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Paul B. Savage - Publications

Affiliations: 
Chemistry Brigham Young University, Provo, UT, United States 
Area:
Organic Chemistry
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Year Citation  Score
2020 Hacioglu M, Oyardi O, Bozkurt-Guzel C, Savage PB. Antibiofilm activities of ceragenins and antimicrobial peptides against fungal-bacterial mono and multispecies biofilms. The Journal of Antibiotics. PMID 32203127 DOI: 10.1038/S41429-020-0299-0  0.349
2020 Bozkurt-Guzel C, Inci G, Oyardi O, Savage PB. Synergistic Activity of Ceragenins Against Carbapenem-Resistant Acinetobacter baumannii Strains in Both Checkerboard and Dynamic Time-Kill Assays. Current Microbiology. PMID 32189050 DOI: 10.1007/S00284-020-01949-W  0.348
2020 Dao A, Mills R, Kamble S, Savage PB, Little DG, Schindeler A. The application of ceragenins (CSAs) to orthopedic surgery and medicine. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 31994754 DOI: 10.1002/Jor.24615  0.333
2020 Wnorowska U, Fiedoruk K, Piktel E, Prasad SV, Sulik M, Janion M, Daniluk T, Savage PB, Bucki R. Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications. Journal of Nanobiotechnology. 18: 3. PMID 31898542 DOI: 10.1186/S12951-019-0566-Z  0.31
2019 Hacioglu M, Haciosmanoglu E, Birteksoz-Tan AS, Bozkurt-Guzel C, Savage PB. Effects of ceragenins and conventional antimicrobials on Candida albicans and Staphylococcus aureus mono and multispecies biofilms. Diagnostic Microbiology and Infectious Disease. 114863. PMID 31471074 DOI: 10.1016/J.Diagmicrobio.2019.06.014  0.354
2019 Ozbek-Celik B, Damar-Celik D, Mataraci-Kara E, Bozkurt-Guzel C, Savage PB. Comparative In Vitro Activities of First and Second-Generation Ceragenins Alone and in Combination with Antibiotics Against Multidrug-Resistant Strains. Antibiotics (Basel, Switzerland). 8. PMID 31461867 DOI: 10.3390/Antibiotics8030130  0.319
2019 Wnorowska U, Piktel E, Durnaś B, Fiedoruk K, Savage PB, Bucki R. Use of ceragenins as a potential treatment for urinary tract infections. Bmc Infectious Diseases. 19: 369. PMID 31046689 DOI: 10.1186/S12879-019-3994-3  0.324
2019 Hashemi MM, Holden BS, Coburn J, Taylor MF, Weber S, Hilton B, Zaugg AL, McEwan C, Carson R, Andersen JL, Price JC, Deng S, Savage PB. Proteomic Analysis of Resistance of Gram-Negative Bacteria to Chlorhexidine and Impacts on Susceptibility to Colistin, Antimicrobial Peptides, and Ceragenins. Frontiers in Microbiology. 10: 210. PMID 30833936 DOI: 10.3389/Fmicb.2019.00210  0.314
2019 Birteksoz-Tan AS, Zeybek Z, Hacioglu M, Savage PB, Bozkurt-Guzel C. In vitro activities of antimicrobial peptides and ceragenins against Legionella pneumophila. The Journal of Antibiotics. PMID 30755738 DOI: 10.1038/S41429-019-0148-1  0.324
2018 Hashemi MM, Mmuoegbulam AO, Holden BS, Coburn J, Wilson J, Taylor MF, Reiley J, Baradaran D, Stenquist T, Deng S, Savage PB. Susceptibility of Multidrug-Resistant Bacteria, Isolated from Water and Plants in Nigeria, to Ceragenins. International Journal of Environmental Research and Public Health. 15. PMID 30563216 DOI: 10.3390/Ijerph15122758  0.344
2018 Schmid H, Schneidawind C, Jahnke S, Kettemann F, Secker KA, Duerr-Stoerzer S, Keppeler H, Kanz L, Savage PB, Schneidawind D. Culture-Expanded Human Invariant Natural Killer T Cells Suppress T-Cell Alloreactivity and Eradicate Leukemia. Frontiers in Immunology. 9: 1817. PMID 30127790 DOI: 10.3389/Fimmu.2018.01817  0.339
2018 Piktel E, Prokop I, Wnorowska U, Król G, Cieśluk M, Niemirowicz K, Savage PB, Bucki R. Ceragenin CSA-13 as free molecules and attached to magnetic nanoparticle surfaces induce caspase-dependent apoptosis in human breast cancer cells via disruption of cell oxidative balance. Oncotarget. 9: 21904-21920. PMID 29774111 DOI: 10.18632/Oncotarget.25105  0.313
2018 Mills R, Cheng TL, Mikulec K, Peacock L, Isaacs D, Genberg C, Savage PB, Little DG, Schindeler A. CSA-90 Promotes Bone Formation and Mitigates Methicillin-resistant Staphylococcus aureus Infection in a Rat Open Fracture Model. Clinical Orthopaedics and Related Research. PMID 29698291 DOI: 10.1097/01.Blo.0000533624.79802.E1  0.307
2018 Bozkurt-Guzel C, Hacioglu M, Savage PB. Investigation of the in vitro antifungal and antibiofilm activities of ceragenins CSA-8, CSA-13, CSA-44, CSA-131, and CSA-138 against Candida species. Diagnostic Microbiology and Infectious Disease. PMID 29680320 DOI: 10.1016/J.Diagmicrobio.2018.03.014  0.307
2018 Hashemi MM, Holden BS, Taylor MF, Wilson J, Coburn J, Hilton B, Nance T, Gubler S, Genberg C, Deng S, Savage PB. Antibacterial and Antifungal Activities of Poloxamer Micelles Containing Ceragenin CSA-131 on Ciliated Tissues. Molecules (Basel, Switzerland). 23. PMID 29518893 DOI: 10.3390/Molecules23030596  0.327
2018 Bucki R, Durnaś B, Wątek M, Piktel E, Cruz K, Wolak P, Savage PB, Janmey PA. Targeting polyelectrolyte networks in purulent body fluids to modulate bactericidal properties of some antibiotics. Infection and Drug Resistance. 11: 77-86. PMID 29391814 DOI: 10.2147/Idr.S145337  0.318
2018 Iweala OI, Savage PB, Commins SP. A Role for CD1d-restricted Invariant Natural Killer T Cells and Glycolipids in Alpha-Gal Allergy Journal of Allergy and Clinical Immunology. 141: AB288. DOI: 10.1016/J.Jaci.2017.12.918  0.318
2017 Durnaś B, Piktel E, Wątek M, Wollny T, Góźdź S, Smok-Kalwat J, Niemirowicz K, Savage PB, Bucki R. Anaerobic bacteria growth in the presence of cathelicidin LL-37 and selected ceragenins delivered as magnetic nanoparticles cargo. Bmc Microbiology. 17: 167. PMID 28747178 DOI: 10.1186/S12866-017-1075-6  0.328
2017 Pogoda K, Piktel E, Deptuła P, Savage PB, Lekka M, Bucki R. Stiffening of bacteria cells as a first manifestation of bactericidal attack. Micron (Oxford, England : 1993). 101: 95-102. PMID 28683405 DOI: 10.1016/J.Micron.2017.06.011  0.385
2017 Olekson MA, You T, Savage PB, Leung KP. Antimicrobial ceragenins inhibit biofilms and affect mammalian cell viability and migration in vitro. Febs Open Bio. 7: 953-967. PMID 28680809 DOI: 10.1002/2211-5463.12235  0.336
2017 Niemirowicz K, Durnaś B, Tokajuk G, Piktel E, Michalak G, Gu X, Kułakowska A, Savage PB, Bucki R. Formulation and candidacidal activity of magnetic nanoparticles coated with cathelicidin LL-37 and ceragenin CSA-13. Scientific Reports. 7: 4610. PMID 28676673 DOI: 10.1038/S41598-017-04653-1  0.335
2017 Hashemi MM, Rovig J, Weber S, Hilton B, Forouzan MM, Savage PB. Susceptibility of colistin-resistant, Gram-negative bacteria to antimicrobial peptides and ceragenins. Antimicrobial Agents and Chemotherapy. PMID 28584137 DOI: 10.1128/Aac.00292-17  0.312
2017 Deng S, Kain L, Pereira CS, Mata S, Macedo MF, Bendelac A, Teyton L, Savage PB. Psychosine variants as antigens for natural killer T cells. Chemical Science. 8: 2204-2208. PMID 28507675 DOI: 10.1039/C6Sc04218J  0.343
2017 Piktel E, Pogoda K, Roman M, Niemirowicz K, Tokajuk G, Wróblewska M, Szynaka B, Kwiatek WM, Savage PB, Bucki R. Sporicidal activity of ceragenin CSA-13 against Bacillus subtilis. Scientific Reports. 7: 44452. PMID 28294162 DOI: 10.1038/Srep44452  0.334
2017 Polonskaya Z, Deng S, Sarkar A, Kain L, Comellas-Aragones M, McKay CS, Kaczanowska K, Holt M, McBride R, Palomo V, Self KM, Taylor S, Irimia A, Mehta SR, Dan JM, ... ... Savage PB, et al. T cells control the generation of nanomolar-affinity anti-glycan antibodies. The Journal of Clinical Investigation. PMID 28287405 DOI: 10.1172/Jci91192  0.32
2016 Li B, Siuta M, Bright V, Koktysh D, Matlock BK, Dumas ME, Zhu M, Holt A, Stec D, Deng S, Savage PB, Joyce S, Pham W. Improved proliferation of antigen-specific cytolytic T lymphocytes using a multimodal nanovaccine. International Journal of Nanomedicine. 11: 6103-6121. PMID 27895483 DOI: 10.2147/Ijn.S112432  0.305
2016 Niemirowicz K, Piktel E, Wilczewska AZ, Markiewicz KH, Durnaś B, Wątek M, Puszkarz I, Wróblewska M, Niklińska W, Savage PB, Bucki R. Core-shell magnetic nanoparticles display synergistic antibacterial effects against Pseudomonas aeruginosa and Staphylococcus aureus when combined with cathelicidin LL-37 or selected ceragenins. International Journal of Nanomedicine. 11: 5443-5455. PMID 27799768 DOI: 10.2147/Ijn.S113706  0.354
2016 Cruz Tleugabulova M, Escalante NK, Deng S, Fieve S, Ereño-Orbea J, Savage PB, Julien JP, Mallevaey T. Discrete TCR Binding Kinetics Control Invariant NKT Cell Selection and Central Priming. Journal of Immunology (Baltimore, Md. : 1950). PMID 27798168 DOI: 10.4049/Jimmunol.1601382  0.334
2016 Durnaś B, Wnorowska U, Pogoda K, Deptuła P, Wątek M, Piktel E, Głuszek S, Gu X, Savage PB, Niemirowicz K, Bucki R. Candidacidal Activity of Selected Ceragenins and Human Cathelicidin LL-37 in Experimental Settings Mimicking Infection Sites. Plos One. 11: e0157242. PMID 27315208 DOI: 10.1371/Journal.Pone.0157242  0.375
2015 Bucki R, Niemirowicz K, Wnorowska U, Byfield FJ, Piktel E, Wątek M, Janmey PA, Savage PB. Bactericidal Activity of Ceragenin CSA-13 in Cell Culture and in an Animal Model of Peritoneal Infection. Antimicrobial Agents and Chemotherapy. 59: 6274-82. PMID 26248361 DOI: 10.1128/Aac.00653-15  0.367
2015 Kain L, Costanzo A, Webb B, Holt M, Bendelac A, Savage PB, Teyton L. Endogenous ligands of natural killer T cells are alpha-linked glycosylceramides. Molecular Immunology. PMID 26141240 DOI: 10.1016/J.Molimm.2015.06.009  0.347
2015 Niemirowicz K, Prokop I, Wilczewska AZ, Wnorowska U, Piktel E, Wątek M, Savage PB, Bucki R. Magnetic nanoparticles enhance the anticancer activity of cathelicidin LL-37 peptide against colon cancer cells. International Journal of Nanomedicine. 10: 3843-53. PMID 26082634 DOI: 10.2147/Ijn.S76104  0.325
2015 Niemirowicz K, Surel U, Wilczewska AZ, Mystkowska J, Piktel E, Gu X, Namiot Z, Ku?akowska A, Savage PB, Bucki R. Bactericidal activity and biocompatibility of ceragenin-coated magnetic nanoparticles. Journal of Nanobiotechnology. 13: 32. PMID 25929281 DOI: 10.1186/S12951-015-0093-5  0.333
2015 Wnorowska U, Niemirowicz K, Myint M, Diamond SL, Wróblewska M, Savage PB, Janmey PA, Bucki R. Bactericidal activities of cathelicidin LL-37 and select cationic lipids against the hypervirulent Pseudomonas aeruginosa strain LESB58. Antimicrobial Agents and Chemotherapy. 59: 3808-15. PMID 25870055 DOI: 10.1128/Aac.00421-15  0.325
2014 Bozkurt-Guzel C, Savage PB, Akcali A, Ozbek-Celik B. Potential synergy activity of the novel ceragenin, CSA-13, against carbapenem-resistant Acinetobacter baumannii strains isolated from bacteremia patients. Biomed Research International. 2014: 710273. PMID 24804236 DOI: 10.1155/2014/710273  0.324
2013 Anderson BL, Teyton L, Bendelac A, Savage PB. Stimulation of natural killer T cells by glycolipids. Molecules (Basel, Switzerland). 18: 15662-88. PMID 24352021 DOI: 10.3390/Molecules181215662  0.37
2013 Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, Savage PB, Jabri B, Bendelac A, Adams EJ. Crystal structure of Vδ1 T cell receptor in complex with CD1d-sulfatide shows MHC-like recognition of a self-lipid by human γδ T cells. Immunity. 39: 1032-42. PMID 24239091 DOI: 10.1016/J.Immuni.2013.11.001  0.339
2013 Chaudhary V, Albacker LA, Deng S, Chuang YT, Li Y, Umetsu DT, Savage PB. Synthesis of fungal glycolipid asperamide B and investigation of its ability to stimulate natural killer T cells. Organic Letters. 15: 5242-5. PMID 24111801 DOI: 10.1021/Ol4024375  0.571
2013 Bai L, Deng S, Reboulet R, Mathew R, Teyton L, Savage PB, Bendelac A. Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides. Proceedings of the National Academy of Sciences of the United States of America. 110: 16097-102. PMID 24043771 DOI: 10.1073/Pnas.1303218110  0.34
2013 Albacker LA, Chaudhary V, Chang YJ, Kim HY, Chuang YT, Pichavant M, DeKruyff RH, Savage PB, Umetsu DT. Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity. Nature Medicine. 19: 1297-304. PMID 23995283 DOI: 10.1038/Nm.3321  0.571
2013 Gu X, Jennings JD, Snarr J, Chaudhary V, Pollard JE, Savage PB. Optimization of ceragenins for prevention of bacterial colonization of hydrogel contact lenses. Investigative Ophthalmology & Visual Science. 54: 6217-23. PMID 23970466 DOI: 10.1167/Iovs.13-12664  0.548
2013 Nagant C, Pitts B, Stewart PS, Feng Y, Savage PB, Dehaye JP. Study of the effect of antimicrobial peptide mimic, CSA-13, on an established biofilm formed by Pseudomonas aeruginosa. Microbiologyopen. 2: 318-25. PMID 23436807 DOI: 10.1002/mbo3.77  0.459
2013 Leszczynska K, Namiot D, Byfield FJ, Cruz K, Zendzian-Piotrowska M, Fein DE, Savage PB, Diamond S, McCulloch CA, Janmey PA, Bucki R. Antibacterial activity of the human host defence peptide LL-37 and selected synthetic cationic lipids against bacteria associated with oral and upper respiratory tract infections. The Journal of Antimicrobial Chemotherapy. 68: 610-8. PMID 23134677 DOI: 10.1093/Jac/Dks434  0.344
2013 Luoma AM, Castro CD, Mayassi T, Bembinster LA, Bai L, Picard D, Anderson B, Scharf L, Kung JE, Sibener LV, Savage PB, Jabri B, Bendelac A, Adams EJ. Crystal Structure of V delta 1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human gamma delta T Cells. Immunity. 39: 1032-1042. DOI: 10.2210/Pdb4Mng/Pdb  0.316
2013 Zahoor R, Roohi S, Ahmad M, Iqbal Z, Amir N, Tariq S, Savage PB. Synthesis of 99mTc-cationic steroid antimicrobial-107 and in vitro evaluation Journal of Radioanalytical and Nuclear Chemistry. 295: 841-844. DOI: 10.1007/S10967-012-2016-3  0.319
2012 López-Sagaseta J, Kung JE, Savage PB, Gumperz J, Adams EJ. The molecular basis for recognition of CD1d/α-galactosylceramide by a human non-Vα24 T cell receptor. Plos Biology. 10: e1001412. PMID 23109910 DOI: 10.1371/Journal.Pbio.1001412  0.342
2012 Freigang S, Landais E, Zadorozhny V, Kain L, Yoshida K, Liu Y, Deng S, Palinski W, Savage PB, Bendelac A, Teyton L. Scavenger receptors target glycolipids for natural killer T cell activation. The Journal of Clinical Investigation. 122: 3943-54. PMID 23064364 DOI: 10.1172/Jci62267  0.336
2012 Williams DL, Haymond BS, Beck JP, Savage PB, Chaudhary V, Epperson RT, Kawaguchi B, Bloebaum RD. In vivo efficacy of a silicone‒cationic steroid antimicrobial coating to prevent implant-related infection. Biomaterials. 33: 8641-56. PMID 22940221 DOI: 10.1016/J.Biomaterials.2012.08.003  0.532
2012 Pollard JE, Snarr J, Chaudhary V, Jennings JD, Shaw H, Christiansen B, Wright J, Jia W, Bishop RE, Savage PB. In vitro evaluation of the potential for resistance development to ceragenin CSA-13. The Journal of Antimicrobial Chemotherapy. 67: 2665-72. PMID 22899801 DOI: 10.1093/Jac/Dks276  0.58
2012 Bai L, Picard D, Anderson B, Chaudhary V, Luoma A, Jabri B, Adams EJ, Savage PB, Bendelac A. The majority of CD1d-sulfatide-specific T cells in human blood use a semiinvariant Vδ1 TCR. European Journal of Immunology. 42: 2505-10. PMID 22829134 DOI: 10.1002/Eji.201242531  0.57
2012 Nagant C, Savage PB, Dehaye JP. Effect of pluronic acid F-127 on the toxicity towards eukaryotic cells of CSA-13, a cationic steroid analogue of antimicrobial peptides. Journal of Applied Microbiology. 112: 1173-83. PMID 22469097 DOI: 10.1111/J.1365-2672.2012.05297.X  0.337
2012 Lopez-Sagaseta J, Kung JE, Savage PB, Gumperz J, Adams EJ. The Molecular Basis for Recognition of CD1d/alpha-Galactosylceramide by a Human Non-Valpha24 T Cell Receptor Struct. Title Plos Biology. 10. DOI: 10.2210/Pdb4En3/Pdb  0.304
2011 Bozkurt-Guzel C, Savage PB, Gerceker AA. In vitro activities of the novel ceragenin CSA-13, alone or in combination with colistin, tobramycin, and ciprofloxacin, against Pseudomonas aeruginosa strains isolated from cystic fibrosis patients. Chemotherapy. 57: 505-10. PMID 22286090 DOI: 10.1159/000335588  0.325
2011 Byfield FJ, Kowalski M, Cruz K, Leszczy?ska K, Namiot A, Savage PB, Bucki R, Janmey PA. Cathelicidin LL-37 increases lung epithelial cell stiffness, decreases transepithelial permeability, and prevents epithelial invasion by Pseudomonas aeruginosa Journal of Immunology. 187: 6402-6409. PMID 22095714 DOI: 10.4049/Jimmunol.1102185  0.371
2011 Scanlon ST, Thomas SY, Ferreira CM, Bai L, Krausz T, Savage PB, Bendelac A. Airborne lipid antigens mobilize resident intravascular NKT cells to induce allergic airway inflammation. The Journal of Experimental Medicine. 208: 2113-24. PMID 21930768 DOI: 10.1084/Jem.20110522  0.312
2011 Deng S, Mattner J, Zang Z, Bai L, Teyton L, Bendelac A, Savage PB. Impact of sugar stereochemistry on natural killer T cell stimulation by bacterial glycolipids. Organic & Biomolecular Chemistry. 9: 7659-62. PMID 21927724 DOI: 10.1039/C1Ob06276J  0.362
2011 Nagant C, Feng Y, Lucas B, Braeckmans K, Savage P, Dehaye JP. Effect of a low concentration of a cationic steroid antibiotic (CSA-13) on the formation of a biofilm by Pseudomonas aeruginosa. Journal of Applied Microbiology. 111: 763-72. PMID 21699631 DOI: 10.1111/J.1365-2672.2011.05085.X  0.486
2011 Chang YJ, Kim HY, Albacker LA, Lee HH, Baumgarth N, Akira S, Savage PB, Endo S, Yamamura T, Maaskant J, Kitano N, Singh A, Bhatt A, Besra GS, van den Elzen P, et al. Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity. The Journal of Clinical Investigation. 121: 57-69. PMID 21157038 DOI: 10.1172/Jci44845  0.539
2011 Polat ZA, Savage PB, Genberg C. In vitro amoebicidal activity of a ceragenin, cationic steroid antibiotic-13, against Acanthamoeba castellanii and its cytotoxic potential. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. 27: 1-5. PMID 21142940 DOI: 10.1089/Jop.2010.0041  0.34
2011 Leszczy?ska K, Namiot A, Cruz K, Byfield FJ, Won E, Mendez G, Soko?owski W, Savage PB, Bucki R, Janmey PA. Potential of ceragenin CSA-13 and its mixture with pluronic F-127 as treatment of topical bacterial infections Journal of Applied Microbiology. 110: 229-238. PMID 20961363 DOI: 10.1111/J.1365-2672.2010.04874.X  0.329
2010 Lee HH, Meyer EH, Goya S, Pichavant M, Kim HY, Bu X, Umetsu SE, Jones JC, Savage PB, Iwakura Y, Casasnovas JM, Kaplan G, Freeman GJ, DeKruyff RH, Umetsu DT. Apoptotic cells activate NKT cells through T cell Ig-like mucin-like-1 resulting in airway hyperreactivity. Journal of Immunology (Baltimore, Md. : 1950). 185: 5225-35. PMID 20889552 DOI: 10.4049/Jimmunol.1001116  0.33
2010 Braun NA, Mendez-Fernandez YV, Covarrubias R, Porcelli SA, Savage PB, Yagita H, Van Kaer L, Major AS. Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 1758-65. PMID 20539017 DOI: 10.1161/Atvbaha.110.206045  0.347
2010 Freigang S, Zadorozhny V, McKinney MK, Krebs P, Herro R, Pawlak J, Kain L, Schrantz N, Masuda K, Liu Y, Savage PB, Bendelac A, Cravatt BF, Teyton L. Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice. The Journal of Clinical Investigation. 120: 1873-84. PMID 20484813 DOI: 10.1172/Jci40451  0.352
2010 Bucki R, Leszczynska K, Byfield FJ, Fein DE, Won E, Cruz K, Namiot A, Kulakowska A, Namiot Z, Savage PB, Diamond SL, Janmey PA. Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate. Antimicrobial Agents and Chemotherapy. 54: 2525-33. PMID 20308375 DOI: 10.1128/Aac.01682-09  0.371
2010 Semmling V, Lukacs-Kornek V, Thaiss CA, Quast T, Hochheiser K, Panzer U, Rossjohn J, Perlmutter P, Cao J, Godfrey DI, Savage PB, Knolle PA, Kolanus W, Förster I, Kurts C. Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nature Immunology. 11: 313-20. PMID 20190758 DOI: 10.1038/Ni.1848  0.314
2010 Lara D, Feng Y, Bader J, Savage PB, Maldonado RA. Anti-trypanosomatid activity of ceragenins. The Journal of Parasitology. 96: 638-42. PMID 19958044 DOI: 10.1645/Ge-2329.1  0.539
2009 Morshed SR, Takahashi T, Savage PB, Kambham N, Strober S. Beta-galactosylceramide alters invariant natural killer T cell function and is effective treatment for lupus. Clinical Immunology (Orlando, Fla.). 132: 321-33. PMID 19564135 DOI: 10.1016/J.Clim.2009.05.018  0.318
2009 Howell MD, Streib JE, Kim BE, Lesley LJ, Dunlap AP, Geng D, Feng Y, Savage PB, Leung DY. Ceragenins: a class of antiviral compounds to treat orthopox infections. The Journal of Investigative Dermatology. 129: 2668-75. PMID 19516269 DOI: 10.1038/Jid.2009.120  0.484
2009 Bai L, Sagiv Y, Liu Y, Freigang S, Yu KO, Teyton L, Porcelli SA, Savage PB, Bendelac A. Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer. Proceedings of the National Academy of Sciences of the United States of America. 106: 10254-9. PMID 19506241 DOI: 10.1073/Pnas.0901228106  0.316
2009 Kim HY, Pichavant M, Matangkasombut P, Koh YI, Savage PB, DeKruyff RH, Umetsu DT. The development of airway hyperreactivity in T-bet-deficient mice requires CD1d-restricted NKT cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 3252-61. PMID 19234223 DOI: 10.4049/Jimmunol.0803339  0.307
2009 Yin N, Long X, Goff RD, Zhou D, Cantu C, Mattner J, Mezard PS, Teyton L, Bendelac A, Savage PB. Alpha anomers of iGb3 and Gb3 stimulate cytokine production by natural killer T cells. Acs Chemical Biology. 4: 199-208. PMID 19175331 DOI: 10.1021/Cb800277N  0.754
2009 Farruggia G, Iotti S, Prodi L, Zaccheroni N, Montalti M, Savage PB, Andreani G, Trapani V, Wolf FI. A simple spectrofluorometric assay to measure total intracellular magnesium by a hydroxyquinoline derivative. Journal of Fluorescence. 19: 11-9. PMID 18528748 DOI: 10.1007/S10895-008-0374-6  0.335
2009 Pollard J, Wright J, Feng Y, Geng D, Genberg C, Savage PB. Activities of ceragenin CSA-13 against established biofilms in an in vitro model of catheter decolonization Anti-Infective Agents in Medicinal Chemistry. 8: 290-294. DOI: 10.2174/187152109789760225  0.503
2008 Epand RM, Epand RF, Savage PB. Ceragenins (cationic steroid compounds), a novel class of antimicrobial agents. Drug News & Perspectives. 21: 307-11. PMID 18836587 DOI: 10.1358/Dnp.2008.21.6.1246829  0.397
2008 Koh YI, Kim HY, Meyer EH, Pichavant M, Akbari O, Yasumi T, Savage PB, Dekruyff RH, Umetsu DT. Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 181: 4560-9. PMID 18802058 DOI: 10.4049/Jimmunol.181.7.4560  0.306
2008 Lai XZ, Feng Y, Pollard J, Chin JN, Rybak MJ, Bucki R, Epand RF, Epand RM, Savage PB. Ceragenins: cholic acid-based mimics of antimicrobial peptides. Accounts of Chemical Research. 41: 1233-40. PMID 18616297 DOI: 10.1021/Ar700270T  0.536
2008 Mattner J, Savage PB, Leung P, Oertelt SS, Wang V, Trivedi O, Scanlon ST, Pendem K, Teyton L, Hart J, Ridgway WM, Wicker LS, Gershwin ME, Bendelac A. Liver autoimmunity triggered by microbial activation of natural killer T cells. Cell Host & Microbe. 3: 304-15. PMID 18474357 DOI: 10.1016/J.Chom.2008.03.009  0.32
2008 Bucki R, Namiot DB, Namiot Z, Savage PB, Janmey PA. Salivary mucins inhibit antibacterial activity of the cathelicidin-derived LL-37 peptide but not the cationic steroid CSA-13. The Journal of Antimicrobial Chemotherapy. 62: 329-35. PMID 18456648 DOI: 10.1093/Jac/Dkn176  0.345
2008 Saha S, Savage PB, Bal M. Enhancement of the efficacy of erythromycin in multiple antibiotic-resistant gram-negative bacterial pathogens Journal of Applied Microbiology. 105: 822-828. PMID 18452533 DOI: 10.1111/J.1365-2672.2008.03820.X  0.354
2008 Matangkasombut P, Pichavant M, Yasumi T, Hendricks C, Savage PB, Dekruyff RH, Umetsu DT. Direct activation of natural killer T cells induces airway hyperreactivity in nonhuman primates. The Journal of Allergy and Clinical Immunology. 121: 1287-9. PMID 18355909 DOI: 10.1016/J.Jaci.2008.02.006  0.329
2008 Zajonc DM, Savage PB, Bendelac A, Wilson IA, Teyton L. Crystal Structures of Mouse CD1d-iGb3 Complex and its Cognate Vα14 T Cell Receptor Suggest a Model for Dual Recognition of Foreign and Self Glycolipids Journal of Molecular Biology. 377: 1104-1116. PMID 18295796 DOI: 10.1016/J.Jmb.2008.01.061  0.33
2008 Liu Y, Deng S, Bai L, Freigang S, Mattner J, Teyton L, Bendelac A, Savage PB. Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties. Bioorganic & Medicinal Chemistry Letters. 18: 3052-5. PMID 18206371 DOI: 10.1016/J.Bmcl.2007.12.067  0.33
2008 Chin JN, Jones RN, Sader HS, Savage PB, Rybak MJ. Potential synergy activity of the novel ceragenin, CSA-13, against clinical isolates of Pseudomonas aeruginosa, including multidrug-resistant P. aeruginosa. The Journal of Antimicrobial Chemotherapy. 61: 365-70. PMID 18079128 DOI: 10.1093/Jac/Dkm457  0.322
2008 Bhat S, Savage P, Li C, Taotafa U, Ding B, Guan Q, Milner SM. 139
Antimicrobial Activity of Synthetic Cationic Steroids on Burn Wound Pathogens Wound Repair and Regeneration. 13: A28-A48. DOI: 10.1111/J.1067-1927.2005.130216Aq.X  0.748
2007 Long X, Deng S, Mattner J, Zang Z, Zhou D, McNary N, Goff RD, Teyton L, Bendelac A, Savage PB. Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids. Nature Chemical Biology. 3: 559-64. PMID 17660835 DOI: 10.1038/Nchembio.2007.19  0.728
2007 Epand RF, Savage PB, Epand RM. Bacterial lipid composition and the antimicrobial efficacy of cationic steroid compounds (Ceragenins). Biochimica Et Biophysica Acta. 1768: 2500-9. PMID 17599802 DOI: 10.1016/J.Bbamem.2007.05.023  0.363
2007 Schrantz N, Sagiv Y, Liu Y, Savage PB, Bendelac A, Teyton L. The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells. The Journal of Experimental Medicine. 204: 841-52. PMID 17389239 DOI: 10.1084/Jem.20061562  0.32
2007 Chin JN, Rybak MJ, Cheung CM, Savage PB. Antimicrobial activities of ceragenins against clinical isolates of resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 51: 1268-73. PMID 17210765 DOI: 10.1128/Aac.01325-06  0.333
2007 Bendelac A, Savage PB, Teyton L. The biology of NKT cells. Annual Review of Immunology. 25: 297-336. PMID 17150027 DOI: 10.1146/Annurev.Immunol.25.022106.141711  0.361
2006 Savage PB, Teyton L, Bendelac A. Glycolipids for natural killer T cells. Chemical Society Reviews. 35: 771-9. PMID 16936925 DOI: 10.1039/B510638A  0.342
2006 Sagiv Y, Hudspeth K, Mattner J, Schrantz N, Stern RK, Zhou D, Savage PB, Teyton L, Bendelac A. Cutting edge: impaired glycosphingolipid trafficking and NKT cell development in mice lacking Niemann-Pick type C1 protein. Journal of Immunology (Baltimore, Md. : 1950). 177: 26-30. PMID 16785493 DOI: 10.4049/Jimmunol.177.1.26  0.311
2006 Campos-Martín Y, Colmenares M, Gozalbo-López B, López-Núñez M, Savage PB, Martínez-Naves E. Immature human dendritic cells infected with Leishmania infantum are resistant to NK-mediated cytolysis but are efficiently recognized by NKT cells. Journal of Immunology (Baltimore, Md. : 1950). 176: 6172-9. PMID 16670326 DOI: 10.4049/Jimmunol.176.10.6172  0.329
2006 Wei DG, Curran SA, Savage PB, Teyton L, Bendelac A. Mechanisms imposing the Vbeta bias of Valpha14 natural killer T cells and consequences for microbial glycolipid recognition. The Journal of Experimental Medicine. 203: 1197-207. PMID 16651387 DOI: 10.1084/Jem.20060418  0.356
2006 Liu Y, Goff RD, Zhou D, Mattner J, Sullivan BA, Khurana A, Cantu C, Ravkov EV, Ibegbu CC, Altman JD, Teyton L, Bendelac A, Savage PB. A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells. Journal of Immunological Methods. 312: 34-9. PMID 16647712 DOI: 10.1016/j.jim.2006.02.009  0.708
2006 Meyer EH, Goya S, Akbari O, Berry GJ, Savage PB, Kronenberg M, Nakayama T, DeKruyff RH, Umetsu DT. Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 2782-7. PMID 16478801 DOI: 10.1073/Pnas.0510282103  0.354
2006 Mattner J, DeBord KL, Ismail N, Goff RD, Cantu C, Zhou D, Saint-Mezard P, Wang V, Gao Y, Yin N, Hoebe K, Schneewind O, Walker D, Beutler B, Teyton L, ... Savage PB, et al. Correction: Corrigendum: Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections Nature. 439: 502-502. DOI: 10.1038/Nature04475  0.752
2005 Kichler A, Leborgne C, Savage PB, Danos O. Cationic steroid antibiotics demonstrate DNA delivery properties. Journal of Controlled Release : Official Journal of the Controlled Release Society. 107: 174-82. PMID 16126297 DOI: 10.1016/J.Jconrel.2005.08.002  0.363
2005 Lua YY, Yang L, Pew CA, Zhang F, Fillmore WJ, Bronson RT, Sathyapalan A, Savage PB, Whittaker JD, Davis RC, Linford MR. Polyelectrolytes as new matrices for secondary ion mass spectrometry. Journal of the American Society For Mass Spectrometry. 16: 1575-82. PMID 16085420 DOI: 10.1016/J.Jasms.2005.05.007  0.501
2005 Zajonc DM, Cantu C, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson IA, Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nature Immunology. 6: 810-8. PMID 16007091 DOI: 10.1038/Ni1224  0.355
2005 Mattner J, Debord KL, Ismail N, Goff RD, Cantu C, Zhou D, Saint-Mezard P, Wang V, Gao Y, Yin N, Hoebe K, Schneewind O, Walker D, Beutler B, Teyton L, ... Savage PB, et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature. 434: 525-9. PMID 15791258 DOI: 10.1038/Nature03408  0.771
2005 Bronson RT, Michaelis DJ, Lamb RD, Husseini GA, Farnsworth PB, Linford MR, Izatt RM, Bradshaw JS, Savage PB. Efficient immobilization of a cadmium chemosensor in a thin film: generation of a cadmium sensor prototype. Organic Letters. 7: 1105-8. PMID 15760150 DOI: 10.1021/Ol050027T  0.477
2004 Zhou D, Mattner J, Cantu C, Schrantz N, Yin N, Gao Y, Sagiv Y, Hudspeth K, Wu YP, Yamashita T, Teneberg S, Wang D, Proia RL, Levery SB, Savage PB, et al. Lysosomal glycosphingolipid recognition by NKT cells. Science (New York, N.Y.). 306: 1786-9. PMID 15539565 DOI: 10.1126/Science.1103440  0.565
2004 Ding B, Yin N, Liu Y, Cardenas-Garcia J, Evanson R, Orsak T, Fan M, Turin G, Savage PB. Origins of cell selectivity of cationic steroid antibiotics. Journal of the American Chemical Society. 126: 13642-8. PMID 15493921 DOI: 10.1021/Ja046909P  0.575
2004 Goff RD, Gao Y, Mattner J, Zhou D, Yin N, Cantu C, Teyton L, Bendelac A, Savage PB. Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells. Journal of the American Chemical Society. 126: 13602-3. PMID 15493902 DOI: 10.1021/Ja045385Q  0.753
2004 Ding B, Taotofa U, Orsak T, Chadwell M, Savage PB. Synthesis and characterization of peptide-cationic steroid antibiotic conjugates. Organic Letters. 6: 3433-6. PMID 15387516 DOI: 10.1021/Ol048845T  0.381
2003 Cantu C, Benlagha K, Savage PB, Bendelac A, Teyton L. The paradox of immune molecular recognition of alpha-galactosylceramide: low affinity, low specificity for CD1d, high affinity for alpha beta TCRs. Journal of Immunology (Baltimore, Md. : 1950). 170: 4673-82. PMID 12707346 DOI: 10.4049/Jimmunol.170.9.4673  0.337
2003 Yin N, Marshall RL, Matheson S, Savage PB. Synthesis of lipid A derivatives and their interactions with polymyxin B and polymyxin B nonapeptide. Journal of the American Chemical Society. 125: 2426-35. PMID 12603130 DOI: 10.1021/Ja0284456  0.515
2002 Savage PB, Li C, Taotafa U, Ding B, Guan Q. Antibacterial properties of cationic steroid antibiotics. Fems Microbiology Letters. 217: 1-7. PMID 12445638 DOI: 10.1111/J.1574-6968.2002.Tb11448.X  0.766
2002 Bendelac A, Teyton L, Savage PB. Lipid presentation by CD1: the short and the long lipid story. Nature Immunology. 3: 421-2. PMID 11976717 DOI: 10.1038/Ni0502-421  0.3
2002 Zhou XT, Forestier C, Goff RD, Li C, Teyton L, Bendelac A, Savage PB. Synthesis and NKT cell stimulating properties of fluorophore- and biotin-appended 6"-amino-6"-deoxy-galactosylceramides. Organic Letters. 4: 1267-70. PMID 11950339 DOI: 10.1021/Ol025565+  0.755
2002 Ding B, Guan Q, Walsh JP, Boswell JS, Winter TW, Winter ES, Boyd SS, Li C, Savage PB. Correlation of the antibacterial activities of cationic peptide antibiotics and cationic steroid antibiotics. Journal of Medicinal Chemistry. 45: 663-9. PMID 11806717 DOI: 10.1021/Jm0105070  0.557
2002 Chiu YH, Park SH, Benlagha K, Forestier C, Jayawardena-Wolf J, Savage PB, Teyton L, Bendelac A. Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d. Nature Immunology. 3: 55-60. PMID 11731798 DOI: 10.1038/Ni740  0.305
2002 Savage P. Cationic Steroid Antibiotics Current Medicinal Chemistry -Anti-Infective Agents. 1: 293-304. DOI: 10.2174/1568012023354776  0.332
2002 Savage PB. Design, synthesis and characterization of cationic peptide and steroid antibiotics European Journal of Organic Chemistry. 759-768. DOI: 10.1002/1099-0690(200203)2002:5<759::Aid-Ejoc759>3.0.Co;2-J  0.392
2001 Bronson RT, Bradshaw JS, Savage PB, Fuangswasdi S, Sang Chul Lee, Krakowiak KE, Izatt RM. Bis-8-hydroxyquinoline-armed diazatrithia-15-crown-5 and diazatrithia-16-crown-5 ligands: Possible fluorophoric metal ion sensors Journal of Organic Chemistry. 66: 4752-4758. PMID 11442399 DOI: 10.1021/Jo0017584  0.523
2001 Savage PB. Multidrug-resistant bacteria: Overcoming antibiotic permeability barriers of Gram-negative bacteria Annals of Medicine. 33: 167-171. PMID 11370769 DOI: 10.3109/07853890109002073  0.383
2001 Schmidt EJ, Boswell JS, Walsh JP, Schellenberg MM, Winter TW, Li C, Allman GW, Savage PB. Activities of cholic acid-derived antimicrobial agents against multidrug-resistant bacteria. The Journal of Antimicrobial Chemotherapy. 47: 671-4. PMID 11328782 DOI: 10.1093/Jac/47.5.671  0.538
2001 Song HC, Bradshaw JS, Chen YW, Xue GP, Chiara JA, Krakowiak KE, Savage PB, Xue ZL, Izatt RM. Syntheses of diazadithiacrown ethers containing two 8-hydroxyquinoline side arms Arkivoc. 2001: 25-35. DOI: 10.3998/Ark.5550190.0002.504  0.307
2001 Kawakami J, Bronson RT, Xue G, Bradshaw JS, Izatt RM, Savage PB. Characterization of bis-8-hydroxyquinoline-armed diazatrithia-16-crown-5 and diazadibenzo-18-crown-6 ligands as fluorescent chemosensors for zinc Journal of Supramolecular Chemistry. 1: 221-227. DOI: 10.1016/S1472-7862(02)00029-1  0.499
2000 Taotafa U, McMullin DB, Lee SC, Hansen LD, Savage PB. Anionic facial amphiphiles from cholic acid. Organic Letters. 2: 4117-20. PMID 11150178 DOI: 10.1021/Ol0064056  0.738
2000 Savage PB, Li C. Cholic acid derivatives: novel antimicrobials. Expert Opinion On Investigational Drugs. 9: 263-72. PMID 11060676 DOI: 10.1517/13543784.9.2.263  0.552
2000 Zhou XT, Rehman A, Li C, Savage PB. Preparation of a protected triamino analogue of cholic acid and sequential incorporation of amino acids in solution and on a solid support. Organic Letters. 2: 3015-8. PMID 10986096 DOI: 10.1021/Ol006336V  0.486
2000 Guan Q, Li C, Schmidt EJ, Boswell JS, Walsh JP, Allman GW, Savage PB. Preparation and characterization of cholic acid-derived antimicrobial agents with controlled stabilities. Organic Letters. 2: 2837-40. PMID 10964378 DOI: 10.1021/ol0062704  0.476
1999 Yang Z, Bradshaw JS, Zhang XX, Savage PB, Krakowiak KE, Dalley NK, Su N, Bronson RT, Izatt RM. New Tetraazacrown Ethers Containing Two Pyridine, Quinoline, 8-Hydroxyquinoline, or 8-Aminoquinoline Sidearms. The Journal of Organic Chemistry. 64: 3162-3170. PMID 11674416 DOI: 10.1021/Jo982292G  0.474
1999 Li C, Lewis MR, Gilbert AB, Noel MD, Scoville DH, Allman GW, Savage PB. Antimicrobial activities of amine- and guanidine-functionalized cholic acid derivatives. Antimicrobial Agents and Chemotherapy. 43: 1347-9. PMID 10348750 DOI: 10.1128/Aac.43.6.1347  0.548
1999 Li C, Budge LP, Driscoll CD, Willardson BM, Allman GW, Savage PB. Incremental conversion of outer-membrane permeabilizers into potent antibiotics for gram-negative bacteria Journal of the American Chemical Society. 121: 931-940. DOI: 10.1021/Ja982938M  0.542
1999 Li C, Atiq-ur-Rehman, Dalley NK, Savage PB. Short syntheses of triamine derivatives of cholic acid Tetrahedron Letters. 40: 1861-1864. DOI: 10.1016/S0040-4039(99)00076-3  0.462
1999 Atiq-ur-Rehman, Li C, Budge LP, Street SE, Savage PB. Preparation of amino acid-appended cholic acid derivatives as sensitizers of Gram-negative bacteria Tetrahedron Letters. 40: 1865-1868. DOI: 10.1016/S0040-4039(99)00075-1  0.489
1998 Li C, Peters AS, Meredith EL, Allman GW, Savage PB. Design and Synthesis of Potent Sensitizers of Gram-Negative Bacteria Based on a Cholic Acid Scaffolding Journal of the American Chemical Society. 120: 2961-2962. DOI: 10.1021/Ja973881R  0.503
1997 Bordunov AV, Bradshaw JS, Pastushok VN, Zhang XX, Kou X, Dalley NK, Yang Z, Savage PB, Izatt RM. Azacrown ethers containing oximic an Schiff base sidearms - Potential heteronuclear metal ion receptors Tetrahedron. 53: 17595-17606. DOI: 10.1016/S0040-4020(97)10229-0  0.301
1997 Holmgren SK, Savage PB, Desper JM, Schladetzky KD, Powell DR, Gellman SH. Steric control of oxidation selectivity in macrycyclic phosphine oxide-dithioethers Tetrahedron. 53: 12249-12262. DOI: 10.1016/S0040-4020(97)00557-7  0.432
1994 Savage PB, Holmgren SK, Gellman SH. Anion and ion pair complexation by a macrocyclic phosphine oxide disulfoxide Journal of the American Chemical Society. 116: 4069-4070. DOI: 10.1021/Ja00088A049  0.444
1993 Savage PB, Holmgren SK, Desper JM, Gellman SH. Macrocycles containing sulfur and phosphorus: Structure and complexation properties Pure and Applied Chemistry. 65: 461-466. DOI: 10.1351/Pac199365030461  0.455
1993 Savage PB, Gellman SH. Complexation of hexosammonium ions: evidence for contributions from OH.cntdot..cntdot..cntdot.OH hydrogen bonds in a hydroxylic medium Journal of the American Chemical Society. 115: 10448-10449. DOI: 10.1021/Ja00075A106  0.435
1993 Savage PB, Holmgren SK, Gellman SH. Optimization of a phosphine oxide disulfoxide array for multipoint hydrogen bonding to ammonium ions Journal of the American Chemical Society. 115: 7900-7901. DOI: 10.1021/Ja00070A055  0.423
1992 Savage PB, Desper JM, Gellman SH. Stereoselective oxidation of an eleven-membered heterocycle Tetrahedron Letters. 33: 2107-2110. DOI: 10.1016/0040-4039(92)88152-U  0.437
Low-probability matches (unlikely to be authored by this person)
2017 Hashemi MM, Rovig J, Bateman J, Holden BS, Modelzelewski T, Gueorguieva I, von Dyck M, Bracken R, Genberg C, Deng S, Savage PB. Preclinical testing of a broad-spectrum antimicrobial endotracheal tube coated with an innate immune synthetic mimic. The Journal of Antimicrobial Chemotherapy. PMID 29029265 DOI: 10.1093/Jac/Dkx347  0.3
2014 Kain L, Webb B, Anderson BL, Deng S, Holt M, Costanzo A, Constanzo A, Zhao M, Self K, Teyton A, Everett C, Kronenberg M, Zajonc DM, Bendelac A, Savage PB, et al. The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian α-linked glycosylceramides. Immunity. 41: 543-54. PMID 25367571 DOI: 10.1016/J.Immuni.2014.08.017  0.299
2002 Song HC, Bradshaw JS, Chen YW, Xue GP, Li WM, Krakowiak KE, Savage PB, Xu ZL, Izzat RM. Synthesis of new crown ethers containing appended pyridine, 10-hydroxybenzoquinoline, 8-hydroxyquinoline and 2-amino-1-hydroxybiphenyl sidearms Supramolecular Chemistry. 14: 263-269. DOI: 10.1080/10610270290026176  0.299
2007 Michel ML, Keller AC, Paget C, Fujio M, Trottein F, Savage PB, Wong CH, Schneider E, Dy M, Leite-de-Moraes MC. Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia. The Journal of Experimental Medicine. 204: 995-1001. PMID 17470641 DOI: 10.1084/Jem.20061551  0.298
1999 Su N, Bradshaw JS, Savage PB, Krakowiak KE, Izatt RM, De Wall SL, Gokel GW. Syntheses and aggregate study of bisphenol-containing diaza-18-crown-6 ligands Tetrahedron. 55: 9737-9742. DOI: 10.1016/S0040-4020(99)00555-4  0.298
2014 Hoppens MA, Sylvester CB, Qureshi AT, Scherr T, Czapski DR, Duran RS, Savage PB, Hayes D. Ceragenin mediated selectivity of antimicrobial silver nanoparticles. Acs Applied Materials & Interfaces. 6: 13900-8. PMID 25054867 DOI: 10.1021/Am504640F  0.297
2019 Pereira CS, Pérez-Cabezas B, Ribeiro H, Maia ML, Cardoso MT, Dias AF, Azevedo O, Ferreira MF, Garcia P, Rodrigues E, Castro-Chaves P, Martins E, Aguiar P, Pineda M, Amraoui Y, ... ... Savage PB, et al. Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients. Frontiers in Immunology. 10: 1264. PMID 31214199 DOI: 10.3389/Fimmu.2019.01264  0.297
2015 Vila-Farrés X, Callarisa AE, Gu X, Savage PB, Giralt E, Vila J. CSA-131, a ceragenin active against colistin-resistant Acinetobacter baumannii and Pseudomonas aeruginosa clinical isolates. International Journal of Antimicrobial Agents. PMID 26395218 DOI: 10.1016/J.Ijantimicag.2015.08.003  0.295
2005 Leung D, Streib J, Savage P, Howell M. Cationic steroid antibiotics (CSA) exhibit cytotoxic activity against vaccinia virus (VV) Journal of Allergy and Clinical Immunology. 115: S272. DOI: 10.1016/J.Jaci.2004.12.1096  0.294
1989 Mcdaniel CW, Bradshaw JS, Krakowiak KE, Izatt RM, Savage PB, Tarbet BJ, Bruening RL. Preparation of crown compounds containing allyloxymethyl or butenyl groups for attachment to silica gel or containing long chain lipophilic groups for use in liquid membrane systems Journal of Heterocyclic Chemistry. 26: 413-419. DOI: 10.1002/Jhet.5570260228  0.294
2007 Posner RG, Geng D, Haymore S, Bogert J, Pecht I, Licht A, Savage PB. Trivalent antigens for degranulation of mast cells. Organic Letters. 9: 3551-4. PMID 17691795 DOI: 10.1021/Ol071175H  0.294
2000 Bradshaw JS, Izatt RM, Savage PB, Bruening RL, Krakowiak KE. The Design of Ion Selective Macrocycles and the Solid-Phase Extraction of Ions Using Molecular Recognition Technology: A Synopsis Supramolecular Chemistry. 12: 23-26. DOI: 10.1080/10610270008029802  0.294
2007 Meyer EH, Wurbel MA, Staton TL, Pichavant M, Kan MJ, Savage PB, DeKruyff RH, Butcher EC, Campbell JJ, Umetsu DT. iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity. Journal of Immunology (Baltimore, Md. : 1950). 179: 4661-71. PMID 17878364 DOI: 10.4049/Jimmunol.179.7.4661  0.293
2014 Deng S, Bai L, Reboulet R, Matthew R, Engler DA, Teyton L, Bendelac A, Savage PB. A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses in vivo. Chemical Science (Royal Society of Chemistry : 2010). 5: 1437-1441. PMID 24683450 DOI: 10.1039/C3Sc53471E  0.293
2014 Savage PB. Vaccine development: NKT-cell adjuvants in conjugate. Nature Chemical Biology. 10: 882-3. PMID 25325698 DOI: 10.1038/Nchembio.1667  0.292
2002 Thomson J, Stoker J, Bunker J, Agbonkonkon N, Iyer G, Todd Bronson R, Savage PB, Linford MR, Husseini GA. Analysis of 5-chloro-8-methoxy-2-(bromomethyl)quinoline by XPS Surface Science Spectra. 9: 241-249. DOI: 10.1116/11.20030403  0.289
2002 Posner RG, Savage PB, Peters AS, Macias A, DelGado J, Zwartz G, Sklar LA, Hlavacek WS. A quantitative approach for studying IgE-FcepsilonRI aggregation. Molecular Immunology. 38: 1221-8. PMID 12217387 DOI: 10.1016/S0161-5890(02)00067-6  0.289
2001 Xue GP, Savage PB, Krakowiak KE, Izatt RM, Bradshaw JS. Synthesis of diazadibenzo-18-crown-6 ligands with appended chromophoric and fluorophoric groups as potential metal ion chemosensors Journal of Heterocyclic Chemistry. 38: 1453-1457. DOI: 10.1002/Jhet.5570380631  0.288
2015 Paletta D, Fichtner AS, Starick L, Porcelli SA, Savage PB, Herrmann T. Species Specific Differences of CD1d Oligomer Loading In Vitro. Plos One. 10: e0143449. PMID 26599805 DOI: 10.1371/Journal.Pone.0143449  0.287
1999 Su N, Bradshaw JS, Zhang XX, Savage PB, Krakowiak KE, Izatt RM. Syntheses of diaza-18-crown-6 ligands containing two units each of 4- hydroxyazobenzene, benzimidazole, uracil, anthraquinone, or ferrocene groups Journal of Heterocyclic Chemistry. 36: 771-775. DOI: 10.1002/Jhet.5570360332  0.286
2010 Nagant C, Tré-Hardy M, El-Ouaaliti M, Savage P, Devleeschouwer M, Dehaye JP. Interaction between tobramycin and CSA-13 on clinical isolates of Pseudomonas aeruginosa in a model of young and mature biofilms. Applied Microbiology and Biotechnology. 88: 251-63. PMID 20625718 DOI: 10.1007/S00253-010-2748-3  0.286
2001 Xue G, Bradshaw JS, Dalley NK, Savage PB, Krakowiak KE, Izatt RM, Prodi L, Montalti M, Zaccheroni N. Convenient syntheses and preliminary photophysical properties of novel 8-aminoquinoline appended diaza-18-crown-6 ligands Tetrahedron. 57: 7623-7628. DOI: 10.1016/S0040-4020(01)00746-3  0.285
2010 Epand RF, Pollard JE, Wright JO, Savage PB, Epand RM. Depolarization, bacterial membrane composition, and the antimicrobial action of ceragenins. Antimicrobial Agents and Chemotherapy. 54: 3708-13. PMID 20585129 DOI: 10.1128/Aac.00380-10  0.284
2019 Bandara N, Li Y, Diebolder P, Mpoy C, Gu X, Khanal P, Deng S, Rogers BE, Savage PB. Translation of ceragenin affinity for bacteria to an imaging reagent for infection. Rsc Advances. 9: 14472-14476. PMID 32864109 DOI: 10.1039/C9Ra02226K  0.284
2007 Bucki R, Sostarecz AG, Byfield FJ, Savage PB, Janmey PA. Resistance of the antibacterial agent ceragenin CSA-13 to inactivation by DNA or F-actin and its activity in cystic fibrosis sputum. The Journal of Antimicrobial Chemotherapy. 60: 535-45. PMID 17584802 DOI: 10.1093/Jac/Dkm218  0.283
2006 Prodi L, Dolci LS, Montalti M, Zaccheroni N, Farruggia G, Andreani G, Carpenè E, Iotti S, Savage PB, Trapani V, Sale P, Wolf FI. New fluorescent chemosensors for magnesium ions in living cells Progress in Biomedical Optics and Imaging - Proceedings of Spie. 6097. DOI: 10.1117/12.645783  0.282
2001 Song H, Chen Y, Song J, Savage PB, Xue G, Chiara JA, Izatt RM, Bradshaw JS, Krakowiak KE. New diazadi(and tri)thia-21-crown-7 ethers containing 8-hydroxyquinoline side arms Journal of Heterocyclic Chemistry. 38: 1369-1376. DOI: 10.1002/Jhet.5570380619  0.282
2008 Pichavant M, Goya S, Meyer EH, Johnston RA, Kim HY, Matangkasombut P, Zhu M, Iwakura Y, Savage PB, DeKruyff RH, Shore SA, Umetsu DT. Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. The Journal of Experimental Medicine. 205: 385-93. PMID 18250191 DOI: 10.1084/Jem.20071507  0.282
2000 Xue G, Bradshaw JS, Su N, Krakowiak KE, Savage PB, Izatt RM. Synthesis of two 1,3-2,4-calix[4]bis-crown ethers containing two 1,2-phenylene and one pyridine or anisole units in each crown ether moiety Journal of Heterocyclic Chemistry. 37: 1-3. DOI: 10.1002/Jhet.5570370101  0.282
2018 Hashemi MM, Rovig J, Holden BS, Taylor MF, Weber S, Wilson J, Hilton B, Zaugg AL, Ellis SW, Yost CD, Finnegan PM, Kistler CK, Berkow EL, Deng S, Lockhart SR, ... ... Savage PB, et al. Ceragenins are active against drug-resistant Candida auris clinical isolates in planktonic and biofilm forms. The Journal of Antimicrobial Chemotherapy. PMID 29635279 DOI: 10.1093/Jac/Dky085  0.281
2018 Hacioglu M, Guzel CB, Savage PB, Tan ASB. Antifungal susceptibilities, in vitro production of virulence factors and activities of ceragenins against Candida spp. isolated from vulvovaginal candidiasis. Medical Mycology. PMID 29846682 DOI: 10.1093/Mmy/Myy023  0.281
2009 LeszczyÅ„ska K, Namiot A, Fein DE, Wen Q, Namiot Z, Savage PB, Diamond S, Janmey PA, Bucki R. Bactericidal activities of the cationic steroid CSA-13 and the cathelicidin peptide LL-37 against Helicobacter pylori in simulated gastric juice. Bmc Microbiology. 9: 187. PMID 19728885 DOI: 10.1186/1471-2180-9-187  0.281
2006 Farruggia G, Iotti S, Prodi L, Montalti M, Zaccheroni N, Savage PB, Trapani V, Sale P, Wolf FI. 8-hydroxyquinoline derivatives as fluorescent sensors for magnesium in living cells. Journal of the American Chemical Society. 128: 344-50. PMID 16390164 DOI: 10.1021/Ja056523U  0.279
2003 Song HC, Chen YW, Yao JH, Xu ZL, Bradshaw JS, Savage PB, Izatt RM. Syntheses of diazadithiacrown ethers containing appended coumarin or 1-aminonaphthalene sidearms Journal of Heterocyclic Chemistry. 40: 475-479. DOI: 10.1002/Jhet.5570400311  0.278
2016 Vartabedian VF, Savage PB, Teyton L. The processing and presentation of lipids and glycolipids to the immune system. Immunological Reviews. 272: 109-19. PMID 27319346 DOI: 10.1111/Imr.12431  0.277
2014 Hoppens MA, Wheeler ZE, Qureshi AT, Hogan K, Wright A, Stanley GG, Young D, Savage P, Hayes D. Maghemite, silver, ceragenin conjugate particles for selective binding and contrast of bacteria. Journal of Colloid and Interface Science. 413: 167-74. PMID 24183446 DOI: 10.1016/J.Jcis.2013.09.016  0.276
2011 Trainor EA, Horton KE, Savage PB, Testerman TL, McGee DJ. Role of the HefC efflux pump in Helicobacter pylori cholesterol-dependent resistance to ceragenins and bile salts. Infection and Immunity. 79: 88-97. PMID 20974830 DOI: 10.1128/Iai.00974-09  0.275
2004 Zhou D, Cantu C, Sagiv Y, Schrantz N, Kulkarni AB, Qi X, Mahuran DJ, Morales CR, Grabowski GA, Benlagha K, Savage P, Bendelac A, Teyton L. Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins. Science (New York, N.Y.). 303: 523-7. PMID 14684827 DOI: 10.1126/Science.1092009  0.274
1999 Su N, Bradshaw JS, Zhang XX, Song H, Savage PB, Xue G, Krakowiak KE, Izatt RM. Syntheses and Metal Ion Complexation of Novel 8-Hydroxyquinoline-Containing Diaza-18-Crown-6 Ligands and Analogues. The Journal of Organic Chemistry. 64: 8855-8861. PMID 11674789 DOI: 10.1021/Jo991081O  0.274
2002 Xue G, Bradshaw JS, Dalley NK, Savage PB, Izatt RM, Prodi L, Montalti M, Zaccheroni N. The synthesis of azacrown ethers with quinoline-based sidearms as potential zinc(II) fluorophores Tetrahedron. 58: 4809-4815. DOI: 10.1016/S0040-4020(02)00451-9  0.273
1997 Paquette LA, Sun LQ, Friedrich D, Savage PB. Total synthesis of (+)-epoxydictymene. Application of alkoxy-directed cyclization to diterpenoid construction Journal of the American Chemical Society. 119: 8438-8450. DOI: 10.1021/Ja971526V  0.273
2008 Pichavant M, Goya S, Meyer E, Johnston R, Kim H, Matangkasombut P, Zhu M, Iwakura Y, Savage P, DeKruyff R, Shore S, Umetsu D. OR.94. Ozone Exposure in a Mouse Model Induces Airway Hyperreactivity That Requires the Presence of Natural Killer T Cells and IL-17 Clinical Immunology. 127. DOI: 10.1016/J.Clim.2008.03.101  0.272
2006 Bhairavabhotla RK, Tongaonkar H, Savage P, Chiplunkar S. F.121. Crosstalk of NKT-Cells and Regulatory T-Cells in Cervical Cancer Clinical Immunology. 119: S93. DOI: 10.1016/J.Clim.2006.04.161  0.271
2020 Mills RJ, Boyling A, Cheng TL, Peacock L, Savage PB, Tägil M, Little DG, Schindeler A. CSA-90 reduces periprosthetic joint infection in a novel rat model challenged with local and systemic Staphylococcus aureus. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 32009241 DOI: 10.1002/Jor.24618  0.271
2000 Xue GP, Bradshaw JS, Chiara JA, Savage PB, Krakowiak KE, Izatt RM, Prodi L, Montalti M, Zaccheroni N. A convenient synthesis of novel fluorophores: Macrocyclic polyamines containing two dansylamidoethyl side arms Synlett. 1181-1183. DOI: 10.1055/S-2000-6753  0.271
2001 Xue G, Bradshaw JS, Song H, Bronson RT, Savage PB, Krakowiak KE, Izatt RM, Prodi L, Montalti M, Zaccheroni N. A convenient synthesis and preliminary photophysical study of novel fluoroionophores: Macrocyclic polyamines containing two dansylamidoethyl side arms Tetrahedron. 57: 87-91. DOI: 10.1016/S0040-4020(00)00999-6  0.271
2001 Bradshaw JS, Song HC, Xue GP, Bronson RT, Chiara JA, Krakowiak KE, Savage PB, Izatt RM. Synthesis of Diazadi(and tri)thiacrown Ethers Containing, Two 5-Substituent(or 2-methyl)-8-hydroxyquinoline Side Arms Supramolecular Chemistry. 13: 499-508. DOI: 10.1080/10610270108029465  0.271
2013 Kim HY, Chang YJ, Chuang YT, Lee HH, Kasahara DI, Martin T, Hsu JT, Savage PB, Shore SA, Freeman GJ, Dekruyff RH, Umetsu DT. T-cell immunoglobulin and mucin domain 1 deficiency eliminates airway hyperreactivity triggered by the recognition of airway cell death. The Journal of Allergy and Clinical Immunology. 132: 414-25.e6. PMID 23672783 DOI: 10.1016/J.Jaci.2013.03.025  0.268
1998 Marshall RL, Dalley NK, Savage PB. Synthesis of novel 3',6'-dideoxy-3',6'-epithio and 2',6'-dideoxy-2',6'- epithio nucleosides Tetrahedron Letters. 39: 3923-3926. DOI: 10.1016/S0040-4039(98)00721-7  0.268
2019 Ghosh S, Joseph G, Korza G, He L, Yuan JH, Dong W, Setlow B, Li YQ, Savage PB, Setlow P. Effects of the microbicide ceragenin CSA-13 on and properties of Bacillus subtilis spores prepared on two very different media. Journal of Applied Microbiology. PMID 31067345 DOI: 10.1111/Jam.14300  0.266
2012 Bai L, Constantinides MG, Thomas SY, Reboulet R, Meng F, Koentgen F, Teyton L, Savage PB, Bendelac A. Distinct APCs explain the cytokine bias of α-galactosylceramide variants in vivo. Journal of Immunology (Baltimore, Md. : 1950). 188: 3053-61. PMID 22393151 DOI: 10.4049/Jimmunol.1102414  0.265
2009 Roohi S, Amir N, Mushtaq A, Savage PB, Salahuddin SM, Jehangir M. Preparation, quality control and biological evaluation of 99mTc-labelled cationic steroid antibiotic (CSA-13) Radiochimica Acta. 97: 57-62. DOI: 10.1524/Ract.2009.1572  0.264
2014 Tefit JN, Crabé S, Orlandini B, Nell H, Bendelac A, Deng S, Savage PB, Teyton L, Serra V. Efficacy of ABX196, a new NKT agonist, in prophylactic human vaccination. Vaccine. 32: 6138-45. PMID 25218293 DOI: 10.1016/J.Vaccine.2014.08.070  0.264
2006 Parent AA, Anderson TM, Michaelis DJ, Jiang G, Savage PB, Linford MR. Direct ToF-SIMS analysis of organic halides and amines on TLC plates Applied Surface Science. 252: 6746-6749. DOI: 10.1016/J.Apsusc.2006.02.166  0.264
2008 Fuangswasdi S, Kaveevivitchai N, Tuntulani T, Savage PB. Complexing properties of phenolic diazacrown ethers with transition and heavy metal ions Journal of Solution Chemistry. 37: 45-58. DOI: 10.1007/S10953-007-9218-2  0.263
2000 Su N, Bradshaw JS, Xue G, Dalley NK, Zhang XX, Savage PB, Krakowiak KE, Izatt RM. Syntheses, crystal structures, and metal ion complexation studies of novel diaza-18-crown-6 ligands containing aromatic thiol-derived side arms Journal of Heterocyclic Chemistry. 37: 711-718. DOI: 10.1002/Jhet.5570370407  0.259
2012 Kim HY, Chang YJ, Subramanian S, Lee HH, Albacker LA, Matangkasombut P, Savage PB, McKenzie AN, Smith DE, Rottman JB, DeKruyff RH, Umetsu DT. Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity. The Journal of Allergy and Clinical Immunology. 129: 216-27.e1-6. PMID 22119406 DOI: 10.1016/J.Jaci.2011.10.036  0.258
2005 Lua YY, Fillmore WJ, Yang L, Lee MV, Savage PB, Asplund MC, Linford MR. First reaction of a bare silicon surface with acid chlorides and a one-step preparation of acid chloride terminated monolayers on scribed silicon. Langmuir : the Acs Journal of Surfaces and Colloids. 21: 2093-7. PMID 15751991 DOI: 10.1021/La047338H  0.256
2001 Prodi L, Montalti M, Zaccheroni N, Bradshaw JS, Izatt RM, Savage PB. Characterization of 5-chloro-8-methoxyquinoline appended diaza-18-crown-6 as a chemosensor for cadmium Tetrahedron Letters. 42: 2941-2944. DOI: 10.1016/S0040-4039(01)00330-6  0.256
1999 Su N, Bradshaw JS, Zhang XX, Savage PB, Krakowiak KE, Izatt RM. Diaza-18-crown-6 ligands containing two aminophenol side arms: New heterobinuclear metal ion receptors Journal of Organic Chemistry. 64: 3825-3829. DOI: 10.1021/Jo9816212  0.255
2007 Sagiv Y, Bai L, Wei DG, Agami R, Savage PB, Teyton L, Bendelac A. A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d. The Journal of Experimental Medicine. 204: 921-8. PMID 17403933 DOI: 10.1084/Jem.20061568  0.254
2020 Iweala OI, Choudhary SK, Addison CT, Batty CJ, Kapita CM, Amelio C, Schuyler AJ, Deng S, Bachelder EM, Ainslie KM, Savage PB, Brennan PJ, Commins SP. Glycolipid-Mediated Basophil Activation in Alpha-Gal Allergy. The Journal of Allergy and Clinical Immunology. PMID 32088306 DOI: 10.1016/J.Jaci.2020.02.006  0.252
2008 HOWELL M, GENG D, STREIB J, SAVAGE P, LEUNG D. Ceragenins: A New Class of Anti-Vaccinia Viral Compounds Journal of Allergy and Clinical Immunology. 121: S271-S271. DOI: 10.1016/J.Jaci.2007.12.1075  0.252
2006 Meyer E, Wurbel M, Staton T, Savage P, Dekruyff R, Campbell J, Butcher E, Umetsu D. OR.49. INKt-Cells Require Ccr4 Binding of Ccl17 to Localize to the Airways Where They Are Necessary and Sufficient for Inducing Airway Hyperreactivity Clinical Immunology. 119: S22. DOI: 10.1016/J.Clim.2006.04.205  0.252
2011 Mohammed JP, Fusakio ME, Rainbow DB, Moule C, Fraser HI, Clark J, Todd JA, Peterson LB, Savage PB, Wills-Karp M, Ridgway WM, Wicker LS, Mattner J. Identification of Cd101 as a susceptibility gene for Novosphingobium aromaticivorans-induced liver autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). 187: 337-49. PMID 21613619 DOI: 10.4049/Jimmunol.1003525  0.251
2001 Lee SC, Izatt RM, Zhang XX, Nelson EG, Lamb JD, Savage PB, Bradshaw JS. Highly selective copper(II) ion receptors: Tetraazacrown ethers bearing two 8-hydroxyquinoline side arms Inorganica Chimica Acta. 317: 174-180. DOI: 10.1016/S0164-1212(00)00110-2  0.249
2002 Radicic N, Becerril-Garcia H, Myrer A, Cory E, Gertsch KR, Bronson RT, Savage PB, Linford MR, Husseini GA. Analysis of 10,16-Diaza-1,4,7,13-tetrathiacyclooctane-9,17-dione by XPS Surface Science Spectra. 9: 234-240. DOI: 10.1116/11.20030402  0.248
2004 Bronson RT, Montalti M, Prodi L, Zaccheroni N, Lamb RD, Dalley NK, Izatt RM, Bradshaw JS, Savage PB. Origins of 'on-off' fluorescent behavior of 8-hydroxyquinoline containing chemosensors Tetrahedron. 60: 11139-11144. DOI: 10.1016/J.Tet.2004.08.062  0.248
1988 Bradshaw JS, Krakowiak KE, Bruening RL, Tarbet BJ, Savage PB, Izatt RM. Synthesis of (allyloxy)methyl-substituted diaza-18-crown-6 compounds for attachment to silica gel Journal of Organic Chemistry. 53: 3190-3195. DOI: 10.1021/Jo00249A012  0.247
2010 Smith PA, Lepage CJ, Lukacs M, Martin N, Shufutinsky A, Savage PB. Field-portable gas chromatography with transmission quadrupole and cylindrical ion trap mass spectrometric detection: Chromatographic retention index data and ion/molecule interactions for chemical warfare agent identification International Journal of Mass Spectrometry. 295: 113-118. DOI: 10.1016/J.Ijms.2010.03.001  0.247
2010 Monine MI, Posner RG, Savage PB, Faeder JR, Hlavacek WS. Modeling multivalent ligand-receptor interactions with steric constraints on configurations of cell-surface receptor aggregates. Biophysical Journal. 98: 48-56. PMID 20085718 DOI: 10.1016/J.Bpj.2009.09.043  0.246
2001 Dalley NK, Xue G, Bradshaw JS, Xian Xin Zhang, Harrison RG, Savage PB, Krakowiak KE, Izatt RM. A new diaza-18-crown-6 ligand containing two quinolin-8-ylmethyl side arms: Crystal structures and characterization of the ligand, the protonated ligand and its mononuclear Barium(II) and dinuclear copper(II) complexes Journal of Heterocyclic Chemistry. 38: 1-9. DOI: 10.1002/Jhet.5570380101  0.245
2002 Kluchinsky TA, Sheely MV, Savage PB, Smith PA. Formation of 2-chlorobenzylidenemalononitrile (CS riot control agent) thermal degradation products at elevated temperatures. Journal of Chromatography. A. 952: 205-13. PMID 12064532 DOI: 10.1016/S0021-9673(02)00096-1  0.245
2007 Farruggia G, Iotti S, Prodi L, Montalti M, Zaccheroni N, Savage PB, Trapani V, Sale aP, Wolf FI. 8-Hydroxyquinoline Derivatives as Fluorescent Sensors for Magnesium in Living Cells [J. Am. Chem. Soc. 2006, 128, 344−350]. Journal of the American Chemical Society. 129: 1470-1470. DOI: 10.1021/Ja069973A  0.244
2019 Polonskaya Z, Savage PB, Finn MG, Teyton L. High-affinity anti-glycan antibodies: challenges and strategies. Current Opinion in Immunology. 59: 65-71. PMID 31029911 DOI: 10.1016/J.Coi.2019.03.004  0.242
2012 Pereira RL, Reis VO, Semedo P, Buscariollo BN, Donizetti-Oliveira C, Cenedeze MA, Soares MF, Pacheco-Silva A, Savage PB, Câmara NO, Keller AC. Invariant natural killer T cell agonist modulates experimental focal and segmental glomerulosclerosis. Plos One. 7: e32454. PMID 22427838 DOI: 10.1371/Journal.Pone.0032454  0.241
2020 Alehashem MS, Ariffin AB, Savage PB, Yehya Dabdawb WA, Thomas NF. Treasures old and new: what we can learn regarding the macrocyclic problem from past and present efforts in natural product total synthesis Rsc Advances. 10: 10989-11012. DOI: 10.1039/D0Ra01132K  0.238
2002 Kawakami J, Bronson R, Xue G, Bradshaw JS, Izatt RM, Savage PB. Erratum to ‘Characterization of bis-8-hydroxyquinoline-armed diazatrithia-16-crown-5 and diazadibenzo-18-crown-6 ligands as fluorescent chemosensors for zinc’ [Journal of Supramolecular Chemistry, 1 (2001) 221–227] Journal of Supramolecular Chemistry. 2: 537. DOI: 10.1016/S1472-7862(03)00092-3  0.237
2022 Oyardi O, Savage PB, Guzel CB. Effects of Ceragenins and Antimicrobial Peptides on the A549 Cell Line and an In Vitro Co-Culture Model of A549 Cells and . Pathogens (Basel, Switzerland). 11. PMID 36145476 DOI: 10.3390/pathogens11091044  0.237
2002 Hoggard J, Carlson ED, Frederickson SH, Monson CF, Gertsch KR, Bronson RT, Savage PB, Linford MR, Husseini GA. Analysis of 7,13-Bis((8-hydroxy-2-quinolinyl)methyl)-1,4-dimethyl-1,4,7,13-tetraaza-10-thiacyclopentadecane by XPS Surface Science Spectra. 9: 227-233. DOI: 10.1116/11.20030301  0.235
2001 Kluchinsky TA, Savage PB, Sheely MV, Thomas RJ, Smith PA. Identification of CS-derived compounds formed during heat-dispersion of CS riot control agent Journal of Microcolumn Separations. 13: 186-190. DOI: 10.1002/Mcs.1040  0.235
2011 Smith PA, Lepage CR, Savage PB, Bowerbank CR, Lee ED, Lukacs MJ. Use of a hand-portable gas chromatograph-toroidal ion trap mass spectrometer for self-chemical ionization identification of degradation products related to O-ethyl S-(2-diisopropylaminoethyl) methyl phosphonothiolate (VX). Analytica Chimica Acta. 690: 215-20. PMID 21435478 DOI: 10.1016/J.Aca.2011.02.026  0.234
2002 Kluchinsky TA, Savage PB, Fitz R, Smith PA. Liberation of hydrogen cyanide and hydrogen chloride during high-temperature dispersion of CS riot control agent. Aiha Journal : a Journal For the Science of Occupational and Environmental Health and Safety. 63: 493-6. PMID 12486784 DOI: 10.1080/15428110208984739  0.233
2019 Bozkurt Güzel Ç, Hacioğlu M, Inci G, Savage PB. Antibacterial and Antibiofilm Activities of Ceragenins against Clinical Isolates. Turkish Journal of Pharmaceutical Sciences. 16: 444-449. PMID 32454748 DOI: 10.4274/tjps.galenos.2018.59023  0.232
2020 Piktel E, Markiewicz KH, Wilczewska AZ, Daniluk T, Chmielewska S, Niemirowicz-Laskowska K, Mystkowska J, Paprocka P, Savage PB, Bucki R. Quantification of Synergistic Effects of Ceragenin CSA-131 Combined with Iron Oxide Magnetic Nanoparticles Against Cancer Cells. International Journal of Nanomedicine. 15: 4573-4589. PMID 32606693 DOI: 10.2147/Ijn.S255170  0.231
2003 Xue G, Bradshaw JS, Dalley NK, Savage PB, Izatt RM. Synthesis of trans-disubstituted cyclam ligands appended with two 6-hydroxymethylpyridin-2-ylmethyl sidearms: Crystal structures of the 1,8-dimethyl-4,11-di(6-hydroxymethylpyridin-2-ylmethyl)cylam ligand and its Co(II) and Ni(II) complexes Journal of Heterocyclic Chemistry. 40: 383-387. DOI: 10.1002/Jhet.5570400232  0.227
1998 Prodi L, Bolletta F, Montalti M, Zaccheroni N, Savage PB, Bradshaw JS, Izatt RM. A fluorescent sensor for magnesium ions Tetrahedron Letters. 39: 5451-5454. DOI: 10.1016/S0040-4039(98)01070-3  0.227
2022 Mitchell G, Silvis MR, Talkington KC, Budzik JM, Dodd CE, Paluba JM, Oki EA, Trotta KL, Licht DJ, Jimenez-Morales D, Chou S, Savage PB, Gross CA, Marletta MA, Cox JS. Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms. Mbio. e0272621. PMID 35073755 DOI: 10.1128/mbio.02726-21  0.226
2023 Skłodowski K, Suprewicz Ł, Chmielewska-Deptuła SJ, Kaliniak S, Okła S, Zakrzewska M, Minarowski Ł, Mróz R, Daniluk T, Savage PB, Fiedoruk K, Bucki R. Ceragenins exhibit bactericidal properties that are independent of the ionic strength in the environment mimicking cystic fibrosis sputum. Frontiers in Microbiology. 14: 1290952. PMID 38045035 DOI: 10.3389/fmicb.2023.1290952  0.225
2003 Hook GL, Kimm G, Betsinger G, Savage PB, Swift A, Logan T, Smith PA. Solid phase microextraction sampling and gas chromatography/mass spectrometry for field detection of the chemical warfare agent O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothiolate (VX) Journal of Separation Science. 26: 1091-1096. DOI: 10.1002/Jssc.200301561  0.22
2018 McConville J, Fringuelli E, Evans D, Savage P. First examination of the Lough Neagh European eel (Anguilla anguilla) population for eel virus European, eel virus European X and Anguillid Herpesvirus-1 infection by employing novel molecular techniques. Journal of Fish Diseases. PMID 30144086 DOI: 10.1111/Jfd.12885  0.22
2020 Choi J, Mele TS, Porcelli SA, Savage PB, Haeryfar SMM. Harnessing the Versatility of Invariant NKT Cells in a Stepwise Approach to Sepsis Immunotherapy. Journal of Immunology (Baltimore, Md. : 1950). PMID 33310870 DOI: 10.4049/jimmunol.2000220  0.219
2000 Prodi L, Bargossi C, Montalti M, Zaccheroni N, Su N, Bradshaw JS, Izatt RM, Savage PB. An effective fluorescent chemosensor for mercury ions [3] Journal of the American Chemical Society. 122: 6769-6770. DOI: 10.1021/Ja0006292  0.219
2020 Bozkurt Güzel Ç, Avci NM, Savage P. Activities of the Cationic Steroid Antibiotics CSA-13, CSA-131, CSA-138, CSA-142, and CSA-192 Against Carbapenem-resistant . Turkish Journal of Pharmaceutical Sciences. 17: 63-67. PMID 32454762 DOI: 10.4274/tjps.galenos.2018.26566  0.219
2002 Smith PA, Kluchinsky TA, Savage PB, Erickson RP, Lee AP, Williams K, Stevens M, Thomas RJ. Traditional sampling with laboratory analysis and solid phase microextraction sampling with field gas chromatography/mass spectrometry by military industrial hygienists. Aiha Journal : a Journal For the Science of Occupational and Environmental Health and Safety. 63: 284-92. PMID 12173177 DOI: 10.1080/15428110208984715  0.217
2013 Kuroda K, Fukuda T, Okumura K, Yoneyama H, Isogai H, Savage PB, Isogai E. Ceragenin CSA-13 induces cell cycle arrest and antiproliferative effects in wild-type and p53 null mutant HCT116 colon cancer cells. Anti-Cancer Drugs. 24: 826-34. PMID 23817390 DOI: 10.1097/CAD.0b013e3283634dd0  0.217
2023 Yilmaz FN, Öksüz L, Demir ES, Döşler S, Savage PB, Güzel ÇB. Efficacy of Ceragenins Alone and in Combinations with Antibiotics Against Multidrug-Resistant Gram Negative Pathogens from Bloodstream Infections. Current Microbiology. 80: 327. PMID 37620557 DOI: 10.1007/s00284-023-03443-5  0.215
2009 Isogai E, Isogai H, Takahashi K, Okumura K, Savage PB. Ceragenin CSA-13 exhibits antimicrobial activity against cariogenic and periodontopathic bacteria Oral Microbiology and Immunology. 24: 170-172. PMID 19239645 DOI: 10.1111/j.1399-302X.2008.00464.x  0.211
2003 Hook GL, Kimm G, Koch D, Savage PB, Ding B, Smith PA. Detection of VX contamination in soil through solid-phase microextraction sampling and gas chromatography/mass spectrometry of the VX degradation product bis(diisopropylaminoethyl)disulfide. Journal of Chromatography. A. 992: 1-9. PMID 12735457 DOI: 10.1016/S0021-9673(03)00278-4  0.209
2020 Damar-Çelik D, Mataracı-Kara E, Savage PB, Özbek-Çelik B. Antibacterial and antibiofilm activities of ceragenins against species isolated from cystic fibrosis patients. Journal of Chemotherapy (Florence, Italy). 1-12. PMID 32985386 DOI: 10.1080/1120009X.2020.1819702  0.208
2022 Paprocka P, Mańkowska A, Skłodowski K, Król G, Wollny T, Lesiak A, Głuszek K, Savage PB, Durnaś B, Bucki R. Bactericidal Activity of Ceragenin in Combination with Ceftazidime, Levofloxacin, Co-Trimoxazole, and Colistin against the Opportunistic Pathogen . Pathogens (Basel, Switzerland). 11. PMID 35745475 DOI: 10.3390/pathogens11060621  0.204
2023 Hacioglu M, Yilmaz FN, Oyardi O, Bozkurt Guzel C, Inan N, Savage PB, Dosler S. Antimicrobial Activity of Ceragenins against Vancomycin-Susceptible and -Resistant spp. Pharmaceuticals (Basel, Switzerland). 16. PMID 38139770 DOI: 10.3390/ph16121643  0.203
2017 Piktel E, Pogoda K, Savage PB, Bucki R. The search for new sporicidal agents for medical use: where are we? Future Microbiology. PMID 28593804 DOI: 10.2217/Fmb-2017-0069  0.201
2000 Fleming SA, Hart GR, Savage PB. Molecular Orbital Animations for Organic Chemistry Journal of Chemical Education. 77: 790-793. DOI: 10.1021/Ed077P790  0.2
2024 Wnorowska U, Łysik D, Piktel E, Zakrzewska M, Okła S, Lesiak A, Spałek J, Mystkowska J, Savage PB, Janmey P, Fiedoruk K, Bucki R. Ceragenin-mediated disruption of Pseudomonas aeruginosa biofilms. Plos One. 19: e0298112. PMID 38346040 DOI: 10.1371/journal.pone.0298112  0.199
2022 Wnorowska U, Piktel E, Deptuła P, Wollny T, Król G, Głuszek K, Durnaś B, Pogoda K, Savage PB, Bucki R. Ceragenin CSA-13 displays high antibacterial efficiency in a mouse model of urinary tract infection. Scientific Reports. 12: 19164. PMID 36357517 DOI: 10.1038/s41598-022-23281-y  0.198
2024 Costanzo A, Clarke D, Holt M, Sharma S, Nagy K, Tan X, Kain L, Abe B, Luce S, Boitard C, Wyseure T, Mosnier LO, Su AI, Grimes C, Finn MG, ... Savage PB, et al. Repositioning the Early Pathology of Type 1 Diabetes to the Extraislet Vasculature. Journal of Immunology (Baltimore, Md. : 1950). PMID 38426888 DOI: 10.4049/jimmunol.2300769  0.194
2023 Oyardi O, Eltimur T, Demir ES, Alkan B, Savage PB, Akcali A, Bozkurt-Guzel C. Antibacterial and Antibiofilm Activities of Ceragenins Alone and in Combination with Levofloxacin Against Multidrug Resistant Myroides spp. Clinical Isolates from Patients with Urinary Tract Infections. Current Microbiology. 80: 210. PMID 37191731 DOI: 10.1007/s00284-023-03321-0  0.193
2022 Demir ES, Oyardi O, Savage PB, Altay HO, Bozkurt-Guzel C. In vitro activity of ceragenins against Burkholderia cepacia complex. The Journal of Antibiotics. PMID 35562592 DOI: 10.1038/s41429-022-00530-w  0.192
2015 Siah A, Morrison DB, Fringuelli E, Savage P, Richmond Z, Johns R, Purcell MK, Johnson SC, Saksida SM. Piscine Reovirus: Genomic and Molecular Phylogenetic Analysis from Farmed and Wild Salmonids Collected on the Canada/US Pacific Coast. Plos One. 10: e0141475. PMID 26536673 DOI: 10.1371/Journal.Pone.0141475  0.189
2020 Chmielewska SJ, Skłodowski K, Piktel E, Suprewicz Ł, Fiedoruk K, Daniluk T, Wolak P, Savage PB, Bucki R. NDM-1 Carbapenemase-Producing Enterobacteriaceae are Highly Susceptible to Ceragenins CSA-13, CSA-44, and CSA-131. Infection and Drug Resistance. 13: 3277-3294. PMID 33061475 DOI: 10.2147/IDR.S261579  0.187
2011 Blumenfeld HJ, Tohn R, Haeryfar SM, Liu Y, Savage PB, Delovitch TL. Structure-guided design of an invariant natural killer T cell agonist for optimum protection from type 1 diabetes in non-obese diabetic mice. Clinical and Experimental Immunology. 166: 121-33. PMID 21910729 DOI: 10.1111/j.1365-2249.2011.04454.x  0.186
2021 Latorre MC, Pérez-Granda MJ, Savage PB, Alonso B, Martín-Rabadán P, Samaniego R, Bouza E, Muñoz P, Guembe M. Endotracheal tubes coated with a broad-spectrum antibacterial ceragenin reduce bacterial biofilm in an in vitro bench top model. The Journal of Antimicrobial Chemotherapy. PMID 33544817 DOI: 10.1093/jac/dkab019  0.186
2021 Kamble S, Valtchev P, Dao A, Pelras T, Rogers MJ, Savage PB, Dehghani F, Schindeler A. Synthesis and Characterization of Bone Binding Antibiotic-1 (BBA-1), a Novel Antimicrobial for Orthopedic Applications. Molecules (Basel, Switzerland). 26. PMID 33799713 DOI: 10.3390/molecules26061541  0.185
2023 Suprewicz Ł, Szczepański A, Lenart M, Piktel E, Fiedoruk K, Barreto-Duran E, Kula-Pacurar A, Savage PB, Milewska A, Bucki R, Pyrć K. Ceragenins exhibit antiviral activity against SARS-CoV-2 by increasing the expression and release of type I interferons upon activation of the host's immune response. Antiviral Research. 105676. PMID 37481038 DOI: 10.1016/j.antiviral.2023.105676  0.18
2023 Zaugg A, Sherren E, Yi R, Larsen T, Dyck B, Stump S, Pauga F, Linder A, Takara M, Gardner E, Shin S, Pulsipher J, Savage PB. Incorporating Ceragenins into Coatings Protects Peripherally Inserted Central Catheter Lines against Pathogen Colonization for Multiple Weeks. International Journal of Molecular Sciences. 24. PMID 37834369 DOI: 10.3390/ijms241914923  0.177
2023 Oyardi O, Demir ES, Alkan B, Komec S, Genc GE, Aygun G, Teke L, Turan D, Erturan Z, Savage PB, Guzel CB. Phenotypic Investigation of Virulence Factors, Susceptibility to Ceragenins, and the Impact of Biofilm Formation on Drug Efficacy in Isolates from Türkiye. Journal of Fungi (Basel, Switzerland). 9. PMID 37888282 DOI: 10.3390/jof9101026  0.174
2011 Yang Z, Gou S, Wu H, Zhao G, Hu X, Wang C, Shamseddine AI, Farhat FS, Matijević T, Kirinec G, Pavelić J, Sowunmi A, Okuboyejo TM, Gbotosho GO, Happi CT, ... ... Savage PB, et al. Contents Vol. 57, 2011 Chemotherapy. 57. DOI: 10.1159/000336031  0.171
2024 Czarnowski M, Słowińska M, Sawieljew M, Wnorowska U, Daniluk T, Król G, Karasiński M, Okła S, Savage PB, Piktel E, Bucki R. Efficacy of Ceragenins in Controlling the Growth of Oral Microorganisms: Implications for Oral Hygiene Management. Pharmaceuticals (Basel, Switzerland). 17. PMID 38399419 DOI: 10.3390/ph17020204  0.17
2005 Brimble M, Savage P. A Tribute to Don Cameron Arkivoc. 2001. DOI: 10.3998/Ark.5550190.0002.701  0.165
1999 Smith PA, Bowerbank CR, Savage PB, Drown DB, Lee ML, Alexander W, Jederberg WW, Still K. Conjugation of 7-oxodehydroabietic acid to lysine, a haptenation mechanism for an oxidized resin acid with dermal sensitizing properties. Applied Occupational and Environmental Hygiene. 14: 171-6. PMID 10453631 DOI: 10.1080/104732299303133  0.161
2016 Polat ZA, Cetin A, Savage PB. Evaluation of the in vitro activity of ceragenins against Trichomonas vaginalis. Acta Parasitologica / Witold StefańSki Institute of Parasitology, Warszawa, Poland. 61: 376-81. PMID 27078662 DOI: 10.1515/ap-2016-0049  0.16
2014 Bozkurt Guzel C, Tuysuz M, Inan N, Savage PB. Investigation of the Antifungal Activities of the Cationic Steroid Antibiotic CSA-8, CSA-13, CSA-44, CSA-131 and CSA-138 Against Candida albicans Isolated from Blood Cultures Ankem Dergisi. 28: 8-13. DOI: 10.5222/ANKEM.2014.008  0.16
2008 Savage PB, Nielsen J, Lai XZ, Feng Y, Li Y, Nelson G, Linford MR, Genberg C. Antibacterial activities of thin films containing ceragenins Acs Symposium Series. 984: 65-78. DOI: 10.1021/bk-2008-0984.ch005  0.16
2021 Paprocka P, Durnaś B, Mańkowska A, Skłodowski K, Król G, Zakrzewska M, Czarnowski M, Kot P, Fortunka K, Góźdź S, Savage PB, Bucki R. New β-Lactam Antibiotics and Ceragenins - A Study to Assess Their Potential in Treatment of Infections Caused by Multidrug-Resistant Strains of . Infection and Drug Resistance. 14: 5681-5698. PMID 34992394 DOI: 10.2147/IDR.S338827  0.157
2023 Prasad SV, Fiedoruk K, Zakrzewska M, Savage PB, Bucki R. Glyoxylate Shunt and Pyruvate-to-Acetoin Shift Are Specific Stress Responses Induced by Colistin and Ceragenin CSA-13 in Enterobacter hormaechei ST89. Microbiology Spectrum. e0121523. PMID 37338344 DOI: 10.1128/spectrum.01215-23  0.155
2014 Surel U, Niemirowicz K, Marzec M, Savage PB, Bucki R. Ceragenins – a new weapon to fight multidrug resistant bacterial infections Medical Studies. 3: 207-213. DOI: 10.5114/MS.2014.45428  0.152
2021 Chmielewska SJ, Skłodowski K, Depciuch J, Deptuła P, Piktel E, Fiedoruk K, Kot P, Paprocka P, Fortunka K, Wollny T, Wolak P, Parlinska-Wojtan M, Savage PB, Bucki R. Bactericidal Properties of Rod-, Peanut-, and Star-Shaped Gold Nanoparticles Coated with Ceragenin CSA-131 against Multidrug-Resistant Bacterial Strains. Pharmaceutics. 13. PMID 33809901 DOI: 10.3390/pharmaceutics13030425  0.151
2020 Jiang HY, Najmeh S, Martel G, MacFadden-Murphy E, Farias R, Savage P, Leone A, Roussel L, Cools-Lartigue J, Gowing S, Berube J, Giannias B, Bourdeau F, Chan CHF, Spicer JD, et al. Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis. Protein & Cell. PMID 31956962 DOI: 10.1007/S13238-019-00687-5  0.147
2020 Oyardi Ö, Savage PB, Erturan Z, Bozkurt-Guzel C. In vitro assessment of CSA-131 and CSA-131 poloxamer form for the treatment of Stenotrophomonas maltophilia infections in cystic fibrosis. The Journal of Antimicrobial Chemotherapy. PMID 33094334 DOI: 10.1093/jac/dkaa434  0.145
2015 Hina S, Rajoka MI, Savage PB, Roohi S, Bokhari TH. Labeling, quality control and biological evaluation of 99mTc-vibramycin for infection sites imaging Bulgarian Chemical Communications. 47: 747-754.  0.145
2022 Tokajuk J, Deptuła P, Chmielewska SJ, Skłodowski K, Mierzejewska ŻA, Grądzka-Dahlke M, Tołstoj A, Daniluk T, Paprocka P, Savage PB, Bucki R. Ceragenin CSA-44 as a Means to Control the Formation of the Biofilm on the Surface of Tooth and Composite Fillings. Pathogens (Basel, Switzerland). 11. PMID 35631012 DOI: 10.3390/pathogens11050491  0.145
2017 Hashemi MM, Holden BS, DurnaAA B, Buck R, Savage PB. Ceragenins as Mimics of Endogenous Antimicrobial Peptides Journal of Antimicrobial Agents. 3. DOI: 10.4172/2472-1212.1000141  0.141
2000 Xue GP, Bradshaw JS, Su N, Krakowiak KE, Savage PB, Izatt RM. Synthesis of two 1,3-2,4-calix[4]bis-crown ethers containing two 1,2- phenylene and one pyridine or anisole units in each crown ether moiety Journal of Heterocyclic Chemistry. 37: 1-3.  0.14
2021 Spałek J, Daniluk T, Godlewski A, Deptuła P, Wnorowska U, Ziembicka D, Cieśluk M, Fiedoruk K, Ciborowski M, Krętowski A, Góźdź S, Durnaś B, Savage PB, Okła S, Bucki R. Assessment of Ceragenins in Prevention of Damage to Voice Prostheses Caused by Biofilm Formation. Pathogens (Basel, Switzerland). 10. PMID 34832527 DOI: 10.3390/pathogens10111371  0.138
2021 Haynie T, Gubler S, Drees C, Heaton T, Mitton T, Gleave Q, Bendelac A, Deng S, Savage PB. Synthesis of the pentasaccharide repeating unit from and measurement of its inflammatory properties. Rsc Advances. 11: 14357-14361. PMID 35424013 DOI: 10.1039/d1ra01918j  0.136
2015 Wnorowska U, Niemirowicz K, Myint M, Diamond SL, Wróblewska M, Savage PB, Janmey PA, Bucki R. Bactericidal activities of cathelicidin LL-37 and select cationic lipids against the hypervirulent Pseudomonas aeruginosa strain LESB58 Antimicrobial Agents and Chemotherapy. 59: 3808-3815. DOI: 10.1128/AAC.00421-15  0.136
2023 Hodak CR, Bescucci DM, Shamash K, Kelly LC, Montina T, Savage PB, Inglis GD. Antimicrobial Growth Promoters Altered the Function but Not the Structure of Enteric Bacterial Communities in Broiler Chicks ± Microbiota Transplantation. Animals : An Open Access Journal From Mdpi. 13. PMID 36978538 DOI: 10.3390/ani13060997  0.134
2019 Durnaś B, Fiedoruk K, Cieśluk M, Deptuła P, Król G, Piktel E, Savage PB, Bucki R. Lysozyme increases bactericidal activity of ceragenin CSA-13 against Bacillus subtilis Medical Studies. 35: 1-9. DOI: 10.5114/MS.2019.83847  0.132
2023 Fahrenhorst-Jones T, Marshall D, Burns J, Pierens G, Van Meurs D, Kong D, Bernhardt P, Blanksby S, Savage P, Eaton P, Williams CM. 9-Azahomocubane. Chemistry (Weinheim An Der Bergstrasse, Germany). e202303133. PMID 37823679 DOI: 10.1002/chem.202303133  0.13
2019 Wnorowska U, Piktel E, Durnaś B, Savage P, Cieśluk M, Deptuła P, Bucki R. A place for ceragenis and LL-37 peptide in treatment of urinary tract infections Journal of Infection and Public Health. 12: 139. DOI: 10.1016/j.jiph.2018.10.106  0.128
2000 Su N, Bradshaw JS, Xue G, Dalley NK, Zhang XX, Savage PB, Krakowiak KE, Izatt RM. Syntheses, crystal structures, and metal ion complexation studies of novel diaza-18-crown-6 ligands containing aromatic thiol-derived side arms Journal of Heterocyclic Chemistry. 37: 711-718.  0.127
2000 Fowler CA, Perks CM, Newcomb PV, Savage PB, Farndon JR, Holly JM. Insulin-like growth factor binding protein-3 (IGFBP-3) potentiates paclitaxel-induced apoptosis in human breast cancer cells. International Journal of Cancer. Journal International Du Cancer. 88: 448-53. PMID 11054675 DOI: 10.1002/1097-0215(20001101)88:3<448::AID-IJC18>3.0.CO;2-V  0.127
1999 Su N, Bradshaw JS, Zhang XX, Song H, Savage PB, Xue G, Krakowiak KE, Izatt RM. Syntheses and metal ion complexation of novel 8-hydroxyquinoline- containing diaza-18-crown-6 ligands and analogues Journal of Organic Chemistry. 64: 8855-8861. DOI: 10.1021/jo991081o  0.122
1997 Savage PB, Thomas WD, Dalley NK. Journal of Inclusion Phenomena and Molecular Recognition in Chemistry. 29: 335-346. DOI: 10.1023/A:1007952822709  0.12
2021 Kirschbaum C, Greis K, Mucha E, Kain L, Deng S, Zappe A, Gewinner S, Schöllkopf W, von Helden G, Meijer G, Savage PB, Marianski M, Teyton L, Pagel K. Unravelling the structural complexity of glycolipids with cryogenic infrared spectroscopy. Nature Communications. 12: 1201. PMID 33619275 DOI: 10.1038/s41467-021-21480-1  0.119
2020 Alehashem MS, Ariffin AB, Savage PB, Yehya Dabdawb WA, Thomas NF. Treasures old and new: what we can learn regarding the macrocyclic problem from past and present efforts in natural product total synthesis. Rsc Advances. 10: 10989-11012. PMID 35495309 DOI: 10.1039/d0ra01132k  0.117
1997 Savage PB, Thomas WD, Dalley NK. Synthesis of two new glycophanes comprised of thioglucose molecules linked by hydrocarbons Journal of Inclusion Phenomena and Molecular Recognition in Chemistry. 29: 335-346.  0.113
1999 Yang Z, Bradshaw JS, Zhang XX, Savage PB, Krakowiak KE, Dalley NK, Su N, Todd Bronson R, Izatt RM. New tetraazacrown ethers containing two pyridine, quinoline, 8- hydroxyquinoline, or 8-aminoquinoline sidearms Journal of Organic Chemistry. 64: 3162-3170. DOI: 10.1021/jo982292g  0.11
2001 Song HC, Chen YW, Song JG, Savage PB, Xue GP, Chiara JA, Krakowiak KE, Izatt RM, Bradshaw JS. New diazadi(and tri)thia-21-crown-7 ethers containing 8-hydroxyquinoline side arms Journal of Heterocyclic Chemistry. 38: 1369-1376.  0.108
2021 Skłodowski K, Chmielewska SJ, Depciuch J, Deptuła P, Piktel E, Daniluk T, Zakrzewska M, Czarnowski M, Cieśluk M, Durnaś B, Parlińska-Wojtan M, Savage PB, Bucki R. Ceragenin-Coated Non-Spherical Gold Nanoparticles as Novel Candidacidal Agents. Pharmaceutics. 13. PMID 34834355 DOI: 10.3390/pharmaceutics13111940  0.106
2021 Cepeda Cañedo E, Totten S, Ahn R, Savage P, MacNeil D, Hudson J, Autexier C, Deblois G, Park M, Witcher M, Ursini-Siegel J. 66ShcA potentiates the cytotoxic response of triple negative breast cancers to PARP inhibitors. Jci Insight. PMID 33470989 DOI: 10.1172/jci.insight.138382  0.101
2016 Deblois G, Smith HW, Tam IS, Gravel SP, Caron M, Savage P, Labbé DP, Bégin LR, Tremblay ML, Park M, Bourque G, St-Pierre J, Muller WJ, Giguère V. ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer. Nature Communications. 7: 12156. PMID 27402251 DOI: 10.1038/Ncomms12156  0.101
2019 Bandara N, Li Y, Diebolder P, Mpoy C, Gu X, Khanal P, Deng S, Rogers BE, Savage PB. Translation of ceragenin affinity for bacteria to an imaging reagent for infection Rsc Advances. 9: 14472-14476. DOI: 10.1039/C9RA02226K  0.101
2018 Bernier C, Soliman A, Gravel M, Dankner M, Savage P, Petrecca K, Park M, Siegel PM, Shore GC, Roulston A. DZ-2384 has a superior preclinical profile to taxanes for the treatment of triple-negative breast cancer and is synergistic with anti-CTLA-4 immunotherapy. Anti-Cancer Drugs. PMID 29878901 DOI: 10.1097/Cad.0000000000000653  0.101
2013 Tahmasebi S, Ghorbani M, Savage P, Yan K, Gocevski G, Xiao L, You L, Yang XJ. Sumoylation of Krüppel-like factor 4 inhibits pluripotency induction but promotes adipocyte differentiation. The Journal of Biological Chemistry. 288: 12791-804. PMID 23515309 DOI: 10.1074/Jbc.M113.465443  0.098
2014 Tahmasebi S, Ghorbani M, Savage P, Gocevski G, Yang XJ. The SUMO conjugating enzyme Ubc9 is required for inducing and maintaining stem cell pluripotency. Stem Cells (Dayton, Ohio). 32: 1012-20. PMID 24706591 DOI: 10.1002/Stem.1600  0.098
2009 Nelson ML, Savage PB. Anti-Infective Agents in Medicinal Chemistry- hot topic: Fall of 2009 Anti-Infective Agents in Medicinal Chemistry. 8: 288-289. DOI: 10.2174/187152109789760153  0.095
1997 Paquette LA, Sun LQ, Friedrich D, Savage PB. Highly enantioselective total synthesis of natural epoxydictymene. An alkoxy-directed cyclization route to highly strained trans-oxabicyclo[3.3.0]octanes Tetrahedron Letters. 38: 195-198. DOI: 10.1016/S0040-4039(96)02287-3  0.093
2014 Zhao Y, Khanal P, Savage P, She YM, Cyr TD, Yang X. YAP-induced resistance of cancer cells to antitubulin drugs is modulated by a Hippo-independent pathway. Cancer Research. 74: 4493-503. PMID 24812269 DOI: 10.1158/0008-5472.CAN-13-2712  0.092
2021 Sung VYC, Knight JF, Johnson RM, Stern YE, Saleh SM, Savage P, Monast A, Zuo D, Duhamel S, Park M. Co-dependency for MET and FGFR1 in basal triple-negative breast cancers. Npj Breast Cancer. 7: 36. PMID 33772015 DOI: 10.1038/s41523-021-00238-4  0.089
2001 Dalley NK, Xue G, Bradshaw JS, Zhang XX, Harrison RG, Savage PB, Krakowiak KE, Izatt RM. A new diaza-18-crown-6 ligand containing two quinolin-8-ylmethyl side arms: Crystal structures and characterization of the ligand, the protonated ligand and its mononuclear barium(II) and dinuclear copper(II) complexes Journal of Heterocyclic Chemistry. 38: 1-9. DOI: 10.1002/jhet.5570380101  0.089
2003 Foulstone EJ, Savage PB, Crown AL, Holly JM, Stewart CE. Role of insulin-like growth factor binding protein-3 (IGFBP-3) in the differentiation of primary human adult skeletal myoblasts. Journal of Cellular Physiology. 195: 70-9. PMID 12599210 DOI: 10.1002/jcp.10227  0.088
2002 McCaig C, Fowler CA, Laurence NJ, Lai T, Savage PB, Holly JM, Perks CM. Differential interactions between IGFBP-3 and transforming growth factor-beta (TGF-beta) in normal vs cancerous breast epithelial cells. British Journal of Cancer. 86: 1963-9. PMID 12085194 DOI: 10.1038/sj.bjc.6600355  0.085
2001 Prodi L, Montalti M, Bradshaw JS, Izatt RM, Savage PB. Dependence on pH of the luminescent properties of metal ion complexes of 5-chloro-8-hydroxyquinoline appended diaza-18-crown-6 Journal of Inclusion Phenomena. 41: 123-127. DOI: 10.1023/A:1014490202475  0.084
1996 Hewin DF, Savage PB, Alderson D, Vipond MN. Plasminogen activators in oesophageal carcinoma British Journal of Surgery. 83: 1152-1155. PMID 8869332  0.083
2023 Nandi I, Smith HW, Sanguin-Gendreau V, Ji L, Pacis A, Papavasiliou V, Zuo D, Nam S, Attalla SS, Kim SH, Lusson S, Kuasne H, Fortier AM, Savage P, Martinez Ramirez C, et al. Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression. The Journal of Clinical Investigation. PMID 36795481 DOI: 10.1172/JCI162324  0.083
2021 Piktel E, Oscilowska I, Suprewicz Ł, Depciuch J, Marcińczyk N, Chabielska E, Wolak P, Głuszek K, Klimek J, Zieliński PM, Marzec MT, Savage PB, Parlińska-Wojtan M, Bucki R. Peanut-Shaped Gold Nanoparticles with Shells of Ceragenin CSA-131 Display the Ability to Inhibit Ovarian Cancer Growth In Vitro and in a Tumor Xenograft Model. Cancers. 13. PMID 34771587 DOI: 10.3390/cancers13215424  0.082
1999 Stewart CEH, Newcomb PV, Savage PB, Dickens M, Tavare J, Holly JMP. Increased, not decreased activation of the insulin-like growth factor (IGF) receptor signalling pathway during ceramide-induced apoptosis Growth Hormone and Igf Research. 9: 131-142. PMID 10373346 DOI: 10.1054/ghir.1999.0098  0.075
2020 Deblois G, Madani Tonekaboni SA, Grillo G, Martinez C, Kao YI, Tai F, Ettayebi I, Fortier AM, Savage P, Fedor AN, Liu X, Guilhamon P, Lima-Fernandes E, Murison A, Kuasne H, et al. Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer. Cancer Discovery. PMID 32546577 DOI: 10.1158/2159-8290.Cd-19-1493  0.072
2003 Foulstone EJ, Savage PB, Crown AL, Holly JM, Stewart CE. Adaptations of the IGF system during malignancy: human skeletal muscle versus the systemic environment. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et MéTabolisme. 35: 667-74. PMID 14710345 DOI: 10.1055/s-2004-814159  0.072
2004 Perks CM, Keith AJ, Goodhew KL, Savage PB, Winters ZE, Holly JM. Prolactin acts as a potent survival factor for human breast cancer cell lines. British Journal of Cancer. 91: 305-11. PMID 15213724 DOI: 10.1038/sj.bjc.6601947  0.071
2017 Savage P, Blanchet-Cohen A, Revil T, Badescu D, Saleh SMI, Wang YC, Zuo D, Liu L, Bertos NR, Munoz-Ramos V, Basik M, Petrecca K, Asselah J, Meterissian S, Guiot MC, et al. A Targetable EGFR-Dependent Tumor-Initiating Program in Breast Cancer. Cell Reports. 21: 1140-1149. PMID 29091754 DOI: 10.1016/J.Celrep.2017.10.015  0.071
1993 Savage PB, Gellman SH. Complexation of hexosammonium ions: Evidence for contributions from OH⋯OH hydrogen bonds in a hydroxylic medium Journal of the American Chemical Society. 115: 10448-10449.  0.069
2020 Savage P, Pacis A, Kuasne H, Liu L, Lai D, Wan A, Dankner M, Martinez C, Muñoz-Ramos V, Pilon V, Monast A, Zhao H, Souleimanova M, Annis MG, Aguilar-Mahecha A, et al. Chemogenomic profiling of breast cancer patient-derived xenografts reveals targetable vulnerabilities for difficult-to-treat tumors. Communications Biology. 3: 310. PMID 32546838 DOI: 10.1038/s42003-020-1042-x  0.069
2018 Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JF. The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression. Cell Reports. 23: 1476-1490. PMID 29719259 DOI: 10.1016/J.Celrep.2018.04.019  0.066
2021 Hjortaas MJ, Fringuelli E, Monjane AL, Mikalsen AB, Jonassen CM, Savage P, Sindre H. Emergence of Salmonid Alphavirus Genotype 2 in Norway-Molecular Characterization of Viral Strains Circulating in Norway and Scotland. Viruses. 13. PMID 34452421 DOI: 10.3390/v13081556  0.061
2021 Totten SP, Im YK, Cepeda Cañedo E, Najyb O, Nguyen A, Hébert S, Ahn R, Lewis K, Lebeau B, La Selva R, Sabourin V, Martínez C, Savage P, Kuasne H, Avizonis D, et al. STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer. Nature Communications. 12: 3299. PMID 34083537 DOI: 10.1038/s41467-021-23396-2  0.061
2021 Dankner M, Caron M, Al-Saadi T, Yu W, Ouellet V, Ezzeddine R, Maritan SM, Annis MG, Le PU, Nadaf J, Neubarth NS, Savage P, Zuo D, Couturier CP, Monlong J, et al. Invasive growth associated with Cold-Inducible RNA-Binding Protein expression drives recurrence of surgically resected brain metastases. Neuro-Oncology. PMID 33433612 DOI: 10.1093/neuonc/noab002  0.059
2024 Dankner M, Maritan SM, Priego N, Kruck G, Nkili-Meyong A, Nadaf J, Zhuang R, Annis MG, Zuo D, Nowakowski A, Biondini M, Kiepas A, Mourcos C, Le P, Charron F, ... ... Savage P, et al. Invasive growth of brain metastases is linked to CHI3L1 release from pSTAT3-positive astrocytes. Neuro-Oncology. PMID 38271182 DOI: 10.1093/neuonc/noae013  0.057
2018 Dankner M, Lajoie M, Moldoveanu D, Nguyen TT, Savage P, Rajkumar S, Huang X, Lvova M, Protopopov A, Vuzman D, Hogg D, Park M, Guiot MC, Petrecca K, Mihalcioiu C, et al. Dual MAPK inhibition is an effective therapeutic strategy for a subset of class II BRAF mutant melanoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29903896 DOI: 10.1158/1078-0432.Ccr-17-3384  0.056
2015 Tabariès S, Annis MG, Hsu BE, Tam CE, Savage P, Park M, Siegel PM. Lyn modulates Claudin-2 expression and is a therapeutic target for breast cancer liver metastasis. Oncotarget. 6: 9476-87. PMID 25823815 DOI: 10.18632/Oncotarget.3269  0.054
2022 Dao A, McDonald MM, Savage PB, Little DG, Schindeler A. Preventing osteolytic lesions and osteomyelitis in multiple myeloma. Journal of Bone Oncology. 37: 100460. PMID 36388641 DOI: 10.1016/j.jbo.2022.100460  0.052
2004 Zhang ZW, Newcomb PV, Moorghen M, Gupta J, Feakins R, Savage P, Hollowood A, Alderson D, Holly JM. Insulin-like growth factor binding protein-3: relationship to the development of gastric pre-malignancy and gastric adenocarcinoma (United Kingdom). Cancer Causes & Control : Ccc. 15: 211-8. PMID 15017134 DOI: 10.1023/B:CACO.0000019510.96285.e9  0.05
2016 Ahmad O, Chan M, Savage P, Watabe K, Lo HW, Qasem S. Biology and treatment of metastasis of sarcoma to the brain. Frontiers in Bioscience (Elite Edition). 8: 233-44. PMID 26709659 DOI: 10.2741/E764  0.049
2019 Smith HW, Hirukawa A, Sanguin-Gendreau V, Nandi I, Dufour CR, Zuo D, Tandoc K, Leibovitch M, Singh S, Rennhack JP, Swiatnicki M, Lavoie C, Papavasiliou V, Temps C, Carragher NO, ... ... Savage P, et al. An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis. Nature Communications. 10: 2901. PMID 31263101 DOI: 10.1038/S41467-019-10681-4  0.048
2002 Tomlinson SK, Melin SA, Higgs V, White DR, Savage P, Case D, Blackstock AW. Schedule-selective biochemical modulation of 5-fluorouracil in advanced colorectal cancer--a phase II study. Bmc Cancer. 2: 9. PMID 11988109  0.045
2003 Inman JL, Russell GB, Savage P, Levine EA. Low-dose adjuvant interferon for stage III malignant melanoma. The American Surgeon. 69: 127-30. PMID 12641352  0.044
2018 Hirukawa A, Smith HW, Zuo D, Dufour CR, Savage P, Bertos N, Johnson RM, Bui T, Bourque G, Basik M, Giguère V, Park M, Muller WJ. Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program. Nature Communications. 9: 2547. PMID 29959321 DOI: 10.1038/S41467-018-04864-8  0.043
2007 Miller AA, Case D, Harmon M, Savage P, Lesser G, Hurd D, Melin SA. Phase I study of lenalidomide in solid tumors. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 2: 445-9. PMID 17473661 DOI: 10.1097/01.Jto.0000268679.33238.67  0.04
2024 Sinicrope FA, Nelson GD, Saberzadeh-Ardestani B, Segovia DI, Graham RP, Wu C, Hagen CE, Shivji S, Savage P, Buchanan DD, Jenkins MA, Phipps AI, Swallow C, LeMarchand L, Gallinger S, et al. Use of deep learning to evaluate tumor microenvironmental features for prediction of colon cancer recurrence. Cancer Research Communications. PMID 38709069 DOI: 10.1158/2767-9764.CRC-24-0031  0.039
2019 Garfinkle R, Savage P, Boutros M, Landry T, Reynier P, Morin N, Vasilevsky CA, Filion KB. Incidence and predictors of postoperative ileus after loop ileostomy closure: a systematic review and meta-analysis. Surgical Endoscopy. PMID 31020433 DOI: 10.1007/s00464-019-06794-y  0.035
2005 Ben-Shlomo Y, Holly J, McCarthy A, Savage P, Davies D, Smith GD. Prenatal and Postnatal Milk Supplementation and Adult Insulin-like Growth Factor I: Long-term Follow-up of a Randomized Controlled Trial Cancer Epidemiology, Biomarkers & Prevention. 14: 1336-1339. PMID 15894699 DOI: 10.1158/1055-9965.Epi-04-0908  0.034
2023 Chowdhury W, Trail D, Miller M, Savage P. Eoarchean and Hadean melts reveal arc-like trace element and isotopic signatures. Nature Communications. 14: 1140. PMID 36854670 DOI: 10.1038/s41467-023-36538-5  0.034
2023 Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JF. The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression. Cell Reports. 42: 113604. PMID 38100352 DOI: 10.1016/j.celrep.2023.113604  0.028
2019 Deng Z, Chaussidon M, Savage P, Robert F, Pik R, Moynier F. Titanium isotopes as a tracer for the plume or island arc affinity of felsic rocks. Proceedings of the National Academy of Sciences of the United States of America. PMID 30606798 DOI: 10.1073/pnas.1809164116  0.017
2016 Datta M, Savage P, Lovato J, Schwartz GG. Serum calcium, albumin and tumor stage in cutaneous malignant melanoma. Future Oncology (London, England). PMID 27306120 DOI: 10.2217/fon-2016-0046  0.016
2019 Savage P, Yu N, Dumitra S, Meterissian S. The effect of the American Joint Committee on Cancer eighth edition on breast cancer staging and prognostication. Ejso. 45: 1817-1820. PMID 30926158 DOI: 10.1016/J.Ejso.2019.03.027  0.013
2016 Siah A, Morrison DB, Fringuelli E, Savage P, Richmond Z, Johns R, Purcell MK, Johnson SC, Saksida SM. Correction: Piscine Reovirus: Genomic and Molecular Phylogenetic Analysis from Farmed and Wild Salmonids Collected on the Canada/US Pacific Coast. Plos One. 11: e0164926. PMID 27732682 DOI: 10.1371/journal.pone.0164926  0.011
2024 Wu C, Pai RK, Kosiorek H, Banerjee I, Pfeiffer A, Hagen CE, Hartley CP, Graham RP, Sonbol MB, Bekaii-Saab T, Xie H, Sinicrope FA, Patel B, Westerling-Bui T, Shivji S, ... ... Savage P, et al. Improved risk stratification scheme for mismatch repair proficient stage II colorectal cancers using the digital pathology biomarker QuantCRC. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 38421684 DOI: 10.1158/1078-0432.CCR-23-3211  0.01
2017 Savage P. Economic and Logistic Challenges of Modern Oncology Healthcare. Clinical Oncology (Royal College of Radiologists (Great Britain)). 29: 547-549. PMID 28381368 DOI: 10.1016/j.clon.2017.03.009  0.01
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