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John P. Giddens - Publications

Affiliations: 
University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
glycobiology
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Giddens JP, Schiel JE. Ligand-Bound Forced Degradation as a Strategy to Generate Functionally Relevant Analytical Challenge Materials for Assessment of CQAs. Frontiers in Molecular Biosciences. 9: 789973. PMID 35480883 DOI: 10.3389/fmolb.2022.789973  0.342
2019 Wang LX, Tong X, Li C, Giddens JP, Li T. Glycoengineering of Antibodies for Modulating Functions. Annual Review of Biochemistry. PMID 30917003 DOI: 10.1146/Annurev-Biochem-062917-012911  0.678
2019 Zhang R, Cai H, Orwenyo J, Giddens J, Yang Q, LaBranche CC, Montefiori DC, Wang L. PI-6 Construction and analysis of V3 glycopeptide antigens for HIV-1 vaccine design Jaids Journal of Acquired Immune Deficiency Syndromes. 81: 78. DOI: 10.1097/01.Qai.0000558039.75095.Df  0.488
2018 Giddens JP, Lomino JV, DiLillo DJ, Ravetch JV, Wang LX. Site-selective chemoenzymatic glycoengineering of Fab and Fc glycans of a therapeutic antibody. Proceedings of the National Academy of Sciences of the United States of America. PMID 30397147 DOI: 10.1073/Pnas.1812833115  0.68
2018 Cai H, Zhang R, Orwenyo J, Giddens JP, Yang Q, LaBranche CC, Montefiori D, Wang LX. Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 N-Glycan Induces Glycan-dependent Antibodies with Promiscuous Site Recognition. Journal of Medicinal Chemistry. PMID 30384610 DOI: 10.1021/Acs.Jmedchem.8B01290  0.597
2018 Cai H, Zhang R, Orwenyo J, Giddens J, Yang Q, LaBranche CC, Montefiori DC, Wang LX. Multivalent Antigen Presentation Enhances the Immunogenicity of a Synthetic Three-Component HIV-1 V3 Glycopeptide Vaccine. Acs Central Science. 4: 582-589. PMID 29806004 DOI: 10.1021/Acscentsci.8B00060  0.597
2018 Bennett LD, Yang Q, Berquist BR, Giddens JP, Ren Z, Kommineni V, Murray RP, White EL, Holtz BR, Wang LX, Marcel S. Implementation of Glycan Remodeling to Plant-Made Therapeutic Antibodies. International Journal of Molecular Sciences. 19. PMID 29385073 DOI: 10.3390/Ijms19020421  0.59
2017 Cai H, Orwenyo J, Giddens JP, Yang Q, Zhang R, LaBranche CC, Montefiori DC, Wang LX. Synthetic Three-Component HIV-1 V3 Glycopeptide Immunogens Induce Glycan-Dependent Antibody Responses. Cell Chemical Biology. PMID 29107699 DOI: 10.1016/J.Chembiol.2017.09.005  0.595
2017 Cai H, Orwenyo J, Guenaga J, Giddens J, Toonstra C, Wyatt RT, Wang LX. Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies. Chemical Communications (Cambridge, England). PMID 28466900 DOI: 10.1039/C7Cc02059G  0.648
2017 Orwenyo J, Cai H, Giddens J, Amin MN, Toonstra C, Wang LX. Systematic Synthesis and Binding Study of HIV V3 Glycopeptides Reveal the Fine Epitopes of Several Broadly Neutralizing Antibodies. Acs Chemical Biology. PMID 28414420 DOI: 10.1021/Acschembio.7B00319  0.653
2017 Li T, DiLillo DJ, Bournazos S, Giddens JP, Ravetch JV, Wang LX. Modulating IgG effector function by Fc glycan engineering. Proceedings of the National Academy of Sciences of the United States of America. PMID 28289219 DOI: 10.1073/Pnas.1702173114  0.675
2016 Hsiao PY, Kalin J, Sun IH, Amin M, Lo YC, Chiang MJ, Giddens J, Sysa-Shah P, Gabrielson K, Wang LX, Powell J, Cole PA. An Fc-Small Molecule Conjugate for Targeted Inhibition of the Adenosine 2A Receptor. Chembiochem : a European Journal of Chemical Biology. PMID 27432157 DOI: 10.1002/Cbic.201600337  0.513
2016 Li T, Tong X, Yang Q, Giddens JP, Wang LX. Glycosynthase mutants of endoglycosidase S2 show potent transglycosylation activity and remarkably relaxed substrate specificity for antibody glycosylation remodeling. The Journal of Biological Chemistry. PMID 27288408 DOI: 10.1074/Jbc.M116.738765  0.605
2016 Giddens JP, Lomino JV, Amin MN, Wang LX. Endo-F3 glycosynthase mutants enable chemoenzymatic synthesis of core fucosylated tri-antennary complex-type glycopeptides and glycoproteins. The Journal of Biological Chemistry. PMID 26966183 DOI: 10.1074/Jbc.M116.721597  0.587
2015 Liu R, Giddens J, McClung CM, Magnelli PE, Wang LX, Guthrie EP. Evaluation of a glycoengineered monoclonal antibody via LC-MS analysis in combination with multiple enzymatic digestion. Mabs. 0. PMID 26514686 DOI: 10.1080/19420862.2015.1113361  0.614
2015 Quast I, Keller CW, Maurer MA, Giddens JP, Tackenberg B, Wang LX, Münz C, Nimmerjahn F, Dalakas MC, Lünemann JD. Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity. The Journal of Clinical Investigation. PMID 26436649 DOI: 10.1172/Jci82695  0.653
2015 Giddens JP, Wang LX. Chemoenzymatic Glyco-engineering of Monoclonal Antibodies. Methods in Molecular Biology (Clifton, N.J.). 1321: 375-87. PMID 26082235 DOI: 10.1007/978-1-4939-2760-9_25  0.683
2014 Ahmed AA, Giddens J, Pincetic A, Lomino JV, Ravetch JV, Wang LX, Bjorkman PJ. Structural characterization of anti-inflammatory immunoglobulin G Fc proteins. Journal of Molecular Biology. 426: 3166-79. PMID 25036289 DOI: 10.1016/J.Jmb.2014.07.006  0.61
2014 Trastoy B, Lomino JV, Pierce BG, Carter LG, Günther S, Giddens JP, Snyder GA, Weiss TM, Weng Z, Wang LX, Sundberg EJ. Crystal structure of Streptococcus pyogenes EndoS, an immunomodulatory endoglycosidase specific for human IgG antibodies. Proceedings of the National Academy of Sciences of the United States of America. 111: 6714-9. PMID 24753590 DOI: 10.1073/Pnas.1322908111  0.647
2014 Smith EL, Giddens JP, Iavarone AT, Godula K, Wang LX, Bertozzi CR. Chemoenzymatic Fc glycosylation via engineered aldehyde tags. Bioconjugate Chemistry. 25: 788-95. PMID 24702330 DOI: 10.1021/Bc500061S  0.571
2014 Chiang MJ, Holbert MA, Kalin JH, Ahn YH, Giddens J, Amin MN, Taylor MS, Collins SL, Chan-Li Y, Waickman A, Hsiao PY, Bolduc D, Leahy DJ, Horton MR, Wang LX, et al. An Fc domain protein-small molecule conjugate as an enhanced immunomodulator. Journal of the American Chemical Society. 136: 3370-3. PMID 24533830 DOI: 10.1021/Ja5006674  0.46
2012 Huang W, Giddens J, Fan SQ, Toonstra C, Wang LX. Chemoenzymatic glycoengineering of intact IgG antibodies for gain of functions. Journal of the American Chemical Society. 134: 12308-18. PMID 22747414 DOI: 10.1021/Ja3051266  0.686
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