Douglas J. Kojetin, Ph.D.
Affiliations: | 1995-1997 | IUPUI, Indianapolis, IN, United States | |
| 1998-2000 | Purdue University, West Lafayette, IN, United States | ||
| 2000-2005 | North Carolina State University, Raleigh, NC | ||
| 2005-2009 | University of Cincinnati, Cincinnati, OH | ||
| 2009- | Scripps Research Institute |
Area:
Nuclear receptors, NMR spectroscopy, Structural biologyWebsite:
https://www.kojetinlab.orgGoogle:
"Douglas Kojetin"Mean distance: 9.57
Parents
Sign in to add mentor| John Cavanagh | grad student | 2000-2005 | NCSU | |
| (Structural characterization of two-component signal transduction proteins and calbindin D(28k).) | ||||
| Mark Rance | post-doc | 2005-2009 | University of Cincinnati | |
| Thomas P Burris | post-doc | 2009-2010 | Scripps Research Institute (Cell Biology Tree) | |
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Publications
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| Williams CC, Chuck J, Munoz-Tello P, et al. (2025) A tethering mechanism underlies Pin1-catalyzed proline isomerization at a noncanonical site. Proceedings of the National Academy of Sciences of the United States of America. 122: e2414606122 |
| Yu X, He Y, Kamenecka TM, et al. (2025) Towards a unified molecular mechanism for ligand-dependent activation of NR4A-RXR heterodimers. Biorxiv : the Preprint Server For Biology |
| Arifova L, MacTavish BS, Laughlin Z, et al. (2025) Shifting the PPARγ conformational ensemble towards a transcriptionally repressive state improves covalent inhibitor efficacy. Biorxiv : the Preprint Server For Biology |
| Shang J, Kojetin DJ. (2024) Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ. Elife. 13 |
| Williams CC, Chuck J, Munoz-Tello P, et al. (2024) A tethering mechanism underlies Pin1-catalyzed proline isomerization at a noncanonical site. Biorxiv : the Preprint Server For Biology |
| Shang J, Kojetin DJ. (2024) Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ. Biorxiv : the Preprint Server For Biology |
| Yu X, Shang J, Kojetin DJ. (2023) Molecular basis of ligand-dependent Nurr1-RXRα activation. Elife. 12 |
| Shang J, Kojetin DJ. (2021) Structural mechanism underlying ligand binding and activation of PPARγ. Structure (London, England : 1993) |
| Mosure SA, Strutzenberg TS, Shang J, et al. (2021) Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ. Science Advances. 7 |
| Munoz-Tello P, Lin H, Khan P, et al. (2020) Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1. Journal of Medicinal Chemistry |