007  0.105
2008 Howitz KT, Sinclair DA. Xenohormesis: sensing the chemical cues of other species. Cell. 133: 387-91. PMID 18455976 DOI: 10.1016/j.cell.2008.04.019  0.105
2022 Guo AH, Baliira R, Skinner ME, Kumar S, Andren A, Zhang L, Goldsmith RS, Michan S, Davis NJ, Maccani MW, Day SM, Sinclair DA, Brody MJ, Lyssiotis CA, Stein AB, et al. Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload. Scientific Reports. 12: 12258. PMID 35851833 DOI: 10.1038/s41598-022-16506-7  0.105
2007 Calabrese EJ, Bachmann KA, Bailer AJ, Bolger PM, Borak J, Cai L, Cedergreen N, Cherian MG, Chiueh CC, Clarkson TW, Cook RR, Diamond DM, Doolittle DJ, Dorato MA, Duke SO, ... ... Sinclair DA, et al. Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework. Toxicology and Applied Pharmacology. 222: 122-8. PMID 17459441 DOI: 10.1016/J.Taap.2007.02.015  0.105
2012 Nakamura K, Kosugi I, Lee DY, Hafner A, Sinclair DA, Ryo A, Lu KP. Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin. Molecular and Cellular Biology. 32: 2966-78. PMID 22645310 DOI: 10.1128/Mcb.05688-11  0.103
2010 Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, ... Sinclair DA, et al. SIRT1 is essential for normal cognitive function and synaptic plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9695-707. PMID 20660252 DOI: 10.1523/Jneurosci.0027-10.2010  0.101
2014 Cronise RJ, Sinclair DA, Bremer AA. The "metabolic winter" hypothesis: a cause of the current epidemics of obesity and cardiometabolic disease. Metabolic Syndrome and Related Disorders. 12: 355-61. PMID 24918620 DOI: 10.1089/met.2014.0027  0.099
2012 Lahti T, Halme JT, Pankakoski M, Sinclair D, Alho H. Treatment of pathological gambling with naltrexone pharmacotherapy and brief intervention: a pilot study. Psychopharmacology Bulletin. 43: 35-44. PMID 21150845  0.098
2018 Kane AE, Sinclair DA, Mitchell JR, Mitchell SJ. Sex differences in the response to dietary restriction in rodents. Current Opinion in Physiology. 6: 28-34. PMID 31231711 DOI: 10.1016/j.cophys.2018.03.008  0.097
2013 Chen J, Michan S, Juan AM, Hurst CG, Hatton CJ, Pei DT, Joyal JS, Evans LP, Cui Z, Stahl A, Sapieha P, Sinclair DA, Smith LE. Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. Angiogenesis. 16: 985-92. PMID 23912262 DOI: 10.1007/S10456-013-9374-5  0.096
2023 Osborne B, Wright LE, Brandon AE, Stuart E, Small L, Hoeks J, Schrauwen P, Sinclair DA, Montgomery MK, Cooney GJ, Turner N. SIRT3 overexpression in rat muscle does not ameliorate peripheral insulin resistance. The Journal of Endocrinology. PMID 37335200 DOI: 10.1530/JOE-22-0101  0.094
2003 Sinclair D. IgD myeloma: clinical, biological and laboratory features. Clinical Laboratory. 48: 617-22. PMID 12465746  0.092
2020 Leis AA, Grill MF, Goodman BP, Sadiq SB, Sinclair DJ, Vig PJS, Bai F. Tumor Necrosis Factor-Alpha Signaling May Contribute to Chronic West Nile Virus Post-infectious Proinflammatory State. Frontiers in Medicine. 7: 164. PMID 32426358 DOI: 10.3389/fmed.2020.00164  0.092
2014 Fillman SG, Sinclair D, Fung SJ, Webster MJ, Shannon Weickert C. Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder. Translational Psychiatry. 4: e365. PMID 24569695 DOI: 10.1038/tp.2014.8  0.09
2024 Valeri J, Stiplosek C, O'Donovan SM, Sinclair D, Grant KA, Bollavarapu R, Platt DM, Stockmeier CA, Gisabella B, Pantazopoulos H. Extracellular matrix abnormalities in the hippocampus of subjects with substance use disorder. Translational Psychiatry. 14: 115. PMID 38402197 DOI: 10.1038/s41398-024-02833-y  0.09
2016 Cronise RJ, Sinclair DA, Bremer AA. Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease. Metabolic Syndrome and Related Disorders. PMID 27869525 DOI: 10.1089/met.2016.0108  0.09
2010 Rutanen J, Yaluri N, Modi S, Pihlajamäki J, Vänttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, Sinclair DA, Elliott P, Westphal C, Auwerx J, Laakso M. SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity. Diabetes. 59: 829-35. PMID 20107110 DOI: 10.2337/db09-1191  0.09
2014 Uddin GM, Youngson N, Sinclair DA, Morris M. Impaired blood glucose clearance and mitochondrial function induced by high fat diet is improved by exercise and an ‘exercise mimetic’ Obesity Research & Clinical Practice. 8: 108. DOI: 10.1016/j.orcp.2014.10.195  0.089
2023 Valeri J, Stiplosek C, O'Donovan SM, Sinclair D, Grant KA, Bollavarapu R, Platt DM, Stockmeier CA, Gisabella B, Pantazopoulos H. Extracellular Matrix Abnormalities in the Hippocampus of Subjects with Substance Use Disorder. Medrxiv : the Preprint Server For Health Sciences. PMID 37732207 DOI: 10.1101/2023.09.07.23295222  0.089
2024 Davies LE, Spiers GF, Sinclair DR, Kingston A, Hanratty B. Characteristics of older unpaid carers in England: a study of social patterning from the English Longitudinal Study of Ageing. Age and Ageing. 53. PMID 38497238 DOI: 10.1093/ageing/afae049  0.087
2011 Accili D, de Cabo R, Sinclair DA. An unSIRTain role in longevity. Nature Medicine. 17: 1350-1. PMID 22064411 DOI: 10.1038/nm1111-1350  0.086
1971 Sinclair DK. Factorization of the balachandran dual-resonance model Physical Review D. 3: 384-394. DOI: 10.1103/PhysRevD.3.384  0.086
2019 Bulkin DA, Sinclair DG, Law LM, Smith DM. Hippocampal state transitions at the boundaries between trial epochs. Hippocampus. PMID 31793687 DOI: 10.1002/hipo.23180  0.084
2019 Leis AA, Sinclair DJ. Lazarus Effect of High Dose Corticosteroids in a Patient With West Nile Virus Encephalitis: A Coincidence or a Clue? Frontiers in Medicine. 6: 81. PMID 31106205 DOI: 10.3389/fmed.2019.00081  0.083
2002 Ralph CJ, Tanser SJ, Macnaughton PD, Sinclair DG. A randomised controlled trial investigating the effects of dopexamine on gastrointestinal function and organ dysfunction in the critically ill. Intensive Care Medicine. 28: 884-90. PMID 12122526 DOI: 10.1007/s00134-002-1322-6  0.082
2018 Westerman K, Reaver A, Roy C, Ploch M, Sharoni E, Nogal B, Sinclair DA, Katz DL, Blumberg JB, Blander G. Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects. Scientific Reports. 8: 14685. PMID 30279436 DOI: 10.1038/s41598-018-33008-7  0.081
2006 Sinclair D. Deleterious pleiotropic effects of the atypical aldehyde dehydrogenase 2 (ALDH2) allele: comment on Luo et al., 2005 Biochemical Genetics. 44: 385-390. PMID 17103300  0.08
2023 Alaghband Y, Klein PM, Kramár EA, Cranston MN, Perry BC, Shelerud LM, Kane AE, Doan NL, Ru N, Acharya MM, Wood MA, Sinclair DA, Dickstein DL, Soltesz I, Limoli CL, et al. Galactic cosmic radiation exposure causes multifaceted neurocognitive impairments. Cellular and Molecular Life Sciences : Cmls. 80: 29. PMID 36607431 DOI: 10.1007/s00018-022-04666-8  0.079
2017 Cronise RJ, Sinclair DA, Bremer AA. Response to: "If the Metabolic Winter Is Coming, When Will It Be Summer?" (Metab Syndr Relat Disord 2017;15:3). Metabolic Syndrome and Related Disorders. PMID 28165301 DOI: 10.1089/met.2017.0004  0.079
2005 Sinclair D, Wilde G, Bex S, Peters S. Complementing the patient: a complement component deficiency in a patient with recurrent infections and glomerulonephritis. Clinical Laboratory. 51: 505-7. PMID 16285472  0.078
2018 Bertoldo MJ, Uddin GM, Youngson NA, Agapiou D, Walters KA, Sinclair DA, Morris MJ, Gilchrist RB. Multigenerational obesity-induced perturbations in oocyte-secreted factor signalling can be ameliorated by exercise and nicotinamide mononucleotide. Human Reproduction Open. 2018: hoy010. PMID 30895251 DOI: 10.1093/hropen/hoy010  0.078
2011 Hua J, Guerin KI, Chen J, Michán S, Stahl A, Krah NM, Seaward MR, Dennison RJ, Juan AM, Hatton CJ, Sapieha P, Sinclair DA, Smith LE. Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. Investigative Ophthalmology & Visual Science. 52: 2809-16. PMID 21282584 DOI: 10.1167/Iovs.10-6496  0.077
2020 Schultz MB, Vera D, Sinclair DA. Can artificial intelligence identify effective COVID-19 therapies? Embo Molecular Medicine. e202012817. PMID 32569446 DOI: 10.15252/Emmm.202012817  0.076
2016 Mazerolle EL, Ma Y, Sinclair D, Pike GB. Impact of abnormal cerebrovascular reactivity on BOLD fMRI: a preliminary investigation of moyamoya disease. Clinical Physiology and Functional Imaging. PMID 27572110 DOI: 10.1111/Cpf.12387  0.076
2010 Le Couteur DG, Sinclair DA. A blueprint for developing therapeutic approaches that increase healthspan and delay death. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 65: 693-4. PMID 20375077 DOI: 10.1093/gerona/glq048  0.075
2011 Sinclair D, Abba K, Grobler L, Sudarsanam TD. Nutritional supplements for people being treated for active tuberculosis. The Cochrane Database of Systematic Reviews. CD006086. PMID 22071828 DOI: 10.1002/14651858.CD006086.pub3  0.073
2006 Sinclair D. Business matters Fire Prevention and Fire Engineers Journals.  0.072
2013 Al Hinai Q, Zeitouni A, Sirhan D, Sinclair D, Melancon D, Richardson J, Leblanc R. Communicating hydrocephalus and vestibular schwannomas: etiology, treatment, and long-term follow-up. Journal of Neurological Surgery. Part B, Skull Base. 74: 68-74. PMID 24436891 DOI: 10.1055/s-0033-1333621  0.072
2016 Abdesselem H, Madani A, Hani A, Al-Noubi M, Goswami N, Ben Hamidane H, Billing AM, Pasquier J, Bonkowski MS, Halabi N, Dalloul R, Sheriff MZ, Mesaeli N, ElRayess M, Sinclair DA, et al. SIRT1 limits adipocyte hyperplasia through c-Myc inhibition Journal of Biological Chemistry. 291: 2119-2135. DOI: 10.1074/jbc.M115.675645  0.072
2013 Qu BX, Gong Y, Sinclair D, Fu M, Perl D, Diaz-Arrastia R. cPLA2α knockout mice exhibit abnormalities in the architecture and synapses of cortical neurons. Brain Research. 1497: 101-5. PMID 23266724 DOI: 10.1016/J.Brainres.2012.12.018  0.072
2021 Martínez-Greene JA, Hernández-Ortega K, Quiroz-Baez R, Resendis-Antonio O, Pichardo-Casas I, Sinclair DA, Budnik B, Hidalgo-Miranda A, Uribe-Querol E, Ramos-Godínez MDP, Martínez-Martínez E. Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography. Journal of Extracellular Vesicles. 10: e12087. PMID 33936570 DOI: 10.1002/jev2.12087  0.071
2022 Charlton K, Sinclair DR, Hanratty B, Burrow E, Stow D. Measuring frailty and its association with key outcomes in the ambulance setting: a cross sectional observational study. Bmc Geriatrics. 22: 935. PMID 36471316 DOI: 10.1186/s12877-022-03633-z  0.07
1975 Eales JG, Sinclair DA. Enterohepatic cycling of thyroxine in starved and fed brook trout, Salvelinus fontinalis (Mitchill). Comparative Biochemistry and Physiology. a, Comparative Physiology. 49: 661-72. PMID 4138996 DOI: 10.1016/0300-9629(74)90894-9  0.07
2021 Sinclair DG, Hooker G. An expectation maximization algorithm for high-dimensional model selection for the Ising model with misclassified states. Journal of Applied Statistics. 49: 4049-4068. PMID 36353302 DOI: 10.1080/02664763.2021.1970121  0.068
2023 Davies LE, Todd A, Sinclair DR, Robinson L, Kingston A. Is polypharmacy associated with difficulty taking medicines in people aged ≥85 living at home? Findings from the Newcastle 85+ Study. British Journal of Clinical Pharmacology. PMID 37480194 DOI: 10.1111/bcp.15858  0.066
2015 Riepsamen A, Wu L, Lau L, Listijono D, Ledger W, Sinclair DA, Homer H. Correction: Nicotinamide Impairs Entry into and Exit from Meiosis I in Mouse Oocytes. Plos One. 10: e0130058. PMID 26038838 DOI: 10.1371/journal.pone.0130058  0.066
1984 Sinclair DF, Gleeson AC. On the analysis of replacement series diallel experiments The Journal of Agricultural Science. 102: 531-537. DOI: 10.1017/S002185960004209X  0.065
2018 Koniaris C, Kosek M, Sinclair D, Mitchell K. Compressed Animated Light Fields with Real-time View-dependent Reconstruction. Ieee Transactions On Visualization and Computer Graphics. PMID 29993780 DOI: 10.1109/Tvcg.2018.2818156  0.064
2019 Feng J, LaChance A, Sinclair DA, Asgari MM. Multiple basal cell carcinomas in a patient with myotonic dystrophy type 1. Bmj Case Reports. 12. PMID 30852496 DOI: 10.1136/bcr-2018-227233  0.064
1975 Sinclair DA. Crossing over between closely linked markers spanning the centromere of chromosome 3 in Drosophila melanogaster Genetical Research. 26: 173-185. PMID 817979 DOI: 10.1017/S0016672300015974  0.064
2015 Lubarsky DA, Guercio JR, Hanna JW, Abreu MT, Ma Q, Uribe C, Birnbach DJ, Sinclair DR, Candiotti KA. The impact of anesthesia providers on major morbidity following screening colonoscopies. Journal of Multidisciplinary Healthcare. 8: 255-70. PMID 26060404 DOI: 10.2147/Jmdh.S77408  0.063
2008 Sinclair D. Analytical aspects of thyroid antibodies estimation Autoimmunity. 41: 46-54. PMID 18176864 DOI: 10.1080/08916930701619466  0.061
2022 Valeri J, O'Donovan SM, Wang W, Sinclair D, Bollavarapu R, Gisabella B, Platt D, Stockmeier C, Pantazopoulos H. Altered expression of somatostatin signaling molecules and clock genes in the hippocampus of subjects with substance use disorder. Frontiers in Neuroscience. 16: 903941. PMID 36161151 DOI: 10.3389/fnins.2022.903941  0.06
2006 Sinclair D. Clinical and laboratory aspects of thyroid autoantibodies. Annals of Clinical Biochemistry. 43: 173-83. PMID 16704751 DOI: 10.1258/000456306776865043  0.059
2007 Sinclair DG. ICU management of pulmonary embolism Anaesthesia and Intensive Care Medicine. 8: 534-536. DOI: 10.1016/j.mpaic.2007.09.006  0.058
2006 Sinclair DA, Guarente L. Unlocking the Secrets of Longevity Genes Scientific American Sp. 16: 68-75. DOI: 10.1038/scientificamerican1206-68sp  0.058
2021 Guyatt G, Oxman AD, Kunz R, Brozek J, Alonso-Coello P, Rind D, Devereaux PJ, Montori VM, Freyschuss B, Vist G, Jaeschke R, Williams JW, Murad MH, Sinclair D, Falck-Ytter Y, et al. Corrigendum to GRADE guidelines 6. Rating the quality of evidence-imprecision. J Clin Epidemiol 2011;64:1283-1293. Journal of Clinical Epidemiology. 137: 265. PMID 34174652 DOI: 10.1016/j.jclinepi.2021.04.014  0.057
2011 Sinclair DG. Evidence over barriers: Important but not enough Healthcare Papers. 11: 57-60. PMID 21677520  0.056
1956 Sinclair DA. Absence of shock hazard with certain multigap spark circuits Nature. 177: 1175-1176. DOI: 10.1038/1771175a0  0.056
2016 Leibovici L, Paul M, Garner P, Sinclair DJ, Afshari A, Pace NL, Cullum N, Williams HC, Smyth A, Skoetz N, Del Mar C, Schilder AG, Yahav D, Tovey D. Addressing resistance to antibiotics in systematic reviews of antibiotic interventions. The Journal of Antimicrobial Chemotherapy. PMID 27169438 DOI: 10.1093/jac/dkw135  0.056
1948 SINCLAIR DC. Observations on sensory paralysis produced by compression of a human limb Journal of Neurophysiology. 11: 75-92. PMID 18905649  0.055
2004 Sinclair D, Resouly A, Spedding A. Stridor: unusual presentation of multiple myeloma. The Journal of Laryngology and Otology. 117: 829-31. PMID 14653930 DOI: 10.1258/002221503770716313  0.055
2020 Qi Y, Fang Y, Sinclair DR, Guo S, Alberich-Jorda M, Lu J, Tenen DG, Kharas MG, Pyne S. High-speed automatic characterization of rare events in flow cytometric data. Plos One. 15: e0228651. PMID 32045462 DOI: 10.1371/Journal.Pone.0228651  0.053
1991 Sinclair D. Review of solar neutrino projects Nuclear Physics B (Proceedings Supplements). 19: 100-109. DOI: 10.1016/0920-5632(91)90193-I  0.053
1994 Sinclair D. Myocardial infarction. Considerations for geriatric patients Canadian Family Physician. 40: 1172-1177. PMID 7912578  0.053
2005 McKeon DJ, White W, Sinclair D, Goldman JM. Pneumocystis carinii pneumonia infection in a patient with known chronic mucocutaneous candidiasis. Respirology (Carlton, Vic.). 10: 399-401. PMID 15955158 DOI: 10.1111/j.1440-1843.2005.00700.x  0.053
1993 Sinclair DG. The academic medical centre: An idea whose time has come Cmaj. 148: 1543-1545. PMID 8477377  0.051
2005 Sinclair D, Saas M, Cook LJ. In vitro allergy investigation: Does a multiple allergen testing system give useful information? Clinical Laboratory. 51: 395-401. PMID 16122150  0.05
1988 Sinclair D. Trouble in paradise: report on the status of animal experimentation in Finland International Journal of Psychology. Journal International De Psychologie. 23: 119-121. PMID 11650838  0.05
2014 Wu LE, Sinclair DA. SIRT2 controls the pentose phosphate switch. The Embo Journal. 33: 1287-8. PMID 24825350 DOI: 10.15252/embj.201488713  0.049
1950 Sinclair D. A bending method for measurement of the tensile strength and young's modulus of glass fibers Journal of Applied Physics. 21: 380-386. DOI: 10.1063/1.1699670  0.049
2023 Boekstein N, Barzilai N, Bertram A, Betts-LaCroix J, Fortney K, Helliwell SB, Hufford M, Mannick J, McLaughlin J, Mellon J, Morgen E, Regge N, Robinton DA, Sinclair DA, Young S, et al. Defining a longevity biotechnology company. Nature Biotechnology. PMID 37365260 DOI: 10.1038/s41587-023-01854-0  0.049
2021 Bakhaidar M, Wilcox JT, Sinclair DS, Diaz RJ. Ventriculoatrial Shunts: Review of Technical Aspects and Complications. World Neurosurgery. 158: 158-164. PMID 34775091 DOI: 10.1016/j.wneu.2021.11.025  0.049
2003 Sinclair D, Briston P, Rutland E. Intravascular haemolysis: a potential missed diagnosis. Clinical Laboratory. 48: 483-5. PMID 12389707  0.048
2014 Sinclair DR, Lubarsky DA, Vigoda MM, Birnbach DJ, Harris EA, Behrens V, Bazan RE, Williams SM, Arheart K, Candiotti KA. A matrix model for valuing anesthesia service with the resource-based relative value system. Journal of Multidisciplinary Healthcare. 7: 449-58. PMID 25336964 DOI: 10.2147/Jmdh.S68671  0.047
2009 Metcalfe S, Woodward A, Macmillan A, Baker M, Howden-Chapman P, Lindsay G, Hales S, Sinclair D, Jaine R, Springford L, Holmes A, Laking G, Jones R, Carr H, Edwards R, et al. Why New Zealand must rapidly halve its greenhouse gas emissions. The New Zealand Medical Journal. 122: 72-95. PMID 19859094  0.047
1982 Sinclair D. Particle size sensitivity of condensation nucleus counters Atmospheric Environment (1967). 16: 955-958. DOI: 10.1016/0004-6981(82)90181-0  0.047
2004 Sinclair DB. Jewish law in the state of Israel The Jewish Law Annual. 15: 229-241. DOI: 10.4324/9780203462133  0.046
1962 Sinclair DB. The Measuring Devices of Electronics Proceedings of the Ire. 50: 1164-1170. DOI: 10.1109/JRPROC.1962.288024  0.046
2006 Jude H, Sinclair DJ, Das N, Sherburn MS, Stang PJ. Self-assembly of supramolecular platinum complexes with bis-4-pyridyl cavitands Journal of Organic Chemistry. 71: 4155-4163. PMID 16709055 DOI: 10.1021/Jo060133O  0.046
1962 Sinclair DA. The machine translator and the translating profession Babel. 8: 76-78. DOI: 10.1075/babel.8.2.07sin  0.045
1940 Sinclair DB. The Twin-T A New Type of Null Instrument for Measuring Impedance at Frequencies up to 30 Megacycles Proceedings of the Ire. 28: 310-318. DOI: 10.1109/JRPROC.1940.229347  0.045
2002 Wood JG, Sinclair DA. TPE or not TPE? It's no longer a question. Trends in Pharmacological Sciences. 23: 1-4. PMID 11804639 DOI: 10.1016/S0165-6147(00)01891-5  0.044
2006 Booker JE, Boto A, Churchill GH, Green CP, Ling M, Meek G, Prabhakaran J, Sinclair D, Blake AJ, Pattenden G. Approaches to the quaternary stereocentre and to the heterocyclic core in diazonamide A using the Heck reaction and related coupling reactions. Organic & Biomolecular Chemistry. 4: 4193-205. PMID 17312976 DOI: 10.1039/B609604B  0.044
2010 Sinclair D, Preziosi MP, Jacob John T, Greenwood B. The epidemiology of meningococcal disease in India. Tropical Medicine & International Health : Tm & Ih. 15: 1421-35. PMID 21054695 DOI: 10.1111/j.1365-3156.2010.02660.x  0.044
1995 Sinclair D. HIV in the accident and emergency department Accident and Emergency Nursing. 3: 83-88. PMID 7773720 DOI: 10.1016/0965-2302(95)90089-6  0.044
2004 Sinclair D, Pearce CB, Saas MS, Poller D. A comparative study of tissue transglutaminase antibodies and endomysium antibody immunofluorescence in routine clinical laboratory practice. Annals of Clinical Biochemistry. 40: 411-6. PMID 12880544 DOI: 10.1258/000456303766477075  0.043
1961 Sinclair DP. Pithomyces chartarum spores on pasture and their relation to facial eczema in sheep New Zealand Journal of Agricultural Research. 4: 492-503. DOI: 10.1080/00288233.1961.10431607  0.043
1992 Sinclair DB. The Interaction Between Law and Morality in Jewish Law in the Areas of Feticide and Killing a Terminally Ill Individual Criminal Justice Ethics. 11: 76-84. PMID 11656185 DOI: 10.1080/0731129X.1992.9991928  0.043
1953 Sinclair DC. BASIC SCIENCE SOME OBSERVATIONS IN THE UNITED STATES The Lancet. 262: 463-467. PMID 13137542  0.042
2012 Al-Jehani H, Ajlan A, Sinclair D. Fahr's Disease Presenting with Aneurysmal Subarachnoid Hemorrhage. Journal of Clinical Imaging Science. 2: 27. PMID 22754741 DOI: 10.4103/2156-7514.96542  0.042
2021 Jones RA, Mortimer JW, Thompson CSG, Clark-Stewart S, Hogg G, Keni S, McCulloch V, Alashkham A, Dhumale S, Maclean SJ, Vella M, Findlater GS, Sinclair DW, Yalamarthi S, Gillingwater TH. Improving surgical training: Establishing a surgical anatomy programme in Scotland. International Journal of Surgery (London, England). 96: 106172. PMID 34763111 DOI: 10.1016/j.ijsu.2021.106172  0.042
2009 Nguyen TV, Sinclair DJ, Willis AC, Sherburn MS. Guest binding drives reversible atropisomerism in cavitand hosts. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 5892-5. PMID 19437468 DOI: 10.1002/chem.200900695  0.041
1938 Sinclair DB. Parallel-resonance methods for precise measurements of high impedances at radio frequencies and a comparison with the ordinary series-resonance methods Proceedings of the Institute of Radio Engineers. 26: 1466-1497. DOI: 10.1109/JRPROC.1938.228188  0.041
2005 Sinclair D. Sports education - A priority for Caribbean sports tourism International Journal of Contemporary Hospitality Management. 17: 536-548. DOI: 10.1108/09596110510612176  0.041
2003 Sinclair DR, Chung F, Smiley A. General anesthesia does not impair simulator driving skills in volunteers in the immediate recovery period - a pilot study. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 50: 238-45. PMID 12620945 DOI: 10.1007/BF03017791  0.041
2020 Chu KH, Shensa A, Colditz JB, Sidani JE, Hoffman BL, Sinclair D, Krauland MG, Primack BA. Integrating Social Dynamics Into Modeling Cigarette and E-Cigarette Use. Health Education & Behavior : the Official Publication of the Society For Public Health Education. 1090198119876242. PMID 32090652 DOI: 10.1177/1090198119876242  0.04
1973 Sinclair DA, Eales JG. Iodothyronine-glucuronide conjugates in the bile of brook trout, Salvelinus fontinalis (mitchill) and other freshwater teleosts. General and Comparative Endocrinology. 19: 552-98. PMID 4649171 DOI: 10.1016/0016-6480(72)90255-9  0.04
1964 Sinclair DA. Removing the shock hazard from spark-triggered arc electrodes Journal of Scientific Instruments. 41: 618-621. DOI: 10.1088/0950-7671/41/10/309  0.04
1986 Sinclair DF. DAMPING SYSTEMS TO LIMIT THE MOTION OF TALL BUILDINGS . 58-65.  0.04
2014 Radeva-Petrova D, Kayentao K, ter Kuile FO, Sinclair D, Garner P. Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no treatment. The Cochrane Database of Systematic Reviews. 10: CD000169. PMID 25300703 DOI: 10.1002/14651858.CD000169.pub3  0.04
2020 Gomez NAG, Warren N, Labko Y, Sinclair DR. Intrathecal Opioid Dosing During Spinal Anesthesia for Cesarean Section: An Integrative Review. Journal of Doctoral Nursing Practice. 13: 108-119. PMID 32817499 DOI: 10.1891/JDNP-D-19-00025  0.04
2020 Qaisar S, Brodsky LD, Barth RF, Leier C, Buja LM, Yildiz V, Mo X, Allenby P, Moore S, Ivanov I, Chen W, Thomas D, Rivera AC, Gamble D, Hartage R, ... ... Sinclair D, et al. An unexpected paradox: wall shear stress in the aorta is less in patients with severe atherosclerosis regardless of obesity. Cardiovascular Pathology : the Official Journal of the Society For Cardiovascular Pathology. 107313. PMID 33242600 DOI: 10.1016/j.carpath.2020.107313  0.039
1940 Sinclair DB. A Radio-Frequency Bridge for Impedance Measurements from 400 Kilocycles to 60 Megacycles Proceedings of the Ire. 28: 497-503. DOI: 10.1109/JRPROC.1940.228955  0.038
2007 Sinclair D, Wainwright L. How lab staff and the estimation of free light chains can combine to aid the diagnosis of light chain disease Clinical Laboratory. 53: 267-271. PMID 17605400  0.038
2017 Glass LJ, Sinclair D, Boerrigter D, Naude K, Fung SJ, Brown D, Catts VS, Tooney P, O'Donnell M, Lenroot R, Galletly C, Liu D, Weickert TW, Shannon Weickert C. Brain antibodies in the cortex and blood of people with schizophrenia and controls. Translational Psychiatry. 7: e1192. PMID 28786974 DOI: 10.1038/Tp.2017.134  0.038
2003 Sinclair D. Outsourcing the supply chain: principles to minimise costs. Medical Device Technology. 14: 18-20. PMID 14981888  0.038
1983 Sinclair D. INTRINSIC CALIBRATION OF THE POLLACK COUNTER - A REVISION Aerosol Science and Technology. 2: 235.  0.037
2003 Sinclair D, Cranfield T, Ganczakowski M. Paraprotein and beta2-microglobulin analyses in multiple myeloma--do we need to monitor both? Clinical Laboratory. 49: 129-34. PMID 12705694  0.037
1982 Sinclair DK. Monte Carlo calculations for an O(3) Z2 lattice spin model in 2 dimensions Nuclear Physics, Section B. 205: 173-187. DOI: 10.1016/0550-3213(82)90383-2  0.037
1974 Sinclair D. Heavy ion one- and two-photon transfer reactions Physics Letters B. 53: 54-56. DOI: 10.1016/0370-2693(74)90342-6  0.037
2020 Alamre A, Badhrees I, Death B, Licciardi C, Sinclair D. Isotopic Dependence of Vapor Pressure in Xenon. Acs Omega. 5: 28977-28983. PMID 33225128 DOI: 10.1021/acsomega.0c02883  0.036
2003 Sinclair DB. Prednisone therapy in pediatric epilepsy Pediatric Neurology. 28: 194-198. PMID 12770672 DOI: 10.1016/S0887-8994(02)00513-1  0.036
2004 Sinclair D, Smith H, Woodhead P. Spurious hyperphosphataemia caused by an IgA paraprotein: a topic revisited. Annals of Clinical Biochemistry. 41: 119-24. PMID 15025801 DOI: 10.1258/000456304322879999  0.035
2018 Xiao Y, Rivaz H, Kasuya H, Yokosako S, Mindru C, Teitelbaum J, Sirhan D, Sinclair D, Angle M, Lo BWY. Intra-operative Video Characterization of Carotid Artery Pulsation Patterns in Case Series with Post-endarterectomy Hypertension and Hyperperfusion Syndrome. Translational Stroke Research. PMID 29322480 DOI: 10.1007/S12975-017-0605-8  0.033
1972 Sinclair DK. Fourth-order contribution to Z3-1 in scalar electrodynamics Physical Review D. 6: 1181-1184. DOI: 10.1103/PhysRevD.6.1181  0.033
2007 Sinclair D, Saas M, Williams D, Hart M, Goswami R. Can an ELISA replace immunofluorescence for the detection of anti-nuclear antibodies?--The routine use of anti-nuclear antibody screening ELISAs. Clinical Laboratory. 53: 183-91. PMID 17447656  0.032
1960 Sinclair D, Beale H, Sharkey E. Sources of variation in the nickel airstream-stabilized arc Spectrochimica Acta. 16: 709-714. DOI: 10.1016/0371-1951(60)80122-1  0.032
2014 Sinclair D. Turning back time Chemistry and Industry (London). 78: 32-35. DOI: 10.1002/cind.7810-10.x  0.031
2011 Sinclair DR. Using the production possibility frontier to analyze operating room efficiency. Journal of Clinical Anesthesia. 23: 517-8. PMID 21782405 DOI: 10.1016/j.jclinane.2010.08.023  0.031
2008 Sinclair DK. Equilibrium thermodynamics of lattice QCD The Origin of Mass and Strong Coupling Gauge Theories - Proceedings of the 2006 International Workshop, Scgt 2006. 184-198.  0.031
1967 Sinclair D. A new photometer for aerosol particle size analysis Journal of the Air Pollution Control Association. 17: 105-108. DOI: 10.1080/00022470.1967.10468948  0.03
1970 Sinclair D. William Kirby and the Production of The U.E. Papers of the Bibliographical Society of Canada. 9. DOI: 10.33137/pbsc.v9i1.16816  0.03
2000 Sinclair D. Rethinking medicare: it's time to do it! Healthcarepapers. 1: 9-20. PMID 2003086808  0.03
2018 Westerman K, Reaver A, Roy C, Ploch M, Sharoni E, Nogal B, Sinclair DA, Katz DL, Blumberg JB, Blander G. Publisher Correction: Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects. Scientific Reports. 8: 16778. PMID 30405144 DOI: 10.1038/s41598-018-35249-y  0.03
2000 Sinclair D. Smooth region structure: folds, domes, bowls, ridges, valleys and slopes Proceedings of the Ieee Computer Society Conference On Computer Vision and Pattern Recognition. 1: 389-394.  0.029
2010 Sinclair DG. Opinions: When healthcare is bad for your health Healthcare Quarterly (Toronto, Ont.). 13: 8. PMID 20357536  0.029
2021 Welsh CE, Sinclair DR, Matthews FE. Static Socio-Ecological COVID-19 Vulnerability Index and Vaccine Hesitancy Index for England. The Lancet Regional Health. Europe. 14: 100296. PMID 34981041 DOI: 10.1016/j.lanepe.2021.100296  0.028
2002 Pearce AB, Sinclair D, Duncan HD, Saas M, Poller DN. Use of the anti-endomysial antibody test to diagnose coeliac disease in clinical practice. Clinical Laboratory. 48: 319-25. PMID 12071583  0.027
2005 Briston P, Sinclair D. Antibodies to thyroid peroxidase (TPOAb) in serum from patients with slightly raised thyrotropin (TSH) levels. Clinical Laboratory. 50: 383-6. PMID 15330504  0.027
1970 Sinclair DC. Optical loss and thermal distortion in gas-laser brewster windows Applied Optics. 9: 797-801. DOI: 10.1364/AO.9.000797  0.027
1996 Sinclair DK. Light hadron spectroscopy Nuclear Physics B - Proceedings Supplements. 47: 112-127. DOI: 10.1016/0920-5632(96)00037-0  0.026
1955 Sinclair DC. Cutaneous sensation and the doctrine of specific energy Brain. 78: 584-614. PMID 13293271 DOI: 10.1093/brain/78.4.584  0.026
1994 Sinclair D, McCormack J, Bray R. Evaluation of immunomagnetically separated cells for flow cytometric crossmatching Human Immunology. 40: 167. DOI: 10.1016/0198-8859(94)91991-7  0.026
1999 Sinclair DS. Work disability and soft tissue rheumatism Journal of Rheumatology. 26: 1414. PMID 10381068  0.026
2005 Chung F, Kayumov L, Sinclair DR, Edward R, Moller HJ, Shapiro CM. What is the driving performance of ambulatory surgical patients after general anesthesia? Anesthesiology. 103: 951-6. PMID 16249668 DOI: 10.1097/00000542-200511000-00008  0.026
2004 Sinclair DG. Leaders up front, please! Healthcare Quarterly (Toronto, Ont.). 7. PMID 15088326  0.026
2002 Sinclair D. Academic health sciences centres: not enough has changed Hospital Quarterly. 5: 8. PMID 12090238  0.026
1988 Sinclair DK. Hybrid simulations with dynamical quarks: Spectra, screening and thermodynamics Nuclear Physics B (Proceedings Supplements). 4: 225-228. DOI: 10.1016/0920-5632(88)90107-7  0.026
1980 Sinclair DB. The legal basis for the prohibition on abortion in Jewish law Israel Law Review. 15: 109-130. PMID 11664084  0.026
2011 Sinclair D, Donegan S, Lalloo DG. Artesunate versus quinine for treating severe malaria. The Cochrane Database of Systematic Reviews. CD005967. PMID 21412892 DOI: 10.1002/14651858.CD005967.pub3  0.025
2019 Wu LE, Sinclair DA. The elusive NMN transporter is found. Nature Metabolism. 1: 8-9. PMID 32694812 DOI: 10.1038/s42255-018-0015-6  0.025
2004 Sinclair D. Pneumonia in the ICU Anaesthesia and Intensive Care Medicine. 5: 383-385. DOI: 10.1383/anes.5.11.383.53405  0.025
1968 Sinclair D. Protesting mathematicians Science. 162: 1076.  0.025
1980 Sinclair DC. Optical design using small dedicated computers Proceedings of Spie - the International Society For Optical Engineering. 237: 33-41. DOI: 10.1117/12.959063  0.024
1967 Sinclair DM. Obesity as a public health problem Canadian Journal of Public Health. 58: 520-521. PMID 6077088  0.024
2011 Sinclair D, Gogtay N, Brand F, Olliaro P. Artemisinin-based combination therapy for treating uncomplicated Plasmodium vivax malaria. The Cochrane Database of Systematic Reviews. CD008492. PMID 21735431 DOI: 10.1002/14651858.CD008492.pub2  0.024
1997 Sinclair D. Devolution to whom? Healthcare Management Forum / Canadian College of Health Service Executives = Forum Gestion Des Soins De Santé / CollèGe Canadien Des Directeurs De Services De Santé. 10. PMID 10173499  0.023
1991 Sinclair DW. A comparison of transition Reynolds number measured in a wind tunnel and in flight .  0.023
1976 Sinclair D. Penetration of hepa filters by submicron aerosols Journal of Aerosol Science. 7: 175-179. DOI: 10.1016/0021-8502(76)90073-2  0.023
2016 Drouin S, Kochanowska A, Kersten-Oertel M, Gerard IJ, Zelmann R, De Nigris D, Bériault S, Arbel T, Sirhan D, Sadikot AF, Hall JA, Sinclair DS, Petrecca K, DelMaestro RF, Collins DL. IBIS: an OR ready open-source platform for image-guided neurosurgery. International Journal of Computer Assisted Radiology and Surgery. PMID 27581336 DOI: 10.1007/S11548-016-1478-0  0.023
2016 Al-Jehani H, Petrecca K, Martel P, Sinclair D, Sirhan D. Decompressive Craniectomy for Ischemic Stroke: Effect of Hemorrhagic Transformation on Outcome. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association. PMID 27468660 DOI: 10.1016/j.jstrokecerebrovasdis.2015.12.039  0.023
2015 Kersten-Oertel M, Gerard I, Drouin S, Mok K, Sirhan D, Sinclair DS, Collins DL. Augmented reality in neurovascular surgery: feasibility and first uses in the operating room. International Journal of Computer Assisted Radiology and Surgery. PMID 25712917 DOI: 10.1007/s11548-015-1163-8  0.023
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