Angela S. Fleischhacker, Ph.D.

Affiliations: 
2007 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Mechanisms of B12- and folate dependent enzymes
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"Angela Fleischhacker"
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Rowena Green Matthews grad student 2007 University of Michigan
 (Governing conformation in cobalamin -dependent methionine synthase: Probing the roles of the axial cobalt ligands.)
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Publications

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Fleischhacker AS, Gunawan AL, Kochert BA, et al. (2020) The heme regulatory motifs of heme oxygenase-2 contribute to the transfer of heme to the catalytic site for degradation. The Journal of Biological Chemistry
Davydov R, Fleischhacker AS, Bagai I, et al. (2015) Comparison of the Mechanisms of Heme Hydroxylation by Heme Oxygenases-1 and -2: Kinetic and Cryoreduction Studies. Biochemistry
Fleischhacker AS, Sharma A, Choi M, et al. (2015) The C-terminal heme regulatory motifs of heme oxygenase-2 are redox-regulated heme binding sites. Biochemistry. 54: 2709-18
Bagai I, Sarangi R, Fleischhacker AS, et al. (2015) Spectroscopic studies reveal that the heme regulatory motifs of heme oxygenase-2 are dynamically disordered and exhibit redox-dependent interaction with heme. Biochemistry. 54: 2693-708
Giel JL, Nesbit AD, Mettert EL, et al. (2013) Regulation of iron-sulphur cluster homeostasis through transcriptional control of the Isc pathway by [2Fe-2S]-IscR in Escherichia coli. Molecular Microbiology. 87: 478-92
Fleischhacker AS, Stubna A, Hsueh KL, et al. (2012) Characterization of the [2Fe-2S] cluster of Escherichia coli transcription factor IscR. Biochemistry. 51: 4453-62
Fleischhacker AS, Kiley PJ. (2011) Iron-containing transcription factors and their roles as sensors. Current Opinion in Chemical Biology. 15: 335-41
Liptak MD, Fleischhacker AS, Matthews RG, et al. (2009) Spectroscopic and computational characterization of the base-off forms of cob(II)alamin. The Journal of Physical Chemistry. B. 113: 5245-54
Fleischhacker AS, Matthews RG. (2007) Ligand trans influence governs conformation in cobalamin-dependent methionine synthase. Biochemistry. 46: 12382-92
Liptak MD, Fleischhacker AS, Matthews RG, et al. (2007) Probing the role of the histidine 759 ligand in cobalamin-dependent methionine synthase. Biochemistry. 46: 8024-35
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