Charles D. Loftin

Affiliations: 
University of Kentucky, Lexington, KY 
Area:
Pharmacology, Pharmacy, Molecular Biology
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"Charles Loftin"
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Publications

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Ding K, Zhou Z, Hou S, et al. (2018) Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs. Scientific Reports. 8: 5205
Adedoyin OO, Loftin CD. (2016) Microsomal Prostaglandin E Synthase-1 Expression by Aortic Smooth Muscle Cells Attenuates the Differentiated Phenotype. Journal of Cardiovascular Pharmacology
Oestreich JH, Steinhubl SR, Ferraris SP, et al. (2014) Effect of genetic variation in P2Y12 on TRAP-stimulated platelet response in healthy subjects. Journal of Thrombosis and Thrombolysis. 38: 372-9
Trivedi DB, Loftin CD, Clark J, et al. (2013) β-Arrestin-2 deficiency attenuates abdominal aortic aneurysm formation in mice. Circulation Research. 112: 1219-29
Ghoshal S, Loftin CD. (2012) Cyclooxygenase-2 inhibition attenuates abdominal aortic aneurysm progression in hyperlipidemic mice. Plos One. 7: e44369
Mukherjee K, Gitlin JM, Loftin CD. (2012) Effectiveness of cyclooxygenase-2 inhibition in limiting abdominal aortic aneurysm progression in mice correlates with a differentiated smooth muscle cell phenotype. Journal of Cardiovascular Pharmacology. 60: 520-9
Ghoshal S, Trivedi DB, Graf GA, et al. (2011) Cyclooxygenase-2 deficiency attenuates adipose tissue differentiation and inflammation in mice. The Journal of Biological Chemistry. 286: 889-98
Kelso ML, Scheff SW, Pauly JR, et al. (2009) Effects of genetic deficiency of cyclooxygenase-1 or cyclooxygenase-2 on functional and histological outcomes following traumatic brain injury in mice. Bmc Neuroscience. 10: 108
Gitlin JM, Loftin CD. (2009) Cyclooxygenase-2 inhibition increases lipopolysaccharide-induced atherosclerosis in mice. Cardiovascular Research. 81: 400-7
Gitlin JM, Trivedi DB, Langenbach R, et al. (2007) Genetic deficiency of cyclooxygenase-2 attenuates abdominal aortic aneurysm formation in mice. Cardiovascular Research. 73: 227-36
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