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Tina L. Yuan, Ph.D.

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
PI3K and cancer metabolism
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"Tina Yuan"
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Lewis C. Cantley grad student 2010 Harvard
 (Contributions of phosphoinositide-3-kinase to tumorigenesis both inside and outside the tumor.)

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Publications

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Prahallad A, Weiss A, Voshol H, et al. (2023) CRISPR screening identifies mechanisms of resistance to KRASG12C and SHP2 inhibitor combinations in non-small cell lung cancer. Cancer Research
Sulahian R, Kwon JJ, Walsh KH, et al. (2019) Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers. Cell Reports. 29: 118-134.e8
Lee CS, Lee LC, Yuan TL, et al. (2019) MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival. Proceedings of the National Academy of Sciences of the United States of America
Yuan TL, Amzallag A, Bagni R, et al. (2018) Differential Effector Engagement by Oncogenic KRAS. Cell Reports. 22: 1889-1902
Amzallag A, Yuan TL, Bagni R, et al. (2015) Abstract LB-247: Querying the RAS genomic network with siRNAs and and flow cytometry: Automatic, multidimensional phenotyping of 135 cancer cell lines by Gaussian mixture fitting and expectation maximization Cancer Research. 75
Yuan TL, Bagni R, Yi M, et al. (2015) Abstract 4690: Next-generation screen for integrative subtyping and target discovery for KRAS-mutant cancer Cancer Research. 75: 4690-4690
Yuan TL, Fellmann C, Lee CS, et al. (2014) Development of siRNA payloads to target KRAS-mutant cancer. Cancer Discovery. 4: 1182-97
Yuan TL, McCormick F. (2013) Killing tumors by keeping ras and PI3' kinase apart. Cancer Cell. 24: 562-3
Yuan TL, Lee C, Fellmann C, et al. (2013) Abstract LB-94: Nanoparticle-based RNAi therapy for the delivery of personalized siRNA payloads to KRAS-driven tumors. Cancer Research. 73
Yuan TL, Wulf G, Burga L, et al. (2011) Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations. Current Biology : Cb. 21: 173-83
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