Daniel J. Leahy - Publications

Affiliations: 
Biophysics and Biophysical Chemistry Johns Hopkins University, Baltimore, MD 
Area:
Molecular studies of signal transduction
Website:
http://www.hopkinsmedicine.org/pharmacology_molecular_sciences/faculty/bios/leahy.html

80 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Sun H, Luo L, Lal B, Ma X, Chen L, Hann CL, Fulton AM, Leahy DJ, Laterra J, Li M. A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis. Nature Communications. 7: 10339. PMID 26842342 DOI: 10.1038/Ncomms10339  0.333
2015 Kavran JM, Leahy DJ. Immunoaffinity Purification of Proteins. Methods in Enzymology. 559: 27-36. PMID 26096501 DOI: 10.1016/Bs.Mie.2014.11.006  0.326
2015 Li W, Koutmou KS, Leahy DJ, Li M. Systemic RNA Interference Deficiency-1 (SID-1) extracellular domain selectively binds long double-stranded RNA and is required for RNA transport by SID-1. The Journal of Biological Chemistry. PMID 26067272 DOI: 10.1074/Jbc.M115.658864  0.307
2015 Zhang W, Wu J, Ward MD, Yang S, Chuang YA, Xiao M, Li R, Leahy DJ, Worley PF. Structural basis of arc binding to synaptic proteins: implications for cognitive disease. Neuron. 86: 490-500. PMID 25864631 DOI: 10.1016/J.Neuron.2015.03.030  0.361
2015 McCabe JM, Leahy DJ. Smoothened goes molecular: new pieces in the hedgehog signaling puzzle. The Journal of Biological Chemistry. 290: 3500-7. PMID 25519909 DOI: 10.1074/Jbc.R114.617936  0.373
2015 Ward MD, Leahy DJ. Kinase activator-receiver preference in ErbB heterodimers is determined by intracellular regions and is not coupled to extracellular asymmetry. The Journal of Biological Chemistry. 290: 1570-9. PMID 25468910 DOI: 10.1074/Jbc.M114.612085  0.367
2015 Sun H, Luo L, Lal B, Ma X, Chen L, Fulton A, Leahy D, Laterra J, Li M. ATPS-82PROBING THE TUMORIGENIC PROPERTIES OF TWO PORE POTASSIUM CHANNELS USING INHIBITORY KCNK9 mAbs Neuro-Oncology. 17: v36.3-v36. DOI: 10.1093/Neuonc/Nov204.82  0.318
2015 Raines LL, Leahy DJ. Using Biochemical and Structural Approaches to Study ErbB2-Containing Heterodimers Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.2044  0.445
2015 Byrne P, Hristova K, Leahy D. Mechanisms of Autoinhibition and Dimerization of the EGF Receptor Family Biophysical Journal. 108: 351a. DOI: 10.1016/J.Bpj.2014.11.1922  0.424
2015 Salotto M, Singh DR, King C, Byrne P, Leahy D, Hristova K. Comparison of EGFR Dimer Stabilities in the Presence and Absence of the Ligand EGF Biophysical Journal. 108: 258a. DOI: 10.1016/J.Bpj.2014.11.1429  0.349
2014 Cleveland TE, McCabe JM, Leahy DJ. Detergent-solubilized Patched purified from Sf9 cells fails to interact strongly with cognate Hedgehog or Ihog homologs. Protein Expression and Purification. 104: 92-102. PMID 25261717 DOI: 10.1016/J.Pep.2014.09.012  0.442
2014 Kavran JM, McCabe JM, Byrne PO, Connacher MK, Wang Z, Ramek A, Sarabipour S, Shan Y, Shaw DE, Hristova K, Cole PA, Leahy DJ. How IGF-1 activates its receptor. Elife. 3. PMID 25255214 DOI: 10.7554/Elife.03772  0.355
2014 Wang Y, Kavran JM, Chen Z, Karukurichi KR, Leahy DJ, Cole PA. Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation. The Journal of Biological Chemistry. 289: 31361-72. PMID 25248746 DOI: 10.1074/Jbc.M114.597153  0.362
2014 King C, Sarabipour S, Byrne P, Leahy DJ, Hristova K. The FRET signatures of noninteracting proteins in membranes: simulations and experiments. Biophysical Journal. 106: 1309-17. PMID 24655506 DOI: 10.1016/J.Bpj.2014.01.039  0.315
2014 Chiang MJ, Holbert MA, Kalin JH, Ahn YH, Giddens J, Amin MN, Taylor MS, Collins SL, Chan-Li Y, Waickman A, Hsiao PY, Bolduc D, Leahy DJ, Horton MR, Wang LX, et al. An Fc domain protein-small molecule conjugate as an enhanced immunomodulator. Journal of the American Chemical Society. 136: 3370-3. PMID 24533830 DOI: 10.1021/Ja5006674  0.349
2014 Kavran JM, Leahy DJ. Lysis of mammalian and Sf9 cells. Methods in Enzymology. 536: 47-52. PMID 24423265 DOI: 10.1016/B978-0-12-420070-8.00004-0  0.3
2014 Bagchi A, Bessman NJ, Wu NZ, Raines L, Kan Z, Hu W, Englander SW, Leahy DJ, Lemmon MA, Ferguson KM. Allosteric Regulation of the Epidermal Growth Factor Receptor Biophysical Journal. 106: 105a. DOI: 10.1016/J.Bpj.2013.11.650  0.345
2014 King CR, Sarabipour S, Byrne P, Leahy D, Hristova K. The FRET Signatures of Non-Interacting Proteins in Cellular Membranes Biophysical Journal. 106: 719a. DOI: 10.1016/J.Bpj.2013.11.3973  0.314
2013 Kim MS, Leahy D. Enzymatic deglycosylation of glycoproteins Methods in Enzymology. 533: 259-263. PMID 24182931 DOI: 10.1016/B978-0-12-420067-8.00019-2  0.36
2013 Longo PA, Kavran JM, Kim MS, Leahy DJ. Transient mammalian cell transfection with polyethylenimine (PEI). Methods in Enzymology. 529: 227-40. PMID 24011049 DOI: 10.1016/B978-0-12-418687-3.00018-5  0.305
2013 Wang Z, Raines LL, Hooy RM, Roberson H, Leahy DJ, Cole PA. Tyrosine phosphorylation of mig6 reduces its inhibition of the epidermal growth factor receptor. Acs Chemical Biology. 8: 2372-6. PMID 24004111 DOI: 10.1021/Cb4005707  0.304
2013 Leahy DJ. Piecing together the extracellular puzzle. Cell. 154: 23-5. PMID 23827672 DOI: 10.1016/J.Cell.2013.06.014  0.319
2013 Leahy DJ. Magic bullets from llamas. Structure (London, England : 1993). 21: 1072-3. PMID 23823325 DOI: 10.1016/J.Str.2013.06.008  0.356
2012 Hollmén M, Liu P, Kurppa K, Wildiers H, Reinvall I, Vandorpe T, Smeets A, Deraedt K, Vahlberg T, Joensuu H, Leahy DJ, Schöffski P, Elenius K. Proteolytic processing of ErbB4 in breast cancer. Plos One. 7: e39413. PMID 22761786 DOI: 10.1371/Journal.Pone.0039413  0.306
2012 Lee CH, Kim MS, Chung BM, Leahy DJ, Coulombe PA. Structural basis for heteromeric assembly and perinuclear organization of keratin filaments. Nature Structural & Molecular Biology. 19: 707-15. PMID 22705788 DOI: 10.1038/Nsmb.2330  0.318
2012 Liu P, Cleveland TE, Bouyain S, Byrne PO, Longo PA, Leahy DJ. A single ligand is sufficient to activate EGFR dimers. Proceedings of the National Academy of Sciences of the United States of America. 109: 10861-6. PMID 22699492 DOI: 10.1073/Pnas.1201114109  0.37
2012 Liu P, Bouyain S, Eigenbrot C, Leahy DJ. The ErbB4 extracellular region retains a tethered-like conformation in the absence of the tether. Protein Science : a Publication of the Protein Society. 21: 152-5. PMID 22012915 DOI: 10.1002/Pro.753  0.441
2011 Wang Z, Longo PA, Tarrant MK, Kim K, Head S, Leahy DJ, Cole PA. Mechanistic insights into the activation of oncogenic forms of EGF receptor. Nature Structural & Molecular Biology. 18: 1388-93. PMID 22101934 DOI: 10.1038/Nsmb.2168  0.333
2011 Kim MS, Saunders AM, Hamaoka BY, Beachy PA, Leahy DJ. Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling. Proceedings of the National Academy of Sciences of the United States of America. 108: 13112-7. PMID 21828006 DOI: 10.1073/Pnas.1109877108  0.754
2011 Perilla JR, Leahy D, Woolf TB. Dynamic Importance Sampling Calculations on ECD Epitelial Growth Factor Receptor Conformational Changes Biophysical Journal. 100: 256a. DOI: 10.1016/J.Bpj.2010.12.1613  0.38
2010 Beachy PA, Hymowitz SG, Lazarus RA, Leahy DJ, Siebold C. Interactions between Hedgehog proteins and their binding partners come into view. Genes & Development. 24: 2001-12. PMID 20844013 DOI: 10.1101/Gad.1951710  0.4
2010 Leahy DJ. The ins and outs of EGFR asymmetry. Cell. 142: 513-5. PMID 20723751 DOI: 10.1016/J.Cell.2010.08.003  0.335
2010 Kavran JM, Ward MD, Oladosu OO, Mulepati S, Leahy DJ. All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. The Journal of Biological Chemistry. 285: 24584-90. PMID 20519495 DOI: 10.1074/Jbc.M110.131680  0.464
2010 Merte J, Wang Q, Vander Kooi CW, Sarsfield S, Leahy DJ, Kolodkin AL, Ginty DD. A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 5767-75. PMID 20410128 DOI: 10.1523/Jneurosci.5061-09.2010  0.364
2010 Williams EH, Pappano WN, Saunders AM, Kim MS, Leahy DJ, Beachy PA. Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Proceedings of the National Academy of Sciences of the United States of America. 107: 5869-74. PMID 20231458 DOI: 10.1073/Pnas.1001777107  0.384
2009 Qiu C, Tarrant MK, Boronina T, Longo PA, Kavran JM, Cole RN, Cole PA, Leahy DJ. In vitro enzymatic characterization of near full length EGFR in activated and inhibited states. Biochemistry. 48: 6624-32. PMID 19518076 DOI: 10.1021/Bi900755N  0.328
2008 McLellan JS, Zheng X, Hauk G, Ghirlando R, Beachy PA, Leahy DJ. The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature. 455: 979-83. PMID 18794898 DOI: 10.1038/Nature07358  0.639
2008 Leahy DJ. A molecular view of anti-ErbB monoclonal antibody therapy. Cancer Cell. 13: 291-3. PMID 18394550 DOI: 10.1016/J.Ccr.2008.03.010  0.304
2008 Qiu C, Tarrant MK, Choi SH, Sathyamurthy A, Bose R, Banjade S, Pal A, Bornmann WG, Lemmon MA, Cole PA, Leahy DJ. Mechanism of activation and inhibition of the HER4/ErbB4 kinase. Structure (London, England : 1993). 16: 460-7. PMID 18334220 DOI: 10.1016/J.Str.2007.12.016  0.358
2008 Huang GN, Huso DL, Bouyain S, Tu J, McCorkell KA, May MJ, Zhu Y, Lutz M, Collins S, Dehoff M, Kang S, Whartenby K, Powell J, Leahy D, Worley PF. NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science (New York, N.Y.). 319: 476-81. PMID 18218901 DOI: 10.1126/Science.1151227  0.337
2008 Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ. Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site. The Journal of Biological Chemistry. 283: 2734-40. PMID 18045866 DOI: 10.1074/Jbc.M703523200  0.447
2007 Leahy DJ. A monkey wrench in the kinase machine. Nature Structural & Molecular Biology. 14: 1120-1. PMID 18059449 DOI: 10.1038/Nsmb1207-1120  0.351
2007 Vander Kooi CW, Jusino MA, Perman B, Neau DB, Bellamy HD, Leahy DJ. Structural basis for ligand and heparin binding to neuropilin B domains. Proceedings of the National Academy of Sciences of the United States of America. 104: 6152-7. PMID 17405859 DOI: 10.1073/Pnas.0700043104  0.428
2007 Bouyain S, Leahy DJ. Structure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3. Protein Science : a Publication of the Protein Society. 16: 654-61. PMID 17384230 DOI: 10.1110/Ps.062700307  0.475
2007 Zhang F, McLellan JS, Ayala AM, Leahy DJ, Linhardt RJ. Kinetic and structural studies on interactions between heparin or heparan sulfate and proteins of the hedgehog signaling pathway. Biochemistry. 46: 3933-41. PMID 17348690 DOI: 10.1021/Bi6025424  0.609
2007 Smallwood PM, Williams J, Xu Q, Leahy DJ, Nathans J. Mutational analysis of Norrin-Frizzled4 recognition. The Journal of Biological Chemistry. 282: 4057-68. PMID 17158104 DOI: 10.1074/Jbc.M609618200  0.463
2006 McLellan JS, Yao S, Zheng X, Geisbrecht BV, Ghirlando R, Beachy PA, Leahy DJ. Structure of a heparin-dependent complex of Hedgehog and Ihog. Proceedings of the National Academy of Sciences of the United States of America. 103: 17208-13. PMID 17077139 DOI: 10.1073/Pnas.0606738103  0.627
2005 Zweifel ME, Leahy DJ, Barrick D. Structure and Notch receptor binding of the tandem WWE domain of Deltex. Structure (London, England : 1993). 13: 1599-611. PMID 16271883 DOI: 10.1016/J.Str.2005.07.015  0.476
2005 Bouyain S, Longo PA, Li S, Ferguson KM, Leahy DJ. The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand. Proceedings of the National Academy of Sciences of the United States of America. 102: 15024-9. PMID 16203964 DOI: 10.1073/Pnas.0507591102  0.384
2005 Geisbrecht BV, Hamaoka BY, Perman B, Zemla A, Leahy DJ. The crystal structures of EAP domains from Staphylococcus aureus reveal an unexpected homology to bacterial superantigens. The Journal of Biological Chemistry. 280: 17243-50. PMID 15691839 DOI: 10.1074/Jbc.M412311200  0.755
2004 Leahy DJ. Structure and function of the epidermal growth factor (EGF/ErbB) family of receptors. Advances in Protein Chemistry. 68: 1-27. PMID 15500857 DOI: 10.1016/S0065-3233(04)68001-6  0.379
2004 Hamaoka BY, Dann CE, Geisbrecht BV, Leahy DJ. Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A. Proceedings of the National Academy of Sciences of the United States of America. 101: 11673-8. PMID 15289613 DOI: 10.1073/Pnas.0402559101  0.724
2004 Franklin MC, Carey KD, Vajdos FF, Leahy DJ, de Vos AM, Sliwkowski MX. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell. 5: 317-28. PMID 15093539 DOI: 10.1016/S1535-6108(04)00083-2  0.471
2003 Zweifel ME, Leahy DJ, Hughson FM, Barrick D. Structure and stability of the ankyrin domain of the Drosophila Notch receptor. Protein Science : a Publication of the Protein Society. 12: 2622-32. PMID 14573873 DOI: 10.1110/Ps.03279003  0.463
2003 Burgess AW, Cho HS, Eigenbrot C, Ferguson KM, Garrett TP, Leahy DJ, Lemmon MA, Sliwkowski MX, Ward CW, Yokoyama S. An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors. Molecular Cell. 12: 541-52. PMID 14527402 DOI: 10.1016/S1097-2765(03)00350-2  0.359
2003 Geisbrecht BV, Dowd KA, Barfield RW, Longo PA, Leahy DJ. Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin. The Journal of Biological Chemistry. 278: 32561-8. PMID 12810718 DOI: 10.1074/Jbc.M302943200  0.389
2003 Ferguson KM, Berger MB, Mendrola JM, Cho HS, Leahy DJ, Lemmon MA. EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization. Molecular Cell. 11: 507-17. PMID 12620237 DOI: 10.1016/S1097-2765(03)00047-9  0.411
2003 Cho HS, Mason K, Ramyar KX, Stanley AM, Gabelli SB, Denney DW, Leahy DJ. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature. 421: 756-60. PMID 12610629 DOI: 10.1038/Nature01392  0.377
2002 Leahy DJ. New light on the integrin switch. Structure (London, England : 1993). 10: 1152-4. PMID 12220485 DOI: 10.1016/S0969-2126(02)00834-1  0.373
2002 Cho HS, Leahy DJ. Structure of the extracellular region of HER3 reveals an interdomain tether. Science (New York, N.Y.). 297: 1330-3. PMID 12154198 DOI: 10.1126/Science.1074611  0.46
2002 Gu C, Limberg BJ, Whitaker GB, Perman B, Leahy DJ, Rosenbaum JS, Ginty DD, Kolodkin AL. Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165. The Journal of Biological Chemistry. 277: 18069-76. PMID 11886873 DOI: 10.1074/Jbc.M201681200  0.424
2001 Ooi SL, Dann C, Nam K, Leahy DJ, Damha MJ, Boeke JD. RNA lariat debranching enzyme. Methods in Enzymology. 342: 233-48. PMID 11586896 DOI: 10.1016/S0076-6879(01)42548-1  0.634
2001 Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ. Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature. 412: 86-90. PMID 11452312 DOI: 10.1038/35083601  0.733
2000 Leahy DJ, Dann CE, Longo P, Perman B, Ramyar KX. A mammalian expression vector for expression and purification of secreted proteins for structural studies. Protein Expression and Purification. 20: 500-6. PMID 11087690 DOI: 10.1006/Prep.2000.1331  0.686
2000 Beneken J, Tu JC, Xiao B, Nuriya M, Yuan JP, Worley PF, Leahy DJ. Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron. 26: 143-54. PMID 10798399 DOI: 10.1016/S0896-6273(00)81145-9  0.71
1999 Fuse N, Maiti T, Wang B, Porter JA, Hall TM, Leahy DJ, Beachy PA. Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proceedings of the National Academy of Sciences of the United States of America. 96: 10992-9. PMID 10500113 DOI: 10.1073/Pnas.96.20.10992  0.437
1997 Beachy PA, Cooper MK, Young KE, von Kessler DP, Park WJ, Hall TM, Leahy DJ, Porter JA. Multiple roles of cholesterol in hedgehog protein biogenesis and signaling. Cold Spring Harbor Symposia On Quantitative Biology. 62: 191-204. PMID 9598352 DOI: 10.1101/Sqb.1997.062.01.025  0.318
1997 Leahy DJ. Implications of atomic-resolution structures for cell adhesion. Annual Review of Cell and Developmental Biology. 13: 363-93. PMID 9442878 DOI: 10.1146/Annurev.Cellbio.13.1.363  0.465
1997 Hall TM, Porter JA, Young KE, Koonin EV, Beachy PA, Leahy DJ. Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins. Cell. 91: 85-97. PMID 9335337 DOI: 10.1016/S0092-8674(01)80011-8  0.422
1996 Qu A, Leahy DJ. The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin. Structure (London, England : 1993). 4: 931-42. PMID 8805579 DOI: 10.1016/S0969-2126(96)00100-1  0.441
1996 Leahy DJ, Aukhil I, Erickson HP. 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region. Cell. 84: 155-64. PMID 8548820 DOI: 10.1016/S0092-8674(00)81002-8  0.45
1995 Qu A, Leahy DJ. Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin. Proceedings of the National Academy of Sciences of the United States of America. 92: 10277-81. PMID 7479767 DOI: 10.1073/Pnas.92.22.10277  0.42
1995 Hall TM, Porter JA, Beachy PA, Leahy DJ. A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog. Nature. 378: 212-6. PMID 7477329 DOI: 10.1038/378212A0  0.467
1994 Leahy DJ, Erickson HP, Aukhil I, Joshi P, Hendrickson WA. Crystallization of a fragment of human fibronectin: introduction of methionine by site-directed mutagenesis to allow phasing via selenomethionine. Proteins. 19: 48-54. PMID 8066086 DOI: 10.1002/Prot.340190107  0.323
1992 Leahy DJ, Axel R, Hendrickson WA. Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution. Cell. 68: 1145-62. PMID 1547508 DOI: 10.1016/0092-8674(92)90085-Q  0.391
1992 Leahy DJ, Hendrickson WA, Aukhil I, Erickson HP. Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein. Science (New York, N.Y.). 258: 987-91. PMID 1279805 DOI: 10.1126/Science.1279805  0.466
1991 Theriault TP, Leahy DJ, Levitt M, McConnell HM, Rule GS. Structural and kinetic studies of the Fab fragment of a monoclonal anti-spin label antibody by nuclear magnetic resonance. Journal of Molecular Biology. 221: 257-70. PMID 1920409 DOI: 10.1016/0022-2836(91)80218-J  0.672
1988 Leahy DJ, Rule GS, Whittaker MM, McConnell HM. Sequences of 12 monoclonal anti-dinitrophenyl spin-label antibodies for NMR studies. Proceedings of the National Academy of Sciences of the United States of America. 85: 3661-5. PMID 3375235 DOI: 10.1073/Pnas.85.11.3661  0.632
1988 Leahy DJ, Hynes TR, McConnell HM, Fox RO. Crystallization of an anti-2,2,6,6-tetramethyl-1-piperidinyloxy-dinitrophenyl monoclonal antibody Fab fragment with and without bound hapten. Journal of Molecular Biology. 203: 829-30. PMID 3210234 DOI: 10.1016/0022-2836(88)90215-X  0.407
1987 Anglister J, Bond MW, Frey T, Leahy D, Levitt M, McConnell HM, Rule GS, Tomasello J, Whittaker M. Contribution of tryptophan residues to the combining site of a monoclonal anti dinitrophenyl spin-label antibody. Biochemistry. 26: 6058-64. PMID 3120771 DOI: 10.1021/Bi00393A017  0.622
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