| Year |
Citation |
Score |
| 2024 |
Carlson RJ, Patten JJ, Stefanakis G, Soong BY, Radhakrishnan A, Singh A, Thakur N, Amarasinghe GK, Hacohen N, Basler CF, Leung D, Uhler C, Davey RA, Blainey PC. Single-cell image-based genetic screens systematically identify regulators of Ebola virus subcellular infection dynamics. Biorxiv : the Preprint Server For Biology. PMID 38617272 DOI: 10.1101/2024.04.06.588168 |
0.695 |
|
| 2023 |
Vogel OA, Forwood JK, Leung DW, Amarasinghe GK, Basler CF. Viral Targeting of Importin Alpha-Mediated Nuclear Import to Block Innate Immunity. Cells. 13. PMID 38201275 DOI: 10.3390/cells13010071 |
0.657 |
|
| 2023 |
Qavi AJ, Jiang Q, Aman MJ, Vu H, Zetlin L, Dye JM, Froude JW, Leung DW, Holtsberg F, Crick SL, Amarasinghe GK. A Flexible, Quantitative Plasmonic-Fluor Lateral Flow Assay for the Rapid Detection of and . Acs Infectious Diseases. PMID 38048277 DOI: 10.1021/acsinfecdis.3c00423 |
0.606 |
|
| 2023 |
Ganaie SS, Leung DW, Hartman AL, Amarasinghe GK. Host entry factors of Rift Valley Fever Virus infection. Advances in Virus Research. 117: 121-136. PMID 37832991 DOI: 10.1016/bs.aivir.2023.09.001 |
0.69 |
|
| 2023 |
Wu C, Wagner N, Moyle AB, Feng A, Sharma N, Stubbs SH, Donahue C, Davey R, Gross ML, Leung DW, Amarasinghe GK. The Ebola NP0VP35 Complex Phase Separates into Inclusion Body-Like Structures. Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 29: 941. PMID 37613387 DOI: 10.1093/micmic/ozad067.468 |
0.539 |
|
| 2023 |
Wu C, Wagner N, Moyle AB, Feng A, Sharma N, Stubbs SH, Donahue C, Davey RA, Gross ML, Leung DW, Amarasinghe GK. The intricacies of Ebola NPVP35 formation of inclusion body-like structures and their disruption reducing viral infection. Journal of Molecular Biology. 168241. PMID 37598728 DOI: 10.1016/j.jmb.2023.168241 |
0.656 |
|
| 2023 |
Schwarz MM, Ganaie SS, Feng A, Brown G, Yangdon T, White JM, Hoehl RM, McMillen CM, Rush RE, Connors KA, Cui X, Leung DW, Egawa T, Amarasinghe GK, Hartman AL. Lrp1 is essential for lethal Rift Valley fever hepatic disease in mice. Science Advances. 9: eadh2264. PMID 37450601 DOI: 10.1126/sciadv.adh2264 |
0.597 |
|
| 2023 |
Ramanathan P, Tigabu B, Santos RI, Ilinykh PA, Kuzmina N, Vogel OA, Thakur N, Ahmed H, Wu C, Amarasinghe GK, Basler CF, Bukreyev A. Ebolavirus Species-Specific Interferon Antagonism Mediated by VP24. Viruses. 15. PMID 37243162 DOI: 10.3390/v15051075 |
0.307 |
|
| 2023 |
Mishra N, Kant R, Leung DW, Gross ML, Amarasinghe GK. Biochemical and HDX Mass Spectral Characterization of the SARS-CoV-2 Nsp1 Protein. Biochemistry. PMID 37205707 DOI: 10.1021/acs.biochem.3c00035 |
0.677 |
|
| 2022 |
van Vliet VJE, Huynh N, Palà J, Patel A, Singer A, Slater C, Chung J, van Huizen M, Teyra J, Miersch S, Luu GK, Ye W, Sharma N, Ganaie SS, Russell R, ... ... Amarasinghe GK, et al. Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site. Plos Pathogens. 18: e1011065. PMID 36548304 DOI: 10.1371/journal.ppat.1011065 |
0.362 |
|
| 2022 |
Schwarz MM, Connors KA, Davoli KA, McMillen CM, Albe JR, Hoehl RM, Demers MJ, Ganaie SS, Price DA, Leung DW, Amarasinghe GK, McElroy AK, Reed DS, Hartman AL. Rift Valley Fever Virus Infects the Posterior Segment of the Eye and Induces Inflammation in a Rat Model of Ocular Disease. Journal of Virology. e0111222. PMID 36194021 DOI: 10.1128/jvi.01112-22 |
0.575 |
|
| 2022 |
Meserve K, Qavi AJ, Aman MJ, Vu H, Zeitlin L, Dye JM, Froude JW, Leung DW, Yang L, Holtsberg FW, Amarasinghe GK, Bailey RC. Detection of biomarkers for filoviral infection with a silicon photonic resonator platform. Star Protocols. 3: 101719. PMID 36153732 DOI: 10.1016/j.xpro.2022.101719 |
0.595 |
|
| 2022 |
Schwarz MM, Price DA, Ganaie SS, Feng A, Mishra N, Hoehl RM, Fatma F, Stubbs SH, Whelan SPJ, Cui X, Egawa T, Leung DW, Amarasinghe GK, Hartman AL. Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1. Proceedings of the National Academy of Sciences of the United States of America. 119: e2204706119. PMID 35939689 DOI: 10.1073/pnas.2204706119 |
0.661 |
|
| 2022 |
Qavi AJ, Wu C, Lloyd M, Zaman MM, Luan J, Ballman C, Leung DW, Crick SL, Farnsworth CW, Amarasinghe GK. Plasmonic Fluor-Enhanced Antigen Arrays for High-Throughput, Serological Studies of SARS-CoV-2. Acs Infectious Diseases. PMID 35867632 DOI: 10.1021/acsinfecdis.2c00086 |
0.563 |
|
| 2022 |
Mishra N, Teyra J, Boytz R, Miersch S, Merritt TN, Cardarelli L, Gorelik M, Mihalic F, Jemth P, Davey RA, Sidhu SS, Leung DW, Amarasinghe GK. Monoclonal antibodies binding data for SARS-CoV-2 proteins. Data in Brief. 43: 108415. PMID 35789908 DOI: 10.1016/j.dib.2022.108415 |
0.591 |
|
| 2022 |
Qavi AJ, Meserve K, Aman MJ, Vu H, Zeitlin L, Dye JM, Froude JW, Leung DW, Yang L, Holtsberg FW, Bailey RC, Amarasinghe GK. Rapid detection of an Ebola biomarker with optical microring resonators. Cell Reports Methods. 2: 100234. PMID 35784644 DOI: 10.1016/j.crmeth.2022.100234 |
0.571 |
|
| 2022 |
Labriola JM, Miersch S, Chen G, Chen C, Pavlenco A, Saberianfar R, Caccuri F, Zani A, Sharma N, Feng A, Leung DW, Caruso A, Novelli G, Amarasinghe GK, Sidhu SS. Peptide-Antibody Fusions Engineered by Phage Display Exhibit an Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants. Acs Chemical Biology. PMID 35731947 DOI: 10.1021/acschembio.2c00411 |
0.589 |
|
| 2022 |
Kailasan S, Kant R, Noonan-Shueh M, Kanipakala T, Liao G, Shulenin S, Leung DW, Alm RA, Adhikari RP, Amarasinghe GK, Gross ML, Aman MJ. Antigenic landscapes on pore-forming toxins reveal insights into specificity and cross-neutralization. Mabs. 14: 2083467. PMID 35730685 DOI: 10.1080/19420862.2022.2083467 |
0.585 |
|
| 2022 |
Wu C, Holehouse AS, Leung DW, Amarasinghe GK, Dutch RE. Liquid Phase Partitioning in Virus Replication: Observations and Opportunities. Annual Review of Virology. PMID 35709511 DOI: 10.1146/annurev-virology-093020-013659 |
0.659 |
|
| 2022 |
Boggs KB, Edmonds K, Cifuentes-Munoz N, El Najjar F, Ossandón C, Roe M, Wu C, Moncman CL, Creamer TP, Amarasinghe GK, Leung DW, Dutch RE. Human Metapneumovirus Phosphoprotein Independently Drives Phase Separation and Recruits Nucleoprotein to Liquid-Like Bodies. Mbio. e0109922. PMID 35536005 DOI: 10.1128/mbio.01099-22 |
0.625 |
|
| 2022 |
Cruz MA, Frederick TE, Mallimadugula UL, Singh S, Vithani N, Zimmerman MI, Porter JR, Moeder KE, Amarasinghe GK, Bowman GR. A cryptic pocket in Ebola VP35 allosterically controls RNA binding. Nature Communications. 13: 2269. PMID 35477718 DOI: 10.1038/s41467-022-29927-9 |
0.347 |
|
| 2022 |
Mishra N, Teyra J, Boytz R, Miersch S, Merritt TN, Cardarelli L, Gorelik M, Mihalic F, Jemth P, Davey R, Sidhu SS, Leung DW, Amarasinghe GK. Development of monoclonal antibodies to detect for SARS-CoV-2 proteins. Journal of Molecular Biology. 167583. PMID 35405107 DOI: 10.1016/j.jmb.2022.167583 |
0.632 |
|
| 2022 |
Wang L, Asare E, Shetty AC, Sanchez-Tumbaco F, Edwards MR, Saranathan R, Weinrick B, Xu J, Chen B, Bénard A, Dougan G, Leung DW, Amarasinghe GK, Chan J, Basler CF, et al. Multiple genetic paths including massive gene amplification allow to overcome loss of ESX-3 secretion system substrates. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35193958 DOI: 10.1073/pnas.2112608119 |
0.568 |
|
| 2022 |
Wagner ND, Liu H, Rohrs HW, Amarasinghe GK, Gross ML, Leung DW. Nipah Virus V Protein Binding Alters MDA5 Helicase Folding Dynamics. Acs Infectious Diseases. 8: 118-128. PMID 35026950 DOI: 10.1021/acsinfecdis.1c00403 |
0.634 |
|
| 2022 |
Wang Y, Binning JM, Pintilie GD, Chiu W, Amarasinghe GK, Leung DW, Su Z. Cryo-EM analysis of Ebola virus nucleocapsid-like assembly. Star Protocols. 3: 101030. PMID 34977676 DOI: 10.1016/j.xpro.2021.101030 |
0.786 |
|
| 2021 |
Pei J, Beri NR, Zou AJ, Hubel P, Dorando HK, Bergant V, Andrews RD, Pan J, Andrews JM, Sheehan KCF, Pichlmair A, Amarasinghe GK, Brody SL, Payton JE, Leung DW. Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription. Cell Reports. 37: 109803. PMID 34644581 DOI: 10.1016/j.celrep.2021.109803 |
0.664 |
|
| 2021 |
Wu C, Qavi AJ, Moyle AB, Wagner ND, Hachim A, Kavian N, Cole AR, Sweeney-Gibbons J, Rohrs HW, Peiris JSM, Basler CF, Gross ML, Valkenburg SA, Farnsworth CW, Amarasinghe GK, et al. Domain-specific biochemical and serological characterization of SARS-CoV-2 nucleocapsid protein. Star Protocols. 100906. PMID 34642671 DOI: 10.1016/j.xpro.2021.100906 |
0.645 |
|
| 2021 |
Ganaie SS, Schwarz MM, McMillen CM, Price DA, Feng AX, Albe JR, Wang W, Miersch S, Orvedahl A, Cole AR, Sentmanat MF, Mishra N, Boyles DA, Koenig ZT, Kujawa MR, ... ... Amarasinghe GK, et al. Lrp1 is a host entry factor for Rift Valley fever virus. Cell. PMID 34559985 DOI: 10.1016/j.cell.2021.09.001 |
0.667 |
|
| 2021 |
Miersch S, Li Z, Saberianfar R, Ustav M, Brett Case J, Blazer L, Chen C, Ye W, Pavlenco A, Gorelik M, Garcia Perez J, Subramania S, Singh S, Ploder L, Ganaie S, ... ... Amarasinghe GK, et al. Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations. Journal of Molecular Biology. 167177. PMID 34329642 DOI: 10.1016/j.jmb.2021.167177 |
0.649 |
|
| 2021 |
Batra J, Mori H, Small GI, Anantpadma M, Shtanko O, Mishra N, Zhang M, Liu D, Williams CG, Biedenkopf N, Becker S, Gross ML, Leung DW, Davey RA, Amarasinghe GK, et al. Non-canonical proline-tyrosine interactions with multiple host proteins regulate Ebola virus infection. The Embo Journal. e105658. PMID 34260076 DOI: 10.15252/embj.2020105658 |
0.801 |
|
| 2021 |
Wu C, Qavi AJ, Hachim A, Kavian N, Cole AR, Moyle AB, Wagner ND, Sweeney-Gibbons J, Rohrs HW, Gross ML, Peiris JSM, Basler CF, Farnsworth CW, Valkenburg SA, Amarasinghe GK, et al. . Iscience. 102681. PMID 34095780 DOI: 10.1016/j.isci.2021.102681 |
0.621 |
|
| 2021 |
Pei J, Wagner ND, Zou AJ, Chatterjee S, Borek D, Cole AR, Kim PJ, Basler CF, Otwinowski Z, Gross ML, Amarasinghe GK, Leung DW. Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33649232 DOI: 10.1073/pnas.2020587118 |
0.706 |
|
| 2020 |
Miersch S, Li Z, Saberianfar R, Ustav M, Case JB, Blazer L, Chen C, Ye W, Pavlenco A, Gorelik M, Perez JG, Subramania S, Singh S, Ploder L, Ganaie S, ... ... Amarasinghe GK, et al. Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations. Biorxiv : the Preprint Server For Biology. PMID 33398270 DOI: 10.1101/2020.10.31.362848 |
0.648 |
|
| 2020 |
Wu C, Qavi AJ, Hachim A, Kavian N, Cole AR, Moyle AB, Wagner ND, Sweeney-Gibbons J, Rohrs HW, Gross ML, Peiris JSM, Basler CF, Farnsworth CW, Valkenburg SA, Amarasinghe GK, et al. Characterization of SARS-CoV-2 N protein reveals multiple functional consequences of the C-terminal domain. Biorxiv : the Preprint Server For Biology. PMID 33269347 DOI: 10.1101/2020.11.30.404905 |
0.637 |
|
| 2020 |
Case JB, Rothlauf PW, Chen RE, Liu Z, Zhao H, Kim AS, Bloyet LM, Zeng Q, Tahan S, Droit L, Ilagan MXG, Tartell MA, Amarasinghe G, Henderson JP, Miersch S, et al. Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2. Cell Host & Microbe. PMID 32735849 DOI: 10.1016/J.Chom.2020.06.021 |
0.387 |
|
| 2020 |
Aceti DJ, Ahmed H, Westler WM, Wu C, Dashti H, Tonelli M, Eghbalnia H, Amarasinghe GK, Markley JL. Fragment screening targeting Ebola virus nucleoprotein C-terminal domain identifies lead candidates. Antiviral Research. 104822. PMID 32446802 DOI: 10.1016/J.Antiviral.2020.104822 |
0.499 |
|
| 2020 |
Wang W, Shin WJ, Zhang B, Choi Y, Yoo JS, Zimmerman MI, Frederick TE, Bowman GR, Gross ML, Leung DW, Jung JU, Amarasinghe GK. The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target. Cell Reports. 30: 153-163.e5. PMID 31914382 DOI: 10.1016/J.Celrep.2019.12.020 |
0.7 |
|
| 2020 |
Edwards MR, Liu G, De S, Sourimant J, Pietzsch C, Johnson B, Amarasinghe GK, Leung DW, Bukreyev A, Plemper RK, Aron Z, Bowlin TL, Moir DT, Basler CF. Small molecule compounds that inhibit antioxidant response gene expression in an inducer-dependent manner. Acs Infectious Diseases. PMID 31899866 DOI: 10.1021/Acsinfecdis.9B00416 |
0.618 |
|
| 2019 |
Ivanov A, Ramanathan P, Parry C, Ilinykh PA, Lin X, Petukhov M, Obukhov Y, Ammosova T, Amarasinghe GK, Bukreyev A, Nekhai S. Global phosphoproteomic analysis of Ebola virions reveals a novel role for VP35 phosphorylation-dependent regulation of genome transcription. Cellular and Molecular Life Sciences : Cmls. PMID 31562565 DOI: 10.1007/S00018-019-03303-1 |
0.453 |
|
| 2019 |
Wang W, Wu C, Amarasinghe GK, Leung DW. Ebola Virus Replication Stands Out. Trends in Microbiology. PMID 31155428 DOI: 10.1016/J.Tim.2019.05.004 |
0.69 |
|
| 2019 |
Lee S, Liu H, Wilen CB, Sychev ZE, Desai C, Hykes BL, Orchard RC, McCune BT, Kim KW, Nice TJ, Handley SA, Baldridge MT, Amarasinghe GK, Virgin HW. A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis. Cell Host & Microbe. PMID 31130511 DOI: 10.1016/J.Chom.2019.04.005 |
0.405 |
|
| 2019 |
Lee W, Tonelli M, Wu C, Aceti DJ, Amarasinghe GK, Markley JL. Backbone resonance assignments and secondary structure of Ebola nucleoprotein 600-739 construct. Biomolecular Nmr Assignments. PMID 31076990 DOI: 10.1007/S12104-019-09898-7 |
0.459 |
|
| 2019 |
Kuhn JH, Amarasinghe GK, Basler CF, Bavari S, Bukreyev A, Chandran K, Crozier I, Dolnik O, Dye JM, Formenty PBH, Griffiths A, Hewson R, Kobinger GP, Leroy EM, Mühlberger E, et al. ICTV Virus Taxonomy Profile: Filoviridae. The Journal of General Virology. PMID 31021739 DOI: 10.1099/Jgv.0.001252 |
0.434 |
|
| 2019 |
Chen G, Karauzum H, Long H, Carranza D, Holtsberg FW, Howell KA, Abaandou L, Zhang B, Jarvik N, Ye W, Liao GC, Gross ML, Leung DW, Amarasinghe GK, Aman MJ, et al. Potent Neutralization of Staphylococcal Enterotoxin B in vivo by Antibodies that Block Binding to the T-Cell Receptor. Journal of Molecular Biology. PMID 30928493 DOI: 10.1016/J.Jmb.2019.03.017 |
0.612 |
|
| 2018 |
Knoverek CR, Amarasinghe GK, Bowman GR. Advanced Methods for Accessing Protein Shape-Shifting Present New Therapeutic Opportunities. Trends in Biochemical Sciences. PMID 30555007 DOI: 10.1016/J.Tibs.2018.11.007 |
0.333 |
|
| 2018 |
Basler CF, Krogan NJ, Leung DW, Amarasinghe GK. Virus and host interactions critical for filoviral RNA synthesis as therapeutic targets. Antiviral Research. PMID 30550800 DOI: 10.1016/J.Antiviral.2018.12.006 |
0.741 |
|
| 2018 |
Batra J, Hultquist JF, Liu D, Shtanko O, Von Dollen J, Satkamp L, Jang GM, Luthra P, Schwarz TM, Small GI, Arnett E, Anantpadma M, Reyes A, Leung DW, Kaake R, ... ... Amarasinghe GK, et al. Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication. Cell. 175: 1917-1930.e13. PMID 30550789 DOI: 10.1016/J.Cell.2018.08.044 |
0.725 |
|
| 2018 |
Johnston AB, Hilton DM, McConnell P, Johnson B, Harris MT, Simone A, Amarasinghe GK, Cooper JA, Goode BL. A novel mode of Capping Protein-regulation by Twinfilin. Elife. 7. PMID 30351272 DOI: 10.7554/Elife.41313 |
0.385 |
|
| 2018 |
Edwards MR, Liu H, Shabman RS, Ginell GM, Luthra P, Ramanan P, Keefe LJ, Köllner B, Amarasinghe GK, Taylor DJ, Leung DW, Basler CF. Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes. Cell Reports. 24: 861-872.e6. PMID 30044983 DOI: 10.1016/J.Celrep.2018.06.045 |
0.713 |
|
| 2018 |
Klein RD, Shu Q, Cusumano ZT, Nagamatsu K, Gualberto NC, Lynch AJL, Wu C, Wang W, Jain N, Pinkner JS, Amarasinghe GK, Hultgren SJ, Frieden C, Chapman MR. Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation. Mbio. 9. PMID 30018113 DOI: 10.1128/Mbio.01349-18 |
0.309 |
|
| 2018 |
Warfield KL, Howell KA, Vu H, Geisbert J, Wong G, Shulenin S, Sproule S, Holtsberg FW, Leung DW, Amarasinghe GK, Swenson DL, Bavari S, Kobinger GP, Geisbert TW, Aman MJ. Role of Antibodies in Protection Against Ebola Virus in Nonhuman Primates Immunized With Three Vaccine Platforms. The Journal of Infectious Diseases. PMID 29939318 DOI: 10.1093/Infdis/Jiy316 |
0.612 |
|
| 2018 |
Johnson B, McConnell P, Kozlov AG, Mekel M, Lohman TM, Gross ML, Amarasinghe GK, Cooper JA. Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein Revealed by Hydrogen-Deuterium Exchange. Cell Reports. 23: 2795-2804. PMID 29847807 DOI: 10.1016/J.Celrep.2018.04.096 |
0.324 |
|
| 2018 |
Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK. Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Immunity. PMID 29525521 DOI: 10.1016/J.Immuni.2018.01.014 |
0.708 |
|
| 2018 |
Yokoyama CC, Baldridge MT, Leung DW, Zhao G, Desai C, Liu TC, Diaz-Ochoa VE, Huynh JP, Kimmey JM, Sennott EL, Hole CR, Idol RA, Park S, Storek KM, Wang C, ... ... Amarasinghe GK, et al. LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens. The Journal of Biological Chemistry. PMID 29496999 DOI: 10.1074/Jbc.Ra117.001246 |
0.663 |
|
| 2018 |
Su Z, Wu C, Shi L, Luthra P, Pintilie GD, Johnson B, Porter JR, Ge P, Chen M, Liu G, Frederick TE, Binning JM, Bowman GR, Zhou ZH, Basler CF, ... ... Amarasinghe GK, et al. Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly. Cell. 172: 966-978.e12. PMID 29474922 DOI: 10.1016/J.Cell.2018.02.009 |
0.798 |
|
| 2018 |
Williams GD, Townsend D, Wylie KM, Kim PJ, Amarasinghe GK, Kutluay SB, Boon ACM. Nucleotide resolution mapping of influenza A virus nucleoprotein-RNA interactions reveals RNA features required for replication. Nature Communications. 9: 465. PMID 29386621 DOI: 10.1038/S41467-018-02886-W |
0.451 |
|
| 2017 |
Holze C, Michaudel C, Mackowiak C, Haas DA, Benda C, Hubel P, Pennemann FL, Schnepf D, Wettmarshausen J, Braun M, Leung DW, Amarasinghe GK, Perocchi F, Staeheli P, Ryffel B, et al. Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway. Nature Immunology. PMID 29255269 DOI: 10.1038/S41590-017-0013-Y |
0.615 |
|
| 2017 |
Kirchdoerfer RN, Wasserman H, Amarasinghe GK, Saphire EO. Filovirus Structural Biology: The Molecules in the Machine. Current Topics in Microbiology and Immunology. PMID 28795188 DOI: 10.1007/82_2017_16 |
0.377 |
|
| 2017 |
Olejnik J, Hume AJ, Leung DW, Amarasinghe GK, Basler CF, Mühlberger E. Filovirus Strategies to Escape Antiviral Responses. Current Topics in Microbiology and Immunology. PMID 28685291 DOI: 10.1007/82_2017_13 |
0.673 |
|
| 2017 |
Chatterjee S, Luthra P, Esaulova E, Agapov E, Yen BC, Borek DM, Edwards MR, Mittal A, Jordan DS, Ramanan P, Moore ML, Pappu RV, Holtzman MJ, Artyomov MN, Basler CF, ... Amarasinghe GK, et al. Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses. Nature Microbiology. 2: 17101. PMID 28665409 DOI: 10.1038/Nmicrobiol.2017.101 |
0.708 |
|
| 2017 |
Xu W, Luthra P, Wu C, Batra J, Leung DW, Basler CF, Amarasinghe GK. Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis. Nature Communications. 8: 15576. PMID 28593988 DOI: 10.1038/Ncomms15576 |
0.722 |
|
| 2017 |
Liu G, Nash PJ, Johnson B, Pietzsch C, Ilagan MG, Bukreyev A, Basler CF, Bowlin TL, Moir DT, Leung DW, Amarasinghe GK. A Sensitive In Vitro High-Throughput Screen to Identify Pan-Filoviral Replication Inhibitors Targeting the VP35-NP Interface. Acs Infectious Diseases. PMID 28152588 DOI: 10.1021/Acsinfecdis.6B00209 |
0.687 |
|
| 2017 |
Ginell GM, Amarasinghe GK, Basler CF, Keefe LJ, Leung DW. Structural studies of ebola viral homolog encoded by microbats Acta Crystallographica Section a Foundations and Advances. 73: a273-a273. DOI: 10.1107/S0108767317097318 |
0.675 |
|
| 2016 |
Schwarz TM, Edwards MR, Diederichs A, Alinger JB, Leung DW, Amarasinghe GK, Basler CF. VP24-karyopherin alpha binding affinities differ between Ebolavirus species influencing interferon inhibition and VP24 stability. Journal of Virology. PMID 27974555 DOI: 10.1128/Jvi.01715-16 |
0.673 |
|
| 2016 |
Postler TS, Clawson AN, Amarasinghe GK, Basler CF, Bavari S, Benkő M, Blasdell KR, Briese T, Buchmeier MJ, Bukreyev A, Calisher CH, Chandran K, Charrel R, Clegg CS, Collins PL, et al. Possibility and Challenges of Conversion of Current Virus Species Names to Linnaean Binomials. Systematic Biology. PMID 27798405 DOI: 10.1093/Sysbio/Syw096 |
0.328 |
|
| 2016 |
Johnson B, Li J, Adhikari J, Edwards MR, Zhang H, Schwarz T, Leung DW, Basler CF, Gross ML, Amarasinghe GK. Dimerization controls Marburg virus VP24-dependent modulation of host antioxidative stress responses. Journal of Molecular Biology. PMID 27497688 DOI: 10.1016/J.Jmb.2016.07.020 |
0.717 |
|
| 2016 |
Chatterjee S, Basler CF, Amarasinghe GK, Leung DW. Molecular mechanisms of innate immune inhibition by non-segmented negative-sense RNA viruses. Journal of Molecular Biology. PMID 27487481 DOI: 10.1016/J.Jmb.2016.07.017 |
0.716 |
|
| 2016 |
Leung DW, Amarasinghe GK. When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins. Current Opinion in Structural Biology. 36: 133-141. PMID 26916433 DOI: 10.1016/J.Sbi.2016.02.001 |
0.681 |
|
| 2016 |
Edwards MR, Liu G, Mire CE, Sureshchandra S, Luthra P, Yen B, Shabman RS, Leung DW, Messaoudi I, Geisbert TW, Amarasinghe GK, Basler CF. Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins. Cell Reports. PMID 26876165 DOI: 10.1016/J.Celrep.2016.01.049 |
0.723 |
|
| 2015 |
Messaoudi I, Amarasinghe GK, Basler CF. Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus. Nature Reviews. Microbiology. 13: 663-76. PMID 26439085 DOI: 10.1038/Nrmicro3524 |
0.463 |
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| 2015 |
Pinto AK, Williams GD, Szretter KJ, White JP, Proença-Módena JL, Liu G, Olejnik J, Brien JD, Ebihara H, Mühlberger E, Amarasinghe G, Diamond MS, Boon AC. Human and Murine IFIT1 Proteins Do Not Restrict Infection of Negative-Sense RNA Viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae Families. Journal of Virology. 89: 9465-76. PMID 26157117 DOI: 10.1128/Jvi.00996-15 |
0.5 |
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| 2015 |
Leung DW, Borek D, Luthra P, Binning JM, Anantpadma M, Liu G, Harvey IB, Su Z, Endlich-Frazier A, Pan J, Shabman RS, Chiu W, Davey RA, Otwinowski Z, Basler CF, ... Amarasinghe GK, et al. An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions. Cell Reports. 11: 376-89. PMID 25865894 DOI: 10.1016/J.Celrep.2015.03.034 |
0.802 |
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| 2015 |
Korasick DA, Chatterjee S, Tonelli M, Dashti H, Lee SG, Westfall CS, Fulton DB, Andreotti AH, Amarasinghe GK, Strader LC, Jez JM. Defining a two-pronged structural model for PB1 (Phox/Bem1p) domain interaction in plant auxin responses. The Journal of Biological Chemistry. 290: 12868-78. PMID 25839233 DOI: 10.1074/Jbc.M115.648253 |
0.366 |
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| 2015 |
Luthra P, Jordan DS, Leung DW, Amarasinghe GK, Basler CF. Ebola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis. Journal of Virology. 89: 5148-53. PMID 25741013 DOI: 10.1128/Jvi.03652-14 |
0.715 |
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| 2014 |
Xu W, Edwards MR, Borek DM, Feagins AR, Mittal A, Alinger JB, Berry KN, Yen B, Hamilton J, Brett TJ, Pappu RV, Leung DW, Basler CF, Amarasinghe GK. Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1. Cell Host & Microbe. 16: 187-200. PMID 25121748 DOI: 10.1016/J.Chom.2014.07.008 |
0.668 |
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| 2014 |
Edwards MR, Johnson B, Mire CE, Xu W, Shabman RS, Speller LN, Leung DW, Geisbert TW, Amarasinghe GK, Basler CF. The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway. Cell Reports. 6: 1017-25. PMID 24630991 DOI: 10.1016/J.Celrep.2014.01.043 |
0.696 |
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| 2014 |
Brown CS, Lee MS, Leung DW, Wang T, Xu W, Luthra P, Anantpadma M, Shabman RS, Melito LM, MacMillan KS, Borek DM, Otwinowski Z, Ramanan P, Stubbs AJ, Peterson DS, ... ... Amarasinghe GK, et al. In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity. Journal of Molecular Biology. 426: 2045-58. PMID 24495995 DOI: 10.1016/J.Jmb.2014.01.010 |
0.837 |
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| 2014 |
Hyde JL, Gardner CL, Kimura T, White JP, Liu G, Trobaugh DW, Huang C, Tonelli M, Paessler S, Takeda K, Klimstra WB, Amarasinghe GK, Diamond MS. A viral RNA structural element alters host recognition of nonself RNA. Science (New York, N.Y.). 343: 783-7. PMID 24482115 DOI: 10.1126/Science.1248465 |
0.474 |
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| 2014 |
Amarasinghe GK, Dutch RE. A calcium-fortified viral matrix protein. Structure (London, England : 1993). 22: 5-7. PMID 24411575 DOI: 10.1016/J.Str.2013.12.008 |
0.363 |
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| 2013 |
Binning JM, Wang T, Luthra P, Shabman RS, Borek DM, Liu G, Xu W, Leung DW, Basler CF, Amarasinghe GK. Development of RNA aptamers targeting Ebola virus VP35 Biochemistry. 52: 8406-8419. PMID 24067086 DOI: 10.1021/Bi400704D |
0.83 |
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| 2013 |
Luthra P, Ramanan P, Mire CE, Weisend C, Tsuda Y, Yen B, Liu G, Leung DW, Geisbert TW, Ebihara H, Amarasinghe GK, Basler CF. Mutual antagonism between the ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome Cell Host and Microbe. 14: 74-84. PMID 23870315 DOI: 10.1016/J.Chom.2013.06.010 |
0.737 |
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| 2013 |
Shabman RS, Hoenen T, Groseth A, Jabado O, Binning JM, Amarasinghe GK, Feldmann H, Basler CF. An upstream open reading frame modulates ebola virus polymerase translation and virus replication. Plos Pathogens. 9: e1003147. PMID 23382680 DOI: 10.1371/Journal.Ppat.1003147 |
0.792 |
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| 2012 |
Ramanan P, Edwards MR, Shabman RS, Leung DW, Endlich-Frazier AC, Borek DM, Otwinowski Z, Liu G, Huh J, Basler CF, Amarasinghe GK. Structural basis for Marburg virus VP35-mediated immune evasion mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 109: 20661-20666. PMID 23185024 DOI: 10.1073/Pnas.1213559109 |
0.722 |
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| 2012 |
Leung DW, Amarasinghe GK. Structural insights into RNA recognition and activation of RIG-I-like receptors Current Opinion in Structural Biology. 22: 297-303. PMID 22560447 DOI: 10.1016/J.Sbi.2012.03.011 |
0.713 |
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| 2012 |
Binning JM, Leung DW, Amarasinghe GK. Aptamers in virology: recent advances and challenges. Frontiers in Microbiology. 3: 29. PMID 22347221 DOI: 10.3389/Fmicb.2012.00029 |
0.779 |
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| 2012 |
Leung DW, Basler CF, Amarasinghe GK. Molecular mechanisms of viral inhibitors of RIG-I-like receptors Trends in Microbiology. 20: 139-146. PMID 22325030 DOI: 10.1016/J.Tim.2011.12.005 |
0.705 |
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| 2012 |
Binning JM, Leung DW, Amarasinghe GK. Aptamers in virology: Recent advances and challenges Frontiers in Microbiology. 3. DOI: 10.3389/fmicb.2012.00029 |
0.76 |
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| 2011 |
Ramanan P, Shabman RS, Brown CS, Amarasinghe GK, Basler CF, Leung DW. Filoviral immune evasion mechanisms Viruses. 3: 1634-1649. PMID 21994800 DOI: 10.3390/V3091634 |
0.681 |
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| 2011 |
Shabman RS, Leung DW, Johnson J, Glennon N, Gulcicek EE, Stone KL, Leung L, Hensley L, Amarasinghe GK, Basler CF. DRBP76 associates with Ebola virus VP35 and suppresses viral polymerase function. The Journal of Infectious Diseases. 204: S911-8. PMID 21987769 DOI: 10.1093/Infdis/Jir343 |
0.741 |
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| 2010 |
Leung DW, Prins KC, Basler CF, Amarasinghe GK. Ebolavirus VP35 is a multifunctional virulence factor Virulence. 1: 526-531. PMID 21178490 DOI: 10.4161/Viru.1.6.12984 |
0.738 |
|
| 2010 |
Prins KC, Binning JM, Shabman RS, Leung DW, Amarasinghe GK, Basler CF. Basic residues within the ebolavirus VP35 protein are required for its viral polymerase cofactor function Journal of Virology. 84: 10581-10591. PMID 20686031 DOI: 10.1128/Jvi.00925-10 |
0.822 |
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| 2010 |
Leung DW, Borek D, Farahbakhsh M, Ramanan P, Nix JC, Wang T, Prins KC, Otwinowski Z, Honzatko RB, Helgeson LA, Basler CF, Amarasinghe GK. Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 66: 689-692. PMID 20516601 DOI: 10.1107/S1744309110013266 |
0.683 |
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| 2010 |
Leung DW, Shabman RS, Farahbakhsh M, Prins KC, Borek DM, Wang T, Mühlberger E, Basler CF, Amarasinghe GK. Structural and functional characterization of Reston Ebola virus VP35 interferon inhibitory domain Journal of Molecular Biology. 399: 347-357. PMID 20399790 DOI: 10.1016/J.Jmb.2010.04.022 |
0.739 |
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| 2010 |
Yu B, Martins IR, Li P, Amarasinghe GK, Umetani J, Fernandez-Zapico ME, Billadeau DD, Machius M, Tomchick DR, Rosen MK. Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell. 140: 246-56. PMID 20141838 DOI: 10.1107/S0108767311097042 |
0.723 |
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| 2010 |
Leung DW, Prins KC, Borek DM, Farahbakhsh M, Tufariello JM, Ramanan P, Nix JC, Helgeson LA, Otwinowski Z, Honzatko RB, Basler CF, Amarasinghe GK. Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35 Nature Structural and Molecular Biology. 17: 165-172. PMID 20081868 DOI: 10.1038/Nsmb.1765 |
0.735 |
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| 2010 |
Prins KC, Delpeut S, Leung DW, Reynard O, Volchkova VA, Reid SP, Ramanan P, Cárdenas WB, Amarasinghe GK, Volchkov VE, Basler CF. Mutations abrogating VP35 interaction with double-stranded RNA render Ebola virus avirulent in guinea pigs Journal of Virology. 84: 3004-3015. PMID 20071589 DOI: 10.1128/Jvi.02459-09 |
0.724 |
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| 2009 |
Basler CF, Amarasinghe GK. Evasion of interferon responses by Ebola and Marburg viruses. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 29: 511-20. PMID 19694547 DOI: 10.1089/Jir.2009.0076 |
0.517 |
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| 2009 |
Leung DW, Ginder ND, Nix JC, Basler CF, Honzatko RB, Amarasinghe GK. Expression, purification, crystallization and preliminary X-ray studies of the Ebola VP35 interferon inhibitory domain Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 65: 163-165. PMID 19194011 DOI: 10.1107/S1744309108044187 |
0.639 |
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| 2009 |
Leung DW, Ginder ND, Fulton DB, Nix J, Basler CF, Honzatko RB, Amarasinghe GK. Structure of the Ebola VP35 interferon inhibitory domain Proceedings of the National Academy of Sciences of the United States of America. 106: 411-416. PMID 19122151 DOI: 10.1073/Pnas.0807854106 |
0.72 |
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| 2009 |
Rosen MK, Li P, Martins IR, Amarasinghe GK, Yu B, Umetani J. Dynamic Origins of Interdomain Cooperativity in the Vav1 Proto-Oncoprotein Biophysical Journal. 96: 3a. DOI: 10.1016/J.Bpj.2008.12.907 |
0.727 |
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| 2008 |
Li P, Martins IR, Amarasinghe GK, Rosen MK. Internal dynamics control activation and activity of the autoinhibited Vav DH domain. Nature Structural & Molecular Biology. 15: 613-8. PMID 18488041 DOI: 10.1038/Nsmb.1428 |
0.714 |
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| 2005 |
Amarasinghe GK, Rosen MK. Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain. Biochemistry. 44: 15257-68. PMID 16285729 DOI: 10.1021/Bi051126H |
0.525 |
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| 2003 |
Gelhaus SL, LaCourse WR, Hagan NA, Amarasinghe GK, Fabris D. Rapid purification of RNA secondary structures. Nucleic Acids Research. 31: e135. PMID 14576335 DOI: 10.1093/Nar/Gng136 |
0.325 |
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| 2001 |
Amarasinghe GK, Zhou J, Miskimon M, Chancellor KJ, McDonald JA, Matthews AG, Miller RR, Rouse MD, Summers MF. Stem-loop SL4 of the HIV-1 psi RNA packaging signal exhibits weak affinity for the nucleocapsid protein. structural studies and implications for genome recognition. Journal of Molecular Biology. 314: 961-70. PMID 11743714 DOI: 10.1006/Jmbi.2000.5182 |
0.397 |
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| 2000 |
Amarasinghe GK, De Guzman RN, Turner RB, Chancellor KJ, Wu ZR, Summers MF. NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop SL2 of the psi-RNA packaging signal. Implications for genome recognition. Journal of Molecular Biology. 301: 491-511. PMID 10926523 DOI: 10.1006/Jmbi.2000.3979 |
0.413 |
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| 2000 |
Amarasinghe GK, De Guzman RN, Turner RB, Summers MF. NMR structure of stem-loop SL2 of the HIV-1 psi RNA packaging signal reveals a novel A-U-A base-triple platform. Journal of Molecular Biology. 299: 145-56. PMID 10860728 DOI: 10.1006/Jmbi.2000.3710 |
0.338 |
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