Chong Han, Ph.D.

Affiliations: 
2010- Small Molecule Process Chemistry Genentech, Inc., San Francisco, CA, United States 
Area:
Synthesis of complex natural products; Cu, Pd, Zr-catalyzed transformations
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"Chong Han"
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SNBCP

Parents

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John A. Porco grad student 2008 Boston University
 (Synthesis of N-acyl vinylogous urea-containing natural products and development and applications of zirconium(IV)-catalyzed ester -amide exchange.)
Stephen L. Buchwald post-doc 2008-2010 MIT
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Publications

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Zell D, Kingston C, Jermaks J, et al. (2021) Stereoconvergent and -divergent Synthesis of Tetrasubstituted Alkenes by Nickel-Catalyzed Cross-Couplings. Journal of the American Chemical Society. 143: 19078-19090
Bigler R, Mack KA, Shen J, et al. (2019) Asymmetric Hydrogenation of Unfunctionalized, Tetrasubstituted, Acyclic Olefins. Angewandte Chemie (International Ed. in English)
Wong N, Petronijević F, Hong AY, et al. (2019) Stereocontrolled Synthesis of Arylomycin-Based Gram-Negative Antibiotic GDC-5338. Organic Letters
Han C, Alabanza LM, Kelly SM, et al. (2019) BBDFA: A Practical Reagent for Trifluoromethylation of Allylic and Benzylic Alcohols on Preparative Scale Organic Process Research & Development. 23: 1695-1702
Han C, Kelly SM, Cravillion T, et al. (2019) Synthesis of PI3K inhibitor GDC-0077 via a stereocontrolled N-arylation of α-amino acids Tetrahedron. 75: 4351-4357
Savage S, McClory A, Zhang H, et al. (2018) Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin. The Journal of Organic Chemistry
Young IS, Glass AL, Cravillion T, et al. (2018) Palladium-Catalyzed Site-Selective Amidation of Dichloroazines. Organic Letters
Dalziel ME, Deichert JA, Carrera DE, et al. (2018) Magnesium Ethoxide Promoted Conversion of Nitriles to Amidines and Its Application in 5,6-Dihydroimidazobenzoxazepine Synthesis. Organic Letters
Lim NK, Cravillion T, Savage S, et al. (2018) Synthesis of a Selective Estrogen Receptor Degrader via a Stereospecific Elimination Approach. Organic Letters
Zhang H, Cravillion T, Lim N, et al. (2018) Development of an Efficient Manufacturing Process for Reversible Bruton’s Tyrosine Kinase Inhibitor GDC-0853 Organic Process Research & Development. 22: 978-990
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