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Anthony E. Boitano, Ph.D. - Publications

Affiliations: 
2005 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
anti-DNA autoantibody structure and function, and the identification of novel molecular targets and small molecules for the treatment of autoimmune diseases and cancer
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70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Gustafsson K, Rhee C, Frodermann V, Scadden EW, Li D, Iwamoto Y, Palchaudhuri R, Hyzy S, Boitano A, Nahrendorf M, Scadden DT. Clearing and replacing tissue-resident myeloid cells with an anti-CD45-antibody-drug conjugate. Blood Advances. PMID 37748049 DOI: 10.1182/bloodadvances.2023010561  0.348
2023 Gustafsson K, Rhee C, Frodermann V, Scadden EW, Li D, Iwamoto Y, Palchaudhuri R, Hyzy SL, Boitano AE, Nahrendorf M, Scadden DT. CD45-antibody-drug conjugate clears tissue resident myeloid cells from their niches enabling therapeutic adoptive cell transfer. Biorxiv : the Preprint Server For Biology. PMID 37732224 DOI: 10.1101/2023.09.05.556397  0.355
2020 Srikanthan MA, Humbert O, Haworth KG, Ironside C, Rajawat YS, Blazar BR, Palchaudhuri R, Boitano AE, Cooke MP, Scadden DT, Kiem HP. Effective Multi-lineage Engraftment in a Mouse Model of Fanconi Anemia Using Non-genotoxic Antibody-Based Conditioning. Molecular Therapy. Methods & Clinical Development. 17: 455-464. PMID 32226796 DOI: 10.1016/J.Omtm.2020.02.001  0.448
2020 Lanieri L, Lamothe TL, Miske O, McDonough SM, Sarma GN, Bhattarai P, Latimer K, Dushime J, Jain N, Palchaudhuri R, Knihtila R, Pearse BR, Proctor JL, Boitano AE, Cooke MP, et al. A Single Dose of a Novel Anti-Human CD117-Amanitin Antibody Drug Conjugate (ADC) Engineered for a Short Half-Life Provides Dual Conditioning and Anti-Leukemic Activity and Extends Survival Compared to Standard of Care in Multiple Preclinical Models of Acute Myeloid Leukemia (AML) Blood. 136: 47-48. DOI: 10.1182/blood-2020-140422  0.313
2020 Hyzy SL, Palchaudhuri R, Proctor JL, Pearse BR, Sarma GN, Gillard GO, Saha A, Lamothe TL, Brooks ML, Hammond K, Bhat A, Clark N, McDonagh CF, Kiem H, Wagner JE, ... ... Boitano AE, et al. Successful Allogeneic Hematopoietic Stem Cell Transplantation in Mice Mediated By Well-Tolerated Conditioning Regimens Based on CD45-Targeted Antibody Drug Conjugate: Implications for Haplo Transplantation Biology of Blood and Marrow Transplantation. 26: S160. DOI: 10.1016/J.Bbmt.2019.12.713  0.432
2020 Pearse BR, Proctor JL, McDonough SM, Panwar R, Sarma GN, Neale J, Kien L, Dushime J, Latimer K, Lamothe TL, Brooks ML, Palchaudhuri R, Li Q, Jain N, Knihtila R, ... ... Boitano AE, et al. A Non-Genotoxic Anti-CD117 Antibody Drug Conjugate (ADC) Designed for Patient Conditioning Prior to Stem Cell Transplant and HSC-Based Gene Therapy Has a Broad Therapeutic Window across Species Biology of Blood and Marrow Transplantation. 26: S35-S36. DOI: 10.1016/J.Bbmt.2019.12.580  0.422
2020 Gillard GO, Proctor JL, Brooks ML, Lamothe TL, Hyzy SL, McDonough SM, Clark N, Palchaudhuri R, Bhat A, Sarma GN, Bhattarai PR, Sawant P, Pearse BR, McDonagh CF, Boitano AE, et al. A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT and Ameliorate Disease in Preclinical Autoimmune Disease Models Biology of Blood and Marrow Transplantation. 26: S307-S308. DOI: 10.1016/J.Bbmt.2019.12.407  0.414
2020 Goncalves KA, Hyzy SL, Brooks ML, Hertzler HJ, Boitano AE, Cooke MP. High Dose Hematopoietic Stem Cell Transplantation Leads to Rapid Neural and Peripheral Disease Cross-Correction Via Robust Hematopoietic and Microglia Recovery Biology of Blood and Marrow Transplantation. 26. DOI: 10.1016/J.Bbmt.2019.12.225  0.402
2020 Wagner JE, Brunstein CG, McKenna DH, Sumstad D, Miller JS, Blazar BR, Defor TE, Boitano AE, Cooke MP, Raffel GD, Davis JC, Stefanski H. Mgta-456, a Cell Therapy Utilizing Expansion of CD34+ Hematopoietic Stem Cells (HSC), Improves HLA Matching for Adult Recipients, Promotes Faster Hematopoietic Recovery and Enables Uniform Engraftment with Less Acute Graft-Vs-Host Disease (GVHD) Biology of Blood and Marrow Transplantation. 26: S205-S206. DOI: 10.1016/J.Bbmt.2019.12.222  0.425
2020 Uchida N, Tisdale JF, Donahue RE, Pearse BR, McDonough SM, Proctor JL, Krouse AE, Linde N, Bonifacino A, Panwar R, Sarma GN, Kien L, Latimer K, Dushime J, Hyzy SL, ... ... Boitano AE, et al. A Single Dose of CD117 Antibody Drug Conjugate Enables Hematopoietic Stem Cell Based Gene Therapy in Nonhuman Primates Biology of Blood and Marrow Transplantation. 26: S6. DOI: 10.1016/J.Bbmt.2019.12.139  0.451
2020 DiPersio JF, Devine SM, Hoggatt J, Scadden D, Howell H, Schmelmer V, Neale J, Boitano AE, Cooke MP, Goncalves KA, Raffel GD, Savage W, Falahee PC, Morrow DM, Davis JC. Phase 1 Clinical Study of Mgta-145 in Combination with Plerixafor Shows Rapid Single-Day Mobilization and Collection of CD34+ HSCs without G-CSF Biology of Blood and Marrow Transplantation. 26: S55. DOI: 10.1016/J.Bbmt.2019.12.129  0.425
2020 Orchard PJ, Raffel GD, Condon CEH, Braun JA, Shanley R, Lund TC, Gupta A, Boitano AE, Cooke MP, Davis JC, Wagner JE. Mgta-456 Cell Therapy in Inherited Metabolic Disease (IMD) Yields Rapid and Durable Long-Term Improvement of Disease-Specific Outcomes in a Phase 2 Trial Biology of Blood and Marrow Transplantation. 26. DOI: 10.1016/J.Bbmt.2019.12.084  0.405
2020 Proctor JL, Gillard GO, Mikse O, Lanieri L, Lamothe TL, Brooks ML, Kien L, McDonough SM, Bhat A, Palchaudhuri R, Bhattarai Pr, Sarma GN, Jain N, McDonagh CF, Boitano AE, et al. A Single Dose of a Novel Anti-Human Short Half-Life Engineered CD45-Targeted Antibody-Drug Conjugate (ADC) Is Cytoreductive on Patient-Derived Tumors and Extends Survival Beyond Standards of Care in Multiple Pre-Clinical Models of Hematologic Malignancy Biology of Blood and Marrow Transplantation. 26. DOI: 10.1016/J.Bbmt.2019.12.021  0.431
2019 Goncalves KA, Hoban MD, Hyzy SL, George KS, Boitano AE, Cooke MP. Ex Vivo Expansion with E478 Increases the Rate of CRISPR-Mediated Homology Directed Repair of the Beta-Globin Gene in Human Hematopoietic Stem Cells By >10-Fold and Improves In Vivo Engraftment By >120-Fold Blood. 134: 4634-4634. DOI: 10.1182/Blood-2019-131157  0.467
2019 Gillard GO, Proctor JL, Brooks ML, Lamothe TL, Hyzy SL, Mikse O, McDonough S, Palchaudhuri R, Bhat A, Sarma GN, Bhattarai P, Sawant P, Pearse BR, Mcdonough CF, Boitano AE, et al. A Novel Targeted Approach to Achieve Immune System Reset: CD45-Targeted Antibody Drug Conjugates Enable Autologous HSCT, Ameliorate Disease in Autoimmune Models, Potently Kill Human Immune Cells from Normal Donors and MS Patients, and Achieve Immune Depletion in Non-Human Primates (NHP) Blood. 134: 3208-3208. DOI: 10.1182/Blood-2019-130752  0.416
2019 DiPersio JF, Hoggatt J, Devine S, Biernat L, Howell H, Schmelmer V, Neale JR, Boitano AE, Cooke MP, Goncalves KA, Raffel GD, Falahee PC, Morrow DM, Davis JC. Rapid and Robust Mobilization of CD34+ HSCs without G-CSF Following Administration of Mgta-145 Alone or in Combination with Plerixafor Blood. 134: 1961-1961. DOI: 10.1182/Blood-2019-127523  0.407
2019 Tisdale JF, Donahue RE, Uchida N, Pearse BR, McDonough SM, Proctor JL, Krouse A, Linde NS, Bonifacino AC, Panwar R, Sarma GN, Kien L, Latimer K, Dushime J, Hyzy SL, ... ... Boitano AE, et al. A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates Blood. 134: 610-610. DOI: 10.1182/Blood-2019-125968  0.45
2019 Stefanski H, Brunstein CG, McKenna DH, Sumstad D, Miller JS, Blazar BR, DeFor TE, Boitano AE, Cooke MP, Raffel GD, Davis JC, Wagner JE. Mgta-456, an Aryl Hydrocarbon Receptor (AHR) Antagonist Based Expansion of CD34+ Hematopoietic Stem Cells (HSC), Permits Selection of Better HLA Matched Cord Blood Units (CBUs) and Promotes Faster Neutrophil Recovery and Uniform Engraftment with Potentially Less Acute Graft-Vs-Host Disease (GVHD) Blood. 134: 804-804. DOI: 10.1182/Blood-2019-122329  0.394
2019 Goncalves KA, Hyzy SL, Brooks ML, Hertzler HJ, Boitano AE, Cooke MP. High Dose Hematopoietic Stem Cell Transplantation Leads to Rapid Hematopoietic and Microglia Recovery and Disease Correction in a Mouse Model of Hurler Syndrome Blood. 134: 4424-4424. DOI: 10.1016/J.Ymgme.2019.11.319  0.415
2019 Orchard PJ, Raffel GD, Condon CEH, Monaghan CA, Braun JA, Shanley R, Lund TC, Gupta A, Boitano AE, Cooke M, Davis DC, Wagner JE. Preliminary results demonstrate engraftment with minimal neutropenia with MGTA-456, a CD34+expanded cord blood (CB) product in patients transplanted for inherited metabolic disorders (IMD) Molecular Genetics and Metabolism. 126. DOI: 10.1016/J.Ymgme.2018.12.286  0.414
2019 Goncalves KA, Li S, Brooks ML, Hyzy SL, Boitano AE, Cooke MP. MGTA-456, a first-in-class cell therapy that enables a reduced intensity conditioning regimen and enhances speed and level of human microglia engraftment in the brains of NSG mice Molecular Genetics and Metabolism. 126: S62. DOI: 10.1016/J.Ymgme.2018.12.145  0.313
2019 Hyzy SL, Palchaudhuri R, Proctor JL, Pearse BR, Sarma GN, Adams HL, Aslanian S, Gillard GO, Lamothe TL, Burenkova O, Brooks M, Gabros AD, McDonagh CF, Boitano AE, Cooke MP. CD45-Targeted Antibody Drug Conjugate Plus Post Transplant Cytoxan Is Sufficient to Enable Allogeneic Bone Marrow Transplant in a Minor Mismatch Mouse Model Biology of Blood and Marrow Transplantation. 25. DOI: 10.1016/J.Bbmt.2018.12.775  0.4
2019 Boitano AE, Goncalves KA, Sumstad D, Wagner JE, Cooke MP. Mgta-456 Contains Large Numbers of CD34+CD90+ Hematopoietic Stem Cells (HSC) Which Contain the NSG Engraftment Activity and Correlate with Time to Neutrophil Recovery Following Transplant into Patients with Hematologic Malignancy Biology of Blood and Marrow Transplantation. 25: S2-S3. DOI: 10.1016/J.Bbmt.2018.12.684  0.386
2019 Goncalves KA, Falahee PC, Hyzy SL, Li S, Boitano AE, Morrow DM, Cooke MP. Co-Administration of Mgta-145 and Plerixafor Rapidly Mobilizes High Numbers of Hematopoietic Stem Cells and Graft-Versus-Host Disease Inhibiting Monocytic Cells in Non-Human Primates Biology of Blood and Marrow Transplantation. 25: S291-S292. DOI: 10.1016/J.Bbmt.2018.12.667  0.397
2019 Proctor JL, Hyzy SL, Adams HL, Brooks M, Gabros AD, McDonough SM, Kien L, Aslanian S, Pearse BR, Palchaudhuri R, Li Q, Sarma GN, Ladwig D, Dushime J, Panwar R, ... ... Boitano AE, et al. Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models Biology of Blood and Marrow Transplantation. 25: S100. DOI: 10.1016/J.Bbmt.2018.12.368  0.429
2019 Falahee PC, Goncalves KA, Radtke S, Hyzy SL, Kiem H, Boitano AE, Morrow DM, Cooke MP. Mgta-145 in Combination with Plerixafor Mobilizes Large Numbers of Hematopoietic Stem Cells That Lead to Rapid Engraftment Following Autologous Transplantation in Nonhuman Primates Biology of Blood and Marrow Transplantation. 25: S217-S218. DOI: 10.1016/J.Bbmt.2018.12.298  0.434
2019 Goncalves KA, Li S, Brooks M, Hyzy SL, Boitano AE, Cooke MP. Mgta-456, a First-in-Class Cell Therapy with High Doses of CD34+CD90+ Cells, Enhances Speed and Level of Human Microglia Engraftment in the Brains of NSG Mice Biology of Blood and Marrow Transplantation. 25: S92-S93. DOI: 10.1016/J.Bbmt.2018.12.173  0.484
2019 Orchard PJ, Raffel GD, Condon CE, Monaghan CA, Braun JA, Shanley R, Lund TC, Gupta A, Boitano AE, Cooke MP, Davis JC, Wagner JE. Robust Engraftment with Mgta-456, a CD34+ Expanded Cell Therapy Product in Patients with Inherited Metabolic Disorders (IMD): Preliminary Phase 2 Trial Results Biology of Blood and Marrow Transplantation. 25. DOI: 10.1016/J.Bbmt.2018.12.171  0.412
2019 Palchaudhuri R, Pearse BR, Proctor JL, Hyzy SL, Aslanian S, Bhat A, Gillard GO, McDonough SM, Sarma GN, Ladwig D, Li Q, Jain N, Panwar R, Sawant P, Dushime J, ... ... Boitano AE, et al. Non-Genotoxic Conditioning Using Amanitin Antibody-Drug Conjugates Targeting CD45 Effectively Deplete Human and Non-Human Primate Hematopoietic Stem Cells and Immune Cells Biology of Blood and Marrow Transplantation. 25: S32. DOI: 10.1016/J.Bbmt.2018.12.104  0.447
2019 Pearse BR, McDonough SM, Proctor JL, Panwar R, Sarma GN, Kien L, Dushime J, Adams HL, Hyzy SL, Brooks M, Palchaudhuri R, Li Q, Sawant P, Lamothe TL, Jain N, ... ... Boitano AE, et al. A CD117-Amanitin Antibody Drug Conjugate (ADC) Effectively Depletes Human and Non-Human Primate Hematopoietic Stem and Progenitor Cells (HSPCs): targeted Non-Genotoxic Conditioning for Bone Marrow Transplant Biology of Blood and Marrow Transplantation. 25: S29-S30. DOI: 10.1016/J.Bbmt.2018.12.101  0.432
2018 Ting PY, Parker AE, Lee JS, Trussell C, Sharif O, Luna F, Federe G, Barnes SW, Walker JR, Vance J, Gao MY, Klock HE, Clarkson S, Russ C, Miraglia LJ, ... ... Boitano AE, et al. Guide Swap enables genome-scale pooled CRISPR-Cas9 screening in human primary cells. Nature Methods. PMID 30297964 DOI: 10.1038/S41592-018-0149-1  0.438
2018 Palchaudhuri R, Hyzy SL, Proctor JL, Adams HL, Pearse BR, Sarma G, Aslanian S, Gillard G, Lamothe TL, Burenkova O, Brooks ML, Gabros AD, McDonagh CF, Boitano AE, Cooke MP. Antibody Drug Conjugates Targeted to CD45 or CD117 Enable Allogeneic Hematopoietic Stem Cell Transplantation in Animal Models Blood. 132: 3324-3324. DOI: 10.1182/Blood-2018-99-119432  0.41
2018 Goncalves KA, Li S, Brooks ML, Hyzy SL, Boitano AE, Cooke MP. MGTA-456, a First-in-Class Cell Therapy Produced from a Single Cord Blood Unit, Enables a Reduced Intensity Conditioning Regimen and Enhances Speed and Level of Human Microglia Engraftment in the Brains of NSG Mice Blood. 132: 115-115. DOI: 10.1182/Blood-2018-99-118258  0.449
2018 Goncalves KA, Falahee PC, Hyzy SL, Li S, Boitano AE, Morrow DM, Cooke MP. MGTA-145 in Combination with Plerixafor Rapidly Mobilizes High Numbers of Hematopoietic Stem Cells and Graft-Versus-Host Disease Inhibiting Myeloid-Derived Suppressor Cells in Non-Human Primates Blood. 132: 116-116. DOI: 10.1182/Blood-2018-99-117370  0.428
2018 Palchaudhuri R, Pearse BR, Proctor JL, Hyzy SL, Aslanian S, McDonough SM, Sarma G, Brooks ML, Bhat A, Ladwig D, McShea MA, Kallen NM, Li Q, Panwar R, Dushime J, ... ... Boitano AE, et al. Targeting CD45 with an Amanitin Antibody-Drug Conjugate Effectively Depletes Human HSCs and Immune Cells for Transplant Conditioning Blood. 132: 4526-4526. DOI: 10.1182/Blood-2018-99-117167  0.455
2018 Srikanthan M, Haworth KG, Ironside CM, Chen J, Hartigan AJ, Palchaudhuri R, Boitano AE, Cooke MP, Kiem H. Non-Genotoxic Conditioning Efficiently Depletes Host Hematopoietic Stem Cells and Facilitates Robust Multi-Lineage Engraftment in a Mouse Model of Fanconi Anemia Blood. 132: 2041-2041. DOI: 10.1182/Blood-2018-99-116851  0.453
2018 Orchard P, Raffel GD, Condon CH, Monaghan CA, Vernet D, Sheirr ST, Braun J, Shanley R, Lund TC, Boitano AE, Cooke MP, Davis JC, Wagner JE. Preliminary Phase 2 Results Demonstrate Engraftment with Minimal Neutropenia with MGTA-456, a CD34+ Expanded Cord Blood (CB) Product in Patients Transplanted for Inherited Metabolic Disorders (IMD) Blood. 132: 3467-3467. DOI: 10.1182/Blood-2018-99-115102  0.416
2018 Boitano AE, Cooke MP, Goncalves KA, Sumstad D, Wagner JE. Mgta-456 Contains Large Numbers of Expanded Cord Blood (CB) CD34+CD90+ Hematopoietic Stem Cells (HSC) Which Confer All Engraftment Activity and Correlate with Accelerated Neutrophil Recovery after Myeloablative Conditioning in Patients with Hematologic Malignancy Blood. 132: 2083-2083. DOI: 10.1182/Blood-2018-99-114988  0.425
2018 Pearse BR, McDonough SM, Proctor JL, Panwar R, Sarma G, McShea MA, Kien L, Dushime J, Adams HL, Hyzy SL, Brooks ML, Palchaudhuri R, Li Q, Kallen NM, Sawant P, ... ... Boitano AE, et al. CD117-Amanitin Antibody Drug Conjugates Effectively Deplete Human and Non-Human Primate HSCs: Proof of Concept As a Targeted Strategy for Conditioning Patients for Bone Marrow Transplant Blood. 132: 3314-3314. DOI: 10.1182/Blood-2018-99-114881  0.421
2018 Proctor JL, Hyzy SL, Adams HL, Brooks ML, Gabros AD, McDonough SM, Kien L, Aslanian S, Pearse BR, Palchaudhuri R, Li Q, Kallen NM, Sarma G, McShea MA, Ladwig D, ... ... Boitano AE, et al. Single Doses of Antibody Drug Conjugates (ADCs) Targeted to CD117 or CD45 Have Potent In Vivo Anti-Leukemia Activity and Survival Benefit in Patient Derived AML Models Blood. 132: 3316-3316. DOI: 10.1182/Blood-2018-99-112726  0.426
2018 Hartigan AJ, Pearse BR, McDonough SM, Proctor JL, Adams HL, McShea MA, Hoban MD, Panwar R, Hyzy SL, Goncalves KA, Palchaudhuri R, Boitano AE, Cooke MP. A Non-Genotoxic Antibody Drug Conjugate Targeting C-Kit for Hematopoietic Stem Cell Transplant Conditioning Biology of Blood and Marrow Transplantation. 24: S47-S48. DOI: 10.1016/J.Bbmt.2017.12.598  0.386
2018 Goncalves KA, Hoban MD, Proctor JL, Adams HL, Hyzy SL, Boitano AE, Cooke MP. Phenotype Does not Always Equal Function: HDAC Inhibitors and UM171, but not SR1, Lead to Rapid Upregulation of CD90 on Non-Engrafting CD34+CD90-Negative Human Cells Biology of Blood and Marrow Transplantation. 24: S479. DOI: 10.1016/J.Bbmt.2017.12.576  0.372
2018 Hoban MD, Goncalves KA, Proctor JL, George KS, Adams HL, Hyzy SL, Boitano AE, Cooke MP. Aryl Hydrocarbon Receptor Antagonists Expand Adult Hematopoietic Stem Cells From Mobilized Peripheral Blood and Bone Marrow and Increase the Dose of CRISPR/Cas9 Gene-Edited NSG-Repopulating Cells Biology of Blood and Marrow Transplantation. 24: S477. DOI: 10.1016/J.Bbmt.2017.12.572  0.388
2018 Goncalves KA, Hoban MD, Proctor JL, Hyzy SL, George KS, Boitano AE, Cooke MP. Mgta-456, Cord Blood CD34+ Cells Expanded with an Aryl Hydrocarbon Receptor Antagonist, Enhances Human Microglia Engraftment in the Brains of NSG Mice Biology of Blood and Marrow Transplantation. 24: S115-S116. DOI: 10.1016/J.Bbmt.2017.12.031  0.361
2015 Wagner JE, Brunstein CG, Boitano AE, DeFor TE, McKenna D, Sumstad D, Blazar BR, Tolar J, Le C, Jones J, Cooke MP, Bleul CC. Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft. Cell Stem Cell. PMID 26669897 DOI: 10.1016/J.Stem.2015.10.004  0.44
2014 Wagner JE, Brunstein C, McKenna D, Sumstad D, Maahs S, Laughlin M, Perry MS, Boitano AE, Cooke MP, Bleul CC. StemRegenin-1 (SR1) Expansion Culture Abrogates the Engraftment Barrier Associated with Umbilical Cord Blood Transplantation (UCBT) Blood. 124: 728-728. DOI: 10.1182/Blood.V124.21.728.728  0.434
2013 de Lichtervelde L, Boitano AE, Wang Y, Krastel P, Petersen F, Cooke MP, Schultz PG. Eupalinilide E inhibits erythropoiesis and promotes the expansion of hematopoietic progenitor cells. Acs Chemical Biology. 8: 866-70. PMID 23441826 DOI: 10.1021/Cb4000234  0.773
2013 Brunstein CG, McKenna D, Sumstad D, Maahs S, Boitano AE, Cooke MP, Bleul CC. Safety and Exploratory Efficacy Of Ex Vivo Expanded Umbilical Cord Blood (UCB) Hematopoietic Stem and Progenitor Cells (HSPC) Using Cytokines and Stem-Regenin 1 (SR1): Interim Results Of a Phase 1/2 Dose Escalation Clinical Study Blood. 122: 698-698. DOI: 10.1182/Blood.V122.21.698.698  0.449
2013 He G, Tan L, Wang W, Boitano AE, Vandeven NA, Opipari AW, Liu JR. Abstract 2479: Bz-423: A novel benzodiazephine mitochondrial-targeted drug, cytotoxic to human ovarian cancer cells. Cancer Research. 73: 2479-2479. DOI: 10.1158/1538-7445.Am2013-2479  0.427
2012 de Lichtervelde L, Antal CE, Boitano AE, Wang Y, Krastel P, Petersen F, Newton AC, Cooke MP, Schultz PG. Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation. Chemistry & Biology. 19: 994-1000. PMID 22921066 DOI: 10.1016/J.Chembiol.2012.06.010  0.781
2012 Boitano AE, de Lichtervelde L, Snead JL, Cooke MP, Schultz PG. An image-based screen identifies a small molecule regulator of megakaryopoiesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 14019-23. PMID 22891346 DOI: 10.1073/Pnas.1212545109  0.766
2012 Csaszar E, Kirouac DC, Yu M, Wang W, Qiao W, Cooke MP, Boitano AE, Ito C, Zandstra PW. Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling. Cell Stem Cell. 10: 218-29. PMID 22305571 DOI: 10.1016/J.Stem.2012.01.003  0.468
2011 Smith KJ, Murray IA, Tanos R, Tellew J, Boitano AE, Bisson WH, Kolluri SK, Cooke MP, Perdew GH. Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism. The Journal of Pharmacology and Experimental Therapeutics. 338: 318-27. PMID 21493753 DOI: 10.1124/Jpet.110.178392  0.328
2011 Bouchez LC, Boitano AE, de Lichtervelde L, Romeo R, Cooke MP, Schultz PG. Small-molecule regulators of human stem cell self-renewal. Chembiochem : a European Journal of Chemical Biology. 12: 854-7. PMID 21381174 DOI: 10.1002/Cbic.201000734  0.746
2011 Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. Chemical control of stem cell fate and developmental potential. Angewandte Chemie (International Ed. in English). 50: 200-42. PMID 21184400 DOI: 10.1002/Anie.201004284  0.484
2011 Cooke MP, Boitano AE. Small Molecule Screens for Stem Cell Expansion Blood. 118: SCI-42-SCI-42. DOI: 10.1182/Blood.V118.21.Sci-42.Sci-42  0.492
2011 Boitano AE. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells (Science (2010) (1345)) Science. 332: 664. DOI: 10.1126/science.332.6030.664-b  0.3
2010 Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, Schultz PG, Cooke MP. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science (New York, N.Y.). 329: 1345-8. PMID 20688981 DOI: 10.1126/Science.1191536  0.422
2010 Garg G, Liu R, Boitano A, Tan L, Kwok R, Glick G, Opipari A. Abstract 4143: Bz-423, a novel benzodiazpine, inhibits PI3 kinase signaling in ovarian cancer cells Cancer Research. 70: 4143-4143. DOI: 10.1158/1538-7445.Am10-4143  0.655
2009 Blatt NB, Boitano AE, Lyssiotis CA, Opipari AW, Glick GD. Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochemical Pharmacology. 78: 966-73. PMID 19481066 DOI: 10.1016/J.Bcp.2009.05.025  0.771
2008 Blatt NB, Boitano AE, Lyssiotis CA, Opipari AW, Glick GD. Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax. Free Radical Biology & Medicine. 45: 1232-42. PMID 18718527 DOI: 10.1016/J.Freeradbiomed.2008.07.022  0.769
2008 Boitano AE, Schultz PG, Cooke M. Self-Renewal of Hematopoietic Stem Cells by a Small Molecule Blood. 112: 210-210. DOI: 10.1182/Blood.V112.11.210.210  0.509
2005 Johnson KM, Chen X, Boitano A, Swenson L, Opipari AW, Glick GD. Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423. Chemistry & Biology. 12: 485-96. PMID 15850986 DOI: 10.1016/J.Chembiol.2005.02.012  0.714
2005 Varani J, Bhagavathula N, Nerusu KC, Sherzer H, Fay K, Boitano AE, Glick GD, Johnson K, Kang S, Opipari AW. A novel benzodiazepine selectively inhibits keratinocyte proliferation and reduces retinoid-induced epidermal hyperplasia in organ-cultured human skin. The Journal of Pharmacology and Experimental Therapeutics. 313: 56-63. PMID 15576471 DOI: 10.1124/Jpet.104.075929  0.608
2004 Bednarski JJ, Lyssiotis CA, Roush R, Boitano AE, Glick GD, Opipari AW. A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis. The Journal of Biological Chemistry. 279: 29615-21. PMID 15123639 DOI: 10.1074/Jbc.M403507200  0.753
2004 Opipari AW, Tan L, Boitano AE, Sorenson DR, Aurora A, Liu JR. Resveratrol-induced autophagocytosis in ovarian cancer cells. Cancer Research. 64: 696-703. PMID 14744787 DOI: 10.1158/0008-5472.Can-03-2404  0.442
2003 Boitano A, Ellman JA, Glick GD, Opipari AW. The proapoptotic benzodiazepine Bz-423 affects the growth and survival of malignant B cells. Cancer Research. 63: 6870-6. PMID 14583485  0.629
2003 Boitano A, Emal CD, Leonetti F, Blatt NB, Dineen TA, Ellman JA, Roush WR, Opipari AW, Glick GD. Structure activity studies of a novel cytotoxic benzodiazepine. Bioorganic & Medicinal Chemistry Letters. 13: 3327-30. PMID 12951119 DOI: 10.1016/S0960-894X(03)00683-8  0.745
2002 Blatt NB, Bednarski JJ, Warner RE, Leonetti F, Johnson KM, Boitano A, Yung R, Richardson BC, Johnson KJ, Ellman JA, Opipari AW, Glick GD. Benzodiazepine-induced superoxide signals B cell apoptosis: mechanistic insight and potential therapeutic utility. The Journal of Clinical Investigation. 110: 1123-32. PMID 12393848 DOI: 10.1172/Jci16029  0.751
2002 Bian X, Opipari AW, Ratanaproeksa AB, Boitano AE, Lucas PC, Castle VP. Constitutively active NFkappa B is required for the survival of S-type neuroblastoma. The Journal of Biological Chemistry. 277: 42144-50. PMID 12198114 DOI: 10.1074/Jbc.M203891200  0.413
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