Christopher R. Jacobs - Publications

Affiliations: 
Biomedical Engineering Columbia University, New York, NY 
Area:
Biomedical Engineering, Cell Biology, Medicine and Surgery

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Year Citation  Score
2023 Sutton MM, Duffy MP, Verbruggen SW, Jacobs CR. Osteoclastogenesis requires primary cilia disassembly and can be inhibited by promoting primary cilia formation pharmacologically. Cells, Tissues, Organs. PMID 37231815 DOI: 10.1159/000531098  0.402
2022 Spasic M, Duffy MP, Jacobs CR. Fenoldopam sensitizes primary cilia-mediated mechanosensing to promote osteogenic intercellular signaling and whole bone adaptation. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 35230705 DOI: 10.1002/jbmr.4536  0.402
2019 Moore ER, Chen JC, Jacobs CR. Prx1-Expressing Progenitor Primary Cilia Mediate Bone Formation in response to Mechanical Loading in Mice. Stem Cells International. 2019: 3094154. PMID 31814831 DOI: 10.1155/2019/3094154  0.539
2018 Moore ER, Yang Y, Jacobs CR. Primary cilia are necessary for Prx1-expressing cells to contribute to postnatal skeletogenesis. Journal of Cell Science. PMID 30002136 DOI: 10.1242/Jcs.217828  0.379
2018 Moore ER, Zhu YX, Ryu HS, Jacobs CR. Periosteal progenitors contribute to load-induced bone formation in adult mice and require primary cilia to sense mechanical stimulation. Stem Cell Research & Therapy. 9: 190. PMID 29996901 DOI: 10.1186/S13287-018-0930-1  0.52
2017 Moore ER, Jacobs CR. The primary cilium as a signaling nexus for growth plate function and subsequent skeletal development. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. PMID 28901584 DOI: 10.1002/Jor.23732  0.372
2017 Spasic M, Jacobs CR. Primary cilia: Cell and molecular mechanosensors directing whole tissue function. Seminars in Cell & Developmental Biology. PMID 28843978 DOI: 10.1016/J.Semcdb.2017.08.036  0.31
2017 Spasic M, Jacobs CR. Lengthening primary cilia enhances cellular mechanosensitivity. European Cells & Materials. 33: 158-168. PMID 28217833 DOI: 10.22203/Ecm.V033A12  0.324
2015 Chen JC, Hoey DA, Chua M, Bellon R, Jacobs CR. Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26675708 DOI: 10.1096/Fj.15-276402  0.508
2015 Nguyen AM, Young YN, Jacobs CR. The primary cilium is a self-adaptable, integrating nexus for mechanical stimuli and cellular signaling. Biology Open. PMID 26603473 DOI: 10.1016/J.Bpj.2014.11.2763  0.341
2015 Lee KL, Guevarra MD, Nguyen AM, Chua MC, Wang Y, Jacobs CR. The primary cilium functions as a mechanical and calcium signaling nexus. Cilia. 4: 7. PMID 26029358 DOI: 10.1186/S13630-015-0016-Y  0.318
2015 Duffy MP, Jacobs CR. Seeing the unseen: cell strain and mechanosensing. Biophysical Journal. 108: 1583-4. PMID 25863048 DOI: 10.1016/J.Bpj.2015.03.008  0.338
2015 Corrigan M, Lee K, Labour M, Jacobs C, Hoey D. Fluid flow-induced bending of the primary cilium triggers a distinct intraciliary calcium flux in mesenchymal stem cells Cilia. 4. DOI: 10.1186/2046-2530-4-S1-P22  0.382
2015 Spasic M, Jacobs C. Primary Cilia Length is Critical to Cellular Mechanotransduction Biophysical Journal. 108: 561a. DOI: 10.1016/J.Bpj.2014.11.3074  0.399
2014 Espinha LC, Hoey DA, Fernandes PR, Rodrigues HC, Jacobs CR. Oscillatory fluid flow influences primary cilia and microtubule mechanics. Cytoskeleton (Hoboken, N.J.). 71: 435-45. PMID 25044764 DOI: 10.1002/Cm.21183  0.393
2014 Lee KL, Hoey DA, Spasic M, Tang T, Hammond HK, Jacobs CR. Adenylyl cyclase 6 mediates loading-induced bone adaptation in vivo Faseb Journal. 28: 1157-1165. PMID 24277577 DOI: 10.1096/Fj.13-240432  0.504
2014 Downs ME, Nguyen AM, Herzog FA, Hoey DA, Jacobs CR. An experimental and computational analysis of primary cilia deflection under fluid flow. Computer Methods in Biomechanics and Biomedical Engineering. 17: 2-10. PMID 22452422 DOI: 10.1080/10255842.2011.653784  0.323
2013 Chen JC, Jacobs CR. Mechanically induced osteogenic lineage commitment of stem cells Stem Cell Research and Therapy. 4. PMID 24004875 DOI: 10.1186/Scrt318  0.409
2013 Leucht P, Temiyasathit S, Russell A, Arguello JF, Jacobs CR, Helms JA, Castillo AB. CXCR4 antagonism attenuates load-induced periosteal bone formation in mice. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 31: 1828-38. PMID 23881789 DOI: 10.1002/Jor.22440  0.512
2013 Nguyen AM, Jacobs CR. Emerging role of primary cilia as mechanosensors in osteocytes. Bone. 54: 196-204. PMID 23201223 DOI: 10.1016/J.Bone.2012.11.016  0.452
2013 Leucht P, Monica SD, Temiyasathit S, Lenton K, Manu A, Longaker MT, Jacobs CR, Spilker RL, Guo H, Brunski JB, Helms JA. Primary cilia act as mechanosensors during bone healing around an implant. Medical Engineering & Physics. 35: 392-402. PMID 22784673 DOI: 10.1016/J.Medengphy.2012.06.005  0.382
2013 Chen JC, Castillo AB, Jacobs CR. Cellular and Molecular Mechanotransduction in Bone Osteoporosis: Fourth Edition. 453-475. DOI: 10.1016/B978-0-12-415853-5.00020-0  0.342
2012 Castillo AB, Blundo JT, Chen JC, Lee KL, Yereddi NR, Jang E, Kumar S, Tang WJ, Zarrin S, Kim JB, Jacobs CR. Focal Adhesion Kinase Plays a Role in Osteoblast Mechanotransduction In Vitro but Does Not Affect Load-Induced Bone Formation In Vivo Plos One. 7. PMID 23028449 DOI: 10.1371/Journal.Pone.0043291  0.519
2012 Hoey DA, Tormey S, Ramcharan S, O'Brien FJ, Jacobs CR. Primary cilia-mediated mechanotransduction in human mesenchymal stem cells Stem Cells. 30: 2561-2570. PMID 22969057 DOI: 10.1002/Stem.1235  0.501
2012 Young YN, Downs M, Jacobs CR. Dynamics of the primary cilium in shear flow Biophysical Journal. 103: 629-639. PMID 22947924 DOI: 10.1016/J.Bpj.2012.07.009  0.304
2012 Hoey DA, Chen JC, Jacobs CR. The primary cilium as a novel extracellular sensor in bone. Frontiers in Endocrinology. 3: 75. PMID 22707948 DOI: 10.3389/Fendo.2012.00075  0.483
2012 Temiyasathit S, Tang WJ, Leucht P, Anderson CT, Monica SD, Castillo AB, Helms JA, Stearns T, Jacobs CR. Mechanosensing by the primary cilium: deletion of Kif3A reduces bone formation due to loading. Plos One. 7: e33368. PMID 22428034 DOI: 10.1371/Journal.Pone.0033368  0.493
2012 Hoey DA, Downs ME, Jacobs CR. The mechanics of the primary cilium: An intricate structure with complex function Journal of Biomechanics. 45: 17-26. PMID 21899847 DOI: 10.1016/J.Jbiomech.2011.08.008  0.384
2012 Hoey DA, Chen JC, Jacobs CR. The primary cilium as a novel extracellular sensor in bone Frontiers in Endocrinology. 3. DOI: 10.3389/fendo.2012.00075  0.385
2012 Jacobs C, Downs M, Nguyen A, Herzog F, Hoey D. Mechanical behavior of primary cilia. Cilia. 1: 27. DOI: 10.1186/2046-2530-1-S1-P27  0.333
2011 Lee HG, Minematsu H, Kim KO, Celil Aydemir AB, Shin MJ, Nizami SA, Chung KJ, Hsu AC, Jacobs CR, Lee FY. Actin and ERK1/2-CEBPβ signaling mediates phagocytosis-induced innate immune response of osteoprogenitor cells. Biomaterials. 32: 9197-206. PMID 21899882 DOI: 10.1016/J.Biomaterials.2011.08.059  0.355
2011 Hoey DA, Kelly DJ, Jacobs CR. A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells Biochemical and Biophysical Research Communications. 412: 182-187. PMID 21810408 DOI: 10.1016/J.Bbrc.2011.07.072  0.455
2011 Case N, Sen B, Thomas JA, Styner M, Xie Z, Jacobs CR, Rubin J. Steady and oscillatory fluid flows produce a similar osteogenic phenotype Calcified Tissue International. 88: 189-197. PMID 21165611 DOI: 10.1007/S00223-010-9448-Y  0.348
2011 Hoey DA, Jacobs CR. Oscillatory fluid flow affects the osteogenic differentiation of human bone marrow stromal cells in a primary cilium dependent manner Asme 2011 Summer Bioengineering Conference, Sbc 2011. 331-332. DOI: 10.1115/SBC2011-53435  0.374
2011 Jeon OH, Yoo YM, Kim KH, Jacobs CR, Kim CH. Primary cilia-mediated osteogenic response to fluid flow occurs via increases in focal adhesion and akt signaling pathway in MC3T3-E1 osteoblastic cells Cellular and Molecular Bioengineering. 4: 379-388. DOI: 10.1007/S12195-011-0191-X  0.435
2010 Tummala P, Arnsdorf EJ, Jacobs CR. The Role of Primary Cilia in Mesenchymal Stem Cell Differentiation: A Pivotal Switch in Guiding Lineage Commitment. Cellular and Molecular Bioengineering. 3: 207-212. PMID 20823950 DOI: 10.1007/S12195-010-0127-X  0.323
2010 Arnsdorf EJ, Tummala P, Castillo AB, Zhang F, Jacobs CR. The epigenetic mechanism of mechanically induced osteogenic differentiation Journal of Biomechanics. 43: 2881-2886. PMID 20728889 DOI: 10.1016/J.Jbiomech.2010.07.033  0.346
2010 Jacobs CR, Temiyasathit S, Castillo AB. Osteocyte mechanobiology and pericellular mechanics Annual Review of Biomedical Engineering. 12: 369-400. PMID 20617941 DOI: 10.1146/Annurev-Bioeng-070909-105302  0.387
2010 Castillo AB, Jacobs CR. Mesenchymal stem cell mechanobiology Current Osteoporosis Reports. 8: 98-104. PMID 20425617 DOI: 10.1007/S11914-010-0015-2  0.351
2010 Temiyasathit S, Jacobs CR. Osteocyte primary cilium and its role in bone mechanotransduction Annals of the New York Academy of Sciences. 1192: 422-428. PMID 20392268 DOI: 10.1111/J.1749-6632.2009.05243.X  0.506
2010 Kwon RY, Temiyasathit S, Tummala P, Quah CC, Jacobs CR. Primary cilium-dependent mechanosensing is mediated by adenylyl cyclase 6 and cyclic AMP in bone cells Faseb Journal. 24: 2859-2868. PMID 20371630 DOI: 10.1096/Fj.09-148007  0.459
2010 Kelly DJ, Jacobs CR. The role of mechanical signals in regulating chondrogenesis and osteogenesis of mesenchymal stem cells Birth Defects Research Part C - Embryo Today: Reviews. 90: 75-85. PMID 20301221 DOI: 10.1002/Bdrc.20173  0.351
2010 Litzenberger JB, Kim JB, Tummala P, Jacobs CR. β1 Integrins mediate mechanosensitive signaling pathways in Osteocytes Calcified Tissue International. 86: 325-332. PMID 20213106 DOI: 10.1007/S00223-010-9343-6  0.42
2010 Shivaram GM, Kim CH, Batra NN, Yang W, Harris SE, Jacobs CR. Novel early response genes in osteoblasts exposed to dynamic fluid flow. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 368: 605-16. PMID 20047941 DOI: 10.1098/Rsta.2009.0231  0.389
2010 Wang L, Shi X, Zhao R, Halloran BP, Clark DJ, Jacobs CR, Kingery WS. Calcitonin-gene-related peptide stimulates stromal cell osteogenic differentiation and inhibits RANKL induced NF-kappaB activation, osteoclastogenesis and bone resorption. Bone. 46: 1369-79. PMID 19962460 DOI: 10.1016/J.Bone.2009.11.029  0.459
2010 Lee KL, Hoey DA, Jacobs CR. Primary cilia-mediated mechanotransduction in bone Clinical Reviews in Bone and Mineral Metabolism. 8: 201-212. DOI: 10.1007/S12018-010-9078-Y  0.469
2009 Kim CH, Kim KH, Jacobs CR. Effects of high frequency loading on RANKL and OPG mRNA expression in ST-2 murine stromal cells Bmc Musculoskeletal Disorders. 10. PMID 19728893 DOI: 10.1186/1471-2474-10-109  0.445
2009 Arnsdorf EJ, Tummala P, Jacobs CR. Non-canonical Wnt signalling and N-cadherin related β-catenin signalling play a role in mechanically induced osteogenic cell fate Plos One. 4. PMID 19401766 DOI: 10.1371/Journal.Pone.0005388  0.397
2009 Wang L, Zhao R, Shi X, Wei T, Halloran BP, Clark DJ, Jacobs CR, Kingery WS. Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro. Bone. 45: 309-20. PMID 19379851 DOI: 10.1016/J.Bone.2009.04.203  0.453
2009 Folgado J, Fernandes PR, Jacobs CR, Pellegrini JD. Influence of femoral stem geometry, material and extent of porous coating on bone ingrowth and atrophy in cementless total hip arthroplasty: an iterative finite element model Computer Methods in Biomechanics and Biomedical Engineering. 12: 135-145. PMID 19242833 DOI: 10.1080/10255840802546754  0.464
2009 Arnsdorf EJ, Jones LM, Carter DR, Jacobs CR. The periosteum as a cellular source for functional tissue engineering. Tissue Engineering. Part A. 15: 2637-42. PMID 19207046 DOI: 10.1089/Ten.Tea.2008.0244  0.517
2009 Arnsdorf EJ, Tummala P, Kwon RY, Jacobs CR. Mechanically induced osteogenic differentiation - The role of RhoA, ROCKII and cytoskeletal dynamics Journal of Cell Science. 122: 546-553. PMID 19174467 DOI: 10.1242/Jcs.036293  0.369
2009 Riboh J, Chong AKS, Pham H, Longaker M, Jacobs C, Chang J. Optimization of Flexor Tendon Tissue Engineering With a Cyclic Strain Bioreactor Journal of Hand Surgery (European Volume). 33: 1388-1396. PMID 18929207 DOI: 10.1016/J.Jhsa.2008.04.019  0.315
2009 Litzenberger JB, Tang WJ, Castillo AB, Jacobs CR. Deletion of β1 integrins from cortical osteocytes reduces load-induced bone formation Cellular and Molecular Bioengineering. 2: 416-424. DOI: 10.1007/S12195-009-0068-4  0.455
2009 Kwon RY, Temiyasathit S, Tummala P, Quah C, Jacobs CR. Primary cilia mediate intracellular cAMP responses in bone cells exposed to dynamic fluid flow Proceedings of the Asme Summer Bioengineering Conference, Sbc2008. 321-322.  0.35
2008 Nelson ER, Huang Z, Ma T, Lindsey D, Jacobs C, Smith RL, Goodman SB. New bone formation by murine osteoprogenitor cells cultured on corticocancellous allograft bone. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 26: 1660-4. PMID 18524004 DOI: 10.1002/jor.20676  0.372
2008 You L, Temiyasathit S, Lee P, Kim CH, Tummala P, Yao W, Kingery W, Malone AM, Kwon RY, Jacobs CR. Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading. Bone. 42: 172-9. PMID 17997378 DOI: 10.1016/J.Bone.2007.09.047  0.521
2008 Sabsovich I, Clark JD, Liao G, Peltz G, Lindsey DP, Jacobs CR, Yao W, Guo TZ, Kingery WS. Bone microstructure and its associated genetic variability in 12 inbred mouse strains: microCT study and in silico genome scan. Bone. 42: 439-51. PMID 17967568 DOI: 10.1016/J.Bone.2007.09.041  0.408
2008 Malone AMD, Anderson CT, Tummala P, Kwon RY, Johnston TR, Stearns T, Jacobs CR. Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism (Proceedings of the National Academy of Sciences of the United States of America (2007) 104, (13325-13330) DOI: 10.1073/pnas.0700636104) Proceedings of the National Academy of Sciences of the United States of America. 105: 825. DOI: 10.1073/Pnas.0711497105  0.406
2008 Malone A, Anderson C, Sterns T, Jacobs C. Primary cilia as mechanosensors in bone Bone. 43: S53-S54. DOI: 10.1016/J.Bone.2008.08.045  0.467
2008 You L, Temiyasathit S, Coyer SR, García AJ, Jacobs CR. Bone Cells Grown on Micropatterned Surfaces are More Sensitive to Fluid Shear Stress Cellular and Molecular Bioengineering. 1: 182-188. DOI: 10.1007/S12195-008-0017-7  0.474
2008 You L, Temiyasathit S, Tao E, Prinz F, Jacobs CR. 3D Microfluidic Approach to Mechanical Stimulation of Osteocyte Processes Cellular and Molecular Bioengineering. 1: 103-107. DOI: 10.1007/S12195-008-0010-1  0.511
2007 Malone AM, Anderson CT, Stearns T, Jacobs CR. Primary cilia in bone. Journal of Musculoskeletal & Neuronal Interactions. 7: 301. PMID 18094482  0.366
2007 Malone AM, Anderson CT, Tummala P, Kwon RY, Johnston TR, Stearns T, Jacobs CR. Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism. Proceedings of the National Academy of Sciences of the United States of America. 104: 13325-30. PMID 17673554 DOI: 10.1073/Pnas.0700636104  0.53
2007 Kwon RY, Jacobs CR. Time-dependent deformations in bone cells exposed to fluid flow in vitro: investigating the role of cellular deformation in fluid flow-induced signaling Journal of Biomechanics. 40: 3162-3168. PMID 17559856 DOI: 10.1016/J.Jbiomech.2007.04.003  0.466
2007 Malone AM, Batra NN, Shivaram G, Kwon RY, You L, Kim CH, Rodriguez J, Jair K, Jacobs CR. The role of actin cytoskeleton in oscillatory fluid flow-induced signaling in MC3T3-E1 osteoblasts. American Journal of Physiology. Cell Physiology. 292: C1830-6. PMID 17251324 DOI: 10.1152/Ajpcell.00352.2005  0.389
2007 Godin LM, Suzuki S, Jacobs CR, Donahue HJ, Donahue SW. Mechanically induced intracellular calcium waves in osteoblasts demonstrate calcium fingerprints in bone cell mechanotransduction. Biomechanics and Modeling in Mechanobiology. 6: 391-8. PMID 17082961 DOI: 10.1007/S10237-006-0059-5  0.345
2006 Kim CH, You L, Yellowley CE, Jacobs CR. Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling. Bone. 39: 1043-7. PMID 16860618 DOI: 10.1016/J.Bone.2006.05.017  0.513
2006 Rubin J, Rubin C, Jacobs CR. Molecular pathways mediating mechanical signaling in bone. Gene. 367: 1-16. PMID 16361069 DOI: 10.1016/J.Gene.2005.10.028  0.454
2006 Clowes-Arnsdorf EJ, Kwon RY, Tummala P, Carter DR, Jacobs CR. The role of actin cytoskeletal tension in oscillatory fluid flow induced osteogenesis McB Molecular and Cellular Biomechanics. 3: 205-206.  0.501
2005 Batra NN, Li YJ, Yellowley CE, You L, Malone AM, Kim CH, Jacobs CR. Effects of short-term recovery periods on fluid-induced signaling in osteoblastic cells. Journal of Biomechanics. 38: 1909-17. PMID 16023480 DOI: 10.1016/J.Jbiomech.2004.08.009  0.512
2005 Offley SC, Guo TZ, Wei T, Clark JD, Vogel H, Lindsey DP, Jacobs CR, Yao W, Lane NE, Kingery WS. Capsaicin-sensitive sensory neurons contribute to the maintenance of trabecular bone integrity Journal of Bone and Mineral Research. 20: 257-267. PMID 15647820 DOI: 10.1359/Jbmr.041108  0.415
2005 Malone AM, Narain R, Jacobs CR. Biomechanical regulation of mesenchymal stem and progenitor cells and the implications for regenerative medicine Current Opinion in Orthopaedics. 16: 363-367. DOI: 10.1097/01.Bco.0000178253.32694.F3  0.404
2004 Li YJ, Batra NN, You L, Meier SC, Coe IA, Yellowley CE, Jacobs CR. Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 22: 1283-9. PMID 15475210 DOI: 10.1016/J.Orthres.2004.04.002  0.506
2004 Haut Donahue TL, Genetos DC, Jacobs CR, Donahue HJ, Yellowley CE. Annexin V disruption impairs mechanically induced calcium signaling in osteoblastic cells Bone. 35: 656-663. PMID 15336601 DOI: 10.1016/J.Bone.2004.04.025  0.461
2003 Kingery WS, Offley SC, Guo TZ, Davies MF, Clark JD, Jacobs CR. A substance P receptor (NK1) antagonist enhances the widespread osteoporotic effects of sciatic nerve section Bone. 33: 927-936. PMID 14678852 DOI: 10.1016/J.Bone.2003.07.003  0.355
2003 Reilly GC, Haut TR, Yellowley CE, Donahue HJ, Jacobs CR. Fluid flow induced PGE2 release by bone cells is reduced by glycocalyx degradation whereas calcium signals are not. Biorheology. 40: 591-603. PMID 14610310  0.327
2003 Alford AI, Jacobs CR, Donahue HJ. Oscillating fluid flow regulates gap junction communication in osteocytic MLO-Y4 cells by an ERK1/2 MAP kinase-dependent mechanism Bone. 33: 64-70. PMID 12919700 DOI: 10.1016/S8756-3282(03)00167-4  0.317
2003 Donahue TLH, Haut TR, Yellowley CE, Donahue HJ, Jacobs CR. Mechanosensitivity of bone cells to oscillating fluid flow induced shear stress may be modulated by chemotransport Journal of Biomechanics. 36: 1363-1371. PMID 12893045 DOI: 10.1016/S0021-9290(03)00118-0  0.412
2003 Saunders MM, You J, Zhou Z, Li Z, Yellowley CE, Kunze EL, Jacobs CR, Donahue HJ. Fluid flow-induced prostaglandin E2 response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium Bone. 32: 350-356. PMID 12689677 DOI: 10.1016/S8756-3282(03)00025-5  0.48
2003 Donahue SW, Donahue HJ, Jacobs CR. Osteoblastic cells have refractory periods for fluid-flow-induced intracellular calcium oscillations for short bouts of flow and display multiple low-magnitude oscillations during long-term flow. Journal of Biomechanics. 36: 35-43. PMID 12485636 DOI: 10.1016/S0021-9290(02)00318-4  0.394
2003 Haut Donahue TL, Hull ML, Rashid MM, Jacobs CR. How the stiffness of meniscal attachments and meniscal material properties affect tibio-femoral contact pressure computed using a validated finite element model of the human knee joint. Journal of Biomechanics. 36: 19-34. PMID 12485635 DOI: 10.1016/S0021-9290(02)00305-6  0.312
2002 You J, Jacobs CR, Steinberg TH, Donahue HJ. P2Y purinoceptors are responsible for oscillatory fluid flow-induced intracellular calcium mobilization in osteoblastic cells. The Journal of Biological Chemistry. 277: 48724-9. PMID 12376532 DOI: 10.1074/Jbc.M209245200  0.308
2002 Donahue TL, Hull ML, Rashid MM, Jacobs CR. A finite element model of the human knee joint for the study of tibio-femoral contact. Journal of Biomechanical Engineering. 124: 273-80. PMID 12071261 DOI: 10.1115/1.1470171  0.363
2002 Fernandes PR, Folgado J, Jacobs C, Pellegrini V. A contact model with ingrowth control for bone remodelling around cementless stems. Journal of Biomechanics. 35: 167-76. PMID 11784535 DOI: 10.1016/S0021-9290(01)00204-4  0.494
2002 Buhl KM, Jacobs CR, Turner RT, Evans GL, Farrell PA, Donahue HJ. Parallel changes in extracellular matrix protein gene expression, bone formation and biomechanical properties in aging rat bone Journal of Musculoskeletal Research. 6: 157-169. DOI: 10.1142/S0218957702000848  0.455
2002 Jacobs CR. Bone mechanics handbook (second edition) Journal of Biomechanics. 35: 723-724. DOI: 10.1016/S0021-9290(01)00251-2  0.474
2001 Saunders MM, You J, Trosko JE, Yamasaki H, Li Z, Donahue HJ, Jacobs CR. Gap junctions and fluid flow response in MC3T3-E1 cells American Journal of Physiology - Cell Physiology. 281. PMID 11698250 DOI: 10.1152/Ajpcell.2001.281.6.C1917  0.371
2001 Donahue SW, Jacobs CR, Donahue HJ. Flow-induced calcium oscillations in rat osteoblasts are age, loading frequency, and shear stress dependent American Journal of Physiology - Cell Physiology. 281: C1635-C1641. PMID 11600427 DOI: 10.1152/Ajpcell.2001.281.5.C1635  0.478
2001 Edlich M, Yellowley CE, Jacobs CR, Donahue HJ. Oscillating fluid flow regulates cytosolic calcium concentration in bovine articular chondrocytes Journal of Biomechanics. 34: 59-65. PMID 11425081 DOI: 10.1016/S0021-9290(00)00158-5  0.333
2001 You J, Reilly GC, Zhen X, Yellowley CE, Chen Q, Donahue HJ, Jacobs CR. Osteopontin Gene Regulation by Oscillatory Fluid Flow via Intracellular Calcium Mobilization and Activation of Mitogen-activated Protein Kinase in MC3T3-E1 Osteoblasts Journal of Biological Chemistry. 276: 13365-13371. PMID 11278573 DOI: 10.1074/Jbc.M009846200  0.388
2001 Kurokouchi K, Jacobs CR, Donahue HJ. Oscillating Fluid Flow Inhibits TNF-α-induced NF-κB Activation via an IκB Kinase Pathway in Osteoblast-like UMR106 Cells Journal of Biological Chemistry. 276: 13499-13504. PMID 11096064 DOI: 10.1074/Jbc.M003795200  0.301
2001 Jacobs CR, You J, Reilly G, Saunders MM, Kurokouchi K, Yellowley CE, Donahue HJ. An overview of oscialltory fluid flow as a potent loading-induced physical signal in bone cells American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 50: 339-340.  0.352
2000 Black KP, Saunders MM, Stube KC, Moulton MJR, Jacobs CR. Effects of interference fit screw length on tibial tunnel fixation for anterior cruciate ligament reconstruction American Journal of Sports Medicine. 28: 846-849. PMID 11101107 DOI: 10.1177/03635465000280061201  0.346
2000 You J, Yellowley CE, Donahue HJ, Zhang Y, Chen Q, Jacobs CR. Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow Journal of Biomechanical Engineering. 122: 387-393. PMID 11036562 DOI: 10.1115/1.1287161  0.484
2000 Lesh ML, Schneider DJ, Deol G, Davis B, Jacobs CR, Pellegrini V.D. J. The consequences of anterior femoral notching in total knee arthroplasty: A Biomechanical study Journal of Bone and Joint Surgery - Series A. 82: 1096-1101. PMID 10954098 DOI: 10.2106/00004623-200008000-00005  0.316
2000 Eckstein F, Merz B, Jacobs CR. Effects of joint incongruity on articular pressure distribution and subchondral bone remodeling Advances in Anatomy, Embryology, and Cell Biology. 152. PMID 10857219  0.307
2000 Jacobs CR. The mechanobiology of cancellous bone structural adaptation Journal of Rehabilitation Research and Development. 37: 209-216. PMID 10850827  0.407
2000 Malecki EA, Buhl KM, Beard JL, Jacobs CR, Connor JR, Donahue HJ. Bone structural and mechanical properties are affected by hypotransferrinemia but not by iron deficiency in mice Journal of Bone and Mineral Research. 15: 271-277. PMID 10703928 DOI: 10.1359/Jbmr.2000.15.2.271  0.333
2000 Yellowley CE, Li Z, Zhou Z, Jacobs CR, Donahue HJ. Functional gap junctions between osteocytic and osteoblastic cells Journal of Bone and Mineral Research. 15: 209-217. PMID 10703922 DOI: 10.1359/Jbmr.2000.15.2.209  0.39
2000 Yellowley C, Zhang Y, Jacobs C, Donahue H. Oscillating fluid flow increases calcium and annexin V MRNA expression in bone cells Bone. 27: 37. DOI: 10.1016/S8756-3282(00)80129-5  0.415
2000 Jacobs C, You J, Yellowley C, Donahue H. Mechanotransduction in bone cells via oscillating flow Bone. 27: 16. DOI: 10.1016/S8756-3282(00)80046-0  0.459
1999 Fischer KJ, Jacobs CR, Levenston ME, Cody DD, Carter DR. Proximal Femoral Density Patterns are Consistent with Bicentric Joint Loads. Computer Methods in Biomechanics and Biomedical Engineering. 2: 271-283. PMID 11264832 DOI: 10.1080/10255849908907992  0.709
1999 Fernandes P, Rodrigues H, Jacobs C. A Model of Bone Adaptation Using a Global Optimisation Criterion Based on the Trajectorial Theory of Wolff. Computer Methods in Biomechanics and Biomedical Engineering. 2: 125-138. PMID 11264822 DOI: 10.1080/10255849908907982  0.446
1999 Jacobs CR, Davis BR, Rieger CJ, Francis JJ, Saad M, Fyhrie DP. NACOB presentation to ASB Young Scientist Award: Postdoctoral. The impact of boundary conditions and mesh size on the accuracy of cancellous bone tissue modulus determination using large-scale finite-element modeling. North American Congress on Biomechanics. Journal of Biomechanics. 32: 1159-64. PMID 10541065 DOI: 10.1016/S0021-9290(99)00115-3  0.609
1999 Yellowley CE, Jacobs CR, Donahue HJ. Mechanisms contributing to fluid-flow-induced Ca2+ mobilization in articular chondrocytes Journal of Cellular Physiology. 180: 402-408. PMID 10430180 DOI: 10.1002/(Sici)1097-4652(199909)180:3<402::Aid-Jcp11>3.0.Co;2-4  0.314
1999 Eckstein F, Merz B, Schön M, Jacobs CR, Putz R. Tension and bending, but not compression alone determine the functional adaptation of subchondral bone in incongruous joints Anatomy and Embryology. 199: 85-97. PMID 9924938 DOI: 10.1007/S004290050212  0.423
1999 You J, Yellowley CE, Donahue HJ, Jacobs CR. Physiological levels of substrate deformation are less stimulatory to bone cells compared to fluid flow American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 43: 161-162.  0.359
1998 Fischer KJ, Jacobs CR, Levenston ME, Cody DD, Carter DR. Bone Load Estimation for the Proximal Femur Using Single Energy Quantitative CT Data. Computer Methods in Biomechanics and Biomedical Engineering. 1: 233-245. PMID 11264806 DOI: 10.1080/01495739808936704  0.718
1998 Jacobs CR, Yellowley CE, Davis BR, Zhou Z, Cimbala JM, Donahue HJ. Differential effect of steady versus oscillating flow on bone cells Journal of Biomechanics. 31: 969-976. PMID 9880053 DOI: 10.1016/S0021-9290(98)00114-6  0.408
1998 Eckstein F, Jacobs CR, Merz BR. Mechanobiological adaptation of subchondral bone as a function of joint incongruity and loading. Medical Engineering & Physics. 19: 720-8. PMID 9450256 DOI: 10.1016/S1350-4533(97)00031-3  0.458
1998 Jacobs CR, Davis BR, Naidu SH, Pellegrini VD, Case KL. Comparison of the fatigue lifetimes of simplex P and osteobond bone cement American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 39: 353-354.  0.318
1997 Jacobs CR, Eckstein F. Computer simulation of subchondral bone adaptation to mechanical loading in an incongruous joint Anatomical Record. 249: 317-326. PMID 9372165 DOI: 10.1002/(Sici)1097-0185(199711)249:3<317::Aid-Ar2>3.0.Co;2-R  0.529
1997 Yellowley CE, Jacobs CR, Li Z, Zhou Z, Donahue HJ. Effects of fluid flow on intracellular calcium in bovine articular chondrocytes American Journal of Physiology - Cell Physiology. 273. PMID 9252439 DOI: 10.1152/Ajpcell.1997.273.1.C30  0.314
1997 Jacobs CR, Simo JC, Beaupré GS, Carter DR. Adaptive bone remodeling incorporating simultaneous density and anisotropy considerations. Journal of Biomechanics. 30: 603-13. PMID 9165394 DOI: 10.1016/S0021-9290(96)00189-3  0.637
1997 Fischer KJ, Jacobs CR, Levenston ME, Carter DR. Observations of convergence and uniqueness of node-based bone remodeling simulations Annals of Biomedical Engineering. 25: 261-268. PMID 9084831 DOI: 10.1007/Bf02648040  0.727
1996 Fischer KJ, Jacobs CR, Levenston ME, Carter DR. Different loads can produce similar bone density distributions Bone. 19: 127-135. PMID 8853856 DOI: 10.1016/8756-3282(96)00140-8  0.744
1995 Jacobs CR, Levenston ME, Beaupré GS, Simo JC, Carter DR. Numerical instabilities in bone remodeling simulations: the advantages of a node-based finite element approach. Journal of Biomechanics. 28: 449-59. PMID 7738054 DOI: 10.1016/0021-9290(94)00087-K  0.732
1995 Fischer KJ, Jacobs CR, Carter DR. Computational method for determination of bone and joint loads using bone density distributions Journal of Biomechanics. 28: 1127-1135. PMID 7559684 DOI: 10.1016/0021-9290(94)00182-4  0.658
1994 Levenston ME, Beaupré GS, Jacobs CR, Carter DR. The role of loading memory in bone adaptation simulations Bone. 15: 177-186. PMID 8086235 DOI: 10.1016/8756-3282(94)90705-6  0.734
Low-probability matches (unlikely to be authored by this person)
2001 Buhl KM, Jacobs CR, Turner RT, Evans GL, Farrell PA, Donahue HJ. Aged bone displays an increased responsiveness to low-intensity resistance exercise Journal of Applied Physiology. 90: 1359-1364. PMID 11247935 DOI: 10.1152/Jappl.2001.90.4.1359  0.298
2008 Anderson CT, Castillo AB, Brugmann SA, Helms JA, Jacobs CR, Stearns T. Primary cilia: cellular sensors for the skeleton. Anatomical Record (Hoboken, N.J. : 2007). 291: 1074-8. PMID 18727074 DOI: 10.1002/Ar.20754  0.293
2003 Saunders MM, Schwentker EP, Kay DB, Bennett G, Jacobs CR, Verstraete MC, Njus GO. Finite element analysis as a tool for parametric prosthetic foot design and evaluation. Technique development in the solid ankle cushioned heel (SACH) foot. Computer Methods in Biomechanics and Biomedical Engineering. 6: 75-87. PMID 12623440 DOI: 10.1080/1025584021000048974  0.291
2003 Alford AI, Yellowley CE, Jacobs CR, Donahue HJ. Increases in Cytosolic Calcium, but not Fluid Flow, Affect Aggrecan mRNA Levels in Articular Chondrocytes Journal of Cellular Biochemistry. 90: 938-944. PMID 14624453 DOI: 10.1002/Jcb.10715  0.285
1999 Segal LS, Schneider DJ, Berlin JM, Bruno A, Davis BR, Jacobs CR. The contribution of the ossific nucleus to the structural stiffness of the capital femoral epiphysis: A porcine model for DDH Journal of Pediatric Orthopaedics. 19: 433-437. PMID 10412989 DOI: 10.1097/00004694-199907000-00003  0.283
2009 Mishra A, Tummala P, King A, Lee B, Kraus M, Tse V, Jacobs CR. Buffered platelet-rich plasma enhances mesenchymal stem cell proliferation and chondrogenic differentiation. Tissue Engineering. Part C, Methods. 15: 431-5. PMID 19216642 DOI: 10.1089/Ten.Tec.2008.0534  0.279
1998 Fedok FG, Van Kooten DW, DeJoseph LM, McGinn JD, Sobota B, Levin RJ, Jacobs CR. Plating techniques and plate orientation in repair of mandibular angle fractures: An in vitro study Laryngoscope. 108: 1218-1224. PMID 9707247 DOI: 10.1097/00005537-199808000-00022  0.278
2009 Sittichokechaiwut A, Jacobs CR, Reilly GC. Mechanical responses of bone tissue formation in 3D engineered constructs via primary cilia European Cells and Materials. 18: 16.  0.276
2012 Espinha LC, Hoey DA, Jacobs CR. OSCILLATORY FLUID FLOW INFLUENCES THE NUMBER OF MICROTUBULES ATTACHED TO THE BASE OF PRIMARY CILIA Journal of Biomechanics. 45: S446. DOI: 10.1016/S0021-9290(12)70447-5  0.274
1998 Buhl KM, Jacobs CR, Donahue HJ. Comprehensive investigation of skeletal dynamics in the aging rat Bioengineering, Proceedings of the Northeast Conference. 58-60.  0.272
2015 Chen JC, Chua M, Bellon RB, Jacobs CR. Epigenetic changes during mechanically induced osteogenic lineage commitment. Journal of Biomechanical Engineering. 137: 020902. PMID 25581684 DOI: 10.1115/1.4029551  0.269
2008 Kwon RY, Lew AJ, Jacobs CR. A microstructurally informed model for the mechanical response of three-dimensional actin networks. Computer Methods in Biomechanics and Biomedical Engineering. 11: 407-18. PMID 18568835 DOI: 10.1080/10255840801888686  0.269
2004 Haut Donahue TL, Hull ML, Rashid MM, Jacobs CR. The sensitivity of tibiofemoral contact pressure to the size and shape of the lateral and medial menisci. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 22: 807-14. PMID 15183438 DOI: 10.1016/J.Orthres.2003.12.010  0.261
2001 Moulton MJR, Parentis MA, Kelly MJ, Jacobs C, Naidu SH, Pellegrini VD. Influence of metacarpophalangeal joint position on basal joint-loading in the thumb. Journal of Bone and Joint Surgery, American Volume. 83: 709-716. PMID 11379740 DOI: 10.2106/00004623-200105000-00009  0.258
2021 Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR, Knight MM. Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype. Cancers. 13. PMID 34200761 DOI: 10.3390/cancers13122906  0.257
2006 Kwon RY, Jacobs CR. Viscoelasticity of bone cells exposed to fluid flow McB Molecular and Cellular Biomechanics. 3: 209.  0.256
2000 Donahue TH, Rashid MM, Hull ML, Jacobs CR. Finite element model of the human knee joint to study tibio-femoral contact mechanics American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 48: 155-156.  0.255
2000 Jacobs CR, Yellowley CE, Nelson DV, Donahue HJ. Analysis of Time-Varying Biological Data Using Rainflow Cycle Counting. Computer Methods in Biomechanics and Biomedical Engineering. 3: 31-40. PMID 11264837 DOI: 10.1080/10255840008915252  0.252
2017 Erdemir A, Hunter PJ, Holzapfel GA, Loew LM, Middleton J, Jacobs CR, Nithiarasu P, Lohner R, Wei G, Winkelstein BA, Barocas VH, Guilak F, Ku J, Hicks JL, Delp S, et al. Perspectives on Sharing Models and Related Resources in Computational Biomechanics Research. Journal of Biomechanical Engineering. PMID 29247253 DOI: 10.1115/1.4038768  0.252
2018 Moore ER, Ryu HS, Zhu YX, Jacobs CR. Adenylyl cyclases and TRPV4 mediate Ca/cAMP dynamics to enhance fluid flow-induced osteogenesis in osteocytes. Journal of Molecular Biochemistry. 7: 48-59. PMID 31123666  0.25
2004 Edlich M, Yellowley CE, Jacobs CR, Donahue HJ. Cycle number and waveform of fluid flow affect bovine articular chondrocytes. Biorheology. 41: 315-22. PMID 15299264  0.243
1999 Pellegrini VD, Schneider DJ, Deol GS, Jacobs C, Lesh ML. Paper #40 The consequences of anterior femoral notching in total knee arthroplasty - a biomechanical study Journal of Arthroplasty. 14: 256-257. DOI: 10.1016/S0883-5403(99)90174-2  0.239
2003 Donahue TL, Rosenberg G, Jacobs CR, Weiss WJ. Finite element analysis of stresses developed in blood sacs of a pusherplate blood pump. Computer Methods in Biomechanics and Biomedical Engineering. 6: 7-15. PMID 12623433 DOI: 10.1080/1025584031000078943  0.238
2004 Guo TZ, Offley SC, Boyd EA, Jacobs CR, Kingery WS. Substance P signaling contributes to the vascular and nociceptive abnormalities observed in a tibial fracture rat model of complex regional pain syndrome type I Pain. 108: 95-107. PMID 15109512 DOI: 10.1016/J.Pain.2003.12.010  0.237
2012 Brown G, Butler PJ, Chang DW, Chien S, Clegg RM, Dewey CF, Dong C, Guo XE, Helmke BP, Hess H, Jacobs CR, Kaunas RR, Kumar S, Lu HH, Mathur AB, et al. Cellular and Molecular Bioengineering: A Tipping Point. Cellular and Molecular Bioengineering. 5: 239-253. PMID 23264805 DOI: 10.1007/S12195-012-0246-7  0.233
2006 Litzenberger JB, Tummala P, Jacobs CR. Integrin signaling and the response of osteocytes to oscillatory fluid flow McB Molecular and Cellular Biomechanics. 3: 219-220.  0.229
1999 Black KP, Schneider DJ, Yu JR, Jacobs CR. Biomechanics of the Bankart repair: The relationship between glenohumeral translation and labral fixation site American Journal of Sports Medicine. 27: 339-344. PMID 10352770 DOI: 10.1177/03635465990270031201  0.226
2018 Moore ER, Zhu YX, Ryu HS, Jacobs CR. Correction to: Periosteal progenitors contribute to load-induced bone formation in adult mice and require primary cilia to sense mechanical stimulation. Stem Cell Research & Therapy. 9: 229. PMID 30153854 DOI: 10.1186/s13287-018-0975-1  0.22
2001 Jacobs CR, Poncet S. Large scale finite element modeling of trabecular bone tissue: An error estimate using PMMA replicas with realistic microarchitecture American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 50: 231-232.  0.218
2001 You J, Saunders MM, Yellowley CE, Donahue HJ, Jacobs CR. Oscillatory flow-induced prostaglandin E2 release involves protein kinase a and cyclooxygenase-2 in MC3T3-E1 osteoblasts American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 50: 163-164.  0.216
2000 Jacobs C. Skeletal Tissue Mechanics R. Bruce Martin, David B. Burr and Neil A. Sharkey (Eds.); Springer, New York, 1998, 392 pages, ISBN: 0-387-98474-7 Journal of Biomechanics. 33: 1339. DOI: 10.1016/S0021-9290(00)00029-4  0.214
1999 Barr JD, Hoffman EJ, Davis BR, Edgar KA, Jacobs CR. Microcatheter adhesion of cyanoacrylates: comparison of normal butyl cyanoacrylate to 2-hexyl cyanoacrylate. Journal of Vascular and Interventional Radiology : Jvir. 10: 165-8. PMID 10082103 DOI: 10.1016/S1051-0443(99)70459-8  0.211
2010 Tummala P, Arnsdorf EJ, Jacobs CR. The role of primary cilia in mesenchymal stem cell differentiation: A pivotal switch in guiding lineage commitment Cellular and Molecular Bioengineering. 3: 207-212. DOI: 10.1007/s12195-010-0127-x  0.195
2010 Herzog FA, Geraedts J, Hoey D, Jacobs CR. A mathematical approach to study the bending behavior of the primary cilium Proceedings of the 2010 Ieee 36th Annual Northeast Bioengineering Conference, Nebec 2010. DOI: 10.1109/NEBC.2010.5458157  0.176
2023 Verbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR, Knight MM. A Novel Primary Cilium-Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2305842. PMID 37967351 DOI: 10.1002/advs.202305842  0.172
1999 Edlich MJ, Jacobs CR, Yellowley CE, Donahue HJ. Differential effect of steady and oscillating flow on intracellular calcium dynamics and the influence of FBS on bovine articular chondrocytes American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 42: 255-256.  0.17
2010 Jacobs CR, Guilak F. In Memoriam: Charles H. Turner Journal of Biomechanics. 43: 2868. DOI: 10.1016/J.Jbiomech.2010.09.024  0.17
2025 Westcott GP, Emont MP, Gulko A, Zhou Z, Kim C, Varma G, Tsai LL, O'Donnell E, Loureiro ZY, Liang W, Jacobs C, Tsai LT, Padera TP, Singhal D, Rosen ED. Single-nuclear transcriptomics of lymphedema-associated adipose reveals a pro-lymphangiogenic stromal cell population. Biorxiv : the Preprint Server For Biology. PMID 40027673 DOI: 10.1101/2025.02.18.638907  0.166
2003 Batra NN, Li YJ, Yellowley CE, Park K, Jacobs CR. EFFECT OF SHORT TERM RECOVERY PERIODS ON FLUID SHEAR INDUCED CALCIUM OSCILLATIONS IN OSTEOBLASTIC CELLS Medicine & Science in Sports & Exercise. 35: S4. DOI: 10.1097/00005768-200305001-00018  0.166
2006 Temiyasathit S, Tang WJ, Anderson CT, Stearns TP, Jacobs CR. Primary cilia as sensors of mechanical loading McB Molecular and Cellular Biomechanics. 3: 215-216.  0.162
2003 You LD, Li YJ, Batra NN, Jacobs CR. PROLIFERATON RATE REGULATION BY OSCILLATORY FLUID FLOW IN STEM CELLS Medicine & Science in Sports & Exercise. 35: S4. DOI: 10.1097/00005768-200305001-00017  0.154
2011 Middleton J, Jacobs C. In Memoriam Professor Rik Huiskes (1944–2010) Computer Methods in Biomechanics and Biomedical Engineering. 14: 399-399. DOI: 10.1080/10255842.2011.565665  0.153
2005 Malone AM, Cheng DK, Rodriguez JJ, Tummala P, Jacobs CR. The effects of oscillatory fluid flow on mapk phosphorylation in osteoblasts Proceedings of the 2005 Summer Bioengineering Conference. 2005: 1256-1257.  0.152
2005 Shivaram GM, Kim CH, Batra NN, Jacobs CR. Novel early response genes in MC3T3-E1 pre-osteoblasts exposed to oscillatory fluid flow Proceedings of the 2005 Summer Bioengineering Conference. 2005: 165-166.  0.152
2009 Temiyasathit S, Kwon RY, Tummala P, Quah CC, Jacobs CR. Adenylyl cyclase 6 mediates primary cilia-dependent changes in cyclic adenosine monophosphate in response to dynamic fluid flow Proceedings of the Asme Summer Bioengineering Conference 2009, Sbc2009. 1027-1028. DOI: 10.1115/SBC2009-206200  0.151
2011 Jacobs CR, Kelly DJ. Cell mechanics: The role of simulation Computational Methods in Applied Sciences. 20: 1-14. DOI: 10.1007/978-94-007-1254-6_1  0.145
2018 Roh HC, Tsai LTY, Shao M, Tenen D, Shen Y, Kumari M, Lyubetskaya A, Jacobs C, Dawes B, Gupta RK, Rosen ED. Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity. Cell Metabolism. PMID 29657031 DOI: 10.1016/J.Cmet.2018.03.005  0.125
2021 Li J, Li E, Czepielewski RS, Chi J, Guo X, Han YH, Wang D, Wang L, Hu B, Dawes B, Jacobs C, Tenen D, Lin SJ, Lee B, Morris D, et al. Neurotensin is an anti-thermogenic peptide produced by lymphatic endothelial cells. Cell Metabolism. PMID 34038712 DOI: 10.1016/j.cmet.2021.04.019  0.124
2011 Herzog FA, Jacobs CR. Effects of mechanical stress on cells Comprehensive Biomaterials. 5: 73-80.  0.122
2025 Claudio Medina Y, Farres H, Arroyo HM, Polania Sandoval C, Jacobs C, Vernon CE, Vandenberg J, Erben Y. Higher All-Cause but Not Aortic-Related Mortality for Women After Abdominal Aortic Aneurysm Repair. The Journal of Surgical Research. 311: 172-180. PMID 40435879 DOI: 10.1016/j.jss.2025.04.030  0.12
2013 Middleton J, Jacobs C. In Memoriam Computer Methods in Biomechanics and Biomedical Engineering. 16: 689-690. DOI: 10.1080/10255842.2013.821300  0.12
2022 Emont MP, Jacobs C, Essene AL, Pant D, Tenen D, Colleluori G, Di Vincenzo A, Jørgensen AM, Dashti H, Stefek A, McGonagle E, Strobel S, Laber S, Agrawal S, Westcott GP, et al. A single-cell atlas of human and mouse white adipose tissue. Nature. PMID 35296864 DOI: 10.1038/s41586-022-04518-2  0.119
2021 Westcott GP, Emont MP, Li J, Jacobs C, Tsai L, Rosen ED. Mesothelial cells are not a source of adipocytes in mice. Cell Reports. 36: 109388. PMID 34260927 DOI: 10.1016/j.celrep.2021.109388  0.118
2006 Malone AMD, Anderson CT, Tummala P, Stearns T, Jacobs CR. Primary cilia mediate PGE2 release in MC3T3-E1 osteoblasts McB Molecular and Cellular Biomechanics. 3: 207-208.  0.113
2001 Blankenhorn BD, Pellegrini VD, Jacobs CR. The influence of coronal malalignment on the contact area of total knee prostheses American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 50: 747-748.  0.11
2022 Pita-Juarez Y, Karagkouni D, Kalavros N, Melms JC, Niezen S, Delorey TM, Essene AL, Brook OR, Pant D, Skelton-Badlani D, Naderi P, Huang P, Pan L, Hether T, Andrews TS, ... ... Jacobs C, et al. A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients. Biorxiv : the Preprint Server For Biology. PMID 36324805 DOI: 10.1101/2022.10.27.514070  0.101
1986 Gurtler RA, Jacobs RR, Jacobs CR. Biomechanical evaluation of the Ender's pins, the Harris nail, and the dynamic hip screw for the unstable intertrochanteric fracture Clinical Orthopaedics and Related Research. 109-112. PMID 3708962  0.1
2023 Ciampa EJ, Flahardy P, Srinivasan H, Jacobs C, Tsai L, Karumanchi SA, Parikh SM. Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor. Elife. 12. PMID 37610425 DOI: 10.7554/eLife.85597  0.095
2025 Emont MP, Essene AL, Gulko A, Bozadjieva-Kramer N, Jacobs C, Nagesh S, Seeley RJ, Tsai LT, Rosen ED. Semaglutide and bariatric surgery induce distinct changes in the composition of mouse white adipose tissue. Molecular Metabolism. 95: 102126. PMID 40139440 DOI: 10.1016/j.molmet.2025.102126  0.095
2001 Haut Donahue TL, Hull ML, Rashid MM, Jacobs CR. The sensitivity of tibio-femoral contact to parameters describing the geometry of the lateral and medial menisci American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 50: 227-228.  0.092
2024 Holman CD, Sakers AP, Calhoun RP, Cheng L, Fein EC, Jacobs C, Tsai L, Rosen ED, Seale P. Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming. Elife. 12. PMID 38775132 DOI: 10.7554/eLife.87756  0.081
2017 Jacobs C, Lambourne L, Xia Y, Segrè D. Upon Accounting for the Impact of Isoenzyme Loss, Gene Deletion Costs Anticorrelate with Their Evolutionary Rates. Plos One. 12: e0170164. PMID 28107392 DOI: 10.1371/Journal.Pone.0170164  0.08
1987 Jacobs R, Jauch E, Jacobs C, Montesano P. Sacral and lumbar pedicle fixation: A biomechanical evaluation Journal of Biomechanics. 20: 905. DOI: 10.1016/0021-9290(87)90203-X  0.079
2023 Holman CD, Sakers AP, Calhoun RP, Cheng L, Fein EC, Jacobs C, Tsai L, Rosen ED, Seale P. Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming. Biorxiv : the Preprint Server For Biology. PMID 36993336 DOI: 10.1101/2023.03.20.533514  0.079
2007 Jacobs CR. Primary cilia Journal of Musculoskeletal &Amp; Neuronal Interactions. 7: 297-298. PMID 18094479  0.071
2017 Mendoza A, Astapova I, Shimizu H, Gallop MR, Al-Sowaimel L, MacGowan SMD, Bergmann T, Berg AH, Tenen DE, Jacobs C, Lyubetskaya A, Tsai L, Hollenberg AN. NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor. Proceedings of the National Academy of Sciences of the United States of America. PMID 28923959 DOI: 10.1073/Pnas.1706917114  0.07
2024 Heyward FD, Liu N, Jacobs C, Machado NLS, Ivison R, Uner A, Srinivasan H, Patel SJ, Gulko A, Sermersheim T, Tsai L, Rosen ED. AgRP neuron cis-regulatory analysis across hunger states reveals that IRF3 mediates leptin's acute effects. Nature Communications. 15: 4646. PMID 38821928 DOI: 10.1038/s41467-024-48885-y  0.07
2023 Emont MP, Jacobs C, Essene AL, Pant D, Tenen D, Colleluori G, Di Vincenzo A, Jørgensen AM, Dashti H, Stefek A, McGonagle E, Strobel S, Laber S, Agrawal S, Westcott GP, et al. Author Correction: A single-cell atlas of human and mouse white adipose tissue. Nature. PMID 37495702 DOI: 10.1038/s41586-023-06445-2  0.067
2021 Jacobs CR, Scali ST, Khan T, Cadavid F, Staton KM, Feezor RJ, Back MR, Upchruch GR, Huber TS. EVAR Conversion is an Increasingly Common Indication for Open AAA Repair. Journal of Vascular Surgery. PMID 34314833 DOI: 10.1016/j.jvs.2021.07.121  0.06
2021 Jacobs CR, Scali ST, Khan T, Cadavid F, Staton KM, Feezor RJ, Back MR, Upchruch GR, Huber TS. EVAR Conversion is an Increasingly Common Indication for Open AAA Repair. Journal of Vascular Surgery. PMID 34314833 DOI: 10.1016/j.jvs.2021.07.121  0.06
2021 Yan S, Kumari M, Xiao H, Jacobs C, Kochumon S, Jedrychowski M, Chouchani E, Ahmad R, Rosen ED. IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis. The Journal of Clinical Investigation. PMID 33571167 DOI: 10.1172/JCI144888  0.056
1999 Jacobs CR. Large-scale finite element solutions on workstation class computers American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed. 42: 405-406.  0.056
2020 Roh HC, Kumari M, Taleb S, Tenen D, Jacobs C, Lyubetskaya A, Tsai LT, Rosen ED. Adipocytes Fail to Maintain Cellular Identity During Obesity Due to Reduced PPARγ Activity and Elevated TGFβ-SMAD Signaling. Molecular Metabolism. 101086. PMID 32992037 DOI: 10.1016/j.molmet.2020.101086  0.054
2005 Kwon RY, Jacobs CR, Lew AJ. Computational modeling of actin networks Proceedings of the 2005 Summer Bioengineering Conference. 2005: 1260-1261.  0.054
2020 Hall JA, Ramachandran D, Roh HC, DiSpirito JR, Belchior T, Zushin PH, Palmer C, Hong S, Mina AI, Liu B, Deng Z, Aryal P, Jacobs C, Tenen D, Brown CW, et al. Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3. Cell Metabolism. PMID 32941798 DOI: 10.1016/J.Cmet.2020.08.016  0.052
2012 Jacobs C, Segrè D. Organization principles in genetic interaction networks. Advances in Experimental Medicine and Biology. 751: 53-78. PMID 22821453 DOI: 10.1007/978-1-4614-3567-9_3  0.047
2025 Pita-Juarez Y, Karagkouni D, Kalavros N, Melms JC, Niezen S, Delorey TM, Essene AL, Brook OR, Pant D, Skelton-Badlani D, Naderi P, Huang P, Pan L, Hether T, Andrews TS, ... ... Jacobs C, et al. A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients. Genome Biology. 26: 56. PMID 40087773 DOI: 10.1186/s13059-025-03499-5  0.047
2013 Brown CH, Mohr DC, Gallo CG, Mader C, Palinkas L, Wingood G, Prado G, Kellam SG, Pantin H, Poduska J, Gibbons R, McManus J, Ogihara M, Valente T, Wulczyn F, ... ... Jacobs C, et al. A computational future for preventing HIV in minority communities: how advanced technology can improve implementation of effective programs. Journal of Acquired Immune Deficiency Syndromes (1999). 63: S72-84. PMID 23673892 DOI: 10.1097/Qai.0B013E31829372Bd  0.046
2025 Polania-Sandoval C, Meschia JF, Huang J, Esquetini-Vernon C, Fuentes-Perez A, Jeevaratnam S, Barrett KM, Fox WC, Miller DA, Chen X, Jacobs C, Beegle RD, Tawk R, Sandhu SJS, Farres H, et al. Comparison of Restenosis and Reintervention Rates in Closed Cell Stents Compared to Open Cell Stents After Carotid Artery Stenting. Journal of Vascular Surgery. PMID 40180162 DOI: 10.1016/j.jvs.2025.03.199  0.046
2025 Alsabbagh Y, Lanka SP, Martinez PM, Jena A, Erben Y, Jacobs C, Tallarita T, Shuja F, Davila V, Sanghavi DK, Farres H. Impact of Estimated Plasma Volume Status on Postoperative Outcomes in Patients Undergoing Open Abdominal Aortic Aneurysm Repair. Journal of Vascular Surgery. PMID 40239851 DOI: 10.1016/j.jvs.2025.04.012  0.044
2022 Jacobs CR, Scali ST, Filiberto A, Anderson E, Fazzone B, Back MR, Cooper M, Upchurch GR, Huber TS. Psoas Muscle Area as a Prognostic Factor for Survival in Patients Undergoing EVAR Conversion. Annals of Vascular Surgery. PMID 36058454 DOI: 10.1016/j.avsg.2022.08.001  0.042
2016 Gordon D, Jacobs C, Beasley A, Peck A, Gaume R, Charlot P, Fey A, Ma C, Titov O, Boboltz D. Second Epoch VLBA Calibrator Survey Observations - VCS-II. The Astronomical Journal. 151. PMID 29937549 DOI: 10.3847/0004-6256/151/6/154  0.041
2019 Jacobs C, Read TE. "Peek port": avoiding conversion during laparoscopic colectomy-an update. Surgical Endoscopy. 34: 3944-3948. PMID 31586252 DOI: 10.1007/s00464-019-07165-3  0.04
2023 Mirzaie AA, Cooper MA, Weaver ML, Jacobs CR, Cox ML, Berceli SA, Scali ST, Back MR, Huber TS, Upchurch GR, Shah SK. NIH Funding Among Vascular Surgeons is Rare. Journal of Vascular Surgery. PMID 37327950 DOI: 10.1016/j.jvs.2023.05.052  0.038
2012 Stover HJ, Thorn RG, Bowles JM, Bernards MA, Jacobs CR. Arbuscular mycorrhizal fungi and vascular plant species abundance and community structure in tallgrass prairies with varying agricultural disturbance histories Applied Soil Ecology. 60: 61-70. DOI: 10.1016/J.Apsoil.2012.02.016  0.038
2010 Chandani S, Jacobs C, Loechler EL. Architecture of y-family DNA polymerases relevant to translesion DNA synthesis as revealed in structural and molecular modeling studies. Journal of Nucleic Acids. 2010. PMID 20936174 DOI: 10.4061/2010/784081  0.036
2021 Mendoza A, Tang C, Choi J, Acuña M, Logan M, Martin AG, Al-Sowaimel L, Desai BN, Tenen DE, Jacobs C, Lyubetskaya A, Fu Y, Liu H, Tsai L, Cohen DE, et al. Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP. Science Signaling. 14: eabh3839. PMID 34784250 DOI: 10.1126/scisignal.abh3839  0.036
2011 Dreyfuss JM, Jacobs C, Gindin Y, Benson G, Staples GO, Zaia J. Targeted analysis of glycomics liquid chromatography/mass spectrometry data. Analytical and Bioanalytical Chemistry. 399: 727-35. PMID 20953780 DOI: 10.1007/S00216-010-4235-1  0.036
2024 Jacobs CR, Scali ST, Jacobs BN, Filiberto AC, Anderson EM, Fazzone B, Back MR, Upchurch GR, Giles KA, Huber TS. Comparative Outcomes of Open Mesenteric Bypass after a Failed Endovascular or Open Mesenteric Revascularization for Chronic Mesenteric Ischemia. Journal of Vascular Surgery. PMID 38552885 DOI: 10.1016/j.jvs.2024.03.028  0.035
2025 Johnson H, Huang D, Liu V, Ammouri MA, Jacobs C, El-Osta A. Impact of Digital Engagement on Weight Loss Outcomes in Obesity Management Among Individuals Using GLP-1 and Dual GLP-1/GIP Receptor Agonist Therapy: Retrospective Cohort Service Evaluation Study. Journal of Medical Internet Research. 27: e69466. PMID 40164173 DOI: 10.2196/69466  0.029
2020 Jacobs CR, Fatima J, Scali ST, Hodges ZH, Back MR, Arnaoutakis DJ, Shah SK, Huber TS. Surgical Treatment of True Superior Mesenteric Artery Aneurysms. Annals of Vascular Surgery. PMID 32941966 DOI: 10.1016/j.avsg.2020.08.142  0.024
2022 Jacobs CR, Scali ST, Staton KM, Neal D, Cooper MA, Robinson ST, Jacobs BN, Shah SK, Shahid Z, Back MR, Upchurch GR, Huber TS. Outcomes of EVAR Conversion in Octogenarians Treated at a High-Volume Aorta Center. Journal of Vascular Surgery. PMID 35667603 DOI: 10.1016/j.jvs.2022.04.033  0.024
2023 Filiberto AC, Adiyeke E, Ozrazgat-Baslanti T, Jacobs CR, Fazzone B, Bihorac A, Upchurch GR, Cooper M. Persistent Acute Kidney Injury is Associated with Poor Outcomes and Increased Hospital Cost in Vascular Surgery. Annals of Vascular Surgery. PMID 37423327 DOI: 10.1016/j.avsg.2023.06.023  0.024
2025 Esquetini-Vernon C, Meschia JF, Huang J, Sandoval CP, Rajab M, Barrett KM, Fox WC, Miller DA, Tawk RG, Pomales Diaz GC, Oyefeso E, Benchaaboune R, Cruz-Gonzalez G, Hartwell JR, Jeevaratnam S, ... ... Jacobs C, et al. Higher Rate of Reinterventions After Transfemoral Carotid Artery Stenting in Symptomatic Patients: A Retrospective Stroke Center's Cohort Study between 2015-2024. Annals of Vascular Surgery. PMID 39855389 DOI: 10.1016/j.avsg.2024.12.074  0.023
2024 Krebs JR, Filiberto AC, Fazzone B, Jacobs CR, Anderson EM, Shahid Z, Back M, Upchurch GR, Cooper M. Outcomes of Patients with Acute Type B Aortic Dissection and High-Risk Features. Annals of Vascular Surgery. PMID 38574807 DOI: 10.1016/j.avsg.2024.01.012  0.022
2024 Jacobs CR, Lanka S, Erben Y, Clendenon J, Alsabbagh Y, Taner CB, Mao S, Perry D, Farres H. Novel Modified Iliac Artery Stent Graft with Side Branch Extension Facilitating Kidney Transplant in Severe Aortoiliac Occlusive Disease. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 39551264 DOI: 10.1016/j.ajt.2024.11.015  0.022
2019 Jacobs CR, Crawford JD, Fatima J. Hybrid management approach for superior mesenteric artery and branch aneurysms. Journal of Vascular Surgery Cases and Innovative Techniques. 5: 521-524. PMID 31909308 DOI: 10.1016/j.jvscit.2019.10.002  0.019
2025 Arroyo HM, Farres H, Medina YC, Sandoval CP, Vernon CE, Jacobs C, Vandenberg J, Erben Y. Chronic Kidney Disease is a Stronger Predictor for Mortality than Charlson Comorbidity Index After Abdominal Aortic Aneurysm Repair. Annals of Vascular Surgery. PMID 40233895 DOI: 10.1016/j.avsg.2025.03.029  0.017
2023 Schubbe D, Yen RW, Leavitt H, Forcino RC, Jacobs C, Friedman EB, McEvoy M, Rosenkranz KM, Rojas KE, Bradley A, Crayton E, Jackson S, Mitchell M, O'Malley AJ, Politi M, et al. Implementing shared decision making for early-stage breast cancer treatment using a coproduction learning collaborative: the SHAIR Collaborative protocol. Implementation Science Communications. 4: 79. PMID 37452387 DOI: 10.1186/s43058-023-00453-z  0.017
2023 Filiberto AC, Miao S, Ren Y, Ozrazgat-Baslanti T, Hensley SE, Jacobs CR, Weaver ML, Upchurch GR, Bihorac A, Cooper M. Bilateral renal artery stenosis impacts postoperative complications after major vascular surgery. Surgery Open Science. 14: 17-21. PMID 37409074 DOI: 10.1016/j.sopen.2023.06.001  0.017
2025 Polania-Sandoval C, Farres H, Esquetini-Vernon C, Vandenberg J, Morales Arroyo HA, Mahajan B, Medina YC, Jacobs C, Erben Y. Height Index and Diameter as Predictors of Outcomes in Males With Abdominal Aortic Aneurysms. The Journal of Surgical Research. 310: 22-29. PMID 40267798 DOI: 10.1016/j.jss.2025.03.053  0.017
2025 Polania-Sandoval C, Meschia JF, Huang J, Esquetini-Vernon C, Barrett KM, Fox WC, Miller DA, Chen X, Jacobs C, Huynh T, Beegle RD, Tawk R, Sandhu SJS, Farres H, Erben Y. Urgent Carotid Artery Revascularization Fraught with Higher Rates of Neurovascular Events In Symptomatic Carotid Artery Stenosis. Annals of Vascular Surgery. PMID 40320211 DOI: 10.1016/j.avsg.2025.04.124  0.015
2011 Guilak F, Jacobs CR. The H-index: Use and overuse Journal of Biomechanics. 44: 208-209. DOI: 10.1016/J.Jbiomech.2010.11.006  0.015
2024 Chen X, Meschia JF, Huang J, Polania-Sandoval C, Esquetini-Vernon C, Rajab M, Barrett KM, Fox WC, Miller DA, Tawk R, Jeevaratnam S, Jacobs C, Beegle RD, Sandhu SJS, Farres H, et al. Intraplaque Hemorrhage and Plaque Ulceration Are More Likely in Patients with Symptomatic Mild-to-Moderate Carotid Artery Stenosis than in Symptomatic and Asymptomatic High-Grade Stenosis: A Retrospective Cohort Study. Annals of Vascular Surgery. PMID 39674272 DOI: 10.1016/j.avsg.2024.12.004  0.01
2019 Jacobs C, Loftus TJ, Manning EW, Moore FA, Brakenridge SC. Cardiac Pseudoaneurysm Following Non-Operative Management After Penetrating Thoracoabdominal Trauma and Pericardial Window. The Journal of Trauma and Acute Care Surgery. PMID 30629012 DOI: 10.1097/TA.0000000000002189  0.01
2011 Grande DA, Shah NV, Catanzano A, Nelson FRT, Hoey D, Jacobs C. On the Horizon From the ORS. The Journal of the American Academy of Orthopaedic Surgeons. 19: 59-62. PMID 29329125  0.01
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