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Micah D. Gearhart, Ph.D. - Publications

Affiliations: 
2001 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
NMR
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39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Sadowski D, Corcoran CM, Abdi R, Zheng T, Okae H, Arima T, Bardwell VJ, Gearhart MD. Polycomb Repressive Complex 1.1 Component, BCOR, Promotes Syncytiotrophoblast Differentiation in Mice and Humans. Biorxiv : the Preprint Server For Biology. PMID 38352412 DOI: 10.1101/2024.01.29.577740  0.329
2022 Ru W, Koga T, Wang X, Guo Q, Gearhart MD, Zhao S, Murphy M, Kawakami H, Corcoran D, Zhang J, Zhu Z, Yao X, Kawakami Y, Xu C. Structural studies of SALL family protein zinc finger cluster domains in complex with DNA reveal preferential binding to an AATA tetranucleotide motif. The Journal of Biological Chemistry. 102607. PMID 36257403 DOI: 10.1016/j.jbc.2022.102607  0.314
2022 Murphy MW, Gearhart MD, Wheeler A, Bardwell VJ, Zarkower D. Genomics of sexual cell fate transdifferentiation in the mouse gonad. G3 (Bethesda, Md.). PMID 36200842 DOI: 10.1093/g3journal/jkac267  0.338
2022 Agrimson KS, Minkina A, Sadowski D, Wheeler A, Murphy MW, Gearhart MD, Bardwell VJ, Zarkower D. Lrh1 can help reprogram sexual cell fate and is required for Sertoli cell development and spermatogenesis in the mouse testis. Plos Genetics. 18: e1010088. PMID 35192609 DOI: 10.1371/journal.pgen.1010088  0.306
2021 Giefing M, Gearhart MD, Schneider M, Overbeck B, Klapper W, Hartmann S, Ustaszewski A, Weniger MA, Wiehle L, Hansmann ML, Melnick A, Béguelin W, Sundström C, Küppers R, Bardwell VJ, et al. Loss of function mutations of in classical Hodgkin lymphoma. Leukemia & Lymphoma. 1-11. PMID 34957890 DOI: 10.1080/10428194.2021.2015587  0.307
2020 Kutscher LM, Okonechnikov K, Batora NV, Clark J, Silva PBG, Vouri M, van Rijn S, Sieber L, Statz B, Gearhart MD, Shiraishi R, Mack N, Orr BA, Korshunov A, Gudenas BL, et al. Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation. Genes & Development. PMID 32820036 DOI: 10.1101/Gad.337584.120  0.395
2020 Hamline MY, Corcoran CM, Wamstad JA, Miletich I, Feng J, Lohr JL, Hemberger M, Sharpe PT, Gearhart MD, Bardwell VJ. OFCD syndrome and extraembryonic defects are revealed by conditional mutation of the polycomb-group repressive complex 1.1 (PRC1.1) gene BCOR. Developmental Biology. PMID 32692983 DOI: 10.1016/J.Ydbio.2020.06.013  0.356
2020 Wong SJ, Senkovich O, Artigas JA, Gearhart MD, Udayar I, Graham DW, Abel KN, Yu T, Hinck AP, Bardwell VJ, Kim CA. Structure and role of BCOR PUFD in non-canonical PRC1 assembly and disease. Biochemistry. PMID 32628469 DOI: 10.1021/Acs.Biochem.0C00285  0.369
2020 Tsukamoto T, Gearhart MD, Kim S, Mekonnen G, Spike CA, Greenstein D. Insights into the Involvement of Spliceosomal Mutations in Myelodysplastic Disorders from Analysis of SACY-1/DDX41 in . Genetics. PMID 32060018 DOI: 10.1534/Genetics.119.302973  0.332
2019 Kotov JA, Kotov DI, Linehan JL, Bardwell VJ, Gearhart MD, Jenkins MK. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. The Journal of Experimental Medicine. PMID 31053612 DOI: 10.1084/Jem.20182376  0.359
2019 Kelly MJ, So J, Rogers AJ, Gregory G, Li J, Zethoven M, Gearhart MD, Bardwell VJ, Johnstone RW, Vervoort SJ, Kats LM. Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis. Nature Communications. 10: 1347. PMID 30902969 DOI: 10.1038/S41467-019-09250-6  0.423
2018 Bosnakovski D, Gearhart MD, Toso EA, Ener ET, Choi SH, Kyba M. Low level DUX4 expression disrupts myogenesis through deregulation of myogenic gene expression. Scientific Reports. 8: 16957. PMID 30446688 DOI: 10.1038/S41598-018-35150-8  0.377
2018 Aboudehen K, Farahani S, Kanchwala M, Chan SC, Avdulov S, Mickelson A, Lee D, Gearhart MD, Patel V, Xing C, Igarashi P. Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling. The Journal of Biological Chemistry. PMID 29716997 DOI: 10.1074/Jbc.Ra118.001723  0.333
2018 Wang Z, Gearhart MD, Lee YW, Kumar I, Ramazanov B, Zhang Y, Hernandez C, Lu AY, Neuenkirchen N, Deng J, Jin J, Kluger Y, Neubert TA, Bardwell VJ, Ivanova NB. A Non-canonical BCOR-PRC1.1 Complex Represses Differentiation Programs in Human ESCs. Cell Stem Cell. PMID 29337181 DOI: 10.1016/J.Stem.2017.12.002  0.391
2018 Kawauchi D, Clark J, Okonechnikov K, Batora N, Vouri M, van Rijn S, Gearhart M, Orr B, Korshunov A, Kool M, Bardwell V, Pfister S, Northcott P. MBRS-07. BCOR LOSS IMPACTS SHH MEDULLOBLASTOMA FORMATION VIA TRANSCRIPTIONAL UP-REGULATION OF Igf2 Neuro-Oncology. 20: i129-i130. DOI: 10.1093/Neuonc/Noy059.453  0.313
2017 Bosnakovski D, Gearhart MD, Toso EA, Recht OO, Cucak A, Jain AK, Barton MC, Kyba M. p53-independent DUX4 pathology. Disease Models & Mechanisms. PMID 28754837 DOI: 10.1242/Dmm.030064  0.311
2017 Tsukamoto T, Gearhart MD, Spike CA, Huelgas-Morales G, Mews M, Boag PR, Beilharz TH, Greenstein D. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Genetics. PMID 28576864 DOI: 10.1534/Genetics.117.203174  0.347
2017 Minkina A, Lindeman RE, Gearhart MD, Chassot AA, Chaboissier MC, Ghyselinck NB, Bardwell VJ, Zarkower D. Retinoic acid signaling is dispensable for somatic development and function in the mammalian ovary. Developmental Biology. PMID 28274610 DOI: 10.1016/J.Ydbio.2017.02.015  0.31
2017 Lefebure M, Tothill RW, Kruse E, Hawkins ED, Shortt J, Matthews GM, Gregory GP, Martin BP, Kelly MJ, Todorovski I, Doyle MA, Lupat R, Li J, Schroeder J, Wall M, ... ... Gearhart MD, et al. Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene. Nature Communications. 8: 14581. PMID 28262675 DOI: 10.1038/Ncomms14581  0.345
2016 Wong SJ, Gearhart MD, Taylor AB, Nanyes DR, Ha DJ, Robinson AK, Artigas JA, Lee OJ, Demeler B, Hart PJ, Bardwell VJ, Kim CA. KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1. Structure (London, England : 1993). PMID 27568929 DOI: 10.1016/J.Str.2016.07.011  0.368
2016 Béguelin W, Teater M, Gearhart MD, Calvo Fernández MT, Goldstein RL, Cárdenas MG, Hatzi K, Rosen M, Shen H, Corcoran CM, Hamline MY, Gascoyne RD, Levine RL, Abdel-Wahab O, Licht JD, et al. EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis. Cancer Cell. 30: 197-213. PMID 27505670 DOI: 10.1016/J.Ccell.2016.07.006  0.397
2016 Choi SH, Gearhart MD, Cui Z, Bosnakovski D, Kim M, Schennum N, Kyba M. DUX4 recruits p300/CBP through its C-terminus and induces global H3K27 acetylation changes. Nucleic Acids Research. PMID 26951377 DOI: 10.1093/Nar/Gkw141  0.382
2016 Cao Q, Gearhart MD, Gery S, Shojaee S, Yang H, Sun H, Lin DC, Bai JW, Mead M, Zhao Z, Chen Q, Chien WW, Alkan S, Alpermann T, Haferlach T, et al. BCOR regulates myeloid cell proliferation and differentiation. Leukemia. PMID 26847029 DOI: 10.1038/Leu.2016.2  0.421
2016 Bardwell V, Corcoran C, Gearhart M, Zhang T. Loss of function of the Polycomb repressor complex (PRC1.1) protein, BCOR, in the placenta results in disruption of trophectoderm derived cell fates, IUGR and death Placenta. 45: 80-81. DOI: 10.1016/J.Placenta.2016.06.070  0.322
2015 Gearhart MD, Erickson JR, Walsh A, Echeverri K. Identification of Conserved and Novel MicroRNAs during Tail Regeneration in the Mexican Axolotl. International Journal of Molecular Sciences. 16: 22046-61. PMID 26378530 DOI: 10.3390/Ijms160922046  0.322
2015 Murphy MW, Lee JK, Rojo S, Gearhart MD, Kurahashi K, Banerjee S, Loeuille GA, Bashamboo A, McElreavey K, Zarkower D, Aihara H, Bardwell VJ. An ancient protein-DNA interaction underlying metazoan sex determination. Nature Structural & Molecular Biology. 22: 442-51. PMID 26005864 DOI: 10.1038/Nsmb.3032  0.384
2015 Yang JA, Tubo NJ, Gearhart MD, Bardwell VJ, Jenkins MK. Cutting edge: Bcl6-interacting corepressor contributes to germinal center T follicular helper cell formation and B cell helper function. Journal of Immunology (Baltimore, Md. : 1950). 194: 5604-8. PMID 25964495 DOI: 10.4049/Jimmunol.1500201  0.342
2015 Lindeman RE, Gearhart MD, Minkina A, Krentz AD, Bardwell VJ, Zarkower D. Sexual cell-fate reprogramming in the ovary by DMRT1. Current Biology : Cb. 25: 764-71. PMID 25683803 DOI: 10.1016/J.Cub.2015.01.034  0.343
2014 Zhang T, Murphy MW, Gearhart MD, Bardwell VJ, Zarkower D. The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis. Development (Cambridge, England). 141: 3662-71. PMID 25249458 DOI: 10.1242/Dev.113936  0.375
2014 Lefebure MP, Tothill R, Li J, Matthews G, Shortt J, Hawkins E, Kruse E, Doyle M, Poortinga G, Hannan R, Bardwell V, Gearhart M, Johnstone RW. Abstract 449: Exome sequencing reveals Bcl6 co-repressor (Bcor) as a frequently mutated tumor suppressor gene in Eμ-Myc lymphoma Cancer Research. 74: 449-449. DOI: 10.1158/1538-7445.Am2014-449  0.345
2013 Hatzi K, Jiang Y, Huang C, Garrett-Bakelman F, Gearhart MD, Giannopoulou EG, Zumbo P, Kirouac K, Bhaskara S, Polo JM, Kormaksson M, MacKerell AD, Xue F, Mason CE, Hiebert SW, et al. A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters. Cell Reports. 4: 578-88. PMID 23911289 DOI: 10.1016/J.Celrep.2013.06.016  0.39
2013 Junco SE, Wang R, Gaipa JC, Taylor AB, Schirf V, Gearhart MD, Bardwell VJ, Demeler B, Hart PJ, Kim CA. Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs. Structure (London, England : 1993). 21: 665-71. PMID 23523425 DOI: 10.1016/J.Str.2013.02.013  0.355
2012 Cao Q, Gery S, Shojaee S, Gearhart M, Bardwell V, Muschen M, Koeffler HP. BCOR Is Involved in Myeloid Cell Growth Control by Regulating Hox Genes Blood. 120: 3445-3445. DOI: 10.1182/Blood.V120.21.3445.3445  0.413
2012 Shojaee S, Geng H, Gearhart M, Bardwell V, Muschen M. BCL6 Interacting Corepressor (BCOR) Functions As Lineage-Specific Tumor Suppressor in B Lymphoid and Myeloid Leukemia Blood. 120: 1301-1301. DOI: 10.1182/Blood.V120.21.1301.1301  0.345
2011 Junco SE, Bardwell VJ, Kim CA, Wang R, Robinson A, Ilangovan U, Taylor A, Gearhart MD, Hart PJ, Hinck AP, Borries D. Abstract C28: Binding to BCOR defines a subfamily of Psc ortholog mediated polycomb group complexes Cancer Research. 71. DOI: 10.1158/1538-7445.Fbcr11-C28  0.316
2010 Gearhart M, Holmbeck S, Evans R, Dyson H, Wright P. 1H, 13C, and 15N Chemical shifts for hERR2 Protein, 1H chemical shifts for DNA Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr5363  0.408
2006 Gearhart MD, Corcoran CM, Wamstad JA, Bardwell VJ. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. Molecular and Cellular Biology. 26: 6880-9. PMID 16943429 DOI: 10.1128/Mcb.00630-06  0.393
2005 Gearhart MD, Dickinson L, Ehley J, Melander C, Dervan PB, Wright PE, Gottesfeld JM. Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides. Biochemistry. 44: 4196-203. PMID 15766247 DOI: 10.1021/Bi047872O  0.481
2003 Gearhart MD, Holmbeck SM, Evans RM, Dyson HJ, Wright PE. Monomeric complex of human orphan estrogen related receptor-2 with DNA: a pseudo-dimer interface mediates extended half-site recognition. Journal of Molecular Biology. 327: 819-32. PMID 12654265 DOI: 10.1016/S0022-2836(03)00183-9  0.477
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