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Paul R. Carlier, Ph.D.

Affiliations:	1988-1991	Chemistry	Polaroid, Sankt-Peterburg, Saint Petersburg, Russia
	1991-2000	Chemistry	Hong Kong Univ. of Sci. & Technology
	2000-	Chemistry	Virginia Polytechnic Institute and State University, Blacksburg, VA, United States

Area:

Stereoselective synthesis, medicinal chemistry

Website:

http://www.carliergroup.chem.vt.edu

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Mean distance: 7.72

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Parents

K. Barry Sharpless

grad student

1983-1988

Children

Polo C. Lam	grad student	2004	Virginia Tech
Ella C. Clement	grad student	2005	Virginia Tech
Stephanie L. MacQuarrie	grad student	2005	Virginia Tech
Joseph C. DeGuzman	grad student	2006	Virginia Tech
Danny C. Hsu	grad student	2007	Virginia Tech
Yiqun Zhang	grad student	2007	Virginia Tech
Henry J. Harmon	grad student	2008	Virginia Tech
Larry D. Williams	grad student	2008	Virginia Tech
Nipa Deora	grad student	2010	Virginia Tech
Christopher J. Monceaux	grad student	2010	Virginia Tech
Neeraj Patwardhan	grad student	2012	Virginia Tech
Astha Verma	grad student	2014	Virginia Tech
Eugene Camerino	grad student	2015	Virginia Tech
Dinesh Nath	post-doc
Amarraj Chakraborty	post-doc	2021-	Virginia Tech

Collaborators

BETA: Related publications

Publications

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Ding S, Ghavami M, Butler JH, et al. (2020) Probing the B- & C-rings of the antimalarial tetrahydro-β-carboline MMV008138 for steric and conformational constraints. Bioorganic & Medicinal Chemistry Letters. 127520
Ding S, Fike KR, Klemba M, et al. (2020) In vitro and in vivo evaluation of the antimalarial MMV665831 and structural analogs. Bioorganic & Medicinal Chemistry Letters. 30: 127348
Deora N, Carlier PR. (2019) A computational study of regioselectivity in aluminum hydride ring-opening of cis- and trans-4-t-butyl and 3-methylcyclohexene oxides. Organic & Biomolecular Chemistry
Cagašová K, Ghavami M, Yao ZK, et al. (2019) Questioning the γ-gauche effect: stereoassignment of 1,3-disubstituted-tetrahydro-β-carbolines using H-H coupling constants. Organic & Biomolecular Chemistry
Mutunga JM, Ma M, Chen QH, et al. (2019) Mosquito Acetylcholinesterase as a Target for Novel Phenyl-Substituted Carbamates. International Journal of Environmental Research and Public Health. 16
Carlier PR, Chen QH, Verma A, et al. (2018) Select β- and γ-branched 1-alkylpyrazol-4-yl methylcarbamates exhibit high selectivity for inhibition of versus human acetylcholinesterase. Pesticide Biochemistry and Physiology. 151: 32-39
Cheung J, Mahmood A, Kalathur R, et al. (2018) Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance. Structure (London, England : 1993). 26: 130-136.e2
Clements JS, Islam R, Sun B, et al. (2017) N'-mono- and N, N'-diacyl derivatives of benzyl and arylhydrazines as contact insecticides against adult Anopheles gambiae. Pesticide Biochemistry and Physiology. 143: 33-38
Ghavami M, Merino EF, Yao Z, et al. (2017) Biological studies and target-engagement of the 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD)-targeting antimalarial agent (1R,3S)-MMV008138 and analogs. Acs Infectious Diseases
Han Q, Wong DM, Robinson H, et al. (2017) Crystal structure of acetylcholinesterase catalytic subunits of the malaria vector Anopheles gambiae. Insect Science

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