Ron A. Laskey - Publications

Affiliations: 
University of Cambridge, Hutchison/MRC Research Centre 
Area:
Nuclear transport, mammalian DNA replication
Website:
http://www.hutchison-mrc.cam.ac.uk/Research/Ron_Laskey/index.html

79 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Wickramasinghe VO, Andrews R, Ellis P, Langford C, Gurdon JB, Stewart M, Venkitaraman AR, Laskey RA. Selective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP. Nucleic Acids Research. 42: 5059-71. PMID 24510098 DOI: 10.1093/Nar/Gku095  0.521
2012 Poole E, Bain M, Teague L, Takei Y, Laskey R, Sinclair J. The Cellular Protein MCM3AP Is Required for Inhibition of Cellular DNA Synthesis by the IE86 Protein of Human Cytomegalovirus Plos One. 7. PMID 23094019 DOI: 10.1371/journal.pone.0045686  0.372
2010 Wickramasinghe VO, McMurtrie PI, Mills AD, Takei Y, Penrhyn-Lowe S, Amagase Y, Main S, Marr J, Stewart M, Laskey RA. mRNA export from mammalian cell nuclei is dependent on GANP. Current Biology : Cb. 20: 25-31. PMID 20005110 DOI: 10.1016/J.Cub.2009.10.078  0.315
2005 Laskey R. Solving mysteries of DNA replication and frog cloning Cell. 123: 760-762. PMID 16325570 DOI: 10.1016/j.cell.2005.11.008  0.365
2005 Tachibana KK, Gonzalez MA, Guarguaglini G, Nigg EA, Laskey RA. Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects Embo Reports. 6: 1052-1057. PMID 16179947 DOI: 10.1038/Sj.Embor.7400527  0.337
2005 Laskey R. The Croonian Lecture 2001 hunting the antisocial cancer cell: MCM proteins and their exploitation Philosophical Transactions of the Royal Society B: Biological Sciences. 360: 1119-1132. PMID 16147513 DOI: 10.1098/rstb.2005.1656  0.378
2005 McGeoch AT, Trakselis MA, Laskey RA, Bell SD. Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism Nature Structural and Molecular Biology. 12: 756-762. PMID 16116441 DOI: 10.1038/Nsmb974  0.667
2005 Gonzalez MA, Tachibana KEK, Laskey RA, Coleman N. Control of DNA replication and its potential clinical exploitation Nature Reviews Cancer. 5: 135-141. PMID 15660109 DOI: 10.1038/nrc1548  0.327
2003 Laskey RA, Madine MA. A rotary pumping model for helicase function of MCM proteins at a distance from replication forks Embo Reports. 4: 26-30. PMID 12524516 DOI: 10.1038/sj.embor.embor706  0.345
2002 Takei Y, Assenberg M, Tsujimoto G, Laskey R. The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3 Journal of Biological Chemistry. 277: 43121-43125. PMID 12226073 DOI: 10.1074/jbc.C200442200  0.376
2002 Pelizon C, d'Adda di Fagagna F, Farrace L, Laskey RA. Human replication protein Cdc6 is selectively cleaved by caspase 3 during apoptosis Embo Reports. 3: 780-784. PMID 12151338 DOI: 10.1093/embo-reports/kvf161  0.303
2002 Coverley D, Laman H, Laskey RA. Distinct roles for cyclins E and A during DNA replication complex assembly and activation Nature Cell Biology. 4: 523-528. PMID 12080347 DOI: 10.1038/ncb813  0.342
2001 Takei Y, Swietlik M, Tanoue A, Tsujimoto G, Kouzarides T, Laskey R. MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3 Embo Reports. 2: 119-123. PMID 11258703 DOI: 10.1093/Embo-Reports/Kve026  0.382
2000 Pelizon C, Madine MA, Romanowski P, Laskey RA. Unphosphorylatable mutants of Cdc6 disrupt its nuclear export but still support DNA replication once per cell cycle Genes and Development. 14: 2526-2533. PMID 11018019 DOI: 10.1101/gad.176300  0.356
2000 Coverley D, Pelizon C, Trewick S, Laskey RA. Chromatin-bound Cdc6 persists in S and G2 phases in human cells, while soluble Cdc6 is destroyed in a cyclin A-cdk2 dependent process Journal of Cell Science. 113: 1929-1938. PMID 10806104  0.322
2000 Madine MA, Swietlik M, Pelizon C, Romanowski P, Mills AD, Laskey RA. The roles of the MCM, ORC, and Cdc6 proteins in determining the replication competence of chromatin in quiescent cells Journal of Structural Biology. 129: 198-210. PMID 10806069 DOI: 10.1006/jsbi.2000.4218  0.405
2000 Philpott A, Krude T, Laskey RA. Nuclear chaperones. Seminars in Cell & Developmental Biology. 11: 7-14. PMID 10736259 DOI: 10.1006/Scdb.1999.0346  0.755
2000 Romanowski P, Marr J, Madine MA, Rowles A, Blow JJ, Gautier J, Laskey RA. Interaction of Xenopus Cdc2·cyclin A1 with the origin recognition complex Journal of Biological Chemistry. 275: 4239-4243. PMID 10660590 DOI: 10.1074/Jbc.275.6.4239  0.579
1998 Stoeber K, Mills AD, Kubota Y, Krude T, Romanowski P, Marheineke K, Laskey RA, Williams GH. Cdc6 protein causes premature entry into S phase in a mammalian cell-free system Embo Journal. 17: 7219-7229. PMID 9857179 DOI: 10.1093/Emboj/17.24.7219  0.691
1998 Ritzi M, Baack M, Musahl C, Romanowski P, Laskey RA, Knippers R. Human minichromosome maintenance proteins and human origin recognition complex 2 protein on chromatin Journal of Biological Chemistry. 273: 24543-24549. PMID 9733749 DOI: 10.1074/Jbc.273.38.24543  0.676
1997 Crevel G, Huikeshoven H, Cotterill S, Simon M, Wall J, Philpott A, Laskey RA, McConnell M, Fisher PA, Berrios M. Molecular and cellular characterization of CRP1, a Drosophila chromatin decondensation protein. Journal of Structural Biology. 118: 9-22. PMID 9087911 DOI: 10.1006/Jsbi.1996.3836  0.554
1997 Krude T, Jackman M, Pines J, Laskey RA. Cyclin/Cdk-dependent initiation of DNA replication in a human cell-free system Cell. 88: 109-119. PMID 9019396 DOI: 10.1016/S0092-8674(00)81863-2  0.658
1996 Laskey RA, Görlich D, Madine MA, Makkerh JP, Romanowski P. Regulatory roles of the nuclear envelope. Experimental Cell Research. 229: 204-11. PMID 8986599 DOI: 10.1006/excr.1996.0361  0.645
1996 Romanowski P, Madine MA, Rowles A, Blow JJ, Laskey RA. The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin Current Biology. 6: 1416-1425. PMID 8939603 DOI: 10.1016/S0960-9822(96)00746-4  0.673
1996 Görlich D, Kraft R, Kostka S, Vogel F, Hartmann E, Laskey RA, Mattaj IW, Izaurralde E. Importin provides a link between nuclear protein import and U snRNA export. Cell. 87: 21-32. PMID 8858145 DOI: 10.1016/S0092-8674(00)81319-7  0.565
1996 Krude T, Musahl C, Laskey RA, Knippers R. Human replication proteins hCdc21, hCdc46 and P1Mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication Journal of Cell Science. 109: 309-318. PMID 8838654  0.411
1996 Romanowski P, Madine MA, Laskey RA. XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication Proceedings of the National Academy of Sciences of the United States of America. 93: 10189-10194. PMID 8816774 DOI: 10.1073/pnas.93.19.10189  0.413
1996 Leno GH, Mills AD, Philpott A, Laskey RA. Hyperphosphorylation of nucleoplasmin facilitates Xenopus sperm decondensation at fertilization. The Journal of Biological Chemistry. 271: 7253-6. PMID 8631735 DOI: 10.1074/Jbc.271.13.7253  0.577
1996 Görlich D, Henklein P, Laskey RA, Hartmann E. A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus. The Embo Journal. 15: 1810-7. PMID 8617226  0.524
1995 Görlich D, Laskey RA. Roles of importin in nuclear protein import. Cold Spring Harbor Symposia On Quantitative Biology. 60: 695-9. PMID 8824444  0.565
1995 Madine MA, Khoo CY, Mills AD, Musahl C, Laskey RA. The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts Current Biology. 5: 1270-1279. PMID 8574584 DOI: 10.1016/S0960-9822(95)00253-3  0.407
1995 Madine MA, Khoo CY, Mills AD, Laskey RA. MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells Nature. 375: 421-424. PMID 7760938  0.419
1995 Görlich D, Vogel F, Mills AD, Hartmann E, Laskey RA. Distinct functions for the two importin subunits in nuclear protein import. Nature. 377: 246-8. PMID 7675110 DOI: 10.1038/377246a0  0.56
1995 Görlich D, Kostka S, Kraft R, Dingwall C, Laskey RA, Hartmann E, Prehn S. Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope. Current Biology : Cb. 5: 383-92. PMID 7627554 DOI: 10.1016/S0960-9822(95)00079-0  0.598
1994 Görlich D, Prehn S, Laskey RA, Hartmann E. Isolation of a protein that is essential for the first step of nuclear protein import. Cell. 79: 767-78. PMID 8001116 DOI: 10.1016/0092-8674(94)90067-1  0.591
1994 Coverley D, Laskey RA. Regulation of eukaryotic DNA replication Annual Review of Biochemistry. 63: 745-776. PMID 7979254  0.335
1993 Laskey RA, Mills AD, Philpott A, Leno GH, Dilworth SM, Dingwall C. The role of nucleoplasmin in chromatin assembly and disassembly. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 339: 263-9; discussion 26. PMID 8098530 DOI: 10.1098/Rstb.1993.0024  0.609
1992 Sleeman AM, Leno GH, Mills AD, Fairman MP, Laskey RA. Patterns of DNA replication in Drosophila polytene nuclei replicating in Xenopus egg and oocyte extracts Journal of Cell Science. 101: 509-515. PMID 1522141  0.326
1991 Philpott A, Leno GH, Laskey RA. Sperm decondensation in Xenopus egg cytoplasm is mediated by nucleoplasmin. Cell. 65: 569-78. PMID 2032284 DOI: 10.1016/0092-8674(91)90089-H  0.566
1991 Leno GH, Laskey RA. The nuclear membrane determines the timing of DNA replication in Xenopus egg extracts Journal of Cell Biology. 112: 557-566. PMID 1993731  0.325
1991 Cox LS, Laskey RA. DNA replication occurs at discrete sites in pseudonuclei assembled from purified DNA in vitro Cell. 66: 271-275. PMID 1830242 DOI: 10.1016/0092-8674(91)90617-8  0.345
1991 Laskey RA, Cox LS, Leno GH, Philpott A, Mills AD, Sleeman AM. Control of DNA replication in reconstituted nuclei. Cold Spring Harbor Symposia On Quantitative Biology. 56: 347-52. PMID 1819495 DOI: 10.1101/Sqb.1991.056.01.041  0.58
1991 Leno GH, Laskey RA. Chapter 29 DNA Replication in Cell-Free Extracts from Xenopus laevis Methods in Cell Biology. 36: 561-574,574a,574b,57. PMID 1811152 DOI: 10.1016/S0091-679X(08)60297-6  0.316
1990 Laskey RA, Leno GH. Assembly of the cell nucleus Trends in Genetics. 6: 406-409. PMID 2087783 DOI: 10.1016/0168-9525(90)90301-L  0.308
1989 Laskey RA, Fairman MP, Blow JJ. S phase of the cell cycle Science. 246: 609-614. PMID 2683076 DOI: 10.1126/Science.2683076  0.624
1989 Blow JJ, Sheehan MA, Watson JV, Laskey RA. Nuclear structure and the control of DNA replication in the Xenopus embryo Journal of Cell Science. 94: 183-195. PMID 2635705 DOI: 10.1242/Jcs.1989.Supplement_12.16  0.651
1989 Mills AD, Blow JJ, White JG, Amos WB, Wilcock D, Laskey RA. Replication occurs at discrete foci spaced throughout nuclei replicating in vitro Journal of Cell Science. 94: 471-477. PMID 2632579  0.597
1988 Blow JJ, Laskey RA. A role for the nuclear envelope in controlling DNA replication within the cell cycle Nature. 332: 546-548. PMID 3357511 DOI: 10.1038/332546A0  0.64
1988 Sheehan MA, Mills AD, Sleeman AM, Laskey RA, Blow JJ. Steps in the assembly of replication-competent nuclei in a cell-free system from Xenopus eggs Journal of Cell Biology. 106: 1-12. PMID 3339085 DOI: 10.1083/Jcb.106.1.1  0.607
1988 Richardson WD, Mills AD, Dilworth SM, Laskey RA, Dingwall C. Nuclear protein migration involves two steps: rapid binding at the nuclear envelope followed by slower translocation through nuclear pores. Cell. 52: 655-64. PMID 3125984 DOI: 10.1016/0092-8674(88)90403-5  0.327
1987 Blow JJ, Dilworth SM, Dingwall C, Mills AD, Laskey RA. Chromosome replication in cell-free systems from Xenopus eggs. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 317: 483-494. PMID 2894683 DOI: 10.1098/Rstb.1987.0075  0.663
1986 Blow JJ, Laskey RA. Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs Cell. 47: 577-587. PMID 3779837 DOI: 10.1016/0092-8674(86)90622-7  0.625
1985 Laskey RA, Kearsey SE, Mechali M, Dingwall C, Mills AD, Dilworth SM, Kleinschmidt J. Chromosome replication in early Xenopus embryos. Cold Spring Harbor Symposia On Quantitative Biology. 50: 657-63. PMID 3868500  0.397
1985 Laskey RA. Chromosome replication in early development of Xenopus laevis. Journal of Embryology and Experimental Morphology. 89: 285-96. PMID 3831215  0.339
1983 Laskey RA, Harland RM, Méchali M. Induction of chromosome replication during maturation of amphibian oocytes. Ciba Foundation Symposium. 98: 25-43. PMID 6557009  0.586
1983 Méchali M, Méchali F, Laskey RA. Tumor promoter TPA increases initiation of replication on DNA injected into xenopus eggs. Cell. 35: 63-9. PMID 6226366 DOI: 10.1016/0092-8674(83)90208-8  0.358
1983 Laskey RA, Mechali M. Accelerated chromatin replication in embryonic cells Cell Biology International Reports. 7: 547-548. DOI: 10.1016/0309-1651(83)90171-6  0.308
1982 Gurdon JB, Dingwall C, Laskey RA, Korn LJ. Developmental inactivity of 5S RNA genes persists when chromosomes are cut between genes. Nature. 299: 652-3. PMID 6889684 DOI: 10.1038/299652A0  0.707
1982 Laskey RA, Harland RM. Replication origins in the Xenopus egg. Cell. 31: 503. PMID 6297769  0.499
1981 Laskey RA, Harland RM. Replication origins in the eucaryotic chromosome. Cell. 24: 283-4. PMID 6263494  0.433
1980 Mills AD, Laskey RA, Black P, De Robertis EM. An acidic protein which assembles nucleosomes in vitro is the most abundant protein in Xenopus oocyte nuclei. Journal of Molecular Biology. 139: 561-8. PMID 7441745 DOI: 10.1016/0022-2836(80)90148-5  0.554
1980 Earnshaw WC, Honda BM, Laskey RA, Thomas JO. Assembly of nucleosomes: the reaction involving X. laevis nucleoplasmin. Cell. 21: 373-83. PMID 7407918 DOI: 10.1016/0092-8674(80)90474-2  0.562
1980 Harland RM, Laskey RA. Regulated replication of DNA microinjected into eggs of Xenopus laevis. Cell. 21: 761-71. PMID 6254667  0.571
1980 Laskey RA, Earnshaw WC. Nucleosome assembly. Nature. 286: 763-7. PMID 6250082 DOI: 10.1038/286763a0  0.553
1979 Gurdon JB, Laskey RA, De Robertis EM, Partington GA. Reprogramming of transplanted nuclei in amphibia. International Review of Cytology. Supplement. 161-78. PMID 385535  0.564
1978 Laskey RA, Honda BM, Mills AD, Finch JT. Nucleosomes are assembled by an acidic protein which binds histones and transfers them to DNA Nature. 275: 416-420. PMID 692721 DOI: 10.1038/275416a0  0.373
1978 Laskey RA, Honda BM, Mills AD, Morris NR, Wyllie AH, Mertz JE, De Roberts EM, Gurdon JB. Chromatin assembly and transcription in eggs and oocytes of Xenopus laevis. Cold Spring Harbor Symposia On Quantitative Biology. 42: 171-8. PMID 209936 DOI: 10.1101/Sqb.1978.042.01.019  0.682
1978 Wyllie AH, Laskey RA, Finch J, Gurdon JB. Selective DNA conservation and chromatin assembly after injection of SV40 DNA into Xenopus oocytes. Developmental Biology. 64: 178-88. PMID 207607 DOI: 10.1016/0012-1606(78)90069-6  0.586
1977 Laskey RA, Mills AD, Gurdon JB, Partington GA. Protein synthesis in oocytes of Xenopus laevis is not regulated by the supply of messenger RNA. Cell. 11: 345-51. PMID 560911 DOI: 10.1016/0092-8674(77)90051-4  0.48
1977 de Robertis EM, Gurdon JB, Partington GA, Mertz JE, Laskey RA. Injected amphibian oocytes: a living test tube for the study of eukaryotic gene transcription? Biochemical Society Symposium. 181-91. PMID 339919  0.743
1977 Laskey RA, Mills AD, Morris NR. Assembly of SV40 chromatin in a cell-free system from Xenopus eggs Cell. 10: 237-243. PMID 189936 DOI: 10.1016/0092-8674(77)90217-3  0.393
1977 De Robertis EM, Laskey RA, Gurdon JB. Injected living cells as a biochemical test tube Trends in Biochemical Sciences. 2: N250-N251,N253. DOI: 10.1016/0968-0004(77)90206-7  0.418
1975 Gurdon JB, Laskey RA, Reeves OR. The developmental capacity of nuclei transplanted from keratinized skin cells of adult frogs. Journal of Embryology and Experimental Morphology. 34: 93-112. PMID 1102625  0.487
1974 Laskey RA, Gurdon JB. The translation of viral RNAs in frog oocytes. Hã¤Matologie Und Bluttransfusion. 14: 272-4. PMID 4615046  0.458
1973 Laskey RA, Gurdon JB. Induction of polyoma DNA synthesis by injection into frog-egg cytoplasm. European Journal of Biochemistry / Febs. 37: 467-71. PMID 4359989 DOI: 10.1111/J.1432-1033.1973.Tb03007.X  0.539
1972 Laskey RA, Gurdon JB, Crawford LV. Translation of encephalomyocarditis viral RNA in oocytes of Xenopus laevis. Proceedings of the National Academy of Sciences of the United States of America. 69: 3665-9. PMID 4345506 DOI: 10.1073/Pnas.69.12.3665  0.486
1970 Gurdon JB, Laskey RA. The transplantation of nuclei from single cultured cells into enucleate frogs' eggs. Journal of Embryology and Experimental Morphology. 24: 227-48. PMID 5531072  0.455
1970 Laskey RA, Gurdon JB. Genetic content of adult somatic cells tested by nuclear transplantation from cultured cells. Nature. 228: 1332-4. PMID 5530658 DOI: 10.1038/2281332A0  0.471
1970 Gurdon JB, Laskey RA. Methods of transplanting nuclei from single cultured cells to unfertilized frogs' eggs. Journal of Embryology and Experimental Morphology. 24: 249-55. PMID 4923666  0.451
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