☰

Jun-Lin Guan - Publications

Affiliations: 
1991-2006 Cornell University, Ithaca, NY, United States 
 2006-2014 Cell and Developmental Biology University of Michigan Medical School, Ann Arbor, MI, United States 
 2014- University of Cincinnati College of Medicine, Cincinnati, OH, United States 
Area:
Cell Biology, Biochemistry
Website:
https://med.uc.edu/cancerbiology/about/chair
Tree Info Similar researchers PubMed Report error

179 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Liu H, Su P, Li Y, Hoover A, Hu S, King SA, Zhao J, Guan JL, Chen SY, Zhao Y, Tan M, Wu X. VAMP2 controls murine epidermal differentiation and carcinogenesis by regulation of nucleophagy. Developmental Cell. PMID 38810653 DOI: 10.1016/j.devcel.2024.05.004  0.484
2024 Manupati K, Hao M, Haas M, Yeo SK, Guan JL. Role of NuMA1 in breast cancer stem cells with implications for combination therapy of PIM1 and autophagy inhibition in triple negative breast cancer. Research Square. PMID 38645153 DOI: 10.21203/rs.3.rs-3953289/v1  0.729
2024 Hao M, Lu P, Sotropa S, Manupati K, Yeo SK, Guan JL. In vivo CRISPR knockout screen identifies p47 as a suppressor of HER2+ breast cancer metastasis by regulating NEMO trafficking and autophagy flux. Cell Reports. 43: 113780. PMID 38363674 DOI: 10.1016/j.celrep.2024.113780  0.731
2023 Yeo SK, Haas M, Manupati K, Hao M, Yang F, Chen S, Guan JL. AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancer. Autophagy. 1-16. PMID 37733921 DOI: 10.1080/15548627.2023.2259775  0.74
2023 Yang F, Guan JL. Autophagy-dependent expression of osteopontin and its downstream Stat3 signaling contributes to lymphatic malformation progression to lymphangiosarcoma. Autophagy. 1-2. PMID 37170617 DOI: 10.1080/15548627.2023.2213527  0.335
2023 Yang F, Kalantari S, Ruan B, Sun S, Bian Z, Guan JL. Autophagy inhibition prevents lymphatic malformation progression to lymphangiosarcoma by decreasing osteopontin and Stat3 signaling. Nature Communications. 14: 978. PMID 36813768 DOI: 10.1038/s41467-023-36562-5  0.33
2022 Yi F, Cai C, Ruan B, Hao M, Yeo SK, Haas M, Yang F, Zhang X, Guan JL. Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region. Autophagy. 1-16. PMID 36394358 DOI: 10.1080/15548627.2022.2148432  0.71
2022 Holm TM, Yeo S, Turner KM, Guan JL. Targeting Autophagy in Thyroid Cancer: EMT, Apoptosis, and Cancer Stem Cells. Frontiers in Cell and Developmental Biology. 10: 821855. PMID 35846375 DOI: 10.3389/fcell.2022.821855  0.725
2022 Yang Y, Zhu Y, Zhou S, Tang P, Xu R, Zhang Y, Wei D, Wen J, Thorne RF, Zhang XD, Guan JL, Liu L, Wu M, Chen S. TRIM27 cooperates with STK38L to inhibit ULK1-mediated autophagy and promote tumorigenesis. The Embo Journal. e109777. PMID 35670107 DOI: 10.15252/embj.2021109777  0.319
2022 Manupati K, Paul R, Hao M, Haas M, Bian ZC, Holm TM, Guan JL, Yeo SK. Biglycan Promotes Cancer Stem Cell Properties, NFκB Signaling and Metastatic Potential in Breast Cancer Cells. Cancers. 14. PMID 35053617 DOI: 10.3390/cancers14020455  0.715
2021 Liu H, Wang C, Yi F, Yeo S, Haas M, Tang X, Guan JL. Non-canonical function of FIP200 is required for neural stem cell maintenance and differentiation by limiting TBK1 activation and p62 aggregate formation. Scientific Reports. 11: 23907. PMID 34903812 DOI: 10.1038/s41598-021-03404-7  0.718
2021 Holm TM, Bian ZC, Manupati K, Guan JL. Inhibition of autophagy mitigates cell migration and invasion in thyroid cancer. Surgery. PMID 34565609 DOI: 10.1016/j.surg.2021.08.024  0.319
2021 Turner KM, Yeo SK, Holm TM, Shaughnessy E, Guan JL. Heterogeneity Within Molecular Subtypes of Breast Cancer. American Journal of Physiology. Cell Physiology. PMID 34191627 DOI: 10.1152/ajpcell.00109.2021  0.709
2021 Wang C, Haas M, Yeo SK, Sebti S, Fernández ÁF, Zou Z, Levine B, Guan JL. Enhanced autophagy in knockin mice counteracts aging-related neural stem cell exhaustion and dysfunction. Autophagy. 1-14. PMID 34101533 DOI: 10.1080/15548627.2021.1936358  0.699
2021 Hao M, Yeo SK, Guan JL. Autophagy inhibition perturbs ERBB2 trafficking and abolishes tumorigenesis in ERBB2-driven breast cancer. Autophagy. 1-2. PMID 33757386 DOI: 10.1080/15548627.2021.1907168  0.727
2021 Wang C, Haas MA, Yeo SK, Paul R, Yang F, Vallabhapurapu S, Qi X, Plas DR, Guan JL. Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis. British Journal of Cancer. PMID 33723393 DOI: 10.1038/s41416-021-01294-0  0.734
2021 Yang Y, Leonard M, Luo Z, Yeo S, Bick G, Hao M, Cai C, Charif M, Wang J, Guan JL, Lower EE, Zhang X. Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer. Cell Reports. 34: 108822. PMID 33691110 DOI: 10.1016/j.celrep.2021.108822  0.735
2021 Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, ... Guan JL, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 1-382. PMID 33634751 DOI: 10.1080/15548627.2020.1797280  0.491
2021 Hao M, Yeo SK, Turner K, Harold A, Yang Y, Zhang X, Guan JL. Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles. Developmental Cell. PMID 33472043 DOI: 10.1016/j.devcel.2020.12.016  0.744
2020 Yeo SK, Zhu X, Okamoto T, Hao M, Wang C, Lu P, Lu LJ, Guan JL. Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer. Elife. 9. PMID 32840210 DOI: 10.7554/Elife.58810  0.74
2020 Xia H, Li S, Li X, Wang W, Bian Y, Wei S, Grove S, Wang W, Vatan L, Liu JR, McLean K, Rattan R, Munkarah AR, Guan JL, Kryczek I, et al. Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis. Jci Insight. PMID 32780724 DOI: 10.1172/Jci.Insight.141115  0.391
2020 Yeo SK, Guan JL. Regulation of immune checkpoint blockade efficacy in breast cancer by FIP200: A canonical-autophagy-independent function. Cell Stress. 4: 216-217. PMID 32743346 DOI: 10.15698/cst2020.08.229  0.728
2020 Yeo SK, Wang C, Guan JL. Role of FIP200 in inflammatory processes beyond its canonical autophagy function. Biochemical Society Transactions. PMID 32662824 DOI: 10.1042/Bst20191156  0.731
2020 Paul R, Luo M, Mo X, Lu J, Yeo SK, Guan JL. Correction to: FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors. Breast Cancer Research : Bcr. 22: 71. PMID 32600368 DOI: 10.1186/S13058-020-01310-W  0.722
2020 Okamoto T, Yeo SK, Hao M, Copley MR, Haas MA, Chen S, Guan JL. FIP200 suppresses immune checkpoint therapy responses in breast cancers by limiting AZI2/TBK1/IRF signaling independent of its canonical autophagy function. Cancer Research. PMID 32580962 DOI: 10.1158/0008-5472.Can-20-0519  0.748
2020 Paul R, Luo M, Mo X, Lu J, Yeo SK, Guan JL. FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors. Breast Cancer Research : Bcr. 22: 59. PMID 32493400 DOI: 10.1186/S13058-020-01298-3  0.741
2020 Yang F, Sun S, Wang C, Haas M, Yeo S, Guan JL. Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation. British Journal of Cancer. PMID 32336756 DOI: 10.1038/S41416-020-0839-1  0.71
2020 Qi S, Sun X, Choi HK, Yao J, Wang L, Wu G, He Y, Pan J, Guan JL, Liu F. FAK promotes early osteoprogenitor cell proliferation by enhancing mTORC1 signaling. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 32286710 DOI: 10.1002/Jbmr.4029  0.449
2020 Deng S, Essandoh K, Wang X, Li Y, Huang W, Chen J, Peng J, Jiang DS, Mu X, Wang C, Peng T, Guan JL, Wang Y, Jegga A, Huang K, et al. Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage. Redox Biology. 101453. PMID 32057709 DOI: 10.1016/J.Redox.2020.101453  0.301
2020 Wu HJ, Hao M, Yeo SK, Guan JL. FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication. Oncogene. PMID 31988451 DOI: 10.1038/S41388-020-1162-2  0.76
2020 Yeo SK, Zhu X, Okamoto T, Hao M, Wang C, Lu P, Lu LJ, Guan J. Author response: Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer Elife. DOI: 10.7554/Elife.58810.Sa2  0.361
2019 Wang C, Haas MA, Yang F, Yeo S, Okamoto T, Chen S, Wen J, Sarma P, Plas DR, Guan JL. Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells. Nature Metabolism. 1: 1127-1140. PMID 32577608 DOI: 10.1038/s42255-019-0137-5  0.727
2019 Zachari M, Gudmundsson SR, Li Z, Manifava M, Shah R, Smith M, Stronge J, Karanasios E, Piunti C, Kishi-Itakura C, Vihinen H, Jokitalo E, Guan JL, Buss F, Smith AM, et al. Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform. Developmental Cell. PMID 31353311 DOI: 10.1016/J.Devcel.2019.06.016  0.317
2019 Jeong K, Kim JH, Murphy JM, Park H, Kim SJ, Rodriguez Y, Kong H, Choi C, Guan JL, Taylor JM, Lincoln TM, Gerthoffer WT, Kim JS, Ahn EE, Schlaepfer DD, et al. Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-mediated Cyclin D1 Transcription. Circulation Research. PMID 31096851 DOI: 10.1161/Circresaha.118.314344  0.352
2019 Ho WY, Tai YK, Chang JC, Liang J, Tyan SH, Chen S, Guan JL, Zhou H, Shen HM, Koo E, Ling SC. The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy. Autophagy. PMID 30669939 DOI: 10.1080/15548627.2019.1569441  0.313
2019 Yang F, Wang C, Sun S, Haas M, Yeo S, Guan J. Abstract 4267: mTORC1-dependent tumors have innate vulnerability to autophagic cell death by HDAC inhibitors Cancer Research. 79: 4267-4267. DOI: 10.1158/1538-7445.Am2019-4267  0.427
2019 Yang F, Sun S, Guan J. Abstract 1831: Role of autophagy in lymphangiosarcoma initiation and progression Cancer Research. 79: 1831-1831. DOI: 10.1158/1538-7445.Am2019-1831  0.438
2018 Yeo SK, Paul R, Haas M, Wang C, Guan JL. Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer. Autophagy. PMID 29938573 DOI: 10.1080/15548627.2018.1460010  0.74
2018 Choi HK, Yuan H, Fang F, Wei X, Liu L, Li Q, Guan JL, Liu F. Tsc1 regulates the balance between osteoblast and adipocyte differentiation through autophagy/Notch1/β-catenin cascade. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 29924882 DOI: 10.1002/Jbmr.3530  0.302
2018 Nwadike C, Williamson LE, Gallagher LE, Guan JL, Chan EYW. AMPK inhibits ULK1-dependent autophagosome formation and lysosomal acidification via distinct mechanisms. Molecular and Cellular Biology. PMID 29507183 DOI: 10.1128/Mcb.00023-18  0.357
2018 Thiagarajan PS, Sinyuk M, Turaga SM, Mulkearns-Hubert EE, Hale JS, Rao V, Demelash A, Saygin C, China A, Alban TJ, Hitomi M, Torre-Healy LA, Alvarado AG, Jarrar A, Wiechert A, ... ... Guan JL, et al. Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase. Nature Communications. 9: 578. PMID 29422613 DOI: 10.1038/S41467-018-02938-1  0.339
2018 Sun S, Wu HJ, Guan JL. Nuclear FAK and its kinase activity regulate VEGFR2 transcription in angiogenesis of adult mice. Scientific Reports. 8: 2550. PMID 29416084 DOI: 10.1038/S41598-018-20930-Z  0.441
2018 Yeo SK, Paul R, Haas M, Wang C, Guan J. Abstract B21: Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer Molecular Cancer Research. 16. DOI: 10.1158/1557-3125.Advbc17-B21  0.401
2018 Okamoto T, Chen S, Yeo S, Guan J. Abstract 1327: Autophagy facilitates tumor promotion in PyMT tumors through up-regulation of Pparg Cancer Research. 78: 1327-1327. DOI: 10.1158/1538-7445.Am2018-1327  0.353
2017 Xia H, Wang W, Crespo J, Kryczek I, Li W, Wei S, Bian Z, Maj T, He M, Liu RJ, He Y, Rattan R, Munkarah A, Guan JL, Zou W. Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity. Science Immunology. 2. PMID 29150439 DOI: 10.1126/Sciimmunol.Aan4631  0.389
2017 Yeo SK, Guan JL. Breast Cancer: Multiple Subtypes within a Tumor? Trends in Cancer. 3: 753-760. PMID 29120751 DOI: 10.1016/J.Trecan.2017.09.001  0.728
2017 Wang B, Iyengar R, Li-Harms X, Joo JH, Wright C, Lavado A, Horner L, Yang M, Guan JL, Frase S, Green DR, Cao X, Kundu M. The Autophagy-Inducing Kinases, ULK1 and ULK2, Regulate Axon Guidance in the Developing Mouse Forebrain via a Noncanonical Pathway. Autophagy. 0. PMID 29099309 DOI: 10.1080/15548627.2017.1386820  0.313
2017 Ruiz-Torres SJ, Benight NM, Karns RA, Lower EE, Guan JL, Waltz SE. HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical β-catenin signaling. Oncotarget. 8: 58918-58933. PMID 28938607 DOI: 10.18632/Oncotarget.19441  0.457
2017 Ruiz-Torres SJ, Benight NM, Karns RA, Lower EE, Guan JL, Waltz SE. HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical β-catenin signaling. Oncotarget. PMID 28753558 DOI: 10.18632/oncotarget.19441  0.35
2017 Wang C, Yeo S, Haas MA, Guan JL. Autophagy gene FIP200 in neural progenitors non-cell autonomously controls differentiation by regulating microglia. The Journal of Cell Biology. PMID 28634261 DOI: 10.1083/Jcb.201609093  0.755
2017 Wacker R, Eickel N, Schmuckli-Maurer J, Annoura T, Niklaus L, Khan SM, Guan JL, Heussler VT. LC3-association with the parasitophorous vacuole membrane of Plasmodium berghei liver stages follows a non-canonical autophagy pathway. Cellular Microbiology. PMID 28573684 DOI: 10.1111/Cmi.12754  0.333
2017 Chen X, Clark J, Wunderlich M, Fan C, Davis A, Chen S, Guan JL, Mulloy JC, Kumar A, Zheng Y. Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine. Autophagy. 1-12. PMID 28282266 DOI: 10.1080/15548627.2017.1287652  0.386
2017 Paul R, Yeo SK, Luo M, Waltz S, Guan J. Abstract 5882: FAK is required for the survival of tumor cells in MMTV-Wnt1 driven basal-like mammary tumors Cancer Research. 77: 5882-5882. DOI: 10.1158/1538-7445.Am2017-5882  0.325
2016 Yeo SK, Guan JL. Hierarchical heterogeneity in mammary tumors and its regulation by autophagy. Autophagy. 1-2. PMID 27624535 DOI: 10.1080/15548627.2016.1213928  0.747
2016 Yeo SK, Wen J, Chen S, Guan JL. Autophagy differentially regulates distinct breast cancer stem-like cells in murine models via EGFR/Stat3 and Tgfß/Smad signaling. Cancer Research. PMID 27197172 DOI: 10.1158/0008-5472.Can-15-2946  0.766
2016 Chen S, Wang C, Yeo S, Liang CC, Okamoto T, Sun S, Wen J, Guan JL. Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model. Genes & Development. PMID 27013233 DOI: 10.1101/gad.276428.115  0.719
2016 Wang C, Chen S, Yeo S, Karsli-Uzunbas G, White E, Mizushima N, Virgin HW, Guan JL. Correction: Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide. The Journal of Cell Biology. PMID 27002165 DOI: 10.1083/jcb.20150702303082016c  0.692
2016 Wang C, Chen S, Yeo S, Karsli-Uzunbas G, White E, Mizushima N, Virgin HW, Guan JL. Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide. The Journal of Cell Biology. 212: 545-60. PMID 26929451 DOI: 10.1083/Jcb.201507023  0.74
2016 Chen X, Zheng Y, Fan C, Chen S, Guan J. mTOR Is Dispensable in Hematopoietic Stem Cells and GMP Progenitors, but Plays an Essential Role in the CMP Population, for Autophagy Regulation Blood. 128: 3864-3864. DOI: 10.1182/Blood.V128.22.3864.3864  0.431
2016 Sun S, Chen S, Liu F, Wu H, McHugh J, Bergin I, Gupta A, Adams D, Guan J. Abstract LB-038: Constitutive activation of mTORC1 in endothelial cells leads to the development and progression of lymphangiosarcoma through VEGF autocrine signaling Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-038  0.397
2016 Luo M, Wicha MS, Guan J. Abstract 1627: Kinase-independent function of focal adhesion kinase in lung metastasis of breast cancer Cancer Research. 76: 1627-1627. DOI: 10.1158/1538-7445.Am2016-1627  0.484
2015 Tai YL, Chu PY, Lai IR, Wang MY, Tseng HY, Guan JL, Liou JY, Shen TL. An EGFR/Src-dependent β4 integrin/FAK complex contributes to malignancy of breast cancer. Scientific Reports. 5: 16408. PMID 26549523 DOI: 10.1038/Srep16408  0.605
2015 Martinez J, Malireddi RK, Lu Q, Cunha LD, Pelletier S, Gingras S, Orchard R, Guan JL, Tan H, Peng J, Kanneganti TD, Virgin HW, Green DR. Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins. Nature Cell Biology. 17: 893-906. PMID 26098576 DOI: 10.1038/Ncb3192  0.315
2015 Wen J, Yeo S, Wang C, Chen S, Sun S, Haas MA, Tu W, Jin F, Guan JL. Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis. Breast Cancer Research and Treatment. 149: 619-29. PMID 25638397 DOI: 10.1007/S10549-015-3283-9  0.72
2015 Hsieh YH, van der Heyde H, Oh ES, Guan JL, Chang PL. Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: an Arg-Gly-Asp-dependent-focal adhesion kinase-caspase-8 axis. Molecular Carcinogenesis. 54: 379-92. PMID 24249517 DOI: 10.1002/Mc.22108  0.462
2015 Chen X, Clark J, Guan J, Kumar AR, Zheng Y. Susceptibility of AML to Chloroquine Therapy Is Independent of Autophagy Blood. 126: 1262-1262. DOI: 10.1182/Blood.V126.23.1262.1262  0.424
2015 Yeo SK, Wen J, Chen S, Guan J. Abstract 4228: Identification of distinct mammary cancer stem cells with differential requirements for the autophagy regulator FIP200 Cancer Research. 75: 4228-4228. DOI: 10.1158/1538-7445.Am2015-4228  0.396
2015 Martin EE, Huang W, Guan J, Kleer CG. Abstract 4188: Conditional epithelial cell-specific knockout of CCN6/Wisp3 disrupts normal development of the virgin murine mammary gland Cancer Research. 75: 4188-4188. DOI: 10.1158/1538-7445.Am2015-4188  0.413
2014 Qu H, Tu Y, Guan JL, Xiao G, Wu C. Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit. The Journal of Biological Chemistry. 289: 31001-13. PMID 25237194 DOI: 10.1074/Jbc.M114.580811  0.447
2014 Chen Y, Wei H, Liu F, Guan JL. Hyperactivation of mammalian target of rapamycin complex 1 (mTORC1) promotes breast cancer progression through enhancing glucose starvation-induced autophagy and Akt signaling. The Journal of Biological Chemistry. 289: 1164-73. PMID 24275666 DOI: 10.1074/jbc.M113.526335  0.377
2013 Chen S, Guan JL. Tumor-promoting and -suppressive roles of autophagy in the same mouse model of BrafV600E-driven lung cancer. Cancer Discovery. 3: 1225-7. PMID 24203955 DOI: 10.1158/2159-8290.Cd-13-0664  0.39
2013 Fujita N, Morita E, Itoh T, Tanaka A, Nakaoka M, Osada Y, Umemoto T, Saitoh T, Nakatogawa H, Kobayashi S, Haraguchi T, Guan JL, Iwai K, Tokunaga F, Saito K, et al. Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin. The Journal of Cell Biology. 203: 115-28. PMID 24100292 DOI: 10.1083/Jcb.201304188  0.318
2013 Jin Y, Liu Y, Lin Q, Li J, Druso JE, Antonyak MA, Meininger CJ, Zhang SL, Dostal DE, Guan JL, Cerione RA, Peng X. Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis. Molecular and Cellular Biology. 33: 4181-97. PMID 23979594 DOI: 10.1128/Mcb.00650-13  0.377
2013 Luo M, Zhao X, Chen S, Liu S, Wicha MS, Guan JL. Distinct FAK activities determine progenitor and mammary stem cell characteristics. Cancer Research. 73: 5591-602. PMID 23832665 DOI: 10.1158/0008-5472.Can-13-1351  0.401
2013 Schmidt TT, Tauseef M, Yue L, Bonini MG, Gothert J, Shen TL, Guan JL, Predescu S, Sadikot R, Mehta D. Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities. American Journal of Physiology. Lung Cellular and Molecular Physiology. 305: L291-300. PMID 23771883 DOI: 10.1152/Ajplung.00094.2013  0.561
2013 Ritt M, Guan JL, Sivaramakrishnan S. Visualizing and manipulating focal adhesion kinase regulation in live cells. The Journal of Biological Chemistry. 288: 8875-86. PMID 23393139 DOI: 10.1074/Jbc.M112.421164  0.331
2013 Fan H, Zhao X, Sun S, Luo M, Guan JL. Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo. The Journal of Biological Chemistry. 288: 3322-33. PMID 23255596 DOI: 10.1074/Jbc.M112.420497  0.376
2013 Monastyrska I, Ulasli M, Rottier PJ, Guan JL, Reggiori F, de Haan CA. An autophagy-independent role for LC3 in equine arteritis virus replication. Autophagy. 9: 164-74. PMID 23182945 DOI: 10.4161/Auto.22743  0.32
2013 Peng X, Lin Q, Liu Y, Jin Y, Druso JE, Antonyak MA, Guan JL, Cerione RA. Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice. Protein & Cell. 4: 231-42. PMID 23150167 DOI: 10.1007/S13238-012-2098-2  0.354
2012 Cai GQ, Chou CF, Hu M, Zheng A, Reichardt LF, Guan JL, Fang H, Luckhardt TR, Zhou Y, Thannickal VJ, Ding Q. Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of α-smooth muscle actin filaments during myofibroblast differentiation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 303: L692-702. PMID 22886502 DOI: 10.1152/Ajplung.00390.2011  0.353
2012 Petridou NI, Stylianou P, Christodoulou N, Rhoads D, Guan JL, Skourides PA. Activation of endogenous FAK via expression of its amino terminal domain in Xenopus embryos. Plos One. 7: e42577. PMID 22880041 DOI: 10.1371/Journal.Pone.0042577  0.799
2012 Chen XL, Nam JO, Jean C, Lawson C, Walsh CT, Goka E, Lim ST, Tomar A, Tancioni I, Uryu S, Guan JL, Acevedo LM, Weis SM, Cheresh DA, Schlaepfer DD. VEGF-induced vascular permeability is mediated by FAK. Developmental Cell. 22: 146-57. PMID 22264731 DOI: 10.1016/J.Devcel.2011.11.002  0.374
2012 Wei H, Guan JL. Pro-tumorigenic function of autophagy in mammary oncogenesis. Autophagy. 8: 129-31. PMID 22082959 DOI: 10.4161/auto.8.1.18171  0.374
2012 Thennes T, Tauseef M, Bonini M, Gothert J, Shen T, Guan J, Sadikot R, Mehta D. Endothelial Focal adhesion kinase maintains lung fluid balance and prevents cytokine storm The Faseb Journal. 26. DOI: 10.1096/Fasebj.26.1_Supplement.1063.8  0.562
2011 Li XY, Zhou X, Rowe RG, Hu Y, Schlaepfer DD, Ilić D, Dressler G, Park A, Guan JL, Weiss SJ. Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells Journal of Cell Biology. 195: 729-738. PMID 22105351 DOI: 10.1083/Jcb.201105103  0.367
2011 Bae H, Guan JL. Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents. Molecular Cancer Research : McR. 9: 1232-41. PMID 21807966 DOI: 10.1158/1541-7786.Mcr-11-0098  0.339
2011 Seong J, Ouyang M, Kim T, Sun J, Wen PC, Lu S, Zhuo Y, Llewellyn NM, Schlaepfer DD, Guan JL, Chien S, Wang Y. Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer. Nature Communications. 2: 406. PMID 21792185 DOI: 10.1038/Ncomms1414  0.356
2011 Wei H, Wei S, Gan B, Peng X, Zou W, Guan JL. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes & Development. 25: 1510-27. PMID 21764854 DOI: 10.1101/Gad.2051011  0.583
2011 Kageyama S, Omori H, Saitoh T, Sone T, Guan JL, Akira S, Imamoto F, Noda T, Yoshimori T. The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella. Molecular Biology of the Cell. 22: 2290-300. PMID 21525242 DOI: 10.1091/Mbc.E10-11-0893  0.351
2011 Fan H, Guan JL. Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity. The Journal of Biological Chemistry. 286: 18573-82. PMID 21471206 DOI: 10.1074/Jbc.M110.200717  0.517
2011 Peng X, Guan JL. Focal adhesion kinase: from in vitro studies to functional analyses in vivo. Current Protein & Peptide Science. 12: 52-67. PMID 21190526 DOI: 10.2174/138920311795659452  0.502
2011 Zhao X, Guan JL. Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis. Advanced Drug Delivery Reviews. 63: 610-5. PMID 21118706 DOI: 10.1016/j.addr.2010.11.001  0.412
2011 Liu F, Guan JL. FIP200, an essential component of mammalian autophagy is indispensible for fetal hematopoiesis. Autophagy. 7: 229-30. PMID 21088496 DOI: 10.4161/auto.7.2.14125  0.322
2010 Liu F, Lee JY, Wei H, Tanabe O, Engel JD, Morrison SJ, Guan JL. FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells. Blood. 116: 4806-14. PMID 20716775 DOI: 10.1182/blood-2010-06-288589  0.303
2010 Wang C, Yoo Y, Fan H, Kim E, Guan KL, Guan JL. Regulation of Integrin β 1 recycling to lipid rafts by Rab1a to promote cell migration. The Journal of Biological Chemistry. 285: 29398-405. PMID 20639577 DOI: 10.1074/Jbc.M110.141440  0.421
2010 Guan JL. Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer. Iubmb Life. 62: 268-76. PMID 20101634 DOI: 10.1002/Iub.303  0.512
2010 Ginestier C, Liu S, Diebel ME, Korkaya H, Luo M, Brown M, Wicinski J, Cabaud O, Charafe-Jauffret E, Birnbaum D, Guan JL, Dontu G, Wicha MS. CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. The Journal of Clinical Investigation. 120: 485-97. PMID 20051626 DOI: 10.1172/Jci39397  0.304
2010 Liang CC, Wang C, Peng X, Gan B, Guan JL. Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration. The Journal of Biological Chemistry. 285: 3499-509. PMID 19940130 DOI: 10.1074/Jbc.M109.072389  0.517
2010 Yoo Y, Ho HJ, Wang C, Guan J. Tyrosine Phosphorylation Of Cofilin At Y68 By V-Src Leads To Its Degradation Through Ubiquitin-Proteasome Pathway Oncogene. 29: 263-272. PMID 19802004 DOI: 10.1038/Onc.2009.319  0.348
2010 Luo M, Guan JL. Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer Letters. 289: 127-39. PMID 19643531 DOI: 10.1016/J.Canlet.2009.07.005  0.394
2010 Nam J, Acevedo LM, Goka E, Chen XL, Walsh C, Tanjoni I, Guan J, Weis SM, Cheresh DA, Schlaepfer DD. Abstract 389: Mice with kinase-dead FAK mutation in endothelial cells are protected from VEGF-induced permeability and are resistant to tumor cell metastasis Cancer Research. 70: 389-389. DOI: 10.1158/1538-7445.Am10-389  0.382
2009 Chu PY, Huang LY, Hsu CH, Liang CC, Guan JL, Hung TH, Shen TL. Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis. The Journal of Biological Chemistry. 284: 20215-26. PMID 19473962 DOI: 10.1074/jbc.M109.018259  0.628
2009 Park AY, Shen TL, Chien S, Guan JL. Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis. The Journal of Biological Chemistry. 284: 9418-25. PMID 19201755 DOI: 10.1074/Jbc.M809040200  0.639
2009 Zhao J, Guan JL. Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Reviews. 28: 35-49. PMID 19169797 DOI: 10.1007/S10555-008-9165-4  0.498
2009 Luo M, Fan H, Nagy T, Wei H, Wang C, Liu S, Wicha MS, Guan JL. Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Research. 69: 466-74. PMID 19147559 DOI: 10.1158/0008-5472.Can-08-3078  0.576
2009 Wei H, Gan B, Wu X, Guan JL. Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models. The Journal of Biological Chemistry. 284: 6004-13. PMID 19106106 DOI: 10.1074/Jbc.M806375200  0.661
2008 Peng X, Wu X, Druso JE, Wei H, Park AY, Kraus MS, Alcaraz A, Chen J, Chien S, Cerione RA, Guan JL. Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 6638-43. PMID 18448675 DOI: 10.1073/Pnas.0802319105  0.49
2008 Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N. FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. The Journal of Cell Biology. 181: 497-510. PMID 18443221 DOI: 10.1083/jcb.200712064  0.345
2008 Weis SM, Lim ST, Lutu-Fuga KM, Barnes LA, Chen XL, Göthert JR, Shen TL, Guan JL, Schlaepfer DD, Cheresh DA. Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. The Journal of Cell Biology. 181: 43-50. PMID 18391070 DOI: 10.1083/Jcb.200710038  0.609
2008 Martin N, Schwamborn K, Urlaub H, Gan B, Guan JL, Dejean A. Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity. Molecular and Cellular Biology. 28: 2771-81. PMID 18285457 DOI: 10.1128/Mcb.01210-07  0.545
2008 Gan B, Guan JL. FIP200, a key signaling node to coordinately regulate various cellular processes. Cellular Signalling. 20: 787-94. PMID 18036779 DOI: 10.1016/J.Cellsig.2007.10.021  0.572
2008 Luo M, Nagy T, Guan J. The role of focal adhesion kinase in mammary stem cell and tumorigenesis Cell Research. 18: S98-S98. DOI: 10.1038/Cr.2008.188  0.597
2007 Nagy T, Wei H, Shen TL, Peng X, Liang CC, Gan B, Guan JL. Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland. The Journal of Biological Chemistry. 282: 31766-76. PMID 17716968 DOI: 10.1074/Jbc.M705403200  0.745
2007 Rhoads DS, Guan JL. Analysis of directional cell migration on defined FN gradients: role of intracellular signaling molecules. Experimental Cell Research. 313: 3859-67. PMID 17640633 DOI: 10.1016/J.Yexcr.2007.06.005  0.796
2007 Yoo Y, Wu X, Guan JL. A novel role of the actin-nucleating Arp2/3 complex in the regulation of RNA polymerase II-dependent transcription. The Journal of Biological Chemistry. 282: 7616-23. PMID 17220302 DOI: 10.1074/Jbc.M607596200  0.517
2006 Gan B, Yoo Y, Guan JL. Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth. The Journal of Biological Chemistry. 281: 37321-9. PMID 17043358 DOI: 10.1074/Jbc.M605241200  0.621
2006 Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL. Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways. The Journal of Cell Biology. 175: 121-33. PMID 17015619 DOI: 10.1083/Jcb.200604129  0.694
2006 Feng Q, Baird D, Peng X, Wang J, Ly T, Guan JL, Cerione RA. Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth. Nature Cell Biology. 8: 945-56. PMID 16892055 DOI: 10.1038/Ncb1453  0.397
2006 Wu X, Yoo Y, Okuhama NN, Tucker PW, Liu G, Guan JL. Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners. Nature Cell Biology. 8: 756-63. PMID 16767080 DOI: 10.1038/Ncb1433  0.508
2006 Wei H, Wang X, Gan B, Urvalek AM, Melkoumian ZK, Guan JL, Zhao J. Sumoylation delimits KLF8 transcriptional activity associated with the cell cycle regulation. The Journal of Biological Chemistry. 281: 16664-71. PMID 16617055 DOI: 10.1074/Jbc.M513135200  0.521
2006 Yoo Y, Wu X, Egile C, Li R, Guan JL. Interaction of N-WASP with hnRNPK and its role in filopodia formation and cell spreading. The Journal of Biological Chemistry. 281: 15352-60. PMID 16574661 DOI: 10.1074/Jbc.M511825200  0.469
2006 Peng X, Kraus MS, Wei H, Shen TL, Pariaut R, Alcaraz A, Ji G, Cheng L, Yang Q, Kotlikoff MI, Chen J, Chien K, Gu H, Guan JL. Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice. The Journal of Clinical Investigation. 116: 217-27. PMID 16374517 DOI: 10.1172/Jci24497  0.512
2005 Cohen LA, Guan JL. Mechanisms of focal adhesion kinase regulation. Current Cancer Drug Targets. 5: 629-43. PMID 16375667 DOI: 10.2174/156800905774932798  0.476
2005 Pongchairerk U, Guan JL, Leardkamolkarn V. Focal adhesion kinase and Src phosphorylations in HGF-induced proliferation and invasion of human cholangiocarcinoma cell line, HuCCA-1. World Journal of Gastroenterology. 11: 5845-52. PMID 16270396 DOI: 10.3748/Wjg.V11.I37.5845  0.433
2005 Melkoumian ZK, Peng X, Gan B, Wu X, Guan JL. Mechanism of cell cycle regulation by FIP200 in human breast cancer cells. Cancer Research. 65: 6676-84. PMID 16061648 DOI: 10.1158/0008-5472.Can-04-4142  0.687
2005 Wu X, Gan B, Yoo Y, Guan JL. FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation. Developmental Cell. 9: 185-96. PMID 16054026 DOI: 10.1016/J.Devcel.2005.06.006  0.648
2005 Gan B, Melkoumian ZK, Wu X, Guan KL, Guan JL. Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. The Journal of Cell Biology. 170: 379-89. PMID 16043512 DOI: 10.1083/Jcb.200411106  0.679
2005 Li S, Guan JL, Chien S. Biochemistry and biomechanics of cell motility. Annual Review of Biomedical Engineering. 7: 105-50. PMID 16004568 DOI: 10.1146/Annurev.Bioeng.7.060804.100340  0.389
2005 Shen TL, Park AY, Alcaraz A, Peng X, Jang I, Koni P, Flavell RA, Gu H, Guan JL. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. The Journal of Cell Biology. 169: 941-52. PMID 15967814 DOI: 10.1083/Jcb.200411155  0.574
2005 Cohen LA, Guan JL. Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation. The Journal of Biological Chemistry. 280: 8197-207. PMID 15611137 DOI: 10.1074/Jbc.M412021200  0.409
2005 Rhoads DS, Nadkarni SM, Song L, Voeltz C, Bodenschatz E, Guan JL. Using microfluidic channel networks to generate gradients for studying cell migration. Methods in Molecular Biology (Clifton, N.J.). 294: 347-57. PMID 15576923 DOI: 10.1385/1-59259-860-9:347  0.752
2005 Rodriguez LG, Wu X, Guan JL. Wound-healing assay. Methods in Molecular Biology (Clifton, N.J.). 294: 23-9. PMID 15576902 DOI: 10.1385/1-59259-860-9:023  0.538
2005 Ding Q, Grammer JR, Nelson MA, Guan JL, Stewart JE, Gladson CL. p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain. The Journal of Biological Chemistry. 280: 6802-15. PMID 15557280 DOI: 10.1074/jbc.M409180200  0.316
2005 Miao H, Strebhardt K, Pasquale EB, Shen TL, Guan JL, Wang B. Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases. The Journal of Biological Chemistry. 280: 923-32. PMID 15536074 DOI: 10.1074/jbc.M411383200  0.622
2005 Rodriguez LG, Guan JL. 14-3-3 regulation of cell spreading and migration requires a functional amphipathic groove. Journal of Cellular Physiology. 202: 285-94. PMID 15389601 DOI: 10.1002/Jcp.20122  0.36
2004 Peng X, Ueda H, Zhou H, Stokol T, Shen TL, Alcaraz A, Nagy T, Vassalli JD, Guan JL. Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice. Cardiovascular Research. 64: 421-30. PMID 15537495 DOI: 10.1016/J.Cardiores.2004.07.012  0.69
2004 Li W, Lee J, Vikis HG, Lee SH, Liu G, Aurandt J, Shen TL, Fearon ER, Guan JL, Han M, Rao Y, Hong K, Guan KL. Activation of FAK and Src are receptor-proximal events required for netrin signaling. Nature Neuroscience. 7: 1213-21. PMID 15494734 DOI: 10.1038/Nn1329  0.531
2004 Shen TL, Guan JL. Grb7 in intracellular signaling and its role in cell regulation. Frontiers in Bioscience : a Journal and Virtual Library. 9: 192-200. PMID 14766359 DOI: 10.2741/1229  0.627
2004 Guan JL. Cell biology. Integrins, rafts, Rac, and Rho. Science (New York, N.Y.). 303: 773-4. PMID 14764856 DOI: 10.1126/Science.1094376  0.346
2004 Wu X, Suetsugu S, Cooper LA, Takenawa T, Guan JL. Focal adhesion kinase regulation of N-WASP subcellular localization and function. The Journal of Biological Chemistry. 279: 9565-76. PMID 14676198 DOI: 10.1074/Jbc.M310739200  0.572
2003 Cooper LA, Shen TL, Guan JL. Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction. Molecular and Cellular Biology. 23: 8030-41. PMID 14585964 DOI: 10.1128/Mcb.23.22.8030-8041.2003  0.634
2003 Zhao J, Bian ZC, Yee K, Chen BP, Chien S, Guan JL. Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Molecular Cell. 11: 1503-15. PMID 12820964 DOI: 10.1016/S1097-2765(03)00179-5  0.334
2002 Abbi S, Guan JL. Focal adhesion kinase: protein interactions and cellular functions. Histology and Histopathology. 17: 1163-71. PMID 12371144  0.715
2002 Han DC, Shen TL, Miao H, Wang B, Guan JL. EphB1 associates with Grb7 and regulates cell migration. The Journal of Biological Chemistry. 277: 45655-61. PMID 12223469 DOI: 10.1074/jbc.M203165200  0.599
2002 Abbi S, Ueda H, Zheng C, Cooper LA, Zhao J, Christopher R, Guan JL. Regulation of focal adhesion kinase by a novel protein inhibitor FIP200. Molecular Biology of the Cell. 13: 3178-91. PMID 12221124 DOI: 10.1091/Mbc.E02-05-0295  0.75
2002 Shen TL, Han DC, Guan JL. Association of Grb7 with phosphoinositides and its role in the regulation of cell migration. The Journal of Biological Chemistry. 277: 29069-77. PMID 12021278 DOI: 10.1074/Jbc.M203085200  0.63
2002 Goicoechea SM, Tu Y, Hua Y, Chen K, Shen TL, Guan JL, Wu C. Nck-2 interacts with focal adhesion kinase and modulates cell motility. The International Journal of Biochemistry & Cell Biology. 34: 791-805. PMID 11950595 DOI: 10.1016/S1357-2725(02)00002-X  0.626
2002 Li S, Butler P, Wang Y, Hu Y, Han DC, Usami S, Guan JL, Chien S. The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 99: 3546-51. PMID 11891289 DOI: 10.1073/Pnas.052018099  0.369
2001 Zhao J, Pestell R, Guan JL. Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression Molecular Biology of the Cell. 12: 4066-4077. PMID 11739801 DOI: 10.1091/Mbc.12.12.4066  0.43
2001 Han DC, Shen TL, Guan JL. The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions. Oncogene. 20: 6315-21. PMID 11607834 DOI: 10.1038/Sj.Onc.1204775  0.601
2001 Yang W, Lin Q, Zhao J, Guan JL, Cerione RA. The nonreceptor tyrosine kinase ACK2, a specific target for Cdc42 and a negative regulator of cell growth and focal adhesion complexes. The Journal of Biological Chemistry. 276: 43987-93. PMID 11535592 DOI: 10.1074/Jbc.M104819200  0.44
2001 Shen TL, Guan JL. Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts. Febs Letters. 499: 176-81. PMID 11418135 DOI: 10.1016/S0014-5793(01)02545-5  0.646
2001 Han DC, Rodriguez LG, Guan J. Identification of a novel interaction between integrin β1 and 14-3-3β Oncogene. 20: 346-357. PMID 11313964 DOI: 10.1038/Sj.Onc.1204068  0.333
2000 Reiske HR, Zhao J, Han DC, Cooper LA, Guan JL. Analysis of FAK-associated signaling pathways in the regulation of cell cycle progression. Febs Letters. 486: 275-80. PMID 11119718 DOI: 10.1016/S0014-5793(00)02295-X  0.818
2000 Zhao J, Guan J. Role of focal adhesion kinase in signaling by the extracellular matrix. Progress in Molecular and Subcellular Biology. 25: 37-55. PMID 10986717 DOI: 10.1007/978-3-642-59766-4_3  0.412
2000 Han DC, Shen TL, Guan JL. Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration. The Journal of Biological Chemistry. 275: 28911-7. PMID 10893408 DOI: 10.1074/Jbc.M001997200  0.645
2000 Ueda H, Abbi S, Zheng C, Guan JL. Suppression of Pyk2 kinase and cellular activities by FIP200. The Journal of Cell Biology. 149: 423-30. PMID 10769033 DOI: 10.1083/Jcb.149.2.423  0.719
1999 Eisenmann KM, McCarthy JB, Simpson MA, Keely PJ, Guan JL, Tachibana K, Lim L, Manser E, Furcht LT, Iida J. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas Nature Cell Biology. 1: 507-513. PMID 10587647 DOI: 10.1038/70302  0.339
1999 Han DC, Guan J. Association of focal adhesion kinase with Grb7 and its role in cell migration. Journal of Biological Chemistry. 274: 24425-24430. PMID 10446223 DOI: 10.1074/Jbc.274.34.24425  0.478
1999 Reiske HR, Kao SC, Cary LA, Guan JL, Lai JF, Chen HC. Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration. The Journal of Biological Chemistry. 274: 12361-6. PMID 10212207 DOI: 10.1074/jbc.274.18.12361  0.811
1999 Yang W, Lin Q, Guan JL, Cerione RA. Activation of the Cdc42-associated tyrosine kinase-2 (ACK-2) by cell adhesion via integrin beta1. The Journal of Biological Chemistry. 274: 8524-30. PMID 10085085 DOI: 10.1074/Jbc.274.13.8524  0.445
1998 Zhao JH, Reiske H, Guan JL. Regulation of the cell cycle by focal adhesion kinase. The Journal of Cell Biology. 143: 1997-2008. PMID 9864370 DOI: 10.1083/Jcb.143.7.1997  0.812
1998 Cary LA, Han DC, Polte TR, Hanks SK, Guan JL. Identification of p130(Cas) as a mediator of focal adhesion kinase- promoted cell migration Journal of Cell Biology. 140: 211-221. PMID 9425168 DOI: 10.1083/jcb.140.1.211  0.308
1997 Guan JL. Role of focal adhesion kinase in integrin signaling International Journal of Biochemistry and Cell Biology. 29: 1085-1096. PMID 9416004 DOI: 10.1016/S1357-2725(97)00051-4  0.467
1997 Guan JL. Focal adhesion kinase in integrin signaling Matrix Biology. 16: 195-200. PMID 9402009 DOI: 10.1016/S0945-053X(97)90008-1  0.36
1996 Chen H, Appeddu PA, Isoda H, Guan J. Phosphorylation of Tyrosine 397 in Focal Adhesion Kinase Is Required for Binding Phosphatidylinositol 3-Kinase Journal of Biological Chemistry. 271: 26329-26334. PMID 8824286 DOI: 10.1074/Jbc.271.42.26329  0.388
1995 Chen HC, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan JL. Interaction of focal adhesion kinase with cytoskeletal protein talin Journal of Biological Chemistry. 270: 16995-16999. PMID 7622520 DOI: 10.1074/Jbc.270.28.16995  0.472
1994 Xing Z, Chen HC, Nowlen JK, Taylor SJ, Shalloway D, Guan JL. Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain Molecular Biology of the Cell. 5: 413-421. PMID 8054685 DOI: 10.1091/Mbc.5.4.413  0.419
1992 Hynes RO, George EL, Georges EN, Guan JL, Rayburn H, Yang JT. Toward a genetic analysis of cell-matrix adhesion. Cold Spring Harbor Symposia On Quantitative Biology. 57: 249-58. PMID 1339663 DOI: 10.1101/Sqb.1992.057.01.030  0.437
1991 Guan JL, Trevithick JE, Hynes RO. Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regulation. 2: 951-64. PMID 1725602 DOI: 10.1091/Mbc.2.11.951  0.519
1990 Guan JL, Trevithick JE, Hynes RO. Retroviral expression of alternatively spliced forms of rat fibronectin. The Journal of Cell Biology. 110: 833-47. PMID 2307710 DOI: 10.1083/Jcb.110.3.833  0.47
1990 Guan JL, Hynes RO. Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1. Cell. 60: 53-61. PMID 2295088 DOI: 10.1016/0092-8674(90)90715-Q  0.446
1990 Marcantonio EE, Guan JL, Trevithick JE, Hynes RO. Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis. Cell Regulation. 1: 597-604. PMID 2078570 DOI: 10.1091/Mbc.1.8.597  0.662
1989 Solowska J, Guan JL, Marcantonio EE, Trevithick JE, Buck CA, Hynes RO. Expression of normal and mutant avian integrin subunits in rodent cells. The Journal of Cell Biology. 109: 853-61. PMID 2788168 DOI: 10.1083/Jcb.109.2.853  0.67
1988 Guan JL, Ruusala A, Cao H, Rose JK. Effects of altered cytoplasmic domains on transport of the vesicular stomatitis virus glycoprotein are transferable to other proteins. Molecular and Cellular Biology. 8: 2869-74. PMID 2841589  0.41
1988 Fukuda M, Guan JL, Rose JK. A membrane-anchored form but not the secretory form of human chorionic gonadotropin-alpha chain acquires polylactosaminoglycan. The Journal of Biological Chemistry. 263: 5314-8. PMID 2451668  0.39
1988 Guan JL, Cao H, Rose JK. Cell-surface expression of a membrane-anchored form of the human chorionic gonadotropin alpha subunit. The Journal of Biological Chemistry. 263: 5306-13. PMID 2451667  0.427
1985 Guan JL, Machamer CE, Rose JK. Glycosylation allows cell-surface transport of an anchored secretory protein. Cell. 42: 489-96. PMID 3928168 DOI: 10.1016/0092-8674(85)90106-0  0.444
1984 Guan JL, Rose JK. Conversion of a secretory protein into a transmembrane protein results in its transport to the Golgi complex but not to the cell surface. Cell. 37: 779-87. PMID 6589049  0.417
Show low-probability matches.