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Christopher D. Heinen - Publications

Affiliations: 
University of Connecticut, Storrs, CT, United States 
Area:
Philosophy of Science, Biochemistry, Oncology, Molecular Biology
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37/43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Pelletier D, Rath A, Sabbaghian N, Pelmus M, Hudon C, Jacob K, Witowski L, Saskin A, Heinen CD, Foulkes WD. Functional and phenotypic consequences of an unusual inversion in MSH2. Familial Cancer. PMID 37957483 DOI: 10.1007/s10689-023-00350-3  0.409
2022 Madden-Hennessey K, Gupta D, Radecki AA, Guild C, Rath A, Heinen CD. Loss of mismatch repair promotes a direct selective advantage in human stem cells. Stem Cell Reports. 17: 2661-2673. PMID 36368329 DOI: 10.1016/j.stemcr.2022.10.009  0.396
2022 Rath A, Radecki AA, Rahman K, Gilmore RB, Hudson JR, Cenci M, Tavtigian SV, Grady JP, Heinen CD. A calibrated cell-based functional assay to aid classification of MLH1 DNA mismatch repair gene variants. Human Mutation. PMID 36054288 DOI: 10.1002/humu.24462  0.437
2019 Brnich SE, Abou Tayoun AN, Couch FJ, Cutting GR, Greenblatt MS, Heinen CD, Kanavy DM, Luo X, McNulty SM, Starita LM, Tavtigian SV, Wright MW, Harrison SM, Biesecker LG, Berg JS, et al. Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework. Genome Medicine. 12: 3. PMID 31892348 DOI: 10.1186/S13073-019-0690-2  0.305
2019 Taghbalout A, Du M, Jillette N, Rosikiewicz W, Rath A, Heinen CD, Li S, Cheng AW. Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways. Nature Communications. 10: 4296. PMID 31541098 DOI: 10.1038/S41467-019-12339-7  0.445
2019 Rath A, Mishra A, Ferreira VD, Hu C, Omerza G, Kelly K, Hesse A, Reddi HV, Grady JP, Heinen CD. Functional Interrogation of Lynch Syndrome Associated MSH2 Missense Variants via CRISPR-Cas9 Gene Editing in Human Embryonic Stem Cells. Human Mutation. PMID 31237724 DOI: 10.1002/Humu.23848  0.571
2019 Gupta D, Heinen CD. The mismatch repair-dependent DNA damage response: Mechanisms and implications. Dna Repair. 78: 60-69. PMID 30959407 DOI: 10.1016/J.Dnarep.2019.03.009  0.631
2018 Gupta D, Lin B, Cowan A, Heinen CD. ATR-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damage. Proceedings of the National Academy of Sciences of the United States of America. PMID 29378956 DOI: 10.1073/Pnas.1720355115  0.628
2017 Lin B, Yang Q, Rath A, Heinen CD. Abstract 1411: Differential mismatch repair-dependent damage responses in subpopulations of cells from human intestinal organoids Cancer Research. 77: 1411-1411. DOI: 10.1158/1538-7445.Am2017-1411  0.432
2016 Klapacz J, Pottenger LH, Engelward BP, Heinen CD, Johnson GE, Clewell RA, Carmichael PL, Adeleye Y, Andersen ME. Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents. Mutation Research. Reviews in Mutation Research. 767: 77-91. PMID 27036068 DOI: 10.1016/J.Mrrev.2015.11.001  0.59
2016 Fishel R, Heinen CD. Enhanced gene targeting to evaluate Lynch syndrome alterations. Proceedings of the National Academy of Sciences of the United States of America. PMID 27035997 DOI: 10.1073/Pnas.1602650113  0.488
2016 Heinen CD. Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancer. Dna Repair. 38: 127-34. PMID 26710976 DOI: 10.1016/J.Dnarep.2015.11.025  0.461
2015 Lynch HT, Snyder CL, Shaw TG, Heinen CD, Hitchins MP. Milestones of Lynch syndrome: 1895-2015. Nature Reviews. Cancer. 15: 181-94. PMID 25673086 DOI: 10.1038/Nrc3878  0.365
2015 Klapacz J, Pottenger LH, Engelward BP, Heinen CD, Johnson GE, Clewell RA, Carmichael PL, Adeleye Y, Andersen ME. Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents Mutation Research - Reviews in Mutation Research. DOI: 10.1016/j.mrrev.2015.11.001  0.415
2014 Lin B, Gupta D, Heinen CD. Human pluripotent stem cells have a novel mismatch repair-dependent damage response. The Journal of Biological Chemistry. 289: 24314-24. PMID 25012654 DOI: 10.1074/Jbc.M114.570937  0.62
2014 Heinen CD. Translating mismatch repair mechanism into cancer care. Current Drug Targets. 15: 53-64. PMID 24387335 DOI: 10.2174/1389450114666140106100128  0.482
2014 Thompson BA, Spurdle AB, Plazzer JP, Greenblatt MS, Akagi K, Al-Mulla F, Bapat B, Bernstein I, Capellá G, den Dunnen JT, du Sart D, Fabre A, Farrell MP, Farrington SM, Frayling IM, ... ... Heinen CD, et al. Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database. Nature Genetics. 46: 107-15. PMID 24362816 DOI: 10.1038/Ng.2854  0.315
2013 Rasmussen LJ, Heinen CD, Royer-Pokora B, Drost M, Tavtigian S, Hofstra RM, de Wind N. Response to: Design of a core classification process for DNA mismatch repair variations of a priori unknown functional significance. Human Mutation. 34: 923-4. PMID 23554108 DOI: 10.1002/Humu.22310  0.519
2012 Rasmussen LJ, Heinen CD, Royer-Pokora B, Drost M, Tavtigian S, Hofstra RM, de Wind N. Pathological assessment of mismatch repair gene variants in Lynch syndrome: past, present, and future. Human Mutation. 33: 1617-25. PMID 22833534 DOI: 10.1002/Humu.22168  0.431
2012 Heinen CD, Juel Rasmussen L. Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays. Hereditary Cancer in Clinical Practice. 10: 9. PMID 22824075 DOI: 10.1186/1897-4287-10-9  0.491
2012 Cyr JL, Brown GD, Stroop J, Heinen CD. The predicted truncation from a cancer-associated variant of the MSH2 initiation codon alters activity of the MSH2-MSH6 mismatch repair complex. Molecular Carcinogenesis. 51: 647-58. PMID 21837758 DOI: 10.1002/Mc.20838  0.546
2011 Mohni KN, Mastrocola AS, Bai P, Weller SK, Heinen CD. DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication. Journal of Virology. 85: 12241-53. PMID 21957315 DOI: 10.1128/Jvi.05487-11  0.686
2011 Heinen CD, Cyr JL, Cook C, Punja N, Sakato M, Forties RA, Lopez JM, Hingorani MM, Fishel R. Human MSH2 (hMSH2) protein controls ATP processing by hMSH2-hMSH6. The Journal of Biological Chemistry. 286: 40287-95. PMID 21937421 DOI: 10.1074/Jbc.M111.297523  0.353
2011 Hollenbach JP, Resch AM, Palakodeti D, Graveley BR, Heinen CD. Loss of DNA mismatch repair imparts a selective advantage in planarian adult stem cells. Plos One. 6: e21808. PMID 21747960 DOI: 10.1371/Journal.Pone.0021808  0.752
2010 Mastrocola AS, Heinen CD. Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo. Human Mutation. 31: E1699-708. PMID 20672385 DOI: 10.1002/Humu.21333  0.714
2010 Mastrocola AS, Heinen CD. Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage. Dna Repair. 9: 120-33. PMID 20004149 DOI: 10.1016/J.Dnarep.2009.11.003  0.706
2010 Heinen CD. Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families. Mutation Research. 693: 32-45. PMID 19766128 DOI: 10.1016/J.Mrfmmm.2009.09.004  0.379
2008 Cyr JL, Heinen CD. Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding. The Journal of Biological Chemistry. 283: 31641-8. PMID 18790734 DOI: 10.1074/Jbc.M806018200  0.509
2007 Rosenberg DW, Yang S, Pleau DC, Greenspan EJ, Stevens RG, Rajan TV, Heinen CD, Levine J, Zhou Y, O'Brien MJ. Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans. Cancer Research. 67: 3551-4. PMID 17440063 DOI: 10.1158/0008-5472.Can-07-0343  0.351
2007 Greenspan EJ, Cyr JL, Pleau DC, Levine J, Rajan TV, Rosenberg DW, Heinen CD. Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer. Carcinogenesis. 28: 769-76. PMID 17088260 DOI: 10.1093/Carcin/Bgl209  0.367
2004 Shim KS, Schmutte C, Tombline G, Heinen CD, Fishel R. hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51. The Journal of Biological Chemistry. 279: 30385-94. PMID 15123651 DOI: 10.1074/Jbc.M306066200  0.47
2003 Fishel R, Acharya S, Berardini M, Bocker T, Charbonneau N, Cranston A, Gradia S, Guerrette S, Heinen CD, Mazurek A, Snowden T, Schmutte C, Shim KS, Tombline G, Wilson T. Signaling mismatch repair: the mechanics of an adenosine-nucleotide molecular switch. Cold Spring Harbor Symposia On Quantitative Biology. 65: 217-24. PMID 12760035 DOI: 10.1101/Sqb.2000.65.217  0.314
2002 Heinen CD, Schmutte C, Fishel R. DNA repair and tumorigenesis: lessons from hereditary cancer syndromes. Cancer Biology & Therapy. 1: 477-85. PMID 12496472 DOI: 10.4161/Cbt.1.5.160  0.615
2002 Heinen CD, Goss KH, Cornelius JR, Babcock GF, Knudsen ES, Kowalik T, Groden J. The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway. Gastroenterology. 123: 751-63. PMID 12198702 DOI: 10.1053/Gast.2002.35382  0.343
2002 Heinen CD, Wilson T, Mazurek A, Berardini M, Butz C, Fishel R. HNPCC mutations in hMSH2 result in reduced hMSH2-hMSH6 molecular switch functions. Cancer Cell. 1: 469-78. PMID 12124176 DOI: 10.1016/S1535-6108(02)00073-9  0.437
2002 Tombline G, Heinen CD, Shim KS, Fishel R. Biochemical characterization of the human RAD51 protein. III. Modulation of DNA binding by adenosine nucleotides. The Journal of Biological Chemistry. 277: 14434-42. PMID 11839741 DOI: 10.1074/Jbc.M109917200  0.44
1997 Heinen CD, Noffsinger AE, Belli J, Straughen J, Fischer J, Groden J, Fenoglio-Preiser CM. Regenerative lesions in ulcerative colitis are characterized by microsatellite mutation Genes Chromosomes and Cancer. 19: 170-175. PMID 9218998 DOI: 10.1002/(Sici)1098-2264(199707)19:3<170::Aid-Gcc6>3.0.Co;2-V  0.521
Low-probability matches (unlikely to be authored by this person)
2006 Shim KS, Tombline G, Heinen CD, Charbonneau N, Schmutte C, Fishel R. Magnesium influences the discrimination and release of ADP by human RAD51. Dna Repair. 5: 704-17. PMID 16624636 DOI: 10.1016/J.Dnarep.2006.03.004  0.289
2007 Stevens RG, Swede H, Heinen CD, Jablonski M, Grupka M, Ross B, Parente M, Tirnauer JS, Giardina C, Rajan TV, Rosenberg DW, Levine J. Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer. Cancer Letters. 248: 262-8. PMID 16950561 DOI: 10.1016/J.Canlet.2006.08.003  0.259
2012 Anderson JC, Swede H, Rustagi T, Protiva P, Pleau D, Brenner BM, Rajan TV, Heinen CD, Levine JB, Rosenberg DW. Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy. Cancer Causes & Control : Ccc. 23: 355-61. PMID 22187142 DOI: 10.1007/S10552-011-9884-7  0.253
2010 Anderson JC, Pleau DC, Rajan TV, Protiva P, Swede H, Brenner B, Heinen CD, Lambrecht RW, Rosenberg DW. Increased frequency of serrated aberrant crypt foci among smokers. The American Journal of Gastroenterology. 105: 1648-54. PMID 20234347 DOI: 10.1038/Ajg.2010.109  0.25
2000 Heinen CD. Respect for the opposition. Science (New York, N.Y.). 287: 2422. PMID 10766617 DOI: 10.1126/Science.287.5462.2421E  0.22
1993 Brun J, Rama D, Bouix O, Supparo I, Larue C, Calzolari C, Lagrange M, Heinen C, Micallef J, Orsetti A. Variations physiologiques de la myosinémie en relation avec l'activité musculaire Science & Sports. 8: 261-268. DOI: 10.1016/S0765-1597(05)80107-8  0.014
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