Justin Ashworth, Ph.D.
Affiliations: | University of Washington, Seattle, Seattle, WA |
Area:
protein structure predictionGoogle:
"Justin Ashworth"Parents
Sign in to add mentor| David Baker | grad student | 2009 | University of Washington | |
| (Computational physical modeling and design of protein -DNA interactions.) | ||||
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Publications
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| Plaisier CL, Lo FY, Ashworth J, et al. (2014) Evolution of context dependent regulation by expansion of feast/famine regulatory proteins. Bmc Systems Biology. 8: 122 |
| Ashworth J, Bernard B, Reynolds S, et al. (2014) Structure-based predictions broadly link transcription factor mutations to gene expression changes in cancers. Nucleic Acids Research. 42: 12973-83 |
| Ashworth J, Plaisier CL, Lo FY, et al. (2014) Inference of expanded Lrp-like feast/famine transcription factor targets in a non-model organism using protein structure-based prediction. Plos One. 9: e107863 |
| Thyme SB, Boissel SJ, Arshiya Quadri S, et al. (2014) Reprogramming homing endonuclease specificity through computational design and directed evolution. Nucleic Acids Research. 42: 2564-76 |
| Ashworth J, Wurtmann EJ, Baliga NS. (2012) Reverse engineering systems models of regulation: discovery, prediction and mechanisms. Current Opinion in Biotechnology. 23: 598-603 |
| Fleishman SJ, Leaver-Fay A, Corn JE, et al. (2011) RosettaScripts: a scripting language interface to the Rosetta macromolecular modeling suite. Plos One. 6: e20161 |
| Ashworth J, Taylor GK, Havranek JJ, et al. (2010) Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs. Nucleic Acids Research. 38: 5601-8 |
| Thyme SB, Jarjour J, Takeuchi R, et al. (2009) Exploitation of binding energy for catalysis and design. Nature. 461: 1300-4 |
| Ashworth J, Baker D. (2009) Assessment of the optimization of affinity and specificity at protein-DNA interfaces. Nucleic Acids Research. 37: e73 |
| Eastberg JH, McConnell Smith A, Zhao L, et al. (2007) Thermodynamics of DNA target site recognition by homing endonucleases. Nucleic Acids Research. 35: 7209-21 |