Alexandra M. Deaconescu, Ph.D. - Publications

Brandeis University, Waltham, MA, United States 
 2014- Molecular Biology, Cell Biology and Biochemistry Brown University, Providence, RI 
biochemistry, x-ray crystallography, TEM

31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Brugger C, Srirangam S, Deaconescu AM. IraM Remodels the RssB Segmented Helical Linker to Stabilize σ Against Degradation by ClpXP. The Journal of Biological Chemistry. 105568. PMID 38103640 DOI: 10.1016/j.jbc.2023.105568  0.792
2023 Brugger C, Schwartz J, Novick S, Tong S, Hoskins J, Majdalani N, Kim R, Filipovski M, Wickner S, Gottesman S, Griffin P, Deaconescu AM. Structure of Phosphorylated-like RssB, the Adaptor Delivering σ to the ClpXP Proteolytic Machinery, Reveals an Interface Switch for Activation. The Journal of Biological Chemistry. 105440. PMID 37949227 DOI: 10.1016/j.jbc.2023.105440  0.778
2022 Vadgama N, Kreymerman A, Campbell J, Shamardina O, Brugger C, Research Consortium GE, Deaconescu AM, Lee RT, Penkett CJ, Gifford CA, Mercola M, Nasir J, Karakikes I. SARS-CoV-2 Susceptibility and Gene Variations Within Diverse Ethnic Backgrounds. Frontiers in Genetics. 13: 888025. PMID 35571054 DOI: 10.3389/fgene.2022.888025  0.717
2021 Deaconescu AM. Mfd - at the crossroads of bacterial DNA repair, transcriptional regulation and molecular evolvability. Transcription. 12: 156-170. PMID 34674614 DOI: 10.1080/21541264.2021.1982628  0.322
2021 Brugger C, Deaconescu AM. A Gel-Based Assay for Probing Protein Translocation on dsDNA. Bio-Protocol. 11: e4094. PMID 34395731 DOI: 10.21769/BioProtoc.4094  0.756
2021 Schwartz J, Son J, Brugger C, Deaconescu AM. Phospho-dependent Signaling during the General Stress Response by the Atypical Response Regulator and ClpXP Adaptor RssB. Protein Science : a Publication of the Protein Society. PMID 33599047 DOI: 10.1002/pro.4047  0.783
2020 Brugger C, Zhang C, Suhanovsky MM, Kim DD, Sinclair AN, Lyumkis D, Deaconescu AM. Molecular determinants for dsDNA translocation by the transcription-repair coupling and evolvability factor Mfd. Nature Communications. 11: 3740. PMID 32719356 DOI: 10.1038/S41467-020-17457-1  0.764
2019 Dorich V, Brugger C, Tripathi A, Hoskins JR, Tong S, Suhanovsky MM, Sastry A, Wickner S, Gottesman S, Deaconescu AM. Structural basis for inhibition of a response regulator of σ stability by a ClpXP antiadaptor. Genes & Development. PMID 30975721 DOI: 10.1101/Gad.320168.118  0.703
2018 Vemu A, Szczesna E, Zehr EA, Spector JO, Grigorieff N, Deaconescu AM, Roll-Mecak A. Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation. Science (New York, N.Y.). 361. PMID 30139843 DOI: 10.1016/J.Bpj.2018.11.866  0.576
2018 Le TT, Yang Y, Tan C, Suhanovsky MM, Fulbright RM, Inman JT, Li M, Lee J, Perelman S, Roberts JW, Deaconescu AM, Wang MD. Mfd Dynamically Regulates Transcription via a Release and Catch-Up Mechanism. Cell. 173: 1823. PMID 29906451 DOI: 10.1016/j.cell.2018.06.002  0.736
2018 Deaconescu A, Dorich V, Suhanovsky M, Tripathi A, Tong S, Brugger C, Hoskins J, Wickner S, Gottesman S. Structural basis for RpoS regulation via ClpXP adaptor/anti-adaptor pairs Acta Crystallographica Section a Foundations and Advances. 74: e44-e44. DOI: 10.1107/S2053273318094548  0.677
2018 Le TT, Yang Y, Tan C, Suhanovsky M, Fulbright RM, Inman JT, Li M, Lee J, Roberts JW, Deaconescu AM, Wang MD. MFD Dynamically Regulates Transcription Biophysical Journal. 114: 247a. DOI: 10.1016/J.Bpj.2017.11.1377  0.752
2017 Le TT, Yang Y, Tan C, Suhanovsky MM, Fulbright RM, Inman JT, Li M, Lee J, Perelman S, Roberts JW, Deaconescu AM, Wang MD. Mfd Dynamically Regulates Transcription via a Release and Catch-Up Mechanism. Cell. PMID 29224782 DOI: 10.1016/J.Cell.2017.11.017  0.77
2016 Deaconescu AM, Suhanovsky MM. From Mfd to TRCF and Back Again - A Perspective on Bacterial Transcription-Coupled Nucleotide Excision Repair. Photochemistry and Photobiology. PMID 27859304 DOI: 10.1111/Php.12661  0.765
2016 Kutter S, Eichner T, Deaconescu AM, Kern D. Regulation of microtubule assembly by tau and not by Pin1. Journal of Molecular Biology. PMID 26996940 DOI: 10.1016/J.Jmb.2016.03.010  0.321
2015 Spector J, Szyk A, Deaconescu AM, Valenstein M, Goodman B, Kormendi V, Grigorieff N, Roll-Mecak A. Molecular Basis for Age-Dependent Acetylation by Tubulin Acetyltransferase Biophysical Journal. 108: 449a. DOI: 10.1016/J.Bpj.2014.11.2449  0.6
2015 Roll-Mecak A, Szyk A, Deaconescu A, Spector J, Valenstein M, Grigorieff N. Molecular Basis for Age-Dependent Microtubule Acetylation Biophysical Journal. 108: 448a. DOI: 10.1016/J.Bpj.2014.11.2447  0.36
2014 Szyk A, Deaconescu AM, Spector J, Goodman B, Valenstein ML, Ziolkowska NE, Kormendi V, Grigorieff N, Roll-Mecak A. Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. Cell. 157: 1405-15. PMID 24906155 DOI: 10.1016/J.Cell.2014.03.061  0.586
2014 Szyk A, Deaconescu A, Piszczek G, Roll-Mecak A. Tubulin tyrosine ligase - structural and functional studies Acta Crystallographica Section a Foundations and Advances. 70: C479-C479. DOI: 10.1107/S2053273314095205  0.389
2013 Deaconescu AM. RNA polymerase between lesion bypass and DNA repair. Cellular and Molecular Life Sciences : Cmls. 70: 4495-509. PMID 23807206 DOI: 10.1007/S00018-013-1384-3  0.417
2012 Deaconescu AM, Artsimovitch I, Grigorieff N. Interplay of DNA repair with transcription: from structures to mechanisms. Trends in Biochemical Sciences. 37: 543-52. PMID 23084398 DOI: 10.1016/J.Tibs.2012.09.002  0.656
2012 Deaconescu AM, Sevostyanova A, Artsimovitch I, Grigorieff N. Nucleotide excision repair (NER) machinery recruitment by the transcription-repair coupling factor involves unmasking of a conserved intramolecular interface. Proceedings of the National Academy of Sciences of the United States of America. 109: 3353-8. PMID 22331906 DOI: 10.1073/Pnas.1115105109  0.65
2011 Szyk A, Deaconescu AM, Piszczek G, Roll-Mecak A. Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin. Nature Structural & Molecular Biology. 18: 1250-8. PMID 22020298 DOI: 10.1038/Nsmb.2148  0.409
2011 Kutter S, Deaconescu A, Kern D. Tau vs. Glycerol - A Kinetic Study of the Tubulin Polymerization Biophysical Journal. 100: 449a. DOI: 10.1016/J.Bpj.2010.12.2648  0.301
2010 Okada K, Bartolini F, Deaconescu AM, Moseley JB, Dogic Z, Grigorieff N, Gundersen GG, Goode BL. Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1. The Journal of Cell Biology. 189: 1087-96. PMID 20566685 DOI: 10.1083/Jcb.201001016  0.594
2009 Okada K, Deaconescu AM, Moseley JB, Dogic Z, Grigorieff N, Goode BL. Starting Actin Filaments Anew - Adenomatous Polyposis Coli Is an Actin Nucleator Biophysical Journal. 96: 124a. DOI: 10.1016/J.Bpj.2008.12.552  0.584
2007 Deaconescu AM, Savery N, Darst SA. The bacterial transcription repair coupling factor. Current Opinion in Structural Biology. 17: 96-102. PMID 17239578 DOI: 10.1016/J.Sbi.2007.01.005  0.433
2006 Deaconescu AM, Chambers AL, Smith AJ, Nickels BE, Hochschild A, Savery NJ, Darst SA. Structural basis for bacterial transcription-coupled DNA repair. Cell. 124: 507-20. PMID 16469698 DOI: 10.1016/J.Cell.2005.11.045  0.53
2005 Deaconescu AM, Darst SA. Crystallization and preliminary structure determination of Escherichia coli Mfd, the transcription-repair coupling factor. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 1062-4. PMID 16511235 DOI: 10.1107/S1744309105035876  0.418
2002 Deaconescu AM, Roll-Mecak A, Bonanno JB, Gerchman SE, Kycia H, Studier FW, Burley SK. X-ray structure of Saccharomyces cerevisiae homologous mitochondrial matrix factor 1 (Hmf1). Proteins. 48: 431-6. PMID 12112709 DOI: 10.1002/Prot.10151  0.488
2002 Deaconescu AM, Roll-Mecak A, Bonanno JB, Gerchman SE, Kycia H, Studier FW, Burley SK. Crystal structure ofSaccharomyces cerevisiaehomologous mitochondrial matrix factor 1 (Hmf1) Acta Crystallographica Section a Foundations of Crystallography. 58: c299-c299. DOI: 10.1107/S0108767302096940  0.492
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