Bibek Parajuli, Ph.D.
Affiliations: | 2013 | Biochemistry and Molecular Biology | Indiana University, Bloomington, Bloomington, IN, United States |
Area:
Biochemistry, Medicine and Surgery, Radiology, OncologyGoogle:
"Bibek Parajuli"Parents
Sign in to add mentor| Thomas D. Hurley | grad student | 2013 | Indiana University Bloomington | |
| (Identification, kinetic and structural characterization of small molecule inhibitors of aldehyde dehydrogenase 3a1 (ALDH3A1) as an adjuvant therapy for reversing cancer chemoresistance.) | ||||
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Publications
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| Gossert ST, Parajuli B, Chaiken I, et al. (2020) Roles of Variable Linker Length in Dual Acting Virucidal Entry Inhibitors on HIV-1 Potency via On-the-fly Free Energy Molecular Simulations. Protein Science : a Publication of the Protein Society |
| Parajuli B, Acharya K, Bach HC, et al. (2018) Restricted HIV-1 Env Glycan Engagement by Lectin-Reengineered DAVEI Protein Chimera is sufficient for Lytic Inactivation of the Virus. The Biochemical Journal |
| Parajuli B, Acharya K, Yu R, et al. (2016) Lytic Inactivation of HIV-1 by Dual Engagement of gp120 and gp41 Domains in the Virus Env Protein Trimer. Biochemistry |
| Morgan CA, Parajuli B, Buchman CD, et al. (2015) N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes. Chemico-Biological Interactions. 234: 18-28 |
| Parajuli B, Georgiadis TM, Fishel ML, et al. (2014) Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity. Chembiochem : a European Journal of Chemical Biology. 15: 701-12 |
| Kimble-Hill AC, Parajuli B, Chen CH, et al. (2014) Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones. Journal of Medicinal Chemistry. 57: 714-22 |
| Parajuli B, Fishel ML, Hurley TD. (2014) Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells. Journal of Medicinal Chemistry. 57: 449-61 |
| Khanna M, Chen CH, Kimble-Hill A, et al. (2011) Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases. The Journal of Biological Chemistry. 286: 43486-94 |
| Parajuli B, Kimble-Hill AC, Khanna M, et al. (2011) Discovery of novel regulators of aldehyde dehydrogenase isoenzymes. Chemico-Biological Interactions. 191: 153-8 |