Jan M. van Deursen - Publications

Affiliations: 
Biochemistry and Molecular Biology College of Medicine - Mayo Clinic 
Area:
Molecular Biology, Biochemistry, Cell Biology

71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Limzerwala JF, van Deursen JM. Crystallizing BubR1's kinase activity. Cell Research. PMID 31253942 DOI: 10.1038/s41422-019-0199-7  0.32
2016 Kanakkanthara A, Jeganathan KB, Limzerwala JF, Baker DJ, Hamada M, Nam HJ, van Deursen WH, Hamada N, Naylor RM, Becker NA, Davies BA, van Ree JH, Mer G, Shapiro VS, Maher LJ, ... ... van Deursen JM, et al. Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation. Science (New York, N.Y.). 353: 1549-1552. PMID 27708105 DOI: 10.1126/science.aaf7463  0.52
2016 van Ree JH, Nam HJ, Jeganathan KB, Kanakkanthara A, van Deursen JM. Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes. Nature Cell Biology. PMID 27240320 DOI: 10.1038/ncb3369  0.52
2016 Kakkar V, Månsson C, de Mattos EP, Bergink S, van der Zwaag M, van Waarde MA, Kloosterhuis NJ, Melki R, van Cruchten RT, Al-Karadaghi S, Arosio P, Dobson CM, Knowles TP, Bates GP, van Deursen JM, et al. The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model. Molecular Cell. PMID 27151442 DOI: 10.1016/j.molcel.2016.03.017  0.52
2016 Yamazaki Y, Baker DJ, Tachibana M, Liu CC, van Deursen JM, Brott TG, Bu G, Kanekiyo T. Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown. Stroke; a Journal of Cerebral Circulation. PMID 26883501 DOI: 10.1161/STROKEAHA.115.010835  0.52
2016 Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, A Saltness R, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM. Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature. PMID 26840489 DOI: 10.1038/nature16932  0.52
2016 Naylor RM, Jeganathan KB, Cao X, van Deursen JM. Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy. The Journal of Clinical Investigation. PMID 26731471 DOI: 10.1172/JCI82277  0.52
2015 Lee SB, Kim JJ, Nam HJ, Gao B, Yin P, Qin B, Yi SY, Ham H, Evans D, Kim SH, Zhang J, Deng M, Liu T, Zhang H, Billadeau DD, ... ... van Deursen JM, et al. Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1. Molecular Cell. PMID 26387737 DOI: 10.1016/j.molcel.2015.08.011  0.52
2015 Touati SA, Buffin E, Cladière D, Hached K, Rachez C, van Deursen JM, Wassmann K. Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest. Nature Communications. 6: 6946. PMID 25897860 DOI: 10.1038/ncomms7946  0.52
2015 Giotopoulos G, Chan WI, Horton SJ, Ruau D, Gallipoli P, Fowler A, Crawley C, Papaemmanuil E, Campbell PJ, Göttgens B, Van Deursen JM, Cole PA, Huntly BJ. The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia. Oncogene. PMID 25893291 DOI: 10.1038/onc.2015.92  0.52
2015 Dhanasekaran R, Nakamura I, Hu C, Chen G, Oseini AM, Seven ES, Miamen AG, Moser CD, Zhou W, van Kuppevelt TH, van Deursen JM, Mounajjed T, Fernandez-Zapico ME, Roberts LR. Activation of the transforming growth factor-β/SMAD transcriptional pathway underlies a novel tumor-promoting role of sulfatase 1 in hepatocellular carcinoma. Hepatology (Baltimore, Md.). 61: 1269-83. PMID 25503294 DOI: 10.1002/hep.27658  0.52
2015 Nam HJ, Naylor RM, van Deursen JM. Centrosome dynamics as a source of chromosomal instability. Trends in Cell Biology. 25: 65-73. PMID 25455111 DOI: 10.1016/j.tcb.2014.10.002  0.52
2014 Maskey RS, Kim MS, Baker DJ, Childs B, Malureanu LA, Jeganathan KB, Machida Y, van Deursen JM, Machida YJ. Spartan deficiency causes genomic instability and progeroid phenotypes. Nature Communications. 5: 5744. PMID 25501849 DOI: 10.1038/ncomms6744  0.52
2014 Childs BG, Baker DJ, Kirkland JL, Campisi J, van Deursen JM. Senescence and apoptosis: dueling or complementary cell fates? Embo Reports. 15: 1139-53. PMID 25312810 DOI: 10.15252/embr.201439245  0.52
2014 van Deursen JM. The role of senescent cells in ageing. Nature. 509: 439-46. PMID 24848057 DOI: 10.1038/nature13193  0.52
2014 North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The Embo Journal. 33: 1438-53. PMID 24825348 DOI: 10.15252/embj.201386907  0.52
2014 Nam HJ, van Deursen JM. Cyclin B2 and p53 control proper timing of centrosome separation. Nature Cell Biology. 16: 538-49. PMID 24776885 DOI: 10.1038/ncb2952  0.52
2014 Behrens A, van Deursen JM, Rudolph KL, Schumacher B. Impact of genomic damage and ageing on stem cell function. Nature Cell Biology. 16: 201-7. PMID 24576896 DOI: 10.1038/ncb2928  0.52
2013 Ricke RM, van Deursen JM. Aneuploidy in health, disease, and aging. The Journal of Cell Biology. 201: 11-21. PMID 23547028 DOI: 10.1083/jcb.201301061  0.52
2013 Zanivan S, Meves A, Behrendt K, Schoof EM, Neilson LJ, Cox J, Tang HR, Kalna G, van Ree JH, van Deursen JM, Trempus CS, Machesky LM, Linding R, Wickström SA, Fässler R, et al. In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis. Cell Reports. 3: 552-66. PMID 23375375 DOI: 10.1016/j.celrep.2013.01.003  0.52
2013 Baker DJ, Dawlaty MM, Wijshake T, Jeganathan KB, Malureanu L, van Ree JH, Crespo-Diaz R, Reyes S, Seaburg L, Shapiro V, Behfar A, Terzic A, van de Sluis B, van Deursen JM. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nature Cell Biology. 15: 96-102. PMID 23242215 DOI: 10.1038/ncb2643  0.52
2013 Naylor RM, Baker DJ, van Deursen JM. Senescent cells: a novel therapeutic target for aging and age-related diseases. Clinical Pharmacology and Therapeutics. 93: 105-16. PMID 23212104 DOI: 10.1038/clpt.2012.193  0.52
2012 Wijshake T, Malureanu LA, Baker DJ, Jeganathan KB, van de Sluis B, van Deursen JM. Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation. Plos Genetics. 8: e1003138. PMID 23300461 DOI: 10.1371/journal.pgen.1003138  0.52
2012 Ricke RM, Jeganathan KB, Malureanu L, Harrison AM, van Deursen JM. Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression. The Journal of Cell Biology. 199: 931-49. PMID 23209306 DOI: 10.1083/jcb.201205115  0.52
2012 Hamada M, Malureanu LA, Wijshake T, Zhou W, van Deursen JM, Sullivan BA. Reprogramming to Pluripotency Can Conceal Somatic Cell Chromosomal Instability Plos Genetics. 8. PMID 22952451 DOI: 10.1371/journal.pgen.1002913  0.52
2012 Ricke RM, van Deursen JM. Sgo1 as a "guardian spirit" for preventing colon tumorigenesis. Cell Cycle (Georgetown, Tex.). 11: 649. PMID 22374668 DOI: 10.4161/cc.11.4.19360  0.52
2011 Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. 479: 232-6. PMID 22048312 DOI: 10.1038/nature10600  0.52
2011 Ricke RM, van Deursen JM. Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregation. Cell Cycle (Georgetown, Tex.). 10: 3645-51. PMID 22033440 DOI: 10.4161/cc.10.21.18156  0.52
2011 Bakeberg JL, Tammachote R, Woollard JR, Hogan MC, Tuan HF, Li M, van Deursen JM, Wu Y, Huang BQ, Torres VE, Harris PC, Ward CJ. Epitope-tagged Pkhd1 tracks the processing, secretion, and localization of fibrocystin. Journal of the American Society of Nephrology : Jasn. 22: 2266-77. PMID 22021705 DOI: 10.1681/ASN.2010111173  0.52
2011 Chan WI, Hannah RL, Dawson MA, Pridans C, Foster D, Joshi A, Göttgens B, Van Deursen JM, Huntly BJ. The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells. Molecular and Cellular Biology. 31: 5046-60. PMID 22006020 DOI: 10.1128/MCB.05830-11  0.52
2011 Hamada M, Haeger A, Jeganathan KB, van Ree JH, Malureanu L, Wälde S, Joseph J, Kehlenbach RH, van Deursen JM. Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability. The Journal of Cell Biology. 194: 597-612. PMID 21859863 DOI: 10.1083/jcb.201102018  0.52
2011 Ricke RM, Jeganathan KB, van Deursen JM. Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation. The Journal of Cell Biology. 193: 1049-64. PMID 21646403 DOI: 10.1083/jcb.201012035  0.52
2011 Ricke RM, van Deursen JM. Correction of microtubule-kinetochore attachment errors: mechanisms and role in tumor suppression. Seminars in Cell & Developmental Biology. 22: 559-65. PMID 21439393 DOI: 10.1016/j.semcdb.2011.03.007  0.52
2011 van Ree J, Zhou W, Li M, van Deursen JM. Transgenesis in mouse embryonic stem cells. Methods in Molecular Biology (Clifton, N.J.). 693: 143-62. PMID 21080279 DOI: 10.1007/978-1-60761-974-1_9  0.52
2010 Malureanu L, Jeganathan KB, Jin F, Baker DJ, van Ree JH, Gullon O, Chen Z, Henley JR, van Deursen JM. Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis. The Journal of Cell Biology. 191: 313-29. PMID 20956380 DOI: 10.1083/jcb.201003090  0.52
2010 Jin F, Hamada M, Malureanu L, Jeganathan KB, Zhou W, Morbeck DE, van Deursen JM. Cdc20 is critical for meiosis I and fertility of female mice. Plos Genetics. 6: e1001147. PMID 20941357 DOI: 10.1371/journal.pgen.1001147  0.52
2010 Chen G, Zou X, Watanabe H, van Deursen JM, Shen J. CREB binding protein is required for both short-term and long-term memory formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13066-77. PMID 20881124 DOI: 10.1523/JNEUROSCI.2378-10.2010  0.52
2010 Li M, Fang X, Baker DJ, Guo L, Gao X, Wei Z, Han S, van Deursen JM, Zhang P. The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 14188-93. PMID 20663956 DOI: 10.1073/pnas.1005960107  0.52
2010 Baker DJ, van Deursen JM. Chromosome missegregation causes colon cancer by APC loss of heterozygosity. Cell Cycle (Georgetown, Tex.). 9: 1711-6. PMID 20404532 DOI: 10.4161/cc.9.9.11314  0.52
2010 van Ree JH, Jeganathan KB, Malureanu L, van Deursen JM. Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation. The Journal of Cell Biology. 188: 83-100. PMID 20065091 DOI: 10.1083/jcb.200906147  0.52
2009 Baker DJ, Jin F, Jeganathan KB, van Deursen JM. Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell. 16: 475-86. PMID 19962666 DOI: 10.1016/j.ccr.2009.10.023  0.52
2009 Shin S, Kim TD, Jin F, van Deursen JM, Dehm SM, Tindall DJ, Grande JP, Munz JM, Vasmatzis G, Janknecht R. Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81. Cancer Research. 69: 8102-10. PMID 19789348 DOI: 10.1158/0008-5472.CAN-09-0941  0.52
2009 Liu Y, Malureanu L, Jeganathan KB, Tran DD, Lindquist LD, van Deursen JM, Bram RJ. CAML loss causes anaphase failure and chromosome missegregation. Cell Cycle (Georgetown, Tex.). 8: 940-9. PMID 19229138  0.52
2009 Malureanu LA, Jeganathan KB, Hamada M, Wasilewski L, Davenport J, van Deursen JM. BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase. Developmental Cell. 16: 118-31. PMID 19154723 DOI: 10.1016/j.devcel.2008.11.004  0.52
2008 Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen JM, Tindall DJ, Chen J. Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nature Cell Biology. 10: 1076-82. PMID 19160488 DOI: 10.1038/ncb1767  0.52
2008 Baker DJ, Jin F, van Deursen JM. The yin and yang of the Cdkn2a locus in senescence and aging. Cell Cycle (Georgetown, Tex.). 7: 2795-802. PMID 18769141  0.52
2008 Rensen SS, Niessen PM, van Deursen JM, Janssen BJ, Heijman E, Hermeling E, Meens M, Lie N, Gijbels MJ, Strijkers GJ, Doevendans PA, Hofker MH, De Mey JG, van Eys GJ. Smoothelin-B deficiency results in reduced arterial contractility, hypertension, and cardiac hypertrophy in mice. Circulation. 118: 828-36. PMID 18678771 DOI: 10.1161/CIRCULATIONAHA.107.743690  0.52
2008 Ricke RM, van Ree JH, van Deursen JM. Whole chromosome instability and cancer: a complex relationship. Trends in Genetics : Tig. 24: 457-66. PMID 18675487 DOI: 10.1016/j.tig.2008.07.002  0.52
2008 Baker DJ, Perez-Terzic C, Jin F, Pitel KS, Pitel K, Niederländer NJ, Jeganathan K, Yamada S, Reyes S, Rowe L, Hiddinga HJ, Eberhardt NL, Terzic A, van Deursen JM. Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nature Cell Biology. 10: 825-36. PMID 18516091 DOI: 10.1038/ncb1744  0.52
2008 Dawlaty MM, Malureanu L, Jeganathan KB, Kao E, Sustmann C, Tahk S, Shuai K, Grosschedl R, van Deursen JM. Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell. 133: 103-15. PMID 18394993 DOI: 10.1016/j.cell.2008.01.045  0.52
2008 Huen MS, Sy SM, van Deursen JM, Chen J. Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. The Journal of Biological Chemistry. 283: 11073-7. PMID 18319261 DOI: 10.1074/jbc.C700242200  0.52
2007 Jeganathan K, Malureanu L, Baker DJ, Abraham SC, van Deursen JM. Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. The Journal of Cell Biology. 179: 255-67. PMID 17938250 DOI: 10.1083/jcb.200706015  0.52
2007 Baker DJ, Dawlaty MM, Galardy P, van Deursen JM. Mitotic regulation of the anaphase-promoting complex. Cellular and Molecular Life Sciences : Cmls. 64: 589-600. PMID 17334950 DOI: 10.1007/s00018-007-6443-1  0.52
2007 Matsumoto T, Baker DJ, d'Uscio LV, Mozammel G, Katusic ZS, van Deursen JM. Aging-associated vascular phenotype in mutant mice with low levels of BubR1. Stroke; a Journal of Cerebral Circulation. 38: 1050-6. PMID 17272762 DOI: 10.1161/01.STR.0000257967.86132.01  0.52
2007 van Deursen JM. Rb loss causes cancer by driving mitosis mad. Cancer Cell. 11: 1-3. PMID 17222786 DOI: 10.1016/j.ccr.2006.12.006  0.52
2007 Hartman TK, Wengenack TM, Poduslo JF, van Deursen JM. Mutant mice with small amounts of BubR1 display accelerated age-related gliosis. Neurobiology of Aging. 28: 921-7. PMID 16781018 DOI: 10.1016/j.neurobiolaging.2006.05.012  0.52
2006 Dawlaty MM, van Deursen JM. Gene targeting methods for studying nuclear transport factors in mice. Methods (San Diego, Calif.). 39: 370-8. PMID 16887365 DOI: 10.1016/j.ymeth.2006.06.009  0.52
2006 Jeganathan KB, Van Deursen JM. Differential mitotic checkpoint protein requirements in somatic and germ cells Biochemical Society Transactions. 34: 583-586. PMID 16856867 DOI: 10.1042/BST0340583  0.52
2006 Jeganathan KB, Baker DJ, van Deursen JM. Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition. Cell Cycle (Georgetown, Tex.). 5: 366-70. PMID 16479161  0.52
2005 Jeganathan KB, Malureanu L, van Deursen JM. The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation. Nature. 438: 1036-9. PMID 16355229 DOI: 10.1038/nature04221  0.52
2005 Juneja SC, van Deursen JM. A mouse model of familial oligoasthenoteratozoospermia. Human Reproduction (Oxford, England). 20: 881-93. PMID 15705627 DOI: 10.1093/humrep/deh719  0.52
2005 Subramaniam M, Gorny G, Johnsen SA, Monroe DG, Evans GL, Fraser DG, Rickard DJ, Rasmussen K, van Deursen JM, Turner RT, Oursler MJ, Spelsberg TC. TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro. Molecular and Cellular Biology. 25: 1191-9. PMID 15657444 DOI: 10.1128/MCB.25.3.1191-1199.2005  0.52
2004 Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A, Kumar R, Jenkins RB, de Groen PC, Roche P, van Deursen JM. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nature Genetics. 36: 744-9. PMID 15208629 DOI: 10.1038/ng1382  0.52
2003 Liu ST, van Deursen JM, Yen TJ. The role of mitotic checkpoint in maintaining genomic stability. Current Topics in Developmental Biology. 58: 27-51. PMID 14711012 DOI: 10.1016/S0070-2153(03)58002-4  0.52
2003 Babu JR, Jeganathan KB, Baker DJ, Wu X, Kang-Decker N, van Deursen JM. Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. The Journal of Cell Biology. 160: 341-53. PMID 12551952 DOI: 10.1083/jcb.200211048  0.52
2002 Kasper LH, Boussouar F, Ney PA, Jackson CW, Rehg J, van Deursen JM, Brindle PK. A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature. 419: 738-43. PMID 12384703 DOI: 10.1038/nature01062  0.52
2001 Von Bülow GU, Van Deursen JM, Bram RJ. Regulation of the T-independent humoral response by TACI Immunity. 14: 573-582. PMID 11371359 DOI: 10.1016/S1074-7613(01)00130-3  0.52
1998 Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, Wang D, Brown M, Bodner S, Grosveld G, Ihle JN. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell. 93: 841-50. PMID 9630227 DOI: 10.1016/S0092-8674(00)81444-0  0.52
1998 Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, Vanin EF, Bodner S, Colamonici OR, van Deursen JM, Grosveld G, Ihle JN. Jak2 is essential for signaling through a variety of cytokine receptors. Cell. 93: 385-95. PMID 9590173 DOI: 10.1016/S0092-8674(00)81167-8  0.52
1998 Martin F, Van Deursen JM, Shivdasani RA, Jackson CW, Troutman AG, Ney PA. Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and Nrf-2 Blood. 91: 3459-3466. PMID 9558405  0.52
1996 Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Vignali DA, Doherty PC, Grosveld GC, Ihle JN. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature. 382: 171-4. PMID 8700208 DOI: 10.1038/382171a0  0.52
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