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Tyson R. Shepherd, Ph.D. - Publications

Affiliations: 
2011 Biochemistry University of Iowa, Iowa City, IA 
Area:
Biochemistry, General Biophysics
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13 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Liu X, Golden LC, Lopez JA, Shepherd TR, Yu L, Fuentes EJ. Conformational Dynamics and Cooperativity Drive the Specificity of a Protein-Ligand Interaction. Biophysical Journal. PMID 31146922 DOI: 10.1016/J.Bpj.2019.05.008  0.777
2016 Liu X, Speckhard DC, Shepherd TR, Sun YJ, Hengel SR, Yu L, Fowler CA, Gakhar L, Fuentes EJ. Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions. Structure (London, England : 1993). 24: 2053-2066. PMID 27998539 DOI: 10.1016/J.Str.2016.08.019  0.748
2016 Fuentes EJ, Liu X, Speckhard DC, Shepherd TR, Hengel SR, Liping L, Fowler CA, Gakhar L. Conformational Dynamics and Structure Underlie the Novel Ligand Binding Specificity of a Tiam1 PDZ Domain Mutant Biophysical Journal. 110: 514a. DOI: 10.1016/J.Bpj.2015.11.2749  0.793
2014 Fuentes EJ, Liu X, Speckhard DC, Shepherd TR. Structural and Dynamic Features Underlie the Switch of Ligand Binding Specificity in a Tiam1 PDZ Domain Mutant Biophysical Journal. 106: 661a. DOI: 10.1016/J.Bpj.2013.11.3658  0.793
2013 Punekar AS, Liljeruhm J, Shepherd TR, Forster AC, Selmer M. Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ. Nucleic Acids Research. 41: 9537-48. PMID 23945937 DOI: 10.1093/Nar/Gkt719  0.438
2013 Liu Y, Collins C, Kiosses WB, Murray AM, Joshi M, Shepherd TR, Fuentes EJ, Tzima E. A novel pathway spatiotemporally activates Rac1 and redox signaling in response to fluid shear stress. The Journal of Cell Biology. 201: 863-73. PMID 23733346 DOI: 10.1083/Jcb.201207115  0.595
2013 Liu X, Shepherd TR, Murray AM, Xu Z, Fuentes EJ. The structure of the Tiam1 PDZ domain/ phospho-syndecan1 complex reveals a ligand conformation that modulates protein dynamics. Structure (London, England : 1993). 21: 342-54. PMID 23395182 DOI: 10.1016/J.Str.2013.01.004  0.774
2012 Punekar AS, Shepherd TR, Liljeruhm J, Forster AC, Selmer M. Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA. Nucleic Acids Research. 40: 10507-20. PMID 22923526 DOI: 10.1093/Nar/Gks727  0.504
2012 Fuentes EJ, Liu X, Shepherd TR, Speckhard DC, Murray AM. Specificity, Structure and Dynamics of Tiam1 PDZ Domain Ligand-Bound Complexes Biophysical Journal. 102: 411a. DOI: 10.1016/J.Bpj.2011.11.2245  0.789
2011 Shepherd TR, Fuentes EJ. Structural and thermodynamic analysis of PDZ-ligand interactions. Methods in Enzymology. 488: 81-100. PMID 21195225 DOI: 10.1016/B978-0-12-381268-1.00004-5  0.76
2011 Shepherd TR, Hard RL, Murray AM, Pei D, Fuentes EJ. Distinct ligand specificity of the Tiam1 and Tiam2 PDZ domains. Biochemistry. 50: 1296-308. PMID 21192692 DOI: 10.1021/Bi1013613  0.775
2011 Fuentes EJ, Shepherd TR. Structural and Thermodynamic Origins of Ligand Specificity in Homologous PDZ Domains from the Tiam-Family of Guanine Exchange Factors Biophysical Journal. 100: 527a. DOI: 10.1016/J.Bpj.2010.12.3081  0.785
2010 Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA, Fuentes EJ. The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion. Journal of Molecular Biology. 398: 730-46. PMID 20361982 DOI: 10.1016/J.Jmb.2010.03.047  0.778
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