Gaya K. Amarasinghe - Publications

Affiliations: 
Biochemistry, Biophysics, and Molecular Biology Iowa State University, Ames, IA, United States 
Area:
Virology Biology

62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wang W, Wu C, Amarasinghe GK, Leung DW. Ebola Virus Replication Stands Out. Trends in Microbiology. PMID 31155428 DOI: 10.1016/j.tim.2019.05.004  0.36
2019 Amarasinghe GK, Ayllón MA, Bào Y, Basler CF, Bavari S, Blasdell KR, Briese T, Brown PA, Bukreyev A, Balkema-Buschmann A, Buchholz UJ, Chabi-Jesus C, Chandran K, Chiapponi C, Crozier I, et al. Taxonomy of the order Mononegavirales: update 2019. Archives of Virology. PMID 31089958 DOI: 10.1007/s00705-019-04247-4  0.32
2019 Kuhn JH, Amarasinghe GK, Basler CF, Bavari S, Bukreyev A, Chandran K, Crozier I, Dolnik O, Dye JM, Formenty PBH, Griffiths A, Hewson R, Kobinger GP, Leroy EM, Mühlberger E, et al. ICTV Virus Taxonomy Profile: Filoviridae. The Journal of General Virology. PMID 31021739 DOI: 10.1099/jgv.0.001252  0.32
2019 Chen G, Karauzum H, Long H, Carranza D, Holtsberg FW, Howell KA, Abaandou L, Zhang B, Jarvik N, Ye W, Liao GC, Gross ML, Leung DW, Amarasinghe GK, Aman MJ, et al. Potent Neutralization of Staphylococcal Enterotoxin B in vivo by Antibodies that Block Binding to the T-Cell Receptor. Journal of Molecular Biology. PMID 30928493 DOI: 10.1016/j.jmb.2019.03.017  0.36
2019 Maes P, Amarasinghe GK, Ayllón MA, Basler CF, Bavari S, Blasdell KR, Briese T, Brown PA, Bukreyev A, Balkema-Buschmann A, Buchholz UJ, Chandran K, Crozier I, de Swart RL, Dietzgen RG, et al. Taxonomy of the order Mononegavirales: second update 2018. Archives of Virology. PMID 30663023 DOI: 10.1007/s00705-018-04126-4  0.32
2018 Basler CF, Krogan NJ, Leung DW, Amarasinghe GK. Virus and host interactions critical for filoviral RNA synthesis as therapeutic targets. Antiviral Research. PMID 30550800 DOI: 10.1016/j.antiviral.2018.12.006  0.36
2018 Batra J, Hultquist JF, Liu D, Shtanko O, Von Dollen J, Satkamp L, Jang GM, Luthra P, Schwarz TM, Small GI, Arnett E, Anantpadma M, Reyes A, Leung DW, Kaake R, ... ... Amarasinghe GK, et al. Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication. Cell. 175: 1917-1930.e13. PMID 30550789 DOI: 10.1016/j.cell.2018.08.044  0.36
2018 Edwards MR, Liu H, Shabman RS, Ginell GM, Luthra P, Ramanan P, Keefe LJ, Köllner B, Amarasinghe GK, Taylor DJ, Leung DW, Basler CF. Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes. Cell Reports. 24: 861-872.e6. PMID 30044983 DOI: 10.1016/j.celrep.2018.06.045  0.36
2018 Warfield KL, Howell KA, Vu H, Geisbert J, Wong G, Shulenin S, Sproule S, Holtsberg FW, Leung DW, Amarasinghe GK, Swenson DL, Bavari S, Kobinger GP, Geisbert TW, Aman MJ. Role of Antibodies in Protection Against Ebola Virus in Nonhuman Primates Immunized With Three Vaccine Platforms. The Journal of Infectious Diseases. PMID 29939318 DOI: 10.1093/infdis/jiy316  0.36
2018 Amarasinghe GK, Aréchiga Ceballos NG, Banyard AC, Basler CF, Bavari S, Bennett AJ, Blasdell KR, Briese T, Bukreyev A, Caì Y, Calisher CH, Campos Lawson C, Chandran K, Chapman CA, Chiu CY, et al. Taxonomy of the order Mononegavirales: update 2018. Archives of Virology. PMID 29637429 DOI: 10.1007/s00705-018-3814-x  0.32
2018 Johnson B, VanBlargan LA, Xu W, White JP, Shan C, Shi PY, Zhang R, Adhikari J, Gross ML, Leung DW, Diamond MS, Amarasinghe GK. Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Immunity. PMID 29525521 DOI: 10.1016/j.immuni.2018.01.014  0.36
2018 Yokoyama CC, Baldridge MT, Leung DW, Zhao G, Desai C, Liu TC, Diaz-Ochoa VE, Huynh JP, Kimmey JM, Sennott EL, Hole CR, Idol RA, Park S, Storek KM, Wang C, ... ... Amarasinghe GK, et al. LysMD3 is a type II membrane protein without an in vivo role in the response to a range of pathogens. The Journal of Biological Chemistry. PMID 29496999 DOI: 10.1074/jbc.RA117.001246  0.36
2018 Su Z, Wu C, Shi L, Luthra P, Pintilie GD, Johnson B, Porter JR, Ge P, Chen M, Liu G, Frederick TE, Binning JM, Bowman GR, Zhou ZH, Basler CF, ... ... Amarasinghe GK, et al. Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly. Cell. 172: 966-978.e12. PMID 29474922 DOI: 10.1016/j.cell.2018.02.009  0.36
2017 Holze C, Michaudel C, Mackowiak C, Haas DA, Benda C, Hubel P, Pennemann FL, Schnepf D, Wettmarshausen J, Braun M, Leung DW, Amarasinghe GK, Perocchi F, Staeheli P, Ryffel B, et al. Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway. Nature Immunology. PMID 29255269 DOI: 10.1038/s41590-017-0013-y  0.36
2017 Olejnik J, Hume AJ, Leung DW, Amarasinghe GK, Basler CF, Mühlberger E. Filovirus Strategies to Escape Antiviral Responses. Current Topics in Microbiology and Immunology. PMID 28685291 DOI: 10.1007/82_2017_13  0.36
2017 Chatterjee S, Luthra P, Esaulova E, Agapov E, Yen BC, Borek DM, Edwards MR, Mittal A, Jordan DS, Ramanan P, Moore ML, Pappu RV, Holtzman MJ, Artyomov MN, Basler CF, ... Amarasinghe GK, et al. Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses. Nature Microbiology. 2: 17101. PMID 28665409 DOI: 10.1038/nmicrobiol.2017.101  0.36
2017 Xu W, Luthra P, Wu C, Batra J, Leung DW, Basler CF, Amarasinghe GK. Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis. Nature Communications. 8: 15576. PMID 28593988 DOI: 10.1038/ncomms15576  0.36
2017 Bào Y, Amarasinghe GK, Basler CF, Bavari S, Bukreyev A, Chandran K, Dolnik O, Dye JM, Ebihara H, Formenty P, Hewson R, Kobinger GP, Leroy EM, Mühlberger E, Netesov SV, et al. Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses. Viruses. 9. PMID 28492506 DOI: 10.3390/v9050106  0.32
2017 Amarasinghe GK, Bào Y, Basler CF, Bavari S, Beer M, Bejerman N, Blasdell KR, Bochnowski A, Briese T, Bukreyev A, Calisher CH, Chandran K, Collins PL, Dietzgen RG, Dolnik O, et al. Taxonomy of the order Mononegavirales: update 2017. Archives of Virology. PMID 28389807 DOI: 10.1007/s00705-017-3311-7  0.32
2017 Liu G, Nash PJ, Johnson B, Pietzsch C, Ilagan MG, Bukreyev A, Basler CF, Bowlin TL, Moir DT, Leung DW, Amarasinghe GK. A Sensitive In Vitro High-Throughput Screen to Identify Pan-Filoviral Replication Inhibitors Targeting the VP35-NP Interface. Acs Infectious Diseases. PMID 28152588 DOI: 10.1021/acsinfecdis.6b00209  0.36
2016 Schwarz TM, Edwards MR, Diederichs A, Alinger JB, Leung DW, Amarasinghe GK, Basler CF. VP24-karyopherin alpha binding affinities differ between Ebolavirus species influencing interferon inhibition and VP24 stability. Journal of Virology. PMID 27974555 DOI: 10.1128/JVI.01715-16  0.36
2016 Postler TS, Clawson AN, Amarasinghe GK, Basler CF, Bavari S, Benkő M, Blasdell KR, Briese T, Buchmeier MJ, Bukreyev A, Calisher CH, Chandran K, Charrel R, Clegg CS, Collins PL, et al. Possibility and Challenges of Conversion of Current Virus Species Names to Linnaean Binomials. Systematic Biology. PMID 27798405 DOI: 10.1093/sysbio/syw096  0.32
2016 Johnson B, Li J, Adhikari J, Edwards MR, Zhang H, Schwarz T, Leung DW, Basler CF, Gross ML, Amarasinghe GK. Dimerization controls Marburg virus VP24-dependent modulation of host antioxidative stress responses. Journal of Molecular Biology. PMID 27497688 DOI: 10.1016/j.jmb.2016.07.020  0.36
2016 Chatterjee S, Basler CF, Amarasinghe GK, Leung DW. Molecular mechanisms of innate immune inhibition by non-segmented negative-sense RNA viruses. Journal of Molecular Biology. PMID 27487481 DOI: 10.1016/j.jmb.2016.07.017  0.36
2016 Afonso CL, Amarasinghe GK, Bányai K, Bào Y, Basler CF, Bavari S, Bejerman N, Blasdell KR, Briand FX, Briese T, Bukreyev A, Calisher CH, Chandran K, Chéng J, Clawson AN, et al. Taxonomy of the order Mononegavirales: update 2016. Archives of Virology. PMID 27216929 DOI: 10.1007/s00705-016-2880-1  0.36
2016 Leung DW, Amarasinghe GK. When your cap matters: structural insights into self vs non-self recognition of 5' RNA by immunomodulatory host proteins. Current Opinion in Structural Biology. 36: 133-141. PMID 26916433 DOI: 10.1016/j.sbi.2016.02.001  0.36
2016 Edwards MR, Liu G, Mire CE, Sureshchandra S, Luthra P, Yen B, Shabman RS, Leung DW, Messaoudi I, Geisbert TW, Amarasinghe GK, Basler CF. Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins. Cell Reports. PMID 26876165 DOI: 10.1016/j.celrep.2016.01.049  0.36
2015 Messaoudi I, Amarasinghe GK, Basler CF. Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus. Nature Reviews. Microbiology. 13: 663-76. PMID 26439085 DOI: 10.1038/nrmicro3524  0.36
2015 Leung DW, Borek D, Luthra P, Binning JM, Anantpadma M, Liu G, Harvey IB, Su Z, Endlich-Frazier A, Pan J, Shabman RS, Chiu W, Davey RA, Otwinowski Z, Basler CF, ... Amarasinghe GK, et al. An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions. Cell Reports. 11: 376-89. PMID 25865894 DOI: 10.1016/j.celrep.2015.03.034  0.36
2015 Korasick DA, Chatterjee S, Tonelli M, Dashti H, Lee SG, Westfall CS, Fulton DB, Andreotti AH, Amarasinghe GK, Strader LC, Jez JM. Defining a two-pronged structural model for PB1 (Phox/Bem1p) domain interaction in plant auxin responses. The Journal of Biological Chemistry. 290: 12868-78. PMID 25839233 DOI: 10.1074/jbc.M115.648253  0.36
2015 Luthra P, Jordan DS, Leung DW, Amarasinghe GK, Basler CF. Ebola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis. Journal of Virology. 89: 5148-53. PMID 25741013 DOI: 10.1128/JVI.03652-14  0.36
2014 Xu W, Edwards MR, Borek DM, Feagins AR, Mittal A, Alinger JB, Berry KN, Yen B, Hamilton J, Brett TJ, Pappu RV, Leung DW, Basler CF, Amarasinghe GK. Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1. Cell Host & Microbe. 16: 187-200. PMID 25121748 DOI: 10.1016/j.chom.2014.07.008  0.36
2014 Edwards MR, Johnson B, Mire CE, Xu W, Shabman RS, Speller LN, Leung DW, Geisbert TW, Amarasinghe GK, Basler CF. The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway. Cell Reports. 6: 1017-25. PMID 24630991 DOI: 10.1016/j.celrep.2014.01.043  0.36
2014 Brown CS, Lee MS, Leung DW, Wang T, Xu W, Luthra P, Anantpadma M, Shabman RS, Melito LM, MacMillan KS, Borek DM, Otwinowski Z, Ramanan P, Stubbs AJ, Peterson DS, ... ... Amarasinghe GK, et al. In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity. Journal of Molecular Biology. 426: 2045-58. PMID 24495995 DOI: 10.1016/j.jmb.2014.01.010  0.36
2014 Hyde JL, Gardner CL, Kimura T, White JP, Liu G, Trobaugh DW, Huang C, Tonelli M, Paessler S, Takeda K, Klimstra WB, Amarasinghe GK, Diamond MS. A viral RNA structural element alters host recognition of nonself RNA. Science (New York, N.Y.). 343: 783-7. PMID 24482115 DOI: 10.1126/science.1248465  0.36
2014 Amarasinghe GK, Dutch RE. A calcium-fortified viral matrix protein. Structure (London, England : 1993). 22: 5-7. PMID 24411575 DOI: 10.1016/j.str.2013.12.008  0.36
2013 Binning JM, Wang T, Luthra P, Shabman RS, Borek DM, Liu G, Xu W, Leung DW, Basler CF, Amarasinghe GK. Development of RNA aptamers targeting Ebola virus VP35 Biochemistry. 52: 8406-8419. PMID 24067086 DOI: 10.1021/bi400704d  0.36
2013 Luthra P, Ramanan P, Mire CE, Weisend C, Tsuda Y, Yen B, Liu G, Leung DW, Geisbert TW, Ebihara H, Amarasinghe GK, Basler CF. Mutual antagonism between the ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome Cell Host and Microbe. 14: 74-84. PMID 23870315 DOI: 10.1016/j.chom.2013.06.010  0.36
2013 Shabman RS, Hoenen T, Groseth A, Jabado O, Binning JM, Amarasinghe GK, Feldmann H, Basler CF. An upstream open reading frame modulates ebola virus polymerase translation and virus replication. Plos Pathogens. 9: e1003147. PMID 23382680 DOI: 10.1371/journal.ppat.1003147  0.36
2012 Ramanan P, Edwards MR, Shabman RS, Leung DW, Endlich-Frazier AC, Borek DM, Otwinowski Z, Liu G, Huh J, Basler CF, Amarasinghe GK. Structural basis for Marburg virus VP35-mediated immune evasion mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 109: 20661-20666. PMID 23185024  0.36
2012 Leung DW, Amarasinghe GK. Structural insights into RNA recognition and activation of RIG-I-like receptors Current Opinion in Structural Biology. 22: 297-303. PMID 22560447 DOI: 10.1016/j.sbi.2012.03.011  0.36
2012 Binning JM, Leung DW, Amarasinghe GK. Aptamers in virology: recent advances and challenges. Frontiers in Microbiology. 3: 29. PMID 22347221 DOI: 10.3389/fmicb.2012.00029  0.36
2012 Leung DW, Basler CF, Amarasinghe GK. Molecular mechanisms of viral inhibitors of RIG-I-like receptors Trends in Microbiology. 20: 139-146. PMID 22325030 DOI: 10.1016/j.tim.2011.12.005  0.36
2012 Binning JM, Leung DW, Amarasinghe GK. Aptamers in virology: Recent advances and challenges Frontiers in Microbiology. 3. DOI: 10.3389/fmicb.2012.00029  0.36
2011 Ramanan P, Shabman RS, Brown CS, Amarasinghe GK, Basler CF, Leung DW. Filoviral immune evasion mechanisms Viruses. 3: 1634-1649. PMID 21994800 DOI: 10.3390/v3091634  0.36
2011 Shabman RS, Leung DW, Johnson J, Glennon N, Gulcicek EE, Stone KL, Leung L, Hensley L, Amarasinghe GK, Basler CF. DRBP76 associates with Ebola virus VP35 and suppresses viral polymerase function. The Journal of Infectious Diseases. 204: S911-8. PMID 21987769 DOI: 10.1093/infdis/jir343  0.36
2010 Leung DW, Prins KC, Basler CF, Amarasinghe GK. Ebolavirus VP35 is a multifunctional virulence factor Virulence. 1: 526-531. PMID 21178490 DOI: 10.4161/viru.1.6.12984  0.36
2010 Prins KC, Binning JM, Shabman RS, Leung DW, Amarasinghe GK, Basler CF. Basic residues within the ebolavirus VP35 protein are required for its viral polymerase cofactor function Journal of Virology. 84: 10581-10591. PMID 20686031 DOI: 10.1128/JVI.00925-10  0.36
2010 Leung DW, Borek D, Farahbakhsh M, Ramanan P, Nix JC, Wang T, Prins KC, Otwinowski Z, Honzatko RB, Helgeson LA, Basler CF, Amarasinghe GK. Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 66: 689-692. PMID 20516601 DOI: 10.1107/S1744309110013266  0.36
2010 Leung DW, Shabman RS, Farahbakhsh M, Prins KC, Borek DM, Wang T, Mühlberger E, Basler CF, Amarasinghe GK. Structural and functional characterization of Reston Ebola virus VP35 interferon inhibitory domain Journal of Molecular Biology. 399: 347-357. PMID 20399790 DOI: 10.1016/j.jmb.2010.04.022  0.36
2010 Yu B, Martins IR, Li P, Amarasinghe GK, Umetani J, Fernandez-Zapico ME, Billadeau DD, Machius M, Tomchick DR, Rosen MK. Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell. 140: 246-56. PMID 20141838 DOI: 10.1016/j.cell.2009.12.033  0.36
2010 Leung DW, Prins KC, Borek DM, Farahbakhsh M, Tufariello JM, Ramanan P, Nix JC, Helgeson LA, Otwinowski Z, Honzatko RB, Basler CF, Amarasinghe GK. Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35 Nature Structural and Molecular Biology. 17: 165-172. PMID 20081868 DOI: 10.1038/nsmb.1765  0.36
2010 Prins KC, Delpeut S, Leung DW, Reynard O, Volchkova VA, Reid SP, Ramanan P, Cárdenas WB, Amarasinghe GK, Volchkov VE, Basler CF. Mutations abrogating VP35 interaction with double-stranded RNA render Ebola virus avirulent in guinea pigs Journal of Virology. 84: 3004-3015. PMID 20071589 DOI: 10.1128/JVI.02459-09  0.36
2009 Basler CF, Amarasinghe GK. Evasion of interferon responses by Ebola and Marburg viruses. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 29: 511-20. PMID 19694547 DOI: 10.1089/jir.2009.0076  0.36
2009 Leung DW, Ginder ND, Nix JC, Basler CF, Honzatko RB, Amarasinghe GK. Expression, purification, crystallization and preliminary X-ray studies of the Ebola VP35 interferon inhibitory domain Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 65: 163-165. PMID 19194011 DOI: 10.1107/S1744309108044187  0.36
2009 Leung DW, Ginder ND, Fulton DB, Nix J, Basler CF, Honzatko RB, Amarasinghe GK. Structure of the Ebola VP35 interferon inhibitory domain Proceedings of the National Academy of Sciences of the United States of America. 106: 411-416. PMID 19122151 DOI: 10.1073/pnas.0807854106  0.36
2008 Li P, Martins IR, Amarasinghe GK, Rosen MK. Internal dynamics control activation and activity of the autoinhibited Vav DH domain. Nature Structural & Molecular Biology. 15: 613-8. PMID 18488041 DOI: 10.1038/nsmb.1428  0.36
2005 Amarasinghe GK, Rosen MK. Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Dbl homology domain. Biochemistry. 44: 15257-68. PMID 16285729 DOI: 10.1021/bi051126h  0.36
2003 Gelhaus SL, LaCourse WR, Hagan NA, Amarasinghe GK, Fabris D. Rapid purification of RNA secondary structures. Nucleic Acids Research. 31: e135. PMID 14576335  0.36
2001 Amarasinghe GK, Zhou J, Miskimon M, Chancellor KJ, McDonald JA, Matthews AG, Miller RR, Rouse MD, Summers MF. Stem-loop SL4 of the HIV-1 psi RNA packaging signal exhibits weak affinity for the nucleocapsid protein. structural studies and implications for genome recognition. Journal of Molecular Biology. 314: 961-70. PMID 11743714 DOI: 10.1006/jmbi.2000.5182  0.36
2000 Amarasinghe GK, De Guzman RN, Turner RB, Chancellor KJ, Wu ZR, Summers MF. NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop SL2 of the psi-RNA packaging signal. Implications for genome recognition. Journal of Molecular Biology. 301: 491-511. PMID 10926523 DOI: 10.1006/jmbi.2000.3979  0.36
2000 Amarasinghe GK, De Guzman RN, Turner RB, Summers MF. NMR structure of stem-loop SL2 of the HIV-1 psi RNA packaging signal reveals a novel A-U-A base-triple platform. Journal of Molecular Biology. 299: 145-56. PMID 10860728 DOI: 10.1006/jmbi.2000.3710  0.36
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