| Year |
Citation |
Score |
| 2024 |
Padron A, Dwivedi R, Chakraborty R, Prakash P, Kim K, Shi J, Ahn J, Pandhare J, Luban J, Aiken C, Balasubramaniam M, Dash C. Cyclophilin A facilitates HIV-1 integration. Journal of Virology. e0094724. PMID 39480090 DOI: 10.1128/jvi.00947-24 |
0.564 |
|
| 2024 |
Wu C, Meuser ME, Rey JS, Meshkin H, Yang R, Devarkar SC, Freniere C, Shi J, Aiken C, Perilla JR, Xiong Y. Structural insights into inhibitor mechanisms on immature HIV-1 Gag lattice revealed by high-resolution single-particle cryo-EM. Biorxiv : the Preprint Server For Biology. PMID 39416065 DOI: 10.1101/2024.10.09.617473 |
0.585 |
|
| 2024 |
Deshpande A, Bryer AJ, Andino-Moncada JR, Shi J, Hong J, Torres C, Harel S, Francis AC, Perilla JR, Aiken C, Rousso I. Elasticity of the HIV-1 core facilitates nuclear entry and infection. Plos Pathogens. 20: e1012537. PMID 39259747 DOI: 10.1371/journal.ppat.1012537 |
0.657 |
|
| 2024 |
Jennings J, Bracey H, Hong J, Nguyen DT, Dasgupta R, Rivera AV, Sluis-Cremer N, Shi J, Aiken C. The HIV-1 capsid serves as a nanoscale reaction vessel for reverse transcription. Plos Pathogens. 20: e1011810. PMID 39226318 DOI: 10.1371/journal.ppat.1011810 |
0.645 |
|
| 2024 |
Padron A, Dwivedi R, Chakraborty R, Prakash P, Kim K, Shi J, Ahn J, Pandhare J, Luban J, Aiken C, Balasubramaniam M, Dash C. Cyclophilin A Facilitates HIV-1 DNA Integration. Biorxiv : the Preprint Server For Biology. PMID 38948800 DOI: 10.1101/2024.06.15.599180 |
0.585 |
|
| 2024 |
Biswas B, Lai KK, Bracey H, Datta SAK, Harvin D, Sowd GA, Aiken C, Rein A. Essential functions of inositol hexakisphosphate (IP6) in murine leukemia virus replication. Mbio. e0115824. PMID 38912776 DOI: 10.1128/mbio.01158-24 |
0.695 |
|
| 2024 |
Biswas B, Lai KK, Bracey H, Datta SAK, Harvin D, Sowd GA, Aiken C, Rein A. Essential functions of Inositol hexakisphosphate (IP6) in Murine Leukemia Virus replication. Biorxiv : the Preprint Server For Biology. PMID 38464197 DOI: 10.1101/2024.02.27.581940 |
0.635 |
|
| 2023 |
Jennings J, Bracey H, Nguyen DT, Dasgupta R, Rivera AV, Sluis-Cremer N, Shi J, Aiken C. The HIV-1 capsid serves as a nanoscale reaction vessel for reverse transcription. Biorxiv : the Preprint Server For Biology. PMID 37986899 DOI: 10.1101/2023.11.08.566350 |
0.645 |
|
| 2023 |
Deshpande A, Bryer AJ, Andino J, Shi J, Hong J, Torres C, Harel S, Francis AC, Perilla JR, Aiken C, Rousso I. Elasticity of the HIV-1 Core Facilitates Nuclear Entry and Infection. Biorxiv : the Preprint Server For Biology. PMID 37808653 DOI: 10.1101/2023.09.29.560083 |
0.64 |
|
| 2023 |
Gres AT, Kirby KA, McFadden WM, Du H, Liu D, Xu C, Bryer AJ, Perilla JR, Shi J, Aiken C, Fu X, Zhang P, Francis AC, Melikyan GB, Sarafianos SG. Multidisciplinary studies with mutated HIV-1 capsid proteins reveal structural mechanisms of lattice stabilization. Nature Communications. 14: 5614. PMID 37699872 DOI: 10.1038/s41467-023-41197-7 |
0.402 |
|
| 2023 |
Badieyan S, Lichon D, Andreas MP, Gillies JP, Peng W, Shi J, DeSantis ME, Aiken CR, Böcking T, Giessen TW, Campbell EM, Cianfrocco MA. HIV-1 binds dynein directly to hijack microtubule transport machinery. Biorxiv : the Preprint Server For Biology. PMID 37693451 DOI: 10.1101/2023.08.29.555335 |
0.56 |
|
| 2023 |
Sowd GA, Shi J, Fulmer A, Aiken C. HIV-1 capsid stability enables inositol phosphate-independent infection of target cells and promotes integration into genes. Plos Pathogens. 19: e1011423. PMID 37267431 DOI: 10.1371/journal.ppat.1011423 |
0.532 |
|
| 2023 |
Shen Q, Kumari S, Xu C, Jang S, Shi J, Burdick RC, Levintov L, Xiong Q, Wu C, Devarkar SC, Tian T, Tripler TN, Hu Y, Yuan S, Temple J, ... ... Aiken C, et al. The capsid lattice engages a bipartite NUP153 motif to mediate nuclear entry of HIV-1 cores. Proceedings of the National Academy of Sciences of the United States of America. 120: e2202815120. PMID 36943880 DOI: 10.1073/pnas.2202815120 |
0.631 |
|
| 2023 |
Shen Q, Feng Q, Wu C, Xiong Q, Tian T, Yuan S, Shi J, Bedwell GJ, Yang R, Aiken C, Engelman AN, Lusk CP, Lin C, Xiong Y. Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels. Nature Structural & Molecular Biology. PMID 36807645 DOI: 10.1038/s41594-023-00925-9 |
0.582 |
|
| 2022 |
Francis AC, Cereseto A, Singh PK, Shi J, Poeschla E, Engelman AN, Aiken C, Melikyan GB. Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles. Plos Pathogens. 18: e1010754. PMID 35951676 DOI: 10.1371/journal.ppat.1010754 |
0.562 |
|
| 2022 |
Balasubramaniam M, Davids BO, Bryer A, Xu C, Thapa S, Shi J, Aiken C, Pandhare J, Perilla JR, Dash C. HIV-1 mutants that escape the cytotoxic T-lymphocytes are defective in viral DNA integration. Pnas Nexus. 1: pgac064. PMID 35719891 DOI: 10.1093/pnasnexus/pgac064 |
0.671 |
|
| 2021 |
Sowd GA, Shi J, Aiken C. HIV-1 CA Inhibitors Are Antagonized by Inositol Phosphate Stabilization of the Viral Capsid in Cells. Journal of Virology. 95: e0144521. PMID 34613803 DOI: 10.1128/JVI.01445-21 |
0.635 |
|
| 2021 |
Aiken C, Rousso I. The HIV-1 capsid and reverse transcription. Retrovirology. 18: 29. PMID 34563203 DOI: 10.1186/s12977-021-00566-0 |
0.574 |
|
| 2021 |
Mendonça L, Sun D, Ning J, Liu J, Kotecha A, Olek M, Frosio T, Fu X, Himes BA, Kleinpeter AB, Freed EO, Zhou J, Aiken C, Zhang P. CryoET structures of immature HIV Gag reveal six-helix bundle. Communications Biology. 4: 481. PMID 33863979 DOI: 10.1038/s42003-021-01999-1 |
0.581 |
|
| 2021 |
Rankovic S, Deshpande A, Harel S, Aiken C, Rousso I. HIV-1 uncoating occurs via a series of rapid biomechanical changes in the core related to individual stages of reverse transcription. Journal of Virology. PMID 33692202 DOI: 10.1128/JVI.00166-21 |
0.527 |
|
| 2021 |
Sowd GA, Aiken C. Correction: Inositol phosphates promote HIV-1 assembly and maturation to facilitate viral spread in human CD4+ T cells. Plos Pathogens. 17: e1009389. PMID 33651846 DOI: 10.1371/journal.ppat.1009389 |
0.473 |
|
| 2021 |
Sowd GA, Aiken C. Inositol phosphates promote HIV-1 assembly and maturation to facilitate viral spread in human CD4+ T cells. Plos Pathogens. 17: e1009190. PMID 33476323 DOI: 10.1371/journal.ppat.1009190 |
0.662 |
|
| 2020 |
Xu C, Fischer DK, Rankovic S, Li W, Dick RA, Runge B, Zadorozhnyi R, Ahn J, Aiken C, Polenova T, Engelman AN, Ambrose Z, Rousso I, Perilla JR. Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis. Plos Biology. 18: e3001015. PMID 33332391 DOI: 10.1371/journal.pbio.3001015 |
0.586 |
|
| 2020 |
Jennings J, Shi J, Varadarajan J, Jamieson PJ, Aiken C. The Host Cell Metabolite Inositol Hexakisphosphate Promotes Efficient Endogenous HIV-1 Reverse Transcription by Stabilizing the Viral Capsid. Mbio. 11. PMID 33262260 DOI: 10.1128/mBio.02820-20 |
0.643 |
|
| 2020 |
Featherstone A, Aiken C. SERINC5 Inhibits HIV-1 Infectivity by Altering the Conformation of gp120 on HIV-1 Particles. Journal of Virology. PMID 32796070 DOI: 10.1128/Jvi.00594-20 |
0.734 |
|
| 2020 |
Ni T, Gerard S, Zhao G, Dent K, Ning J, Zhou J, Shi J, Anderson-Daniels J, Li W, Jang S, Engelman AN, Aiken C, Zhang P. Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A. Nature Structural & Molecular Biology. PMID 32747784 DOI: 10.1038/S41594-020-0467-8 |
0.426 |
|
| 2020 |
Aiken C. Shielding the HIV-1 capsid. Nature Microbiology. 5: 12-13. PMID 31857731 DOI: 10.1038/S41564-019-0638-8 |
0.706 |
|
| 2019 |
Anderson-Daniels J, Singh PK, Sowd GA, Li W, Engelman AN, Aiken C. Dominant negative MA-CA fusion protein is incorporated into HIV-1 cores and inhibits nuclear entry of viral preintegration complexes. Journal of Virology. PMID 31413124 DOI: 10.1128/Jvi.01118-19 |
0.665 |
|
| 2019 |
Siddiqui MA, Saito A, Halambage UD, Ferhadian D, Fischer DK, Francis AC, Melikyan GB, Ambrose Z, Aiken C, Yamashita M. A novel phenotype links HIV-1 capsid stability to cGAS-mediated DNA sensing. Journal of Virology. PMID 31167922 DOI: 10.1128/Jvi.00706-19 |
0.51 |
|
| 2019 |
Peng W, Shi J, Márquez CL, Lau D, Walsh J, Faysal KMR, Byeon CH, Byeon IL, Aiken C, Böcking T. Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A. Retrovirology. 16: 10. PMID 30947724 DOI: 10.1186/S12977-019-0471-4 |
0.544 |
|
| 2019 |
Carnes SK, Aiken C. Host proteins involved in microtubule-dependent HIV-1 intracellular transport and uncoating Future Virology. 14: 361-374. DOI: 10.2217/Fvl-2019-0004 |
0.581 |
|
| 2018 |
Balasubramaniam M, Zhou J, Addai A, Martinez P, Pandhare J, Aiken C, Dash C. PF74 Inhibits HIV-1 Integration by Altering The Composition of the Preintegration Complex. Journal of Virology. PMID 30567984 DOI: 10.1128/Jvi.01741-18 |
0.65 |
|
| 2018 |
Rankovic S, Ramalho R, Aiken C, Rousso I. PF74 reinforces the HIV-1 capsid to impair reverse transcription-induced uncoating. Journal of Virology. PMID 30089694 DOI: 10.1128/Jvi.00845-18 |
0.714 |
|
| 2018 |
Carnes SK, Zhou J, Aiken C. HIV-1 Engages a Dynein-Dynactin-BICD2 Complex for Infection and Transport to the Nucleus. Journal of Virology. PMID 30068656 DOI: 10.1128/Jvi.00358-18 |
0.687 |
|
| 2018 |
Carnes SK, Sheehan JH, Aiken C. Inhibitors of the HIV-1 capsid, a target of opportunity. Current Opinion in Hiv and Aids. PMID 29782334 DOI: 10.1097/Coh.0000000000000472 |
0.598 |
|
| 2017 |
Wang M, Quinn CM, Perilla JR, Zhang H, Shirra R, Hou G, Byeon IJ, Suiter CL, Ablan S, Urano E, Nitz TJ, Aiken C, Freed EO, Zhang P, Schulten K, et al. Quenching protein dynamics interferes with HIV capsid maturation. Nature Communications. 8: 1779. PMID 29176596 DOI: 10.1038/S41467-017-01856-Y |
0.544 |
|
| 2017 |
Burse M, Shi J, Aiken C. Cyclophilin A potentiates TRIM5α inhibition of HIV-1 nuclear import without promoting TRIM5α binding to the viral capsid. Plos One. 12: e0182298. PMID 28767697 DOI: 10.1371/Journal.Pone.0182298 |
0.693 |
|
| 2017 |
Rankovic S, Varadarajan J, Ramalho R, Aiken C, Rousso I. Reverse transcription mechanically initiates HIV-1 capsid disassembly. Journal of Virology. PMID 28381579 DOI: 10.1128/Jvi.00289-17 |
0.629 |
|
| 2017 |
Wang W, Zhou J, Halambage UD, Jurado KA, Jamin AV, Wang Y, Engelman AN, Aiken C. Inhibition of HIV-1 Maturation via Small-Molecule Targeting of the Amino-Terminal Domain in the Viral Capsid Protein. Journal of Virology. 91. PMID 28202766 DOI: 10.1128/Jvi.02155-16 |
0.728 |
|
| 2016 |
Ning J, Erdemci-Tandogan G, Yufenyuy EL, Wagner J, Himes BA, Zhao G, Aiken C, Zandi R, Zhang P. In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway. Nature Communications. 7: 13689. PMID 27958264 DOI: 10.1038/Ncomms13689 |
0.659 |
|
| 2016 |
Matei E, Basu R, Furey W, Shi J, Calnan C, Aiken C, Gronenborn AM. Structure and Glycan Binding of a New Cyanovirin-N Homolog. The Journal of Biological Chemistry. PMID 27402833 DOI: 10.1074/Jbc.M116.740415 |
0.59 |
|
| 2016 |
Francis AC, Marin M, Shi J, Aiken C, Melikyan GB. Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells. Plos Pathogens. 12: e1005709. PMID 27322072 DOI: 10.1371/Journal.Ppat.1005709 |
0.687 |
|
| 2016 |
Saito A, Ferhadian D, Sowd GA, Serrao E, Shi J, Halambage UD, Teng S, Soto J, Siddiqui MA, Engelman AN, Aiken C, Yamashita M. Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74. Journal of Virology. 90: 5808-5823. PMID 27076642 DOI: 10.1128/Jvi.03116-15 |
0.559 |
|
| 2016 |
Ramalho R, Rankovic S, Zhou J, Aiken C, Rousso I. Analysis of the mechanical properties of wild type and hyperstable mutants of the HIV-1 capsid. Retrovirology. 13: 17. PMID 26979152 DOI: 10.1186/S12977-016-0250-4 |
0.707 |
|
| 2016 |
Liu C, Perilla JR, Ning J, Lu M, Hou G, Ramalho R, Himes BA, Zhao G, Bedwell GJ, Byeon IJ, Ahn J, Gronenborn AM, Prevelige PE, Rousso I, Aiken C, et al. Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site. Nature Communications. 7: 10714. PMID 26940118 DOI: 10.1038/Ncomms10714 |
0.7 |
|
| 2015 |
Lu M, Hou G, Zhang H, Suiter CL, Ahn J, Byeon IL, Perilla JR, Langmead CJ, Hung I, Gor'kov PL, Gan Z, Brey W, Aiken C, Zhang P, Schulten K, et al. Dynamic allostery governs cyclophilin A-HIV capsid interplay. Proceedings of the National Academy of Sciences of the United States of America. PMID 26553990 DOI: 10.1073/Pnas.1516920112 |
0.594 |
|
| 2015 |
Desai TM, Marin M, Sood C, Shi J, Nawaz F, Aiken C, Melikyan GB. Fluorescent protein-tagged Vpr dissociates from HIV-1 core after viral fusion and rapidly enters the cell nucleus. Retrovirology. 12: 88. PMID 26511606 DOI: 10.1186/S12977-015-0215-Z |
0.68 |
|
| 2015 |
Aiken C. HIV: Antiviral action countered by Nef. Nature. 526: 202-3. PMID 26416750 DOI: 10.1038/Nature15637 |
0.701 |
|
| 2015 |
Zhou J, Price AJ, Halambage UD, James LC, Aiken C. HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry. Journal of Virology. PMID 26109731 DOI: 10.1128/Jvi.00340-15 |
0.729 |
|
| 2015 |
Halambage UD, Wong JP, Melancon BJ, Lindsley CW, Aiken C. A Microplate-Based Assay for Identifying Small Molecules that Bind a Specific Intersubunit Interface Within the Assembled HIV-1 Capsid. Antimicrobial Agents and Chemotherapy. PMID 26077250 DOI: 10.1128/Aac.00646-15 |
0.643 |
|
| 2015 |
Shi J, Zhou J, Halambage UD, Shah VB, Burse MJ, Wu H, Blair WS, Butler SL, Aiken C. Compensatory substitutions in the HIV-1 capsid reduce the fitness cost associated with resistance to a capsid-targeting small-molecule inhibitor. Journal of Virology. 89: 208-19. PMID 25320302 DOI: 10.1128/Jvi.01411-14 |
0.692 |
|
| 2015 |
Zhang P, Liu C, Perilla JR, Byeon I, Ning J, Ahn J, Aiken C, Gronenborn AM, Polenova T, Schulten K. Cyclophilin a Stabilizes the Mature HIV-1 Capsid through a Novel Non-Canonical Binding Site Biophysical Journal. 108: 190a. DOI: 10.1016/J.Bpj.2014.11.1051 |
0.59 |
|
| 2014 |
Price AJ, Jacques DA, McEwan WA, Fletcher AJ, Essig S, Chin JW, Halambage UD, Aiken C, James LC. Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly. Plos Pathogens. 10: e1004459. PMID 25356722 DOI: 10.1371/Journal.Ppat.1004459 |
0.536 |
|
| 2014 |
Fribourgh JL, Nguyen HC, Matreyek KA, Alvarez FJD, Summers BJ, Dewdney TG, Aiken C, Zhang P, Engelman A, Xiong Y. Structural insight into HIV-1 restriction by MxB. Cell Host & Microbe. 16: 627-638. PMID 25312384 DOI: 10.1016/J.Chom.2014.09.021 |
0.708 |
|
| 2014 |
Shah VB, Aiken C. Gene expression analysis of a panel of cell lines that differentially restrict HIV-1 CA mutants infection in a cyclophilin a-dependent manner. Plos One. 9: e92724. PMID 24663101 DOI: 10.1371/Journal.Pone.0092724 |
0.633 |
|
| 2014 |
Ambrose Z, Aiken C. HIV-1 uncoating: connection to nuclear entry and regulation by host proteins. Virology. 454: 371-9. PMID 24559861 DOI: 10.1016/J.Virol.2014.02.004 |
0.616 |
|
| 2014 |
Henning MS, Dubose BN, Burse MJ, Aiken C, Yamashita M. In vivo functions of CPSF6 for HIV-1 as revealed by HIV-1 capsid evolution in HLA-B27-positive subjects. Plos Pathogens. 10: e1003868. PMID 24415937 DOI: 10.1371/Journal.Ppat.1003868 |
0.701 |
|
| 2014 |
Price A, Jacques D, Essig S, Elliott T, Halambage U, Chin J, Aiken C, James L. HIV-1 capsid binds host cofactors to mediate nuclear import Acta Crystallographica Section a Foundations and Advances. 70: C120-C120. DOI: 10.1107/S2053273314098799 |
0.603 |
|
| 2013 |
Shah VB, Aiken C. Cell Fractionation and Quantitative Analysis of HIV-1 Reverse Transcription in Target Cells. Bio-Protocol. 3. PMID 27547785 |
0.615 |
|
| 2013 |
Xu H, Franks T, Gibson G, Huber K, Rahm N, De Castillia CS, Luban J, Aiken C, Watkins S, Sluis-Cremer N, Ambrose Z. Evidence for biphasic uncoating during HIV-1 infection from a novel imaging assay. Retrovirology. 10: 70. PMID 23835323 DOI: 10.1186/1742-4690-10-70 |
0.653 |
|
| 2013 |
Lamorte L, Titolo S, Lemke CT, Goudreau N, Mercier JF, Wardrop E, Shah VB, von Schwedler UK, Langelier C, Banik SS, Aiken C, Sundquist WI, Mason SW. Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes. Antimicrobial Agents and Chemotherapy. 57: 4622-31. PMID 23817385 DOI: 10.1128/Aac.00985-13 |
0.546 |
|
| 2013 |
Mathew S, Nguyen M, Wu X, Pal A, Shah VB, Prasad VR, Aiken C, Kalpana GV. INI1/hSNF5-interaction defective HIV-1 IN mutants exhibit impaired particle morphology, reverse transcription and integration in vivo. Retrovirology. 10: 66. PMID 23799881 DOI: 10.1186/1742-4690-10-66 |
0.628 |
|
| 2013 |
Shi J, Friedman DB, Aiken C. Retrovirus restriction by TRIM5 proteins requires recognition of only a small fraction of viral capsid subunits. Journal of Virology. 87: 9271-8. PMID 23785198 DOI: 10.1128/Jvi.00713-13 |
0.605 |
|
| 2013 |
Zhao G, Perilla JR, Yufenyuy EL, Meng X, Chen B, Ning J, Ahn J, Gronenborn AM, Schulten K, Aiken C, Zhang P. Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics. Nature. 497: 643-6. PMID 23719463 DOI: 10.1038/Nature12162 |
0.576 |
|
| 2013 |
Yufenyuy EL, Aiken C. The NTD-CTD intersubunit interface plays a critical role in assembly and stabilization of the HIV-1 capsid. Retrovirology. 10: 29. PMID 23497318 DOI: 10.1186/1742-4690-10-29 |
0.641 |
|
| 2013 |
Shah VB, Shi J, Hout DR, Oztop I, Krishnan L, Ahn J, Shotwell MS, Engelman A, Aiken C. The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating. Journal of Virology. 87: 422-32. PMID 23097435 DOI: 10.1128/Jvi.07177-11 |
0.74 |
|
| 2013 |
Yu Z, Dobro MJ, Woodward CL, Levandovsky A, Danielson CM, Sandrin V, Shi J, Aiken C, Zandi R, Hope TJ, Jensen GJ. Unclosed HIV-1 capsids suggest a curled sheet model of assembly. Journal of Molecular Biology. 425: 112-23. PMID 23079241 DOI: 10.1016/J.Jmb.2012.10.006 |
0.688 |
|
| 2013 |
Aiken C, Zhang P. HIV-1 maturation Advances in Hiv-1 Assembly and Release. 153-166. DOI: 10.1007/978-1-4614-7729-7_6 |
0.673 |
|
| 2012 |
Yang H, Ji X, Zhao G, Ning J, Zhao Q, Aiken C, Gronenborn AM, Zhang P, Xiong Y. Structural insight into HIV-1 capsid recognition by rhesus TRIM5α Proceedings of the National Academy of Sciences of the United States of America. 109: 18372-18377. PMID 23091002 DOI: 10.1073/Pnas.1210903109 |
0.607 |
|
| 2012 |
Meng X, Zhao G, Yufenyuy E, Ke D, Ning J, DeLucia M, Ahn J, Gronenborn AM, Aiken C, Zhang P. Protease Cleavage Leads to Formation of Mature Trimer Interface in HIV-1 Capsid Plos Pathogens. 8. PMID 22927821 DOI: 10.1371/Journal.Ppat.1002886 |
0.586 |
|
| 2012 |
Yang R, Shi J, Byeon IJ, Ahn J, Sheehan JH, Meiler J, Gronenborn AM, Aiken C. Second-site suppressors of HIV-1 capsid mutations: restoration of intracellular activities without correction of intrinsic capsid stability defects. Retrovirology. 9: 30. PMID 22515365 DOI: 10.1186/1742-4690-9-30 |
0.715 |
|
| 2012 |
Roa A, Hayashi F, Yang Y, Lienlaf M, Zhou J, Shi J, Watanabe S, Kigawa T, Yokoyama S, Aiken C, Diaz-Griffero F. RING domain mutations uncouple TRIM5α restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating. Journal of Virology. 86: 1717-27. PMID 22114335 DOI: 10.1128/Jvi.05811-11 |
0.677 |
|
| 2011 |
Shah VB, Aiken C. In vitro uncoating of HIV-1 cores. Journal of Visualized Experiments : Jove. PMID 22105356 DOI: 10.3791/3384 |
0.734 |
|
| 2011 |
Joyner AS, Willis JR, Crowe JE, Aiken C. Maturation-induced cloaking of neutralization epitopes on HIV-1 particles. Plos Pathogens. 7: e1002234. PMID 21931551 DOI: 10.1371/Journal.Ppat.1002234 |
0.638 |
|
| 2011 |
Aiken C, Joyce S. Immunology: TRIM5 does double duty. Nature. 472: 305-6. PMID 21512569 DOI: 10.1038/472305A |
0.329 |
|
| 2011 |
Zhao G, Ke D, Vu T, Ahn J, Shah VB, Yang R, Aiken C, Charlton LM, Gronenborn AM, Zhang P. Rhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfaces Plos Pathogens. 7. PMID 21455494 DOI: 10.1371/Journal.Ppat.1002009 |
0.786 |
|
| 2011 |
Du S, Betts L, Yang R, Shi H, Concel J, Ahn J, Aiken C, Zhang P, Yeh JI. Structure of the HIV-1 full-length capsid protein in a conformationally trapped unassembled state induced by small-molecule binding. Journal of Molecular Biology. 406: 371-86. PMID 21146540 DOI: 10.1016/J.Jmb.2010.11.027 |
0.665 |
|
| 2011 |
Shi J, Zhou J, Shah VB, Aiken C, Whitby K. Small-molecule inhibition of human immunodeficiency virus type 1 infection by virus capsid destabilization. Journal of Virology. 85: 542-9. PMID 20962083 DOI: 10.1128/Jvi.01406-10 |
0.765 |
|
| 2011 |
Zhao G, Meng X, Ke D, Vu T, Ahn J, Shah V, Yang R, Aiken C, Charlton L, Gronenborn A, Zhang P. Structure of HIV Capsid and Interactions with Rhesus TRIM5α Microscopy and Microanalysis. 17: 104-105. DOI: 10.1017/S1431927611001395 |
0.724 |
|
| 2010 |
Shah VB, Aiken C. HIV Nuclear Entry: Clearing the Fog. Viruses. 2: 1190-4. PMID 21994675 DOI: 10.3390/V2051190 |
0.666 |
|
| 2010 |
Black LR, Aiken C. TRIM5alpha disrupts the structure of assembled HIV-1 capsid complexes in vitro. Journal of Virology. 84: 6564-9. PMID 20410272 DOI: 10.1128/Jvi.00210-10 |
0.689 |
|
| 2010 |
Matei E, Zheng A, Furey W, Rose J, Aiken C, Gronenborn AM. Anti-HIV activity of defective cyanovirin-N mutants is restored by dimerization Journal of Biological Chemistry. 285: 13057-13065. PMID 20147291 DOI: 10.1074/Jbc.M109.094938 |
0.54 |
|
| 2009 |
Byeon IJL, Meng X, Jung J, Zhao G, Yang R, Ahn J, Shi J, Concel J, Aiken C, Zhang P, Gronenborn AM. Structural Convergence between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function Cell. 139: 780-790. PMID 19914170 DOI: 10.1016/J.Cell.2009.10.010 |
0.665 |
|
| 2009 |
Aiken C. Cell-free assays for HIV-1 uncoating. Methods in Molecular Biology (Clifton, N.J.). 485: 41-53. PMID 19020817 DOI: 10.1007/978-1-59745-170-3_4 |
0.699 |
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| 2008 |
Qi M, Yang R, Aiken C. Cyclophilin A-dependent restriction of human immunodeficiency virus type 1 capsid mutants for infection of nondividing cells. Journal of Virology. 82: 12001-8. PMID 18829762 DOI: 10.1128/Jvi.01518-08 |
0.759 |
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| 2008 |
Langelier CR, Sandrin V, Eckert DM, Christensen DE, Chandrasekaran V, Alam SL, Aiken C, Olsen JC, Kar AK, Sodroski JG, Sundquist WI. Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication. Journal of Virology. 82: 11682-94. PMID 18799573 DOI: 10.1128/Jvi.01562-08 |
0.514 |
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| 2008 |
Rold CJ, Aiken C. Proteasomal degradation of TRIM5alpha during retrovirus restriction. Plos Pathogens. 4: e1000074. PMID 18497858 DOI: 10.1371/Journal.Ppat.1000074 |
0.72 |
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| 2008 |
Qi M, Aiken C. Nef enhances HIV-1 infectivity via association with the virus assembly complex. Virology. 373: 287-97. PMID 18191978 DOI: 10.1016/J.Virol.2007.12.001 |
0.709 |
|
| 2007 |
Schneidewind A, Brockman MA, Yang R, Adam RI, Li B, Le Gall S, Rinaldo CR, Craggs SL, Allgaier RL, Power KA, Kuntzen T, Tung CS, LaBute MX, Mueller SM, Harrer T, ... ... Aiken C, et al. Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication. Journal of Virology. 81: 12382-93. PMID 17804494 DOI: 10.1128/Jvi.01543-07 |
0.678 |
|
| 2007 |
Song C, Aiken C. Analysis of human cell heterokaryons demonstrates that target cell restriction of cyclosporine-resistant human immunodeficiency virus type 1 mutants is genetically dominant. Journal of Virology. 81: 11946-56. PMID 17715216 DOI: 10.1128/Jvi.00620-07 |
0.683 |
|
| 2007 |
Jiang J, Aiken C. Maturation-dependent human immunodeficiency virus type 1 particle fusion requires a carboxyl-terminal region of the gp41 cytoplasmic tail. Journal of Virology. 81: 9999-10008. PMID 17609279 DOI: 10.1128/Jvi.00592-07 |
0.704 |
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| 2007 |
Yang R, Aiken C. A mutation in alpha helix 3 of CA renders human immunodeficiency virus type 1 cyclosporin A resistant and dependent: rescue by a second-site substitution in a distal region of CA. Journal of Virology. 81: 3749-56. PMID 17267487 DOI: 10.1128/Jvi.02634-06 |
0.776 |
|
| 2007 |
Qi M, Aiken C. Selective restriction of Nef-defective human immunodeficiency virus type 1 by a proteasome-dependent mechanism. Journal of Virology. 81: 1534-6. PMID 17108041 DOI: 10.1128/Jvi.02099-06 |
0.728 |
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| 2007 |
Pion M, Arrighi JF, Jiang J, Lundquist CA, Hartley O, Aiken C, Piguet V. Analysis of HIV-1-X4 fusion with immature dendritic cells identifies a specific restriction that is independent of CXCR4 levels. The Journal of Investigative Dermatology. 127: 319-23. PMID 16917492 DOI: 10.1038/Sj.Jid.5700518 |
0.828 |
|
| 2006 |
Aiken C. Viral and cellular factors that regulate HIV-1 uncoating. Current Opinion in Hiv and Aids. 1: 194-9. PMID 19372808 DOI: 10.1097/01.Coh.0000221591.11294.C1 |
0.722 |
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| 2006 |
Zhou J, Chen CH, Aiken C. Human immunodeficiency virus type 1 resistance to the small molecule maturation inhibitor 3-O-(3',3'-dimethylsuccinyl)-betulinic acid is conferred by a variety of single amino acid substitutions at the CA-SP1 cleavage site in Gag. Journal of Virology. 80: 12095-101. PMID 17035324 DOI: 10.1128/Jvi.01626-06 |
0.716 |
|
| 2006 |
Shi J, Aiken C. Saturation of TRIM5 alpha-mediated restriction of HIV-1 infection depends on the stability of the incoming viral capsid. Virology. 350: 493-500. PMID 16624363 DOI: 10.1016/J.Virol.2006.03.013 |
0.68 |
|
| 2006 |
Dismuke DJ, Aiken C. Evidence for a functional link between uncoating of the human immunodeficiency virus type 1 core and nuclear import of the viral preintegration complex. Journal of Virology. 80: 3712-20. PMID 16571788 DOI: 10.1128/Jvi.80.8.3712-3720.2006 |
0.843 |
|
| 2006 |
Davis MR, Jiang J, Zhou J, Freed EO, Aiken C. A mutation in the human immunodeficiency virus type 1 Gag protein destabilizes the interaction of the envelope protein subunits gp120 and gp41. Journal of Virology. 80: 2405-17. PMID 16474147 DOI: 10.1128/Jvi.80.5.2405-2417.2006 |
0.737 |
|
| 2006 |
Jiang J, Aiken C. Maturation of the viral core enhances the fusion of HIV-1 particles with primary human T cells and monocyte-derived macrophages. Virology. 346: 460-8. PMID 16375941 DOI: 10.1016/J.Virol.2005.11.008 |
0.738 |
|
| 2005 |
Zhou J, Huang L, Hachey DL, Chen CH, Aiken C. Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles. The Journal of Biological Chemistry. 280: 42149-55. PMID 16251182 DOI: 10.1074/Jbc.M508951200 |
0.738 |
|
| 2005 |
VanCompernolle SE, Taylor RJ, Oswald-Richter K, Jiang J, Youree BE, Bowie JH, Tyler MJ, Conlon JM, Wade D, Aiken C, Dermody TS, KewalRamani VN, Rollins-Smith LA, Unutmaz D. Antimicrobial peptides from amphibian skin potently inhibit human immunodeficiency virus infection and transfer of virus from dendritic cells to T cells. Journal of Virology. 79: 11598-606. PMID 16140737 DOI: 10.1128/Jvi.79.18.11598-11606.2005 |
0.61 |
|
| 2005 |
Aiken C, Chen CH. Betulinic acid derivatives as HIV-1 antivirals. Trends in Molecular Medicine. 11: 31-6. PMID 15649820 DOI: 10.1016/J.Molmed.2004.11.001 |
0.617 |
|
| 2005 |
Forshey BM, Shi J, Aiken C. Structural requirements for recognition of the human immunodeficiency virus type 1 core during host restriction in owl monkey cells. Journal of Virology. 79: 869-75. PMID 15613315 DOI: 10.1128/Jvi.79.2.869-875.2005 |
0.847 |
|
| 2004 |
Zhou J, Chen CH, Aiken C. The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acid. Retrovirology. 1: 15. PMID 15225375 DOI: 10.1186/1742-4690-1-15 |
0.65 |
|
| 2004 |
Lundquist CA, Zhou J, Aiken C. Nef stimulates human immunodeficiency virus type 1 replication in primary T cells by enhancing virion-associated gp120 levels: coreceptor-dependent requirement for Nef in viral replication. Journal of Virology. 78: 6287-96. PMID 15163722 DOI: 10.1128/Jvi.78.12.6287-6296.2004 |
0.846 |
|
| 2004 |
Wyma DJ, Jiang J, Shi J, Zhou J, Lineberger JE, Miller MD, Aiken C. Coupling of human immunodeficiency virus type 1 fusion to virion maturation: a novel role of the gp41 cytoplasmic tail. Journal of Virology. 78: 3429-35. PMID 15016865 DOI: 10.1128/Jvi.78.7.3429-3435.2004 |
0.824 |
|
| 2004 |
Ganser-Pornillos BK, von Schwedler UK, Stray KM, Aiken C, Sundquist WI. Assembly properties of the human immunodeficiency virus type 1 CA protein. Journal of Virology. 78: 2545-52. PMID 14963157 DOI: 10.1128/Jvi.78.5.2545-2552.2004 |
0.503 |
|
| 2004 |
Huang L, Yuan X, Aiken C, Chen CH. Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action. Antimicrobial Agents and Chemotherapy. 48: 663-5. PMID 14742233 DOI: 10.1128/Aac.48.2.663-665.2004 |
0.719 |
|
| 2004 |
Zhou J, Yuan X, Dismuke D, Forshey BM, Lundquist C, Lee KH, Aiken C, Chen CH. Small-molecule inhibition of human immunodeficiency virus type 1 replication by specific targeting of the final step of virion maturation. Journal of Virology. 78: 922-9. PMID 14694123 DOI: 10.1128/Jvi.78.2.922-929.2004 |
0.819 |
|
| 2003 |
Tobiume M, Lineberger JE, Lundquist CA, Miller MD, Aiken C. Nef does not affect the efficiency of human immunodeficiency virus type 1 fusion with target cells. Journal of Virology. 77: 10645-50. PMID 12970449 DOI: 10.1128/Jvi.77.19.10645-10650.2003 |
0.865 |
|
| 2003 |
Forshey BM, Aiken C. Disassembly of human immunodeficiency virus type 1 cores in vitro reveals association of Nef with the subviral ribonucleoprotein complex. Journal of Virology. 77: 4409-14. PMID 12634398 DOI: 10.1128/Jvi.77.7.4409-4414.2003 |
0.861 |
|
| 2002 |
Forshey BM, von Schwedler U, Sundquist WI, Aiken C. Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replication. Journal of Virology. 76: 5667-77. PMID 11991995 DOI: 10.1128/Jvi.76.11.5667-5677.2002 |
0.852 |
|
| 2002 |
Lundquist CA, Tobiume M, Zhou J, Unutmaz D, Aiken C. Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. Journal of Virology. 76: 4625-33. PMID 11932428 DOI: 10.1128/Jvi.76.9.4625-4633.2002 |
0.828 |
|
| 2001 |
Zhou J, Aiken C. Nef enhances human immunodeficiency virus type 1 infectivity resulting from intervirion fusion: Evidence supporting a role for Nef at the virion envelope Journal of Virology. 75: 5851-5859. PMID 11390586 DOI: 10.1128/Jvi.75.13.5851-5859.2001 |
0.737 |
|
| 2001 |
Chazal N, Singer G, Aiken C, Hammarskjöld ML, Rekosh D. Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity Journal of Virology. 75: 4014-4018. PMID 11264394 DOI: 10.1128/Jvi.75.8.4014-4018.2001 |
0.674 |
|
| 2000 |
Wyma DJ, Kotov A, Aiken C. Evidence for a stable interaction of gp41 with Pr55(Gag) in immature human immunodeficiency virus type 1 particles. Journal of Virology. 74: 9381-7. PMID 11000206 DOI: 10.1128/Jvi.74.20.9381-9387.2000 |
0.815 |
|
| 1999 |
Kotov A, Zhou J, Flicker P, Aiken C. Association of Nef with the human immunodeficiency virus type 1 core. Journal of Virology. 73: 8824-30. PMID 10482638 DOI: 10.1128/Jvi.73.10.8824-8830.1999 |
0.75 |
|
| 1998 |
Aiken C. Mechanistic independence of Nef and cyclophilin A enhancement of human immunodeficiency virus type 1 infectivity Virology. 248: 139-147. PMID 9705263 DOI: 10.1006/Viro.1998.9254 |
0.737 |
|
| 1997 |
Aiken C. Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for nef and the sensitivity to Cyclosporin A Journal of Virology. 71: 5871-5877. PMID 9223476 DOI: 10.1128/Jvi.71.8.5871-5877.1997 |
0.756 |
|
| 1997 |
Mangasarian A, Foti M, Aiken C, Chin D, Carpentier JL, Trono D. The HIV-1 net protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane Immunity. 6: 67-77. PMID 9052838 DOI: 10.1016/S1074-7613(00)80243-5 |
0.429 |
|
| 1996 |
Aiken C, Krause L, Chen YL, Trono D. Mutational analysis of HIV-1 Nef: Identification of two mutants that are temperature-sensitive for CD4 downregulation Virology. 217: 293-300. PMID 8599214 DOI: 10.1006/Viro.1996.0116 |
0.553 |
|
| 1995 |
Gallay P, Swingler S, Aiken C, Trono D. HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator Cell. 80: 379-388. PMID 7859280 DOI: 10.1016/0092-8674(95)90488-3 |
0.624 |
|
| 1995 |
Koval V, Jault FM, Pal PG, Moreno TN, Aiken C, Trono D, Spector SA, Spector DH. Differential effects of human cytomegalovirus on integrated and unintegrated human immunodeficiency virus sequences Journal of Virology. 69: 1645-1651. PMID 7853500 DOI: 10.1128/Jvi.69.3.1645-1651.1995 |
0.706 |
|
| 1995 |
Aiken C, Trono D. Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis Journal of Virology. 69: 5048-5056. PMID 7541845 DOI: 10.1128/Jvi.69.8.5048-5056.1995 |
0.749 |
|
| 1994 |
Aiken C, Konner J, Landau NR, Lenburg ME, Trono D. Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell. 76: 853-64. PMID 8124721 DOI: 10.1016/0092-8674(94)90360-3 |
0.405 |
|
| 1993 |
Von Schwedler U, Song J, Aiken C, Trono D. vif Is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells Journal of Virology. 67: 4945-4955. PMID 8331734 DOI: 10.1128/Jvi.67.8.4945-4955.1993 |
0.713 |
|
| 1992 |
Aiken CGA. HIV-1 infection and perinatal mortality in Zimbabwe Archives of Disease in Childhood. 67: 595-599. PMID 1599295 |
0.378 |
|
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