| Year |
Citation |
Score |
| 2019 |
Mensa-Wilmot K, Hoffman B, Wiedeman J, Sullenberger C, Sharma A. Kinetoplast Division Factors in a Trypanosome. Trends in Parasitology. PMID 30638954 DOI: 10.1016/J.Pt.2018.11.002 |
0.34 |
|
| 2018 |
Bachovchin KA, Sharma A, Bag S, Klug DM, Schneider KM, Singh B, Jalani HB, Buskes M, Mehta N, Tanghe S, Momper JD, Sciotti RJ, Rodriguez A, Mensa-Wilmot K, Pollastri MP, et al. Improvement of Aqueous Solubility of Lapatinib-derived Analogs: Identification of a Quinolinimine as a Lead for Human African Trypanosomiasis Drug Development. Journal of Medicinal Chemistry. PMID 30565932 DOI: 10.1021/Acs.Jmedchem.8B01365 |
0.301 |
|
| 2017 |
Devine W, Thomas SM, Erath J, Bachovchin KA, Lee PJ, Leed SE, Rodriguez A, Sciotti RJ, Mensa-Wilmot K, Pollastri MP. Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites. Acs Medicinal Chemistry Letters. 8: 350-354. PMID 28337329 DOI: 10.1021/Acsmedchemlett.7B00011 |
0.314 |
|
| 2016 |
Guyett PJ, Behera R, Ogata Y, Pollastri M, Mensa-Wilmot K. Novel Effects of Lapatinib Revealed in the African Trypanosome using Hypothesis-Generating Proteomics and Chemical Biology Strategies. Antimicrobial Agents and Chemotherapy. PMID 27872081 DOI: 10.1128/Aac.01865-16 |
0.393 |
|
| 2015 |
Woodring JL, Patel G, Erath J, Behera R, Lee PJ, Leed SE, Rodriguez A, Sciotti RJ, Mensa-Wilmot K, Pollastri MP. EVALUATION OF AROMATIC 6-SUBSTITUTED THIENOPYRIMIDINES AS SCAFFOLDS AGAINST PARASITES THAT CAUSE TRYPANOSOMIASIS, LEISHMANIASIS, AND MALARIA. Medchemcomm. 6: 339-346. PMID 25685309 DOI: 10.1039/C4Md00441H |
0.32 |
|
| 2013 |
Katiyar S, Kufareva I, Behera R, Thomas SM, Ogata Y, Pollastri M, Abagyan R, Mensa-Wilmot K. Lapatinib-binding protein kinases in the African trypanosome: identification of cellular targets for kinase-directed chemical scaffolds. Plos One. 8: e56150. PMID 23437089 DOI: 10.1371/Journal.Pone.0056150 |
0.313 |
|
| 2010 |
Subramanya S, Armah DA, Mensa-Wilmot K. Trypanosoma brucei: reduction of GPI-phospholipase C protein during differentiation is dependent on replication of newly transformed cells. Experimental Parasitology. 125: 222-9. PMID 20109448 DOI: 10.1016/J.Exppara.2010.01.014 |
0.317 |
|
| 2010 |
Subramanya S, Mensa-Wilmot K. Diacylglycerol-stimulated endocytosis of transferrin in trypanosomatids is dependent on tyrosine kinase activity. Plos One. 5: e8538. PMID 20049089 DOI: 10.1371/Journal.Pone.0008538 |
0.368 |
|
| 2010 |
Duffy J, Patham B, Mensa-Wilmot K. Discovery of functional motifs in h-regions of trypanosome signal sequences. The Biochemical Journal. 426: 135-45. PMID 20017734 DOI: 10.1042/Bj20091277 |
0.397 |
|
| 2009 |
Patham B, Duffy J, Lane A, Davis RC, Wipf P, Fewell SW, Brodsky JL, Mensa-Wilmot K. Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities. The Biochemical Journal. 419: 507-17. PMID 19196237 DOI: 10.1042/Bj20081787 |
0.373 |
|
| 2009 |
Subramanya S, Hardin CF, Steverding D, Mensa-Wilmot K. Glycosylphosphatidylinositol-specific phospholipase C regulates transferrin endocytosis in the African trypanosome. The Biochemical Journal. 417: 685-94. PMID 18785878 DOI: 10.1042/Bj20080167 |
0.38 |
|
| 2006 |
Stanton JD, Mensa-Wilmot K. AUG-proximal nucleotides regulate protein synthesis in Leishmania tropica. Molecular Microbiology. 61: 691-703. PMID 16787450 DOI: 10.1111/J.1365-2958.2006.05228.X |
0.42 |
|
| 2006 |
Subramanya S, Mensa-Wilmot K. Regulated cleavage of intracellular glycosylphosphatidylinositol in a trypanosome. Peroxisome-to-endoplasmic reticulum translocation of a phospholipase C. The Febs Journal. 273: 2110-26. PMID 16649989 DOI: 10.1111/J.1742-4658.2006.05225.X |
0.388 |
|
| 2005 |
Zheng Z, Tweten RK, Mensa-Wilmot K. Intracellular glycosylphosphatidylinositols accumulate on endosomes: toxicity of alpha-toxin to Leishmania major. Eukaryotic Cell. 4: 556-66. PMID 15755918 DOI: 10.1128/Ec.4.3.556-566.2005 |
0.304 |
|
| 2004 |
Zheng Z, Butler KD, Tweten RK, Mensa-Wilmot K. Endosomes, glycosomes, and glycosylphosphatidylinositol catabolism in Leishmania major. The Journal of Biological Chemistry. 279: 42106-13. PMID 15254033 DOI: 10.1074/Jbc.M403780200 |
0.412 |
|
| 2002 |
Stanton JD, Rashid MB, Mensa-Wilmot K. Cysteine-less glycosylphosphatidylinositol-specific phospholipase C is inhibited competitively by a thiol reagent: evidence for glyco-mimicry by p-chloromercuriphenylsulphonate. The Biochemical Journal. 366: 281-8. PMID 12010122 DOI: 10.1042/Bj20020367 |
0.344 |
|
| 2000 |
Armah DA, Mensa-Wilmot K. Tetramerization of glycosylphosphatidylinositol-specific phospholipase C from Trypanosoma brucei. Journal of Biological Chemistry. 275: 19334-19342. PMID 10764777 DOI: 10.1074/Jbc.M001798200 |
0.347 |
|
| 2000 |
Rashid MB, Mensa-Wilmot K. Novel kanamycin/neomycin phosphotransferase cassette increases transformation efficiency in E. coli. Biotechniques. 28: 90-94. PMID 10649776 DOI: 10.2144/00281St03 |
0.302 |
|
| 1999 |
Rashid MB, Russell M, Mensa-Wilmot K. Roles of Gln81 and Cys80 in catalysis by glycosylphosphatidylinositol-phospholipase C from Trypanosoma brucei Febs Journal. 264: 914-920. PMID 10491140 DOI: 10.1046/J.1432-1327.1999.00690.X |
0.346 |
|
| 1999 |
Mensa-Wilmot K, Garg N, McGwire BS, Lu HG, Zhong L, Armah DA, LeBowitz JH, Chang KP. Roles of free GPIs in amastigotes of Leishmania. Molecular and Biochemical Parasitology. 99: 103-16. PMID 10215028 DOI: 10.1016/S0166-6851(99)00003-1 |
0.334 |
|
| 1999 |
Armah DA, Mensa-Wilmot K. Protein S-Myristoylation inLeishmaniaRevealed with a Heterologous Reporter☆ Biochemical and Biophysical Research Communications. 256: 569-572. PMID 10080938 DOI: 10.1006/Bbrc.1999.0376 |
0.372 |
|
| 1999 |
Armah DA, Mensa-Wilmot K. S-myristoylation of a glycosylphosphatidylinositol-specific phospholipase C in Trypanosoma brucei. Journal of Biological Chemistry. 274: 5931-5938. PMID 10026218 DOI: 10.1074/Jbc.274.9.5931 |
0.364 |
|
| 1998 |
Teilhet M, Rashid MB, Hawk A, Al-Qahtani A, Mensa-Wilmot K. Effect of short 5' UTRs on protein synthesis in two biological kingdoms. Gene. 222: 91-97. PMID 9813258 DOI: 10.1016/S0378-1119(98)00470-3 |
0.581 |
|
| 1998 |
Al-Qahtani A, Teilhet M, Mensa-Wilmot K. Species-specificity in endoplasmic reticulum signal peptide utilization revealed by proteins from Trypanosoma brucei and Leishmania. Biochemical Journal. 331: 521-529. PMID 9531493 DOI: 10.1042/Bj3310521 |
0.572 |
|
| 1997 |
Morris JC, Mensa-Wilmot K. Role of 2,6-dideoxy-2,6-diaminoglucose in activation of a eukaryotic phospholipase C by aminoglycoside antibiotics Journal of Biological Chemistry. 272: 29554-29559. PMID 9368017 DOI: 10.1074/Jbc.272.47.29554 |
0.322 |
|
| 1997 |
Garg N, Tarleton RL, Mensa-Wilmot K. Proteins with glycosylphosphatidylinositol (GPI) signal sequences have divergent fates during a GPI deficiency. GPIs are essential for nuclear division in Trypanosoma cruzi. The Journal of Biological Chemistry. 272: 12482-91. PMID 9139697 DOI: 10.1074/Jbc.272.19.12482 |
0.421 |
|
| 1996 |
Morris JC, Ping-Sheng L, Zhai HX, Shen TY, Mensa-Wilmot K. Phosphatidylinositol phospholipase C is activated allosterically by the aminoglycoside G418. 2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecylphosphonate and its analogs inhibit glycosylphosphatidylinositol phospholipase C. The Journal of Biological Chemistry. 271: 15468-77. PMID 8663028 DOI: 10.1074/Jbc.271.26.15468 |
0.307 |
|
| 1996 |
Al-Qahtani A, Mensa-Wilmot K. A 5′ Untranslated Region Which Directs Accurate and Robust Translation By Prokaryotic and Mammalian Ribosomes Nucleic Acids Research. 24: 1173-1174. PMID 8604355 DOI: 10.1093/Nar/24.6.1173 |
0.345 |
|
| 1995 |
Mensa-Wilmot K, Morris JC, al-Qahtani A, Englund PT. Purification and use of recombinant glycosylphosphatidylinositol-phospholipase C. Methods in Enzymology. 250: 641-55. PMID 7651183 DOI: 10.1016/0076-6879(95)50102-9 |
0.473 |
|
| 1995 |
Zhai H, Lei P, Morris JC, Mensa-Wilmot K, Shen TY. Synthesis of 2-deoxy-2-fluorinated inositol-1-0-dodecylphosphonates as inhibitors of glycosyl phosphatidylinositol phospholipase C Tetrahedron Letters. 36: 7403-7406. DOI: 10.1016/0040-4039(95)01579-5 |
0.309 |
|
| 1994 |
Mensa-Wilmot K, LeBowitz JH, Chang KP, Al-Qahtani A, McGwire BS, Tucker S, Morris JC. A glycosylphosphatidylinositol (GPI)-negative phenotype produced in Leishmania major by GPI phospholipase C from Trypanosoma brucei: Topography of two GPI pathways Journal of Cell Biology. 124: 935-947. PMID 8132715 DOI: 10.1083/Jcb.124.6.935 |
0.406 |
|
| 1992 |
Mensa-Wilmot K, Englund PT. Non-fusion proteins expressed in E. coli: detection by alpha-complementation (blue/white selection). Nucleic Acids Research. 20: 143. PMID 1738595 DOI: 10.1093/Nar/20.1.143 |
0.519 |
|
| 1992 |
Mensa-Wilmot K, Englund PT. Glycosyl phosphatidylinositol-specific phospholipase C of Trypanosoma brucei: expression in Escherichia coli. Molecular and Biochemical Parasitology. 56: 311-21. PMID 1362451 DOI: 10.1016/0166-6851(92)90180-R |
0.533 |
|
| 1990 |
Mensa-Wilmot K, Hereld D, Englund PT. Genomic organization, chromosomal localization, and developmentally regulated expression of the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma brucei. Molecular and Cellular Biology. 10: 720-6. PMID 1688997 DOI: 10.1128/Mcb.10.2.720 |
0.535 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 1997 |
Garg N, Postan M, Mensa-Wilmot K, Tarleton RL. Glycosylphosphatidylinositols are required for the development of Trypanosoma cruzi amastigotes. Infection and Immunity. 65: 4055-60. PMID 9317007 DOI: 10.1128/Iai.65.10.4055-4060.1997 |
0.298 |
|
| 2015 |
Devine W, Woodring JL, Swaminathan U, Amata E, Patel G, Erath J, Roncal NE, Lee PJ, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Pollastri MP. Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery. Journal of Medicinal Chemistry. 58: 5522-37. PMID 26087257 DOI: 10.1021/Acs.Jmedchem.5B00515 |
0.298 |
|
| 2020 |
Lepovitz LT, Meis AR, Thomas SM, Wiedeman J, Pham A, Mensa-Wilmot K, Martin SF. Design, Synthesis, and Evaluation of Novel Anti-Trypanosomal Compounds. Tetrahedron. 76. PMID 32382196 DOI: 10.1016/J.Tet.2020.131086 |
0.297 |
|
| 2017 |
Woodring JL, Bachovchin KA, Brady KG, Gallerstein MF, Erath J, Tanghe S, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Pollastri MP. Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation. European Journal of Medicinal Chemistry. 141: 446-459. PMID 29049963 DOI: 10.1016/J.Ejmech.2017.10.007 |
0.296 |
|
| 1986 |
Dodson M, Echols H, Wickner S, Alfano C, Mensa-Wilmot K, Gomes B, LeBowitz J, Roberts JD, McMacken R. Specialized nucleoprotein structures at the origin of replication of bacteriophage λ: Localized unwinding of duplex DNA by a six-protein reaction Proceedings of the National Academy of Sciences of the United States of America. 83: 7638-7642. PMID 3020552 DOI: 10.1073/Pnas.83.20.7638 |
0.296 |
|
| 2014 |
Behera R, Thomas SM, Mensa-Wilmot K. New chemical scaffolds for human african trypanosomiasis lead discovery from a screen of tyrosine kinase inhibitor drugs. Antimicrobial Agents and Chemotherapy. 58: 2202-10. PMID 24468788 DOI: 10.1128/Aac.01691-13 |
0.295 |
|
| 2017 |
Thomas SM, Purmal A, Pollastri M, Mensa-Wilmot K. Erratum: Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis. Scientific Reports. 7: 40565. PMID 28074881 DOI: 10.1038/Srep40565 |
0.288 |
|
| 2016 |
Swinney ZT, Haubrich BA, Xia S, Ramesha C, Gomez SR, Guyett P, Mensa-Wilmot K, Swinney DC. A Four-Point Screening Method for Assessing Molecular Mechanism of Action (MMOA) Identifies Tideglusib as a Time-Dependent Inhibitor of Trypanosoma brucei GSK3β. Plos Neglected Tropical Diseases. 10: e0004506. PMID 26942720 DOI: 10.1371/Journal.Pntd.0004506 |
0.284 |
|
| 2018 |
Woodring JL, Behera R, Sharma A, Wiedeman J, Patel G, Singh B, Guyett P, Amata E, Erath J, Roncal N, Penn E, Leed SE, Rodriguez A, Sciotti RJ, Mensa-Wilmot K, et al. Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation. Acs Medicinal Chemistry Letters. 9: 996-1001. PMID 30344906 DOI: 10.1021/Acsmedchemlett.8B00245 |
0.282 |
|
| 2013 |
Patel G, Karver CE, Behera R, Guyett PJ, Sullenberger C, Edwards P, Roncal NE, Mensa-Wilmot K, Pollastri MP. Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis. Journal of Medicinal Chemistry. 56: 3820-32. PMID 23597080 DOI: 10.1021/Jm400349K |
0.282 |
|
| 2018 |
Ferrins L, Sharma A, Thomas SM, Mehta N, Erath J, Tanghe S, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Gillingwater K, Pollastri MP. Anilinoquinoline based inhibitors of trypanosomatid proliferation. Plos Neglected Tropical Diseases. 12: e0006834. PMID 30475800 DOI: 10.1371/Journal.Pntd.0006834 |
0.274 |
|
| 1998 |
Morris JC, Lei PS, Zhai HX, Shen TY, Mensa-Wilmot K. Inhibition of GPI phospholipase C from Trypanosoma brucei by fluoro-inositol dodecylphosphonates. Biochemical and Biophysical Research Communications. 244: 873-6. PMID 9535759 DOI: 10.1006/Bbrc.1998.8355 |
0.268 |
|
| 2016 |
Guyett PJ, Xia S, Swinney DC, Pollastri MP, Mensa-Wilmot K. Glycogen Synthase Kinase 3β Promotes the Endocytosis of Transferrin in the African Trypanosome. Acs Infectious Diseases. 2: 518-528. PMID 27626104 DOI: 10.1021/Acsinfecdis.6B00077 |
0.266 |
|
| 2018 |
Wiedeman J, Mensa-Wilmot K. A fixable probe for visualizing flagella and plasma membranes of the African trypanosome. Plos One. 13: e0197541. PMID 29768499 DOI: 10.1371/Journal.Pone.0197541 |
0.261 |
|
| 1995 |
Morris JC, Lei P, Shen TY, Mensa-Wilmot K. Glycan requirements of glycosylphosphatidylinositol phospholipase C from Trypanosoma brucei. Glucosaminylinositol derivatives inhibit phosphatidylinositol phospholipase C. The Journal of Biological Chemistry. 270: 2517-24. PMID 7852313 DOI: 10.1074/Jbc.270.6.2517 |
0.25 |
|
| 2022 |
Kumar G, Thomas B, Mensa-Wilmot K. Pseudokinase NRP1 facilitates endocytosis of transferrin in the African trypanosome. Scientific Reports. 12: 18572. PMID 36329148 DOI: 10.1038/s41598-022-22054-x |
0.243 |
|
| 2018 |
Woodring JL, Bachovchin KA, Brady KG, Gallerstein MF, Erath J, Tanghe S, Leed SE, Rodriguez A, Mensa-Wilmot K, Sciotti RJ, Pollastri MP. Corrigendum to "Optimization of physicochemical properties for 4-Anilinoquinazoline inhibitors of trypanosome proliferation" [Eur. J. Med. Chem. 141 (2017) 446-459]. European Journal of Medicinal Chemistry. 152: 515. PMID 29754075 DOI: 10.1016/J.Ejmech.2018.05.002 |
0.233 |
|
| 2022 |
Sanz-Rodriguez CE, Hoffman B, Guyett PJ, Purmal A, Singh B, Pollastri M, Mensa-Wilmot K. . Molecular Pharmacology. PMID 35605992 DOI: 10.1124/molpharm.121.000430 |
0.213 |
|
| 1989 |
Mensa-Wilmot K, Carroll K, McMacken R. Transcriptional activation of bacteriophage lambda DNA replication in vitro: regulatory role of histone-like protein HU of Escherichia coli. The Embo Journal. 8: 2393-2402. DOI: 10.1002/J.1460-2075.1989.Tb08369.X |
0.207 |
|
| 2017 |
Sullenberger C, Pique D, Ogata Y, Mensa-Wilmot K. AEE788 Inhibits Basal Body Assembly and Blocks DNA Replication in the African Trypanosome. Molecular Pharmacology. PMID 28246189 DOI: 10.1124/mol.116.106906 |
0.188 |
|
| 2010 |
ZHAI H, LEI P, MORRIS JC, MENSA-WILMOT K, SHEN TY. ChemInform Abstract: Synthesis of 2-Deoxy-2-fluorinated Inositol-1-O-dodecylphosphonates as Inhibitors of Glycosyl Phosphatidylinositol Phospholipase C. Cheminform. 27: no-no. DOI: 10.1002/CHIN.199604242 |
0.157 |
|
| 1989 |
Mensa-Wilmot K, Seaby R, Alfano C, Wold MC, Gomes B, McMacken R. Reconstitution of a nine-protein system that initiates bacteriophage λ DNA replication Journal of Biological Chemistry. 264: 2853-2861. DOI: 10.1016/S0021-9258(19)81691-5 |
0.157 |
|
| 2016 |
Thomas SM, Purmal A, Pollastri M, Mensa-Wilmot K. Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis. Scientific Reports. 6: 32083. PMID 27561392 DOI: 10.1038/srep32083 |
0.15 |
|
| 2021 |
Mensa-Wilmot K. How Physiological Targets Can Be Distinguished from Drug-binding Proteins. Molecular Pharmacology. PMID 33941662 DOI: 10.1124/molpharm.120.000186 |
0.149 |
|
| 2022 |
Sharma A, Cipriano M, Ferrins L, Hajduk SL, Mensa-Wilmot K. Hypothesis-generating proteome perturbation to identify NEU-4438 and acoziborole modes of action in the African Trypanosome. Iscience. 25: 105302. PMID 36304107 DOI: 10.1016/j.isci.2022.105302 |
0.14 |
|
| 2021 |
Sullenberger C, Hoffman B, Wiedeman J, Kumar G, Mensa-Wilmot K. Casein kinase TbCK1.2 regulates division of kinetoplast DNA, and movement of basal bodies in the African trypanosome. Plos One. 16: e0249908. PMID 33861760 DOI: 10.1371/journal.pone.0249908 |
0.123 |
|
| 2023 |
Singh B, Sharma A, Gunaganti N, Rivers M, Gadekar PK, Greene B, Chichioco M, Sanz-Rodriguez CE, Fu C, LeBlanc C, Burchfield E, Sharif N, Hoffman B, Kumar G, Purmal A, ... Mensa-Wilmot K, et al. Chemical Optimization of CBL0137 for Human African Trypanosomiasis Lead Drug Discovery. Journal of Medicinal Chemistry. PMID 36695630 DOI: 10.1021/acs.jmedchem.2c01767 |
0.119 |
|
| 2023 |
Ferrins L, Buskes MJ, Kapteyn MM, Engels HN, Enos SE, Lu C, Klug DM, Singh B, Quotadamo A, Bachovchin K, Tear WF, Spaulding AE, Forbes KC, Bag S, Rivers M, ... ... Mensa-Wilmot K, et al. Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes. Frontiers in Microbiology. 14: 1149145. PMID 37234530 DOI: 10.3389/fmicb.2023.1149145 |
0.093 |
|
| 1997 |
Garg N, Postan M, Mensa-Wilmot K, Tarleton RL. Glycosylphosphatidylinositols are required for the development of Trypanosoma cruzi amastigotes. Infection and Immunity. 65: 4055-4060. DOI: 10.1128/iai.65.10.4055-4060.1997 |
0.067 |
|
| 2023 |
Ferrins L, Buskes MJ, Kapteyn MM, Engels HN, Enos SE, Lu C, Klug DM, Singh B, Quotadamo A, Bachovchin K, Tear WF, Spaulding AE, Forbes KC, Bag S, Rivers M, ... ... Mensa-Wilmot K, et al. Corrigendum: Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes. Frontiers in Microbiology. 14: 1304196. PMID 37954236 DOI: 10.3389/fmicb.2023.1304196 |
0.052 |
|
| Hide low-probability matches. |