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Daniel A. Harki - Publications

Affiliations: 
1999-2005 Medicinal Chemistry University of Minnesota, Twin Cities, Minneapolis, MN 
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51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Divakaran A, Harki DA, Pomerantz WCK. Recent progress and structural analyses of domain-selective BET inhibitors. Medicinal Research Reviews. PMID 36971240 DOI: 10.1002/med.21942  0.76
2022 Divakaran A, Scholtz CR, Zahid H, Lin W, Griffith EC, Lee RE, Chen T, Harki DA, Pomerantz WCK. Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader. Acs Medicinal Chemistry Letters. 13: 1621-1627. PMID 36262390 DOI: 10.1021/acsmedchemlett.2c00300  0.747
2022 Moghadasi SA, Esler MA, Otsuka Y, Becker JT, Moraes SN, Anderson CB, Chamakuri S, Belica C, Wick C, Harki DA, Young DW, Scampavia L, Spicer TP, Shi K, Aihara H, et al. Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M/3CL in Living Cells. Mbio. e0078422. PMID 35471084 DOI: 10.1128/mbio.00784-22  0.602
2022 Ghani LA, Yusenko MV, Frank D, Moorthy R, Widen JC, Dörner W, Khandanpour C, Harki DA, Klempnauer KH. A synthetic covalent ligand of the C/EBPβ transactivation domain inhibits acute myeloid leukemia cells. Cancer Letters. PMID 35077804 DOI: 10.1016/j.canlet.2022.01.024  0.757
2022 Cui H, Divakaran A, Hoell ZJ, Ellingson MO, Scholtz CR, Zahid H, Johnson JA, Griffith EC, Gee CT, Lee AL, Khanal S, Shi K, Aihara H, Shah VH, Lee RE, ... Harki DA, et al. A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes. Journal of Medicinal Chemistry. PMID 35007061 DOI: 10.1021/acs.jmedchem.1c01779  0.752
2021 Cui H, Carlson AS, Schleiff MA, Divakaran A, Johnson JA, Buchholz CR, Zahid H, Vail NR, Shi K, Aihara H, Harki DA, Miller GP, Topczewski JJ, Pomerantz WCK. 4-Methyl-1,2,3-Triazoles as -Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity. Journal of Medicinal Chemistry. PMID 34236185 DOI: 10.1021/acs.jmedchem.1c00933  0.756
2020 Jackson PA, Schares HAM, Jones KFM, Widen JC, Dempe DP, Grillet F, Cuellar ME, Walters MA, Harki DA, Brummond KM. Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity. Journal of Medicinal Chemistry. PMID 33201697 DOI: 10.1021/acs.jmedchem.0c01464  0.762
2020 Pomerantz WCK, Cui H, Divakaran A, Pandey AK, Johnson JA, Zahid H, Hoell ZJ, Ellingson MO, Shi K, Aihara H, Harki DA. Selective N-terminal BRD4 bromodomain inhibitors by targeting non-conserved residues and structured water displacement. Angewandte Chemie (International Ed. in English). PMID 32975004 DOI: 10.1002/anie.202008625  0.744
2020 Passow KT, Antczak NM, Sturla SJ, Harki DA. Synthesis of 4-Cyanoindole Nucleosides, 4-Cyanoindole-2'-Deoxyribonucleoside-5'-Triphosphate (4CIN-TP), and Enzymatic Incorporation of 4CIN-TP into DNA. Current Protocols in Nucleic Acid Chemistry. 80: e101. PMID 31909864 DOI: 10.1002/Cpnc.101  0.318
2019 Kvach MV, Barzak FM, Harjes S, Schares HAM, Kurup HM, Jones KF, Sutton L, Donahue J, D'Aquila RT, Jameson GB, Harki DA, Krause KL, Harjes E, Filichev V. Differential inhibition of APOBEC3 DNA-mutator isozymes by fluoro- versus non-fluoro-substituted 2'-deoxyzebularine embedded in single-stranded DNA. Chembiochem : a European Journal of Chemical Biology. PMID 31633265 DOI: 10.1002/Cbic.201900505  0.385
2018 Kvach MV, Barzak FM, Harjes S, Schares HAM, Jameson GB, Ayoub AM, Moorthy R, Aihara H, Harris RS, Filichev V, Harki DA, Harjes E. Inhibiting APOBEC3 activity with single-stranded DNA containing 2'-deoxyzebularine analogs. Biochemistry. PMID 30418757 DOI: 10.1021/Acs.Biochem.8B00858  0.4
2018 Divakaran A, Talluri SK, Ayoub AM, Mishra N, Cui H, Widen JC, Berndt N, Zhu JY, Carlson AS, Topczewski JJ, Schönbrunn E, Harki DA, Pomerantz WCK. Molecular Basis for the N-Terminal Bromodomain and Extra Terminal (BET) Family Selectivity of a Dual Kinase-Bromodomain Inhibitor. Journal of Medicinal Chemistry. PMID 30253095 DOI: 10.1021/Acs.Jmedchem.8B01248  0.781
2018 Wagner JR, Demir O, Carpenter MA, Aihara H, Harki DA, Harris RS, Amaro RE. Determinants of Oligonucleotide Selectivity of APOBEC3B. Journal of Chemical Information and Modeling. PMID 30130104 DOI: 10.1021/Acs.Jcim.8B00427  0.315
2018 Naumann JA, Widen JC, Jonart LA, Ebadi M, Tang J, Gordon DJ, Harki DA, Gordon PM. SN-38 conjugated gold nanoparticles activated by Ewing sarcoma specific mRNAs exhibit in vitro and in vivo efficacy. Bioconjugate Chemistry. PMID 29412642 DOI: 10.1021/Acs.Bioconjchem.7B00774  0.757
2018 Widen JC, Kempema AM, Baur JW, Skopec HM, Edwards JT, Brown TJ, Brown DA, Meece FA, Harki DA. Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles. Chemmedchem. PMID 29349898 DOI: 10.1002/Cmdc.201700752  0.761
2018 Widen JC, Kempema AM, Baur JW, Skopec HM, Edwards JT, Brown TJ, Brown DA, Meece FA, Harki DA. Front Cover: Helenalin Analogues Targeting NF-κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles (ChemMedChem 4/2018) Chemmedchem. 13: 288-288. DOI: 10.1002/Cmdc.201800079  0.746
2017 Olson ME, Harris RS, Harki DA. APOBEC Enzymes as Targets for Virus and Cancer Therapy. Cell Chemical Biology. PMID 29153851 DOI: 10.1016/J.Chembiol.2017.10.007  0.609
2017 Dulin D, Arnold JJ, van Laar T, Oh HS, Lee C, Perkins AL, Harki DA, Depken M, Cameron CE, Dekker NH. Signatures of Nucleotide Analog Incorporation by an RNA-Dependent RNA Polymerase Revealed Using High-Throughput Magnetic Tweezers. Cell Reports. 21: 1063-1076. PMID 29069588 DOI: 10.1016/J.Celrep.2017.10.005  0.33
2017 Widen JC, Kempema AM, Villalta PW, Harki DA. Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile. Acs Chemical Biology. 12: 102-113. PMID 28103680 DOI: 10.1021/Acschembio.6B00751  0.795
2016 Breunig SL, Olson ME, Harki DA. Rapid, Microwave Accelerated Synthesis of [1,2,4]Triazolo[3,4-b][1,3,4]oxadiazoles from 4-Acylamino-1,2,4-Triazoles. Tetrahedron Letters. 57: 4056-4060. PMID 28138199 DOI: 10.1016/J.Tetlet.2016.07.082  0.764
2016 Jackson PA, Widen JC, Harki DA, Brummond KM. Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions. Journal of Medicinal Chemistry. PMID 27996267 DOI: 10.1021/Acs.Jmedchem.6B00788  0.763
2016 Shi K, Carpenter MA, Banerjee S, Shaban NM, Kurahashi K, Salamango DJ, McCann JL, Starrett GJ, Duffy JV, Demir Ö, Amaro RE, Harki DA, Harris RS, Aihara H. Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B. Nature Structural & Molecular Biology. PMID 27991903 DOI: 10.1038/Nsmb.3344  0.351
2016 Richards CM, Li M, Perkins AL, Rathore A, Harki DA, Harris RS. Reassessing APOBEC3G inhibition by HIV-1 Vif-derived peptides. Journal of Molecular Biology. PMID 27887868 DOI: 10.1016/J.Jmb.2016.11.012  0.309
2016 Wells SM, Widen JC, Harki DA, Brummond KM. Alkyne Ligation Handles: Propargylation of Hydroxyl, Sulfhydryl, Amino, and Carboxyl Groups via the Nicholas Reaction. Organic Letters. PMID 27570975 DOI: 10.1021/Acs.Orglett.6B02088  0.737
2016 Struntz NB, Harki DA. Catch and Release DNA Decoys: Capture and Photochemical Dissociation of NF-κB Transcription Factors. Acs Chemical Biology. PMID 27054264 DOI: 10.1021/Acschembio.6B00130  0.774
2016 Breunig SL, Olson ME, Harki DA. Rapid, microwave accelerated synthesis of [1,2,4]triazolo[3,4-b][1,3,4]oxadiazoles from 4-acylamino-1,2,4-triazoles Tetrahedron Letters. 57: 4056-4060. DOI: 10.1016/j.tetlet.2016.07.082  0.765
2015 Kerr JP, Robison P, Shi G, Bogush AI, Kempema AM, Hexum JK, Becerra N, Harki DA, Martin SS, Raiteri R, Prosser BL, Ward CW. Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle. Nature Communications. 6: 8526. PMID 26446751 DOI: 10.1038/Ncomms9526  0.731
2015 Olson ME, Abate-Pella D, Perkins AL, Li M, Carpenter MA, Rathore A, Harris RS, Harki DA. Oxidative Reactivities of 2-Furylquinolines: Ubiquitous Scaffolds in Common High-Throughput Screening Libraries. Journal of Medicinal Chemistry. PMID 26358009 DOI: 10.1021/Acs.Jmedchem.5B00930  0.57
2015 Kempema AM, Widen JC, Hexum JK, Andrews TE, Wang D, Rathe SK, Meece FA, Noble KE, Sachs Z, Largaespada DA, Harki DA. Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues. Bioorganic & Medicinal Chemistry. 23: 4737-45. PMID 26088334 DOI: 10.1016/J.Bmc.2015.05.037  0.749
2015 Hexum JK, Becker CM, Kempema AM, Ohlfest JR, Largaespada DA, Harki DA. Parthenolide prodrug LC-1 slows growth of intracranial glioma. Bioorganic & Medicinal Chemistry Letters. 25: 2493-5. PMID 25978958 DOI: 10.1016/J.Bmcl.2015.04.058  0.733
2015 Brand LJ, Olson ME, Ravindranathan P, Guo H, Kempema AM, Andrews TE, Chen X, Raj GV, Harki DA, Dehm SM. EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer. Oncotarget. 6: 3811-24. PMID 25669987 DOI: 10.18632/Oncotarget.2924  0.772
2015 Kerr JP, Prosser BL, Shi G, Robison P, Kempema AM, Hexum JK, Harki DA, Martin SS, Raiteri R, Ward CW. Post-Translational Modification of Tubulin Amplifies X-ROS Signaling in Striated Muscle Biophysical Journal. 108: 592a. DOI: 10.1016/J.Bpj.2014.11.3226  0.745
2013 Andrews TE, Wang D, Harki DA. Cell surface markers of cancer stem cells: diagnostic macromolecules and targets for drug delivery. Drug Delivery and Translational Research. 3: 121-42. PMID 25787981 DOI: 10.1007/S13346-012-0075-1  0.721
2013 Wen B, Hexum JK, Widen JC, Harki DA, Brummond KM. A redox economical synthesis of bioactive 6,12-guaianolides. Organic Letters. 15: 2644-7. PMID 23662902 DOI: 10.1021/Ol400904Y  0.78
2013 Olson ME, Li M, Harris RS, Harki DA. Small-molecule APOBEC3G DNA cytosine deaminase inhibitors based on a 4-amino-1,2,4-triazole-3-thiol scaffold. Chemmedchem. 8: 112-7. PMID 23180603 DOI: 10.1002/Cmdc.201200411  0.604
2012 Struntz NB, Hu T, White BR, Olson ME, Harki DA. Inhibition of guanosine monophosphate synthetase by the substrate enantiomer L-XMP. Chembiochem : a European Journal of Chemical Biology. 13: 2517-20. PMID 23097382 DOI: 10.1002/Cbic.201200503  0.741
2012 Hexum JK, Tello-Aburto R, Struntz NB, Harned AM, Harki DA. Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling. Acs Medicinal Chemistry Letters. 3: 459-464. PMID 22866208 DOI: 10.1021/Ml300034A  0.796
2012 Li M, Shandilya SM, Carpenter MA, Rathore A, Brown WL, Perkins AL, Harki DA, Solberg J, Hook DJ, Pandey KK, Parniak MA, Johnson JR, Krogan NJ, Somasundaran M, Ali A, et al. First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G. Acs Chemical Biology. 7: 506-17. PMID 22181350 DOI: 10.1021/Cb200440Y  0.387
2012 Olson ME, Li M, Harris RS, Harki DA. Back Cover: Small-Molecule APOBEC3G DNA Cytosine Deaminase Inhibitors Based on a 4-Amino-1,2,4-triazole-3-thiol Scaffold (ChemMedChem 1/2013) Chemmedchem. 8: 172-172. DOI: 10.1002/Cmdc.201290068  0.599
2011 Zhang Y, Sicot G, Cui X, Vogel M, Wuertzer CA, Lezon-Geyda K, Wheeler J, Harki DA, Muzikar KA, Stolper DA, Dervan PB, Perkins AS. Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide. Biochemistry. 50: 10431-41. PMID 22039883 DOI: 10.1021/Bi200962U  0.787
2009 Chenoweth DM, Harki DA, Dervan PB. Oligomerization route to Py-Im polyamide macrocycles. Organic Letters. 11: 3590-3. PMID 19627138 DOI: 10.1021/Ol901311M  0.677
2009 Chenoweth DM, Harki DA, Dervan PB. Solution-phase synthesis of pyrrole-imidazole polyamides. Journal of the American Chemical Society. 131: 7175-81. PMID 19413320 DOI: 10.1021/Ja901307M  0.688
2009 Chenoweth DM, Harki DA, Phillips JW, Dose C, Dervan PB. Cyclic pyrrole-imidazole polyamides targeted to the androgen response element. Journal of the American Chemical Society. 131: 7182-8. PMID 19413319 DOI: 10.1021/Ja901309Z  0.705
2008 Harki DA, Satyamurthy N, Stout DB, Phelps ME, Dervan PB. In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography. Proceedings of the National Academy of Sciences of the United States of America. 105: 13039-44. PMID 18753620 DOI: 10.1073/Pnas.0806308105  0.488
2008 Zamyatkin DF, Parra F, Alonso JM, Harki DA, Peterson BR, Grochulski P, Ng KK. Structural insights into mechanisms of catalysis and inhibition in Norwalk virus polymerase. The Journal of Biological Chemistry. 283: 7705-12. PMID 18184655 DOI: 10.1074/Jbc.M709563200  0.619
2008 Graci JD, Too K, Smidansky ED, Edathil JP, Barr EW, Harki DA, Galarraga JE, Bollinger JM, Peterson BR, Loakes D, Brown DM, Cameron CE. Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues. Antimicrobial Agents and Chemotherapy. 52: 971-9. PMID 18180344 DOI: 10.1128/Aac.01056-07  0.777
2008 Sicot G, Vogel M, Zhang Y, Harki DA, Lezon-Geyda K, Dervan P, Perkins AS. Development of a Novel Polyamide-Based Agent to Inhibit EVI1 Function Blood. 112: 2660-2660. DOI: 10.1182/Blood.V112.11.2660.2660  0.491
2007 Graci JD, Harki DA, Korneeva VS, Edathil JP, Too K, Franco D, Smidansky ED, Paul AV, Peterson BR, Brown DM, Loakes D, Cameron CE. Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue. Journal of Virology. 81: 11256-66. PMID 17686844 DOI: 10.1128/Jvi.01028-07  0.772
2007 Harki DA, Graci JD, Edathil JP, Castro C, Cameron CE, Peterson BR. Synthesis of a universal 5-nitroindole ribonucleotide and incorporation into RNA by a viral RNA-dependent RNA polymerase. Chembiochem : a European Journal of Chemical Biology. 8: 1359-62. PMID 17600792 DOI: 10.1002/Cbic.200700160  0.765
2006 Harki DA, Graci JD, Galarraga JE, Chain WJ, Cameron CE, Peterson BR. Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases. Journal of Medicinal Chemistry. 49: 6166-9. PMID 17034123 DOI: 10.1021/Jm060872X  0.637
2002 Harki DA, Graci JD, Korneeva VS, Ghosh SK, Hong Z, Cameron CE, Peterson BR. Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole. Biochemistry. 41: 9026-33. PMID 12119016 DOI: 10.1021/Bi026120W  0.632
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