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Sujith V. Weerasinghe, Ph.D. - Publications

Affiliations: 
2009 Chemistry Wayne State University, Detroit, MI, United States 
Area:
Biochemistry
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18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Kwan R, Brady GF, Brzozowski M, Weerasinghe SV, Martin H, Park MJ, Brunt MJ, Menon RK, Tong X, Yin L, Stewart CL, Omary MB. Hepatocyte-Specific Deletion of Mouse Lamin A/C Leads to Male-Selective Steatohepatitis. Cellular and Molecular Gastroenterology and Hepatology. 4: 365-383. PMID 28913408 DOI: 10.1016/J.Jcmgh.2017.06.005  0.599
2016 Weerasinghe SV, Park MJ, Portney DA, Omary MB. Mouse genetic background contributes to hepatocyte susceptibility to Fas-mediated apoptosis. Molecular Biology of the Cell. PMID 27535425 DOI: 10.1091/mbc.E15-06-0423  0.59
2016 Bieliauskas AV, Weerasinghe SV, Negmeldin AT, Pflum MK. Structural Requirements of Histone Deacetylase Inhibitors: SAHA Analogs Modified on the Hydroxamic Acid. Archiv Der Pharmazie. PMID 27062198 DOI: 10.1002/Ardp.201500472  0.707
2015 Kwan R, Chen L, Looi K, Tao GZ, Weerasinghe SV, Snider NT, Conti MA, Adelstein RS, Xie Q, Omary MB. PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding. Hepatology (Baltimore, Md.). PMID 26126491 DOI: 10.1002/Hep.27965  0.633
2014 Weerasinghe SV, Jang YJ, Fontana RJ, Omary MB. Carbamoyl phosphate synthetase-1 is a rapid turnover biomarker in mouse and human acute liver injury. American Journal of Physiology. Gastrointestinal and Liver Physiology. 307: G355-64. PMID 24924744 DOI: 10.1152/ajpgi.00303.2013  0.565
2014 Weerasinghe SV, Ku NO, Altshuler PJ, Kwan R, Omary MB. Mutation of caspase-digestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity. Journal of Cell Science. 127: 1464-75. PMID 24463813 DOI: 10.1242/jcs.138479  0.58
2013 Snider NT, Griggs NW, Singla A, Moons DS, Weerasinghe SV, Lok AS, Ruan C, Burant CF, Conjeevaram HS, Omary MB. CD73 (ecto-5'-nucleotidase) hepatocyte levels differ across mouse strains and contribute to mallory-denk body formation. Hepatology (Baltimore, Md.). 58: 1790-800. PMID 23729294 DOI: 10.1002/Hep.26525  0.565
2013 Chen L, Weerasinghe S, Kwan R, Xie Q, Omary BM. Mo1772 Kinase Inhibition Normalizes Mutation-Mediated Keratin Filament Disruption and Predisposition to Apoptosis and Liver Injury Gastroenterology. 144: S-1023. DOI: 10.1016/S0016-5085(13)63799-3  0.419
2013 Weerasinghe S, Ku N, Altshuler PJ, Moons D, Omary BM. 210 Genetic Inhibition of Keratin Digestion by Caspases Promotes Hepatocyte Injury via Apoptosis and Necrosis Pathways Gastroenterology. 144: S-938-S-939. DOI: 10.1016/S0016-5085(13)63491-5  0.316
2011 Snider NT, Weerasinghe SV, Singla A, Leonard JM, Hanada S, Andrews PC, Lok AS, Omary MB. Energy determinants GAPDH and NDPK act as genetic modifiers for hepatocyte inclusion formation. The Journal of Cell Biology. 195: 217-29. PMID 22006949 DOI: 10.1083/Jcb.201102142  0.575
2011 Choi SE, Weerasinghe SV, Pflum MK. The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity. Bioorganic & Medicinal Chemistry Letters. 21: 6139-42. PMID 21889343 DOI: 10.1016/J.Bmcl.2011.08.027  0.754
2011 Weerasinghe SV, Moons DS, Altshuler PJ, Shah YM, Omary MB. Fibrinogen-γ proteolysis and solubility dynamics during apoptotic mouse liver injury: heparin prevents and treats liver damage. Hepatology (Baltimore, Md.). 53: 1323-32. PMID 21480334 DOI: 10.1016/S0016-5085(11)63941-3  0.617
2011 Snider NT, Weerasinghe SV, Iñiguez-Lluhí JA, Herrmann H, Omary MB. Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation. The Journal of Biological Chemistry. 286: 2273-84. PMID 21062750 DOI: 10.1074/Jbc.M110.171314  0.551
2010 Weerasinghe SV, Wambua M, Pflum MK. A histone deacetylase-dependent screen in yeast. Bioorganic & Medicinal Chemistry. 18: 7586-92. PMID 20863708 DOI: 10.1016/J.Bmc.2010.08.045  0.666
2010 Snider NT, Hanada S, Weerasinghe S, Andrews PC, Omary B. M1994 Molecular Factors Involved in Determining Genetic Susceptibility to Mallory-Denk Body Formation Gastroenterology. 138: S-455. DOI: 10.1016/S0016-5085(10)62103-8  0.337
2008 Weerasinghe SV, Estiu G, Wiest O, Pflum MK. Residues in the 11 A channel of histone deacetylase 1 promote catalytic activity: implications for designing isoform-selective histone deacetylase inhibitors. Journal of Medicinal Chemistry. 51: 5542-51. PMID 18729444 DOI: 10.1021/Jm800081J  0.717
2008 Singh EK, Ravula S, Pan CM, Pan PS, Vasko RC, Lapera SA, Weerasinghe SV, Pflum MK, McAlpine SR. Synthesis and biological evaluation of histone deacetylase inhibitors that are based on FR235222: a cyclic tetrapeptide scaffold. Bioorganic & Medicinal Chemistry Letters. 18: 2549-54. PMID 18381239 DOI: 10.1016/J.Bmcl.2008.03.047  0.737
2007 Bieliauskas AV, Weerasinghe SV, Pflum MK. Structural requirements of HDAC inhibitors: SAHA analogs functionalized adjacent to the hydroxamic acid. Bioorganic & Medicinal Chemistry Letters. 17: 2216-9. PMID 17307359 DOI: 10.1016/J.Bmcl.2007.01.117  0.702
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