Daniel P. Dowling, Ph.D.

Affiliations: 
University of Massachusetts, Boston, Boston, MA 
Area:
structure-mechanism of hydrolytic metalloenzymes
Website:
http://www.dpdowlinglab.net/index.html/
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"Daniel Dowling"
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SNBCP

Parents

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David W. Christianson grad student 2009 Penn
 (Structural studies of two related metallohydrolases: human histone deacetylase 8 and malarial arginase.)
Catherine L. Drennan post-doc MIT

Children

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Andrew D. Gnann grad student U Mass Boston (Crystallography Tree)
Reyaz Gonzalez grad student 2018- University of Massachusetts - Boston
Jeremy J.M. Liew grad student 2018- U Mass Boston
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Publications

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Grell TAJ, Bell BN, Nguyen C, et al. (2018) Crystal structure of AdoMet radical enzyme 7-carboxy-7-deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe-4S] cluster engender flavodoxin specificity. Protein Science : a Publication of the Protein Society
Bruender NA, Grell TA, Dowling DP, et al. (2017) 7-Carboxy-7-deazaguanine synthase - A radical S-adenosyl-L-methionine enzyme with polar tendencies. Journal of the American Chemical Society
Dowling DP, Kung Y, Croft AK, et al. (2016) Structural elements of an NRPS cyclization domain and its intermodule docking domain. Proceedings of the National Academy of Sciences of the United States of America
Dowling DP, Miles ZD, Köhrer C, et al. (2016) Molecular basis of cobalamin-dependent RNA modification. Nucleic Acids Research
Dowling DP, Bruender NA, Young AP, et al. (2014) Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism. Nature Chemical Biology. 10: 106-12
Dowling DP, Vey JL, Croft AK, et al. (2012) Structural diversity in the AdoMet radical enzyme superfamily. Biochimica Et Biophysica Acta. 1824: 1178-95
Dowling DP, Croft AK, Drennan CL. (2012) Radical use of Rossmann and TIM barrel architectures for controlling coenzyme B12 chemistry. Annual Review of Biophysics. 41: 403-27
Ilies M, Dowling DP, Lombardi PM, et al. (2011) Synthesis of a new trifluoromethylketone analogue of l-arginine and contrasting inhibitory activity against human arginase I and histone deacetylase 8. Bioorganic & Medicinal Chemistry Letters. 21: 5854-8
Lombardi PM, Cole KE, Dowling DP, et al. (2011) Structure, mechanism, and inhibition of histone deacetylases and related metalloenzymes. Current Opinion in Structural Biology. 21: 735-43
Cole KE, Dowling DP, Boone MA, et al. (2011) Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases. Journal of the American Chemical Society. 133: 12474-7
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