Melisa Osborne, Ph.D.

Affiliations: 
Biochemistry Brandeis University, Waltham, MA, United States 
Area:
Single-molecule biochemistry
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"Melisa Osborne"
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Jeff Gelles grad student 2011 Brandeis
 (Regulatory Mechanisms of the Bacterial Transcription Elongation Factors GreB and NusA.)
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Publications

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Chang CY, Osborne ML, Bajic D, et al. (2020) Artificially selecting bacterial communities using propagule strategies. Evolution; International Journal of Organic Evolution
Sanchez-Gorostiaga A, Bajić D, Osborne ML, et al. (2019) High-order interactions distort the functional landscape of microbial consortia. Plos Biology. 17: e3000550
Tetone LE, Friedman LJ, Osborne ML, et al. (2017) Dynamics of GreB-RNA polymerase interaction allow a proofreading accessory protein to patrol for transcription complexes needing rescue. Proceedings of the National Academy of Sciences of the United States of America
Ramsey KM, Osborne ML, Vvedenskaya IO, et al. (2015) Ubiquitous promoter-localization of essential virulence regulators in Francisella tularensis. Plos Pathogens. 11: e1004793
Tetone LE, Friedman LJ, Osborne ML, et al. (2015) Dynamics of GreB Interactions with RNA Polymerase: How a Regulatory Protein may Patrol the Genome for Transcription Complexes to Rescue Biophysical Journal. 108: 507a-508a
Volpon L, Osborne MJ, Culjkovic-Kraljacic B, et al. (2013) EIF4E3, a new actor in mRNA metabolism and tumor suppression Cell Cycle. 12: 1159-1160
Volpon L, Osborne MJ, Zahreddine H, et al. (2013) Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate. Biochemical and Biophysical Research Communications. 434: 614-9
Garcia HG, Sanchez A, Boedicker JQ, et al. (2012) Operator sequence alters gene expression independently of transcription factor occupancy in bacteria. Cell Reports. 2: 150-61
Siddiqui N, Tempel W, Nedyalkova L, et al. (2012) Structural insights into the allosteric effects of 4EBP1 on the eukaryotic translation initiation factor eIF4E Journal of Molecular Biology. 415: 781-792
Sanchez A, Osborne ML, Friedman LJ, et al. (2011) Mechanism of transcriptional repression at a bacterial promoter by analysis of single molecules. The Embo Journal. 30: 3940-6
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