Year |
Citation |
Score |
2022 |
Parkinson LM, Gillen SL, Woods LM, Chaytor L, Marcos D, Ali FR, Carroll JS, Philpott A. The proneural transcription factor ASCL1 regulates cell proliferation and primes for differentiation in neuroblastoma. Frontiers in Cell and Developmental Biology. 10: 942579. PMID 36263020 DOI: 10.3389/fcell.2022.942579 |
0.368 |
|
2022 |
Azzarelli R, McNally A, Dell'Amico C, Onorati M, Simons B, Philpott A. ASCL1 phosphorylation and ID2 upregulation are roadblocks to glioblastoma stem cell differentiation. Scientific Reports. 12: 2341. PMID 35149717 DOI: 10.1038/s41598-022-06248-x |
0.308 |
|
2021 |
Philpott A. The Use of for Cell Biology Applications. Cold Spring Harbor Protocols. PMID 33782096 DOI: 10.1101/pdb.top105528 |
0.331 |
|
2020 |
Ali FR, Marcos D, Chernukhin I, Woods LM, Parkinson LM, Wylie LA, Papkovskaia TD, Davies JD, Carroll JS, Philpott A. Dephosphorylation of the proneural transcription factor ASCL1 re-engages a latent post-mitotic differentiation programme in neuroblastoma. Molecular Cancer Research : McR. PMID 33046535 DOI: 10.1158/1541-7786.MCR-20-0693 |
0.331 |
|
2019 |
Han S, Fink J, Jörg DJ, Lee E, Yum MK, Chatzeli L, Merker SR, Josserand M, Trendafilova T, Andersson-Rolf A, Dabrowska C, Kim H, Naumann R, Lee JH, Sasaki N, ... ... Philpott A, et al. Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells. Cell Stem Cell. PMID 31422913 DOI: 10.1016/J.Stem.2019.07.008 |
0.328 |
|
2019 |
Hardwick LJA, Philpott A. Analysis of Chromatin Binding of Ectopically Expressed Proteins in Early Embryos. Cold Spring Harbor Protocols. PMID 31138717 DOI: 10.1101/Pdb.Prot105577 |
0.462 |
|
2019 |
Hardwick LJA, Philpott A. Analysis of Phosphorylation Status of Ectopically Expressed Proteins in Early Embryos. Cold Spring Harbor Protocols. PMID 31138716 DOI: 10.1101/Pdb.Prot105569 |
0.442 |
|
2019 |
Hardwick LJA, Davies JD, Philpott A. Multi-site phosphorylation controls the neurogenic and myogenic activity of E47. Biochemical and Biophysical Research Communications. 511: 111-116. PMID 30773262 DOI: 10.1016/J.Bbrc.2019.02.045 |
0.418 |
|
2019 |
Hardwick LJA, Philpott A. N-terminal phosphorylation of xHes1 controls inhibition of primary neurogenesis in Xenopus. Biochemical and Biophysical Research Communications. 509: 557-563. PMID 30600182 DOI: 10.1016/J.Bbrc.2018.12.135 |
0.519 |
|
2018 |
Hardwick LJA, Philpott A. Models of Cancer: Expanding the Oncologist's Toolbox. Frontiers in Physiology. 9: 1660. PMID 30538639 DOI: 10.3389/Fphys.2018.01660 |
0.313 |
|
2018 |
Hardwick LJA, Philpott A. Interaction between opposing modes of phospho-regulation of the proneural proteins Ascl1 and Ngn2. Wellcome Open Research. 3: 129. PMID 30430141 DOI: 10.12688/wellcomeopenres.14848.1 |
0.389 |
|
2018 |
Hardwick LJA, Philpott A. The N terminus of Ascl1 underlies differing proneural activity of mouse and Ascl1 proteins. Wellcome Open Research. 3: 125. PMID 30363793 DOI: 10.12688/wellcomeopenres.14842.1 |
0.386 |
|
2018 |
Azzarelli R, Rulands S, Nestorowa S, Davies J, Campinoti S, Gillotin S, Bonfanti P, Göttgens B, Huch M, Simons B, Philpott A. Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells. Scientific Reports. 8: 15374. PMID 30337647 DOI: 10.1038/S41598-018-33838-5 |
0.332 |
|
2018 |
Hardwick LJA, Azzarelli R, Philpott A. Cell cycle-dependent phosphorylation and regulation of cellular differentiation. Biochemical Society Transactions. PMID 30242121 DOI: 10.1042/Bst20180276 |
0.455 |
|
2018 |
Tomic G, Morrissey E, Kozar S, Ben-Moshe S, Hoyle A, Azzarelli R, Kemp R, Chilamakuri CSR, Itzkovitz S, Philpott A, Winton DJ. Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration. Cell Stem Cell. PMID 30100168 DOI: 10.1016/J.Stem.2018.07.002 |
0.376 |
|
2018 |
Sznurkowska MK, Hannezo E, Azzarelli R, Rulands S, Nestorowa S, Hindley CJ, Nichols J, Göttgens B, Huch M, Philpott A, Simons BD. Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development. Developmental Cell. PMID 30057275 DOI: 10.1016/J.Devcel.2018.06.028 |
0.341 |
|
2018 |
McDowell GS, Philpott A. Calculating the Degradation Rate of Individual Proteins Using Extract Systems. Cold Spring Harbor Protocols. PMID 29769400 DOI: 10.1101/Pdb.Prot103481 |
0.635 |
|
2018 |
McDowell GS, Philpott A. Assessing Ubiquitylation of Individual Proteins Using Extract Systems. Cold Spring Harbor Protocols. PMID 29769387 DOI: 10.1101/Pdb.Prot104513 |
0.662 |
|
2018 |
Azzarelli R, Simons BD, Philpott A. The developmental origin of brain tumours: a cellular and molecular framework. Development (Cambridge, England). 145. PMID 29759978 DOI: 10.1242/Dev.162693 |
0.372 |
|
2018 |
Gillotin S, Davies JD, Philpott A. Subcellular localisation modulates ubiquitylation and degradation of Ascl1. Scientific Reports. 8: 4625. PMID 29545540 DOI: 10.1038/S41598-018-23056-4 |
0.395 |
|
2018 |
Philpott A, Ali F, Wylie L, Corchado DM, Chernukhin I, Papachristou E, Papkovskaia T, Lee L, Weekes C, Hiscock T, D'Santos C, Turner S, Carroll J. Abstract SY28-02: A phosphorylation switch regulating proliferation and differentiation in Xenopus development and neuroblastoma Tumor Biology. DOI: 10.1158/1538-7445.Am2018-Sy28-02 |
0.383 |
|
2017 |
Azzarelli R, Hurley C, Sznurkowska MK, Rulands S, Hardwick L, Gamper I, Ali F, McCracken L, Hindley C, McDuff F, Nestorowa S, Kemp R, Jones K, Göttgens B, Huch M, ... ... Philpott A, et al. Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation. Developmental Cell. PMID 28457793 DOI: 10.1016/J.Devcel.2017.04.004 |
0.48 |
|
2016 |
Hardwick LJ, Davies JD, Philpott A. MyoD phosphorylation on multiple C terminal sites regulates myogenic conversion activity. Biochemical and Biophysical Research Communications. PMID 27823936 DOI: 10.1016/J.Bbrc.2016.11.009 |
0.48 |
|
2016 |
McDowell GS, Philpott A. Ubiquitin-mediated proteolysis in Xenopus extract. The International Journal of Developmental Biology. PMID 27528041 DOI: 10.1387/Ijdb.160186Gm |
0.68 |
|
2016 |
McDowell GS, Philpott A. New Insights Into the Role of Ubiquitylation of Proteins. International Review of Cell and Molecular Biology. 325: 35-88. PMID 27241218 DOI: 10.1016/Bs.Ircmb.2016.02.002 |
0.67 |
|
2016 |
Tomic G, Winton DJ, Philpott A. Abstract B30: Regulation of proliferation and differentiation by atonal homolog 1 phosphorylation Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Devbiolca15-B30 |
0.454 |
|
2016 |
McDowell GS, Philpott A. New Insights Into the Role of Ubiquitylation of Proteins International Review of Cell and Molecular Biology. DOI: 10.1016/bs.ircmb.2016.02.002 |
0.613 |
|
2015 |
Philpott A. Multi-site phospho-regulation of proneural transcription factors controls proliferation versus differentiation in development and reprogramming. Neurogenesis (Austin, Tex.). 2: e1049733. PMID 27502783 DOI: 10.1080/23262133.2015.1049733 |
0.389 |
|
2015 |
Hardwick LJ, Philpott A. Multi-site phosphorylation regulates NeuroD4 activity during primary neurogenesis: a conserved mechanism amongst proneural proteins. Neural Development. 10: 15. PMID 26084567 DOI: 10.1186/S13064-015-0044-8 |
0.519 |
|
2015 |
Wylie LA, Hardwick LJ, Papkovskaia TD, Thiele CJ, Philpott A. Ascl1 phospho-status regulates neuronal differentiation in a Xenopus developmental model of neuroblastoma. Disease Models & Mechanisms. 8: 429-41. PMID 25786414 DOI: 10.1242/Dev.125153 |
0.45 |
|
2015 |
Hardwick LJ, Philpott A. An oncologist׳s friend: How Xenopus contributes to cancer research. Developmental Biology. PMID 25704511 DOI: 10.1016/J.Ydbio.2015.02.003 |
0.371 |
|
2015 |
Azzarelli R, Hardwick LJ, Philpott A. Emergence of neuronal diversity from patterning of telencephalic progenitors. Wiley Interdisciplinary Reviews. Developmental Biology. 4: 197-214. PMID 25619507 DOI: 10.1002/Wdev.174 |
0.366 |
|
2015 |
Hardwick LJ, Ali FR, Azzarelli R, Philpott A. Cell cycle regulation of proliferation versus differentiation in the central nervous system. Cell and Tissue Research. 359: 187-200. PMID 24859217 DOI: 10.1007/S00441-014-1895-8 |
0.466 |
|
2014 |
McDowell GS, Hindley CJ, Lippens G, Landrieu I, Philpott A. Phosphorylation in intrinsically disordered regions regulates the activity of Neurogenin2. Bmc Biochemistry. 15: 24. PMID 25374254 DOI: 10.1186/S12858-014-0024-3 |
0.695 |
|
2014 |
Philpott A, Winton DJ. Lineage selection and plasticity in the intestinal crypt. Current Opinion in Cell Biology. 31: 39-45. PMID 25083805 DOI: 10.1016/J.Ceb.2014.07.002 |
0.357 |
|
2014 |
McDowell GS, Hardwick LJ, Philpott A. Complex domain interactions regulate stability and activity of closely related proneural transcription factors. Biochemical and Biophysical Research Communications. 450: 1283-90. PMID 24998442 DOI: 10.1016/J.Bbrc.2014.06.127 |
0.702 |
|
2014 |
Ali FR, Cheng K, Kirwan P, Metcalfe S, Livesey FJ, Barker RA, Philpott A. The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro. Development (Cambridge, England). 141: 2216-24. PMID 24821983 DOI: 10.1242/Dev.106377 |
0.462 |
|
2014 |
Hardwick LJ, Philpott A. Nervous decision-making: to divide or differentiate. Trends in Genetics : Tig. 30: 254-61. PMID 24791612 DOI: 10.1016/J.Tig.2014.04.001 |
0.436 |
|
2013 |
McDowell GS, Philpott A. Non-canonical ubiquitylation: mechanisms and consequences. The International Journal of Biochemistry & Cell Biology. 45: 1833-42. PMID 23732108 DOI: 10.1016/J.Biocel.2013.05.026 |
0.679 |
|
2013 |
Hindley C, Philpott A. The cell cycle and pluripotency. The Biochemical Journal. 451: 135-43. PMID 23535166 DOI: 10.1042/Bj20121627 |
0.391 |
|
2013 |
Wylie LA, Thiele CJ, Philpott A. Abstract 5447: Phosphorylation status of Ascl1 regulates neuroblastoma self-renewal and differentiation. Cancer Research. 73: 5447-5447. DOI: 10.1158/1538-7445.Am2013-5447 |
0.427 |
|
2012 |
Roark R, Itzhaki L, Philpott A. Complex regulation controls Neurogenin3 proteolysis. Biology Open. 1: 1264-72. PMID 23259061 DOI: 10.1242/Bio.20121750 |
0.461 |
|
2012 |
Hindley C, Philpott A. Co-ordination of cell cycle and differentiation in the developing nervous system. The Biochemical Journal. 444: 375-82. PMID 22642576 DOI: 10.1042/Bj20112040 |
0.47 |
|
2012 |
Hindley C, Ali F, McDowell G, Cheng K, Jones A, Guillemot F, Philpott A. Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation. Development (Cambridge, England). 139: 1718-23. PMID 22491944 DOI: 10.1242/Dev.077552 |
0.75 |
|
2011 |
Murai K, Philpott A, Jones PH. Hes6 is required for the neurogenic activity of neurogenin and NeuroD. Plos One. 6: e27880. PMID 22114720 DOI: 10.1371/Journal.Pone.0027880 |
0.46 |
|
2011 |
Ali F, Hindley C, McDowell G, Deibler R, Jones A, Kirschner M, Guillemot F, Philpott A. Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis. Development (Cambridge, England). 138: 4267-77. PMID 21852393 DOI: 10.1242/Dev.067900 |
0.758 |
|
2011 |
Hindley CJ, McDowell GS, Wise H, Philpott A. Regulation of cell fate determination by Skp1-Cullin1-F-box (SCF) E3 ubiquitin ligases. The International Journal of Developmental Biology. 55: 249-60. PMID 21710433 DOI: 10.1387/Ijdb.103171Ch |
0.705 |
|
2010 |
McDowell GS, Kucerova R, Philpott A. Non-canonical ubiquitylation of the proneural protein Ngn2 occurs in both Xenopus embryos and mammalian cells. Biochemical and Biophysical Research Communications. 400: 655-60. PMID 20807509 DOI: 10.1016/J.Bbrc.2010.08.122 |
0.697 |
|
2010 |
Almeida AD, Wise HM, Hindley CJ, Slevin MK, Hartley RS, Philpott A. The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis. Neural Development. 5: 1. PMID 20047651 DOI: 10.1186/1749-8104-5-1 |
0.418 |
|
2009 |
Vosper JM, McDowell GS, Hindley CJ, Fiore-Heriche CS, Kucerova R, Horan I, Philpott A. Ubiquitylation on canonical and non-canonical sites targets the transcription factor neurogenin for ubiquitin-mediated proteolysis. The Journal of Biological Chemistry. 284: 15458-68. PMID 19336407 DOI: 10.1074/Jbc.M809366200 |
0.679 |
|
2008 |
Movassagh M, Philpott A. Cardiac differentiation in Xenopus requires the cyclin-dependent kinase inhibitor, p27Xic1. Cardiovascular Research. 79: 436-47. PMID 18442987 DOI: 10.1093/Cvr/Cvn105 |
0.413 |
|
2008 |
Philpott A, Yew PR. The Xenopus cell cycle: an overview. Molecular Biotechnology. 39: 9-19. PMID 18266114 DOI: 10.1007/S12033-008-9033-Z |
0.439 |
|
2007 |
Nguyen L, Besson A, Heng JI, Schuurmans C, Teboul L, Parras C, Philpott A, Roberts JM, Guillemot F. [p27Kip1 independently promotes neuronal differentiation and migration in the cerebral cortex]. Bulletin Et Mã©Moires De L'Acadã©Mie Royale De Mã©Decine De Belgique. 162: 310-4. PMID 18405000 |
0.607 |
|
2007 |
Boix-Perales H, Horan I, Wise H, Lin HR, Chuang LC, Yew PR, Philpott A. The E3 ubiquitin ligase skp2 regulates neural differentiation independent from the cell cycle. Neural Development. 2: 27. PMID 18081928 DOI: 10.1186/1749-8104-2-27 |
0.456 |
|
2007 |
Murai K, Vernon AE, Philpott A, Jones P. Hes6 is required for MyoD induction during gastrulation. Developmental Biology. 312: 61-76. PMID 17950722 DOI: 10.1016/J.Ydbio.2007.09.011 |
0.386 |
|
2007 |
Vosper JM, Fiore-Heriche CS, Horan I, Wilson K, Wise H, Philpott A. Regulation of neurogenin stability by ubiquitin-mediated proteolysis. The Biochemical Journal. 407: 277-84. PMID 17623011 DOI: 10.1042/Bj20070064 |
0.463 |
|
2007 |
Cosgrove RA, Philpott A. Cell cycling and differentiation do not require the retinoblastoma protein during early Xenopus development. Developmental Biology. 303: 311-24. PMID 17188261 DOI: 10.1016/J.Ydbio.2006.11.015 |
0.449 |
|
2006 |
Nguyen L, Besson A, Heng JI, Schuurmans C, Teboul L, Parras C, Philpott A, Roberts JM, Guillemot F. p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes & Development. 20: 1511-24. PMID 16705040 DOI: 10.1101/Gad.377106 |
0.638 |
|
2006 |
Vernon AE, Movassagh M, Horan I, Wise H, Ohnuma S, Philpott A. Notch targets the Cdk inhibitor Xic1 to regulate differentiation but not the cell cycle in neurons. Embo Reports. 7: 643-8. PMID 16648822 DOI: 10.1038/Sj.Embor.7400691 |
0.635 |
|
2006 |
Lin HR, Chuang LC, Boix-Perales H, Philpott A, Yew PR. Ubiquitination of cyclin-dependent kinase inhibitor, Xic1, is mediated by the Xenopus F-box protein xSkp2. Cell Cycle (Georgetown, Tex.). 5: 304-14. PMID 16410731 DOI: 10.4161/Cc.5.3.2394 |
0.434 |
|
2005 |
Sangrithi MN, Bernal JA, Madine M, Philpott A, Lee J, Dunphy WG, Venkitaraman AR. Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome. Cell. 121: 887-98. PMID 15960976 DOI: 10.1016/J.Cell.2005.05.015 |
0.359 |
|
2005 |
Philpott A, Yew PR. The Xenopus cell cycle: an overview. Methods in Molecular Biology (Clifton, N.J.). 296: 95-112. PMID 15576928 DOI: 10.1385/1-59259-857-9:095 |
0.438 |
|
2004 |
Richard-Parpaillon L, Cosgrove RA, Devine C, Vernon AE, Philpott A. G1/S phase cyclin-dependent kinase overexpression perturbs early development and delays tissue-specific differentiation in Xenopus. Development (Cambridge, England). 131: 2577-86. PMID 15115752 DOI: 10.1242/Dev.01121 |
0.41 |
|
2003 |
Vernon AE, Philpott A. The developmental expression of cell cycle regulators in Xenopus laevis. Gene Expression Patterns : Gep. 3: 179-92. PMID 12711547 DOI: 10.1016/S1567-133X(03)00006-1 |
0.326 |
|
2003 |
Cremisi F, Philpott A, Ohnuma S. Cell cycle and cell fate interactions in neural development. Current Opinion in Neurobiology. 13: 26-33. PMID 12593979 DOI: 10.1016/S0959-4388(03)00005-9 |
0.592 |
|
2003 |
Vernon AE, Devine C, Philpott A. The cdk inhibitor p27Xic1 is required for differentiation of primary neurones in Xenopus. Development (Cambridge, England). 130: 85-92. PMID 12441293 DOI: 10.1242/Dev.00193 |
0.439 |
|
2003 |
Vernon AE, Philpott A. A single cdk inhibitor, p27Xic1, functions beyond cell cycle regulation to promote muscle differentiation in Xenopus. Development (Cambridge, England). 130: 71-83. PMID 12441292 DOI: 10.1242/Dev.00180 |
0.428 |
|
2002 |
Ohnuma S, Hopper S, Wang KC, Philpott A, Harris WA. Co-ordinating retinal histogenesis: early cell cycle exit enhances early cell fate determination in the Xenopus retina. Development (Cambridge, England). 129: 2435-46. PMID 11973275 |
0.57 |
|
2002 |
Cossins J, Vernon AE, Zhang Y, Philpott A, Jones PH. Hes6 regulates myogenic differentiation. Development (Cambridge, England). 129: 2195-207. PMID 11959828 DOI: 10.1042/Cs103044Pa |
0.506 |
|
2001 |
Ohnuma S, Philpott A, Harris WA. Cell cycle and cell fate in the nervous system. Current Opinion in Neurobiology. 11: 66-73. PMID 11179874 DOI: 10.1016/S0959-4388(00)00175-6 |
0.611 |
|
2000 |
Philpott A, Krude T, Laskey RA. Nuclear chaperones. Seminars in Cell & Developmental Biology. 11: 7-14. PMID 10736259 DOI: 10.1006/Scdb.1999.0346 |
0.734 |
|
1999 |
Ohnuma S, Philpott A, Wang K, Holt CE, Harris WA. p27Xic1, a Cdk inhibitor, promotes the determination of glial cells in Xenopus retina. Cell. 99: 499-510. PMID 10589678 DOI: 10.1016/S0092-8674(00)81538-X |
0.587 |
|
1999 |
Philpott A, Tsai L, Kirschner MW. Neuronal differentiation and patterning in Xenopus: the role of cdk5 and a novel activator xp35.2. Developmental Biology. 207: 119-32. PMID 10049569 DOI: 10.1006/Dbio.1998.9146 |
0.567 |
|
1997 |
Philpott A, Porro EB, Kirschner MW, Tsai LH. The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning. Genes & Development. 11: 1409-21. PMID 9192869 DOI: 10.1101/Gad.11.11.1409 |
0.555 |
|
1997 |
Crevel G, Huikeshoven H, Cotterill S, Simon M, Wall J, Philpott A, Laskey RA, McConnell M, Fisher PA, Berrios M. Molecular and cellular characterization of CRP1, a Drosophila chromatin decondensation protein. Journal of Structural Biology. 118: 9-22. PMID 9087911 DOI: 10.1006/Jsbi.1996.3836 |
0.603 |
|
1996 |
Leno GH, Mills AD, Philpott A, Laskey RA. Hyperphosphorylation of nucleoplasmin facilitates Xenopus sperm decondensation at fertilization. The Journal of Biological Chemistry. 271: 7253-6. PMID 8631735 DOI: 10.1074/Jbc.271.13.7253 |
0.611 |
|
1994 |
Philpott A, Friend SH. E2F and its developmental regulation in Xenopus laevis. Molecular and Cellular Biology. 14: 5000-9. PMID 8007993 DOI: 10.1128/Mcb.14.7.5000 |
0.438 |
|
1993 |
Laskey RA, Mills AD, Philpott A, Leno GH, Dilworth SM, Dingwall C. The role of nucleoplasmin in chromatin assembly and disassembly. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 339: 263-9; discussion 26. PMID 8098530 DOI: 10.1098/Rstb.1993.0024 |
0.614 |
|
1992 |
Philpott A, Leno GH. Nucleoplasmin remodels sperm chromatin in Xenopus egg extracts. Cell. 69: 759-67. PMID 1591776 DOI: 10.1016/0092-8674(92)90288-N |
0.319 |
|
1991 |
Philpott A, Leno GH, Laskey RA. Sperm decondensation in Xenopus egg cytoplasm is mediated by nucleoplasmin. Cell. 65: 569-78. PMID 2032284 DOI: 10.1016/0092-8674(91)90089-H |
0.589 |
|
1991 |
Laskey RA, Cox LS, Leno GH, Philpott A, Mills AD, Sleeman AM. Control of DNA replication in reconstituted nuclei. Cold Spring Harbor Symposia On Quantitative Biology. 56: 347-52. PMID 1819495 DOI: 10.1101/Sqb.1991.056.01.041 |
0.521 |
|
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