Justin A. Spanier, Ph.D.

2011 University of Wisconsin, Madison, Madison, WI 
"Justin Spanier"


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Colleen E. Hayes grad student 2011 UW Madison
 (Mechanisms of vitamin D-mediated suppression of experimental autoimmune encephalomyelitis.)
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Moore JR, Hubler SL, Nelson CD, et al. (2018) 1,25-Dihydroxyvitamin D increases the methionine cycle, CD4 T cell DNA methylation and HeliosFoxp3 T regulatory cells to reverse autoimmune neurodegenerative disease. Journal of Neuroimmunology. 324: 100-114
Spanier JA, Frederick DR, Taylor JJ, et al. (2016) Efficient generation of monoclonal antibodies against peptide in the context of MHCII using magnetic enrichment. Nature Communications. 7: 11804
Boontanrart M, Hall SD, Spanier JA, et al. (2016) Vitamin D3 alters microglia immune activation by an IL-10 dependent SOCS3 mechanism. Journal of Neuroimmunology. 292: 126-36
Spanier JA, Nashold FE, Mayne CG, et al. (2015) Vitamin D and estrogen synergy in Vdr-expressing CD4(+) T cells is essential to induce Helios(+)FoxP3(+) T cells and prevent autoimmune demyelinating disease. Journal of Neuroimmunology. 286: 48-58
Pauken KE, Nelson CE, Martinov T, et al. (2015) Cutting edge: identification of autoreactive CD4+ and CD8+ T cell subsets resistant to PD-1 pathway blockade. Journal of Immunology (Baltimore, Md. : 1950). 194: 3551-5
Nelson RW, Beisang D, Tubo NJ, et al. (2015) T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity. Immunity. 42: 95-107
Pauken KE, Linehan JL, Spanier JA, et al. (2013) Cutting edge: type 1 diabetes occurs despite robust anergy among endogenous insulin-specific CD4 T cells in NOD mice. Journal of Immunology (Baltimore, Md. : 1950). 191: 4913-7
Spanier JA, Nashold FE, Olson JK, et al. (2012) The Ifng gene is essential for Vdr gene expression and vitamin D₃-mediated reduction of the pathogenic T cell burden in the central nervous system in experimental autoimmune encephalomyelitis, a multiple sclerosis model. Journal of Immunology (Baltimore, Md. : 1950). 189: 3188-97
Mayne CG, Spanier JA, Relland LM, et al. (2011) 1,25-Dihydroxyvitamin D3 acts directly on the T lymphocyte vitamin D receptor to inhibit experimental autoimmune encephalomyelitis. European Journal of Immunology. 41: 822-32
Nashold FE, Spach KM, Spanier JA, et al. (2009) Estrogen controls vitamin D3-mediated resistance to experimental autoimmune encephalomyelitis by controlling vitamin D3 metabolism and receptor expression Journal of Immunology. 183: 3672-3681
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