Paul H. Axelsen - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Pharmacology, Cell Biology, Molecular Biology

63/121 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Furman R, Ng SCW, Komatsu H, Axelsen PH. Quantitative Mass Spectrometric Assay of Whole and CNBr-Cleaved Amyloid-β Peptides in Human Brain. Journal of Alzheimer's Disease : Jad. PMID 31958092 DOI: 10.3233/Jad-190647  0.373
2020 Furman R, Ng SCW, Komatsu H, Axelsen PH. Quantitative Mass Spectrometric Assay of Amyloid Beta Peptide Variants with N- and C-Terminal Truncations and Modifications in Human Brain Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1206  0.312
2018 Raefsky SM, Furman R, Milne G, Pollock E, Axelsen P, Mattson MP, Shchepinov MS. Deuterated polyunsaturated fatty acids reduce brain lipid peroxidation and hippocampal amyloid β-peptide levels, without discernable behavioral effects in an APP/PS1 mutant transgenic mouse model of Alzheimer's disease. Neurobiology of Aging. 66: 165-176. PMID 29579687 DOI: 10.1016/J.Neurobiolaging.2018.02.024  0.328
2018 Eskici G, Axelsen PH. Mass Exchange and Equilibration Processes in AOT Reverse Micelles. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 29364686 DOI: 10.1021/Acs.Langmuir.7B04192  0.348
2017 Grasso G, Komatsu H, Axelsen PH. Covalent modifications of the amyloid beta peptide by hydroxynonenal: Effects on metal ion binding by monomers and insights into the fibril topology. Journal of Inorganic Biochemistry. 174: 130-136. PMID 28668508 DOI: 10.1016/J.Jinorgbio.2017.06.007  0.348
2017 Eskici G, Axelsen PH. Amyloid Beta Peptide Folding in Reverse Micelles. Journal of the American Chemical Society. PMID 28631483 DOI: 10.1021/Jacs.7B03333  0.421
2017 Komatsu H, Meurice C, Grasso G, Lippert LG, Goldman YE, Axelsen PH. Variable Binding of Thioflavin T by Amyloid Fibrils Biophysical Journal. 112: 1-8. DOI: 10.1016/J.Bpj.2016.11.1098  0.337
2016 Grasso G, Axelsen PH. Effects of Covalent Modification by 4-hydroxy-2-nonenal on the Noncovalent Oligomerization of Ubiquitin. Journal of Mass Spectrometry : Jms. PMID 27862610 DOI: 10.1002/Jms.3897  0.351
2016 Komatsu H, Axelsen PH. Amyloid Beta-Protein Fibrils from Human Alzheimer's Brain Tissue and from Mouse Models of Alzheimer's Differ in Structures Biophysical Journal. 110: 2-9. DOI: 10.1016/J.Bpj.2015.11.1214  0.314
2015 Eskici G, Axelsen P. Amyloid Fibril Nucleation In Reverse Micelles Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.389  0.385
2015 Komatsu H, Axelsen PH. Structural Variations of Amyloid β-Protein Fibrils Seeded with Extracted Fibrils from Brain Tissue of Alzheimer's Disease Model Mice Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.2880  0.323
2014 Klinger AL, Kiselar J, Ilchenko S, Komatsu H, Chance MR, Axelsen PH. A synchrotron-based hydroxyl radical footprinting analysis of amyloid fibrils and prefibrillar intermediates with residue-specific resolution. Biochemistry. 53: 7724-34. PMID 25382225 DOI: 10.1021/Bi5010409  0.382
2014 Ma J, Komatsu H, Axelsen PH. Two-Dimensional Infrared Spectroscopy and Electron Microscopy of Seeded and Non-Seeded Amyloid β Peptide Fibrils Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.3764  0.333
2013 Ma J, Komatsu H, Kim YS, Liu L, Hochstrasser RM, Axelsen PH. Intrinsic structural heterogeneity and long-term maturation of amyloid β peptide fibrils. Acs Chemical Neuroscience. 4: 1236-43. PMID 23701594 DOI: 10.1021/Cn400092V  0.367
2013 Yeung PS, Eskici G, Axelsen PH. Infrared spectroscopy of proteins in reverse micelles. Biochimica Et Biophysica Acta. 1828: 2314-8. PMID 23098833 DOI: 10.1016/J.Bbamem.2012.10.019  0.401
2013 Eskici G, Axelsen P. Simulated Amyloid Fibril Nucleation in Reverse Micelles Biophysical Journal. 104: 5-6. DOI: 10.1016/J.Bpj.2012.11.3141  0.341
2013 Komatsu H, Axelsen PH. Copper Ion Induces N-Terminal β Structure in Amyloid β Protein in Reverse Micelles Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.3134  0.362
2012 Yeung PS, Axelsen PH. The crowded environment of a reverse micelle induces the formation of β-strand seed structures for nucleating amyloid fibril formation. Journal of the American Chemical Society. 134: 6061-3. PMID 22448820 DOI: 10.1021/Ja3004478  0.354
2012 Yeung P, Komatsu H, Axelsen PH. Monomeric Amyloid β Proteins in Reverse Micelles are in Folded β Sheet Structure Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.2498  0.356
2012 Eskici G, Axelsen PH. Water Penetration into a Dry Amyloid Fibril Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1404  0.327
2012 Klinger AL, Axelsen PH. Oxidative Footprinting of Fibrillar and Prefibrillar Oligomer Forms of Amyloid Beta Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1333  0.339
2011 Haque ME, Chakraborty H, Koklic T, Komatsu H, Axelsen PH, Lentz BR. Hemagglutinin fusion peptide mutants in model membranes: structural properties, membrane physical properties, and PEG-mediated fusion. Biophysical Journal. 101: 1095-104. PMID 21889446 DOI: 10.1016/J.Bpj.2011.07.031  0.503
2011 Axelsen PH, Komatsu H, Murray IV. Oxidative stress and cell membranes in the pathogenesis of Alzheimer's disease. Physiology (Bethesda, Md.). 26: 54-69. PMID 21357903 DOI: 10.1152/Physiol.00024.2010  0.434
2011 Komatsu H, Axelsen PH. Topology of His Residues in Amyloid β Protein Fibrils Biophysical Journal. 100: 2-3. DOI: 10.1016/J.Bpj.2010.12.1320  0.467
2010 Komatsu H, Feingold-Link E, Sharp KA, Rastogi T, Axelsen PH. Intrinsic linear heterogeneity of amyloid β protein fibrils revealed by higher resolution mass-per-length determinations. The Journal of Biological Chemistry. 285: 41843-51. PMID 20940298 DOI: 10.1074/Jbc.M110.165068  0.341
2010 Axelsen PH, Murphy RC. Quantitative analysis of phospholipids containing arachidonate and docosahexaenoate chains in microdissected regions of mouse brain. Journal of Lipid Research. 51: 660-71. PMID 19767534 DOI: 10.1194/Jlr.D001750  0.33
2009 Loll PJ, Derhovanessian A, Shapovalov MV, Kaplan J, Yang L, Axelsen PH. Vancomycin forms ligand-mediated supramolecular complexes. Journal of Molecular Biology. 385: 200-11. PMID 18983853 DOI: 10.1016/J.Jmb.2008.10.049  0.307
2009 Komatsu H, Liu L, Axelsen PH. Amyloid β Proteins, Modified by a Lipid Oxidation Product, Are Nucleation Sites for Fibril Formation on Lipid Membranes Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.310  0.482
2008 Kim YS, Liu L, Axelsen PH, Hochstrasser RM. Two-dimensional infrared spectra of isotopically diluted amyloid fibrils from Abeta40. Proceedings of the National Academy of Sciences of the United States of America. 105: 7720-5. PMID 18499799 DOI: 10.1073/Pnas.0802993105  0.31
2008 Liu L, Komatsu H, Murray IV, Axelsen PH. Promotion of amyloid beta protein misfolding and fibrillogenesis by a lipid oxidation product. Journal of Molecular Biology. 377: 1236-50. PMID 18304576 DOI: 10.1016/J.Jmb.2008.01.057  0.436
2008 Axelsen PH. A chaotic pore model of polypeptide antibiotic action. Biophysical Journal. 94: 1549-50. PMID 18065456 DOI: 10.1529/Biophysj.107.124792  0.45
2007 Komatsu H, Liu L, Murray IV, Axelsen PH. A mechanistic link between oxidative stress and membrane mediated amyloidogenesis revealed by infrared spectroscopy. Biochimica Et Biophysica Acta. 1768: 1913-22. PMID 17632073 DOI: 10.1016/J.Bbamem.2007.05.026  0.429
2007 MacDonald ML, Murray IV, Axelsen PH. Mass spectrometric analysis demonstrates that BODIPY 581/591 C11 overestimates and inhibits oxidative lipid damage. Free Radical Biology & Medicine. 42: 1392-7. PMID 17395012 DOI: 10.1016/J.Freeradbiomed.2007.01.038  0.336
2007 Silva RAGD, Schneeweis LA, Krishnan SC, Zhang X, Axelsen PH, Davidson WS. The structure of apolipoprotein A-II in discoidal high density lipoproteins Journal of Biological Chemistry. 282: 9713-9721. PMID 17264082 DOI: 10.1074/Jbc.M610380200  0.321
2007 Murray IV, Liu L, Komatsu H, Uryu K, Xiao G, Lawson JA, Axelsen PH. Membrane-mediated amyloidogenesis and the promotion of oxidative lipid damage by amyloid beta proteins. The Journal of Biological Chemistry. 282: 9335-45. PMID 17255094 DOI: 10.1074/Jbc.M608589200  0.458
2006 Londergan CH, Wang J, Axelsen PH, Hochstrasser RM. Two-dimensional infrared spectroscopy displays signatures of structural ordering in peptide aggregates. Biophysical Journal. 90: 4672-85. PMID 16565049 DOI: 10.1529/Biophysj.105.075812  0.44
2005 Haque ME, Koppaka V, Axelsen PH, Lentz BR. Properties and structures of the influenza and HIV fusion peptides on lipid membranes: implications for a role in fusion. Biophysical Journal. 89: 3183-94. PMID 16183890 DOI: 10.1529/Biophysj.105.063032  0.465
2005 Murray IV, Sindoni ME, Axelsen PH. Promotion of oxidative lipid membrane damage by amyloid beta proteins. Biochemistry. 44: 12606-13. PMID 16156673 DOI: 10.1021/Bi050926P  0.394
2005 Paul C, Axelsen PH. beta Sheet structure in amyloid beta fibrils and vibrational dipolar coupling. Journal of the American Chemical Society. 127: 5754-5. PMID 15839650 DOI: 10.1021/Ja042569W  0.33
2004 Jusuf S, Axelsen PH. Synchronized conformational fluctuations and binding site desolvation during molecular recognition. Biochemistry. 43: 15446-52. PMID 15581356 DOI: 10.1021/Bi048357T  0.319
2004 Paul C, Wang J, Wimley WC, Hochstrasser RM, Axelsen PH. Vibrational coupling, isotopic editing, and beta-sheet structure in a membrane-bound polypeptide. Journal of the American Chemical Society. 126: 5843-50. PMID 15125676 DOI: 10.1021/Ja038869F  0.438
2004 Murray IV, Paul C, Axelsen PH. P4-243 Accelerated misfolding of amyloid beta protein by oxidized lipids Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81801-3  0.34
2003 Koppaka V, Paul C, Murray IV, Axelsen PH. Early synergy between Abeta42 and oxidatively damaged membranes in promoting amyloid fibril formation by Abeta40. The Journal of Biological Chemistry. 278: 36277-84. PMID 12821671 DOI: 10.1074/Jbc.M301334200  0.436
2003 Hong RW, Shchepetov M, Weiser JN, Axelsen PH. Transcriptional profile of the Escherichia coli response to the antimicrobial insect peptide cecropin A. Antimicrobial Agents and Chemotherapy. 47: 1-6. PMID 12499161 DOI: 10.1128/Aac.47.1.1-6.2003  0.394
2001 Kaplan J, Korty BD, Axelsen PH, Loll PJ. The role of sugar residues in molecular recognition by vancomycin Journal of Medicinal Chemistry. 44: 1837-1840. PMID 11356118 DOI: 10.1021/Jm0005306  0.312
2001 Pender BA, Wu X, Axelsen PH, Cooperman BS. Toward a rational design of peptide inhibitors of ribonucleotide reductase: structure-function and modeling studies. Journal of Medicinal Chemistry. 44: 36-46. PMID 11141086 DOI: 10.1021/Jm000335R  0.304
2001 Koppaka V, Axelsen PH. Evanescent electric field amplitudes in thin lipid films for internal reflection infrared spectroscopy Langmuir. 17: 6309-6316. DOI: 10.1021/La010731S  0.336
2000 Silvestro L, Axelsen PH. Membrane-Induced Folding of Cecropin A Biophysical Journal. 79: 1465-1477. PMID 10969008 DOI: 10.1016/S0006-3495(00)76398-3  0.79
2000 Koppaka V, Axelsen PH. Accelerated accumulation of amyloid β proteins on oxidatively damaged lipid membranes Biochemistry. 39: 10011-10016. PMID 10933822 DOI: 10.1021/Bi000619D  0.454
2000 Weinstein EA, Li H, Lawson JA, Rokach J, FitzGerald GA, Axelsen PH. Prothrombinase acceleration by oxidatively damaged phospholipids. The Journal of Biological Chemistry. 275: 22925-30. PMID 10801844 DOI: 10.1074/Jbc.M002438200  0.411
2000 Silvestro L, Weiser JN, Axelsen PH. Antibacterial and antimembrane activities of cecropin A in Escherichia coli Antimicrobial Agents and Chemotherapy. 44: 602-607. PMID 10681325 DOI: 10.1128/Aac.44.3.602-607.2000  0.763
2000 Koppaka V, Weinstein E, Axelsen PH. Accelerated β amyloid nucleation by oxidatively damaged lipid membranes Neurobiology of Aging. 21: 9. DOI: 10.1016/S0197-4580(00)82717-7  0.435
1999 Koppaka V, Axelsen PH. Lipoprotein A-I structure Trends in Cardiovascular Medicine. 9: 192-195. PMID 10881750 DOI: 10.1016/S1050-1738(00)00024-4  0.377
1999 Koppaka V, Silvestro L, Engler JA, Brouillette CG, Axelsen PH. The structure of human lipoprotein A-I. Evidence for the "belt" model. The Journal of Biological Chemistry. 274: 14541-4. PMID 10329643 DOI: 10.1074/Jbc.274.21.14541  0.755
1999 Silvestro L, Axelsen PH. Fourier transform infrared linked analysis of conformational changes in annexin V upon membrane binding. Biochemistry. 38: 113-121. PMID 9890889 DOI: 10.1021/Bi981289O  0.774
1998 Silvestro L, Axelsen PH. Infrared spectroscopy of supported lipid monolayer, bilayer, and multibilayer membranes Chemistry and Physics of Lipids. 96: 69-80. PMID 9871983 DOI: 10.1016/S0009-3084(98)00081-4  0.787
1998 Loll PJ, Miller R, Weeks CM, Axelsen PH. A ligand-mediated dimerization mode for vancomycin Chemistry & Biology. 5: 293-298. PMID 9578636 DOI: 10.1016/S1074-5521(98)90622-6  0.335
1998 Wimley WC, Hristova K, Ladokhin AS, Silvestro L, Axelsen PH, White SH. Folding of β-sheet membrane proteins: A hydrophobic hexapeptide model Journal of Molecular Biology. 277: 1091-1110. PMID 9571025 DOI: 10.1006/Jmbi.1998.1640  0.784
1997 Li D, Sreenivasan U, Juranic N, Macura S, Puga FJ, Frohnert PM, Axelsen PH. Simulated dipeptide recognition by vancomycin. Journal of Molecular Recognition : Jmr. 10: 73-87. PMID 9376130 DOI: 10.1002/(Sici)1099-1352(199703/04)10:2<73::Aid-Jmr347>3.0.Co;2-1  0.311
1997 Silvestro L, Gupta K, Weiser JN, Axelsen PH. The concentration-dependent membrane activity of cecropin A Biochemistry. 36: 11452-11460. PMID 9298965 DOI: 10.1021/Bi9630826  0.775
1996 Citra MJ, Axelsen PH. Determination of molecular order in supported lipid membranes by internal reflection Fourier transform infrared spectroscopy Biophysical Journal. 71: 1796-1805. PMID 8889156 DOI: 10.1016/S0006-3495(96)79380-3  0.446
1995 Axelsen PH, Kaufman BK, Mcelhaney RN, Lewis RNAH. The infrared dichroism of transmembrane helical polypeptides Biophysical Journal. 69: 2770-2781. PMID 8599683 DOI: 10.1016/S0006-3495(95)80150-5  0.419
1995 Axelsen PH, Braddock WD, Brockman HL, Jones CM, Dluhy RA, Kaufman BK, Puga FJ. Use of Internal Reflectance Infrared Spectroscopy for thein SituStudy of Supported Lipid Monolayers Applied Spectroscopy. 49: 526-531. DOI: 10.1366/0003702953964273  0.375
Low-probability matches (unlikely to be authored by this person)
1989 Axelsen PH, Prendergast FG. Molecular dynamics of tryptophan in ribonuclease-T1. II. Correlations with fluorescence. Biophysical Journal. 56: 43-66. PMID 2502198 DOI: 10.1016/S0006-3495(89)82651-7  0.298
2011 Murphy RC, Axelsen PH. Mass spectrometric analysis of long-chain lipids. Mass Spectrometry Reviews. 30: 579-99. PMID 21656842 DOI: 10.1002/Mas.20284  0.296
1996 Axelsen PH, Citra MJ. Orientational order determination by internal reflection infrared spectroscopy. Progress in Biophysics & Molecular Biology. 66: 227-253. PMID 9284452 DOI: 10.1016/S0079-6107(97)00007-2  0.295
2009 Kim YS, Liu L, Axelsen PH, Hochstrasser RM. 2D IR provides evidence for mobile water molecules in beta-amyloid fibrils. Proceedings of the National Academy of Sciences of the United States of America. 106: 17751-6. PMID 19815514 DOI: 10.1073/Pnas.0909888106  0.292
1991 Axelsen PH, Bajzer Z, Prendergast FG, Cottam PF, Ho C. Resolution of fluorescence intensity decays of the two tryptophan residues in glutamine-binding protein from Escherichia coli using single tryptophan mutants Biophysical Journal. 60: 650-659. PMID 1932553 DOI: 10.1016/S0006-3495(91)82094-X  0.29
2004 Schneeweis LA, Koppaka V, Axelsen PH. P2-299 Comparative structural analysis of apolipoprotein E isoforms and their interaction with amyloid-beta 42 Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81044-3  0.288
2016 Furman R, Murray IV, Schall HE, Liu Q, Ghiwot Y, Axelsen PH. The Fate of Uniformly Radiolabeled Arachidonic Acid in Alzheimer Mouse Brain: Plaque-associated Oxidative Degradation. Acs Chemical Neuroscience. PMID 26800372 DOI: 10.1021/Acschemneuro.5B00316  0.288
2012 Falvo C, Zhuang W, Kim YS, Axelsen PH, Hochstrasser RM, Mukamel S. Frequency distribution of the amide-I vibration sorted by residues in amyloid fibrils revealed by 2D-IR measurements and simulations. The Journal of Physical Chemistry. B. 116: 3322-30. PMID 22338639 DOI: 10.1021/Jp2096423  0.287
2019 Lin YC, Komatsu H, Ma J, Axelsen PH, Fakhraai Z. Identifying Polymorphs of Amyloid-β (1-40) Fibrils Using High-Resolution Atomic Force Microscopy. The Journal of Physical Chemistry. B. PMID 31714085 DOI: 10.1021/Acs.Jpcb.9B07854  0.287
1994 Axelsen PH, Harel M, Silman I, Sussman JL. Structure and dynamics of the active site gorge of acetylcholinesterase: Synergistic use of molecular dynamics simulation and X-ray crystallography Protein Science. 3: 188-197. PMID 8003956 DOI: 10.1002/Pro.5560030204  0.286
2017 Eskici G, Axelsen P. Microsecond Simulations of Amyloid Beta Fibril Nucleation in Reverse Micelles Biophysical Journal. 112: 528. DOI: 10.1016/J.Bpj.2016.11.2859  0.282
1993 Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proceedings of the National Academy of Sciences of the United States of America. 90: 9031-5. PMID 8415649 DOI: 10.1073/Pnas.90.19.9031  0.282
1999 Loll PJ, Kaplan J, Selinsky BS, Axelsen PH. Vancomycin binding to low-affinity ligands: Delineating a minimum set of interactions necessary for high-affinity binding Journal of Medicinal Chemistry. 42: 4714-4719. PMID 10579833 DOI: 10.1021/Jm990361T  0.282
2003 Jusuf S, Loll PJ, Axelsen PH. Configurational entropy and cooperativity between ligand binding and dimerization in glycopeptide antibiotics. Journal of the American Chemical Society. 125: 3988-94. PMID 12656635 DOI: 10.1021/Ja027780R  0.28
2014 Eskici G, Axelsen P. Molecular Modeling and Simulations of Reverse Micelles Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.1698  0.279
2016 Axelsen PH, Murphy RC, Igarashi M, Rapoport SI. Increased ω6-Containing Phospholipids and Primary ω6 Oxidation Products in the Brain Tissue of Rats on an ω3-Deficient Diet. Plos One. 11: e0164326. PMID 27788153 DOI: 10.1371/Journal.Pone.0164326  0.274
2018 Mourelatos HA, Komatsu H, Furman R, Grasso G, Axelsen PH. Amyloid Beta Proteins Modified by PUFA Oxidation Products in Alzheimer's Disease Brain Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.1277  0.274
2023 Kikuchi H, Takahashi M, Komatsu H, Axelsen PH. Post-Translational Chemical Modifications of Amyloid-β Peptides by 4-Hydroxy-2-Nonenal. Journal of Alzheimer's Disease : Jad. PMID 36776059 DOI: 10.3233/JAD-220940  0.272
2016 Eskici G, Axelsen PH. The Size of a Reverse Micelle Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.3056  0.271
2005 Schneeweis LA, Koppaka V, Lund-Katz S, Phillips MC, Axelsen PH. Structural analysis of lipoprotein E particles. Biochemistry. 44: 12525-34. PMID 16156664 DOI: 10.1021/Bi050872J  0.27
1997 Loll PJ, Bevivino AE, Korty BD, Axelsen PH. Simultaneous recognition of a carboxylate-containing ligand and an intramolecular surrogate ligand in the crystal structure of an asymmetric vancomycin dimer Journal of the American Chemical Society. 119: 1516-1522. DOI: 10.1021/Ja963566P  0.267
2006 Cegelski L, Steuber D, Mehta AK, Kulp DW, Axelsen PH, Schaefer J. Conformational and quantitative characterization of oritavancin-peptidoglycan complexes in whole cells of Staphylococcus aureus by in vivo 13C and 15N labeling. Journal of Molecular Biology. 357: 1253-62. PMID 16483598 DOI: 10.1016/J.Jmb.2006.01.040  0.266
2015 Furman R, Murray IV, Schall HE, Liu J, Ghiwot Y, Axelsen PH. P3-030: Oxidative degradation of arachidonic acid is increased in the vicinity of amyloid plaques in Alzheimer's disease Alzheimer's & Dementia. 11: P630-P631. DOI: 10.1016/J.Jalz.2015.06.896  0.266
2002 Jusuf S, Loll PJ, Axelsen PH. The role of configurational entropy in biochemical cooperativity. Journal of the American Chemical Society. 124: 3490-1. PMID 11929222 DOI: 10.1021/Ja017259H  0.263
1994 Axelsen PH. Acetylcholine Recognition by an Aromatic Host: the Role of an All‐Hydrogen Topology in Simulations of the Cation‐π Interaction Israel Journal of Chemistry. 34: 159-163. DOI: 10.1002/Ijch.199400021  0.261
1998 Axelsen PH, Li D. A rational strategy for enhancing the affinity of vancomycin towards depsipeptide ligands Bioorganic & Medicinal Chemistry. 6: 877-881. PMID 9730223 DOI: 10.1016/S0968-0896(98)00019-4  0.261
1993 Ripoll DR, Faerman CH, Axelsen PH, Silman I, Sussman JL. An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase. Proceedings of the National Academy of Sciences of the United States of America. 90: 5128-32. PMID 8506359 DOI: 10.1073/Pnas.90.11.5128  0.26
2000 Loll PJ, Axelsen PH. The structural biology of molecular recognition by vancomycin Annual Review of Biophysics and Biomolecular Structure. 29: 265-289. PMID 10940250 DOI: 10.1146/Annurev.Biophys.29.1.265  0.259
1991 Axelsen PH, Gratton E, Prendergast FG. Experimentally verifying molecular dynamics simulations through fluorescence anisotropy measurements Biochemistry. 30: 1173-1179. PMID 1991096 DOI: 10.1021/Bi00219A002  0.257
2005 Greenbaum EA, Graves CL, Mishizen-Eberz AJ, Lupoli MA, Lynch DR, Englander SW, Axelsen PH, Giasson BI. The E46K mutation in alpha-synuclein increases amyloid fibril formation. The Journal of Biological Chemistry. 280: 7800-7. PMID 15632170 DOI: 10.1074/Jbc.M411638200  0.256
1992 Sreenivasan U, Axelsen PH. Buried water in homologous serine proteases. Biochemistry. 31: 12785-12791. PMID 1334431 DOI: 10.1021/Bi00166A011  0.256
2018 Furman R, Lee JV, Axelsen PH. Analysis of Eicosanoid Oxidation Products in Alzheimer Brain by LC-MS with Uniformly 13C-Labeled Internal Standards. Free Radical Biology & Medicine. PMID 29476920 DOI: 10.1016/J.Freeradbiomed.2018.02.019  0.255
1998 Shangguan T, Siegel DP, Lear JD, Axelsen PH, Alford D, Bentz J. Morphological Changes and Fusogenic Activity of Influenza Virus Hemagglutinin Biophysical Journal. 74: 54-62. PMID 9449309 DOI: 10.1016/S0006-3495(98)77766-5  0.252
2016 Eskici G, Axelsen PH. The Size of AOT Reverse Micelles. The Journal of Physical Chemistry. B. PMID 27739299 DOI: 10.1021/Acs.Jpcb.6B06420  0.248
1998 Narasimhulu S, Havran LM, Axelsen PH, Winkler JD. Interactions of substrate and product with cytochrome P450: P4502B4 versus P450cam. Archives of Biochemistry and Biophysics. 353: 228-38. PMID 9606957 DOI: 10.1006/Abbi.1998.0650  0.246
1996 Winkler JD, Axelsen PH. A model for the taxol (paclitaxel)/epothilone pharmacophore Bioorganic and Medicinal Chemistry Letters. 6: 2963-2966. DOI: 10.1016/S0960-894X(96)00555-0  0.245
1988 Axelsen PH, Haydock C, Prendergast FG. Molecular dynamics of tryptophan in ribonuclease-T1. I. Simulation strategies and fluorescence anisotropy decay. Biophysical Journal. 54: 249-258. PMID 3145038 DOI: 10.1016/S0006-3495(88)82954-0  0.243
2016 Lin Y, Komatsu H, Ma J, Axelsen PH, Fakhraai Z. Quantitative analysis of amyloid polymorphism using height histograms to correct for tip convolution effects in atomic force microscopy imaging Rsc Advances. 6: 114286-114295. DOI: 10.1039/C6Ra24031C  0.243
2019 Palmer NJ, Eskici G, Axelsen PH. Non-equilibrium Mass Exchange in AOT Reverse Micelles. The Journal of Physical Chemistry. B. PMID 31793793 DOI: 10.1021/Acs.Jpcb.9B08511  0.242
1994 Silman I, Harel M, Axelsen P, Raves M, Sussman JL. Three-dimensional structures of acetylcholinesterase and of its complexes with anticholinesterase agents Biochemical Society Transactions. 22: 745-749. PMID 7821677 DOI: 10.1042/Bst0220745  0.232
2019 Furman R, Axelsen PH. The effects of omega-3 fatty acid deficiency during development on oxidative fatty acid degradation during maturity in a mouse model of Alzheimer's disease. Neurobiology of Aging. 79: 66-74. PMID 31029017 DOI: 10.1016/J.Neurobiolaging.2019.03.001  0.227
2012 Eskici G, Axelsen PH. Copper and oxidative stress in the pathogenesis of Alzheimer's disease. Biochemistry. 51: 6289-311. PMID 22708607 DOI: 10.1021/Bi3006169  0.226
2003 Murray IV, Giasson BI, Quinn SM, Koppaka V, Axelsen PH, Ischiropoulos H, Trojanowski JQ, Lee VM. Role of alpha-synuclein carboxy-terminus on fibril formation in vitro. Biochemistry. 42: 8530-40. PMID 12859200 DOI: 10.1021/Bi027363R  0.225
2020 Song P, Kuryatov A, Axelsen PH. Biosynthesis of uniformly carbon isotope-labeled docosahexaenoic acid in Crypthecodinium cohnii. Amb Express. 10: 45. PMID 32162160 DOI: 10.1186/S13568-020-00981-0  0.224
2020 Song P, Kuryatov A, Axelsen PH. A new synthetic medium for the optimization of docosahexaenoic acid production in Crypthecodinium cohnii. Plos One. 15: e0229556. PMID 32196504 DOI: 10.1371/Journal.Pone.0229556  0.21
2001 Winkler JD, Piatnitski EL, Mehlmann J, Kasparec J, Axelsen PH. Design and Synthesis of Foldamers Based on an Anthracene Diels-Alder Adduct We thank Professor Samuel H. Gellman (University of Wisconsin) and Professors William F. DeGrado and Stanley J. Opella (University of Pennsylvania) for valuable discussions. We also thank Ms. Lori Krim and Mr. Daniel Macks for their experimental and computational contributions to the early stages of this work. Generous financial support from Boehringer-Ingelheim and Alfred P. Bader (J.K.: Alfred E. Bader Fellow, 1996-1998) is gratefully acknowledged. Angewandte Chemie (International Ed. in English). 40: 743-745. PMID 11241609 DOI: 10.1002/1521-3773(20010216)40:4<743::Aid-Anie7430>3.0.Co;2-0  0.207
2016 Lee JV, Furman R, Axelsen PH. Biosynthesis of uniformly labeled (13)C- and (14)C-arachidonic acid in Mortierella alpina. Bioresource Technology. 227: 142-146. PMID 28013130 DOI: 10.1016/J.Biortech.2016.12.050  0.204
1999 Winkler JD, Holland JM, Kasparec J, Axelsen PH. Design and synthesis of constrained epothilone analogs: The efficient synthesis of eleven-membered rings by olefin metathesis Tetrahedron. 55: 8199-8214. DOI: 10.1016/S0040-4020(99)00301-4  0.193
1998 Axelsen PH, Li D. Improved convergence in dual-topology free energy calculations through use of harmonic restraints Journal of Computational Chemistry. 19: 1278-1283. DOI: 10.1002/(Sici)1096-987X(199808)19:11<1278::Aid-Jcc7>3.0.Co;2-H  0.187
1996 Poland GA, Axelsen PH, Felz MW. Hepatitis A and B Infections Among Expatriates in Papua New Guinea: A Missed Opportunity for Immunization Journal of Travel Medicine. 3: 209-213. PMID 9815458 DOI: 10.1111/J.1708-8305.1996.Tb00748.X  0.185
1984 Hall S, Axelsen PH, Larson DE, Bunch TW. Systemic Lupus Erythematosus Developing in Patients with Primary Biliary Cirrhosis Annals of Internal Medicine. 100: 388-389. PMID 6696359 DOI: 10.7326/0003-4819-100-3-388  0.181
2022 Ng SCW, Furman R, Axelsen PH, Shchepinov MS. Free Radical Chain Reactions and Polyunsaturated Fatty Acids in Brain Lipids. Acs Omega. 7: 25337-25345. PMID 35910174 DOI: 10.1021/acsomega.2c02285  0.181
1999 Axelsen PH. Zoonoses: Biology, Clinical Practice, and Public Health Control Jama. 281. DOI: 10.1001/Jama.281.7.669-A  0.174
2020 Axelsen PH. Immunized by irony. Vaccine. PMID 32829978 DOI: 10.1016/J.Vaccine.2020.08.027  0.158
2022 Liu Y, Bell BA, Song Y, Zhang K, Anderson B, Axelsen PH, Bohannan W, Agbaga MP, Park HG, James G, Brenna JT, Schmidt K, Dunaief JL, Shchepinov MS. Deuterated docosahexaenoic acid protects against oxidative stress and geographic atrophy-like retinal degeneration in a mouse model with iron overload. Aging Cell. e13579. PMID 35257475 DOI: 10.1111/acel.13579  0.095
2024 Zaleski MH, Omo-Lamai S, Nong J, Chase LS, Myerson JW, Glassman PM, Lee F, Reyes-Esteves S, Wang Z, Patel M, Peshkova AD, Komatsu H, Axelsen PH, Muzykantov VR, Marcos-Contreras OA, et al. Nanocarriers' repartitioning of drugs between blood subcompartments as a mechanism of improving pharmacokinetics, safety, and efficacy. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 39103056 DOI: 10.1016/j.jconrel.2024.07.070  0.082
2002 Axelsen PH. Should family members be present during cardiopulmonary resuscitation? The New England Journal of Medicine. 347: 450-2; author reply . PMID 12167695 DOI: 10.1056/NEJM200208083470618  0.01
2021 Axelsen PH, Poland GA. Vaccines, masks, distancing and credibility: An urgent warning for pandemic management. Vaccine. PMID 33536137 DOI: 10.1016/j.vaccine.2021.01.052  0.01
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