Paul H. Axelsen - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Pharmacology, Cell Biology, Molecular Biology

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Furman R, Ng SCW, Komatsu H, Axelsen PH. Quantitative Mass Spectrometric Assay of Whole and CNBr-Cleaved Amyloid-β Peptides in Human Brain. Journal of Alzheimer's Disease : Jad. PMID 31958092 DOI: 10.3233/Jad-190647  0.373
2020 Furman R, Ng SCW, Komatsu H, Axelsen PH. Quantitative Mass Spectrometric Assay of Amyloid Beta Peptide Variants with N- and C-Terminal Truncations and Modifications in Human Brain Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1206  0.312
2018 Raefsky SM, Furman R, Milne G, Pollock E, Axelsen P, Mattson MP, Shchepinov MS. Deuterated polyunsaturated fatty acids reduce brain lipid peroxidation and hippocampal amyloid β-peptide levels, without discernable behavioral effects in an APP/PS1 mutant transgenic mouse model of Alzheimer's disease. Neurobiology of Aging. 66: 165-176. PMID 29579687 DOI: 10.1016/J.Neurobiolaging.2018.02.024  0.328
2018 Eskici G, Axelsen PH. Mass Exchange and Equilibration Processes in AOT Reverse Micelles. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 29364686 DOI: 10.1021/Acs.Langmuir.7B04192  0.348
2017 Grasso G, Komatsu H, Axelsen PH. Covalent modifications of the amyloid beta peptide by hydroxynonenal: Effects on metal ion binding by monomers and insights into the fibril topology. Journal of Inorganic Biochemistry. 174: 130-136. PMID 28668508 DOI: 10.1016/J.Jinorgbio.2017.06.007  0.348
2017 Eskici G, Axelsen PH. Amyloid Beta Peptide Folding in Reverse Micelles. Journal of the American Chemical Society. PMID 28631483 DOI: 10.1021/Jacs.7B03333  0.421
2017 Komatsu H, Meurice C, Grasso G, Lippert LG, Goldman YE, Axelsen PH. Variable Binding of Thioflavin T by Amyloid Fibrils Biophysical Journal. 112: 1-8. DOI: 10.1016/J.Bpj.2016.11.1098  0.337
2016 Grasso G, Axelsen PH. Effects of Covalent Modification by 4-hydroxy-2-nonenal on the Noncovalent Oligomerization of Ubiquitin. Journal of Mass Spectrometry : Jms. PMID 27862610 DOI: 10.1002/Jms.3897  0.351
2016 Komatsu H, Axelsen PH. Amyloid Beta-Protein Fibrils from Human Alzheimer's Brain Tissue and from Mouse Models of Alzheimer's Differ in Structures Biophysical Journal. 110: 2-9. DOI: 10.1016/J.Bpj.2015.11.1214  0.314
2015 Eskici G, Axelsen P. Amyloid Fibril Nucleation In Reverse Micelles Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.389  0.385
2015 Komatsu H, Axelsen PH. Structural Variations of Amyloid β-Protein Fibrils Seeded with Extracted Fibrils from Brain Tissue of Alzheimer's Disease Model Mice Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.2880  0.323
2014 Klinger AL, Kiselar J, Ilchenko S, Komatsu H, Chance MR, Axelsen PH. A synchrotron-based hydroxyl radical footprinting analysis of amyloid fibrils and prefibrillar intermediates with residue-specific resolution. Biochemistry. 53: 7724-34. PMID 25382225 DOI: 10.1021/Bi5010409  0.382
2014 Ma J, Komatsu H, Axelsen PH. Two-Dimensional Infrared Spectroscopy and Electron Microscopy of Seeded and Non-Seeded Amyloid β Peptide Fibrils Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.3764  0.333
2013 Ma J, Komatsu H, Kim YS, Liu L, Hochstrasser RM, Axelsen PH. Intrinsic structural heterogeneity and long-term maturation of amyloid β peptide fibrils. Acs Chemical Neuroscience. 4: 1236-43. PMID 23701594 DOI: 10.1021/Cn400092V  0.367
2013 Yeung PS, Eskici G, Axelsen PH. Infrared spectroscopy of proteins in reverse micelles. Biochimica Et Biophysica Acta. 1828: 2314-8. PMID 23098833 DOI: 10.1016/J.Bbamem.2012.10.019  0.401
2013 Eskici G, Axelsen P. Simulated Amyloid Fibril Nucleation in Reverse Micelles Biophysical Journal. 104: 5-6. DOI: 10.1016/J.Bpj.2012.11.3141  0.341
2013 Komatsu H, Axelsen PH. Copper Ion Induces N-Terminal β Structure in Amyloid β Protein in Reverse Micelles Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.3134  0.362
2012 Yeung PS, Axelsen PH. The crowded environment of a reverse micelle induces the formation of β-strand seed structures for nucleating amyloid fibril formation. Journal of the American Chemical Society. 134: 6061-3. PMID 22448820 DOI: 10.1021/Ja3004478  0.354
2012 Yeung P, Komatsu H, Axelsen PH. Monomeric Amyloid β Proteins in Reverse Micelles are in Folded β Sheet Structure Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.2498  0.356
2012 Eskici G, Axelsen PH. Water Penetration into a Dry Amyloid Fibril Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1404  0.327
2012 Klinger AL, Axelsen PH. Oxidative Footprinting of Fibrillar and Prefibrillar Oligomer Forms of Amyloid Beta Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1333  0.339
2011 Haque ME, Chakraborty H, Koklic T, Komatsu H, Axelsen PH, Lentz BR. Hemagglutinin fusion peptide mutants in model membranes: structural properties, membrane physical properties, and PEG-mediated fusion. Biophysical Journal. 101: 1095-104. PMID 21889446 DOI: 10.1016/J.Bpj.2011.07.031  0.503
2011 Axelsen PH, Komatsu H, Murray IV. Oxidative stress and cell membranes in the pathogenesis of Alzheimer's disease. Physiology (Bethesda, Md.). 26: 54-69. PMID 21357903 DOI: 10.1152/Physiol.00024.2010  0.434
2011 Komatsu H, Axelsen PH. Topology of His Residues in Amyloid β Protein Fibrils Biophysical Journal. 100: 2-3. DOI: 10.1016/J.Bpj.2010.12.1320  0.467
2010 Komatsu H, Feingold-Link E, Sharp KA, Rastogi T, Axelsen PH. Intrinsic linear heterogeneity of amyloid β protein fibrils revealed by higher resolution mass-per-length determinations. The Journal of Biological Chemistry. 285: 41843-51. PMID 20940298 DOI: 10.1074/Jbc.M110.165068  0.341
2010 Axelsen PH, Murphy RC. Quantitative analysis of phospholipids containing arachidonate and docosahexaenoate chains in microdissected regions of mouse brain. Journal of Lipid Research. 51: 660-71. PMID 19767534 DOI: 10.1194/Jlr.D001750  0.33
2009 Loll PJ, Derhovanessian A, Shapovalov MV, Kaplan J, Yang L, Axelsen PH. Vancomycin forms ligand-mediated supramolecular complexes. Journal of Molecular Biology. 385: 200-11. PMID 18983853 DOI: 10.1016/J.Jmb.2008.10.049  0.307
2009 Komatsu H, Liu L, Axelsen PH. Amyloid β Proteins, Modified by a Lipid Oxidation Product, Are Nucleation Sites for Fibril Formation on Lipid Membranes Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.310  0.482
2008 Kim YS, Liu L, Axelsen PH, Hochstrasser RM. Two-dimensional infrared spectra of isotopically diluted amyloid fibrils from Abeta40. Proceedings of the National Academy of Sciences of the United States of America. 105: 7720-5. PMID 18499799 DOI: 10.1073/Pnas.0802993105  0.31
2008 Liu L, Komatsu H, Murray IV, Axelsen PH. Promotion of amyloid beta protein misfolding and fibrillogenesis by a lipid oxidation product. Journal of Molecular Biology. 377: 1236-50. PMID 18304576 DOI: 10.1016/J.Jmb.2008.01.057  0.436
2008 Axelsen PH. A chaotic pore model of polypeptide antibiotic action. Biophysical Journal. 94: 1549-50. PMID 18065456 DOI: 10.1529/Biophysj.107.124792  0.45
2007 Komatsu H, Liu L, Murray IV, Axelsen PH. A mechanistic link between oxidative stress and membrane mediated amyloidogenesis revealed by infrared spectroscopy. Biochimica Et Biophysica Acta. 1768: 1913-22. PMID 17632073 DOI: 10.1016/J.Bbamem.2007.05.026  0.429
2007 MacDonald ML, Murray IV, Axelsen PH. Mass spectrometric analysis demonstrates that BODIPY 581/591 C11 overestimates and inhibits oxidative lipid damage. Free Radical Biology & Medicine. 42: 1392-7. PMID 17395012 DOI: 10.1016/J.Freeradbiomed.2007.01.038  0.336
2007 Silva RAGD, Schneeweis LA, Krishnan SC, Zhang X, Axelsen PH, Davidson WS. The structure of apolipoprotein A-II in discoidal high density lipoproteins Journal of Biological Chemistry. 282: 9713-9721. PMID 17264082 DOI: 10.1074/Jbc.M610380200  0.321
2007 Murray IV, Liu L, Komatsu H, Uryu K, Xiao G, Lawson JA, Axelsen PH. Membrane-mediated amyloidogenesis and the promotion of oxidative lipid damage by amyloid beta proteins. The Journal of Biological Chemistry. 282: 9335-45. PMID 17255094 DOI: 10.1074/Jbc.M608589200  0.458
2006 Londergan CH, Wang J, Axelsen PH, Hochstrasser RM. Two-dimensional infrared spectroscopy displays signatures of structural ordering in peptide aggregates. Biophysical Journal. 90: 4672-85. PMID 16565049 DOI: 10.1529/Biophysj.105.075812  0.44
2005 Haque ME, Koppaka V, Axelsen PH, Lentz BR. Properties and structures of the influenza and HIV fusion peptides on lipid membranes: implications for a role in fusion. Biophysical Journal. 89: 3183-94. PMID 16183890 DOI: 10.1529/Biophysj.105.063032  0.465
2005 Murray IV, Sindoni ME, Axelsen PH. Promotion of oxidative lipid membrane damage by amyloid beta proteins. Biochemistry. 44: 12606-13. PMID 16156673 DOI: 10.1021/Bi050926P  0.394
2005 Paul C, Axelsen PH. beta Sheet structure in amyloid beta fibrils and vibrational dipolar coupling. Journal of the American Chemical Society. 127: 5754-5. PMID 15839650 DOI: 10.1021/Ja042569W  0.33
2004 Jusuf S, Axelsen PH. Synchronized conformational fluctuations and binding site desolvation during molecular recognition. Biochemistry. 43: 15446-52. PMID 15581356 DOI: 10.1021/Bi048357T  0.319
2004 Paul C, Wang J, Wimley WC, Hochstrasser RM, Axelsen PH. Vibrational coupling, isotopic editing, and beta-sheet structure in a membrane-bound polypeptide. Journal of the American Chemical Society. 126: 5843-50. PMID 15125676 DOI: 10.1021/Ja038869F  0.438
2004 Murray IV, Paul C, Axelsen PH. P4-243 Accelerated misfolding of amyloid beta protein by oxidized lipids Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81801-3  0.34
2003 Koppaka V, Paul C, Murray IV, Axelsen PH. Early synergy between Abeta42 and oxidatively damaged membranes in promoting amyloid fibril formation by Abeta40. The Journal of Biological Chemistry. 278: 36277-84. PMID 12821671 DOI: 10.1074/Jbc.M301334200  0.436
2003 Hong RW, Shchepetov M, Weiser JN, Axelsen PH. Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A. Antimicrobial Agents and Chemotherapy. 47: 1-6. PMID 12499161 DOI: 10.1128/Aac.47.1.1-6.2003  0.394
2001 Kaplan J, Korty BD, Axelsen PH, Loll PJ. The role of sugar residues in molecular recognition by vancomycin Journal of Medicinal Chemistry. 44: 1837-1840. PMID 11356118 DOI: 10.1021/Jm0005306  0.312
2001 Pender BA, Wu X, Axelsen PH, Cooperman BS. Toward a rational design of peptide inhibitors of ribonucleotide reductase: structure-function and modeling studies. Journal of Medicinal Chemistry. 44: 36-46. PMID 11141086 DOI: 10.1021/Jm000335R  0.304
2001 Koppaka V, Axelsen PH. Evanescent electric field amplitudes in thin lipid films for internal reflection infrared spectroscopy Langmuir. 17: 6309-6316. DOI: 10.1021/La010731S  0.336
2000 Silvestro L, Axelsen PH. Membrane-Induced Folding of Cecropin A Biophysical Journal. 79: 1465-1477. PMID 10969008 DOI: 10.1016/S0006-3495(00)76398-3  0.79
2000 Koppaka V, Axelsen PH. Accelerated accumulation of amyloid β proteins on oxidatively damaged lipid membranes Biochemistry. 39: 10011-10016. PMID 10933822 DOI: 10.1021/Bi000619D  0.454
2000 Weinstein EA, Li H, Lawson JA, Rokach J, FitzGerald GA, Axelsen PH. Prothrombinase acceleration by oxidatively damaged phospholipids. The Journal of Biological Chemistry. 275: 22925-30. PMID 10801844 DOI: 10.1074/Jbc.M002438200  0.411
2000 Silvestro L, Weiser JN, Axelsen PH. Antibacterial and antimembrane activities of cecropin A in Escherichia coli Antimicrobial Agents and Chemotherapy. 44: 602-607. PMID 10681325 DOI: 10.1128/Aac.44.3.602-607.2000  0.763
2000 Koppaka V, Weinstein E, Axelsen PH. Accelerated β amyloid nucleation by oxidatively damaged lipid membranes Neurobiology of Aging. 21: 9. DOI: 10.1016/S0197-4580(00)82717-7  0.435
1999 Koppaka V, Axelsen PH. Lipoprotein A-I structure Trends in Cardiovascular Medicine. 9: 192-195. PMID 10881750 DOI: 10.1016/S1050-1738(00)00024-4  0.377
1999 Koppaka V, Silvestro L, Engler JA, Brouillette CG, Axelsen PH. The structure of human lipoprotein A-I. Evidence for the "belt" model. The Journal of Biological Chemistry. 274: 14541-4. PMID 10329643 DOI: 10.1074/Jbc.274.21.14541  0.755
1999 Silvestro L, Axelsen PH. Fourier transform infrared linked analysis of conformational changes in annexin V upon membrane binding. Biochemistry. 38: 113-121. PMID 9890889 DOI: 10.1021/Bi981289O  0.774
1998 Silvestro L, Axelsen PH. Infrared spectroscopy of supported lipid monolayer, bilayer, and multibilayer membranes Chemistry and Physics of Lipids. 96: 69-80. PMID 9871983 DOI: 10.1016/S0009-3084(98)00081-4  0.787
1998 Loll PJ, Miller R, Weeks CM, Axelsen PH. A ligand-mediated dimerization mode for vancomycin Chemistry & Biology. 5: 293-298. PMID 9578636 DOI: 10.1016/S1074-5521(98)90622-6  0.335
1998 Wimley WC, Hristova K, Ladokhin AS, Silvestro L, Axelsen PH, White SH. Folding of β-sheet membrane proteins: A hydrophobic hexapeptide model Journal of Molecular Biology. 277: 1091-1110. PMID 9571025 DOI: 10.1006/Jmbi.1998.1640  0.784
1997 Li D, Sreenivasan U, Juranic N, Macura S, Puga FJ, Frohnert PM, Axelsen PH. Simulated dipeptide recognition by vancomycin. Journal of Molecular Recognition : Jmr. 10: 73-87. PMID 9376130 DOI: 10.1002/(Sici)1099-1352(199703/04)10:2<73::Aid-Jmr347>3.0.Co;2-1  0.311
1997 Silvestro L, Gupta K, Weiser JN, Axelsen PH. The concentration-dependent membrane activity of cecropin A Biochemistry. 36: 11452-11460. PMID 9298965 DOI: 10.1021/Bi9630826  0.775
1996 Citra MJ, Axelsen PH. Determination of molecular order in supported lipid membranes by internal reflection Fourier transform infrared spectroscopy Biophysical Journal. 71: 1796-1805. PMID 8889156 DOI: 10.1016/S0006-3495(96)79380-3  0.446
1995 Axelsen PH, Kaufman BK, Mcelhaney RN, Lewis RNAH. The infrared dichroism of transmembrane helical polypeptides Biophysical Journal. 69: 2770-2781. PMID 8599683 DOI: 10.1016/S0006-3495(95)80150-5  0.419
1995 Axelsen PH, Braddock WD, Brockman HL, Jones CM, Dluhy RA, Kaufman BK, Puga FJ. Use of Internal Reflectance Infrared Spectroscopy for thein SituStudy of Supported Lipid Monolayers Applied Spectroscopy. 49: 526-531. DOI: 10.1366/0003702953964273  0.375
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