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David W. Christianson

Chemistry University of Pennsylvania, Philadelphia, PA, United States 
structure-mechanism of hydrolytic metalloenzymes
"David Christianson"
Mean distance: 7.43


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William N. Lipscomb grad student 1987 Harvard
 (Structure-function studies of carboxypeptidase A)


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Satish K. Nair grad student 1994 Penn
Jonathan M. Caruthers grad student 2000 Penn
John D. Cox grad student 2000 Penn
Chiana M. Paschall grad student 2000 Penn
Chu-Young Kim grad student 2001 Penn
Evis P. Cama grad student 2003 Penn
German A. Gomez grad student 2006 Penn
Kevin Jude grad student 2007 Penn
Ekaterina Shishova grad student 2007 Penn
L. S. Vedula grad student 2007 Penn
Heather A. Gennadios grad student 2008 Penn
Daniel P. Dowling grad student 2009 Penn
Julie A. Aaron grad student 2010 Penn
Patrick M. Lombardi grad student 2006-2011 Penn
Yang Hai grad student 2011-2016 Penn
Trey A Ronnebaum post-doc 2018- Penn
Kathryn Cole post-doc 2009-2011 Penn
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Ronnebaum TA, Eaton SA, Brackhahn EAE, et al. (2021) Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase. Biochemistry. 60: 3162-3172
Faylo JL, Ronnebaum TA, Christianson DW. (2021) Assembly-Line Catalysis in Bifunctional Terpene Synthases. Accounts of Chemical Research
Olaoye OO, Watson PR, Nawar N, et al. (2021) Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype. Journal of Medicinal Chemistry
Herbst-Gervasoni CJ, Christianson DW. (2021) X-ray Crystallographic Snapshots of Substrate Binding in the Active Site of Histone Deacetylase 10. Biochemistry
Ronnebaum TA, Gardner SM, Christianson DW. (2020) An Aromatic Cluster in the Active Site of -Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways. Biochemistry
Osko JD, Christianson DW. (2020) Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6. Acta Crystallographica. Section F, Structural Biology Communications. 76: 428-437
Reßing N, S Ouml Nnichsen M, Osko J, et al. (2020) Multicomponent synthesis, binding mode and structure-activity relationships of selective histone deacetylase 6 (HDAC6) inhibitors with bifurcated capping groups. Journal of Medicinal Chemistry
He H, Bian G, Herbst-Gervasoni CJ, et al. (2020) Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases. Nature Communications. 11: 3958
Herbst-Gervasoni CJ, Steimbach RR, Morgen M, et al. (2020) Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase. Acs Chemical Biology
Blank PN, Barnett AA, Ronnebaum TA, et al. (2020) Structural studies of geranylgeranylglyceryl phosphate synthase, a prenyltransferase found in thermophilic Euryarchaeota. Acta Crystallographica Section D-Biological Crystallography. 76: 542-557
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