Manuel Buchwald

University of Toronto, Toronto, ON, Canada 
Cell Biology
"Manuel Buchwald"


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William P. Jencks grad student 1968 Brandeis (Chemistry Tree)
 (Studies on astaxanthin and protein pigments from lobster shell.)
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Gordon SM, Alon N, Buchwald M. (2005) FANCC, FANCE, and FANCD2 form a ternary complex essential to the integrity of the Fanconi anemia DNA damage response pathway. The Journal of Biological Chemistry. 280: 36118-25
Brodeur I, Goulet I, Tremblay CS, et al. (2004) Regulation of the Fanconi anemia group C protein through proteolytic modification. The Journal of Biological Chemistry. 279: 4713-20
Wong JC, Gokgoz N, Alon N, et al. (2003) Cloning and mutation analysis of ZFP276 as a candidate tumor suppressor in breast cancer. Journal of Human Genetics. 48: 668-71
Wong JC, Alon N, Mckerlie C, et al. (2003) Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia. Human Molecular Genetics. 12: 2063-76
Gordon SM, Buchwald M. (2003) Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems. Blood. 102: 136-41
Yang Y, McKerlie C, Borenstein SH, et al. (2002) Transgenic expression in mouse lung reveals distinct biological roles for the adenovirus type 5 E1A 243- and 289-amino-acid proteins. Journal of Virology. 76: 8910-9
Wong JC, Buchwald M. (2002) Disease model: Fanconi anemia. Trends in Molecular Medicine. 8: 139-42
Hadjur S, Ung K, Wadsworth L, et al. (2001) Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase. Blood. 98: 1003-11
Cumming RC, Lightfoot J, Beard K, et al. (2001) Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1. Nature Medicine. 7: 814-20
Wong JC, Alon N, Norga K, et al. (2000) Cloning and analysis of the mouse Fanconi anemia group A cDNA and an overlapping penta zinc finger cDNA. Genomics. 67: 273-83
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