| Year |
Citation |
Score |
| 2018 |
Dunton CL, Purves JT, Hughes FM, Jin H, Nagatomi J. Elevated hydrostatic pressure stimulates ATP release which mediates activation of the NLRP3 inflammasome via P2X in rat urothelial cells. International Urology and Nephrology. PMID 30099658 DOI: 10.1007/S11255-018-1948-0 |
0.347 |
|
| 2018 |
Inouye BM, Hughes FM, Sexton SJ, Purves JT. The Emerging Role of Inflammasomes as Central Mediators in Inflammatory Bladder Pathology. Current Urology. 11: 57-72. PMID 29593464 DOI: 10.1159/000447196 |
0.302 |
|
| 2018 |
Hughes F, Sexton S, Leidig P, Jin H, Purves J. Mp09-16 Pharmacological Inhibition Of The Nlrp3 Inflammasome Prevents Bladder Decompensation In A Rat Model Of Chronic Bladder Outlet Obstruction The Journal of Urology. 199. DOI: 10.1016/J.Juro.2018.02.342 |
0.307 |
|
| 2017 |
Lütolf R, Hughes FM, Inouye BM, Jin H, McMains JC, Pak ES, Hannan JL, Purves JT. NLRP3/IL-1β mediates denervation during bladder outlet obstruction in rats. Neurourology and Urodynamics. PMID 28984997 DOI: 10.1002/Nau.23419 |
0.353 |
|
| 2017 |
Hughes FM, Sexton SJ, Jin H, Govada V, Purves JT. Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β. American Journal of Physiology. Renal Physiology. ajprenal.00128.2017. PMID 28592436 DOI: 10.1152/Ajprenal.00128.2017 |
0.312 |
|
| 2016 |
Hughes FM, Kennis JG, Youssef MN, Lowe DW, Shaner BE, Purves JT. The NACHT, LRR and PYD Domains-Containing Protein 3 (NLRP3) Inflammasome Mediates Inflammation and Voiding Dysfunction in a Lipopolysaccharide-Induced Rat Model of Cystitis. Journal of Clinical & Cellular Immunology. 7. PMID 27066297 DOI: 10.4172/2155-9899.1000396 |
0.37 |
|
| 2015 |
Hughes FM, Hill HM, Wood CM, Edmondson AT, Dumas A, Foo WC, Oelsen JM, Rac G, Purves JT. The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet Obstruction. The Journal of Urology. PMID 26707508 DOI: 10.1016/J.Juro.2015.12.068 |
0.341 |
|
| 2015 |
Hughes FM, Turner DP, Todd Purves J. The potential repertoire of the innate immune system in the bladder: expression of pattern recognition receptors in the rat bladder and a rat urothelial cell line (MYP3 cells). International Urology and Nephrology. PMID 26490556 DOI: 10.1007/S11255-015-1126-6 |
0.333 |
|
| 2014 |
Hughes FM, Vivar NP, Kennis JG, Pratt-Thomas JD, Lowe DW, Shaner BE, Nietert PJ, Spruill LS, Purves JT. Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation American Journal of Physiology - Renal Physiology. 306: F299-F308. PMID 24285499 DOI: 10.1152/Ajprenal.00297.2013 |
0.398 |
|
| 2013 |
Hughes FM, Corn AG, Nimmich AR, Pratt-Thomas JD, Purves JT. Cyclophosphamide Induces an Early Wave of Acrolein-Independent Apoptosis in the Urothelium. Advances in Bioscience and Biotechnology (Print). 4. PMID 24353901 DOI: 10.4236/Abb.2013.48A2002 |
0.355 |
|
| 2013 |
Hughes FM, McKeithan P, Ellett J, Armeson KE, Purves JT. Simvastatin suppresses cyclophosphamide-induced changes in urodynamics and bladder inflammation. Urology. 81: 209.e9-14. PMID 23153940 DOI: 10.1016/J.Urology.2012.08.041 |
0.317 |
|
| 2010 |
Hughes FM, Foster B, Grewal S, Sokolova IM. Apoptosis as a host defense mechanism in Crassostrea virginica and its modulation by Perkinsus marinus. Fish & Shellfish Immunology. 29: 247-57. PMID 20371290 DOI: 10.1016/J.Fsi.2010.03.003 |
0.319 |
|
| 2007 |
Jablonski EM, Mattocks MA, Sokolov E, Koniaris LG, Hughes FM, Fausto N, Pierce RH, McKillop IH. Decreased aquaporin expression leads to increased resistance to apoptosis in hepatocellular carcinoma. Cancer Letters. 250: 36-46. PMID 17084522 DOI: 10.1016/J.Canlet.2006.09.013 |
0.323 |
|
| 2006 |
Jablonski EM, Hughes FM. The potential role of caveolin-1 in inhibition of aquaporins during the AVD. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 98: 33-42. PMID 16354160 DOI: 10.1042/Bc20040131 |
0.344 |
|
| 2004 |
Sokolova IM, Evans S, Hughes FM. Cadmium-induced apoptosis in oyster hemocytes involves disturbance of cellular energy balance but no mitochondrial permeability transition. The Journal of Experimental Biology. 207: 3369-80. PMID 15326213 DOI: 10.1242/Jeb.01152 |
0.326 |
|
| 2004 |
Jablonski EM, Webb AN, McConnell NA, Riley MC, Hughes FM. Plasma membrane aquaporin activity can affect the rate of apoptosis but is inhibited after apoptotic volume decrease. American Journal of Physiology. Cell Physiology. 286: C975-85. PMID 14644770 DOI: 10.1152/Ajpcell.00180.2003 |
0.339 |
|
| 2001 |
Gross SA, Newton JM, Hughes FM. Decreased intracellular potassium levels underlie increased progesterone synthesis during ovarian follicular atresia. Biology of Reproduction. 64: 1755-60. PMID 11369605 DOI: 10.1095/Biolreprod64.6.1755 |
0.354 |
|
| 2001 |
Alexander EH, Bento JL, Hughes FM, Marriott I, Hudson MC, Bost KL. Staphylococcus aureus and Salmonella enterica serovar Dublin induce tumor necrosis factor-related apoptosis-inducing ligand expression by normal mouse and human osteoblasts. Infection and Immunity. 69: 1581-6. PMID 11179330 DOI: 10.1128/Iai.69.3.1581-1586.2001 |
0.319 |
|
| 2000 |
Perez GI, Maravei DV, Trbovich AM, Cidlowski JA, Tilly JL, Hughes FM. Identification of potassium-dependent and -independent components of the apoptotic machinery in mouse ovarian germ cells and granulosa cells. Biology of Reproduction. 63: 1358-69. PMID 11058539 DOI: 10.1095/Biolreprod63.5.1358 |
0.394 |
|
| 2000 |
Hughes FM, Cidlowski JA. Apoptotic nuclease assays. Methods in Enzymology. 322: 47-62. PMID 10914004 DOI: 10.1016/S0076-6879(00)22007-7 |
0.318 |
|
| 2000 |
Mann CL, Hughes FM, Cidlowski JA. Delineation of the signaling pathways involved in glucocorticoid-induced and spontaneous apoptosis of rat thymocytes. Endocrinology. 141: 528-38. PMID 10650932 DOI: 10.1210/Endo.141.2.7314 |
0.395 |
|
| 1999 |
Montague JW, Bortner CD, Hughes FM, Cidlowski JA. A necessary role for reduced intracellular potassium during the DNA degradation phase of apoptosis. Steroids. 64: 563-9. PMID 10503710 DOI: 10.1016/S0039-128X(99)00034-3 |
0.394 |
|
| 1999 |
Hughes FM, Cidlowski JA. Potassium is a critical regulator of apoptotic enzymes in vitro and in vivo. Advances in Enzyme Regulation. 39: 157-71. PMID 10470372 DOI: 10.1016/S0065-2571(98)00010-7 |
0.359 |
|
| 1998 |
Trbovich AM, Hughes FM, Perez GI, Kugu K, Tilly KI, Cidlowski JA, Tilly JL. High and low molecular weight DNA cleavage in ovarian granulosa cells: characterization and protease modulation in intact cells and in cell-free nuclear autodigestion assays. Cell Death and Differentiation. 5: 38-49. PMID 10200444 DOI: 10.1038/Sj.Cdd.4400299 |
0.352 |
|
| 1998 |
Hughes FM, Evans-Storms RB, Cidlowski JA. Evidence that non-caspase proteases are required for chromatin degradation during apoptosis. Cell Death and Differentiation. 5: 1017-27. PMID 9894608 DOI: 10.1038/Sj.Cdd.4400418 |
0.352 |
|
| 1998 |
Adachi H, Adams A, Hughes FM, Zhang J, Cidlowski JA, Jetten AM. Induction of apoptosis by the novel retinoid AHPN in human T-cell lymphoma cells involves caspase-dependent and independent pathways. Cell Death and Differentiation. 5: 973-83. PMID 9846184 DOI: 10.1038/Sj.Cdd.4400445 |
0.401 |
|
| 1998 |
Hughes FM, Cidlowski JA. Glucocorticoid-induced thymocyte apoptosis: protease-dependent activation of cell shrinkage and DNA degradation. The Journal of Steroid Biochemistry and Molecular Biology. 65: 207-17. PMID 9699875 DOI: 10.1016/S0960-0760(97)00188-X |
0.412 |
|
| 1998 |
Spangelo BL, Farrimond DD, Thapa M, Bulathsinghala CM, Bowman KL, Sareh A, Hughes FM, Goldstein AL, Badamchian M. Thymosin fraction 5 inhibits the proliferation of the rat neuroendocrine MMQ pituitary adenoma and C6 glioma cell lines in vitro. Endocrinology. 139: 2155-62. PMID 9529005 DOI: 10.1210/Endo.139.4.5935 |
0.354 |
|
| 1997 |
Hughes FM, Cidlowski JA. Utilization of an in vitro assay to evaluate chromatin degradation by candidate apoptotic nucleases. Cell Death and Differentiation. 4: 200-8. PMID 16465229 DOI: 10.1038/Sj.Cdd.4400221 |
0.31 |
|
| 1997 |
Bortner CD, Hughes FM, Cidlowski JA. A primary role for K+ and Na+ efflux in the activation of apoptosis. The Journal of Biological Chemistry. 272: 32436-42. PMID 9405453 DOI: 10.1074/Jbc.272.51.32436 |
0.378 |
|
| 1997 |
Hughes FM, Bortner CD, Purdy GD, Cidlowski JA. Intracellular K+ suppresses the activation of apoptosis in lymphocytes. The Journal of Biological Chemistry. 272: 30567-76. PMID 9374553 DOI: 10.1074/Jbc.272.48.30567 |
0.347 |
|
| 1997 |
Montague JW, Hughes FM, Cidlowski JA. Native recombinant cyclophilins A, B, and C degrade DNA independently of peptidylprolyl cis-trans-isomerase activity. Potential roles of cyclophilins in apoptosis. The Journal of Biological Chemistry. 272: 6677-84. PMID 9045699 DOI: 10.1074/Jbc.272.10.6677 |
0.308 |
|
| 1995 |
Hughes FM, Cidlowski JA. Glucocorticoid-induced apoptosis Current Opinion in Endocrinology & Diabetes. 2: 375-382. DOI: 10.1097/00060793-199510000-00002 |
0.349 |
|
| 1994 |
Hughes FM, Cidlowski JA. Regulation of apoptosis in S49 cells. The Journal of Steroid Biochemistry and Molecular Biology. 49: 303-10. PMID 8043493 DOI: 10.1016/0960-0760(94)90272-0 |
0.382 |
|
| 1992 |
Gorospe WC, Hughes FM, Spangelo BL. Interleukin-6: effects on and production by rat granulosa cells in vitro. Endocrinology. 130: 1750-2. PMID 1537322 DOI: 10.1210/Endo.130.3.1537322 |
0.304 |
|
| 1991 |
Hughes FM, Gorospe WC. Biochemical identification of apoptosis (programmed cell death) in granulosa cells: evidence for a potential mechanism underlying follicular atresia. Endocrinology. 129: 2415-22. PMID 1935775 DOI: 10.1210/Endo-129-5-2415 |
0.357 |
|
| Show low-probability matches. |