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David W. Christianson

Chemistry University of Pennsylvania, Philadelphia, PA, United States 
structure-mechanism of hydrolytic metalloenzymes
"David Christianson"
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William N. Lipscomb grad student 1987 Harvard
 (Structure-function studies of carboxypeptidase A)


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Satish K. Nair grad student 1994 Penn
Jonathan M. Caruthers grad student 2000 Penn
John D. Cox grad student 2000 Penn
Chiana M. Paschall grad student 2000 Penn
Chu-Young Kim grad student 2001 Penn
Evis P. Cama grad student 2003 Penn
German A. Gomez grad student 2006 Penn
Kevin Jude grad student 2007 Penn
Ekaterina Shishova grad student 2007 Penn
L. S. Vedula grad student 2007 Penn
Heather A. Gennadios grad student 2008 Penn
Daniel P. Dowling grad student 2009 Penn
Julie A. Aaron grad student 2010 Penn
Patrick M. Lombardi grad student 2006-2011 Penn
Yang Hai grad student 2011-2016 Penn
Trey A Ronnebaum post-doc 2018- Penn
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Osko JD, Porter NJ, Decroos C, et al. (2020) Structural Analysis of Histone Deacetylase 8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders. Journal of Structural Biology. 107681
Ronnebaum TA, Gardner SM, Christianson DW. (2020) An Aromatic Cluster in the Active Site of -Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways. Biochemistry
Blank PN, Barnett AA, Ronnebaum TA, et al. (2020) Structural studies of geranylgeranylglyceryl phosphate synthase, a prenyltransferase found in thermophilic Euryarchaeota. Acta Crystallographica Section D-Biological Crystallography. 76: 542-557
Ronnebaum TA, Gupta K, Christianson DW. (2020) Higher-Order Oligomerization of a Chimeric αβγ Bifunctional Diterpene Synthase with Prenyltransferase and Class II Cyclase Activities is Concentration-Dependent. Journal of Structural Biology. 107463
Welker Leng K, Castaneda CA, Decroos C, et al. (2019) Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of Phosphomimetic S39E Mutant. Biochemistry
Blank PN, Barrow GH, Christianson DW. (2019) Crystal structure of F95Q epi-isozizaene synthase, an engineered sesquiterpene cyclase that generates biofuel precursors β- and γ-curcumene. Journal of Structural Biology
Blank PN, Shinsky SA, Christianson DW. (2019) Structure of Sesquisabinene Synthase 1, a Terpenoid Cyclase That Generates a Strained [3.1.0] Bridged-Bicyclic Product. Acs Chemical Biology
Blank PN, Pemberton TA, Chow JY, et al. (2018) Crystal Structure of Cucumene Synthase, a Terpenoid Cyclase That Generates a Linear Triquinane Sesquiterpene. Biochemistry
Blank PN, Harris GG, Chou WKW, et al. (2017) Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes. Biochemistry
Pemberton TA, Chen M, Harris GG, et al. (2017) Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases. Biochemistry
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