David W. Christianson
Affiliations: | Chemistry | University of Pennsylvania, Philadelphia, PA, United States |
Area:
structure-mechanism of hydrolytic metalloenzymesWebsite:
http://webdev.chem.upenn.edu/chem/research/faculty.php?id=15Google:
"David Christianson"Mean distance: 7.43 | S | N | B | C | P |
Parents
Sign in to add mentor| William N. Lipscomb | grad student | 1987 | Harvard | |
| (Structure-function studies of carboxypeptidase A) | ||||
Children
Sign in to add trainee| Satish K. Nair | grad student | 1994 | Penn |
| Jonathan M. Caruthers | grad student | 2000 | Penn |
| John D. Cox | grad student | 2000 | Penn |
| Chiana M. Paschall | grad student | 2000 | Penn |
| Chu-Young Kim | grad student | 2001 | Penn |
| Evis P. Cama | grad student | 2003 | Penn |
| German A. Gomez | grad student | 2006 | Penn |
| Kevin Jude | grad student | 2007 | Penn |
| Ekaterina Shishova | grad student | 2007 | Penn |
| L. S. Vedula | grad student | 2007 | Penn |
| Heather A. Gennadios | grad student | 2008 | Penn |
| Daniel P. Dowling | grad student | 2009 | Penn |
| Julie A. Aaron | grad student | 2010 | Penn |
| Patrick M. Lombardi | grad student | 2006-2011 | Penn |
| Yang Hai | grad student | 2011-2016 | Penn |
| Trey A Ronnebaum | post-doc | 2018- | Penn |
| Kathryn Cole | post-doc | 2009-2011 | Penn |
BETA: Related publications
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Publications
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| Watson PR, Gupta S, Hosseinzadeh P, et al. (2023) Macrocyclic Octapeptide Binding and Inferences on Protein Substrate Binding to Histone Deacetylase 6. Acs Chemical Biology |
| Eaton SA, Ronnebaum TA, Roose BW, et al. (2022) Structural Basis of Substrate Promiscuity and Catalysis by the Reverse Prenyltransferase -Dimethylallyl-l-tryptophan Synthase from . Biochemistry. 61: 2025-2035 |
| Tararina MA, Yee DA, Tang Y, et al. (2022) Structure of the Repurposed Fungal Terpene Cyclase FlvF Implicated in the C-N Bond-Forming Reaction of Flavunoidine Biosynthesis. Biochemistry. 61: 2014-2024 |
| Ronnebaum TA, Eaton SA, Brackhahn EAE, et al. (2021) Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase. Biochemistry. 60: 3162-3172 |
| Faylo JL, Ronnebaum TA, Christianson DW. (2021) Assembly-Line Catalysis in Bifunctional Terpene Synthases. Accounts of Chemical Research |
| Olaoye OO, Watson PR, Nawar N, et al. (2021) Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype. Journal of Medicinal Chemistry |
| Herbst-Gervasoni CJ, Christianson DW. (2021) X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10. Biochemistry |
| Ronnebaum TA, Gardner SM, Christianson DW. (2020) An Aromatic Cluster in the Active Site of -Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways. Biochemistry |
| Osko JD, Christianson DW. (2020) Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6. Acta Crystallographica. Section F, Structural Biology Communications. 76: 428-437 |
| Reßing N, S Ouml Nnichsen M, Osko J, et al. (2020) Multicomponent synthesis, binding mode and structure-activity relationships of selective histone deacetylase 6 (HDAC6) inhibitors with bifurcated capping groups. Journal of Medicinal Chemistry |