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Edward B. Skibo - Publications

Affiliations: 
Arizona State University, Tempe, AZ, United States 
Area:
Organic Chemistry
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48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2013 LaBarbera DV, Skibo EB. The synthesis of vinylogous amidine heterocycles. The Journal of Organic Chemistry. 78: 11887-95. PMID 24228868 DOI: 10.1021/Jo401927N  0.377
2010 Skibo EB, Jamil A, Austin B, Hansen D, Ghodousi A. Triple molecular target approach to selective melanoma cytotoxicity. Organic & Biomolecular Chemistry. 8: 1577-87. PMID 20237668 DOI: 10.1039/B920260A  0.343
2009 Khdour O, Skibo EB. Quinone methide chemistry of prekinamycins: 13C-labeling, spectral global fitting and in vitro studies. Organic & Biomolecular Chemistry. 7: 2140-54. PMID 19421453 DOI: 10.1039/B903844B  0.331
2008 Hoang H, Huang X, Skibo EB. Synthesis and in vitro evaluation of imidazole-based wakayin analogues. Organic & Biomolecular Chemistry. 6: 3059-64. PMID 18698463 DOI: 10.1039/B806883F  0.68
2008 Hargreaves RH, David CL, Whitesell LJ, Labarbera DV, Jamil A, Chapuis JC, Skibo EB. Discovery of quinolinediones exhibiting a heat shock response and angiogenesis inhibition. Journal of Medicinal Chemistry. 51: 2492-501. PMID 18363347 DOI: 10.1021/Jm7014099  0.329
2007 Khdour O, Skibo EB. Chemistry of pyrrolo[1,2-a]indole- and pyrido[1,2-a]indole-based quinone methides. Mechanistic explanations for differences in cytostatic/cytotoxic properties. The Journal of Organic Chemistry. 72: 8636-47. PMID 17927245 DOI: 10.1021/Jo070866O  0.409
2007 Hoang H, LaBarbera DV, Mohammed KA, Ireland CM, Skibo EB. Synthesis and biological evaluation of imidazoquinoxalinones, imidazole analogues of pyrroloiminoquinone marine natural products. Journal of Medicinal Chemistry. 50: 4561-71. PMID 17705462 DOI: 10.1021/Jm0700870  0.693
2006 Khdour O, Ouyang A, Skibo EB. Design of a cyclopropyl quinone methide reductive alkylating agent. 2. The Journal of Organic Chemistry. 71: 5855-63. PMID 16872163 DOI: 10.1021/Jo0602423  0.393
2006 LaBarbera DV, Skibo EB. Solution kinetics of CC-1065 A-ring opening: substituent effects and general acid/base catalysis. Journal of the American Chemical Society. 128: 3722-7. PMID 16536546 DOI: 10.1021/Ja057289A  0.36
2005 Labarbera DV, Skibo EB. Synthesis of imidazo[1,5,4-de]quinoxalin-9-ones, benzimidazole analogues of pyrroloiminoquinone marine natural products. Bioorganic & Medicinal Chemistry. 13: 387-95. PMID 15598560 DOI: 10.1016/J.Bmc.2004.10.016  0.43
2004 Ghodousi A, Huang X, Cheng Z, Skibo EB. Pyrrolobenzimidazoles linked to heterocycles and peptides. Design of DNA base pair specific phosphate hydrolyzing agents and novel cytotoxic agents. Journal of Medicinal Chemistry. 47: 90-100. PMID 14695823 DOI: 10.1021/Jm0302750  0.407
2003 Hargreaves R, David CL, Whitesell L, Skibo EB. Design of quinolinedione-based geldanamycin analogues. Bioorganic & Medicinal Chemistry Letters. 13: 3075-8. PMID 12941337 DOI: 10.1016/S0960-894X(03)00650-4  0.372
2002 Skibo EB, Huang X, Martinez R, Lemus RH, Craigo WA, Dorr RT. Pyrimidoquinazoline-based antitumor agents. Design of topoisomerase II to DNA cross-linkers with activity against protein kinases. Journal of Medicinal Chemistry. 45: 5543-55. PMID 12459022 DOI: 10.1021/Jm020285L  0.353
2002 Suleman A, Skibo EB. A comprehensive study of the active site residues of DT-diaphorase: rational design of benzimidazolediones as DT-diaphorase substrates. Journal of Medicinal Chemistry. 45: 1211-20. PMID 11881990 DOI: 10.1021/Jm0104365  0.326
2001 Skibo EB, Xing C, Dorr RT. Aziridinyl quinone antitumor agents based on indoles and cyclopent[b]indoles: structure-activity relationships for cytotoxicity and antitumor activity. Journal of Medicinal Chemistry. 44: 3545-62. PMID 11606119 DOI: 10.1021/Jm010085U  0.466
2001 Skibo EB, Xing C, Groy T. Recognition and cleavage at the DNA major groove Bioorganic & Medicinal Chemistry. 9: 2445-2459. PMID 11553486 DOI: 10.1016/S0968-0896(01)00219-X  0.369
2000 Huang X, Suleman A, Skibo EB. Rational design of pyrrolo. Bioorganic Chemistry. 28: 324-37. PMID 11352470 DOI: 10.1006/Bioo.2000.1183  0.351
2000 Xing C, Skibo EB. Sigmatropic reactions of the aziridinyl semiquinone species. Why aziridinyl benzoquinones are metabolically more stable than aziridinyl indoloquinones Biochemistry. 39: 10770-10780. PMID 10978162 DOI: 10.1021/Bi000885R  0.37
2000 Ouyang A, Skibo EB. Iminium ion chemistry of mitosene DNA alkylating agents. Enriched 13C NMR and isolation studies Biochemistry. 39: 5817-5830. PMID 10801332 DOI: 10.1021/Bi992882O  0.357
2000 Schulz WG, Skibo EB. Inhibitors of topoisomerase II based on the benzodiimidazole and dipyrroloimidazobenzimidazole ring systems: controlling DT-diaphorase reductive inactivation with steric bulk. Journal of Medicinal Chemistry. 43: 629-638. PMID 10691689 DOI: 10.1021/Jm990210Q  0.401
2000 Xing C, Wu P, Skibo EB, Dorr RT. Design of cancer-specific antitumor agents based on aziridinylcyclopent[b]indoloquinones. Journal of Medicinal Chemistry. 43: 457-66. PMID 10669573 DOI: 10.1021/Jm990466W  0.43
1999 Craigo WA, LeSueur BW, Skibo EB. Design of highly active analogues of the pyrrolo[1,2-a]benzimidazole antitumor agents. Journal of Medicinal Chemistry. 42: 3324-3333. PMID 10464019 DOI: 10.1021/Jm990029H  0.426
1998 Skibo EB, Xing C. Chemistry and DNA alkylation reactions of aziridinyl quinones: Development of an efficient alkylating agent of the phosphate backbone Biochemistry. 37: 15199-15213. PMID 9790684 DOI: 10.1021/Bi981204J  0.389
1998 Skibo EB. Pyrrolobenzimidazoles in cancer treatment Expert Opinion On Therapeutic Patents. 8: 673-701. DOI: 10.1517/13543776.8.6.673  0.447
1997 Skibo EB, Gordon S, Bess L, Boruah R, Heileman MJ. Studies of Pyrrolo[1,2-a]benzimidazolequinone DT-Diaphorase Substrate Activity, Topoisomerase II Inhibition Activity, and DNA Reductive Alkylation Journal of Medicinal Chemistry. 40: 1327-1339. PMID 9135030 DOI: 10.1021/Jm960546P  0.401
1996 Zhou R, Skibo EB. Chemistry of the Pyrrolo[1,2-a]benzimidazole Antitumor Agents: Influence of the 7-Substituent on the Ability To Alkylate DNA and Inhibit Topoisomerase II Journal of Medicinal Chemistry. 39: 4321-4331. PMID 8863809 DOI: 10.1021/Jm960064D  0.372
1995 Schulz WG, Nieman RA, Skibo EB. Evidence for DNA phosphate backbone alkylation and cleavage by pyrrolo[1,2-a]benzimidazoles: small molecules capable of causing base-pair-specific phosphodiester bond hydrolysis Proceedings of the National Academy of Sciences of the United States of America. 92: 11854-11858. PMID 8524862 DOI: 10.1073/Pnas.92.25.11854  0.35
1995 Schulz WG, Islam I, Skibo EB. Pyrrolo[1,2-a]benzimidazole-based quinones and iminoquinones. The role of the 3-substituent on cytotoxicity Journal of Medicinal Chemistry. 38: 109-118. PMID 7837221 DOI: 10.1021/Jm00001A016  0.4
1994 Skibo EB, Islam JI, Heileman MJ, Schulz WG. Structure-Activity Studies of Benzimidazole-Based DNA-Cleaving Agents. Comparison of Benzimidazole, Pyrrolobenzimidazole, and Tetrahydropyridobenzimidazole Analogues Journal of Medicinal Chemistry. 37: 78-92. PMID 8289204 DOI: 10.1021/Jm00027A010  0.47
1994 Boruah RC, Skibo EB. A comparison of the cytotoxic and physical properties of aziridinyl quinone derivatives based on the pyrrolo[1,2-a]benzimidazole and pyrrolo[1,2-a]indole ring systems. Journal of Medicinal Chemistry. 37: 1625-1631. PMID 8201596 DOI: 10.1021/Jm00037A013  0.441
1993 Skibo EB, Schulz WG. Pyrrolo[1,2-a]benzimidazole-based aziridinyl quinones. A new class of DNA cleaving agent exhibiting G and A base specificity. Journal of Medicinal Chemistry. 36: 3050-3055. PMID 8230090 DOI: 10.1021/Jm00073A002  0.426
1993 Dempcy RO, Skibo EB. Kinetic studies of 2-(2′-haloethyl) and 2-ethenyl substituted quinazolinone alkylating agents. Acid-catalyzed dehydrohalogenation and alkylation involving a quinazolinone prototropic tautomer Bioorganic & Medicinal Chemistry. 1: 39-43. PMID 8081836 DOI: 10.1016/S0968-0896(00)82101-X  0.387
1993 Boruah RC, Skibo EB. A mechanistic study of 2-vinylbenzimidazole formation from 2-(2'-haloethyl)benzimidazoles. Synthesis of highly electron-rich vinylic compounds by general base and specific acid-general base catalysis Journal of Organic Chemistry. 58: 7797-7803. DOI: 10.1021/Jo00079A025  0.362
1992 Lemus RH, Skibo EB. Design of pyrimido[4,5-g]quinazoline-based anthraquinone mimics. Structure-activity relationship for quinone methide formation and the influence of internal hydrogen bonds on quinone methide fate Journal of Organic Chemistry. 57: 5649-5660. DOI: 10.1021/Jo00047A017  0.39
1992 Dempcy RO, Skibo EB. Rational design of purine nucleoside phosphorylase inhibitors: Design of 2-(2′-Haloethyl) and 2-ethenyl substituted quinazolinone alkylating agents. Bioorganic & Medicinal Chemistry Letters. 2: 1427-1434. DOI: 10.1016/S0960-894X(00)80526-0  0.445
1991 Islam I, Skibo EB, Dorr RT, Alberts DS. Structure-activity studies of antitumor agents based on pyrrolo[1,2-a]benzimidazoles: new reductive alkylating DNA cleaving agents. Journal of Medicinal Chemistry. 34: 2954-61. PMID 1920349 DOI: 10.1021/Jm00114A003  0.43
1991 Dempcy RO, Skibo EB. Rational design of quinazoline-based irreversible inhibitors of human erythrocyte purine nucleoside phosphorylase. Biochemistry. 30: 8480-8487. PMID 1909177 DOI: 10.1021/Bi00098A028  0.374
1991 Dempcy RO, Skibo EB. Regioselective synthesis of imidazo[4,5-g]quinazoline quinone nucleosides and quinazoline amino nucleosides. Studies of their xanthine oxidase and purine nucleoside phosphorylase substrate activity Journal of Organic Chemistry. 56: 776-785. DOI: 10.1021/Jo00002A052  0.383
1990 Islam I, Skibo EB. Synthesis and physical studies of azamitosene and iminoazamitosene reductive alkylating agents. Iminoquinone hydrolytic stability, syn/anti isomerization, and electrochemistry Journal of Organic Chemistry. 55: 3195-3205. DOI: 10.1021/Jo00297A040  0.379
1989 Lemus RH, Lee CH, Skibo EB. Studies of extended quinone methides. Synthesis and physical studies of purine-like monofunctional and bifunctional imidazo[4,5-g]quinazoline reductive alkylating agents Journal of Organic Chemistry. 54: 3611-3618. DOI: 10.1021/Jo00276A022  0.344
1988 Lemus RH, Skibo EB. Studies of extended quinone methides. Design of reductive alkylating agents based on the quinazoline ring system Journal of Organic Chemistry. 53: 6099-6105. DOI: 10.1021/Jo00261A021  0.375
1988 Skibo EB, Gilchrist JH. Synthesis and electrochemistry of pyrimidoquinazoline-5,10-diones. Design of hydrolytically stable high potential quinones and new reductive alkylation systems Journal of Organic Chemistry. 53: 4209-4218. DOI: 10.1021/Jo00253A010  0.304
1987 Skibo EB, Gilchrist JH, Lee CH. Electronic probes of the mechanism of substrate oxidation by buttermilk xanthine oxidase: role of the active-site nucleophile in oxidation Biochemistry. 26: 3032-3037. PMID 3607009 DOI: 10.1021/Bi00385A013  0.329
1987 Lee CH, Skibo EB. Active-site-directed reductive alkylation of xanthine oxidase by imidazo[4,5-g]quinazoline-4,9-diones functionalized with a leaving group. Biochemistry. 26: 7355-7362. PMID 3427077 DOI: 10.1021/Bi00397A024  0.413
1986 Skibo EB. Noncompetitive and irreversible inhibition of xanthine oxidase by benzimidazole analogues acting at the functional flavin adenine dinucleotide cofactor. Biochemistry. 25: 4189-4194. PMID 3756135 DOI: 10.1021/Bi00363A004  0.359
1986 Lee CH, Gilchrist JH, Skibo EB. Synthesis, electrochemistry, and xanthine oxidase substrate reactivity of imidazo[4,5-g]quinazoline-4,9-diones. Studies directed toward the design of purine-like reductive alkylators Journal of Organic Chemistry. 51: 4784-4792. DOI: 10.1021/Jo00375A007  0.357
1981 Skibo EB, Meyer RB. Inhibition of inosinic acid dehydrogenase by 8-substituted purine nucleotides. Journal of Medicinal Chemistry. 24: 1155-61. PMID 6120232 DOI: 10.1021/Jm00142A007  0.401
1979 Meyer RB, Skibo EB. Synthesis of fused [1,2,6]thiadiazine 1,1-dioxides as potential transition-state analogue inhibitors of xanthine oxidase and guanase. Journal of Medicinal Chemistry. 22: 944-8. PMID 490539 DOI: 10.1021/Jm00194A011  0.379
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